|
Name |
Accession |
Description |
Interval |
E-value |
| CMAS |
pfam02353 |
Mycolic acid cyclopropane synthetase; This family consist of ... |
110-370 |
1.01e-114 |
|
Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.
Pssm-ID: 396777 [Multi-domain] Cd Length: 272 Bit Score: 335.45 E-value: 1.01e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 110 KDVQSHYDIGNDFYRLWLDKTMTYSCAYFEHDDDTLEQAQLNKVRHILHKLNPVSGKRLLDIGSGWGTLIFMAAEEFGLH 189
Cdd:pfam02353 7 ENIQAHYDLSNDFFALFLDPTMTYSCAYFERPDMTLEEAQQAKLDLILDKLGLKPGMTLLDIGCGWGGLMRRAAERYDVN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 190 ATGITLSKEQYDYTQQQIKERGLEDKVNVLLTDYREVKDQFDYVTSVGMFEHVGKENLGLYFQDVEKFLVPDGRALIHGI 269
Cdd:pfam02353 87 VVGLTLSKNQYKLARKRVAAEGLARKVEVLLQDYRDFDEPFDRIVSVGMFEHVGHENYDTFFKKLYNLLPPGGLMLLHTI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 270 TGQH-----EGAGVDPFLNKYIFPGGYIPNVAENLTHIMNAGLQLTDLEPLRRHYQKTLEIWYDNYVKVIDQAEAKYGKP 344
Cdd:pfam02353 167 TGLHpdetsERGLPLKFIDKYIFPGGELPSISMIVESSSEAGFTVEDVESLRPHYAKTLDLWAENLQANKDEAIALQSEE 246
|
250 260
....*....|....*....|....*.
gi 490601742 345 FTRMWSLYLQGAAASFEAGNIDVMQY 370
Cdd:pfam02353 247 FYRMWMLYLTGCAVAFRIGYIDVHQF 272
|
|
| cyclopro_CfaB |
NF040703 |
C17 cyclopropane fatty acid synthase CfaB; |
13-389 |
5.02e-109 |
|
C17 cyclopropane fatty acid synthase CfaB;
Pssm-ID: 468667 [Multi-domain] Cd Length: 393 Bit Score: 325.41 E-value: 5.02e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 13 HAFDIPVSVTYWNGKTENYGGDnPQVKIEIKKEIPLKEMTsQPTL-VLGEAYMNGDIDITGSIEELVASAYRKGGSFLTN 91
Cdd:NF040703 10 RNLQLPLRLRLWDGKQLDLGPS-PRVTLVVKDPSLLSQLT-HPSLdLLGSAYVEGRLDLEGPIMEVIRVGDELSQALLGD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 92 NPFLKHlPKISHSEKESKKDVQSHYDIGNDFYRLWLDKTMTYSCAYFEHDDDTLEQAQLNKVRHILHKLNPVSGKRLLDI 171
Cdd:NF040703 88 DDEAPP-ERTAHDKATDAAAISYHYDLSNDFYALWLDPDMVYSCAYFETGTEDLAQAQQAKLRHLCRKLRLQPGERLLDV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 172 GSGWGTLIFMAAEEFGLHATGITLSKEQYDYTQQQIKERGLEDKVNVLLTDYREV--KDQFDYVTSVGMFEHVGKENLGL 249
Cdd:NF040703 167 GCGWGGLARFAAREFGVEVFGITLSKEQLKLARERVAAEGLQDRVQLELLDYRDLpqDGRFDKVVSVGMFEHVGHANLPL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 250 YFQDVEKFLVPDGRALIHGITGQH-------EGAGvdPFLNKYIFPGGYIPNVAENLTHIMNAGLQLTDLEPLRRHYQKT 322
Cdd:NF040703 247 YCQRLFGAVRPGGLVMNHGITARHtdgrpvgRGAG--EFIGRYVFPHGELPHLATITASISEAGLEVVDVESLRLHYART 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490601742 323 LEIWYDNYVKVIDQAEAKYGKPFTRMWSLYLQGAAASFEAGNIDVMQYLLTK--APSGTGLPMTRQYVY 389
Cdd:NF040703 325 LEHWSARLEARLDEAARLVPERALRIWRLYLAGCAYGFARGWINLHQILAVKplADGSHELPWTRADLY 393
|
|
| PRK11705 |
PRK11705 |
cyclopropane fatty acyl phospholipid synthase; |
4-374 |
1.74e-88 |
|
cyclopropane fatty acyl phospholipid synthase;
