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Conserved domains on  [gi|490869861|ref|WP_004731876|]
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MULTISPECIES: YfcZ/YiiS family protein [Vibrio]

Protein Classification

YfcZ/YiiS family protein( domain architecture ID 10514482)

YfcZ/YiiS family protein is a DUF406 domain-containing protein; similar to Vibrio parahaemolyticus protein VPA0419

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF406 pfam04175
Protein of unknown function (DUF406); Members of this family appear to be found only in gamma ...
 17-95 4.14e-24

Protein of unknown function (DUF406); Members of this family appear to be found only in gamma proteobacteria. The function of this protein family is undetermined. Solution of the structures of the two members of this family investigated bear some resemblance to that of the single domain enzyme pterin-4a-carbinolamine dehydratase, PDC. Although the residues of PCDs involved in binding of metabolite are not conserved in the two structures under study, they do correspond to a surface-region structurally aligned with residues that are highly conserved, eg Glu 89, suggesting that this region is also involved in binding of a ligand, thereby possibly constituting a catalytic site of a yet uncharacterized enzyme specific for gamma proteobacteria.


:

Pssm-ID: 427760  Cd Length: 81  Bit Score: 86.93  E-value: 4.14e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490869861  17 AGEIGFIIKEGDEVAEVTVYGNSKALIEAELAKYVELAKQVSSN--VEFEASEMTEDSTELHARFKFEVSAEKIIFELKT 94
Cdd:pfam04175  1 CVDVGTIIDNGDCVAEFSIVYASEAEAEAALAKLTEKAKAVESEpcEISSEITEVEDGVELDARFTFSCQAEKLIFELGL 80


                 .
gi 490869861  95 R 95
Cdd:pfam04175 81 R 81
 
Name Accession Description Interval E-value
DUF406 pfam04175
Protein of unknown function (DUF406); Members of this family appear to be found only in gamma ...
 17-95 4.14e-24

Protein of unknown function (DUF406); Members of this family appear to be found only in gamma proteobacteria. The function of this protein family is undetermined. Solution of the structures of the two members of this family investigated bear some resemblance to that of the single domain enzyme pterin-4a-carbinolamine dehydratase, PDC. Although the residues of PCDs involved in binding of metabolite are not conserved in the two structures under study, they do correspond to a surface-region structurally aligned with residues that are highly conserved, eg Glu 89, suggesting that this region is also involved in binding of a ligand, thereby possibly constituting a catalytic site of a yet uncharacterized enzyme specific for gamma proteobacteria.


Pssm-ID: 427760  Cd Length: 81  Bit Score: 86.93  E-value: 4.14e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490869861  17 AGEIGFIIKEGDEVAEVTVYGNSKALIEAELAKYVELAKQVSSN--VEFEASEMTEDSTELHARFKFEVSAEKIIFELKT 94
Cdd:pfam04175  1 CVDVGTIIDNGDCVAEFSIVYASEAEAEAALAKLTEKAKAVESEpcEISSEITEVEDGVELDARFTFSCQAEKLIFELGL 80


                 .
gi 490869861  95 R 95
Cdd:pfam04175 81 R 81
YfcZ COG3691
Uncharacterized conserved protein YfcZ, UPF0381/DUF406 family [Function unknown];
1-95 7.52e-12

Uncharacterized conserved protein YfcZ, UPF0381/DUF406 family [Function unknown];


Pssm-ID: 442906  Cd Length: 98  Bit Score: 56.13  E-value: 7.52e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490869861  1 MSQDIG--NNDVCEACGCAgEIGFIIKEGDEVAEVTVYGNSKALIEAELAKYVELAKQVSS---NVEFEASEMtEDSTEL 75
Cdd:COG3691   1 MSDAIKkcKAEETAACCCV-DVGTIIDNSDCTASFEAVYASEAEAEAALAALTEKARAVESepcEISSEITPV-EDGVLL 78

                        90       100
                ....*....|....*....|
gi 490869861 76 HARFKFEVSAEKIIFELKTR 95
Cdd:COG3691  79 KADFTFSCQAETLIFQLGLR 98
PRK09981 PRK09981
DUF406 domain-containing protein;
9-98 4.15e-08

