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Conserved domains on  [gi|492834075|ref|WP_005988029|]
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GNAT family N-acetyltransferase [Xanthomonas vesicatoria]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11441181)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
11-164 3.22e-59

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


:

Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 181.73  E-value: 3.22e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834075  11 HASAILDIFNEAIANSTALYDYRPRLPESMVGWFAAKRAGGFPVIgVEDADGTLMGFASYGTFRAWPAFKYSVEHAIYVH 90
Cdd:COG1247   11 DAPAIAAIYNEAIAEGTATFETEPPSEEEREAWFAAILAPGRPVL-VAEEDGEVVGFASLGPFRPRPAYRGTAEESIYVD 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492834075  91 QDHRGKGLGRVLLQALIAAAEERGVHVLVGGIDASNQASIALHQQFGFTHAGTVREAGFKFGRWLDLAFYQRIL 164
Cdd:COG1247   90 PDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTLPEVGFKFGRWLDLVLMQKRL 163
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
11-164 3.22e-59

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 181.73  E-value: 3.22e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834075  11 HASAILDIFNEAIANSTALYDYRPRLPESMVGWFAAKRAGGFPVIgVEDADGTLMGFASYGTFRAWPAFKYSVEHAIYVH 90
Cdd:COG1247   11 DAPAIAAIYNEAIAEGTATFETEPPSEEEREAWFAAILAPGRPVL-VAEEDGEVVGFASLGPFRPRPAYRGTAEESIYVD 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492834075  91 QDHRGKGLGRVLLQALIAAAEERGVHVLVGGIDASNQASIALHQQFGFTHAGTVREAGFKFGRWLDLAFYQRIL 164
Cdd:COG1247   90 PDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTLPEVGFKFGRWLDLVLMQKRL 163
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 21-138 1.58e-17

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 73.71  E-value: 1.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834075   21 EAIANSTALYDYRPRLPESMVGWFAAKRAGGFPVIGVEDaDGTLMGFASYgtFRAWPAFKYSVEHAIYVHQDHRGKGLGR 100
Cdd:pfam00583   2 EALYELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEE-DGELVGFASL--SIIDDEPPVGEIEGLAVAPEYRGKGIGT 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 492834075  101 VLLQALIAAAEERGVHVLVGGIDASNQASIALHQQFGF 138
Cdd:pfam00583  79 ALLQALLEWARERGCERIFLEVAADNLAAIALYEKLGF 116
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 87-145 4.82e-12

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 60.33  E-value: 4.82e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 492834075  87 IYVHQDHRGKGLGRVLLQALIAAAEERGVHVLVGGIDASNQASIALHQQFGFTHAgTVR 145
Cdd:PRK09491  69 IAVDPDYQRQGLGRALLEHLIDELEKRGVATLWLEVRASNAAAIALYESLGFNEV-TIR 126
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 57-145 4.11e-09

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 51.95  E-value: 4.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834075   57 VEDADGTLMGFASYGTfrawPAFKYSVeHAIYVHQDHRGKGLGRVLLQALIAAAEERGVHVLVGGIDASNQASIALHQQF 136
Cdd:TIGR01575  35 LARIGGKVVGYAGVQI----VLDEAHI-LNIAVKPEYQGQGIGRALLRELIDEAKGRGVNEIFLEVRVSNIAAQALYKKL 109


                  ....*....
gi 492834075  137 GFTHAGTVR 145
Cdd:TIGR01575 110 GFNEIAIRR 118
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 61-119 1.00e-07

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 46.89  E-value: 1.00e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 492834075  61 DGTLMGFASYgtFRAWPAFKYSVEHAIYVHQDHRGKGLGRVLLQALIAAAEERGVHVLV 119
Cdd:cd04301    7 DGEIVGFASL--SPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLR 63
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
11-164 3.22e-59

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 181.73  E-value: 3.22e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834075  11 HASAILDIFNEAIANSTALYDYRPRLPESMVGWFAAKRAGGFPVIgVEDADGTLMGFASYGTFRAWPAFKYSVEHAIYVH 90
Cdd:COG1247   11 DAPAIAAIYNEAIAEGTATFETEPPSEEEREAWFAAILAPGRPVL-VAEEDGEVVGFASLGPFRPRPAYRGTAEESIYVD 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492834075  91 QDHRGKGLGRVLLQALIAAAEERGVHVLVGGIDASNQASIALHQQFGFTHAGTVREAGFKFGRWLDLAFYQRIL 164
Cdd:COG1247   90 PDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTLPEVGFKFGRWLDLVLMQKRL 163
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 11-163 1.58e-20

