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Conserved domains on  [gi|490873565|ref|WP_004735566|]
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MULTISPECIES: Sec-independent protein translocase protein TatB [Vibrio]

Protein Classification

Sec-independent protein translocase subunit TatB( domain architecture ID 10019022)

Sec-independent protein translocase subunit TatB, together with TatC, forms the binding site that directly interacts with Tat signal peptides within the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tatB TIGR01410
twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a ...
 2-81 1.39e-34

twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a Sec-independent system for transporting folded proteins, often with a bound redox cofactor, across the bacterial inner membrane. TatC is the multiple membrane spanning component. TatB, like the related TatA/E proteins, appears to span the membrane one time. The tat system recognizes proteins with an elongated signal sequence containing a conserved R-R in a motif approximated by RRxFLK N-terminal to the transmembrane helix. TIGRFAMs model TIGR01409 describes this twin-Arg signal sequence. A similar system, termed Delta-pH-dependent transport, operates on chloroplast-encoded proteins. [Protein fate, Protein and peptide secretion and trafficking]


:

Pssm-ID: 130477 [Multi-domain]  Cd Length: 80  Bit Score: 115.10  E-value: 1.39e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873565    2 FDIGFWELVLISVVGLVVLGPERLPVAIRSISKFVGQAKSMANSVKDELSHELKVQELQENLRKAEKMGMEDLSPDLKAS 81
Cdd:TIGR01410   1 FDIGFSELLLIAVVALVVLGPERLPVAIRTVGGFVRALRGMASDVKNELDEELKLQELDDQLKKAQQARFLNLTAELKDS 80
 
Name Accession Description Interval E-value
tatB TIGR01410
twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a ...
 2-81 1.39e-34

twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a Sec-independent system for transporting folded proteins, often with a bound redox cofactor, across the bacterial inner membrane. TatC is the multiple membrane spanning component. TatB, like the related TatA/E proteins, appears to span the membrane one time. The tat system recognizes proteins with an elongated signal sequence containing a conserved R-R in a motif approximated by RRxFLK N-terminal to the transmembrane helix. TIGRFAMs model TIGR01409 describes this twin-Arg signal sequence. A similar system, termed Delta-pH-dependent transport, operates on chloroplast-encoded proteins. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 130477 [Multi-domain]  Cd Length: 80  Bit Score: 115.10  E-value: 1.39e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873565    2 FDIGFWELVLISVVGLVVLGPERLPVAIRSISKFVGQAKSMANSVKDELSHELKVQELQENLRKAEKMGMEDLSPDLKAS 81
Cdd:TIGR01410   1 FDIGFSELLLIAVVALVVLGPERLPVAIRTVGGFVRALRGMASDVKNELDEELKLQELDDQLKKAQQARFLNLTAELKDS 80
TatA COG1826
Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, ...
 1-68 1.80e-21

Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441431 [Multi-domain]  Cd Length: 72  Bit Score: 81.52  E-value: 1.80e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490873565   1 MFDIGFWELVLISVVGLVVLGPERLPVAIRSISKFVGQAKSMANSVKDELSHELKVQELQENLRKAEK 68
Cdd:COG1826    1 MFGIGFWELLIILVVALLVFGPKKLPELARSLGKAIREFKKAANEVKEELDEELKEEELRKSEKEAEE 68
PRK04654 PRK04654
sec-independent translocase; Provisional
 1-94 1.19e-17

sec-independent translocase; Provisional


Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 75.23  E-value: 1.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873565   1 MFDIGFWELVLISVVGLVVLGPERLPVAIRSISKFVGQAKSMANSVKDELSHELKVQELQENLrkaekmgmEDLSPDLKA 80
Cdd:PRK04654   1 MFDIGVGELTLIAVVALVVLGPERLPKAARFAGLWVRRARMQWDSVKQELERELEAEELKRSL--------QDVQASLRE 72

                         90
                 ....*....|....
gi 490873565  81 SVDELKQAAAQVQR 94
Cdd:PRK04654  73 AEDQLRNTQQQVEQ 86
TatA_B_E pfam02416
mttA/Hcf106 family; Members of this protein family are involved in a sec independent ...
 4-53 8.49e-05

mttA/Hcf106 family; Members of this protein family are involved in a sec independent translocation mechanism. This pathway has been called the DeltapH pathway in chloroplasts. Members of this family in E.coli are involved in export of redox proteins with a "twin arginine" leader motif.


