|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
24-399 |
1.02e-110 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 329.53 E-value: 1.02e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMG 103
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 104 CAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGEMDWRWPFWISLA 183
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 184 ALPVGLLALSVPLERPHTGMDWK-QYARDSRSIIFHSAAIGLFGLTFLCFCILYGPTITYFPLLADLLYKATPSHIGAVF 262
Cdd:cd17474 161 LIPVAFLAILFLLPEPKEKAKSSsATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 263 TVASLGTAAIAMNLA-WLGRKYSHRRLMLSATCCYVVAQTLMLVLPdavsSLWWLTLPIFIGGVAQGLTFPLLNARMTTL 341
Cdd:cd17474 241 AGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVP----SLALLLIAIVLFGLGLGLNLPLLTTLVTEL 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 491167012 342 APTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGIGVALVIGALVWRV 399
Cdd:cd17474 317 APEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
24-397 |
5.93e-56 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 188.55 E-value: 5.93e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVALMGVMGVSITLPILPKLGAVFHQDAAG-VALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGM 102
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELlVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 103 GCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGEMDWRWPFWISL 182
Cdd:cd17473 81 AGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 183 AALPVGLLALSVPLERPHTGMDWKQYARDSRSIIFHSAAIGLFGLTFLCFCILYGpTITYFPLLADLLYKATPSHIGAVF 262
Cdd:cd17473 161 LALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYV-IPIQLPFLLQERGGGSAALIGLAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 263 TVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVlpdaVSSLWWLTLPIFIGGVAQGLTFPLLNARMTTLA 342
Cdd:cd17473 240 AIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLAL----ASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLV 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 491167012 343 PTRNRAIVMAMNGTVLRLSQSLSPLFFG-IGWSYIGWRGPYAMGIGVALVIGALVW 397
Cdd:cd17473 316 PPELRGRAMGIVTSAFFLGQFLSPLVLGpLVNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
27-398 |
2.21e-47 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 165.83 E-value: 2.21e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 27 VLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAF 106
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 107 SDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGE-MDWRWPFWI----S 181
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVcaalA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 182 LAALPVGLLALSVPLERPHTGMDWKQYARDSRSIIFHSAAIGLFGLTFLCFCILYGPTITYFPLLADLLYKATPSHIGAV 261
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 262 FTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVlpdaVSSLWWLTLPIFIGGVAQGLTFPLLNARMTTL 341
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL----ATSFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 491167012 342 APTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGIGVALVIGALVWR 398
Cdd:cd17325 317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-365 |
1.27e-45 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 160.52 E-value: 1.27e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 15 QSRPVSLAGLVLVLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGL 94
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 95 LLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGE-MD 173
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADlFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 174 WRWPFWISLAALPVGLLALSVPLERPHTGMDwKQYARDSRSIIFHSAAIGLFGLTFLCFCILYGpTITYFPLLADLLYKA 253
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRPAAR-ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFA-LFTYLPLYLQEVLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 254 TPSHIGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVLPdavsSLWWLTLPIFIGGVAQGLTFPL 333
Cdd:COG2814 241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGLLFPL 316
|
330 340 350
....*....|....*....|....*....|..
gi 491167012 334 LNARMTTLAPTRNRAIVMAMNGTVLRLSQSLS 365
Cdd:COG2814 317 LQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
24-399 |
1.12e-35 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 134.63 E-value: 1.12e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMG 103
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 104 CAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGE-MDWRWPFWIsL 182
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLfFGWRAIFVF-L 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 183 AALPVGLLALSV-----PLERPHTGMDWKQYARDSRSIIFHSAAIGLFGLTFLCFCILYGpTITYFPLLADLLYKATPSH 257
Cdd:cd17320 160 ALLGLLLLLLVLlflpeTLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFA-YLAAAPFIYIEQLGLSPAQ 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 258 IGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVLPDA-VSSLWWLTLPIFIGGVAQGLTFPLLNA 336
Cdd:cd17320 239 FGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLgGLSLWPLVAPLFLIFFGFGLIFPNATS 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491167012 337 RMTTLAPTRnRAIVMAMNGTVLRLSQSLSPLFfgIGWSYIGWRGPYAMGIGVALVIGALVWRV 399
Cdd:cd17320 319 LALEPFPHV-AGTASALLGFLQFLIGALAGAL--VGLLPNGTALPMGLLILVLGLLALLLLIL 378
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
27-365 |
1.86e-34 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 131.14 E-value: 1.86e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 27 VLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAF 106
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 107 SDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGE-MDWRWPFWISlaaL 185
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLElFGWRWIFLIN---V 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 186 PVGLLALsvplerphtgmdwkqyardsrsIIFHSAAIGLFGLtfLCFCILYGPTITYFPLLADLLYKATPSHIGAVFTVA 265
Cdd:cd17321 158 PIGLVAL----------------------LLARTFSGAVLAA--FLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 266 SLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVLPdAVSSLWWLTLPIFIGGVAQGLTFPLLNARMTTLAPTR 345
Cdd:cd17321 214 ALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLG-ADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKE 292
|
330 340
....*....|....*....|
gi 491167012 346 NRAIVMAMNGTVLRLSQSLS 365
Cdd:cd17321 293 KAGAASGILNTARQLGGALG 312
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
31-343 |
3.24e-34 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 130.77 E-value: 3.24e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 31 ALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSF 110
Cdd:cd17503 5 AFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 111 ENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGE-MDWRWPFWISlaaLPVGL 189
Cdd:cd17503 85 ASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDnLSWRWIFYIN---LPIGI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 190 LAL-SVPLERPHTGMDwkqyardsRSIIFHSAAIGLFGLTFLCfcilygpTITYFPLLADLLYKATPSHIGAVFTVASLG 268
Cdd:cd17503 162 LALlLAPLLDLRLFKD--------RNFTLGLLLSFLLGLGLFG-------AMFLLPLYLQNVLGYSAFESGLVLAPGGLA 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491167012 269 TAAIAMNLAWLGRKYSHRRLMLSATCCYVVAqTLMLVLPDAVSSLWWLTLPIFIGGVAQGLTF-PLLNARMTTLAP 343
Cdd:cd17503 227 SAILSPLVGRLLDKFGPRLLLLAGLLLLALG-TLLLAFLTPDTSLWLIILPLFIRGLGMGLVFmPLNTLALNSLPP 301
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
27-366 |
2.37e-33 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 127.53 E-value: 2.37e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 27 VLCVALMGVMGVSITLPILPK-LGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCA 105
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 106 FSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGEM-DWRWPFWISLAA 184
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLfGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 185 LPVGLLALSVPLERPHTG-----MDWKQYARDSRSIIFHSAAIGLFgLTFLCFCILYGPTITYFPLLADlLYKATPSHIG 259
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKrpkpaEEARLSLIVAWKALLRDPVLWLL-LALLLFGFAFFGLLTYLPLYQE-VLGLSALLAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 260 AVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVLPDAVSSLWWLTLPIFIgGVAQGLTFPLLNARMT 339
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLL-GFGFGLVFPALNALVS 317
|
330 340
....*....|....*....|....*..
gi 491167012 340 TLAPTRNRAIVMAMNGTVLRLSQSLSP 366
Cdd:pfam07690 318 DLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
24-401 |
3.30e-31 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 122.29 E-value: 3.30e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVALMGVMGVSITLpILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMG 103
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSV-AAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 104 CAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGE-MDWRWPFWIsL 182
Cdd:COG2271 92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAaFGWRAAFLI-L 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 183 AALPVGLLALSVplerphtgmdwkqyardsrsiifhsaaIGLFGLTFLCFCILYGpTITYFPLLADLLYKATPSHIGAVF 262
Cdd:COG2271 171 GLPGLLLALLRF---------------------------WLLALAYFLVYFALYG-FLTWLPTYLVEVRGLSLAQAGLLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 263 TVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCyvVAQTLMLVLPDAVSSLWWLTLPIFIGGVAQGLTFPLLNARMTTLA 342
Cdd:COG2271 223 SLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGL--LLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 491167012 343 PTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGIGVALVIGALVWRVYP 401
Cdd:COG2271 301 PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
43-397 |
1.08e-30 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 120.73 E-value: 1.08e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 43 PILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGL 122
Cdd:cd17324 20 GLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 123 GAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGEM-DWRWPFWIS--LAALPVGLLALSVPLERP 199
Cdd:cd17324 100 AHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlGWRAAFLAIavLALLAALLLWRLLPSLPP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 200 HTGMDWKqYARDSRSIIFHSAAIGLFGLTFLCFCILYGpTITYFPLLADLLYKATPSHIGAVFTVASLGTAAIAMNLAWL 279
Cdd:cd17324 180 KKPGSLG-LLSSLLLLLRNPRLRLAYLITFLLFGGFFA-LYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 280 GRKYSHRRLMLSATCCYVVaqtlMLVLPDAVSSLWWLTLPIFIGGVAQGLTFPLLNARMTTLAPtRNRAIVMAMNGTVLR 359
Cdd:cd17324 258 ADRGGRRALLIALLLLAAA----LLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYN 332
|
330 340 350
....*....|....*....|....*....|....*...
