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Conserved domains on  [gi|490521768|ref|WP_004387209|]
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MULTISPECIES: D-alanyl-D-alanine carboxypeptidase DacA [Cronobacter]

Protein Classification

D-alanyl-D-alanine carboxypeptidase DacA( domain architecture ID 11484951)

D-alanyl-D-alanine carboxypeptidase DacA removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10793 PRK10793
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional
 1-404 0e+00

D-alanyl-D-alanine carboxypeptidase fraction A; Provisional


:

Pssm-ID: 182736 [Multi-domain]  Cd Length: 403  Bit Score: 839.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768   1 MKTTFSVRFMQRLAVTTALSVAAlSTAAHADDLNIKTMIPGVPQIDAEAYILIDYNSGKVLAEQNADARRDPASLTKMMT 80
Cdd:PRK10793   1 MKTIFSARIMKRLALTTALCTAF-ISAAHADDLNIKTMIPGVPQIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  81 SYVIGQAMKAGKFKESDLVTIGNDAWATGNPVFKGSSLMFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFV 160
Cdd:PRK10793  80 SYVIGQAMKAGKFKETDLVTVGNDAWATGNPVFKGSSLMFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 161 GLMNSYVTALGLKNTHFQTVHGLDADGQYSSARDMALIGQALIRDVPNEYSIYKEKEFTFNGIRQTNRNGLLWDNSLNVD 240
Cdd:PRK10793 160 GLMNSYVNALGLKNTHFQTVHGLDADGQYSSARDMALIGQALIRDVPNEYAIYKEKEFTFNGIRQLNRNGLLWDNSLNVD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 241 GIKTGHTDKAGYNLVASATEGQMRLISAVMGGRTFKGREAESKKLLTWGFRFFETVNPLKAGKEFASEPAWFGDNDRASL 320
Cdd:PRK10793 240 GIKTGHTDKAGYNLVASATEGQMRLISAVMGGRTFKGRETESKKLLTWGFRFFETVNPLKVGKEFASEPVWFGDSDRASL 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 321 GVDKDIYLTIPRGRMKDLKASYVLNTSELHAPLAKNQVVGTINFQLDGKTIEQRPLVVLEEIQEGNFFGRIIDYIKLMFH 400
Cdd:PRK10793 320 GVDKDVYLTIPRGRMKDLKASYVLNTSELHAPLQKNQVVGTINFQLDGKTIEQRPLVVLQEIPEGNFFGKIIDYIKLMFH 399


                 ....
gi 490521768 401 HWFG 404
Cdd:PRK10793 400 HWFG 403
 
Name Accession Description Interval E-value
PRK10793 PRK10793
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional
 1-404 0e+00

D-alanyl-D-alanine carboxypeptidase fraction A; Provisional


Pssm-ID: 182736 [Multi-domain]  Cd Length: 403  Bit Score: 839.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768   1 MKTTFSVRFMQRLAVTTALSVAAlSTAAHADDLNIKTMIPGVPQIDAEAYILIDYNSGKVLAEQNADARRDPASLTKMMT 80
Cdd:PRK10793   1 MKTIFSARIMKRLALTTALCTAF-ISAAHADDLNIKTMIPGVPQIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  81 SYVIGQAMKAGKFKESDLVTIGNDAWATGNPVFKGSSLMFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFV 160
Cdd:PRK10793  80 SYVIGQAMKAGKFKETDLVTVGNDAWATGNPVFKGSSLMFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 161 GLMNSYVTALGLKNTHFQTVHGLDADGQYSSARDMALIGQALIRDVPNEYSIYKEKEFTFNGIRQTNRNGLLWDNSLNVD 240
Cdd:PRK10793 160 GLMNSYVNALGLKNTHFQTVHGLDADGQYSSARDMALIGQALIRDVPNEYAIYKEKEFTFNGIRQLNRNGLLWDNSLNVD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 241 GIKTGHTDKAGYNLVASATEGQMRLISAVMGGRTFKGREAESKKLLTWGFRFFETVNPLKAGKEFASEPAWFGDNDRASL 320
Cdd:PRK10793 240 GIKTGHTDKAGYNLVASATEGQMRLISAVMGGRTFKGRETESKKLLTWGFRFFETVNPLKVGKEFASEPVWFGDSDRASL 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 321 GVDKDIYLTIPRGRMKDLKASYVLNTSELHAPLAKNQVVGTINFQLDGKTIEQRPLVVLEEIQEGNFFGRIIDYIKLMFH 400
Cdd:PRK10793 320 GVDKDVYLTIPRGRMKDLKASYVLNTSELHAPLQKNQVVGTINFQLDGKTIEQRPLVVLQEIPEGNFFGKIIDYIKLMFH 399


