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Conserved domains on  [gi|490947524|ref|WP_004809351|]
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PadR family transcriptional regulator [Cutibacterium avidum]

Protein Classification

PadR family transcriptional regulator( domain architecture ID 11447737)

PadR family transcriptional regulator similar to the phenolic acid decarboxylation repressor, which is a transcription factor that represses genes associated with the phenolic acid stress response in gram-positive bacteria

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  10679470|10908318|10473770|15808743|8831795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
3-101 2.68e-33

DNA-binding transcriptional regulator, PadR family [Transcription];


:

Pssm-ID: 441301  Cd Length: 102  Bit Score: 111.57  E-value: 2.68e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490947524   3 ERQLRKGALELVVLGLLASKPSYGGELVDRLENETD--LGVSQGTLYPLLNRLRRGDLVSTEWQESPSGPPRKIYRLTAA 80
Cdd:COG1695    2 KRQLRKGTLELLILALLAEGPMYGYEIIKELEERSGgfWKVSEGTLYPALKRLEKEGLVESEWEESEGGPRRKYYRLTEA 81

                         90       100
                 ....*....|....*....|.
gi 490947524  81 GRGHLTELIDEWSRIAAAVDR 101
Cdd:COG1695   82 GREELAEWLEEWEKLAEALEA 102
 
Name Accession Description Interval E-value
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
3-101 2.68e-33

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 111.57  E-value: 2.68e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490947524   3 ERQLRKGALELVVLGLLASKPSYGGELVDRLENETD--LGVSQGTLYPLLNRLRRGDLVSTEWQESPSGPPRKIYRLTAA 80
Cdd:COG1695    2 KRQLRKGTLELLILALLAEGPMYGYEIIKELEERSGgfWKVSEGTLYPALKRLEKEGLVESEWEESEGGPRRKYYRLTEA 81

                         90       100
                 ....*....|....*....|.
gi 490947524  81 GRGHLTELIDEWSRIAAAVDR 101
Cdd:COG1695   82 GREELAEWLEEWEKLAEALEA 102
padR_acidobact TIGR03433
transcriptional regulator, Acidobacterial, PadR-family; Members of this protein family are ...
 8-104 2.08e-21

transcriptional regulator, Acidobacterial, PadR-family; Members of this protein family are putative transcriptional regulators of the PadR family, as found in species of the Acidobacteria. This family of proteins has expanded greatly in this lineage, and where it regularly is found in the vicinity of a putative transporter protein [Regulatory functions, DNA interactions]


Pssm-ID: 163261  Cd Length: 100  Bit Score: 81.45  E-value: 2.08e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490947524    8 KGALELVVLGLLASKPSYGGELVDRLENETD--LGVSQGTLYPLLNRLRRGDLVSTEWQESPSGPPRKIYRLTAAGRGHL 85
Cdd:TIGR03433   2 QGTLDLLILKTLSLGPLHGYGIAQRIQQISEdvLQVEEGSLYPALHRLERRGWIAAEWGESENNRRAKFYRLTAAGRKQL 81

                          90
                  ....*....|....*....
gi 490947524   86 TELIDEWSRIAAAVDRVTN 104
Cdd:TIGR03433  82 AAETESWARLSAAIARVLG 100
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 15-82 7.40e-20

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


Pssm-ID: 397561  Cd Length: 74  Bit Score: 76.52  E-value: 7.40e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490947524   15 VLGLLASKPSYGGELVDRLENETD--LGVSQGTLYPLLNRLRRGDLVSTEWQESPSGPPRKIYRLTAAGR 82
Cdd:pfam03551   1 VLAVLGEQPRYGYEIIKELEELSGgfWRPSEGTLYPILKRLEKEGLVESEWVDSGGGPPRKYYRLTDAGR 70
lstR PRK09416
PadR family transcriptional regulator;
26-88 2.98e-05

PadR family transcriptional regulator;


Pssm-ID: 181836  Cd Length: 135  Bit Score: 40.54  E-value: 2.98e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490947524  26 GGELVDRLE--NETDLGVSQGTLYPLLNRLRRGDLVSTEWQESPSgpprKIYRLTAAGRGHLTEL 88
Cdd:PRK09416  58 GYELLQLLRqrGILTFEGNEGSLYTLLHRLEQNRFIQSSWDHEGA----KYYQLTDKGNKMLRKA 118
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 13-82 1.09e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.97  E-value: 1.09e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490947524  13 LVVLGLLASKPSYGGELVDRLenetdlGVSQGTLYPLLNRLRRGDLVSTEWQespsgPPRKIYRLTAAGR 82
Cdd:cd00090   10 LRILRLLLEGPLTVSELAERL------GLSQSTVSRHLKKLEEAGLVESRRE-----GRRVYYSLTDAER 68
 
Name Accession Description Interval E-value
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
3-101 2.68e-33