gi 491167012 360 LSQSLSPLFFGIGWSYIGWRGPyAMGIGVALVIGALVW 397
Cdd:cd17324 333 LGGALGAALGGLVLDHGGWAGV-GWVGAALLLLALLLA 369
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
28-390 |
1.76e-30 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 119.59 E-value: 1.76e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 28 LCVAL-MGVMGVSITLPILPKLGAVFHqDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAF 106
Cdd:cd17502 1 LMLALfLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 107 SDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGE-MDWRWPFWISlaaL 185
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDhLSWRWCFYIN---L 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 186 PVGLLALSVplerphtgmdwkqyardSRSIIFHSaaiglfgLTFLCFCILYGPTITYFPLLADLLYKATPSHIGAVFTVA 265
Cdd:cd17502 157 PIGGLALAL-----------------LRTILLSS-------IFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 266 SLGTAAIAMNLAWL-GRKYSHRRLMLSATCCYVVAQTLMLVLpDAVSSLWWLTLPIFIGGVAQGLTFPLLNARMTTLAPT 344
Cdd:cd17502 213 IIGLVIGSIISGALiSKTGRYKPLIVIGTILMSVGAGLLTTL-TLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPP 291
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 491167012 345 RNRAIVMAMNGtvlrLSQSLSPLFFG-IGWSYIGWRGPYAMGIGVAL 390
Cdd:cd17502 292 ADVGVATATNT----FFRSLGGTLGVaITDVFLVALALAALAFLLSL 334
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
32-397 |
1.26e-27 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 112.30 E-value: 1.26e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 32 LMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFE 111
Cdd:cd17489 6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 112 NLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFL-GEMDWRWPFWISLAALPVGLL 190
Cdd:cd17489 86 LLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLyQHLGFAVLFIVAAVLALLALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 191 ALSVPLERPHTGMDWKQYARDSRSIIFHSAAIgLFGLTFLCFCILYGPTITYFPLLADLLykaTPSHIGAVFTVASLGTA 270
Cdd:cd17489 166 LVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVL-PPALILFLASIAYGAISTFLPLYAAER---GISNAGLFFTVYAIALL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 271 AIAMNLAWLGRKYSHRRLMLSatcCYVVAqTLMLVLPDAVSSLWWLTLPIFIGGVAQGLTFPLLNARMTTLAPTRNRAIV 350
Cdd:cd17489 242 LSRPFSGKLSDRKGPKTVIIP---GLLLL-ALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAA 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 491167012 351 MAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGIGVALVIGALVW 397
Cdd:cd17489 318 NGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
27-397 |
1.33e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 106.74 E-value: 1.33e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 27 VLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAF 106
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 107 SDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGEM---DWRWPFWISLA 183
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgfGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 184 ALPVGLLALSVPLERPH------TGMDWKQYARDSRSIIFHSAAIGLFGLTFLCFCILYGPTITYFPLLADLLYKATPSH 257
Cdd:cd06174 161 LALLAAILLLLVVPDPPesarakNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 258 IGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCcyvVAQTLMLVLPDAVSSLWWLTLPIFIGGVAQGLTFPLLNAR 337
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGL---LLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491167012 338 MTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWS-YIGWRGPYAMGIGVALVIGALVW 397
Cdd:cd06174 318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
27-366 |
1.95e-25 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 106.12 E-value: 1.95e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 27 VLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAF 106
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 107 SDSFENLLAWRAIQGLGAAPLGILYGtLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGEM-DWRWPFWIslAAL 185
Cdd:cd17504 81 APNLPVLIAGRALQGIGGAVFPLAFA-LVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHlGWRWIFWT--AAP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 186 PVGLLALSVPLerphtgMDWKQYARdsRSIIFHSAAIGLFGLTFLcfcILYGPTITYFPLLADLLYKATPSHIGAVFTVA 265
Cdd:cd17504 158 VAVLLAALVPL------IDLRLLRR--RNVLLANITALLAGFGMF---MVFQLLPQLLQLPTPTGFGLGITEAGLLLLPG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 266 SLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVLPdavSSLWWLTLPIFIGGVAQGLTFPLLNARMTTLAPTR 345
Cdd:cd17504 227 ALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLH---SSLWALVVALLLIGIGLGLAFASLPNIVVESVPPD 303
|
330 340
....*....|....*....|.
gi 491167012 346 NRAIVMAMNGTVLRLSQSLSP 366
Cdd:cd17504 304 RTGIATGMNTVLRTIGSAIGP 324
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
27-392 |
2.07e-25 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 105.74 E-value: 2.07e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 27 VLCVALMGVMGVSITLPILPKLGA---VFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMG 103
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVRefnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 104 CAFSDSFENLLAWRAIQGLGAAPLGILyGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGEMD-WRWPFWISL 182
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSVA-QAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYgYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 183 AALPVGLLALSVPLERphtgmdwkqyardsrsiifhsaaIGLFGLTFLCFCILYGPTITYFPLLADLLYKATPSHIGAVF 262
Cdd:cd17330 160 ALALLNLVLVLFFLPP-----------------------LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 263 TVASLGTAAIAMNLA-WLGRKYSHRRLMLSATCCYVVAqtlMLVLPdAVSSLWWLTLPIFIGGVAQGLTFPLLNARMTTL 341
Cdd:cd17330 217 ALVGIAGILAQLLLIpRLAKRLGERKLLRLGLLLAIIG---LLLLP-FASSVPLLVLAAAILAFGTGIVFPALSALLSKS 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 491167012 342 APTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGIGVALVI 392
Cdd:cd17330 293 VPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIA 343
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
21-400 |
5.43e-25 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 105.35 E-value: 5.43e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 21 LAGLVLVLCVALMGVMGVSitlPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACG 100
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWS---VLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 101 GMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFL-GEMDWRWPFW 179
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLiAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 180 ISLAALPVGLLALSVPLERPHTGMDWKQYA--RDSRSIIFHSAAIGLFGLTFLCFCILYGPtITYFPLLADLLYKATPSH 257
Cdd:COG2223 164 ILGILLLVVAVLAWLFLRDPPAGAAAAAKAslRDQLEALRDPRFWLLSLLYFGTFGSFIGF-SSWLPPYLVDQFGLSAAT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 258 IGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSAtccYVVAQTLMLVLPDAVSSLWWLTLPIFIGGVAQGLTFPLLNAR 337
Cdd:COG2223 243 AGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIV---FALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFAL 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491167012 338 MTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIG-WRGPYAMGIGVALVIGALVWRVY 400
Cdd:COG2223 320 VPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
24-400 |
6.52e-25 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 105.00 E-value: 6.52e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVALMGVMGVSITLPILPK-LGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGM 102
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIyLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 103 GCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGEMDWRWPFWISL 182
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 183 AA--LPVGLLALSVPLERPHTGMDWKQYARDSRSIIFHSAAIGLFGLTFLCFCILYGPTITYFPLLADLLYKATPSHIGA 260
Cdd:cd17329 161 VLflLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 261 VFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAqtlMLVLPdAVSSLWWLTLPIFIGGVAQGLTFPLLNARMTT 340
Cdd:cd17329 241 LLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIG---FAVLA-FANTLAVLILAMIVLTLGEMLVFPAVQTLVAA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 341 LAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGIGVALVIGALVWRVY 400
Cdd:cd17329 317 LAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
24-370 |
2.51e-23 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 100.77 E-value: 2.51e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMG 103
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 104 CAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGE--MDWRWPFWIS 181
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQatGGWRWAFRVT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 182 --LAALPVGLLALSVP----------LERPHTGMDWKQYARDSRSIifHSAAIGLFGLTFLCFCIL-YGPTITYFPLLAD 248
Cdd:cd17328 161 gvLGVLLAILLLLFVRepprgaaeggVMAKSTATSFLADLKALAKN--PSFILSTLGFTAVSFVTGaLAFWAPTFFLRAF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 249 LLYKATPSHIGAVFTVAS-----LGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVLPDAVSSLWWLTLPIFIG 323
Cdd:cd17328 239 GVGDLSSADVGLIFGAITciagvLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLG 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 491167012 324 GVAQGLTFPLLNARMTTLAPTRNRAIVMAMNGTVLR-LSQSLSPLFFG 370
Cdd:cd17328 319 EFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHlLGDAGSPYLIG 366
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-280 |
4.94e-23 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 97.96 E-value: 4.94e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 10 ASQEGQSRPVSLAGLVLVLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAV 89
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 90 LLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFL 169
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 170 GE-MDWRWPFWISLAALPVGLLALSVPLERPHTGMDWKQYARDSRSIIFHSAAIGLFGLTFLCFCILYGPTITYFPLLAD 248
Cdd:COG0477 162 VAaLGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLL 241
|
250 260 270
....*....|....*....|....*....|..
gi 491167012 249 LLYKATPSHIGAVFTVASLGTAAIAMNLAWLG 280
Cdd:COG0477 242 LLALLLLALLLLLALLLLAALLLLLLLLLLLA 273
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
24-406 |
7.47e-23 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 99.16 E-value: 7.47e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVALMGVMGVSITL--PILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGG 101
Cdd:COG0738 8 RALIAIYLLFFLWGFATALwgPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 102 MGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEAdRPKVMGMVGATISFGTALYPAIGGFL----GEMDWRWP 177
Cdd:COG0738 88 LLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLillgLSLSWHLP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 178 FW-ISLAALPVGLLALSVPLERPHTGMDWKQYARDSRSIIFHSAAIGLFGLTFLCFCILYGPTITYFPLLADLLYKATPS 256
Cdd:COG0738 167 YLiLAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 257 HIGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVLPDAVSSLWWLtlpiFIGGVAQGLTFPLLNA 336
Cdd:COG0738 247 TAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGL----ALVGLGLSLMFPTIFS 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 337 rMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGIGVALVIGALVWRVYPVSSGK 406
Cdd:COG0738 323 -LALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
16-399 |
3.25e-22 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 97.25 E-value: 3.25e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 16 SRPVSLAGLVLVLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLL 95
Cdd:COG2807 12 RRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 96 LFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEaDRPKVMGMVGATISFGTALYPAIGGFLGEM-DW 174
Cdd:COG2807 92 LLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAAlGW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 175 RWPFWIsLAALPVGLLALSVPLERPHTGMDWKQYARDSRSIIFHSAAIGLFGLTFLCFCILYGPTITYFP-LLADLLYka 253
Cdd:COG2807 171 RGALAV-WALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPpILRDAGL-- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 254 TPSHIGAVFTVASLGTAAIAMNLAWLGRKYSHRR-LMLSATCCYVVAQTLMLVLPDAVSSLWwltlpIFIGGVAQGLTFP 332
Cdd:COG2807 248 SAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRpLLLLLGLLGLAGLLGLLLAPGSLPWLW-----AVLLGLGQGGLFP 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491167012 333 LLNARMTTLAPT-RNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIG-WRGPYAMGIGVALVIGALVWRV 399
Cdd:COG2807 323 LALTLIGLRARTpAEAAALSGMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
24-398 |
1.79e-21 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 94.99 E-value: 1.79e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMG 103
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 104 CAFSDSFENLLAW-----RAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFL-GEMDWRWP 177
Cdd:cd06173 81 LALLALLGSLSLWlllvlAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLvALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 178 FWISLAALPVGLLALS-----VPLERPHTGMDWKQYARDSRSIIFHSAAIGLFGLTFLCFCILYGPTITYFPLLADLLYK 252
Cdd:cd06173 161 FAINALSFLLSALLLLfirrpPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 253 ATPSHIGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMlvlpdAVSSLWWLTLPI-FIGGVAQGLTF 331
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVL-----GLSPSLWLLLAAlFLLGLAGGLFN 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491167012 332 PLLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGIGVALVIGALVWR 398
Cdd:cd06173 316 VPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
24-196 |
2.79e-20 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 92.44 E-value: 2.79e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVAL-MGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGM 102
Cdd:TIGR00711 3 LTIVLMLGTfMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 103 GCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGE-MDWRWPFWIS 181
Cdd:TIGR00711 83 LCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIEnYHWRWIFLIN 162
|
170
....*....|....*
gi 491167012 182 laaLPVGLLALSVPL 196
Cdd:TIGR00711 163 ---VPIGIIVVVVAF 174
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
27-180 |
5.44e-19 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 87.63 E-value: 5.44e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 27 VLCVALMGV---MGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMG 103
Cdd:cd17323 1 VFIISFLTFvvtFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491167012 104 CAFSDSFENLLAWRAIQGL-GAAPLGILYGTlVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGE-MDWRWPFWI 180
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFfGSSPLAIGAGT-IADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQsLGWRWIFWF 158
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
20-209 |
6.39e-18 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 84.74 E-value: 6.39e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 20 SLAGLVLVLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFAC 99
Cdd:TIGR00710 3 AKAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 100 GGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGE-MDWRWPF 178
Cdd:TIGR00710 83 SSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVwLSWHAIF 162
|
170 180 190
....*....|....*....|....*....|....*....