DUF406 domain-containing protein;


Pssm-ID: 182180  Cd Length: 99  Bit Score: 46.82  E-value: 4.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490869861  9 DVCEACGCAGEIGFIIKEGDEVAEVTVYGNSKALIEAELAKYVELAKQVSS-----NVEFEASEMtEDSTELHARFKFEV 83
Cdd:PRK09981  6 DKCSTKGCAIDIGTVIDNDNCTSKFSRFFATREEAESFMTKLKELAAAASSadegaSVAYKIKDL-EGQVELDAAFTFSC 84

                        90
                ....*....|....*
gi 490869861 84 SAEKIIFELKTRSLA 98
Cdd:PRK09981 85 QAEMIIFELSLRSLA 99
 
Name Accession Description Interval E-value
DUF406 pfam04175
Protein of unknown function (DUF406); Members of this family appear to be found only in gamma ...
 17-95 4.14e-24

Protein of unknown function (DUF406); Members of this family appear to be found only in gamma proteobacteria. The function of this protein family is undetermined. Solution of the structures of the two members of this family investigated bear some resemblance to that of the single domain enzyme pterin-4a-carbinolamine dehydratase, PDC. Although the residues of PCDs involved in binding of metabolite are not conserved in the two structures under study, they do correspond to a surface-region structurally aligned with residues that are highly conserved, eg Glu 89, suggesting that this region is also involved in binding of a ligand, thereby possibly constituting a catalytic site of a yet uncharacterized enzyme specific for gamma proteobacteria.


Pssm-ID: 427760  Cd Length: 81  Bit Score: 86.93  E-value: 4.14e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490869861  17 AGEIGFIIKEGDEVAEVTVYGNSKALIEAELAKYVELAKQVSSN--VEFEASEMTEDSTELHARFKFEVSAEKIIFELKT 94
Cdd:pfam04175  1 CVDVGTIIDNGDCVAEFSIVYASEAEAEAALAKLTEKAKAVESEpcEISSEITEVEDGVELDARFTFSCQAEKLIFELGL 80


                 .
gi 490869861  95 R 95
Cdd:pfam04175 81 R 81
YfcZ COG3691
Uncharacterized conserved protein YfcZ, UPF0381/DUF406 family [Function unknown];
1-95 7.52e-12

Uncharacterized conserved protein YfcZ, UPF0381/DUF406 family [Function unknown];


Pssm-ID: 442906  Cd Length: 98  Bit Score: 56.13  E-value: 7.52e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490869861  1 MSQDIG--NNDVCEACGCAgEIGFIIKEGDEVAEVTVYGNSKALIEAELAKYVELAKQVSS---NVEFEASEMtEDSTEL 75
Cdd:COG3691   1 MSDAIKkcKAEETAACCCV-DVGTIIDNSDCTASFEAVYASEAEAEAALAALTEKARAVESepcEISSEITPV-EDGVLL 78

                        90       100
                ....*....|....*....|
gi 490869861 76 HARFKFEVSAEKIIFELKTR 95
Cdd:COG3691  79 KADFTFSCQAETLIFQLGLR 98
PRK09981 PRK09981
DUF406 domain-containing protein;
9-98 4.15e-08

DUF406 domain-containing protein;


Pssm-ID: 182180  Cd Length: 99  Bit Score: 46.82  E-value: 4.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490869861  9 DVCEACGCAGEIGFIIKEGDEVAEVTVYGNSKALIEAELAKYVELAKQVSS-----NVEFEASEMtEDSTELHARFKFEV 83
Cdd:PRK09981  6 DKCSTKGCAIDIGTVIDNDNCTSKFSRFFATREEAESFMTKLKELAAAASSadegaSVAYKIKDL-EGQVELDAAFTFSC 84

                        90
                ....*....|....*
gi 490869861 84 SAEKIIFELKTRSLA 98
Cdd:PRK09981 85 QAEMIIFELSLRSLA 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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