|
Name |
Accession |
Description |
Interval |
E-value |
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
1-449 |
0e+00 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 937.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 1 MLSIFKPAPHRARLPDGEIDPLYRRLRWQIFMGIFFGYAAYYLVRKNFALAMPYLVEQGFSRGDLGFALSGISIAYGFSK 80
Cdd:PRK11273 1 MLSIFKPAPHKARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQGFSRGDLGFALSGISIAYGFSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 81 FIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSV 160
Cdd:PRK11273 81 FIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 161 WNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFAAILVAIIAFALMRDTPQSCGLPPIEAYKNDYPDDYNEKHEEELT 240
Cdd:PRK11273 161 WNCAHNVGGGLPPLLFLLGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPDDYNEKHEQELT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 241 AKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVFRGN 320
Cdd:PRK11273 241 AKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 321 RGATGVFFMTLVTIATIVYWLNPPGNPNIDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA 400
Cdd:PRK11273 321 RGATGVFFMTLVTIATIVYWLNPAGNPTVDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 490522035 401 SAIVGYTVDFFGWDGGFMVMIGGSILAVLLLIIVMVGEHKHHHATLAKR 449
Cdd:PRK11273 401 SAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKRHHEELLQKR 449
|
|
| glpT |
TIGR00712 |
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted ... |
3-440 |
0e+00 |
|
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted to span the membrane at least 8 times. The two members confirmed experimentally as glycerol-3-phosphate transporters, from E. coli and B. subtilis, share more than 50 % amino acid identity. Proteins of the hexose phosphate and phosphoglycerate transport systems are also quite similar. [Transport and binding proteins, Other]
Pssm-ID: 129795 [Multi-domain] Cd Length: 438 Bit Score: 786.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 3 SIFKPAPHRARLPDGEIDPLYRRLRWQIFMGIFFGYAAYYLVRKNFALAMPYLVEQGFSRGDLGFALSGISIAYGFSKFI 82
Cdd:TIGR00712 1 SIFKPAPHIARLPAAKIDPTYKRLRWQVFLGIFFGYAAYYLVRKNFALAMPYLVEQGFSKGELGFALSAISIAYGFSKFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 83 MGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWN 162
Cdd:TIGR00712 81 MGSVSDRSNPRVFLPAGLILSAAVMLLMGFVPWATSSIAIMFVLLFLNGWFQGMGWPPCGRTMVHWWSQSERGTIVSIWN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 163 CAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFAAILVAIIAFALMRDTPQSCGLPPIEAYKNDYPDDYNEKHEEELTAK 242
Cdd:TIGR00712 161 CAHNIGGGIPPLLVLLGMAWFNDWHAALYFPAICAIIVALFAFAMMRDTPQSCGLPPIEEYRNDYPDDYNEKAEQELTAK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 243 QIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVFRGNRG 322
Cdd:TIGR00712 241 EIFMQYVLPNKLLWYIAIANVFVYLLRYGVLDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFKGNRG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 323 ATGVFFMTLVTIATIVYWLNPPGNPNIDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASA 402
Cdd:TIGR00712 321 ATGVFFMTLVTIAVIVYWMNPAGNPLVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASA 400
|
410 420 430
....*....|....*....|....*....|....*...
gi 490522035 403 IVGYTVDFFGWDGGFMVMIGGSILAVLLLIIVMVGEHK 440
Cdd:TIGR00712 401 IVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKR 438
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
27-435 |
0e+00 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 617.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 27 RWQIFMGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAA 105
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQyGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 106 VMLFMGFVPWATSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFND 185
Cdd:cd17345 81 INILIGFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 186 --WHAALYMPAFAAILVAIIAFALMRDTPQSCGLPPIEAYKNDYPDDYN-EKHEEELTAKQIFMQYVLPNKLLWYIAIAN 262
Cdd:cd17345 161 gwWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADgEEEEQELSAWEIFVKYVLKNKLLWYIAIAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 263 VFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVFRGNRGATGVFFMTLVTIATIVYWLN 342
Cdd:cd17345 241 VFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVALIVYWLA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 343 PpgNPNIDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTVDFFGWDGGFMVMIG 422
Cdd:cd17345 321 P--NVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVDHFGWNGGFIVLLA 398
|
410
....*....|...
gi 490522035 423 GSILAVLLLIIVM 435
Cdd:cd17345 399 SCILAIIFLALVA 411
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
35-417 |
2.14e-179 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 506.14 E-value: 2.14e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 35 FFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFV 113
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEiGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 114 PwatsSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMP 193
Cdd:TIGR00881 81 T----SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 194 AFAAILVAIIAFALMRDTPQSCGLPPIEAYKNDYPDDYNEKHEEELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGIL 273
Cdd:TIGR00881 157 GIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGIL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 274 DWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVFRGNRGATGVFFMTLVTIATIVYWLNPPGNPNIDMAC 353
Cdd:TIGR00881 237 DWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLIC 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490522035 354 MIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSvAASAIVGYTVDFFGWDGGF 417
Cdd:TIGR00881 317 LFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGI-LAGLPLGYLADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
27-435 |
1.28e-126 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 371.22 E-value: 1.28e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 27 RWQIFMGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAA 105
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEiGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 106 VMLFMGFvpwaTSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFnD 185
Cdd:cd17312 81 ANIFMGF----STSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY-G 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 186 WHAALYMPAFAAILVAIIAFALMRDTPqscglppieaykndypddynekheeeltakqifmqyvlpnKLLWYIAIANVFV 265
Cdd:cd17312 156 WRAAFLVPGIVGLVVAIILFFFLRDSP----------------------------------------PYVWVLSLAYAFV 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 266 YLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVFRGNRGATGVFFMTLVTIATIVYWLNpPG 345
Cdd:cd17312 196 YIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFF-PH 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 346 NPNIDMACMIVIGFLIYGPVMLIGLHALE-LAPKKAAGTAAGFTGLFGYLGGSVAASaIVGYTVDFFGWDGGFMVMIGGS 424
Cdd:cd17312 275 NKLLSIVLLFLIGFFVGGPINLIGGAAAQdIGRKEAAGTATGFVGLFGYLGASLAGL-PLGYIIDHYGWSTVFYFLISAA 353
|
410
....*....|.
gi 490522035 425 ILAVLLLIIVM 435
Cdd:cd17312 354 LLSVLLLLSLW 364
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
18-431 |
9.50e-101 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 307.79 E-value: 9.50e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 18 EIDPLYRRLRWQIFMGIFFGYAAYYLVRKNFALAMP-YLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFL 96
Cdd:PRK11663 12 EIDARYRYWRRHILITMYLGYALFYFTRKSFNAAMPeMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFM 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 97 PAGLILAAAVMLFMGFvpwatSSIMVMFVLLF-LCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLL 175
Cdd:PRK11663 92 GIGLIATGIINILFGF-----SSSLWAFALLWvLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 176 flLGMAWFN-DWHAALYMPAFAAILVAIIAFALMRDTPQSCGLPPIEAYKNDYPDDYNEKHEEELTAKQIFMQYVLPNKL 254
Cdd:PRK11663 167 --VGAIALHyGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWRHDALELAQQQEGAGLSRKEILTKYVLLNPY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 255 LWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVFRGNRGATGVFFMTLVTI 334
Cdd:PRK11663 245 IWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAAGILL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 335 ATIVYWLNPPGNPNIDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIvGYTVDFFGWD 414
Cdd:PRK11663 325 SVGSLWLMPFASYVMQAACFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGAALSGYPL-AKVLEIWHWT 403
|
410
....*....|....*...
gi 490522035 415 GGFMVM-IGGSILAVLLL 431
Cdd:PRK11663 404 GFFVVIsIAAGISALLLL 421
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
24-440 |
1.88e-84 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 266.91 E-value: 1.88e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 24 RRLRW-----QIFMGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLP 97
Cdd:PRK09556 19 QRKMWfkpfmQSYLVVFIGYLTMYLIRKNFKAAQNDMISTyGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLP 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 98 AGLILAAAVMLFMGFVPWATSSIMVMFVLLF-LCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLF 176
Cdd:PRK09556 99 FLLILSAICMLGFGASLGSGSVSLGLMIALWaLSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 177 LLGMAWFNDWHAA--LYMPAFAAILVAIIAFALMRDTPQSCGL-PPIEAYKNDYPDDYNEKHEEELTAKQIFMQYVLPNK 253
Cdd:PRK09556 179 LWGANYFFDGHVIgmFIFPSIIALIIGFIGLRYGSDSPEELGWgKAEEIFGEPISEEDKETESTDMTKWQIFVEYVLKNP 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 254 LLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVfRGNRGATGVFFMTLVT 333
Cdd:PRK09556 259 VIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLA-NGRRALVACIALALII 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 334 IATIVYwlNPPGNPNIDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTVD---- 409
Cdd:PRK09556 338 FTLGVY--QHATSEYMYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFAYLFGDSFAKVGLGMIADptkn 415
|
410 420 430
....*....|....*....|....*....|....*....