gi 491167012 179 WIsLAALPVGLLAL--------SVPLERPHTGMDWKQYA 209
Cdd:TIGR00710 163 AF-LSLAGILLSALiffilpetLPYEARIQISTYFETFL 200
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
24-396 |
3.75e-17 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 82.30 E-value: 3.75e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFM----TPVAGVLADRFGRKAVLLPGLLLFAC 99
Cdd:cd17388 1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGDSADAATHYGVLLALYALMqfifAPILGALSDRFGRRPVLLLSLAGAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 100 GGMGCAFSDSFENLLAWRAIQGLGAAPlGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGEMDWRWPFW 179
Cdd:cd17388 81 DYLLMAFAPTLWWLYLGRIIAGITGAT-GAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 180 ----ISLAALPVGLLAL--SVPLERpHTGMDWK--QYARDSRSIIFHSAAIGLFGLTFLCFCILYGPTiTYFPLLADLLY 251
Cdd:cd17388 160 vaagLNGLNFLLGLFVLpeSLPPER-RRAFRWRraNPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPA-TTWVLFTEDRF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 252 KATPSHIGavFTVASLGTAAI---AMNLAWLGRKYSHRRLMLSATCCYVVAQTLMlvlpdAVSSLWWLTLPIFIGGVAQG 328
Cdd:cd17388 238 DWSPTMVG--LSLAVFGLLHAlfqAFVTGPIAKRLGEKRAILLGLAADALGFLLL-----AFATQGWMVFPILILLALGG 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 329 LTFPLLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGI--GWSYIGWRGpYAMGIGVALVIGALV 396
Cdd:cd17388 311 IAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGifAASPATWPG-LAWIIGAALYLICLV 379
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
26-396 |
5.04e-17 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 81.84 E-value: 5.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 26 LVLCVALMGVmGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCA 105
Cdd:cd17477 1 LLLSVALLGL-GSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 106 FSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGEMDWRwPFWIS---- 181
Cdd:cd17477 80 LTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL-PFLIAavll 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 182 -LAALPVGLLALSVPLERPHTGMDWKQYARDSRSIIFHSAAIGLFGLTFLCFCILYGPTITYfplladllykaTPSHIGA 260
Cdd:cd17477 159 lLALVPLLLTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGL-----------SVAQAAL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 261 VFTVASLGTAAIAMNLAWLGRKYSHRRLMLsatCCYVVAQTLMLVLPDAVSSLWWLTLPIFIGGVAQGLTFPLLNARMTT 340
Cdd:cd17477 228 LLAAFVLGGLLLQWPLGWLADRFDRRRVLL---GCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGD 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 491167012 341 LAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGIGVALVIGALV 396
Cdd:cd17477 305 RLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
61-180 |
5.65e-17 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 76.92 E-value: 5.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 61 LLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYK 140
Cdd:TIGR00880 2 LLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 491167012 141 EADRPKVMGMVGATISFGTALYPAIGGFLGEMD-WRWPFWI 180
Cdd:TIGR00880 82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQFLgWRAPFLF 122
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
44-393 |
5.86e-17 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 81.96 E-value: 5.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 44 ILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLG 123
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 124 AAPLGILYGTLVGDFYKEADRPKVMGMVGATISFG----TALYP-AIGGFLGEMDWRWPFWISLA-ALPVGLLALSVP-- 195
Cdd:cd17371 101 FGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGwllaTLLAAlLFPLLPPEIAWRVLFLLGALpALLVLFIRRFVKep 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 196 ---LERPHTGMDWKQyaRDSRSIIFHSAAIGLFGLTFLCFCILYGptiTYFPLLADL-LYKATPSHIGAVFTVASLGTAA 271
Cdd:cd17371 181 pqwQAARAARRHFAD--RPSLRELFSPPLLRTTLLASLLATGALG---GYYGITTWLpSYLTGERGLSFEGSAGYLVVTI 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 272 IAMNL-----AWLGRKYSHRRLMLSATCCYVVAQTLMLVLPDAVSSLWWLtlpIFIGGVAQGLTFPLLNARMTTLAPTRN 346
Cdd:cd17371 256 LGGFLgylagGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILIL---GFPLGFFASGPFSGMGAYLTELFPTAV 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 491167012 347 RAIVMAMNGTVLRLSQSLSPlfFGIGW--SYIGWRGPYAMGIGVALVIG 393
Cdd:cd17371 333 RATAQGFCYNVGRIIGALFP--FLVGFlaTSGSLGTAIAVFAAVYYIAG 379
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
78-397 |
8.28e-16 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 78.41 E-value: 8.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 78 GVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILygTLVGDFYKEADRPKVMGMVGATISF 157
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISSVVM--ALLADLTREENRTKAMALIGASIGI 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 158 ----GTALYPAIGGFLGemdWRWPFWIS--LAALPVGLLALSVPLERPHTGMDWKQYARdSRSIIFHsaaIGLFGLTFLC 231
Cdd:cd17472 131 afaiSMVLGPLLAAHLG---VSGLFLITaiLSLVSLLILLFFVPDPPKIVQISEKEKKK-LKKLLKN---KRLLRLDFSI 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 232 FCILYGPTITYF--PLLADLLYKATPSHIGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVlpdA 309
Cdd:cd17472 204 FILHFVLMAFFYilPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLF---A 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 310 VSSLWWLTLPIFIGGVAQGLTFPLLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGIGVA 389
Cdd:cd17472 281 ATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILA 360
|
....*...
gi 491167012 390 LVIGALVW 397
Cdd:cd17472 361 LLWLLVSF 368
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
56-403 |
1.40e-15 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 78.02 E-value: 1.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 56 AAGVALLITCFTlpSAFMTPVAGVLADRFG-----RKAVLLPGLLLFACGGMGCAFSDSFEN------LLAWRAIQGLGA 124
Cdd:COG2211 47 LVGLILLVARLW--DAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLSPtgkliyALVTYLLLGLAY 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 125 APLGILYGTLVGDFYKEAD-RPKVMGMVGATISFGTALYPAIGGFLGEM-------DWRWPFWISLAALPVGLLALSVPL 196
Cdd:COG2211 125 TLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaalGYRLTALIFAVLGLLAFLLTFFGT 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 197 ERPHTGMDWKQYARDSRSIIFHSAAIGLFGLTFLCFCILYGPTITYFPLLADLLYKATPSHIGAVFTVASLGTAAIAMNL 276
Cdd:COG2211 205 KERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLW 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 277 AWLGRKYSHRRLMLSATCCYVVAQTLMLVLPDavSSLWWLTLPIFIGGVAQGLTFPLLNARMTTLAP-------TRNRAI 349
Cdd:COG2211 285 PRLAKRFGKKKAFIIGLLLAALGLLLLFFLGP--GNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGL 362
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491167012 350 VMAMNGTVLRLSQSLSPLFFGIGWSYIGW--------------RGPYAMGIGVALVIGALVWRVYPVS 403
Cdd:COG2211 363 YFGIFTFAIKLGQALAGALAGLLLALFGYvagaaqspsaltgiRLLFFLLPAVLLLLAALLLLFYPLT 430
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
42-192 |
2.75e-14 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 73.80 E-value: 2.75e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 42 LPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQG 121
Cdd:PRK11102 11 LPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHG 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491167012 122 LGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGE-MDWRWPFW-ISLAALPVGLLAL 192
Cdd:PRK11102 91 LAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVwFSWHAIFWvLALAAILAAALVF 163
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
78-397 |
2.85e-13 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 70.32 E-value: 2.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 78 GVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISF 157
Cdd:cd17316 57 GYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWAL 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 158 GTALYPAIGGFLGEM-----DWRWPFWISlaalpvGLLALSVPLERPHTGMDWkqyardsrsiifhsaaiglfgLTFLCF 232
Cdd:cd17316 137 GALLAALVASLLIPLlsgdwGWRILFLIG------ALPALLALLLRRRTLLLI---------------------LLWFFI 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 233 CILYGPTITYFPLLADLLYKATPSHIGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVLPDAvsS 312
Cdd:cd17316 190 SFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSG--S 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 313 LWWLTLPIFIGGVAQGLTFPLLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGIGVALVI 392
Cdd:cd17316 268 PTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIV 347
|
....*
gi 491167012 393 GALVW 397
Cdd:cd17316 348 ALIVA 352
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
24-399 |
5.09e-13 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 69.99 E-value: 5.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVALMGVMGVSITLPI-LPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGM 102
Cdd:cd17355 4 VLAVTFLILILSWGIRYYFGVfIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 103 GCAFSDS-FENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFG-TALYPAIGGFLGEMDWRWPFWI 180
Cdd:cd17355 84 LLALATSlWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGsLVFLPLGAALIEAFGWRTALLV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 181 sLAALPVGLLALSVPLERPHTgmdWKQYARDSRSIIFHSAAIGLFGLT------------FLCFCILYGPTITYFPLLAD 248
Cdd:cd17355 164 -LALLALLVLVPVLLLLRRRP---ADLALRAYDDASPASPGSTLKEALrsasfwllalafFLCGFAVVGLIVHLVPYLAD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 249 LLYkatpSHIGAVFTVASLGTAAIAMNLA--WLGRKYSHRRLMLSATCCYVVAQTLMLVLPDAVSSLWwltLPIFIGGVA 326
Cdd:cd17355 240 RGI----SPAAAAVALALIGLFNIVGRLLsgWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALL---LFAALFGLG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491167012 327 QGLTFPLLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIG-WRGPYAMGIGVALVIGALVWRV 399
Cdd:cd17355 313 WGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALLVLPI 386
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
219-403 |
1.27e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 68.46 E-value: 1.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 219 SAAIGLFGLTFLCFCILYGPTItYFPLLADLL--YKATPSHIGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCY 296
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGI-VLPALPLIAadLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 297 VVAQTLMLVLPdavsSLWWLTLPIFIGGVAQGLTFPLLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYI 376
Cdd:COG2814 86 ALGSLLCALAP----SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180
....*....|....*....|....*..