                 ....
gi 490521768 401 HWFG 404
Cdd:PRK10793 400 HWFG 403
DacC COG1686
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
10-390 3.50e-137

D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441292 [Multi-domain]  Cd Length: 324  Bit Score: 394.97  E-value: 3.50e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  10 MQRLAVTTALSVAALSTAAHADDlniktmipgvPQIDAEAYILIDYNSGKVLAEQNADARRDPASLTKMMTSYVIGQAMK 89
Cdd:COG1686    1 MKKLLLLALLLLLAAAAAAPAAP----------PDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALK 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  90 AGKFKESDLVTIGNDAWATGnpvfkgSSLMFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVGLMNSYVTA 169
Cdd:COG1686   71 AGKISLDDKVTVSEEAARTG------GSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKE 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 170 LGLKNTHFQTVHGLDADGQYSSARDMALIGQALIRDVPNEYSIYKEKEFTFN---GIRQTNRNGLLWDNSlNVDGIKTGH 246
Cdd:COG1686  145 LGMTNTHFVNPTGLPDPGHYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPngrGITLRNTNRLLGRYP-GVDGLKTGY 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 247 TDKAGYNLVASATEGQMRLISAVMGGRTFKGREAESKKLLTWGFrffetvnplkagkefasepawfgdndraslgvdkdi 326
Cdd:COG1686  224 TDAAGYCLVASAKRGGRRLIAVVLGAPSEKARFADAAKLLDYGF------------------------------------ 267

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490521768 327 yltiPRGRmkDLKASYVLNtSELHAPLAKNQVVGTINFQLDGKTIEQRPLVVLEEIQEGNFFGR 390
Cdd:COG1686  268 ----PKGE--ALKAEVVLD-GPLKAPVKKGQVVGTLVVTLDGKTIAEVPLVAAEDVEKAGFFSR 324
Peptidase_S11 pfam00768
D-alanyl-D-alanine carboxypeptidase;
40-273 1.22e-128

D-alanyl-D-alanine carboxypeptidase;


Pssm-ID: 425859 [Multi-domain]  Cd Length: 234  Bit Score: 369.79  E-value: 1.22e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768   40 PGVPQIDAEAYILIDYNSGKVLAEQNADARRDPASLTKMMTSYVIGQAMKAGKFKESDLVTIGNDAWATGNPvfkGSSLM 119
Cdd:pfam00768   1 VSAPEIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNP---GSSNI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  120 FLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVGLMNSYVTALGLKNTHFQTVHGLDADGQYSSARDMALIG 199
Cdd:pfam00768  78 FLKPGSQVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDAHGQYSSARDMAILA 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490521768  200 QALIRDVPNEYSIYKEKEFTF---NGIRQTNRNGLLWDNSLNVDGIKTGHTDKAGYNLVASATEGQMRLISAVMGGR 273
Cdd:pfam00768 158 KALIKDLPEELSITKEKSFTFrgiNKINQRNRNGLLWDKTWNVDGLKTGYTNEAGYCLVASATKGGMRLISVVMGAF 234
PBP4_Staph NF038258
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ...
 44-281 2.59e-31

penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.


Pssm-ID: 468436 [Multi-domain]  Cd Length: 365  Bit Score: 122.39  E-value: 2.59e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  44 QIDAEAYILIDYNsGKVLAEQNADARRDPASLTKMMTSYVIGQAMKAGKFKESDLVTIGNDAwatgnpvFKGSSL----- 118
Cdd:NF038258  37 QYNPEGAIVTTQT-GQILYDYHGNKKWDPASMTKLMTMYLTLEAIKKGKLSLNDKVKITSDY-------EKMSTLpnlst 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 119 MFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVGLMNSYVTALGLKNTHFQTVHGLDAD--GQY------- 189
Cdd:NF038258 109 FPLKPGQTYTIKELLKQTALASSNAAALILAEKVSGNTSKFTDRMNEKAKALGMKHTHFTNPSGADNNllKPYapkkykd 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 190 -----SSARDMALIGQALIRDVPNEYSIYKEKEFTFNGIRQTNRNGLLWDNSL---NVDGIKTGHTDKaGYNLVASATEG 261
Cdd:NF038258 189 etkskSTAKDMAILSQHLIKKHPKILKYTKLTADTQHGVTLYTTNLSLPGQPMslkGTDGLKTGTSDE-GYNLALTTKRD 267