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 83.12  E-value: 1.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834075  11 HASAILDIFNEAiaNSTALYDYRPRLPESMVGWFAA-----KRAGGFPVIGVEDADGTLMGFASygtFRAWPAFKYSVEH 85
Cdd:COG1670   17 DAEALAELLNDP--EVARYLPGPPYSLEEARAWLERlladwADGGALPFAIEDKEDGELIGVVG---LYDIDRANRSAEI 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 492834075  86 AIYVHQDHRGKGLGRVLLQALIAAA-EERGVHVLVGGIDASNQASIALHQQFGFTHAGTVREAGFKFGRWLDLAFYQRI 163
Cdd:COG1670   92 GYWLAPAYWGKGYATEALRALLDYAfEELGLHRVEAEVDPDNTASIRVLEKLGFRLEGTLRDALVIDGRYRDHVLYSLL 170
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 21-138 1.58e-17

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 73.71  E-value: 1.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834075   21 EAIANSTALYDYRPRLPESMVGWFAAKRAGGFPVIGVEDaDGTLMGFASYgtFRAWPAFKYSVEHAIYVHQDHRGKGLGR 100
Cdd:pfam00583   2 EALYELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEE-DGELVGFASL--SIIDDEPPVGEIEGLAVAPEYRGKGIGT 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 492834075  101 VLLQALIAAAEERGVHVLVGGIDASNQASIALHQQFGF 138
Cdd:pfam00583  79 ALLQALLEWARERGCERIFLEVAADNLAAIALYEKLGF 116
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 85-146 3.86e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 61.60  E-value: 3.86e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492834075  85 HAIYVHQDHRGKGLGRVLLQALIAAAEERGVHVLVGGIDASNQASIALHQQFGFTHAGTVRE 146
Cdd:COG0456   17 EDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPN 78
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
86-150 2.10e-12

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 59.54  E-value: 2.10e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492834075  86 AIYVHQDHRGKGLGRVLLQALIAAAEERGVHVLVGGIDASNQASIALHQQFGFTHAGTVREAGFK 150
Cdd:COG3393   20 GVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYERLGFRPVGEYATVLFR 84
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 87-145 4.82e-12

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 60.33  E-value: 4.82e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 492834075  87 IYVHQDHRGKGLGRVLLQALIAAAEERGVHVLVGGIDASNQASIALHQQFGFTHAgTVR 145
Cdd:PRK09491  69 IAVDPDYQRQGLGRALLEHLIDELEKRGVATLWLEVRASNAAAIALYESLGFNEV-TIR 126
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
11-159 7.98e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 57.02  E-value: 7.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834075  11 HASAILDIFNEAianstalydYRPRLPESMVGWFAAKRAGGFPVIGVEDadGTLMGFASYGTFRAWPAFKYSVEHAIYVH 90
Cdd:COG3153    8 DAEAIAALLRAA---------FGPGREAELVDRLREDPAAGLSLVAEDD--GEIVGHVALSPVDIDGEGPALLLGPLAVD 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 492834075  91 QDHRGKGLGRVLLQALIAAAEERGVH--VLVGgidasNQASIALHQQFGFTHAGTVREAGFKFGRWLDLAF 159
Cdd:COG3153   77 PEYRGQGIGRALMRAALEAARERGARavVLLG-----DPSLLPFYERFGFRPAGELGLTLGPDEVFLAKEL 142
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 57-145 1.02e-10

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 56.60  E-value: 1.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834075  57 VEDADGTLMGFASYgtfrawpaFKYSVEHA----IYVHQDHRGKGLGRVLLQALIAAAEERGVHVLVGGIDASNQASIAL 132
Cdd:COG0454   38 AVDDKGEPIGFAGL--------RRLDDKVLelkrLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNPAAIRF 109

                         90
                 ....*....|...
gi 492834075 133 HQQFGFTHAGTVR 145
Cdd:COG0454  110 YERLGFKEIERYV 122
COG3818 COG3818
Predicted N-acetyltransferase, GNAT superfamily [General function prediction only];
87-148 2.00e-10

Predicted N-acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 443030 [Multi-domain]  Cd Length: 168  Bit Score: 56.48  E-value: 2.00e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492834075  87 IYVHQDHRGKGLGRVLLQALIAAAEERGVHVLVGG--IDASNQASIALHQQFGFTHAGTVREAG 148
Cdd:COG3818   90 IVVAPSARGRGLGRALYADVFSYARARGVPRVTCEvnLEPPNPGSLAFHARLGFREVGQQRVAG 153
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 57-145 4.11e-09