gi 491167012 377 GWRGPYAMGIGVALVIGALVWRVYPVS 403
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPES 188
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
45-196 |
2.28e-12 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 68.00 E-value: 2.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 45 LPKLGAV---FHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQG 121
Cdd:PRK11043 26 LPAFKAIqadLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQA 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491167012 122 LGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGF-LGEMDWRWPFwISLAALPVGLLALSVPL 196
Cdd:PRK11043 106 VGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWlLNHFGWQAIF-ATLFAITLLLILPTLRL 180
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
43-334 |
2.43e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 67.58 E-value: 2.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 43 PILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGL 122
Cdd:cd17478 17 ALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 123 GAA---PLGILYGTLVGdfykEADRPKVMGMVGATISFGTALYPAIGGFLGEMDW--RWPFWISLAALPVGLLALSVPLE 197
Cdd:cd17478 97 GSAafhPEGARLASQAA----GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGglGLLILLIIPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 198 RPHTGMDWKQYARDSRSIIFHSAAIGLFGLTFLCFCILYGPTITYFPLLAdLLYKATPSHIGAVFTVASLGTAAIAMNLA 277
Cdd:cd17478 173 KKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYL-VQRGYSLVFAGLLLSLFLFAGAIGTLIGG 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 491167012 278 WLGRKYSHRRLMLSATCCYVVAQTLMLVLPdavssLWWLTLPIFIGGVAQGLTFPLL 334
Cdd:cd17478 252 PLSDRFGRRRVIIASLLLAAPFLLLFLLTP-----GIWSYILLVLAGFLLFASFPVT 303
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
78-400 |
3.04e-12 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 67.25 E-value: 3.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 78 GVLADRFG-RKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAApLGILYGTLVGDFYKEADRPKVMGMVGATIS 156
Cdd:cd17490 52 GILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAA-TWVSFTVLYASYFPPDEAAKAMGLINLVNN 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 157 FGTALYPAIGGFLGE-MDWRWPFWISLAALPVGL-LALSVPLERPHTgMDWKQYARDSRSIIFHSAAIGLFGLTFLCFCI 234
Cdd:cd17490 131 LGQLIAFLIGGLIAEhFGMRAPFLLAALAGVLGFiLSLFIKEERREK-KPVLTELKELLSVLKDKKLLFFSLLAILQQMI 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 235 LYGPTITYFPLLADLLyKATPSHIGAVfTVASLGTAAIAMNLA--WLGRKYSHRRLMLSAtccyVVAQTLMLVLPDAVSS 312
Cdd:cd17490 210 TFSTTFGFTPLIAKQL-GASSFQLGLL-SIIYLLPNALASLLSgtLFYKKLGERNTIIIG----FLLLGAYCFLIPFAPN 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 313 LWWLTLPIFIGGVAQGLTFPLLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPYaMGIGVALVI 392
Cdd:cd17490 284 LTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGF-FVIGVIALL 362
|
....*...
gi 491167012 393 GALVWRVY 400
Cdd:cd17490 363 AAILSLAY 370
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
30-399 |
3.30e-12 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 67.25 E-value: 3.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 30 VALMGVMGVSITLPILP----KLGAvfhqDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCA 105
Cdd:cd17390 4 VGFLDLFGVSMILPLLSthirSLGA----SPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 106 FSDSFENLLAWRAiqglgaaPLGILYGT------LVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGEMD--WRWP 177
Cdd:cd17390 80 FSTSLALLFLSRI-------PLGIFKHTqslckaYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDggFYYV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 178 FWISLAA--LPVGLLALSVPLerphtgmdwkqyARDSRSIIFhsaaigLFGLTFLCFcilygptITYFPLLADLLYKATP 255
Cdd:cd17390 153 ALLCSAIfiLNAGLVWFLLSK------------LWDLLLVRF------LMGFSVLLF-------RSNFSLYLEERFDLSP 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 256 SHIGAVFTVASLGTAAIAMNLAWLGRKYSHR--RLMLSATCCYVVAQTLMLVlpdaVSSLWWLTLPIFIGGVAQGLTFPL 333
Cdd:cd17390 208 KTIGYLISYSGVLGALSGFLVGRILKLYKNNeyLLLLHSFILLALSLLGLAL----APSIWLLVLCLTPLSISSAVLRTC 283
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491167012 334 LNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWrGPYAMGIGVALVIGALVWRV 399
Cdd:cd17390 284 STSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVS-GPGLLGAVLALAAILLMLAR 348
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
24-199 |
3.54e-12 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 67.24 E-value: 3.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVALmGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMG 103
Cdd:PRK11652 11 FMLVLLVAV-GQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 104 CAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGEM-DWRWPFW--I 180
Cdd:PRK11652 90 ALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLfGWRACYLflL 169
|
170
....*....|....*....
gi 491167012 181 SLAALPVGLLALSVPLERP 199
Cdd:PRK11652 170 LLGAGVTFSMARWMPETRP 188
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
37-379 |
1.11e-11 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 65.75 E-value: 1.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 37 GVSITLPILP----KLGAVFHQDA---AGVALLITCFTlpSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDS 109
Cdd:cd17391 11 GFSLIAPFLPlyieQLGVTSGGLVelwSGLAFSSTFLV--SAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTN 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 110 FENLLAWRAIQGL--GAAPLGIlygTLVGdfyKEADRPK---VMGMVGATISFGTALYPAIGGFLGEM-DWRWPFWI-SL 182
Cdd:cd17391 89 VWQLLILRLLQGVfsGYVPNAT---ALIA---SQTPKEKsgwALGTLSTGVVAGTLIGPLLGGFLADLfGIRNVFFItGG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 183 AALPVGLLALSVPLE--RPHTGMDWKQYARDSRSIIFHSAAIGLFGLTFLCFCILY--GPTITYF--PLLADLLYKATPS 256
Cdd:cd17391 163 LLFLAFLLTLFFVKEdfKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQsiEPILTLYirQLMGDASNLAFIS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 257 hiGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCcyvvAQTLMLVLPDAVSSLWWLTLPIFIGGVAQGLTFPLLNA 336
Cdd:cd17391 243 --GLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALL----ASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINS 316
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 491167012 337 RMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWR 379
Cdd:cd17391 317 LLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYR 359
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
26-237 |
4.59e-11 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 64.18 E-value: 4.59e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 26 LVLCVALM-GVMGVSITLPILPKLGAVFHQDAAgVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGC 104
Cdd:cd06179 1 AALCLAYFaQLFGVTLPAAVLPFIVADLGPSSN-STWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 105 AFSDSFENLLAWRAIQGLGAAPLGILY---GTLVGDFYkeadRPKVMGMVGATISFGTALYPAIGGFLGEMD---WRWPF 178
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGTQGLGAavaSELVPNKY----RGLVQGVVNLVASPGSALGPLIAGALVEANaagWRWIF 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491167012 179 WISL---AALPVGLLALSVPLERPhtgmdwKQYARDSRSIIFHSAAIGLFGLTFLCFCILYG 237
Cdd:cd06179 156 YINAifnALALILLFFFYHPPPRP------QLHGSSTRQKLKRLDWVGLFLLIAGLVLFLLG 211
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
54-195 |
5.74e-11 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 63.88 E-value: 5.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 54 QDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGT 133
Cdd:TIGR00898 124 EDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVV 203
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491167012 134 LVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLgeMDWRW-PFWISLAALPVGLLALSVP 195
Cdd:TIGR00898 204 LNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFI--PDWRWlQLAVSLPTFLFFLLSWFVP 264
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
52-397 |
4.38e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 60.66 E-value: 4.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 52 FHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILY 131
Cdd:cd17319 33 LGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 132 GTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFL-GEMDWRWPFWIsLAALPVGLLALsvplerphtgmdWKQYAR 210
Cdd:cd17319 113 IKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLlLLFGWRWAFII-EGLLGLLLAVL------------WWFYLR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 211 dsrsiifhsAAIGLFGLTFLCFCILYGpTITYFPLLADLLYKATPSHIGAVFTVASLGTAAIAMNLAWL-GRKYSHRRLM 289
Cdd:cd17319 180 ---------QVWGLALGYFGINYALYG-LLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLsDRLLRGARRL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 290 LSATCCYVVAQTLMLVLPdaVSSLWWLTLPIFIGGVAQGLTFPLLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFF 369
Cdd:cd17319 250 VIIIGLLLAAVGLLLAYL--TTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLI 327
|
330 340
....*....|....*....|....*...
gi 491167012 370 GIGWSYIGWRGPYAMGIGVALVIGALVW 397
Cdd:cd17319 328 GYLVDATGSYTAAFLFLAAVALLAALLV 355
|
|
| MFS_efflux_LmrB |
NF000060 |
lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters ... |
8-190 |
5.95e-10 |
|
lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters Lmr(B) expression in Bacillus subtilis and allows Lmr(B) to confer resistance to lincomycin.
Pssm-ID: 411077 [Multi-domain] Cd Length: 479 Bit Score: 60.81 E-value: 5.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 8 GEASQEGQSRPVslagLVLVLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRK 87
Cdd:NF000060 7 AKASQQYKVMPI----MISLLLAGFIGMFSETALNIALTDLMKELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 88 AVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGG 167
Cdd:NF000060 83 QLFTVSLIFSILGTFIAALAPSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTFSG 162
|
170 180
....*....|....*....|....
gi 491167012 168 FLGE-MDWRWPFWISLAALPVGLL 190
Cdd:NF000060 163 LVLEhLNWHWIFWISLPFLVLALV 186
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
33-190 |
1.03e-09 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 60.13 E-value: 1.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 33 MGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFEN 112
Cdd:PRK10504 21 MQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 113 LLAWRAIQGLGAA---PLGILygtLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGE-MDWRWPFWISlaaLPVG 188
Cdd:PRK10504 101 LLLARVLQGVGGAmmvPVGRL---TVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEyASWHWIFLIN---IPVG 174
|
..
gi 491167012 189 LL 190
Cdd:PRK10504 175 II 176
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
27-397 |
1.42e-09 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 59.20 E-value: 1.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 27 VLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAF 106
Cdd:cd17476 3 ISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 107 SDSFENLLAWRAIQGLGAA---PLGIlygTLVGDFYKEADRPK-VMGMVGATISFGTALYPAIGGFLGEMD-WRWPFWIs 181
Cdd:cd17476 83 SPNFIFFIICRALQGLGPAfllPNAM---ALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLAwWPWIFWF- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 182 LAALPVGLLALSVPLERPHTGMdwkqyardsrsiifhsaaigLFGLTFLCFCIlYGPTITYFPLLADLLYKATPSHIGAV 261
Cdd:cd17476 159 LAILAAIVAVAAIFWTSPSFIA--------------------VLLAVFLGWAS-FGIWVFYATQYFQNVRGYSPLLTSAR 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 262 FTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVLPDAvSSLWWLTLP-IFIGGVAQGLTFPLLNARMTT 340
Cdd:cd17476 218 FIPMAIGGVLAAITVGFLIARLPPSYIMAISMVAFLVGPILFATMPVH-QTYWAQAFPaMIVAPFGMDFSFPAATIIASN 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491167012 341 LAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYI---------GWRGPYAMGIGVALVIGALVW 397
Cdd:cd17476 297 AVPREYQGLAGSLVNTVVNYGISIGLGIAGTVETSVnedgadllkGYRAAWYLGIGLAALGLLISV 362
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
227-401 |
1.55e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.97 E-value: 1.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 227 LTFLCFCILYGPTITYFPLLADLLYKATPSHIGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVl 306
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 307 pdaVSSLWWLTLPIFIGGVAQGLTFPLLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGI 386
Cdd:pfam07690 82 ---ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170
....*....|....*
gi 491167012 387 GVALVIGALVWRVYP 401
Cdd:pfam07690 159 ILSLLAAVLLLLPRP 173
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
15-192 |
2.23e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 58.91 E-value: 2.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 15 QSRPVSLAGLVLVLCVALMGVMGVSITLP--ILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLP 92
Cdd:TIGR00895 8 KQPLSRYQWRAIILSFLIMLMDGYDLAAMgfAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLW 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 93 GLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLG-E 171
Cdd:TIGR00895 88 SILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIpV 167
|
170 180
....*....|....*....|.