gi 490522035 410 --------FFGWDGGFMVMIGGSILAVLLLIIVMVGEHK 440
Cdd:PRK09556 416 gtpifgytLTGWAGTFAALDIAAIGCICLMAIVAVMEER 454
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
27-432 |
3.40e-84 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 262.73 E-value: 3.40e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 27 RWQIFMGIFFGYAAYYLVRKNFALAMP-YLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAA 105
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPaMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 106 VMLFMGFvpwaTSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFNd 185
Cdd:cd17488 81 INILFGF----SSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYG- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 186 WHAALYMPAFAAILVAIIAFALMRDTPQscglppieaykndypddynekheeeltakqifmqyvlpnkLLWYIAIANVFV 265
Cdd:cd17488 156 WRAGMYVPGIIAILMGIVLCWRLRDRPP----------------------------------------YIWLLAFCYVLV 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 266 YLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVFRGNRGATGVFFMTLVTIATIVYWLNPPG 345
Cdd:cd17488 196 YVVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKGNRGPMNLIFALGLLVSVGALWLVPVH 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 346 NPNIDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFMVMIGGSI 425
Cdd:cd17488 276 SYWLLATCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAAL-AGYPLAKVIESWGWSGFFIVISIAAA 354
|
....*..
gi 490522035 426 LAVLLLI 432
Cdd:cd17488 355 ISGLLLL 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-435 |
3.93e-70 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 226.29 E-value: 3.93e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 20 DPLYRRLRWQIFMGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPA 98
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADlGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 99 GLILAAAVMLFMGFVPwatsSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLL 178
Cdd:COG2271 81 GLLLWGLATLLFGFAT----SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 179 GMAWFnDWHAALYMPAFAAILVAIIAFalmrdtpqscglppieaykndypddynekheeeltakqifmqyvlpnkllWYI 258
Cdd:COG2271 157 LLAAF-GWRAAFLILGLPGLLLALLRF--------------------------------------------------WLL 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 259 AIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVFRGNRgATGVFFMTLVTIATIV 338
Cdd:COG2271 186 ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRK-LVLAIGLLLAALALLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 339 YWLNPpgNPNIDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFM 418
Cdd:COG2271 265 LALLP--SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGAL-GPLLVGYLLDATGYQAAFL 341
|
410
....*....|....*..
gi 490522035 419 VMIGGSILAVLLLIIVM 435
Cdd:COG2271 342 LLAALALLAALLALLLL 358
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
27-431 |
4.77e-54 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 185.62 E-value: 4.77e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 27 RWQIFMGIFFGYAAYYLVRKNFALAMPYLV-EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAA 105
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMnELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 106 VMLFMGfvpwATSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLgMAWFND 185
Cdd:cd17343 81 TTVAFS----GSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATL-LALSYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 186 WHAALYMPAFAAILVAIIAFALMRDTPQSCGLPPIEAYKNdyPDDYNEKHEEELTAKQifmqyVLPNKLLWYIAIANVFV 265
Cdd:cd17343 156 WRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEES--KGKKKKSPRGESTLKE-----LLLSPFLWLLSLGYLVV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 266 YLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVFR--GNR---------------GATGVFF 328
Cdd:cd17343 229 FGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAkhGSSsrgnprmplalvfmaGLTVSLH 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 329 MTLVTIATivywlnppGNPNIDMACM-IVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGsVAASAIVGYT 407
Cdd:cd17343 309 LFRVHITS--------DSSELFILLLgFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGG-VLAGLPFSYI 379
|
410 420
....*....|....*....|....
gi 490522035 408 VDFFGWDGGFMVMIGGSILAVLLL 431
Cdd:cd17343 380 AKHYDWRTAFLLLEILCAITVVIL 403
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
34-432 |
2.46e-40 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 148.34 E-value: 2.46e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 34 IFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGF 112
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSfGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 113 VPwatsSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWF-NDWHAALY 191
Cdd:cd06174 81 AP----SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 192 MPAFAAILVAIIAFALMRDTPQSCGLPpieaykndypddyneKHEEELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYG 271
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAK---------------NEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 272 ILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKvfrgNRGATGVFFMTLVTIATIVYWLNPPGNPNIDM 351
Cdd:cd06174 222 FSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR----LIGRKPLLLIGLLLMALGLALLLLAPSLLLLL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 352 ACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVLLL 431
Cdd:cd06174 298 LLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
.
gi 490522035 432 I 432
Cdd:cd06174 378 L 378
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
27-434 |
3.99e-34 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 130.77 E-value: 3.99e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 27 RWQIFMGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAA 105
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDlGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 106 VMLFMGFVpwatSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFNd 185
Cdd:cd17319 81 FTALTGFA----TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFG- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 186 WHAALYMPAFAAILVAIIAFALMRdtpqscglppieaykndypddynekheeeltakqifmqyvlpnkLLWYIAIANVFV 265
Cdd:cd17319 156 WRWAFIIEGLLGLLLAVLWWFYLR--------------------------------------------QVWGLALGYFGI 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 266 YLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVFRGNRGATGVFFMTLVTIATIVYWLNppG 345
Cdd:cd17319 192 NYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLT--T 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 346 NPNIDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFG-WDGGFMVMIGGS 424
Cdd:cd17319 270 SPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFV-APLLIGYLVDATGsYTAAFLFLAAVA 348
|
410
....*....|
gi 490522035 425 ILAVLLLIIV 434
Cdd:cd17319 349 LLAALLVLLL 358
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
35-431 |
1.08e-29 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 118.88 E-value: 1.08e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 35 FFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFV 113
Cdd:cd17475 2 TLAQAAASLVAQGIPALAPFLQEDlHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 114 pwatSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLfLLGMAWFNDWHAALYMP 193
Cdd:cd17475 82 ----GSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAAL-LPPLALHYGWRAAFVVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 194 AFAAILVAIIAFALMRDTPQSCGLPPIEAykndypddynekhEEELTAKQifmqyVLPNKLLWYIAIANVFVYLLRYGIL 273
Cdd:cd17475 157 GLVSILAAVLFWLFYREPPAASAATESAS-------------TLLRSLKE-----VLRNRDVWLIAIAGALLVAPQFALL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 274 DWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVFRGNRGATGVFFMTLVTIATIVYWLNPPGNPN-IDMA 352
Cdd:cd17475 219 TFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLwLLVL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 353 CMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLgGSVAASAIVGYTVDF-FGWDGGFMVMIGGSILAVLLL 431
Cdd:cd17475 299 LLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFI-GIAIGPPLFGLLVDAtHSYAPAWLALALLLVLAALLL 377
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
27-444 |
1.04e-28 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 116.52 E-value: 1.04e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 27 RWQIFMGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAA 105
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEfGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 106 VMLFMGFVPwatsSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFnD 185
Cdd:COG2223 83 GLLLLALAV----SYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF-G 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 186 WHAALYMPAFAAILVAIIAFALMRDTPqscglppieaykndypddynekHEEELTAKQIFMQY--VLPNKLLWYIAIANV 263
Cdd:COG2223 158 WRNAFLILGILLLVVAVLAWLFLRDPP----------------------AGAAAAAKASLRDQleALRDPRFWLLSLLYF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 264 FVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVfrgnRGATGVFFMTLVTIATIVYWLNP 343
Cdd:COG2223 216 GTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI----GGRRVLLIVFALMALGLLLLALA 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 344 PGNPNIDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGsVAASAIVGYTVDFFG-WDGGFMVMIG 422
Cdd:COG2223 292 LGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGG-FLGPLLFGALLDATGsYTAAFLVFAV 370
|
410 420
....*....|....*....|..
gi 490522035 423 GSILAVLLLIIVMVGEHKHHHA 444
Cdd:COG2223 371 LALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
34-400 |
1.52e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 115.21 E-value: 1.52e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 34 IFFGYAAYYLVRKNFALAMPYLV--EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMG 111
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLaeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 112 FvpwaTSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFNdWHAALY 191
Cdd:pfam07690 81 F----ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 192 MPAFAAILVAIIAFalmrdtpqscglppieaYKNDYPDDYNEKHEEELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYG 271
Cdd:pfam07690 156 ILAILSLLAAVLLL-----------------LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 272 ILDWSPTYLkEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVFRGNRGATGVFFMTLVTIAtiVYWLNPPGNPNIDM 351
Cdd:pfam07690 219 LLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG--LLLLSLTLSSLWLL 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 490522035 352 ACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA 400
Cdd:pfam07690 296 LALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
24-399 |
2.03e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 106.60 E-value: 2.03e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 24 RRLRWQIFMGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLIL 102
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADlGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 103 AAAVMLFMGFVPwatsSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLgMAW 182
Cdd:COG2814 85 FALGSLLCALAP----SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL-LAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 183 FNDWHAALYMPAFAAILVAIIAFALMRDTPQSCGLPPIEAYKNdypddynekheeeltakqifmqyVLPNKLLWYIAIAN 262
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE-----------------------LLRRPRLLLLLLLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 263 VFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVFRGNRGATGVFFMTLVTIAtivywLN 342
Cdd:COG2814 217 FLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLL-----LA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 490522035 343 PPGNPNIDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVA 399
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
24-434 |
2.68e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 86.45 E-value: 2.68e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 24 RRLRWQIFMGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLIL 102
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAfGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 103 AAAVMLFMGFVPwatsSIMVMFVLLFLCGWFQGMGWPPCGrTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAW 182
Cdd:COG0738 83 MALGLLLFALAP----SYPLLLLALFLLGLGLGLLDVAAN-PYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 183 FNDWHAALYMPAFAAILVAIIAFALMRDTPQScglppieaykndypddynEKHEEELTAKQIFMQYVLPNKLLWYIAIAN 262
Cdd:COG0738 158 GLSLSWHLPYLILAVLLLLLALLFLRSKLPEI------------------EEEEEEAAGSAASLKSLLKNPRLLLGGLAI 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 263 VFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVfrgNRGATGVFFMTLVTIATIVYWLN 342
Cdd:COG0738 220 FLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF---GPVRLLRLSALLAAVGLLLALLA 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 343 PpgNPNIDMACMIVIGFLIyGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFMVMIG 422
Cdd:COG0738 297 P--GPWLALIGLALVGLGL-SLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAI-GPPLIGFLADAFGLRAAFLVPLV 372
|
410
....*....|..