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 51.95  E-value: 4.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834075   57 VEDADGTLMGFASYGTfrawPAFKYSVeHAIYVHQDHRGKGLGRVLLQALIAAAEERGVHVLVGGIDASNQASIALHQQF 136
Cdd:TIGR01575  35 LARIGGKVVGYAGVQI----VLDEAHI-LNIAVKPEYQGQGIGRALLRELIDEAKGRGVNEIFLEVRVSNIAAQALYKKL 109


                  ....*....
gi 492834075  137 GFTHAGTVR 145
Cdd:TIGR01575 110 GFNEIAIRR 118
Acetyltransf_4 pfam13420
Acetyltransferase (GNAT) domain;
43-156 6.36e-09

Acetyltransferase (GNAT) domain;


Pssm-ID: 433192 [Multi-domain]  Cd Length: 153  Bit Score: 51.98  E-value: 6.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834075   43 WFAAKRAGGFPVIGVEDADgTLMGFASYGTFRAWPAFKysVEHAIYVhQDHRGKGLGRVLLQALIAAAEER-GVHVLVGG 121
Cdd:pfam13420  40 FLAAYLSPGEIVFGVAESD-RLIGYATLRQFDYVKTHK--AELSFYV-VKNNDEGINRELINAIIQYARKNqNIENLEAC 115

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 492834075  122 IDASNQASIALHQQFGFTHAGTVREAGFKFGRWLD 156
Cdd:pfam13420 116 IASNNINAIVFLKAIGFEWLGIERNAIKKNGRWID 150
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 57-139 7.80e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 50.15  E-value: 7.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834075   57 VEDADGTLMGFASYGTFrawPAFKYSVEHAIYVHQDHRGKGLGRVLLQALIAAAEERGVHVLVggIDASNQAsIALHQQF 136
Cdd:pfam13508   7 VAEDDGKIVGFAALLPL---DDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLE--LETTNRA-AAFYEKL 80


                  ...
gi 492834075  137 GFT 139
Cdd:pfam13508  81 GFE 83
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 57-142 1.97e-08

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 50.38  E-value: 1.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834075  57 VEDADGTLMGFASYGTFRAWPAfkysvE-HAIYVHQDHRGKGLGRVLLQALIAAAEERGV-HVLVGgidaSNQASIALHQ 134
Cdd:COG1246   32 VAEEDGEIVGCAALHPLDEDLA-----ElRSLAVHPDYRGRGIGRRLLEALLAEARELGLkRLFLL----TTSAAIHFYE 102


                 ....*...
gi 492834075 135 QFGFTHAG 142
Cdd:COG1246  103 KLGFEEID 110
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
87-142 3.31e-08

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 49.80  E-value: 3.31e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 492834075  87 IYVHQDHRGKGLGRVLLQALIAAAEERGVHVLVggIDASNQAsIALHQQFGFTHAG 142
Cdd:COG2153   64 VAVLPEYRGQGLGRALMEAAIEEARERGARRIV--LSAQAHA-VGFYEKLGFVPVG 116
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 87-151 6.04e-08

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 48.81  E-value: 6.04e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 492834075   87 IYVHQDHRGKGLGRVLLQALIAAAEERGVHVLVGGIDASNQAsIALHQQFGFTHAGTVRE-AGFKF 151
Cdd:pfam13673  57 LFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTVNASPYA-VPFYEKLGFRATGPEQEfNGIRF 121
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 61-119 1.00e-07

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 46.89  E-value: 1.00e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 492834075  61 DGTLMGFASYgtFRAWPAFKYSVEHAIYVHQDHRGKGLGRVLLQALIAAAEERGVHVLV 119
Cdd:cd04301    7 DGEIVGFASL--SPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLR 63
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 86-139 1.04e-07

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 47.32  E-value: 1.04e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 492834075   86 AIYVHQDHRGKGLGRVLLQALIAAAEERGVHVLVgGIDASNQASIALHQQFGFT 139
Cdd:pfam08445  26 ALQTLPEHRRRGLGSRLVAALARGIAERGITPFA-VVVAGNTPSRRLYEKLGFR 78
Acetyltransf_3 pfam13302
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 34-139 4.83e-07

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 379112 [Multi-domain]  Cd Length: 139  Bit Score: 46.57  E-value: 4.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834075   34 PRLPESMVGWFAAKRAGGFPVIG----VEDADGTLMGFASYGTFRAWPAfkySVEHAIYVHQDHRGKGLGRVLLQALIAA 109
Cdd:pfam13302  32 PLTLEEAREWLARIWAADEAERGygwaIELKDTGFIGSIGLYDIDGEPE---RAELGYWLGPDYWGKGYATEAVRALLEY 108

                          90       100       110
                  ....*....|....*....|....*....|.
gi 492834075  110 A-EERGVHVLVGGIDASNQASIALHQQFGFT 139
Cdd:pfam13302 109 AfEELGLPRLVARIDPENTASRRVLEKLGFK 139
GNAT_acetyltran pfam12746
GNAT acetyltransferase; Many of the members are annotated s being Zwittermicin A resistance ...
 87-140 5.20e-06

GNAT acetyltransferase; Many of the members are annotated s being Zwittermicin A resistance proteins, whereas others are listed as being GNAT acetyltransferases. The family has similarities to the GNAT acetyltransferase family.