gi 491167012 172 MDWRWPFWISlAALPVGLLAL 192
Cdd:TIGR00895 168 FGWRSLFYVG-GIAPLLLLLL 187
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
36-247 |
1.07e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 56.56 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 36 MGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLA 115
Cdd:cd17333 10 LTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 116 WRAIQGLGAAPLGILYGTLVGDFYKEaDRPKVMGMVGATISFGTALYPAIGGFLG--EMDWRWPFWISLAALPVGLLALS 193
Cdd:cd17333 90 LMFLAGLGAGILDTGANTFVGALFEE-SSATRLNVLHGFFGLGALIGPLIATSLLtsELSWSWAYLIIGLIYLLLAILIL 168
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 491167012 194 VPL--ERPHTGMDWKQYARDSRSII--FHSAAIGLFGLTFLCFCILYGPTITYFPLLA 247
Cdd:cd17333 169 LTLfpELPSARNPQQSVGAFSASASrlLRNPSIILGALALFLYVGAETAFSSWVPSYL 226
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
59-198 |
1.85e-08 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 55.66 E-value: 1.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 59 VALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDF 138
Cdd:cd17317 27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEI 106
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 139 YKEADRPKVMGMVGATISFGTALYPAIGGFLGemDWRWpFWISLAALPVGLLALSVPLER 198
Cdd:cd17317 107 VGPKYRSFVGILFGLFWALGYMLLALLAYLIR--DWRW-LQLAISLPGLLFLLLLWWLPR 163
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
76-396 |
1.90e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 55.67 E-value: 1.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 76 VAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATI 155
Cdd:cd17365 53 LAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGY 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 156 SFGTalypAIGGFLG-----EMDWRWPFWIslAALPVGLLALSVPlerphtgmdwkqyardsrsiifhsAAIGLFGLTFL 230
Cdd:cd17365 133 PLGA----ALGGFLAaalipAFGWRSVFLL--GGVPPLILLPLLR------------------------GTLLLWVTFFM 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 231 CFCILYGpTITYFP-LLADLLYkaTPSHIGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSAtccYVVAQTLMLVLPDA 309
Cdd:cd17365 183 GLLLVYL-LNSWLPkLMVEAGY--SLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALF---FALGAVSLALLGVS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 310 VSSLWWLTLPIFIGGVAQGLTFPLLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLffgIGWSYIGWRGPYAMG---I 386
Cdd:cd17365 257 PASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPL---LGGLLLAAGLGPESVflaL 333
|
330
....*....|
gi 491167012 387 GVALVIGALV 396
Cdd:cd17365 334 AIPAALGALA 343
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
36-228 |
4.80e-08 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 54.66 E-value: 4.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 36 MGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFEnlLA 115
Cdd:cd17396 14 MGVIILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLI--IA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 116 WRAIQGLGAAPLGILYGT---LVGDFYKEADRPKVmgMVGATISFGTALYPAIGGFL--GEMDWRWPFWISLAALPVGLL 190
Cdd:cd17396 92 YVFALLAGAANSFLDTGTypaLMEAFPKASGSANI--LVKAFVSFGQFLLPFIIAFLaaNNLWYGWSFIVPAAVLVLNAL 169
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 491167012 191 ALSV------PLERPHTGMDWKQYARDSRSIIFHSAAIGLFGLT 228
Cdd:cd17396 170 LLLKlsfppqTVTAANTKQKEIPVKREKPKFLIEGIALILIGFT 213
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
253-399 |
9.41e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 53.28 E-value: 9.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 253 ATPSHIGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVLPdavsSLWWLTLPIFIGGVAQGLTFP 332
Cdd:COG0477 46 ASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAP----SPELLIAARALQGIGAGGLMP 121
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491167012 333 LLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGIGVALVIGALVWRV 399
Cdd:COG0477 122 GALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
45-195 |
1.62e-07 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 52.95 E-value: 1.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 45 LPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLG- 123
Cdd:cd17359 24 LPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAv 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 124 --AAPLGILY----------GTLVGDFykeadrpKVMGMVGATISFGTALY---PAIGGFLGEMDWRWPFWI-SLAALPV 187
Cdd:cd17359 104 ggASALVPMYiaevapaeirGRLVSLN-------QLMIVFGQLLAYIVNYLianAGGADWLGAEGWRWMLGLeAIPAILF 176
|
....*...
gi 491167012 188 GLLALSVP 195
Cdd:cd17359 177 LLGMLFIP 184
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
26-171 |
1.65e-07 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 53.19 E-value: 1.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 26 LVLCVALMGVMGVSITLPIL----PKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGG 101
Cdd:PRK14995 6 LTLVIIVLVYIPVAIDATVLhvaaPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLAS 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491167012 102 MGCAFSDSFENLLAWRAIQGLGAAPlgILYGTLVG---DFYKEADRPKVMGMVGATISFGTALYPAIGGFLGE 171
Cdd:PRK14995 86 LAAAFSPTASWLIATRALLAIGAAM--IVPATLAGiraTFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLE 156
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
26-305 |
2.02e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 52.55 E-value: 2.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 26 LVLCVALMGvMGVSITLPILPKLGA-VFHQDAAGVALLITCFTLPSAFMTPVAGVLADR-FGRKAVLLPGLLLFACGGMG 103
Cdd:cd17471 1 LLLATLLTG-LAGAFVLPYLSLFLTeELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 104 CAFSDSFENLLAWRA-IQGLGAAPLGIL--YGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFL-GEMDWRWPFW 179
Cdd:cd17471 80 FAFLRNYWVLLLVGVvLLSLGAAAFPQLfaLAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLlDVLGFTGLFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 180 IS-LAALPVGLLALSVPLERPHTGMDWKQYARDSRSIIfhSAAIGLFGLTFLCFCILYGPTITYFPLLADLLYKATPSHI 258
Cdd:cd17471 160 LAaLLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPV--NRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWV 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 491167012 259 GAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLV 305
Cdd:cd17471 238 GLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLAL 284
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
24-201 |
2.64e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 52.19 E-value: 2.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVALMGVMGVSITLPILpkLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMG 103
Cdd:COG2223 210 LSLLYFGTFGSFIGFSSWLPPY--LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 104 CAF-SDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGEM--DWRWPFWI 180
Cdd:COG2223 288 LALaLGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtgSYTAAFLV 367
|
170 180
....*....|....*....|.
gi 491167012 181 SLAALPVGLLALSVPLERPHT 201
Cdd:COG2223 368 FAVLALVALVLTLLLYRRPRR 388
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
24-192 |
3.03e-07 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 52.19 E-value: 3.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVALMGVMGVSITLPILPKlgavFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMG 103
Cdd:cd17384 2 LVIVYVALLLDNMLLTVVVPIIPD----YLNENVRVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 104 CAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFY-KEADRPKVMGMVGATISFGTALYPAIGG----FLGEMdwrWPF 178
Cdd:cd17384 78 FAFGESYGVLFLARALQGVGSACSSVAGMGMLASLYpDDKERGKAMGIALGGLALGVLVGPPFGGvmyeFVGKS---APF 154
|
170
....*....|....
gi 491167012 179 WIsLAALPVGLLAL 192
Cdd:cd17384 155 LI-LAFLALLDGAL 167
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
227-401 |
4.93e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 51.27 E-value: 4.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 227 LTFLCFCILYGPTITYFPLLADLL-YKATPSHIGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLV 305
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQsFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 306 LPdavsSLWWLTLPIFIGGVAQGLTFPLLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYI--GWRGPYA 383
Cdd:cd06174 81 AP----SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFL 156
|
170
....*....|....*...