Pssm-ID: 183282 Cd Length: 383 Bit Score: 272.49 E-value: 1.74e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 4 KTVYKELLSHAfDIPVsvtywngktenyGGDNPQvKIEIKKEIPLKEMTSQPTLVLGEAYMNGDIDITgSIEELVASAYR 83
Cdd:PRK11705 17 YRIANELLARA-GITI------------NGSRPW-DIQVHNPRFFKRVLQEGSLGLGESYMDGWWDCD-RLDEFFSRVLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 84 KGgsflTNNPFLKHLPKISHSEKESKKDVQS----------HYDIGNDFYRLWLDKTMTYSCAYFEhDDDTLEQAQLNKV 153
Cdd:PRK11705 82 AG----LDEKLPHHLKDTLRILRARLFNLQSkkrawivgkeHYDLGNDLFEAMLDPRMQYSCGYWK-DADTLEEAQEAKL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 154 RHILHKLNPVSGKRLLDIGSGWGTLIFMAAEEFGLHATGITLSKEQYDYTQQQIKerGLEdkVNVLLTDYREVKDQFDYV 233
Cdd:PRK11705 157 DLICRKLQLKPGMRVLDIGCGWGGLARYAAEHYGVSVVGVTISAEQQKLAQERCA--GLP--VEIRLQDYRDLNGQFDRI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 234 TSVGMFEHVGKENLGLYFQDVEKFLVPDGRALIHGITGQHEGAGVDPFLNKYIFPGGYIPNVAenltHIMNA--GLQ-LT 310
Cdd:PRK11705 233 VSVGMFEHVGPKNYRTYFEVVRRCLKPDGLFLLHTIGSNKTDTNVDPWINKYIFPNGCLPSVR----QIAQAseGLFvME 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490601742 311 DLEPLRRHYQKTLEIWYDNYVKVIDQAEAKYGKPFTRMWSLYLQGAAASFEAGNIDVMQYLLTK 374
Cdd:PRK11705 309 DWHNFGADYDRTLMAWHENFEAAWPELADNYSERFYRMWRYYLLSCAGAFRARDIQLWQVVFSP 372
|
|
| Cfa |
COG2230 |
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ... |
114-268 |
1.56e-78 |
|
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];
Pssm-ID: 441831 [Multi-domain] Cd Length: 158 Bit Score: 239.06 E-value: 1.56e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 114 SHYDIGNDFYRLWLDKTMTYSCAYFEHDDDTLEQAQLNKVRHILHKLNPVSGKRLLDIGSGWGTLIFMAAEEFGLHATGI 193
Cdd:COG2230 1 HHYDLGNDFYRLFLDPTMTYSCAYFEDPDDTLEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGV 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490601742 194 TLSKEQYDYTQQQIKERGLEDKVNVLLTDYREV--KDQFDYVTSVGMFEHVGKENLGLYFQDVEKFLVPDGRALIHG 268
Cdd:COG2230 81 TLSPEQLEYARERAAEAGLADRVEVRLADYRDLpaDGQFDAIVSIGMFEHVGPENYPAYFAKVARLLKPGGRLLLHT 157
|
|
| mycolic_MTase |
NF040660 |
cyclopropane mycolic acid synthase family methyltransferase; Members of this family include ... |
111-374 |
1.01e-66 |
|
cyclopropane mycolic acid synthase family methyltransferase; Members of this family include tailoring enzymes that make site-specific modifications to mycolic acid precursor molecules. These include Mycobacterium tuberculosis enzymes MmaA1-MmaA4, CmaA1-CmaA2, and PcaA. The family also includes UmaA, reported to be the lone member of this family not involved in mycolic acid biosynthesis. No members of this family are found in species that lack mycolic acids. This model excludes two more distantly related paralogs, Rv0447c (UfaA1 ) and Rv3720, that are also encoded in the Mycobacterium tuberculosis H37Rv genome.