gi 490522035 423 GSILAVLLLIIV 434
Cdd:COG0738 373 CYLLILLLALAL 384
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
75-432 |
1.80e-16 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 80.82 E-value: 1.80e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 75 AYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATS--SIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQK 152
Cdd:cd17342 75 SYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHfyNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKS 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 153 ERGRIVSVWNCAHNVGGGIPPLLflLGMAWFNDWHAALYMPAFAAILVAIIAFalmrdtpqsCGLPPIeaykndypddyn 232
Cdd:cd17342 155 SRGFVLGLWSACASVGNIIGALL--ASSVLDYGYEYAFLVTSSLLFAGAIVVF---------FGLLSS------------ 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 233 ekheeeltakqifmqyvlPNKLLWYiAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWM 312
Cdd:cd17342 212 ------------------PPGVIPY-SLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYI 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 313 SDKVfrGNRGATGVFFMTLVTIATIVYwLNPPGNPNIDMACMIVIGFLIYGPVMLI--------GLHALELAPKKAAGTA 384
Cdd:cd17342 273 SDRM--GSRSPVVVVMLLLAIPSLFVY-SHSPSDKVLNAFVMTITGFFIGGPANLIssaisadlGRQPQLRGSSEALATV 349
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 490522035 385 AGFTGLFGYLGGSVaASAIVGYTVDFFGWDG---GFMVMIGGSILAVLLLI 432
Cdd:cd17342 350 TGIIDGTGSIGAAI-GQVLVPLIQNRLGWMWvfyFFIIMTILTIVCILPLL 399
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
52-432 |
2.22e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 77.21 E-value: 2.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 52 MPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPwatsSIMVMFVLLFLC 130
Cdd:cd17478 19 LPLLIAKlGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAP----NYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 131 GWFQGMGWPPcGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFNDwHAALYMPAFAAILVAIIAFALMRD 210
Cdd:cd17478 95 GIGSAAFHPE-GARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGG-LGLLILLIIPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 211 TPQScglppieaykndyPDDYNEKHEEELTAKQIFmqyvlpnKLLWYIAIANVFVYLLRYGILDWSPTYLKEvKHFALDK 290
Cdd:cd17478 173 KKPE-------------AKKAAAKSSARSTLKGVW-------RALLLLLIIVFLRSWVLSSLTTFLPFYLVQ-RGYSLVF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 291 SSWAYFFYEYAGIPGTLICGWMSDkvfRGNRGATGVFFMTLVTIATIVYWLNPpgnPNIDMACMIVIGFLIYGPVMLIGL 370
Cdd:cd17478 232 AGLLLSLFLFAGAIGTLIGGPLSD---RFGRRRVIIASLLLAAPFLLLFLLTP---GIWSYILLVLAGFLLFASFPVTVV 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490522035 371 HALELAPKKaAGTAAGFTGLFGYLGGSVAAsAIVGYTVDFFGWDGGFMVMIGGSILAVLLLI 432
Cdd:cd17478 306 LAQELLPGN-VGLASGLMMGLSFGLGGIGA-PVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
31-432 |
2.46e-15 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 77.34 E-value: 2.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 31 FMGIFFGYAAYYLVRKNFALAMPYLV-EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLF 109
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIaEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 110 MGFVPwatsSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWHAA 189
Cdd:cd17371 81 CGFAQ----NYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 190 LYMPAFAaILVAIIAFALMRDTPQscglPPIeaykndypddYNEKHEEELTAKQIFMQYVLPNK------LLWyiAIANV 263
Cdd:cd17371 157 RVLFLLG-ALPALLVLFIRRFVKE----PPQ----------WQAARAARRHFADRPSLRELFSPpllrttLLA--SLLAT 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 264 FVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVfrGNRGATGVFFMtlVTIATIVYWLNP 343
Cdd:cd17371 220 GALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI--GRRNNFALFAL--GSAISILLYFFL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 344 PGNPNIDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFMVMIGG 423
Cdd:cd17371 296 PLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGAL-FPFLVGFLATSGSLGTAIAVFAAV 374
|
....*....
gi 490522035 424 SILAVLLLI 432
Cdd:cd17371 375 YYIAGLVLA 383
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
57-434 |
3.22e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 77.22 E-value: 3.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 57 EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPwatsSIMVMFVLLFLCGWFQGM 136
Cdd:COG2807 47 DLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP----SVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 137 GwPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFnDWHAALYMPAFAAILVAIIAFALMRDTPqscg 216
Cdd:COG2807 123 G-NVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAAL-GWRGALAVWALLALLALLLWLPLLRRRP---- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 217 lppieaykndypddynekHEEELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEvKHFALDKSSWAYF 296
Cdd:COG2807 197 ------------------AAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLS 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 297 FYEYAGIPGTLICGWMSDKVfrGNRGATGVFFMTLVTIATIVYWLNPPGNPnidMACMIVIGFLIYGPVMLIGLHALELA 376
Cdd:COG2807 258 LFQLAGIPGSLLVPLLADRL--GDRRPLLLLLGLLGLAGLLGLLLAPGSLP---WLWAVLLGLGQGGLFPLALTLIGLRA 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 377 PKKA-AGTAAGFTGLFGYLGGSVAAsAIVGYTVDFFG-WDGGFMVMIGGSILAVLLLIIV 434
Cdd:COG2807 333 RTPAeAAALSGMAQSVGYLLAALGP-LLVGALHDATGsWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-433 |
1.06e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 75.31 E-value: 1.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 30 IFMGIFFGYAAYYLVRKNFALampYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLF 109
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPL---YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 110 MGFVPwatsSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLgMAWFNDWHAA 189
Cdd:cd17325 78 FAFAT----SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGL-LADALGYRAP 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 190 LYMPAFAAILVAIIAFALMRDTPQScglppieaykndypddyNEKHEEELTAKQIFMQYVLPNKLLWYIAIANVFVYLLR 269
Cdd:cd17325 153 FLVCAALALLALVLALLLLPEPRPP-----------------PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 270 YGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVfrgnrGATGVFFMTLVTIATIVYWLNPPGNPNI 349
Cdd:cd17325 216 GALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI-----GRKPLILIGLLLSAVALLLLPLATSFWL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 350 DMACMIVIGFL--IYGPVMLigLHALELAPKKAAGTAAGFTGLFGYLgGSVAASAIVGYTVDFFGWDGGFMVMIGGSILA 427
Cdd:cd17325 291 LLLLLALLGLGlgLVFPATL--ALLADIVPPEGRGTAMGLFNTAFSL-GMVLGPLLGGFLYDAFGFATPFLAAAALLLLA 367
|
....*.