                        250       260
                 ....*....|....*....|
gi 490521768 262 QMRLISAVMGGRTFKGREAE 281
Cdd:NF038258 268 GLRINQVIMNVGPYPSEGAK 287
PBP5_C smart00936
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 293-384 1.15e-30

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 198004 [Multi-domain]  Cd Length: 92  Bit Score: 112.69  E-value: 1.15e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768   293 FETVNPLKAGKEFASEPAWFGDNDRASLGVDKDIYLTIPRGRMKDLKASYVLNTSELHAPLAKNQVVGTINFQLDGKTIE 372
Cdd:smart00936   1 FETVKLYKKGQVVGTVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKPELEAPIKKGQVVGTLVVTLDGKLIG 80

                           90
                   ....*....|..
gi 490521768   373 QRPLVVLEEIQE 384
Cdd:smart00936  81 EVPLVALEDVEK 92
 
Name Accession Description Interval E-value
PRK10793 PRK10793
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional
 1-404 0e+00

D-alanyl-D-alanine carboxypeptidase fraction A; Provisional


Pssm-ID: 182736 [Multi-domain]  Cd Length: 403  Bit Score: 839.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768   1 MKTTFSVRFMQRLAVTTALSVAAlSTAAHADDLNIKTMIPGVPQIDAEAYILIDYNSGKVLAEQNADARRDPASLTKMMT 80
Cdd:PRK10793   1 MKTIFSARIMKRLALTTALCTAF-ISAAHADDLNIKTMIPGVPQIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  81 SYVIGQAMKAGKFKESDLVTIGNDAWATGNPVFKGSSLMFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFV 160
Cdd:PRK10793  80 SYVIGQAMKAGKFKETDLVTVGNDAWATGNPVFKGSSLMFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 161 GLMNSYVTALGLKNTHFQTVHGLDADGQYSSARDMALIGQALIRDVPNEYSIYKEKEFTFNGIRQTNRNGLLWDNSLNVD 240
Cdd:PRK10793 160 GLMNSYVNALGLKNTHFQTVHGLDADGQYSSARDMALIGQALIRDVPNEYAIYKEKEFTFNGIRQLNRNGLLWDNSLNVD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 241 GIKTGHTDKAGYNLVASATEGQMRLISAVMGGRTFKGREAESKKLLTWGFRFFETVNPLKAGKEFASEPAWFGDNDRASL 320
Cdd:PRK10793 240 GIKTGHTDKAGYNLVASATEGQMRLISAVMGGRTFKGRETESKKLLTWGFRFFETVNPLKVGKEFASEPVWFGDSDRASL 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 321 GVDKDIYLTIPRGRMKDLKASYVLNTSELHAPLAKNQVVGTINFQLDGKTIEQRPLVVLEEIQEGNFFGRIIDYIKLMFH 400
Cdd:PRK10793 320 GVDKDVYLTIPRGRMKDLKASYVLNTSELHAPLQKNQVVGTINFQLDGKTIEQRPLVVLQEIPEGNFFGKIIDYIKLMFH 399


                 ....
gi 490521768 401 HWFG 404
Cdd:PRK10793 400 HWFG 403
PRK10001 PRK10001
serine-type D-Ala-D-Ala carboxypeptidase;
10-404 0e+00

serine-type D-Ala-D-Ala carboxypeptidase;