Pssm-ID: 468626 Cd Length: 283 Bit Score: 213.09 E-value: 1.01e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 111 DVQSHYDIGNDFYRLWLDKTMTYSCAYFEHDDDTLEQAQLNKVRHILHKLNPVSGKRLLDIGSGWGTLIFMAAEEFGLHA 190
Cdd:NF040660 7 DVQAHYDLSDDFFALFLDPTQTYSCAYFERDDMTLEEAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAVEKYDVNV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 191 TGITLSKEQYDYTQQQIKERGLEDKVNVLLTDYREVKDQFDYVTSVGMFEHVGKENLGLYFQDVEKFLVPDGRALIHGIT 270
Cdd:NF040660 87 VGLTLSKNQAAHVQQVLDEIDTPRSRRVLLQGWEEFDEPVDRIVSIGAFEHFGHERYDDFFKRAYNILPADGRMLLHTIT 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 271 GQHEGAGVD-------------PFLNKYIFPGGYIPNVAENLTHIMNAGLQLTDLEPLRRHYQKTLEIWYDNYVKVIDQA 337
Cdd:NF040660 167 GLHRKEMHErglpltmelarfiKFIVTEIFPGGRLPSIEMVVEHAEKAGFTVTRVQSLQPHYARTLDLWADALQAHKDEA 246
|
250 260 270
....*....|....*....|....*....|....*..
gi 490601742 338 EAKYGKPFTRMWSLYLQGAAASFEAGNIDVMQYLLTK 374
Cdd:NF040660 247 IAIQSEEVYERYMKYLTGCAKLFRDGYIDVNQFTLAK 283
|
|
| AdoMet_MTases |
cd02440 |
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
167-267 |
7.18e-09 |
|
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 53.20 E-value: 7.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 167 RLLDIGSGWGTLIFMAAEEFGLHATGITLSKEQYDYTqQQIKERGLEDKVNVLLTDYREV----KDQFDYVTSVGMFEHV 242
Cdd:cd02440 1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELA-RKAAAALLADNVEVLKGDAEELppeaDESFDVIISDPPLHHL 79
|
90 100
....*....|....*....|....*
gi 490601742 243 gKENLGLYFQDVEKFLVPDGRALIH 267
Cdd:cd02440 80 -VEDLARFLEEARRLLKPGGVLVLT 103
|
|
| PKS_MT |
smart00828 |
Methyltransferase in polyketide synthase (PKS) enzymes; |
166-230 |
5.54e-06 |
|
Methyltransferase in polyketide synthase (PKS) enzymes;
Pssm-ID: 214839 [Multi-domain] Cd Length: 224 Bit Score: 47.03 E-value: 5.54e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490601742 166 KRLLDIGSGWGTLIFMAAEEFG-LHATGITLSKEQYDYTQQQIKERGLEDKVNVLltdYREV-KDQF 230
Cdd:smart00828 1 KRVLDFGCGYGSDLIDLAERHPhLQLHGYTISPEQAEVGRERIRALGLQGRIRIF---YRDSaKDPF 64
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CMAS |
pfam02353 |
Mycolic acid cyclopropane synthetase; This family consist of ... |
110-370 |
1.01e-114 |
|
Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.
Pssm-ID: 396777 [Multi-domain] Cd Length: 272 Bit Score: 335.45 E-value: 1.01e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 110 KDVQSHYDIGNDFYRLWLDKTMTYSCAYFEHDDDTLEQAQLNKVRHILHKLNPVSGKRLLDIGSGWGTLIFMAAEEFGLH 189
Cdd:pfam02353 7 ENIQAHYDLSNDFFALFLDPTMTYSCAYFERPDMTLEEAQQAKLDLILDKLGLKPGMTLLDIGCGWGGLMRRAAERYDVN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 190 ATGITLSKEQYDYTQQQIKERGLEDKVNVLLTDYREVKDQFDYVTSVGMFEHVGKENLGLYFQDVEKFLVPDGRALIHGI 269
Cdd:pfam02353 87 VVGLTLSKNQYKLARKRVAAEGLARKVEVLLQDYRDFDEPFDRIVSVGMFEHVGHENYDTFFKKLYNLLPPGGLMLLHTI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 270 TGQH-----EGAGVDPFLNKYIFPGGYIPNVAENLTHIMNAGLQLTDLEPLRRHYQKTLEIWYDNYVKVIDQAEAKYGKP 344
Cdd:pfam02353 167 TGLHpdetsERGLPLKFIDKYIFPGGELPSISMIVESSSEAGFTVEDVESLRPHYAKTLDLWAENLQANKDEAIALQSEE 246
|
250 260
....*....|....*....|....*.