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 111.57  E-value: 2.68e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490947524   3 ERQLRKGALELVVLGLLASKPSYGGELVDRLENETD--LGVSQGTLYPLLNRLRRGDLVSTEWQESPSGPPRKIYRLTAA 80
Cdd:COG1695    2 KRQLRKGTLELLILALLAEGPMYGYEIIKELEERSGgfWKVSEGTLYPALKRLEKEGLVESEWEESEGGPRRKYYRLTEA 81

                         90       100
                 ....*....|....*....|.
gi 490947524  81 GRGHLTELIDEWSRIAAAVDR 101
Cdd:COG1695   82 GREELAEWLEEWEKLAEALEA 102
padR_acidobact TIGR03433
transcriptional regulator, Acidobacterial, PadR-family; Members of this protein family are ...
 8-104 2.08e-21

transcriptional regulator, Acidobacterial, PadR-family; Members of this protein family are putative transcriptional regulators of the PadR family, as found in species of the Acidobacteria. This family of proteins has expanded greatly in this lineage, and where it regularly is found in the vicinity of a putative transporter protein [Regulatory functions, DNA interactions]


Pssm-ID: 163261  Cd Length: 100  Bit Score: 81.45  E-value: 2.08e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490947524    8 KGALELVVLGLLASKPSYGGELVDRLENETD--LGVSQGTLYPLLNRLRRGDLVSTEWQESPSGPPRKIYRLTAAGRGHL 85
Cdd:TIGR03433   2 QGTLDLLILKTLSLGPLHGYGIAQRIQQISEdvLQVEEGSLYPALHRLERRGWIAAEWGESENNRRAKFYRLTAAGRKQL 81

                          90
                  ....*....|....*....
gi 490947524   86 TELIDEWSRIAAAVDRVTN 104
Cdd:TIGR03433  82 AAETESWARLSAAIARVLG 100
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 15-82 7.40e-20

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


Pssm-ID: 397561  Cd Length: 74  Bit Score: 76.52  E-value: 7.40e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490947524   15 VLGLLASKPSYGGELVDRLENETD--LGVSQGTLYPLLNRLRRGDLVSTEWQESPSGPPRKIYRLTAAGR 82
Cdd:pfam03551   1 VLAVLGEQPRYGYEIIKELEELSGgfWRPSEGTLYPILKRLEKEGLVESEWVDSGGGPPRKYYRLTDAGR 70
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
15-112 5.29e-07

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 44.64  E-value: 5.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490947524  15 VLGLLASKPSYGGELVDRLenetdlGVSQGTLYPLLNRLRRGDLVSTEWQESPSGPPRKIYRLTAAgRGHLTELIDEWSR 94
Cdd:COG1777   22 ILALLSEEPAYVSELAREL------GVSRQAVYKHLRKLEEAGLVESYREGREDGRARKYYRLSAF-RLEVTLTPDLFAR 94

                         90
                 ....*....|....*...
gi 490947524  95 IAAAVDRVTNDNHNTSGK 112
Cdd:COG1777   95 LARELEAYRRELSGRLAR 112
lstR PRK09416
PadR family transcriptional regulator;
26-88 2.98e-05

PadR family transcriptional regulator;


Pssm-ID: 181836  Cd Length: 135  Bit Score: 40.54  E-value: 2.98e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490947524  26 GGELVDRLE--NETDLGVSQGTLYPLLNRLRRGDLVSTEWQESPSgpprKIYRLTAAGRGHLTEL 88
Cdd:PRK09416  58 GYELLQLLRqrGILTFEGNEGSLYTLLHRLEQNRFIQSSWDHEGA----KYYQLTDKGNKMLRKA 118
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
15-82 1.06e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 36.80  E-value: 1.06e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490947524  15 VLGLLASKPSYGGELVDRLenetdlGVSQGTLYPLLNRLRRGDLVSTEwqespsgppRKIYRLTAAGR 82
Cdd:COG4742   21 ILLLLAEGPKTRSELAESL------DVSRSTILRQLKELEERGLIERD---------DGEYELTTLGR 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 13-82 1.09e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.97  E-value: 1.09e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490947524  13 LVVLGLLASKPSYGGELVDRLenetdlGVSQGTLYPLLNRLRRGDLVSTEWQespsgPPRKIYRLTAAGR 82
Cdd:cd00090   10 LRILRLLLEGPLTVSELAERL------GLSQSTVSRHLKKLEEAGLVESRRE-----GRRVYYSLTDAER 68
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-99 6.44e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 34.18  E-value: 6.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490947524   1 MAERQLRKGAL---ELVVLGLLASKPS-YGGELVDRLenetdlGVSQGTLYPLLNRLRRGDLVstEWQESPSGPPRKIYR 76
Cdd:COG1846   26 ALDRALAELGLtpaQFRVLAALAEAGGlTQSELAERL------GLTKSTVSRLLDRLEEKGLV--EREPDPEDRRAVLVR 97

                         90       100
                 ....*....|....*....|...
gi 490947524  77 LTAAGRGHLTELIDEWSRIAAAV 99
Cdd:COG1846   98 LTEKGRALLEEARPALEALLAEL 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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