Pssm-ID: 182189 [Multi-domain]  Cd Length: 400  Bit Score: 563.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  10 MQRLAVTTALSVAALSTAAHADDlniktmIPGVPQIDAEAYILIDYNSGKVLAEQNADARRDPASLTKMMTSYVIGQAMK 89
Cdd:PRK10001   8 LRGLAAGSAFLFLFAPTAFAAEQ------TVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  90 AGKFKESDLVTIGNDAWATGNPVFKGSSLMFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVGLMNSYVTA 169
Cdd:PRK10001  82 ADKIKLTDMVTVGKDAWATGNPALRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 170 LGLKNTHFQTVHGLDADGQYSSARDMALIGQALIRDVPNEYSIYKEKEFTFNGIRQTNRNGLLWDNSLNVDGIKTGHTDK 249
Cdd:PRK10001 162 LGLTNTTFQTVHGLDAPGQFSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTGTTAG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 250 AGYNLVASATEGQMRLISAVMGGRTFKGREAESKKLLTWGFRFFETVNPLKAGKEFASEPAWFGDNDRASLGVDKDIYLT 329
Cdd:PRK10001 242 AGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKPDATFVTQRVWFGDKSEVNLGAGEAGSVT 321

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490521768 330 IPRGRMKDLKASYVLNTSELHAPLAKNQVVGTINFQLDGKTIEQRPLVVLEEIQEGNFFGRIIDYIKLMFHHWFG 404
Cdd:PRK10001 322 IPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQLNGKSIEQRPLIVMENVEEGGFFSRMWDFVMMKFHQWFG 396
dacD PRK11397
serine-type D-Ala-D-Ala carboxypeptidase DacD;
12-399 1.51e-176

serine-type D-Ala-D-Ala carboxypeptidase DacD;


Pssm-ID: 183117 [Multi-domain]  Cd Length: 388  Bit Score: 497.42  E-value: 1.51e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  12 RLAVTTALSVAALSTAAHADDLNIKtmiPGVPQIDAEAYILIDYNSGKVLAEQNADARRDPASLTKMMTSYVIGQAMKAG 91
Cdd:PRK11397   4 RLIIAASLFAFNLSSAFAAENIPFS---PQPPAIDAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  92 KFKESDLVTIGNDAWATGNPVFKGSSLMFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVGLMNSYVTALG 171
Cdd:PRK11397  81 RITPDDIVTVGRDAWAKDNPVFVGSSLMFLKEGDRVSVRDLSRGLIVDSGNDACVALADYIAGGQRQFVEMMNNYVEKLH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 172 LKNTHFQTVHGLDADGQYSSARDMALIGQALIRDVPNEYSIYKEKEFTFNGIRQTNRNGLLWDNSLNVDGIKTGHTDKAG 251
Cdd:PRK11397 161 LKDTHFETVHGLDAPGQHSSAYDLAVLSRAIIHGEPEFYHMYSEKSLTWNGITQQNRNGLLWDKTMNVDGLKTGHTSGAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 252 YNLVASATEGQMRLISAVMGGRTFKGREAESKKLLTWGFRFFETVNPLKAGKEFASEPAWFGDNDRASLGVDKDIYLTIP 331
Cdd:PRK11397 241 FNLIASAVDGQRRLIAVVMGADSAKGREEQARKLLRWGQQNFTTVQILHRGKKVGTERIWYGDKENIALGTEQDFWMVLP 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490521768 332 RGRMKDLKASYVLNTSELHAPLAKNQVVGTINFQLDGKTIEQRPLVVLEEIQEGNFFGRIIDYIKLMF 399
Cdd:PRK11397 321 KAEIPHIKAKYVLDGKELEAPISAHQRVGEIELYDRDKQVAHWPLVTLESVGEGGMFSRLSDYFHHKA 388
DacC COG1686
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
10-390 3.50e-137

D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441292 [Multi-domain]  Cd Length: 324  Bit Score: 394.97  E-value: 3.50e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  10 MQRLAVTTALSVAALSTAAHADDlniktmipgvPQIDAEAYILIDYNSGKVLAEQNADARRDPASLTKMMTSYVIGQAMK 89
Cdd:COG1686    1 MKKLLLLALLLLLAAAAAAPAAP----------PDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALK 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  90 AGKFKESDLVTIGNDAWATGnpvfkgSSLMFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVGLMNSYVTA 169
Cdd:COG1686   71 AGKISLDDKVTVSEEAARTG------GSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKE 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 170 LGLKNTHFQTVHGLDADGQYSSARDMALIGQALIRDVPNEYSIYKEKEFTFN---GIRQTNRNGLLWDNSlNVDGIKTGH 246
Cdd:COG1686  145 LGMTNTHFVNPTGLPDPGHYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPngrGITLRNTNRLLGRYP-GVDGLKTGY 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 247 TDKAGYNLVASATEGQMRLISAVMGGRTFKGREAESKKLLTWGFrffetvnplkagkefasepawfgdndraslgvdkdi 326
Cdd:COG1686  224 TDAAGYCLVASAKRGGRRLIAVVLGAPSEKARFADAAKLLDYGF------------------------------------ 267