Pssm-ID: 403833  Cd Length: 239  Bit Score: 44.96  E-value: 5.20e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 492834075   87 IYVHQDHRGKGLGRVLLQALIAAAEERGvhvLVGGIDASNQASIALHQQFGFTH 140
Cdd:pfam12746 182 IDTHPDYRGKGLATICAAALILECLKRG---LYPSWDAHNEASVALAEKLGYEF 232
PRK10151 PRK10151
50S ribosomal protein L7/L12-serine acetyltransferase;
91-167 1.17e-05

50S ribosomal protein L7/L12-serine acetyltransferase;


Pssm-ID: 182270  Cd Length: 179  Bit Score: 43.60  E-value: 1.17e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492834075  91 QDHRGKGLGRVLLQALIAAAEERG-VHVLVGGIDASNQASIALHQQFGFTHAGTVREAGFKFGRWLDLAFYQRILATP 167
Cdd:PRK10151 102 ESHQGQGIISQALQALIHHYAQSGeLRRFVIKCRVDNPASNQVALRNGFTLEGCLKQAEYLNGAYDDVNLYARIIDSD 179
PRK03624 PRK03624
putative acetyltransferase; Provisional
 62-156 7.87e-05

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 40.68  E-value: 7.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834075  62 GTLMGfaSYGTFRAWpafKYSVEhaiyVHQDHRGKGLGRVLLQALIAAAEERG---VHVLVggiDASNQASIALHQQFGF 138
Cdd:PRK03624  58 GTVMG--GYDGHRGW---AYYLA----VHPDFRGRGIGRALVARLEKKLIARGcpkINLQV---REDNDAVLGFYEALGY 125

                         90
                 ....*....|....*...
gi 492834075 139 THagtvrEAGFKFGRWLD 156
Cdd:PRK03624 126 EE-----QDRISLGKRLI 138
ectoine_EctA TIGR02406
diaminobutyrate acetyltransferase; This enzyme family is the EctA of ectoine biosynthesis. ...
 89-149 2.97e-03

diaminobutyrate acetyltransferase; This enzyme family is the EctA of ectoine biosynthesis. Ectoine is a compatible solute, analagous to trehalose, betaines, etc., found often in halotolerant organisms. EctA is L-2,4-diaminobutyric acid acetyltransferase, also called DABA acetyltransferase. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 131459  Cd Length: 157  Bit Score: 36.24  E-value: 2.97e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 492834075   89 VHQDHRGKGLGRVLLQALIAAAEERGVHVLVGGIDASNQASIALHQQFGFTHAGTVREAGF 149
Cdd:TIGR02406  74 VDPRARGKGLARRLLEALLERVACERVRHLETTITPDNQASRALFKALARRRGVHLIEEPF 134
YidJ COG2388
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
61-117 3.07e-03

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 441953 [Multi-domain]  Cd Length: 88  Bit Score: 35.13  E-value: 3.07e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 492834075  61 DGTLMGFASYgtfrAWPAFKYSVEHAiYVHQDHRGKGLGRVLLQALIAAAEERGVHV 117
Cdd:COG2388   17 DGELAGELTY----RLEGGVIIITHT-EVPPALRGQGIASALVEAALDDARERGLKV 68
TmcA COG1444
tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]; tRNA ...
 87-115 4.01e-03

tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]; tRNA(Met) C34 N-acetyltransferase TmcA is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441053 [Multi-domain]  Cd Length: 703  Bit Score: 37.12  E-value: 4.01e-03
                         10        20
                 ....*....|....*....|....*....
gi 492834075  87 IYVHQDHRGKGLGRVLLQALIAAAEERGV 115
Cdd:COG1444  491 IAVHPALQRRGLGSRLLAEIREEAKEEGL 519
PRK07757 PRK07757
N-acetyltransferase;
89-115 6.68e-03

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 35.17  E-value: 6.68e-03
                         10        20
                 ....*....|....*....|....*..
gi 492834075  89 VHQDHRGKGLGRVLLQALIAAAEERGV 115
Cdd:PRK07757  73 VSEDYRGQGIGRMLVEACLEEARELGV 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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