gi 490601742 345 FTRMWSLYLQGAAASFEAGNIDVMQY 370
Cdd:pfam02353 247 FYRMWMLYLTGCAVAFRIGYIDVHQF 272
|
|
| cyclopro_CfaB |
NF040703 |
C17 cyclopropane fatty acid synthase CfaB; |
13-389 |
5.02e-109 |
|
C17 cyclopropane fatty acid synthase CfaB;
Pssm-ID: 468667 [Multi-domain] Cd Length: 393 Bit Score: 325.41 E-value: 5.02e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 13 HAFDIPVSVTYWNGKTENYGGDnPQVKIEIKKEIPLKEMTsQPTL-VLGEAYMNGDIDITGSIEELVASAYRKGGSFLTN 91
Cdd:NF040703 10 RNLQLPLRLRLWDGKQLDLGPS-PRVTLVVKDPSLLSQLT-HPSLdLLGSAYVEGRLDLEGPIMEVIRVGDELSQALLGD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 92 NPFLKHlPKISHSEKESKKDVQSHYDIGNDFYRLWLDKTMTYSCAYFEHDDDTLEQAQLNKVRHILHKLNPVSGKRLLDI 171
Cdd:NF040703 88 DDEAPP-ERTAHDKATDAAAISYHYDLSNDFYALWLDPDMVYSCAYFETGTEDLAQAQQAKLRHLCRKLRLQPGERLLDV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 172 GSGWGTLIFMAAEEFGLHATGITLSKEQYDYTQQQIKERGLEDKVNVLLTDYREV--KDQFDYVTSVGMFEHVGKENLGL 249
Cdd:NF040703 167 GCGWGGLARFAAREFGVEVFGITLSKEQLKLARERVAAEGLQDRVQLELLDYRDLpqDGRFDKVVSVGMFEHVGHANLPL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 250 YFQDVEKFLVPDGRALIHGITGQH-------EGAGvdPFLNKYIFPGGYIPNVAENLTHIMNAGLQLTDLEPLRRHYQKT 322
Cdd:NF040703 247 YCQRLFGAVRPGGLVMNHGITARHtdgrpvgRGAG--EFIGRYVFPHGELPHLATITASISEAGLEVVDVESLRLHYART 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490601742 323 LEIWYDNYVKVIDQAEAKYGKPFTRMWSLYLQGAAASFEAGNIDVMQYLLTK--APSGTGLPMTRQYVY 389
Cdd:NF040703 325 LEHWSARLEARLDEAARLVPERALRIWRLYLAGCAYGFARGWINLHQILAVKplADGSHELPWTRADLY 393
|
|
| PRK11705 |
PRK11705 |
cyclopropane fatty acyl phospholipid synthase; |
4-374 |
1.74e-88 |
|
cyclopropane fatty acyl phospholipid synthase;
Pssm-ID: 183282 Cd Length: 383 Bit Score: 272.49 E-value: 1.74e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 4 KTVYKELLSHAfDIPVsvtywngktenyGGDNPQvKIEIKKEIPLKEMTSQPTLVLGEAYMNGDIDITgSIEELVASAYR 83
Cdd:PRK11705 17 YRIANELLARA-GITI------------NGSRPW-DIQVHNPRFFKRVLQEGSLGLGESYMDGWWDCD-RLDEFFSRVLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 84 KGgsflTNNPFLKHLPKISHSEKESKKDVQS----------HYDIGNDFYRLWLDKTMTYSCAYFEhDDDTLEQAQLNKV 153
Cdd:PRK11705 82 AG----LDEKLPHHLKDTLRILRARLFNLQSkkrawivgkeHYDLGNDLFEAMLDPRMQYSCGYWK-DADTLEEAQEAKL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 154 RHILHKLNPVSGKRLLDIGSGWGTLIFMAAEEFGLHATGITLSKEQYDYTQQQIKerGLEdkVNVLLTDYREVKDQFDYV 233
Cdd:PRK11705 157 DLICRKLQLKPGMRVLDIGCGWGGLARYAAEHYGVSVVGVTISAEQQKLAQERCA--GLP--VEIRLQDYRDLNGQFDRI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 234 TSVGMFEHVGKENLGLYFQDVEKFLVPDGRALIHGITGQHEGAGVDPFLNKYIFPGGYIPNVAenltHIMNA--GLQ-LT 310
Cdd:PRK11705 233 VSVGMFEHVGPKNYRTYFEVVRRCLKPDGLFLLHTIGSNKTDTNVDPWINKYIFPNGCLPSVR----QIAQAseGLFvME 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490601742 311 DLEPLRRHYQKTLEIWYDNYVKVIDQAEAKYGKPFTRMWSLYLQGAAASFEAGNIDVMQYLLTK 374
Cdd:PRK11705 309 DWHNFGADYDRTLMAWHENFEAAWPELADNYSERFYRMWRYYLLSCAGAFRARDIQLWQVVFSP 372
|
|
| Cfa |
COG2230 |
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ... |