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490521768 327 yltiPRGRmkDLKASYVLNtSELHAPLAKNQVVGTINFQLDGKTIEQRPLVVLEEIQEGNFFGR 390
Cdd:COG1686  268 ----PKGE--ALKAEVVLD-GPLKAPVKKGQVVGTLVVTLDGKTIAEVPLVAAEDVEKAGFFSR 324
Peptidase_S11 pfam00768
D-alanyl-D-alanine carboxypeptidase;
40-273 1.22e-128

D-alanyl-D-alanine carboxypeptidase;


Pssm-ID: 425859 [Multi-domain]  Cd Length: 234  Bit Score: 369.79  E-value: 1.22e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768   40 PGVPQIDAEAYILIDYNSGKVLAEQNADARRDPASLTKMMTSYVIGQAMKAGKFKESDLVTIGNDAWATGNPvfkGSSLM 119
Cdd:pfam00768   1 VSAPEIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNP---GSSNI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  120 FLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVGLMNSYVTALGLKNTHFQTVHGLDADGQYSSARDMALIG 199
Cdd:pfam00768  78 FLKPGSQVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDAHGQYSSARDMAILA 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490521768  200 QALIRDVPNEYSIYKEKEFTF---NGIRQTNRNGLLWDNSLNVDGIKTGHTDKAGYNLVASATEGQMRLISAVMGGR 273
Cdd:pfam00768 158 KALIKDLPEELSITKEKSFTFrgiNKINQRNRNGLLWDKTWNVDGLKTGYTNEAGYCLVASATKGGMRLISVVMGAF 234
PBP4_Staph NF038258
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ...
 44-281 2.59e-31

penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.


Pssm-ID: 468436 [Multi-domain]  Cd Length: 365  Bit Score: 122.39  E-value: 2.59e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  44 QIDAEAYILIDYNsGKVLAEQNADARRDPASLTKMMTSYVIGQAMKAGKFKESDLVTIGNDAwatgnpvFKGSSL----- 118
Cdd:NF038258  37 QYNPEGAIVTTQT-GQILYDYHGNKKWDPASMTKLMTMYLTLEAIKKGKLSLNDKVKITSDY-------EKMSTLpnlst 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 119 MFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVGLMNSYVTALGLKNTHFQTVHGLDAD--GQY------- 189
Cdd:NF038258 109 FPLKPGQTYTIKELLKQTALASSNAAALILAEKVSGNTSKFTDRMNEKAKALGMKHTHFTNPSGADNNllKPYapkkykd 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 190 -----SSARDMALIGQALIRDVPNEYSIYKEKEFTFNGIRQTNRNGLLWDNSL---NVDGIKTGHTDKaGYNLVASATEG 261
Cdd:NF038258 189 etkskSTAKDMAILSQHLIKKHPKILKYTKLTADTQHGVTLYTTNLSLPGQPMslkGTDGLKTGTSDE-GYNLALTTKRD 267

                        250       260
                 ....*....|....*....|
gi 490521768 262 QMRLISAVMGGRTFKGREAE 281
Cdd:NF038258 268 GLRINQVIMNVGPYPSEGAK 287
PBP5_C smart00936
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 293-384 1.15e-30

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 198004 [Multi-domain]  Cd Length: 92  Bit Score: 112.69  E-value: 1.15e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768   293 FETVNPLKAGKEFASEPAWFGDNDRASLGVDKDIYLTIPRGRMKDLKASYVLNTSELHAPLAKNQVVGTINFQLDGKTIE 372
Cdd:smart00936   1 FETVKLYKKGQVVGTVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKPELEAPIKKGQVVGTLVVTLDGKLIG 80

                           90
                   ....*....|..
gi 490521768   373 QRPLVVLEEIQE 384
Cdd:smart00936  81 EVPLVALEDVEK 92
PBP5_C pfam07943
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 293-384 1.85e-29