Pssm-ID: 426762  Cd Length: 53  Bit Score: 38.06  E-value: 8.49e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 490873565    4 IGFWELVLISVVGLVVLGPERLPVAIRSISKFVGQAKSMANSVKDELSHE 53
Cdd:pfam02416   1 LGIPELLIILVVALLLFGPKKLPELGRALGKTLREFKKATKELEEEDEKE 50
 
Name Accession Description Interval E-value
tatB TIGR01410
twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a ...
 2-81 1.39e-34

twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a Sec-independent system for transporting folded proteins, often with a bound redox cofactor, across the bacterial inner membrane. TatC is the multiple membrane spanning component. TatB, like the related TatA/E proteins, appears to span the membrane one time. The tat system recognizes proteins with an elongated signal sequence containing a conserved R-R in a motif approximated by RRxFLK N-terminal to the transmembrane helix. TIGRFAMs model TIGR01409 describes this twin-Arg signal sequence. A similar system, termed Delta-pH-dependent transport, operates on chloroplast-encoded proteins. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 130477 [Multi-domain]  Cd Length: 80  Bit Score: 115.10  E-value: 1.39e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873565    2 FDIGFWELVLISVVGLVVLGPERLPVAIRSISKFVGQAKSMANSVKDELSHELKVQELQENLRKAEKMGMEDLSPDLKAS 81
Cdd:TIGR01410   1 FDIGFSELLLIAVVALVVLGPERLPVAIRTVGGFVRALRGMASDVKNELDEELKLQELDDQLKKAQQARFLNLTAELKDS 80
TatA COG1826
Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, ...
 1-68 1.80e-21

Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441431 [Multi-domain]  Cd Length: 72  Bit Score: 81.52  E-value: 1.80e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490873565   1 MFDIGFWELVLISVVGLVVLGPERLPVAIRSISKFVGQAKSMANSVKDELSHELKVQELQENLRKAEK 68
Cdd:COG1826    1 MFGIGFWELLIILVVALLVFGPKKLPELARSLGKAIREFKKAANEVKEELDEELKEEELRKSEKEAEE 68
PRK04654 PRK04654
sec-independent translocase; Provisional
 1-94 1.19e-17

sec-independent translocase; Provisional


Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 75.23  E-value: 1.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873565   1 MFDIGFWELVLISVVGLVVLGPERLPVAIRSISKFVGQAKSMANSVKDELSHELKVQELQENLrkaekmgmEDLSPDLKA 80
Cdd:PRK04654   1 MFDIGVGELTLIAVVALVVLGPERLPKAARFAGLWVRRARMQWDSVKQELERELEAEELKRSL--------QDVQASLRE 72

                         90
                 ....*....|....
gi 490873565  81 SVDELKQAAAQVQR 94
Cdd:PRK04654  73 AEDQLRNTQQQVEQ 86
PRK01371 PRK01371
Sec-independent protein translocase protein TatB;
1-54 1.47e-11

Sec-independent protein translocase protein TatB;


Pssm-ID: 179287 [Multi-domain]  Cd Length: 137  Bit Score: 57.80  E-value: 1.47e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 490873565   1 MFDIGFWELVLISVVGLVVLGPERLPVAIRSISKFVGQAKSMANSVKDELSHEL 54
Cdd:PRK01371   1 MFGIGPGELVVLVVLAVLVFGPDKLPKAARDAGRTLRQLREMANNARNDLRSEL 54
tatA PRK14858
twin arginine translocase protein A; Provisional
 1-106 3.10e-09

twin arginine translocase protein A; Provisional


Pssm-ID: 184860  Cd Length: 108  Bit Score: 51.02  E-value: 3.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490873565   1 MFDIGFWELVLISVVGLVVLGPERLPVAIRSISKFVGQAKSMANSVKDELSHELKVQELQENLRKAEKMGMEDLSPDLKA 80
Cdd:PRK14858   1 MFGIGMPELIVILVIALIVIGPQKLPDLARSLGRGLAEFKKATDDFKQSMQEESRTAEEKEKAEKLAETKKEAEAPEAKA 80