114-268 |
1.56e-78 |
|
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];
Pssm-ID: 441831 [Multi-domain] Cd Length: 158 Bit Score: 239.06 E-value: 1.56e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 114 SHYDIGNDFYRLWLDKTMTYSCAYFEHDDDTLEQAQLNKVRHILHKLNPVSGKRLLDIGSGWGTLIFMAAEEFGLHATGI 193
Cdd:COG2230 1 HHYDLGNDFYRLFLDPTMTYSCAYFEDPDDTLEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGV 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490601742 194 TLSKEQYDYTQQQIKERGLEDKVNVLLTDYREV--KDQFDYVTSVGMFEHVGKENLGLYFQDVEKFLVPDGRALIHG 268
Cdd:COG2230 81 TLSPEQLEYARERAAEAGLADRVEVRLADYRDLpaDGQFDAIVSIGMFEHVGPENYPAYFAKVARLLKPGGRLLLHT 157
|
|
| mycolic_MTase |
NF040660 |
cyclopropane mycolic acid synthase family methyltransferase; Members of this family include ... |
111-374 |
1.01e-66 |
|
cyclopropane mycolic acid synthase family methyltransferase; Members of this family include tailoring enzymes that make site-specific modifications to mycolic acid precursor molecules. These include Mycobacterium tuberculosis enzymes MmaA1-MmaA4, CmaA1-CmaA2, and PcaA. The family also includes UmaA, reported to be the lone member of this family not involved in mycolic acid biosynthesis. No members of this family are found in species that lack mycolic acids. This model excludes two more distantly related paralogs, Rv0447c (UfaA1 ) and Rv3720, that are also encoded in the Mycobacterium tuberculosis H37Rv genome.
Pssm-ID: 468626 Cd Length: 283 Bit Score: 213.09 E-value: 1.01e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 111 DVQSHYDIGNDFYRLWLDKTMTYSCAYFEHDDDTLEQAQLNKVRHILHKLNPVSGKRLLDIGSGWGTLIFMAAEEFGLHA 190
Cdd:NF040660 7 DVQAHYDLSDDFFALFLDPTQTYSCAYFERDDMTLEEAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAVEKYDVNV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 191 TGITLSKEQYDYTQQQIKERGLEDKVNVLLTDYREVKDQFDYVTSVGMFEHVGKENLGLYFQDVEKFLVPDGRALIHGIT 270
Cdd:NF040660 87 VGLTLSKNQAAHVQQVLDEIDTPRSRRVLLQGWEEFDEPVDRIVSIGAFEHFGHERYDDFFKRAYNILPADGRMLLHTIT 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 271 GQHEGAGVD-------------PFLNKYIFPGGYIPNVAENLTHIMNAGLQLTDLEPLRRHYQKTLEIWYDNYVKVIDQA 337
Cdd:NF040660 167 GLHRKEMHErglpltmelarfiKFIVTEIFPGGRLPSIEMVVEHAEKAGFTVTRVQSLQPHYARTLDLWADALQAHKDEA 246
|
250 260 270
....*....|....*....|....*....|....*..
gi 490601742 338 EAKYGKPFTRMWSLYLQGAAASFEAGNIDVMQYLLTK 374
Cdd:NF040660 247 IAIQSEEVYERYMKYLTGCAKLFRDGYIDVNQFTLAK 283
|
|
| Methyltransf_25 |
pfam13649 |
Methyltransferase domain; This family appears to be a methyltransferase domain. |
169-262 |
1.50e-15 |
|
Methyltransferase domain; This family appears to be a methyltransferase domain.
Pssm-ID: 463945 [Multi-domain] Cd Length: 96 Bit Score: 71.44 E-value: 1.50e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 169 LDIGSGWGTLIFMAAEEFGLHATGITLSKEQYDYTQQQIKERGLedKVNVLLTDYREV---KDQFDYVTSVGMFEHVGKE 245
Cdd:pfam13649 2 LDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLpfpDGSFDLVVSSGVLHHLPDP 79
|
90
....*....|....*..