gi 491167012 384 MGIGVALVIGALVWRVYP 401
Cdd:cd06174 157 IAAALALLAAILLLLVVP 174
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
74-378 |
4.94e-07 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 51.14 E-value: 4.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 74 TPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGA 153
Cdd:cd17374 52 ALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSC 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 154 TISFGTALYPAIGgfLGEMDWRWPFwislaalpvglLALSVPLerphtgmdwkqyardsrsIIFHSAAIGLFGLTFLCFC 233
Cdd:cd17374 132 FFSIGQMLLAGLA--YAIRDWRLLQ-----------LVVSVPF------------------FLFFLYSWWLPKRTLILSF 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 234 ILYGPTITYFPLLADLLYKATPSHI-----GAVFTVASLGTAAIamnLAWLGRKYSHRRLM-LSATCCyvvaqTLMLVLP 307
Cdd:cd17374 181 VWFANSFSYYGLSLDLQHLGLNVFLlqflfGAVEVPARCLALFL---LNHMGRRISQAVLLlLAGLCI-----LANIFVP 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491167012 308 DAVSSLWWLTLPIFIGGVAqgLTFPLLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFF--GIGWSYIGW 378
Cdd:cd17374 253 QEMQTLRTVLAVLGKGSSA--AAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMllGVYSPLLPM 323
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
43-399 |
5.48e-07 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 51.05 E-value: 5.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 43 PILPKLGAVFHQ---DAAGVALLITCFTLPSAFMTPVAGVLADRFG-RKAVLLPGLLLFACGGMGCAF-SDSFENLLAWR 117
Cdd:cd17335 15 SLLPFLSVYLKQlglSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFvAQIFWLLLLLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 118 AIQGLGAAPLGILYGTLV----GDFYKEADRPKVMGmvgaTISFGTALY---PAIGGFLGEMDWRWPFWI-SLAALPVGL 189
Cdd:cd17335 95 ILGAFFSAPVVPLVDSITlqylGEERERYGKQRLWG----SIGFGIAALlvgILIDRSSTYKNYTIAFYVfAVLMLLALL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 190 LALSVPLERPHTGMDWKqyaRDSRSIIFHSAAIGLFGLTFLCFCILYGPTITY-FPLLADLlyKATPSHIGAVFTVASLG 268
Cdd:cd17335 171 LALKFPFRPKHPEPNEN---TGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFlFWHLQDL--GGSKTLIGLLWTVGVVS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 269 TAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVLPDavsslWWLTLPIFIGgvaQGLTFPLLNARMTT----LAPT 344
Cdd:cd17335 246 EIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLEN-----PWLVLPIELL---HGLTFALVWAAAVSyasaAAPP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 491167012 345 RNRAIVMAM-NGTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGIGVALVIGALVWRV 399
Cdd:cd17335 318 GLRATAQGLlQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLI 373
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
75-192 |
7.44e-07 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 50.79 E-value: 7.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 75 PVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGAT 154
Cdd:PRK10473 56 LFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGI 135
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 491167012 155 ISFGTALYPAIGGF-LGEMDWRWPFW-ISLAALPVGLLAL 192
Cdd:PRK10473 136 TCIIPVLAPVLGHLiMLKFPWQSLFYtMAAMGILVLLLSL 175
|
|
| 2A0112 |
TIGR00891 |
putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic ... |
44-182 |
7.49e-07 |
|
putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273324 [Multi-domain] Cd Length: 405 Bit Score: 51.04 E-value: 7.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 44 ILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLG 123
Cdd:TIGR00891 34 VLAEVAGEFGLTTVDAASLISAALISRWFGALMFGLWGDRYGRRLPMVTSIVLFSAGTLACGFAPGYITMFIARLVIGIG 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491167012 124 AAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTAL----YPAIGGFLGeMDWRWPFWISL 182
Cdd:TIGR00891 114 MGGEYGSSAAYVIESWPKHLRNKASGLLISGYAVGAVVaaqvYSLVVPVWG-DGWRALFFISI 175
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
24-194 |
8.70e-07 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 50.77 E-value: 8.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVlCVAL-MGVMGVSITLPILPKLgavFHQDAAgVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGM 102
Cdd:cd17383 1 LVIV-CIALlLDNMLYMVIVPIIPDY---LNEDIA-IGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 103 GCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGD-FYKEADRPKVMGMVGATISFGTALYPAIGGFLGEM-DWRWPFWI 180
Cdd:cd17383 76 VFAFGESYAVLFFARSLQGVGSAFADTAGLAMIADrFTEEAERSKALGIALAFISFGCLVAPPFGGILYEFaGKEVPFLI 155
|
170
....*....|....*
gi 491167012 181 -SLAALPVGLLALSV 194
Cdd:cd17383 156 lAFVCLLDGLLLLLV 170
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
43-397 |
1.06e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 50.23 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 43 PILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFG-RKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQG 121
Cdd:cd17370 20 SILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILER 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 122 LGAAPLGILYGTLVGDFYKEADRPKV------MGMVGATISfgtALYPAIGGFLGEMDWRWPFWISL--AALPVGLLALS 193
Cdd:cd17370 100 LGKGIRTPPRDALLADATPPSGRGKAfglhraLDTLGAVLG---PLLAALLLYLLGGNYRTIFLLAAipALLALLILLFV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 194 VPL----ERPHTGMDWKQYARDSRSIIFHSAAIGLFGLTFLCFCilygptityFPLLADLLYKATPSHIGAVFTVASLGT 269
Cdd:cd17370 177 VKEyprpPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFA---------FLILRAQELGLSAALIPLLYALFNLVY 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 270 AAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVLpdavSSLWWLTLPIFIGGVAQGLTFPLLNARMTTLAPTRNRAI 349
Cdd:cd17370 248 ALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALG----SSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGT 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 491167012 350 VMAMNGTVLRLSQSLSPLFFGIGWSYIGWrgPYAMGIGVALVIGALVW 397
Cdd:cd17370 324 AYGLFNTVVGIGWLLASLIAGYLWDLISP--SAAFLFSAVLALIALLL 369
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
7-192 |
1.11e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 50.23 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 7 PGEASQEGQSRPVSLAGLVLVLCVALMGVMGVSITLPILpkLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGR 86
Cdd:cd17370 186 LRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLIL--RAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGR 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 87 KAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIG 166
Cdd:cd17370 264 KKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIA 343
|
170 180
....*....|....*....|....*..
gi 491167012 167 GFLGE-MDWRWPFWISLAALPVGLLAL 192
Cdd:cd17370 344 GYLWDlISPSAAFLFSAVLALIALLLL 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
24-170 |
1.33e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.29 E-value: 1.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVALMGVMGVSITLPILPKLGA-VFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGM 102
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYYFKyVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491167012 103 GCAFSDSfENLLAWRAIQGLGAAPLGILYGTL------VGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLG 170
Cdd:COG2211 310 LLFFLGP-GNLWLLLVLAALAGIGLGAILVLPwamladVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALA 382
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
43-396 |
2.03e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 49.54 E-value: 2.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 43 PILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGL 122
Cdd:cd17475 17 ALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 123 GAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTAL----YPAIGGFLGemdWRWPFWIS-----LAALPVGLL--- 190
Cdd:cd17475 97 GYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALaaalLPPLALHYG---WRAAFVVAglvsiLAAVLFWLFyre 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 191 ALSVPLERPHTGMDWKQYARDSRSIIFHSAAIGLFGLTFLCFCILygptiTYFPLLADLLYKATPSHIGAVFTVASLGTA 270
Cdd:cd17475 174 PPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALL-----TFLLLFLHDHLGLSVVAAGALLAVAQLGGA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 271 AIAMNLAWLGRKY--SHRRLMLSATCCYVVAQTLMLVLPDAVSSLWWLTLPIFIGGVAQGLTFPLLNARMTTLAPTRNRA 348
Cdd:cd17475 249 LGRIGLGRVSDRVfgGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAG 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 491167012 349 IVMAMNGTVLRLSQSLSPLFFGigwSYIGWRGPYAMG---IGVALVIGALV 396
Cdd:cd17475 329 TALGLANTINFIGIAIGPPLFG---LLVDATHSYAPAwlaLALLLVLAALL 376
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
20-194 |
3.76e-06 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 48.90 E-value: 3.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 20 SLAGLVLVLCVALMGVMGVSITLP-ILPKLGAVFHQdaagvALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFA 98
Cdd:pfam06609 45 SFAAFSLNVCATYFVLQASASALPnILQDIGQSENQ-----GLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 99 CGGM-GCAfSDSFENLLAWRAIQGLGAAPLG---ILYGTLVgdfykeADRPKVMGMVgaTISFGTALYPAIGGFLGEM-- 172
Cdd:pfam06609 120 VGAIvGCT-ANKFNTLLAAMTLLGVAAGPAGaspLFIGELM------SNKTKFLGLL--IVSAPTIAMNGAGPYFGQRla 190
|
170 180
....*....|....*....|....*
gi 491167012 173 ---DWRWPFWISLAALPVGLLALSV 194
Cdd:pfam06609 191 iqgNWRWIFYIYIIMSAIAVLLIII 215
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
53-395 |
5.39e-06 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 48.59 E-value: 5.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 53 HQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAI-----QGLGAAPL 127
Cdd:pfam05977 41 SASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTLLTLLAGLGLLSPWLLLgltflGGIGTALM 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 128 GILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLgeMDWRWPFW------ISLAALPVGLL-------ALSV 194
Cdd:pfam05977 121 DPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVL--LAAFGPAFtfalnaLSYFAVIAALWrwkraapASPL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 195 PLERPHT----GMDWKQYARDSRSIIFHSAAIGLFGLTFLCFcilygptityFPLLADLLYKATPSHIGAVFTVASLGTA 270
Cdd:pfam05977 199 PRERIFGavraGLRFTAMSRELRSVLVRAFAFGLSASAVWAL----------LPLVARDLLDGDAIFYGILLGAVGVGAI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 271 AIAMNLAWLGRKYSHRRLMLSATccyVVAQTLMLVLpdAVSSLWWLTLPIFI-GGVAQGLTFPLLNARMTTLAPTRNRAI 349
Cdd:pfam05977 269 LGALSLPRLRERLGSDRLVLLAS---VVTALVLLSL--ALAPNLWLAIPVLLlGGAAWITALTTLNVAVQLSVPRWVRGR 343
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 491167012 350 VMAMNGTVLRLSQSLSplffGIGWSYIGwrgpYAMGIGVALVIGAL 395
Cdd:pfam05977 344 ALAVYQTVFFGGMAAG----SWLWGAVA----EALSVTGALLGAAA 381
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-163 |
8.34e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.41 E-value: 8.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMG 103
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491167012 104 CAFSDSFENLLAWR---AIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYP 163
Cdd:pfam07690 282 LLLLSLTLSSLWLLlalLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
76-176 |
1.14e-05 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 46.96 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 76 VAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATI 155
Cdd:cd17379 52 VIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVGIVYQMFF 131
|
90 100
....*....|....*....|.
gi 491167012 156 SFGTALYPAIGGFLGEmdWRW 176
Cdd:cd17379 132 TLGLLILPGIAYFIPH--WRW 150
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
24-396 |
2.13e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 46.44 E-value: 2.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMG 103
Cdd:cd17331 2 LLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 104 CAFSDSFENLLAWR----AIQGLGAAPlgilygTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGE-MDWRWPF 178
Cdd:cd17331 82 LAFASSVPMLFLSRlpsvFMHAMQAAQ------MVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKkFGEQAAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 179 WISLAALPVGLLALSVPLERPHTGMDWKQYARDSRSI-IFHSAAIGLF----GLTFLCFCILYGPTIT-----YFPLLAD 248
Cdd:cd17331 156 LVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPPsVFNLKEILRLlrlpGVAFLLLVKLLSGLPIgmfqsMFSLVAM 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 249 LLYKATPSHIGAVFT-VASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVlpdaVSSLWWLTLPIFIGGVAQ 327
Cdd:cd17331 236 DFFGLTPEENGYLMSyAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAF----VTTVWQLLVLLLPLVIGG 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 328 GLTFPLLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRG-PYAMGIGVALVIGALV 396
Cdd:cd17331 312 SVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSfGLLGAAINGLLTVYLL 381
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
52-180 |
4.56e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 45.24 E-value: 4.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 52 FHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENL-LAWRAIQGLGaapLGIL 130
Cdd:cd17352 33 FGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLyLTYGVLGGLG---LGLI 109
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 491167012 131 Y--GTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFL-GEMDWRWPFWI 180
Cdd:cd17352 110 YspAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLlDNYGWRGALLI 162
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
67-195 |
4.63e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 45.34 E-value: 4.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 67 TLPSAFmtpVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLG---AAPLGIlygTLVGDFYKEAD 143
Cdd:PRK11551 63 LLPGAL---LGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGlggALPNLI---ALTSEAVGPRL 136
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 491167012 144 RPKVMGMVGATISFGTALYPAIGGFLGE-MDWRWPFWISLAA--LPVGLLALSVP 195
Cdd:PRK11551 137 RGTAVSLMYCGVPFGGALASVIGVLAAGdAAWRHIFYVGGVGplLLVPLLMRWLP 191
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
228-404 |
8.55e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.51 E-value: 8.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 228 TFLCFCILYGPTITYFPLLADLLykATPSHIGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVlp 307
Cdd:cd17489 5 NFFFFLSFYLLLPVLPLYAHDLG--GSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 308 daVSSLWWLTLPIFIGGVAQGLTFPLLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGIG 387
Cdd:cd17489 81 --ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAV 158
|
170
....*....|....*..