gi 490522035 428 VLLLII 433
Cdd:cd17325 368 AVLFLL 373
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
31-432 |
1.91e-14 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 74.18 E-value: 1.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 31 FMGIFFGYAAYYLVRKNFALAMPYLVE---QGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVM 107
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 108 LFMGFVPwatsSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWH 187
Cdd:cd17316 81 LLIGLLP----TPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 188 AALYMPAFAAILVAIIAFALMRdtpqscglppieaykndypddynekheeeltakqifmqyvlpnklLWYIAIANVFVYL 267
Cdd:cd17316 157 GWRILFLIGALPALLALLLRRR---------------------------------------------TLLLILLWFFISF 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 268 LRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVfrgNRGATGVFFMTLVTIATIVYWLNPPGNP 347
Cdd:cd17316 192 GYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI---GRKKTLVIGLILSGILALPLFYLLSGSP 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 348 NIDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTVDFFGWDGGFMVMIGGSILA 427
Cdd:cd17316 269 TLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVA 348
|
....*
gi 490522035 428 VLLLI 432
Cdd:cd17316 349 LIVAL 353
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
31-436 |
2.43e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 74.55 E-value: 2.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 31 FMGIFFGYAAYYlvrknfALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPR-----VFLPAGLILAA 104
Cdd:COG2211 19 DLGLNLAFGLLS------AYLLYFYTDVlGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrPWILIGAIPLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 105 AVMLFMGFVPWA--TSSIMVMFVLLFLCGWFQGMGWPPcgrtmvhWWS--------QKERGRIVSVWNCAHNVGGGIPPL 174
Cdd:COG2211 93 LSFVLLFTAPDLspTGKLIYALVTYLLLGLAYTLVNIP-------YSAlgaeltpdYEERTRLSSWRFAFAGLGGLLASV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 175 LFLLGMAWFND-----WHAALYMPAFAAILVAIIAFALMRDTPQscglppieaykndypddyneKHEEELTAKQIFmQYV 249
Cdd:COG2211 166 LPPPLVAAFGGdaalgYRLTALIFAVLGLLAFLLTFFGTKERPV--------------------PEEEKVSLKESL-KAL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 250 LPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVfrGNRGATgVFFM 329
Cdd:COG2211 225 LKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRF--GKKKAF-IIGL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 330 TLVTIATIVYWLNPPGNPNIDMACMIVIGFLiYGPVMLIGL--------HALELAPKKAAGTAAGFTGLFGYLGGSVAAs 401
Cdd:COG2211 302 LLAALGLLLLFFLGPGNLWLLLVLAALAGIG-LGAILVLPWamladvvdYDEWKTGRRREGLYFGIFTFAIKLGQALAG- 379
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 490522035 402 AIVGYTVDFFGWDGG--------FMVMIGGSILAVLLLIIVMV 436
Cdd:COG2211 380 ALAGLLLALFGYVAGaaqspsalTGIRLLFFLLPAVLLLLAAL 422
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
74-438 |
2.09e-13 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 71.58 E-value: 2.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 74 IAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGF-VPWATSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQK 152
Cdd:cd17344 73 FAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLgYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKG 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 153 ERGRIVSVWNcAHNVGGGIppLLFLLGMAWFN-DWHAALYMPAFAAILVAIIAFALMRDTPQScglppieaykndypddy 231
Cdd:cd17344 153 KRGLIMGIWN-SHTSVGNI--LGSLIAGIFVSsAWGLSFIVPGIIIAAMGVLVFLFLVEHPPG----------------- 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 232 nekheeeltakqifmqyVLPNKLLWYiaianvFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGW 311
Cdd:cd17344 213 -----------------VIEFSLCLF------FAKLVSYTFLYWLPLYISNTAILSAKKAGDLSTLFDVGGIVGGILAGY 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 312 MSDKVfrGNRGATGVFFMTLVTIATIVYWLNPPGNPNIDMACMIVIGFLIYGPVMLI--------GLHALELAPKKAAGT 383
Cdd:cd17344 270 ISDYT--GGRATTCAAMLILAAPMLFIYNYFGQVSMTTNIVLLIVCGLLVNGPYALIttavsadlGTHKSLKGNARALAT 347
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 490522035 384 AAGF---TGLFGYLGGSVAASAIVGYtvdffGWDGGFMVMIGGSILAVLLLIIVMVGE 438
Cdd:cd17344 348 VTAIidgTGSIGAALGPLLAGLISSR-----GWNNVFYMLIAADVCAGLLLTRLVYKE 400
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
52-437 |
2.56e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 68.07 E-value: 2.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 52 MPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPR-VFLPAGLILAAAVMLFmgfvPWATSSIMVMFVLLFLC 130
Cdd:cd17355 27 IPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRrVMLLGLLLLAAGLVLL----ALATSLWQLYLLWGLLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 131 GWFQGMGWPPCGRTMVHWWSQKERGRIVSVWncahNVGGGIPPLLFLLGMAWFND---WHAALYMPAFAAILVAIIAFAL 207
Cdd:cd17355 103 GGGAGTLAAVAFATVAAWWFERRRGLALGIL----TAGGGLGSLVFLPLGAALIEafgWRTALLVLALLALLVLVPVLLL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 208 MRDTPQSCGLPpieaykndyPDDYNEKHEEELTAKQIFMqyvlpNKLLWYIAIANVFVYLLRYGILDWSPTYLKEvKHFA 287
Cdd:cd17355 179 LRRRPADLALR---------AYDDASPASPGSTLKEALR-----SASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGIS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 288 LDKSSWAYFFYEYAGIPGTLICGWMSDkvfRGNRGATGVFFMTLVTIATIVYWLNPPGnpnidmacmiviGFLIYGPVML 367
Cdd:cd17355 244 PAAAAVALALIGLFNIVGRLLSGWLGD---RYSPRRLLAASYALRALGLALLLLLPFP------------PLALLLFAAL 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490522035 368 IGLHALELAPKKAAGTAAGF-TGLFGYLGGSVAASAIVGYtvdFFG-WDGGFMVMIGGSILAVLLLIIVMVG 437
Cdd:cd17355 309 FGLGWGATVPLTAALAARYFgARSYGTLFGLVFAPHQLGS---ALGpWLGGLLYDRTGSYTAAWALAVALGL 377
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
28-213 |
1.66e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 65.28 E-value: 1.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 28 WQIFMGIFFGYAAYYLVrknFALAMPYLVE-QGFSRGDLGFALSGISIAYGFSKFIMGSVSDR--SNPRVFLPAGLILAA 104
Cdd:COG2271 183 WLLALAYFLVYFALYGF---LTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlgRRRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 105 AVMLFMGFVPWATSSIMVMFVLLFLCGWFQGMGWPPCGRTMvhwwSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFN 184
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF----PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG 335
|
170 180
....*....|....*....|....*....
gi 490522035 185 dWHAALYMPAFAAILVAIIAFALMRDTPQ 213
Cdd:COG2271 336 -YQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
66-432 |
5.01e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 64.11 E-value: 5.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 66 GFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIMVMFVLLFLCGWFQGMGWPPCGRTM 145
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 146 vhwwSQKERGRIVSVWNCAhNVGGGI--PPLLFLLGMAWfnDWHAALYMPAFAAILVAIIAFALMRDTPQSCGLPpieay 223
Cdd:cd17324 117 ----PPEKRGRAIGLVFSG-LTLGLVlgRPLGGLLGQLL--GWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGS----- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 224 kndYPDDYNEKHeeeltakqifmqyVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGI 303
Cdd:cd17324 185 ---LGLLSSLLL-------------LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 304 PGTLICGWMSDKVFRGnrgaTGVFFMTLVTIATIVYWLNPPGNPNIDMAcMIVIGFLIYGPVMLIGLHALELAPkKAAGT 383
Cdd:cd17324 249 VGSPLAGRLADRGGRR----ALLIALLLLAAALLLLTLLGPSPLLLLVG-LVLWGLGFFAAHSALQTRVLRLAP-EARGL 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 490522035 384 AAGFTGLFGYLGGSVAAsAIVGYTVDFFGWDGGFMVMIGGSILAVLLLI 432
Cdd:cd17324 323 ASSLYLAAYNLGGALGA-ALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
27-435 |
6.62e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 60.70 E-value: 6.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 27 RWQIFMGIFFGYAAYYLVrknFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAA 105
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMV---WPFMAIYLHQQlGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 106 VMLFMGFVpwatSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLL-FLLGMAWFN 184
Cdd:cd17329 78 GFALLGFA----HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLgGLLLLYSFR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 185 dwhAALYMPAFAAILVAIIAFALMRDTPqscglppieaykndypddyNEKHEEELTAKQIFMQYVLPNKLLWYIAIANVF 264
Cdd:cd17329 154 ---LLFLAAAVLFLLAALVLLFLLPETR-------------------PKRRAAEKTEILRGYKIVLRDRAFLLFLLASFL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 265 VYLLRYGILDWSPTYLKEVKHFALDKSSWAYffyeyaGIPGTLICG---WMSDKVFRGNRGATGVFFMTLVTIATIVYWL 341
Cdd:cd17329 212 ISLIYFQLESTLPVYVVEILGLGESLLGLLL------ALNALLIVLlqfPVARLVERFRLRKILMIGILLFAIGFAVLAF 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 342 npPGNPNIDMACMIV--IGFLIYGPVmlIGLHALELAPKKAAGTAAGFTGLFGYLGGsVAASAIVGYTVDFFGWDGGFMV 419
Cdd:cd17329 286 --ANTLAVLILAMIVltLGEMLVFPA--VQTLVAALAPPDKRGSYMGFYALAWGLGR-AIGPLVGGLLLDLLGPGLPWLI 360
|
410
....*....|....*.
gi 490522035 420 MIGGSILAVLLLIIVM 435
Cdd:cd17329 361 LAALGLIAAALLLGLQ 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
6-209 |
9.94e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.90 E-value: 9.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 6 KPAPHRARLPDGEIDPLYRRLRWQIFMGIFFGYAAYYLVRKNFALAMPYLVeqGFSRGDLGFALSGISIAYGFSKFIMGS 85
Cdd:cd17325 180 KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG--GLSPAQIGLLFGAQGLASALSQPPAGK 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 86 VSDRSNPRVFLPAGLILAAAVMLFMGFVPwatsSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAH 165
Cdd:cd17325 258 LSDRIGRKPLILIGLLLSAVALLLLPLAT----SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAF 333
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 490522035 166 NVGGGIPPLlfLLGMAWFNDWHAALYMPAFAAILVAIIAFALMR 209
Cdd:cd17325 334 SLGMVLGPL--LGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-172 |
2.04e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.83 E-value: 2.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 7 PAPHRARLPDGEIDPLYRRLRWQIFMGIFFGYAAYYLVrknFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGS 85
Cdd:COG2814 189 RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFAL---FTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGR 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 86 VSDRSNPRVFLPAGLILAAAVMLFMGFVPwatsSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAH 165
Cdd:COG2814 266 LADRFGRRRLLLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
....*..