gi 490601742 246 NLGLYFQDVEKFLVPDG 262
Cdd:pfam13649 80 DLEAALREIARVLKPGG 96
|
|
| UbiG |
COG2227 |
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ... |
152-266 |
3.43e-13 |
|
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis
Pssm-ID: 441829 [Multi-domain] Cd Length: 126 Bit Score: 65.81 E-value: 3.43e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 152 KVRHILHKLNPvSGKRLLDIGSGWGTLIFMAAEEfGLHATGITLSKEQYDYTqqqiKERGLEDKVNVLLTDYREVK---D 228
Cdd:COG2227 13 RLAALLARLLP-AGGRVLDVGCGTGRLALALARR-GADVTGVDISPEALEIA----RERAAELNVDFVQGDLEDLPledG 86
|
90 100 110
....*....|....*....|....*....|....*...
gi 490601742 229 QFDYVTSVGMFEHVgkENLGLYFQDVEKFLVPDGRALI 266
Cdd:COG2227 87 SFDLVICSEVLEHL--PDPAALLRELARLLKPGGLLLL 122
|
|
| UbiE |
COG2226 |
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ... |
154-266 |
5.61e-13 |
|
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis
Pssm-ID: 441828 [Multi-domain] Cd Length: 143 Bit Score: 65.79 E-value: 5.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 154 RHILHKLNPVSGKRLLDIGSGWGTLIFMAAEEfGLHATGITLSKEQYDYTQQQIKERGLedKVNVLLTDYREVK---DQF 230
Cdd:COG2226 12 EALLAALGLRPGARVLDLGCGTGRLALALAER-GARVTGVDISPEMLELARERAAEAGL--NVEFVVGDAEDLPfpdGSF 88
|
90 100 110
....*....|....*....|....*....|....*.
gi 490601742 231 DYVTSVGMFEHVgkENLGLYFQDVEKFLVPDGRALI 266
Cdd:COG2226 89 DLVISSFVLHHL--PDPERALAEIARVLKPGGRLVV 122
|
|
| SmtA |
COG0500 |
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ... |
165-268 |
1.06e-12 |
|
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];
Pssm-ID: 440266 [Multi-domain] Cd Length: 199 Bit Score: 66.48 E-value: 1.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 165 GKRLLDIGSGWGTLIFMAAEEFGLHATGITLSKEQYDYTQQQIKERGLeDKVNVLLTDYREVKD----QFDYVTSVGMFE 240
Cdd:COG0500 27 GGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGL-GNVEFLVADLAELDPlpaeSFDLVVAFGVLH 105
|
90 100
....*....|....*....|....*...
gi 490601742 241 HVGKENLGLYFQDVEKFLVPDGRALIHG 268
Cdd:COG0500 106 HLPPEEREALLRELARALKPGGVLLLSA 133
|
|
| AdoMet_MTases |
cd02440 |
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
167-267 |
7.18e-09 |
|
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 53.20 E-value: 7.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 167 RLLDIGSGWGTLIFMAAEEFGLHATGITLSKEQYDYTqQQIKERGLEDKVNVLLTDYREV----KDQFDYVTSVGMFEHV 242
Cdd:cd02440 1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELA-RKAAAALLADNVEVLKGDAEELppeaDESFDVIISDPPLHHL 79
|
90 100
....*....|....*....|....*
gi 490601742 243 gKENLGLYFQDVEKFLVPDGRALIH 267
Cdd:cd02440 80 -VEDLARFLEEARRLLKPGGVLVLT 103
|
|
| Methyltransf_11 |
pfam08241 |
Methyltransferase domain; Members of this family are SAM dependent methyltransferases. |
169-266 |
4.84e-08 |
|
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
Pssm-ID: 462406 [Multi-domain] Cd Length: 94 Bit Score: 50.36 E-value: 4.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 169 LDIGSGWGtLIFMAAEEFGLHATGITLSKEQYDYTQQQIKERGLEDKV-NVLLTDYREvkDQFDYVTSVGMFEHVgkENL 247
Cdd:pfam08241 1 LDVGCGTG-LLTELLARLGARVTGVDISPEMLELAREKAPREGLTFVVgDAEDLPFPD--NSFDLVLSSEVLHHV--EDP 75
|
90
....*....|....*....
gi 490601742 248 GLYFQDVEKFLVPDGRALI 266
Cdd:pfam08241 76 ERALREIARVLKPGGILII 94
|
|
| Methyltransf_12 |
pfam08242 |
Methyltransferase domain; Members of this family are SAM dependent methyltransferases. |
169-263 |
6.40e-08 |
|
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
Pssm-ID: 400515 [Multi-domain] Cd Length: 98 Bit Score: 50.06 E-value: 6.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 169 LDIGSGWGTLIFMAAEEF-GLHATGITLSKEQYDYTQQQIKERGLEDKVNVLLTDYREVKD---QFDYVTSVGMFEHVgk 244
Cdd:pfam08242 1 LEIGCGTGTLLRALLEALpGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELdpgSFDVVVASNVLHHL-- 78
|
90
....*....|....*....