                         90       100
                 ....*....|....*....|....*...
gi 490873565  81 SVDELKQAAAQVQRPY--AKPESDKPSE 106
Cdd:PRK14858  81 EEDQAPKPKGAGEPPAtvASKAGDGAKA 108
tatB PRK00182
Sec-independent protein translocase subunit TatB;
1-65 1.54e-06

Sec-independent protein translocase subunit TatB;


Pssm-ID: 234681  Cd Length: 160  Bit Score: 44.82  E-value: 1.54e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490873565   1 MF-DIGFWELVLISVVGLVVLGPERLPVAIRSISKFVGQAKSMANSVKDELSHEL--KVQELQENLRK 65
Cdd:PRK00182   1 MFsSVGWGEILLLLIVGLIVIGPERLPRLIEDVRAALLAARTAINNAKQQLDGDFgeEFDEFRKPLNQ 68
tatA PRK14861
twin arginine translocase protein A; Provisional
 1-58 5.01e-06

twin arginine translocase protein A; Provisional


Pssm-ID: 237837  Cd Length: 61  Bit Score: 41.49  E-value: 5.01e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490873565   1 MFDIGFWELVLISVVGLVVLGPERLPVAIRSISKFVGQAKSMANSVKDELSHELKVQE 58
Cdd:PRK14861   2 FSNIGFPGLILILVVALIIFGPKKLPELGKALGKTLREFKKATKELTDDDFQEKKKKE 59
TatA_B_E pfam02416
mttA/Hcf106 family; Members of this protein family are involved in a sec independent ...
 4-53 8.49e-05

mttA/Hcf106 family; Members of this protein family are involved in a sec independent translocation mechanism. This pathway has been called the DeltapH pathway in chloroplasts. Members of this family in E.coli are involved in export of redox proteins with a "twin arginine" leader motif.


Pssm-ID: 426762  Cd Length: 53  Bit Score: 38.06  E-value: 8.49e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 490873565    4 IGFWELVLISVVGLVVLGPERLPVAIRSISKFVGQAKSMANSVKDELSHE 53
Cdd:pfam02416   1 LGIPELLIILVVALLLFGPKKLPELGRALGKTLREFKKATKELEEEDEKE 50
tatAE TIGR01411
twin arginine-targeting protein translocase, TatA/E family; This model distinguishes TatA/E ...
 4-49 5.40e-04

twin arginine-targeting protein translocase, TatA/E family; This model distinguishes TatA/E from the related TatB, but does not distinguish TatA from TatE. The Tat (twin-arginine translocation) system is a Sec-independent exporter for folded proteins, often with a redox cofactor already bound, across the bacterial inner membrane. Functionally equivalent systems are found in the chloroplast and some in archaeal species. The signal peptide recognized by the Tat system is modeled by TIGR01409. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273605 [Multi-domain]  Cd Length: 47  Bit Score: 35.66  E-value: 5.40e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 490873565    4 IGFWELVLISVVGLVVLGPERLPVAIRSISKFVGQAKSMANSVKDE 49
Cdd:TIGR01411   2 LSPPEWLIILVVILLLFGAKKLPELGRDLGKAIKEFKKALKEEEDE 47
tatA PRK00575
Sec-independent protein translocase subunit TatA;
1-49 3.06e-03

Sec-independent protein translocase subunit TatA;


Pssm-ID: 234797 [Multi-domain]  Cd Length: 92  Bit Score: 34.72  E-value: 3.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 490873565   1 MFDIGFWELVLISVVGLVVLGPERLPVAIRSISK----FVGQAKSMANSVKDE 49
Cdd:PRK00575   1 MGSLSPWHWAILAVVVILLFGAKKLPDAARSLGKslriFKSEVKEMQSDNKAE 53
tatA PRK14857
TatA/E family twin arginine-targeting protein translocase;
2-77 3.09e-03

TatA/E family twin arginine-targeting protein translocase;


Pssm-ID: 184859  Cd Length: 90  Bit Score: 34.70  E-value: 3.09e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490873565   2 FDIGFWELVLISVVGLVVLGPERLPVAIRSISKFVGQAKSMANSVKDELSHELKvQELQENLRKAEKMGMEDLSPD 77
Cdd:PRK14857   4 FGIGLPEMAVILVIALLVFGPKKLPEIGRSLGKTLKGFQEASKEFENEIKREMA-EPEQEVKAPAELESNQTNEAN 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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