gi 490522035 166 NVGGGIP 172
Cdd:COG2814 342 FLGGPLA 348
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
6-211 |
1.43e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 56.42 E-value: 1.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 6 KPAPHRARLPDGEIDPLYRRLRWQIFMGIFFGYAAYYLVrknFALAMPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGS 85
Cdd:COG2807 196 PAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAV---VAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 86 VSDRSNPRvflpAGLILAAAVMLFMGFVPWATSSIMVMFVLLFLCGWFQGmGWPPCGRTMV--HWWSQKERGRIVSVWNC 163
Cdd:COG2807 273 LADRLGDR----RPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQG-GLFPLALTLIglRARTPAEAAALSGMAQS 347
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 490522035 164 AHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFAAILVAIIAFALMRDT 211
Cdd:COG2807 348 VGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGRPY 395
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
24-207 |
2.79e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 55.65 E-value: 2.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 24 RRLRWQIFMGIFFGYAAYYLVRKNFALAMPYLVEQGF--SRGDLGFALSGISIAYGFSKFIMGSVSD-RSNPRVFLPAGL 100
Cdd:cd17474 193 KALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYgiSPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 101 ILAAAVMLFMGFVPwatsSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGM 180
Cdd:cd17474 273 LLYALSLLLLGFVP----SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL 348
|
170 180
....*....|....*....|....*..
gi 490522035 181 AWFNdWHAALYMPAFAAILVAIIAFAL 207
Cdd:cd17474 349 EIFG-LSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
98-436 |
1.49e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.09 E-value: 1.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 98 AGLILAAAVMLFMGFVPWATSSIMVMFVLLFLCGWFQGMGwPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFL 177
Cdd:cd17333 62 RTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGIL-DTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIAT 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 178 LGMAWFNDWHAALYMPAFAAILVAI-IAFALMRDTPQSCglppieaykndypddyneKHEEELTAKQIFMQYVLPNKLLW 256
Cdd:cd17333 141 SLLTSELSWSWAYLIIGLIYLLLAIlILLTLFPELPSAR------------------NPQQSVGAFSASASRLLRNPSII 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 257 YIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVfrgnRGATGVFFMTLVTIA- 335
Cdd:cd17333 203 LGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRI----KPHTLLVLSGSGALLg 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 336 TIVYWLNPPGnpnIDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDG 415
Cdd:cd17333 279 LLILLLAPTL---VVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAI-IPFIMGFIAEAVGIQT 354
|
330 340
....*....|....*....|.
gi 490522035 416 GFMVMIggsILAVLLLIIVMV 436
Cdd:cd17333 355 AMLLIT---ILYAIIFVLALL 372
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
48-434 |
2.84e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 52.23 E-value: 2.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 48 FALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFvpwATSSIMVMFVL 126
Cdd:cd17353 22 WSVFNPPLSSAlGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAF---AISLPLLFLGY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 127 LFLCGWFQGMGWPPCGRTMVHWWSQKeRGRIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFAAILVAIIAFa 206
Cdd:cd17353 99 GVLGGIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAF- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 207 LMRDTPQSCGLPPIEAYKNDYPDDYNEKHEEELTAKQIFMqyvlpnkLLWYIAIANVFVYLLRYGIldwSPTYLKEVKHF 286
Cdd:cd17353 177 LIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPTFW-------LLWLMFFLNATAGLMLIGQ---AKPIGQEFAGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 287 ALDKSSWAYFFYEYAGIPGTLICGWMSDKVFRgNRGATGVFFMTLVTIATIVYWlnpPGNPNIDMACMIVIGFLIYGPVM 366
Cdd:cd17353 247 DAGIAALAVSILSIFNGGGRPFWGWLSDKIGR-KNTLSIAFLIQGVAMFLLPFI---GSVAVLFVLGVALIGFCYGGGFA 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490522035 367 LIGLHALELAPKKAAGTAAGFTgLFGYLGGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVLLLIIV 434
Cdd:cd17353 323 LFPALTADFFGTKNAGTNYGLL-YTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
59-419 |
3.92e-07 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 51.87 E-value: 3.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 59 GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGfvpWATSSIMVMFVLLFLCGwFQGMGW 138
Cdd:cd17341 30 GLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALA---LAVSSYWGLLVLGFLLG-FAGANF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 139 PPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFND------WHAALYMPAFAAILVAIIAFALMRDTP 212
Cdd:cd17341 106 ASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFdggfvgWRNAFFVPGILLAIAAVLVLLFGDDLP 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 213 QScglppieaykndypddyneKHEEELTAKQIFmqYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSS 292
Cdd:cd17341 186 TG-------------------KASALEFLKVQL--AVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 293 WAYFFYEYAGIPGTLICGWMSDKVfrGNRGATGVFFmTLVTIATIVYWLNPPGNPNIDMACMIVigFLIYGPVMLIGLHA 372
Cdd:cd17341 245 ILAALFPLAGALARPAGGWLSDRF--GGRRRLWWLF-IVMTIGAALLSLSLPTSGTNLVLFLAL--FVALGLGAGAGNGS 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 490522035 373 L-ELAP---KKAAGTAAGFTGLFGYLGGSV------AASAIVGYTVDFFGWDGGFMV 419
Cdd:cd17341 320 VfRMVPfifRRELGAVTGLVGAIGGLGGFFlpllfgSSALMTGSGVGAFSLFGVLAV 376
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
59-406 |
4.05e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 51.97 E-value: 4.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 59 GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFvpwATSSIMVMfVLLFLCGWFQGMGW 138
Cdd:TIGR00895 48 GLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCAL---ATNVTQLL-ILRFLAGLGLGGLM 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 139 PPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFnDWHAALYmpaFAAILVAIIAFALMRDTPQSC--- 215
Cdd:TIGR00895 124 PNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVF-GWRSLFY---VGGIAPLLLLLLLMRFLPESIdfl 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 216 ---GLPPIEAYKNDYPDDYNEKHEEEL--------TAKQIFM-----QYVLPNKLLWYIAIANVFVYllrYGILDWSPTY 279
Cdd:TIGR00895 200 vskRPETVRRIVNAIAPQMQAEAQSALpeqkstqgTKRSVFKalfqgKTARITVLLWLLYFMLLVGV---YFLTNWLPKL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 280 LKEVKhFALDKSSWAYFFYEYAGIPGTLICGWMSDKVfrgNRGATGVFFMTLVTIATIVYwlNPPGNPNIDMACMIVIGF 359
Cdd:TIGR00895 277 MVELG-FSLSLAATGGALFNFGGVIGSIIFGWLADRL---GPRVTALLLLLGAVFAVLVG--STLFSPTLLLLLGAIAGF 350
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 490522035 360 LIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAAsAIVGY 406
Cdd:TIGR00895 351 FVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGP-ILAGY 396
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
57-436 |
6.81e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 51.05 E-value: 6.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 57 EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFvpwaTSSIMVMFVLLFLCGWFQGM 136
Cdd:cd17365 28 DWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAF----AQSVLQLALLRFLTGLGLGA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 137 GWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFNdWHAALYMPAFAAILVAIIAFALMrdtpqscg 216
Cdd:cd17365 104 AMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG-WRSVFLLGGVPPLILLPLLRGTL-------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 217 lppieaykndypddynekheeeltakqifmqyvlpnkLLWYIAIANVFVYllrYGILDWSPTYLKEVKhFALDKSSWAYF 296
Cdd:cd17365 175 -------------------------------------LLWVTFFMGLLLV---YLLNSWLPKLMVEAG-YSLSQALTITL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 297 FYEYAGIPGTLICGWMSDKvFRGNRGATGVFFMTLVTIATIvywLNPPGNPNIDMACMIVIGFLIYGPVMLIGLHALELA 376
Cdd:cd17365 214 LLNIGGVIGSLLLGWLADR-FGPKRVLALFFALGAVSLALL---GVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFY 289
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490522035 377 PKKAAGTAAGFTGLFGYLgGSVAASAIVGYTVDF-FGWDGGFMVMIGGSILAVLLLIIVMV 436
Cdd:cd17365 290 PTEVRATGVGWALGVGRL-GAILGPLLGGLLLAAgLGPESVFLALAIPAALGALAVLLLRL 349
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
30-207 |
9.04e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 50.69 E-value: 9.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 30 IFMGIFFGYAAYYLVrknfalAMPYLVEQ--GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVM 107
Cdd:cd06173 215 LALALFALLGGALTV------LLPLLAKEvlGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 108 LFMGFVPwatsSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNcahNVGGGIPPLLFLLG--MAWFND 185
Cdd:cd06173 289 LVLGLSP----SLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYN---ALNSGAMPLGALLAglLADALG 361
|
170 180
....*....|....*....|..