gi 490601742 245 ENLGLYFQDVEKFLVPDGR 263
Cdd:pfam08242 79 ADPRAVLRNIRRLLKPGGV 97
|
|
| COG4976 |
COG4976 |
Predicted methyltransferase, contains TPR repeat [General function prediction only]; |
136-263 |
3.51e-07 |
|
Predicted methyltransferase, contains TPR repeat [General function prediction only];
Pssm-ID: 444001 [Multi-domain] Cd Length: 181 Bit Score: 50.00 E-value: 3.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 136 AYFEHD--DDTLEQAQLNKVRHILHKLNPVSGKRLLDIGSGWGTL-IFMAAeeFGLHATGITLSKEQYDytqqQIKERGL 212
Cdd:COG4976 16 DSYDAAlvEDLGYEAPALLAEELLARLPPGPFGRVLDLGCGTGLLgEALRP--RGYRLTGVDLSEEMLA----KAREKGV 89
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 490601742 213 EDKVNVL-LTDYREVKDQFDYVTSVGMFEHVGkeNLGLYFQDVEKFLVPDGR 263
Cdd:COG4976 90 YDRLLVAdLADLAEPDGRFDLIVAADVLTYLG--DLAAVFAGVARALKPGGL 139
|
|
| TrmN6 |
COG4123 |
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ... |
164-235 |
2.25e-06 |
|
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 443299 [Multi-domain] Cd Length: 238 Bit Score: 48.22 E-value: 2.25e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490601742 164 SGKRLLDIGSGWGTLIFMAAEEF-GLHATGITLSKEQYDYTQQQIKERGLEDKVNVLLTDYREVK-----DQFDYVTS 235
Cdd:COG4123 37 KGGRVLDLGTGTGVIALMLAQRSpGARITGVEIQPEAAELARRNVALNGLEDRITVIHGDLKEFAaelppGSFDLVVS 114
|
|
| PKS_MT |
smart00828 |
Methyltransferase in polyketide synthase (PKS) enzymes; |
166-230 |
5.54e-06 |
|
Methyltransferase in polyketide synthase (PKS) enzymes;
Pssm-ID: 214839 [Multi-domain] Cd Length: 224 Bit Score: 47.03 E-value: 5.54e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490601742 166 KRLLDIGSGWGTLIFMAAEEFG-LHATGITLSKEQYDYTQQQIKERGLEDKVNVLltdYREV-KDQF 230
Cdd:smart00828 1 KRVLDFGCGYGSDLIDLAERHPhLQLHGYTISPEQAEVGRERIRALGLQGRIRIF---YRDSaKDPF 64
|
|
| Methyltransf_31 |
pfam13847 |
Methyltransferase domain; This family appears to have methyltransferase activity. |
164-266 |
1.57e-05 |
|
Methyltransferase domain; This family appears to have methyltransferase activity.
Pssm-ID: 463998 [Multi-domain] Cd Length: 150 Bit Score: 44.72 E-value: 1.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 164 SGKRLLDIGSGWGTLIFMAAEEFGLHA--TGITLSKEQYDYTQQQIKERGLE----DKVNVLLTDYREVKDQFDYVTSVG 237
Cdd:pfam13847 3 KGMRVLDLGCGTGHLSFELAEELGPNAevVGIDISEEAIEKARENAQKLGFDnvefEQGDIEELPELLEDDKFDVVISNC 82
|
90 100
....*....|....*....|....*....
gi 490601742 238 MFEHVGkeNLGLYFQDVEKFLVPDGRALI 266
Cdd:pfam13847 83 VLNHIP--DPDKVLQEILRVLKPGGRLII 109
|
|
| Methyltransf_23 |
pfam13489 |
Methyltransferase domain; This family appears to be a methyltransferase domain. |
151-267 |
1.60e-05 |
|
Methyltransferase domain; This family appears to be a methyltransferase domain.