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 429749 [Multi-domain]  Cd Length: 91  Bit Score: 109.61  E-value: 1.85e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  293 FETVNPLKAGKEFASEPAWFGDNDRASLGVDKDIYLTIPRGRMKDLKASYVLNtSELHAPLAKNQVVGTINFQLDGKTIE 372
Cdd:pfam07943   1 FETKKLYKKGDVVKKVKVWKGKKKTVPLGAKEDVYVTVPKGEKKKLKAKVTLK-KPLEAPIKKGQVVGKLEVYLDGKLIG 79

                          90
                  ....*....|..
gi 490521768  373 QRPLVVLEEIQE 384
Cdd:pfam07943  80 EVPLVAKEDVEE 91
pbpG PRK11669
D-alanyl-D-alanine endopeptidase; Provisional
 1-273 3.74e-18

D-alanyl-D-alanine endopeptidase; Provisional


Pssm-ID: 236952  Cd Length: 306  Bit Score: 84.35  E-value: 3.74e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768   1 MKTTFSVrfmqrLAVTTALSVAALSTAAHADDlNIKTMIPGVPQIDAEAYILIDYNSGKVLAEQNADARRDPASLTKMMT 80
Cdd:PRK11669   1 MKFRVSL-----LSLLLLLAGVPFAPQAVAKT-AAATTASQPQEIASGSAMVVDLNTNKVIYSSNPDLVVPIASITKLMT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  81 SYVIGQAMKAgkFKESDLVTIGNdawatgNPVFKGsslMF--LKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDA 158
Cdd:PRK11669  75 AMVVLDAKLP--LDEKLKVDISQ------TPEMKG---VYsrVRLNSEISRKDMLLLALMSSENRAAASLAHHYPGGYKA 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768 159 FVGLMNSYVTALGLKNTHFQTVHGLDADgQYSSARDMALIGQAlIRDVP--NEYSIYKEKEFTFN------GIRQTNRng 230
Cdd:PRK11669 144 FIKAMNAKAKALGMTNTRYVEPTGLSIH-NVSTARDLTKLLIA-SKQYPliGQLSTTREKTATFRkpnytlPFRNTNH-- 219

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 490521768 231 LLWDNSLNVDGIKTGHTDKAGYNLVasategqMRlisAVMGGR 273
Cdd:PRK11669 220 LVYRDNWNIQLTKTGFTNAAGHCLV-------MR---TVINNR 252
PenP COG2367
Beta-lactamase class A [Defense mechanisms];
52-205 1.32e-06

Beta-lactamase class A [Defense mechanisms];


Pssm-ID: 441934 [Multi-domain]  Cd Length: 276  Bit Score: 49.51  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768  52 LIDYNSGKVLAeQNADARRDPASLTKMMTSYVIGQAMKAGKFKESDLVTIGNDAWATGNPVfkgssLMFLKPGMQVPVSQ 131
Cdd:COG2367   39 VLDLDTGETVG-INADERFPAASTFKLPVLAAVLRQVDAGKLSLDERVTLTPEDLVGGSGI-----LQKLPDGTGLTLRE 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490521768 132 LIRGINLQSGNDACVAMADYVAGsqDAFvglmNSYVTALGLKNTHFQ----TVHGLDADGQ-YSSARDMALIGQALIRD 205
Cdd:COG2367  113 LAELMITVSDNTATNLLLRLLGP--DAV----NAFLRSLGLTDTRLDrkepDLNELPGDGRnTTTPRDMARLLAALYRG 185
Beta-lactamase2 pfam13354
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is ...
 62-205 3.17e-06

Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.


Pssm-ID: 463854 [Multi-domain]  Cd Length: 215  Bit Score: 47.65  E-value: 3.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490521768   62 AEQNADARRDPASLTKMMTSYVIGQAMKAGKFKESDLVTIGNDAWATGNPVFKgsslmFLKPGMQVPVSQLIRGINLQSG 141
Cdd:pfam13354  13 LGINGDRSFPAASTIKVPILLAVLEQVDEGKLSLDERLTVTAEDKVGGSGILQ-----YLPDGSQLSLRDLLTLMIAVSD 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490521768  142 NDACVAMADYVagSQDAFvglmNSYVTALGLKNTHFQ----TVHGLDADGQ-YSSARDMALIGQALIRD 205
Cdd:pfam13354  88 NTATNLLIDRL--GLEAV----NARLRALGLRDTRLRrklpDLRAADKGGTnTTTARDMAKLLEALYRG 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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