gi 490522035 186 WHAALYMPAFAAILVAIIAFAL 207
Cdd:cd06173 362 LSAVFLLAGALLLLAALLLLLL 383
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
59-212 |
1.59e-06 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 50.31 E-value: 1.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 59 GFSRGDLGFAlsGISIAYG--FSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIMVMFVLLFlcgwfqgm 136
Cdd:PLN00028 67 NLTKSDIGNA--GIASVSGsiFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGF-------- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 137 gwppCGRTMV---HWWSQKERGRIVSVWN-CAH---NVGGG----IPPLLFLLGMAWFND----WHAALYMPAFAAILVA 201
Cdd:PLN00028 137 ----SLATFVscqYWMSTMFNGKIVGTANgIAAgwgNLGGGvtqlLMPLVFPLIKDAGAPsftaWRIAFFVPGLLHIIMG 212
|
170
....*....|.
gi 490522035 202 IIAFALMRDTP 212
Cdd:PLN00028 213 ILVLTLGQDLP 223
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
1-207 |
1.78e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.88 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 1 MLSIFKPAPHRARLPDG---EIDPLYRRLRWQIFMGIFFGYAAYYLVrknfALAMPYLVE--QGFSRGDLGFALSGISIA 75
Cdd:cd17473 170 LLFLPEPARKSKSAASPgaaTAAALPWKRVLPIYFLAFLAMLLFYVI----PIQLPFLLQerGGGSAALIGLALAIASLA 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 76 YGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFvpwaTSSIMVMFVLLFLCGWFQGMGWPpcgrTMVHWWSQ---- 151
Cdd:cd17473 246 GAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLAL----ASGLWVVLLGAILAGLGFGLLLP----TLNSWAMSlvpp 317
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 490522035 152 KERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFAAILVAIIAFAL 207
Cdd:cd17473 318 ELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
31-314 |
2.71e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 49.09 E-value: 2.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 31 FMGIFFGYAAyylvRKNFALAMPYLV-EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLF 109
Cdd:cd17380 5 FLATCICYAD----RVNMPIAIVPMAkEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 110 MGFVPWatSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVG----GGIPPLLfllgMAWFNd 185
Cdd:cd17380 81 TPLLAY--SSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGtllgGLIGPLL----LEYYG- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 186 WHAALYMPAFAAILVAIIafalmrdtpqscglppieaykndypddynekheeeltakqiFMQYVLPnklLWYIAIANVFV 265
Cdd:cd17380 154 WPSVFYFFGLLGLLWALV-----------------------------------------WLIYLPP---VWAIIVAHFCM 189
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 490522035 266 YLLRYGILDWSPTYLKEVkhFALDKSSWAYFFYEY-AGIPGTLICGWMSD 314
Cdd:cd17380 190 NWGFYILLSWLPTYFHEV--LVPLAKGWVFNVVPWlVMFPSSNVAGWLAD 237
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
52-207 |
5.65e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 48.42 E-value: 5.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 52 MPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWaTSSIMVMFVLLFLCG 131
Cdd:cd17355 234 VPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPF-PPLALLLFAALFGLG 312
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490522035 132 WFQGMgwPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFAAILVAIIAFAL 207
Cdd:cd17355 313 WGATV--PLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
22-205 |
5.80e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.98 E-value: 5.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 22 LYRRLRWQIFMGIFFGYAAYYLvrknFALAMPYLVEQ--GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAG 99
Cdd:cd17316 174 LLRRRTLLLILLWFFISFGYYG----LTTFLPTYLQTvlGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIG 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 100 LILAAAVMLFMGFvpWATSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSV-WNCAHNVGGGIPPLLFLL 178
Cdd:cd17316 250 LILSGILALPLFY--LLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLsYNLGRLGGGGAPPLIALL 327
|
170 180
....*....|....*....|....*..
gi 490522035 179 gMAWFNDWHAALYMPAFAAILVAIIAF 205
Cdd:cd17316 328 -LASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
22-206 |
5.86e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 48.31 E-value: 5.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 22 LYRRLRWQIFMGIFFGYAAYYLVrknFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGL 100
Cdd:cd17324 195 LRNPRLRLAYLITFLLFGGFFAL---YTYLAPFLTDVpGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALL 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 101 ILAAAVMLFMGFVPWatssIMVMFVLLFLCGWFQGMGwPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFllGM 180
Cdd:cd17324 272 LLAAALLLLTLLGPS----PLLLLVGLVLWGLGFFAA-HSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALG--GL 344
|
170 180
....*....|....*....|....*.
gi 490522035 181 AWFNDWHAALYMPAFAAILVAIIAFA 206
Cdd:cd17324 345 VLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
30-435 |
6.79e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.97 E-value: 6.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 30 IFMGIFFGYAAYYLVrknFALAMPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLF 109
Cdd:cd17489 1 ILLANFFFFLSFYLL---LPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 110 MGFVPwatsSIMVMFVLLFLcgwfQGMGW---PPCGRTMVHWWSQKER-GRIVSVWNCAHNVGGGIPPLLFLLGMAWFNd 185
Cdd:cd17489 78 YLLAT----SVALLLVLRLI----HGIGWgafTTAAATLVADIIPPSRrGEGIGYYGLATTLAMALGPALGLFLYQHLG- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 186 wHAALYMPAFAAILVAIIAFALMRDTPQScglppieaykndypddyneKHEEELTAKQIFMQYVlpNKLLWYIAIANVFV 265
Cdd:cd17489 149 -FAVLFIVAAVLALLALLLVFLVKDPPPV-------------------AAEEAEAGTRAFRRLV--EKKVLPPALILFLA 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 266 YLLRYGILDWSPTYLKEVKHfaldkSSWAYFFYEYAGipGTLICGWMSDKVF-RGNRGATGVFFMTLVTIATIVYWlnpp 344
Cdd:cd17489 207 SIAYGAISTFLPLYAAERGI-----SNAGLFFTVYAI--ALLLSRPFSGKLSdRKGPKTVIIPGLLLLALGLLLLS---- 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 345 gnpNIDMACMIVIGFLIYG----PVML-IGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFmv 419
Cdd:cd17489 276 ---FAGSPWMLLLAAVLYGlgfgLLFPaLQALAVDLVPPHRRGAANGTFFIFFDLGIGL-GGLLLGLVAELFGYRAMF-- 349
|
410
....*....|....*.
gi 490522035 420 mIGGSILAVLLLIIVM 435
Cdd:cd17489 350 -LLAAVVVLLALVLYI 364
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
18-207 |
8.45e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 47.50 E-value: 8.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 18 EIDPLYRRLRWQIFMGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFL 96
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADlGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 97 PAGLILAAAVMLFMGFVPwatsSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLF 176
Cdd:COG0477 83 LIGLLLFGLASLLCGLAP----SPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158
|
170 180 190
....*....|....*....|....*....|.
gi 490522035 177 LLGMAWFnDWHAALYMPAFAAILVAIIAFAL 207
Cdd:COG0477 159 GLLVAAL-GWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
28-205 |
1.46e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 47.04 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 28 WQIFMGIFFGYAAYYLVrkNFALAMPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLpagLILAAAVM 107
Cdd:cd06174 206 WLLLLAIFLVNLAYYSF--STLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPL---LLIGLLLM 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 108 LFMGFVPWATSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWH 187
Cdd:cd06174 281 ALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLT 360
|
170
....*....|....*...