gi 491167012 388 VALVIGALVWRVYPVSS 404
Cdd:cd17489 159 LALLALLLVFLVKDPPP 175
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
254-407 |
9.61e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.08 E-value: 9.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 254 TPSHIGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVLPdavsSLWWLTLPIFIGGVAQGLTFPL 333
Cdd:cd17324 32 SVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP----SFALLLLARALAGLAHGGFWAI 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491167012 334 LNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGIGVALVIGALVWRVYPVSSGKE 407
Cdd:cd17324 108 AAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
43-392 |
1.02e-04 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 43 PILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFeNLLAWRAIQGL 122
Cdd:cd17339 20 PLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIA-LLFLGTALAGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 123 GAAPLGILYGTLVGDfYKEADRPKVMGMVGATISFGTALYPAIGGFL-GEMDWRWPFWISLAALPVGLLALS-VPLERPH 200
Cdd:cd17339 99 GIAVGNVLLPSLIKR-DFPRRVGLMTGLYTTSMNLGAALASGLSVPLaQALGGGWRGALAIWALPALLALLIwLPQLRRR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 201 TGMDWKQYARDSRSIIFHSAAIGL---FGLTFLCFCILygptITYFP-LLADllYKATPSHIGAVFTVASLGTAAIAMNL 276
Cdd:cd17339 178 KRAAAAAAPLTKISVWRSPLAWQVtlfMGLQSLLFYTL----MAWLPtILID--AGLSAATAGWLLSLFQLVGIPASLLV 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 277 AWLGRKYSHRRLMLSATC-CYVVAQTLMLVLPDAVSSLWWLTLpifigGVAQGLTFPLLNARMTTLAPT-RNRAIVMAMN 354
Cdd:cd17339 252 PILATRLKNQRPIVVLLAvLFIIGVLGLLFAPTALALLWAVLL-----GLGGGAAFSLALTLISLRSSDpAEAAALSGMA 326
|
330 340 350
....*....|....*....|....*....|....*....
gi 491167012 355 GTVLRLSQSLSPLFFGIGWSYIG-WRGPYAMGIGVALVI 392
Cdd:cd17339 327 QSVGYLLAALGPLLFGVLHDLTGsWTAPLVLLLALTVLQ 365
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
24-192 |
1.06e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.95 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 24 LVLVLCVALMGVMGVSITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADR-FGRKAVLLPGLLLFACGGM 102
Cdd:cd06174 206 WLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLA 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 103 GCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGEM--DWRWPFWI 180
Cdd:cd06174 286 LLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtfGLTGAFLV 365
|
170
....*....|..
gi 491167012 181 SLAALPVGLLAL 192
Cdd:cd06174 366 LAVLLLLAAILL 377
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
28-125 |
1.55e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 43.92 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 28 LCVALMGVMGVSITLpILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFS 107
Cdd:PRK03893 27 LGYLLDGFDFVLITL-VLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFA 105
|
90
....*....|....*...
gi 491167012 108 DSFENLLAWRAIQGLGAA 125
Cdd:PRK03893 106 PGYWTLFIARLVIGMGMA 123
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
253-394 |
1.69e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 43.33 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 253 ATPSHIGAVFTVASLgTAAIAMNL-AWLGRKYSHRRLMLSATCCYVVAQTLMLVLPdavsSLWWLTLPIFIGGVAQGLTF 331
Cdd:cd17503 28 ASLDTVQWVITSYLL-ALAIMIPLsGWLADRFGTRRLFLTALALFTLGSLLCGLAP----NLASLIIFRILQGFGGGVLI 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491167012 332 PLLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPY--AMGIGVALVIGA 394
Cdd:cd17503 103 PLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFyiNLPIGILALLLA 167
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
52-397 |
2.85e-04 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 42.62 E-value: 2.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 52 FHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLG-IL 130
Cdd:PRK15402 43 FNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGaVG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 131 YGTLVGDFyKEADRPKVMGMVGATISFGTALYPAIGGFLGEM-DWRWPFWI--SLAALP-VGL-LALSVPLERPHTGMDW 205
Cdd:PRK15402 123 YAAIQESF-EEADAIKITALMANVALLAPLLGPLVGAALIHVlPWRGMFVLfaALAALSfFGLwRAMPETAGRVGEKLSL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 206 KQYARDSRSIIFH------SAAIGLFGLTFLCFcILYGPTItyfpLLADLlyKATPSHIG----AVFtvaslgTAAIAMN 275
Cdd:PRK15402 202 KELGRDYKLVLKNrrfvagALALGLVSLPLLAW-IALSPVI----LISGE--QLSSYEYGllqvPVF------GALIAGN 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 276 --LAWLGRKYSHRRLMLSATCCYVVAQTLMLVLPDAVSSLW-WLTLPIFIGGVAQGLTFPLLNaRMTTLAPTRNRAIVMA 352
Cdd:PRK15402 269 ltLARLTSRRPLRSLIRMGLWPMVAGLLLAALATVISSHAYlWLTAGLSLYAFGIGLANAGLY-RLTLFSSDVSKGTVSA 347
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 491167012 353 MNGTVLRLSqslspLFFGIGWSYIGWRGPYAMGIGVALVIGALVW 397
Cdd:PRK15402 348 AMGMLSMLI-----FTVGIELSKHAYLGGGNGLFNLFNLANGLLW 387
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
52-347 |
4.22e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 42.13 E-value: 4.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 52 FHQDAAGVALLITCFTLPSAFMT-PVAGVLA----DRFGRKAVLLPGLLLFACGGMGCAFSDSFEN--------LLAWRA 118
Cdd:cd17369 34 FPAVDPAAGTLAAFATFGVGFLArPLGGVVFghfgDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQigilapilLVLLRL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 119 IQGLGaapLGILYG--TLVGDFYKEADRPKVMGM---VGATISF--GTALYPAIGGFLGEMD-----WRWPFWISLAALP 186
Cdd:cd17369 114 LQGLA---LGGEWGgaVLMAVEHAPPKRRGFYGSfpqLGAPVGLllATGVFLLLSALLSDEAflswgWRIPFLLSAVLVA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 187 VGL--------------LALSVPLERPHTGMDWKQYARDSRSIIFHSAAIGLFGLTFLCFCILYGPTITYFPLLADLLYK 252
Cdd:cd17369 191 VGLyirlrleetpvfrrAKEAGQVVRAPLVEVLRRHWRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAV 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 253 ATPSHIGAVFTVASlgtaaiamnlAWLGRKYSHRRLMLSATCCYVVAQTLMLVLPDAVSSLWWLTLPIFIGGVAQGLTFP 332
Cdd:cd17369 271 LIASVVAAITIPLF----------GWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYG 340
|
330
....*....|....*
gi 491167012 333 LLNARMTTLAPTRNR 347
Cdd:cd17369 341 PQAAFLAELFPTRVR 355
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
44-136 |
4.42e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.21 E-value: 4.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 44 ILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFenLLAWRAIQGLG 123
Cdd:cd17353 25 FNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISL--PLLFLGYGVLG 102
|
90
....*....|...
gi 491167012 124 AAPLGILYGTLVG 136
Cdd:cd17353 103 GIGAGIGYITPVS 115
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
55-201 |
4.63e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 41.98 E-value: 4.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 55 DAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTL 134
Cdd:TIGR00881 28 SKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRT 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 135 VGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLGEM--DWRWPFWIS-LAALPVGLLALSVPLERPHT 201
Cdd:TIGR00881 108 VTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAElySWHWVFIVPgIIAIIVSLICFLLLRDSPQS 177
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
253-397 |
5.48e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.77 E-value: 5.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 253 ATPSHIGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVLPdavsSLWWLTLPIFIGGVAQGLTFP 332
Cdd:cd17321 28 ASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP----SLAFLIAARALQGIGAAAIMP 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491167012 333 LLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRgpYAMGIGVALVIGALVW 397
Cdd:cd17321 104 ASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWR--WIFLINVPIGLVALLL 166
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
62-299 |
6.07e-04 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 41.49 E-value: 6.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 62 LITCFTLPSAFMTP-VAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGaapLGILYGTlVGDFYK 140
Cdd:cd17360 39 LIVSSTVAGAAVGAaIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLG---VGIASMT-VPLYIA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 141 EADRPKVMGMVGAT----ISFGTALYPAIGGFLGEMDWRWPFWISLAALP-----VGLLALSVPLERPHTgmdwkqyard 211
Cdd:cd17360 115 EAAPPRIRGRLVTInvlfITGGQFVAYVINGAFSYLPGGWRWMLGLAAVPavlqfIGLLFLPESPRWPST---------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 212 srsiiFHSAAIGLFGLTFLCFC-----ILYGPTITYFPLLAD----LLYKATPSHIGAVFTVASLgtaaiamnlaWLGRK 282
Cdd:cd17360 185 -----RRALIVGCGLQAFQQFSgintvMYYSATILQMAGFKDnqnaIWLSLIVAGTNFIFTIVGM----------YLIDK 249
|
250
....*....|....*..
gi 491167012 283 YSHRRLMLSATCCYVVA 299
Cdd:cd17360 250 FGRRKLLLISLFGVIVA 266
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
61-193 |
7.86e-04 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 41.49 E-value: 7.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 61 LLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGL--GAAPLGIlygTLVGDF 138
Cdd:cd17389 68 LIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGIskGNVSLST---AIVADV 144
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 491167012 139 YKEADRPKVMGMVGATISFGTALYPAIGGFLGEMDWRWPF-WISLAALPVGLLALS 193
Cdd:cd17389 145 TSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTRSLGEvFFSMPALFALVLALA 200
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
76-176 |
1.10e-03 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 40.86 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 76 VAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATI 155
Cdd:cd17446 52 VFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAVVGTLLGYCY 131
|
90 100
....*....|....*....|.
gi 491167012 156 SFGTALYPAIGGFLgeMDWRW 176
Cdd:cd17446 132 TLGQLILAGVAYAI--RDWRW 150
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
21-200 |
1.14e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 41.02 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 21 LAGLVLVLCVALMGvMGVSITLPILPKL----GAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLL 96
Cdd:cd17358 2 LATFVANLGSFSFG-IAVGWSSPALPSLmsdnSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 97 FACGGMGCAFSDSFENLLAWRAIQGLGAaplGILYGTlVGDFYKEADRPKVMGMVGAT----ISFGTALYPAIGGFLgem 172
Cdd:cd17358 81 CILGWLLIAFAKDVWMLYLGRFLAGFGG---GAASVV-VPVYIAEIAPKNVRGALGSLnqllVNIGILLGYVLGSFL--- 153
|
170 180
....*....|....*....|....*...