Pssm-ID: 404385 [Multi-domain] Cd Length: 162 Bit Score: 44.73 E-value: 1.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 151 NKVRHILHKL--NPVSGKRLLDIGSGWGTLIfMAAEEFGLHATGITLSKEQYDytqqqiKERGLEDKVNVLLTDYREVKD 228
Cdd:pfam13489 7 RLLADLLLRLlpKLPSPGRVLDFGCGTGIFL-RLLRAQGFSVTGVDPSPIAIE------RALLNVRFDQFDEQEAAVPAG 79
|
90 100 110
....*....|....*....|....*....|....*....
gi 490601742 229 QFDYVTSVGMFEHVgkENLGLYFQDVEKFLVPDGRALIH 267
Cdd:pfam13489 80 KFDVIVAREVLEHV--PDPPALLRQIAALLKPGGLLLLS 116
|
|
| COG4076 |
COG4076 |
Predicted RNA methylase [General function prediction only]; |
156-265 |
1.37e-04 |
|
Predicted RNA methylase [General function prediction only];
Pssm-ID: 443253 [Multi-domain] Cd Length: 230 Bit Score: 43.10 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 156 ILHKLNPvsGKRLLDIGSGWGTLIFMAAEEFGLHATGITLSKEQYDYTQQQIKERGLEDKVNVLLTDYREV--KDQFDYV 233
Cdd:COG4076 29 IERVVKP--GDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRITVINADATDLdlPEKADVI 106
|
90 100 110
....*....|....*....|....*....|....*..
gi 490601742 234 TS----VGMFEhvgkENLGLYFQDV-EKFLVPDGRAL 265
Cdd:COG4076 107 ISemldTALLD----EGQVPILNHArKRLLKPGGRII 139
|
|
| PLN02244 |
PLN02244 |
tocopherol O-methyltransferase |
166-266 |
3.50e-04 |
|
tocopherol O-methyltransferase
Pssm-ID: 215135 [Multi-domain] Cd Length: 340 Bit Score: 42.42 E-value: 3.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 166 KRLLDIGSGWGTLIFMAAEEFGLHATGITLSKEQYDYTQQQIKERGLEDKVNVLLTDYREV---KDQFDYVTSVGMFEHV 242
Cdd:PLN02244 120 KRIVDVGCGIGGSSRYLARKYGANVKGITLSPVQAARANALAAAQGLSDKVSFQVADALNQpfeDGQFDLVWSMESGEHM 199
|
90 100 110
....*....|....*....|....*....|.
gi 490601742 243 gkenlglyfQDVEKFL-------VPDGRALI 266
Cdd:PLN02244 200 ---------PDKRKFVqelarvaAPGGRIII 221
|
|
| Tam |
COG4106 |
Trans-aconitate methyltransferase [Energy production and conversion]; |
165-266 |
1.35e-03 |
|
Trans-aconitate methyltransferase [Energy production and conversion];
Pssm-ID: 443282 [Multi-domain] Cd Length: 100 Bit Score: 37.88 E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 165 GKRLLDIGSGWGTLIFMAAEEF-GLHATGITLSKEQYDYTQQQIkergleDKVNVLLTDYREVK--DQFDYVTSVGMFEH 241
Cdd:COG4106 2 PRRVLDLGCGTGRLTALLAERFpGARVTGVDLSPEMLARARARL------PNVRFVVADLRDLDppEPFDLVVSNAALHW 75
|
90 100
....*....|....*....|....*
gi 490601742 242 VgkENLGLYFQDVEKFLVPDGRALI 266
Cdd:COG4106 76 L--PDHAALLARLAAALAPGGVLAV 98
|
|
| PTZ00098 |
PTZ00098 |
phosphoethanolamine N-methyltransferase; Provisional |
159-266 |
5.13e-03 |
|
phosphoethanolamine N-methyltransferase; Provisional
Pssm-ID: 173391 [Multi-domain] Cd Length: 263 Bit Score: 38.41 E-value: 5.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490601742 159 KLNPVSgkRLLDIGSGWGTLIFMAAEEFGLHATGITLSKEQYDYTQQQIKERG-LEDKVNVLLT-DYREvkDQFDYVTSV 236
Cdd:PTZ00098 49 ELNENS--KVLDIGSGLGGGCKYINEKYGAHVHGVDICEKMVNIAKLRNSDKNkIEFEANDILKkDFPE--NTFDMIYSR 124
|
90 100 110
....*....|....*....|....*....|
gi 490601742 237 GMFEHVGKENLGLYFQDVEKFLVPDGRALI 266
Cdd:PTZ00098 125 DAILHLSYADKKKLFEKCYKWLKPNGILLI 154
|
|
| |