gi 490522035 188 AALYMPAFAAILVAIIAF 205
Cdd:cd06174 361 GAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
51-436 |
4.46e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 45.64 E-value: 4.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 51 AMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAvmlfMGFVPWATSSIMVMFVLLFL 129
Cdd:cd17320 21 ALPAIARDlGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFIL----ASLLCALASSIEQLLIARFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 130 cgwfQGMGWPPC---GRTMVH-WWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFnDWHAALYMPAFAAILVAIIAF 205
Cdd:cd17320 97 ----QGLGAAAGsvvARAIVRdLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFF-GWRAIFVFLALLGLLLLLLVL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 206 ALMRDTPQscglppieaykndypddyneKHEEELTAKQIFMQY--VLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEV 283
Cdd:cd17320 172 LFLPETLP--------------------EEKRKPLLSSLLRAYkrVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQ 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 284 KHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVFRGNRGATGVFFMTLVTIATIVYWLNPPGNPNIDMACMIVIGF---L 360
Cdd:cd17320 232 LGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFgfgL 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490522035 361 IYGPVMLIGLHALelapKKAAGTAAGFTGLFGYLGGSVAASAIVgytvdfFGWDGGFMVMIGGSILAVLLLIIVMV 436
Cdd:cd17320 312 IFPNATSLALEPF----PHVAGTASALLGFLQFLIGALAGALVG------LLPNGTALPMGLLILVLGLLALLLLI 377
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
152-412 |
5.37e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 45.30 E-value: 5.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 152 KERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFAAILVAIIAFALMRDTPQSCGLPPIEAYK--NDYPD 229
Cdd:cd17328 119 EKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKStaTSFLA 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 230 DynekheeeltakqifMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLK---EVKHFALDKSSWAYFFYE-YAGIPG 305
Cdd:cd17328 199 D---------------LKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLrafGVGDLSSADVGLIFGAITcIAGVLG 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 306 TLICGWMSDKVFRGNRGA---TGVFFMTLVTIATIVYWLNPPGNPNIDMACMIVIGFLIYGPVMLIGLHALELAPKKAAG 382
Cdd:cd17328 264 VLLGGILADRLRRKTPRAdplVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRS 343
|
250 260 270
....*....|....*....|....*....|
gi 490522035 383 TAAGFTGLFGYLGGSVAASAIVGYTVDFFG 412
Cdd:cd17328 344 TASAIQILLSHLLGDAGSPYLIGLISDLLR 373
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
49-405 |
1.04e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.09 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 49 ALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPwatsSIMVMFVLL 127
Cdd:cd17321 16 NVALPTIARDlGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP----SLAFLIAAR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 128 FLcgwfQGMG---WPPCG-RTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLL--FLLgmaWFNDWHAALYMPAFAAILVA 201
Cdd:cd17321 92 AL----QGIGaaaIMPASlALIAATFPGERRGRALGLWGAVVGIGAALGPLLggLLL---ELFGWRWIFLINVPIGLVAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 202 IIAfalmrdtpqscglppieaykndypddynekheeeltakqifmqyvlpnKLLWYIAIANVFVYLLRYGILDWSPTYLK 281
Cdd:cd17321 165 LLA------------------------------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQ 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 282 EVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVfrGNRgATGVFFMTLVTIATIVYWLNPPGNPNIDMAC-MIVIGF- 359
Cdd:cd17321 197 GVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRF--GPR-LVLVAGLLLTAVGLLLLALLGADSSVWLLLPgLVLLGLg 273
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 490522035 360 --LIYGPVMLIglhALELAPKKAAGTAAGFTGLFGYLGGSVAAsAIVG 405
Cdd:cd17321 274 lgLFATPLTNA---ALSSVPKEKAGAASGILNTARQLGGALGV-ALLG 317
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
54-433 |
1.13e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.14 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 54 YLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPR-VFLPAGLILAAAVMLFMGFVPWATSSIMVMFVLLFLCGW 132
Cdd:cd06173 25 LVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 133 FQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIPPLL--FLLGmawFNDWHAALYMPAFAAILVAIIAFALMRD 210
Cdd:cd06173 105 ASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALggLLVA---LLGPGGAFAINALSFLLSALLLLFIRRP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 211 TPQSCGlppieaykndypddynEKHEEELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDK 290
Cdd:cd06173 182 PPAAPG----------------ESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 291 SSWAYFFYEYAGIPGTLICGWMSDKVfrgNRGATGVFFMTLVTIATIVYWLNPpgNPNIDMACMIVIGFLIygPVMLIGL 370
Cdd:cd06173 246 YGLLLAAFGVGALLGALLLGRLSKRR---RRGRLLLIGALLLGLALLVLGLSP--SLWLLLAALFLLGLAG--GLFNVPL 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490522035 371 HAL--ELAPKKAAGTAAGFTGLFGYlGGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVLLLII 433
Cdd:cd06173 319 NTLlqLRVPDELRGRVFSVYNALNS-GAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
59-430 |
2.45e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 43.02 E-value: 2.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 59 GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWAtssiMVMFVLLFLCGWFQGMgw 138
Cdd:cd17393 30 GLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSV----PALALALFLFGAANGA-- 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 139 ppCGRTMVHWWSQKERGRIVSVWNCAHNVG--GGIPPLLFLLGMAWFNDWHAALYMPAFAAILVAIIAF--ALMRDTPQS 214
Cdd:cd17393 104 --LDVAMNAQGVAVERAYGRPIMSSLHAMWslGGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAALVAirALLPGTGEA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 215 CGlppieaykndypddynekHEEELTAKQIFmqyVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWA 294
Cdd:cd17393 182 AE------------------DRPDGAGKPGF---LLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 295 YFFYEYAGIPGTLICGWMSDKVfrgNRGATGVFFMTLVTIATIVYWLNPpgNPNIDMACMIVIGFLIYGPVMLIgLHALE 374
Cdd:cd17393 241 YAVFSLAMTVGRLFGDRLVDRF---GDVAVLRAGALLAALGLLLALLAP--SVWVALAGFALMGLGLSVVVPLA-FSAAG 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 490522035 375 LAPKKAAGTAAGFTGLFGYLgGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVLL 430
Cdd:cd17393 315 ALPGLAAGIAVARVATLGYL-GFLVGPPLIGFLADATGLRTAFLVVALLALLVALL 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
251-449 |
2.77e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.04 E-value: 2.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 251 PNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVkHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVfrgNRGATGVFFMT 330
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRF---GRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 331 LVTIATIVYWLNPpgNPNIDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAAsAIVGYTVDF 410
Cdd:COG2814 84 LFALGSLLCALAP--SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGP-LLGGLLADL 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 490522035 411 FGWDGGFMVMIGGSILAVLLLIIVMVGEHKHHHATLAKR 449
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS 199
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
258-434 |
2.80e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.79 E-value: 2.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 258 IAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVfrgnrGATGVFFMTLVTIATI 337
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF-----GRRRVLLIGLLLFALG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 338 VYWLNPPGNPNIDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAAsAIVGYTVDFFGWDGGF 417
Cdd:pfam07690 76 LLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGP-LLGGLLASLFGWRAAF 154
|
170
....*....|....*..
gi 490522035 418 MVMIGGSILAVLLLIIV 434
Cdd:pfam07690 155 LILAILSLLAAVLLLLP 171
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
93-431 |
3.21e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.55 E-value: 3.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 93 RVFLPAGLILAAAVMLFMgfvpwATSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGIP 172
Cdd:cd17477 62 RAFAAGAAITAVSVLLLA-----LTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 173 PLLfllgMAWFNDWHAALYMPAFAAILVAIIAFALMRDTPqscglPPIEAykndypddynekhEEELTAKQIFMQYVLpn 252
Cdd:cd17477 137 PLL----LALVGTAGALPFLIAAVLLLLALVPLLLTRRAA-----PEIEE-------------AESISLRRLLRIAPL-- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 253 kllwyiAIANVFVY-LLRYGILDWSPTYLKEVkHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVfrgNRGATGVFFMTL 331
Cdd:cd17477 193 ------ALLGAFVAgFLEGAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRF---DRRRVLLGCALL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 332 VTIATIVYWLNPPGNPNIdMACMIVIGFLIYG--PVMLIglHALELAPKKAAGTAAGFTGLFgYLGGSVAASAIVGYTVD 409
Cdd:cd17477 263 GALAALLLPLVPGLPLAL-LVLLFLWGGAAGPlyTLALA--LAGDRLPGDELVAANAALLLL-YGLGSVIGPLLAGALMD 338
|
330 340
....*....|....*....|..
gi 490522035 410 FFGWDGGFMVMIGGSILAVLLL 431
Cdd:cd17477 339 AFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
11-205 |
5.82e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 42.13 E-value: 5.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 11 RARLPDGEidpLYRRLRWQIF--MGIFFGYAAYYLVRKNFALAmpYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVS 87
Cdd:cd17369 214 VVRAPLVE---VLRRHWRALLlaIGLRLAENVLFYLFTTFALS--YATQTlGVDRSTVLLAVLIASVVAAITIPLFGWLS 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 88 DRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSV-WNCAHN 166
Cdd:cd17369 289 DRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLgYQLGAI 368
|
170 180 190
....*....|....*....|....*....|....*....