gi 491167012 173 DWRWPFWISLAALPVGLLALSVPLERPH 200
Cdd:cd17358 154 PWRTLALIGAIPPVVFLILLFFIPESPR 181
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
50-189 |
1.19e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 40.82 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 50 AVFHQDAAGVALLITCFTL-PSAFMTPVAGVL----ADRFGRKAVLLPGLLLFACGGMGCAFSDSFEN--------LLAW 116
Cdd:cd17368 28 LFFPSGSEFASLLLTFATFgVGFFMRPIGAIVlgayADRIGRKPAMTLTLAIMALGTLLIALAPTYATigiaapllVLLA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 117 RAIQGLGAaplGILYGTlVGDFYKEADRPKVMGMVGATISFGTALYPAIGGFLG-------------EMDWRWPFWISLA 183
Cdd:cd17368 108 RLLQGFAA---GGEVGG-VTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGyllsltltaealaEWGWRIPFFIGLL 183
|
....*.
gi 491167012 184 ALPVGL 189
Cdd:cd17368 184 IIPLGL 189
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
76-195 |
1.30e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 40.72 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 76 VAGVLADRFGRKAVLLPGLLLFACGGMGCAFSD---SFENLLAWRAIQGLGA------APLGI-------LYGTLVGDFy 139
Cdd:pfam00083 65 FAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVggasvlAPMYIseiapkkLRGALGSLY- 143
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 491167012 140 keaDRPKVMG-MVGATISFGTALYPAIGGflgemdWRWPFWISLA-ALPVGLLALSVP 195
Cdd:pfam00083 144 ---QLAITFGiLLAYIFGLGLNKTSNSDG------WRIPLGLQLVpALLLIIGLLFLP 192
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
55-372 |
1.35e-03 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 40.69 E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 55 DAAGVALLITCFTLPSAFMTPVAGVLADRFG-RKAVLLPGLLLFAC---GGMGCAFSDSFENLLAWRAIQGLGAAPLGIL 130
Cdd:pfam12832 32 NPSEIGLITAILPLTRILAPPIWGWLADRTGkRKAVVRLASILAAVlflSVLFIPISLTFWWLALLVVLFSFFWNAILPQ 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 131 YGTLV----GDFYKEADRPKVMGMVG-ATISFGTAlyPAIGGFLGEMDWRWPFWISLAALpvgLLALSVPLERPHTGMDW 205
Cdd:pfam12832 112 FEVATlqhlGEKRKDYGRQRLWGSVGfALSVFGLG--ALFDHYSVGLLPSVLFYLFAALM---LLSLLLPLAPPEMEYES 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 206 KQYARDSR-SIIFHSAAIGLFGLTFLCfCILYGPTITYFPLLADLLyKATPSHIGAVFTVASLGTAAIAMNLAWLGRKYS 284
Cdd:pfam12832 187 KGGSKAVFwNLLKQPEVIIFFLAAFLL-GFSHGPFYTFLFLYLENL-GASNTLLGALWALGVVAEIPLFFYAHRLLRRFG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 285 HRRLMLSAtccyVVAQTLMLVLPDAVSSLWWLTLPI-FIGGVAQGLTFPLLNARMTTLAPTRNRAIVMAMngtvlrlsqs 363
Cdd:pfam12832 265 HRNLLIIA----LLLTALRWLLYAFFVENPWLVLPIqFLHAISFGLTHAAAIEYVRRIFPGSLQGTGQAL---------- 330
|
....*....
gi 491167012 364 LSPLFFGIG 372
Cdd:pfam12832 331 YSGLYFGLG 339
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
76-199 |
1.63e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 40.33 E-value: 1.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 76 VAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSF-ENLLAWRAI---QGLGAAPLgilyGTLVGDFYKEADRPKVMGMV 151
Cdd:cd17312 57 ISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLwFFAVLWGLNglfQSMGWPPC----VKLLGNWFSKKERGTVYGIW 132
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 491167012 152 GATISFGTALYPAIGGFL-GEMDWRWPFWIS-LAALPVGLLALSVPLERP 199
Cdd:cd17312 133 STSHNFGGILAPILAASLaSYYGWRAAFLVPgIVGLVVAIILFFFLRDSP 182
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
61-401 |
2.62e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 39.48 E-value: 2.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 61 LLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAplgiLYGTLVGDFYK 140
Cdd:cd17315 38 LVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVG----LASVLVPLYIS 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 141 EADRPKVMGMVGA----TISFGTALYPAIGGFLGEMD-WRWPFWISLAALPVGLLALSVPlerphtgmdwkqYARDSRSI 215
Cdd:cd17315 114 EIAPAKIRGALGTlnqlMITFGILLAYLLGLALSLSPpGWWRLMFALAAVPALLQLLLMF------------FLPESRAL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 216 IFhsaAIGLFGLTFLC---FCILYGPTItyfplLADLLYKATPSHIGAVFTVASLGTAAIAMnlaWLGRKYSHRRLMLSA 292
Cdd:cd17315 182 LV---GVGLQLLQQLTginAVMYYAPTI-----FKSAGGGTASILASIIVGVVNLLATLVAI---RLVDKVGRRPLLLIG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 293 ----TCCYVVAQTLMLVLPDAVSSLWW--LTLPIFIGGVAQGLTfPLLNARMTTLAPTRNRAIVMAMNGTVLRLSQSLSP 366
Cdd:cd17315 251 fagmAASLLLLAIAFLLPALAKAAGWLalLGILLYIAAFAMGAG-PVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVG 329
|
330 340 350
....*....|....*....|....*....|....*
gi 491167012 367 LFFGIGWSYIGWRGPYAMGIGVALVIGALVWRVYP 401
Cdd:cd17315 330 LTFLIMVSTIGLAGVFIFFAAVCLLALVFVFFFVP 364
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
78-242 |
3.20e-03 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 39.42 E-value: 3.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 78 GVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATISF 157
Cdd:PRK15403 72 GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLV 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 158 GTALYPAIG-GFLGEMDWRWPFWI----SLAALPVGLLALSVPLERPHTGMDWKQYARDSRSIIFHSaaIGLFGLTFLCF 232
Cdd:PRK15403 152 APIIGPLSGaALMHFVHWKVLFAIiavmGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFRNR--LFLTGAATLSL 229
|
170
....*....|
gi 491167012 233 CilYGPTITY 242
Cdd:PRK15403 230 S--YIPMMSW 237
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
25-112 |
3.67e-03 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 39.13 E-value: 3.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 25 VLVLCVALMGVMGVsITLPILPKLGAVFHQDAAGVALLITCFTLPSAFMTPVAGVLADRFGRKAVLLPGLLLFACGGMGC 104
Cdd:cd17394 3 LVTSLFFLWGFATN-LNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALLF 81
|
....*...
gi 491167012 105 AFSDSFEN 112
Cdd:cd17394 82 IPAASLRT 89
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
258-401 |
3.74e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 39.09 E-value: 3.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 258 IGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVVAQTLMLVLPdavsSLWWLTLPIFIGGVAQGLTFPLLNAR 337
Cdd:COG2807 55 AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP----SVALLLAGTALIGAGIAVGNVLLPGL 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491167012 338 MTTLAPTRnRAIVMAMNGTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGIGVALVIGALVWRVYP 401
Cdd:COG2807 131 IKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLR 193
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
76-396 |
5.94e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 38.44 E-value: 5.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 76 VAGVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRPKVMGMVGATI 155
Cdd:cd06180 53 LASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGV 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 156 SFGTALYPAIGGFLGEMDWRW-PFWISLAALPVGLLALSVPLERPHTGMDWKQYARDSRSiiFHSAAIGLFGLTFLCFCI 234
Cdd:cd06180 133 GLGIALSGLLVPAGLGGGLSWrAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAAESAP--GLNRPLWRLALAYGLFGF 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 235 LYGPTITYFPLLADllyKATPSHIGAVFTVASLGTAAIAMNLAWLGRKYSHRRLMLSATCCYVvaQTLMLVLPDAVSSLW 314
Cdd:cd06180 211 GYIITATFLPLIAR---ETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLV--QAVGVLLPLLSPGPA 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 315 WLTLPIFIGGVAQGLTFPLLNARMTTLAPTRNRAIVMAMNgTVLRLSQSLSPLFFGIGWSYIGWRGPYAMGIGVALVIGA 394
Cdd:cd06180 286 GLVLSAVLFGGTFMAITALVMALARELAPPAAPRALALMT-ASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAA 364
|
..
gi 491167012 395 LV 396
Cdd:cd06180 365 LL 366
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
78-176 |
7.15e-03 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 38.17 E-value: 7.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 78 GVLADRFGRKAVLLPGLLLFACGGMGCAFSDSFENLLAWRAIQGLGAAPLGILYGTLVGDFYKEADRpKVMGMVGATI-S 156
Cdd:cd17447 56 GYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHR-TVAGVLISLFwT 134
|
90 100
....*....|....*....|
gi 491167012 157 FGTALYPAIGGFLgeMDWRW 176
Cdd:cd17447 135 VGNMLLALVAYLI--RDWRW 152
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
21-396 |
9.56e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 38.37 E-value: 9.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 21 LAGLVLVLCVALMGVMgVSITLPILPKLGAVFHQDAAGVALLITC----FTLPSAFMTPVAGVLADRFGRKAVL----LP 92
Cdd:PRK08633 8 IIGFLPLLLTQFLNAF-NDLGHKILIQNTLIKAYDGSEQVILTAIvnalFLLPFLLLSSPAGFLADKFSKNRVIrivkLF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 93 GLLLFACGGMGCAFSdSFENLLAWRAIQGLGAAPLG-ILYGtLVGDFYKEADRPKVMGMVGAT----ISFGTALYPAIGG 167
Cdd:PRK08633 87 EVGLTLLIVLAYYLG-WFWLAFAVTFLLGAQSAIYSpAKYG-IIPELVGKENLSRANGLLEAFtivaILAGTALFSFLFE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 168 FLGEMDwRWPFWISLAALPVGLLALSV-------PLER-PHT---GMDWKQYA-----RDSRSIIFHSAAIGLfgltflc 231
Cdd:PRK08633 165 SVNGNT-PSEILGRIAPAGLVLLAVAVlglifayRLPKvPAAapeVFDKKKYLfpkllWRNLKLLRSDRVLWL------- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 232 fCILygpTITYFPLLADLLYKATPSH------------IGAVFTVASLGtaaIAMNLAWLGRkYSHRRLMLSATCCYVVA 299
Cdd:PRK08633 237 -AII---GLSYFWFISQLAQANFPAYakevlgldntfqVQYLLAASAIG---IGIGSLLAGR-LSGRHIELGLVPLGALG 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491167012 300 QTLMLVLPDAVSSLWWLTLPIFIGGVAQGLTFPLLNARMTTLAPTRNRAIVMAMNGTVlrlsQSLSPLFF---GIGWSYI 376
Cdd:PRK08633 309 LALSLFLLPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGKVLAANNFL----QNVGMLLFlalTTLFSGL 384
|
410 420
....*....|....*....|.
gi 491167012 377 GWRGPYAM-GIGVALVIGALV 396
Cdd:PRK08633 385 GLSPAGLFyLIALVTLIGTLY 405
|
|
| |
