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Conserved domains on  [gi|491102533|ref|WP_004964133|]
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MULTISPECIES: Lrp/AsnC ligand binding domain-containing protein [Haloarcula]

Protein Classification

Lrp/AsnC ligand binding domain-containing protein( domain architecture ID 10470669)

Lrp/AsnC ligand binding domain-containing protein similar to Thermus thermophilus SraA; the Lrp/AsnC ligand binding domain is usually found at C-terminal end of L-leucine-responsive regulatory protein (Lrp/AsnC) family

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Lrp super family cl34293
DNA-binding transcriptional regulator, Lrp family [Transcription];
2-75 3.57e-10

DNA-binding transcriptional regulator, Lrp family [Transcription];


The actual alignment was detected with superfamily member COG1522:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 52.09  E-value: 3.57e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491102533   2 VSAFIMIKTAAGKSEELLAAVRDAEGITEAHIVAGQYDIIGEATGTEVYDIMQSVSGHVRDLDGVADTRTYICL 75
Cdd:COG1522   65 VTAFVEVKVPPHRLDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
2-75 3.57e-10

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 52.09  E-value: 3.57e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491102533   2 VSAFIMIKTAAGKSEELLAAVRDAEGITEAHIVAGQYDIIGEATGTEVYDIMQSVSGHVRDLDGVADTRTYICL 75
Cdd:COG1522   65 VTAFVEVKVPPHRLDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
6-76 1.85e-07

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 43.67  E-value: 1.85e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491102533   6 IMIKTAAGKS-EELLAAVRDAEGITEAHIVAGQYDIIGEATGTEVYDIMQSVSGHVRDLDGVADTRTYICLE 76
Cdd:pfam01037  1 VEVKLEPGHAlEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLS 72
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
2-41 1.42e-03

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 34.03  E-value: 1.42e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 491102533     2 VSAFIMIKT-AAGKSEELLAAVRDAEGITEAHIVAGQYDII 41
Cdd:smart00344  63 VTAFVGVTLeNPDKLEEFLEKLEKLPEVEEVYLVTGDYDYL 103
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
7-76 3.24e-03

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 33.97  E-value: 3.24e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491102533   7 MIKTAAGKSEELLAAVRDAEGITEAHIVAGQYDIIGEATGTEVYDIMQSVSGHVRDLDGVADTRTYICLE 76
Cdd:PRK11169  82 LNRGAPDVFEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVME 151
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
2-75 3.57e-10

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 52.09  E-value: 3.57e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491102533   2 VSAFIMIKTAAGKSEELLAAVRDAEGITEAHIVAGQYDIIGEATGTEVYDIMQSVSGHVRDLDGVADTRTYICL 75
Cdd:COG1522   65 VTAFVEVKVPPHRLDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
6-76 1.85e-07

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 43.67  E-value: 1.85e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491102533   6 IMIKTAAGKS-EELLAAVRDAEGITEAHIVAGQYDIIGEATGTEVYDIMQSVSGHVRDLDGVADTRTYICLE 76
Cdd:pfam01037  1 VEVKLEPGHAlEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLS 72
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
2-41 1.42e-03

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 34.03  E-value: 1.42e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 491102533     2 VSAFIMIKT-AAGKSEELLAAVRDAEGITEAHIVAGQYDII 41
Cdd:smart00344  63 VTAFVGVTLeNPDKLEEFLEKLEKLPEVEEVYLVTGDYDYL 103
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
7-76 3.24e-03

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 33.97  E-value: 3.24e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491102533   7 MIKTAAGKSEELLAAVRDAEGITEAHIVAGQYDIIGEATGTEVYDIMQSVSGHVRDLDGVADTRTYICLE 76
Cdd:PRK11169  82 LNRGAPDVFEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVME 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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