gi 490522035 167 VGGGIPPLLFLLGMAWFNDWHAALYMPAFAAILVAIIAF 205
Cdd:cd17369 369 LGGGFAPLIATALVAATGSWWPVALYLAALAVISLVAAL 407
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
66-433 |
6.26e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 41.84 E-value: 6.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 66 GFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAavmLFMGFVPWATS-SIMVMFVLLFLCGWFQGMGWPPCGRT 144
Cdd:cd17318 59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITA---LLTLLTPLAARgGYGALIVLRILQGLAQGVTFPAMHAL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 145 MVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFNdWHAALYMPAFAAILVAIIAFALmrdtpqscglppieayk 224
Cdd:cd17318 136 WAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLG-WPSIFYIFGGLGLLWCLLWFFL----------------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 225 ndypddynekheeeltakqifmqyVLPnklLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDK----SSWAYFfyey 300
Cdd:cd17318 198 ------------------------VLP---VWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSngflSSLPYL---- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 301 AGIPGTLICGWMSDK-VFRGNRGATGV--FFMTLVTIativywlnppgnpnIDMACMIVIGFLIYGPVMLI-------GL 370
Cdd:cd17318 247 AMWICSIVGGYLADWlRSRGILSTTTVrkLFTSIGFL--------------GPGVFLIALGYLGSNATLAVvfltlsvGL 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490522035 371 HA----------LELAPKkAAGTAAGFTGLFGYLGGSVaASAIVGYTV----DFFGWDGGFMVMIGGSILAVLLLII 433
Cdd:cd17318 313 SGacysgflvnhLDLAPN-YAGTLMGITNTAATIAGII-SPLIVGAIVkndqTIGQWRIVFFISAAIYILGAIFYLI 387
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
28-208 |
1.72e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.66 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 28 WQIFMGIFFGYAAYYLvrknfalampylveqGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVM 107
Cdd:COG2211 244 LALVAALLLYYFKYVL---------------GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 108 LFMGFVPWatSSIMVMFVLLFLCGWFQGMGWpPCGRTMV-------HWWSQKER-GRIVSVWNCAHNVGGGIPPLLFLLG 179
Cdd:COG2211 309 LLLFFLGP--GNLWLLLVLAALAGIGLGAIL-VLPWAMLadvvdydEWKTGRRReGLYFGIFTFAIKLGQALAGALAGLL 385
|
170 180 190
....*....|....*....|....*....|....*
gi 490522035 180 MAWFNDW------HAALYMPAFAAILVAIIAFALM 208
Cdd:COG2211 386 LALFGYVagaaqsPSALTGIRLLFFLLPAVLLLLA 420
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
50-435 |
2.27e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 39.98 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 50 LAMPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPR-----VFLPAGLILAAAVMLFMGFVPWATSSIMVMF 124
Cdd:pfam13347 20 LLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRwgrrrPWLLLSAIILAVSFILLFTPPELGRAPLFIW 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 125 VLLFLCGWFQGMGW---PPCGRTMVHWWSQKERGRIVSVWNCAHNVGGG----IPPLLFLLGMAWFNDWHAALYMPAFAA 197
Cdd:pfam13347 100 LLATYILLRIAYTFfeiPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLlaaaLAFPLVLILGGTGLERKGYRIFALIGA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 198 ILVAIIAFAlmrdtpQSCGLPPIEAYKNDYPddynekhEEELTAKQIFMQY--VLPNKLLWYIAIANVFVYL---LRYGI 272
Cdd:pfam13347 180 VLMLLGVII------TAAGTKERVSMRSKED-------TGQKEAGSLLDMLkeVFRNRAFLILLASFLLAALamgVLNGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 273 LDWSPTYLKEvkhfALDKSSWAYFFYEYAGIPGTLICGWMSDKVfrGNRGAtgVFFMTLVTIA--TIVYWLnPPGNPNID 350
Cdd:pfam13347 247 LLYYFRYVLG----NGFAASAFPLVFTIGALLGIPLWPPLAKRI--GKKNT--YILGALITIAgfALALLL-GPNNTLLF 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 351 MACMIVIGFlIYGPVMLIGLHAL--------ELAPKKAAGTAAGFTGLFGYLGGSVAAsAIVGYTVDFFGWDGGFMVMIG 422
Cdd:pfam13347 318 LVLYIIIGF-GYGSSFFLPWSMLadvvdygeLRTGKRREGTFFAMWSFISKLATGVGL-GVSGLLLSAFGYNAGDSVQSP 395
|
410
....*....|...
gi 490522035 423 GSILAVLLLIIVM 435
Cdd:pfam13347 396 QAVTAIRLLYAVL 408
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
31-203 |
2.65e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.91 E-value: 2.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 31 FMGIFFGYAAYYLVRKNFALAMP-----YLVEQGFSRGDLGFALSGISIAYGFSKFIMGS-VSDRSNPR-----VFLPAG 99
Cdd:cd17328 209 FILSTLGFTAVSFVTGALAFWAPtfflrAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGiLADRLRRKtpradPLVCAV 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 100 LILAAAVMLFMGFVpWATSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWN-CAHNVGGGIPPLLFLL 178
Cdd:cd17328 289 GLLAAAPFLFLALV-LALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQIlLSHLLGDAGSPYLIGL 367
|
170 180 190
....*....|....*....|....*....|....*.
gi 490522035 179 -----------GMAWFNDWHAALYMPAFAAILVAII 203
Cdd:cd17328 368 isdllrqnkdsPLAEAASLQYALLLCSFVLVLGGFF 403
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
30-136 |
3.85e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.46 E-value: 3.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 30 IFMGIFFGYAAYYLVrknFALAMPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVF-LPAGLILAAAVML 108
Cdd:cd17352 188 LALGVSFAMLGFFVP---FVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLyLYIFTLLILGLSL 264
|
90 100
....*....|....*....|....*....
gi 490522035 109 FMGFVPWATSSIMVMFVLLFLC-GWFQGM 136
Cdd:cd17352 265 LAFPLATTYVGLIVFSVLFGFCsGSYSSL 293
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
30-205 |
4.77e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.16 E-value: 4.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 30 IFMGIFFGYAAYylvrknfaLAMpYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVML 108
Cdd:cd17341 216 VTFGSFVGFSNV--------LPT-YFKTRfGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAA 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 109 FMGFVPWATSSIMVMFVLLFLC-GWFQGMGwppCGRT--MVHWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFND 185
Cdd:cd17341 287 LLSLSLPTSGTNLVLFLALFVAlGLGAGAG---NGSVfrMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGS 363
|
170 180
....*....|....*....|
gi 490522035 186 WHAALYMPAFAAILVAIIAF 205
Cdd:cd17341 364 GVGAFSLFGVLAVACTLLVW 383
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
65-212 |
5.11e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 38.96 E-value: 5.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 65 LGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAavmLFMGFVPWATSsimVMFVLLFLCGWFQGMGWP---PC 141
Cdd:TIGR00894 78 QGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSS---VISIVIPWAAG---GGIALVVFCRVIQGLAQGsvsPA 151
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490522035 142 GRTM-VHWWSQKERGRIVSvwncAHNVGGGIPPLLFLLGMAWFND----WHAALYMPAFAAILVAIIAFALMRDTP 212
Cdd:TIGR00894 152 THKIiVKWAPPKERSRLLG----MSTSGFQLGTFIFLPISGWLCEswggWPMIFYVFGIVGCAWSLLWFVFPADDP 223
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
252-434 |
5.47e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 38.71 E-value: 5.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 252 NKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFFYEYAGIPGTLICGWMSDKVFRGNRGATGVFFMTL 331
Cdd:cd17474 197 GRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 332 VTIATIVYWLNPPgnpnidmacMIVIGFLIYGPVMLIGLHAL-----ELAPKKAAGTAAGFTGLFGYLGGSVAASAIvGY 406
Cdd:cd17474 277 LSLLLLGFVPSLA---------LLLIAIVLFGLGLGLNLPLLttlvtELAPEEERGTASSLYNFVRFLGQAVGPLLF-GL 346
|
170 180
....*....|....*....|....*...
gi 490522035 407 TVDFFGWDGGFMVMIGGSILAVLLLIIV 434
Cdd:cd17474 347 LLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
32-171 |
6.05e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.71 E-value: 6.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 32 MGIFFGYAAYYLVrknFALAMPYLVE-QGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFM 110
Cdd:cd17503 185 LLSFLLGLGLFGA---MFLLPLYLQNvLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLL 261
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490522035 111 GFVPwATSSIMVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGGI 171
Cdd:cd17503 262 AFLT-PDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSI 321
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
48-208 |
6.16e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 38.75 E-value: 6.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 48 FALAMPYLVEQGFSRGDLGFaLSGI--SIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSI--MVM 123
Cdd:cd17485 227 LAMLPPFLVDRGFSLSQIGL-LSGVggSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALGGSGLnwVLL 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 124 FVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGRIVSVWNCAHNVGGgippLLFLLGMAWFNDWHAalYMPAFAAILVAII 203
Cdd:cd17485 306 LASLALLHLVGGMITTALFTLMMDCSQQAQAGTDYTLLATVEVLGK----LLFGSLAGFLADHLG--YAAAFLLFAILSA 379
|
....*
gi 490522035 204 AFALM 208
Cdd:cd17485 380 LSVLL 384
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
53-432 |
7.34e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.29 E-value: 7.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 53 PYLVEQGFSRGDLGFALS-GISIAYgFSKFIMGSVSDRSNPR-VFLPAGLILAAAVMLFMGFvpwATSSIMVmFVLLFLC 130
Cdd:cd17370 24 LFLVVLGASAAAVGLIEGlAEALGS-LLRLFSGYLSDRTGKRkPLVILGYGLSALAKPLLAL---AGSWQLV-LLLRILE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 131 GWFQGMGWPPcGRTMV-HWWSQKERGRIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFAAILVAIIAFALMR 209
Cdd:cd17370 99 RLGKGIRTPP-RDALLaDATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNYRTIFLLAAIPALLALLILLFVV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 210 DTPqscglppieaykndypddyneKHEEELTAKQIFMQYVLPNKLLWyiaIANVFVYLLRYGILDWS-PTYLKEVKHFAL 288
Cdd:cd17370 178 KEY---------------------PRPPKLRKKSKKTSLKKLPKAFW---LYLLAVALFALGNFSFAfLILRAQELGLSA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490522035 289 DKSSWAYFFYEYAGIPGTLICGWMSDKVfrgnrGATGVFFMTLVT--IATIVYWLNPPgnpnidmACMIVIGFLIYGPVM 366
Cdd:cd17370 234 ALIPLLYALFNLVYALAAYPAGRLSDRI-----GRKKLLILGYLSlaLAYLGFALGSS-------LWLLLLGFILWGLYM 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490522035 367 liGLH-------ALELAPKKAAGTAAG-FTGLFGYlgGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVLLLI 432
Cdd:cd17370 302 --GAQesieraaVADLVPAELRGTAYGlFNTVVGI--GWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| |
