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Conserved domains on  [gi|493096492|ref|WP_006133590|]
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MULTISPECIES: P-type DNA transfer ATPase VirB11 [Brucella]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 31-344 1.07e-144

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member TIGR02788:

Pssm-ID: 476819  Cd Length: 308  Bit Score: 411.75  E-value: 1.07e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492   31 WLDDPQITEVCVNRPGEVFCERASAWEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPMGERIQIVRPPACE 110
Cdd:TIGR02788   1 FLDDEDVTEICINRPGEVWVEGPGGWQRFDVPDLTFSHLMRLARAIASFSKQSISEENPILSATLPGGERVQIVIPPACE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  111 HGTISVTIRKPSFTRRTLEDYAQQGFFKHVRPMSKSLTPFEQELLALKEAGDYMSFLRRAVQLERVIVVAGETGSGKTTL 190
Cdd:TIGR02788  81 NDTVSITIRKPSLVDFSLDDYEEKGFFDTVRAQSGTLSDNDEQLLELLDAGDIKEFLRLAIASRKNIIISGGTGSGKTTF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  191 MKALMQEIPFDQRLITIEDVPELFLPdHPNHVHLFYPSEAKEEenAPVTAATLLRSCLRMKPTRILLAELRGGEAYDFIN 270
Cdd:TIGR02788 161 LKSLVDEIPKDERIITIEDTREIFLP-HPNYVHLFYSKGGQGL--AKVTPKDLLQSCLRMRPDRIILGELRGDEAFDFIR 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493096492  271 VAASGHGGSITSCHAGSCELTFERLALMVLQNRQGRQLPYEIIRRLLylvVDVVVHVHNGVHDGTGRHISEVWY 344
Cdd:TIGR02788 238 AVNTGHPGSITTLHAGSPEEAFEQLALMVKSSQAGLGLDFAYIVKLV---REVIDIVVQINRRGGGRKITEVYF 308
 
Name Accession Description Interval E-value
VirB11 TIGR02788
P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of ...
 31-344 1.07e-144

P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of Agrobacterium Ti plasmids where it is involved in the type IV secretion system for DNA transfer. VirB11 is believed to be an ATPase. VirB11 is a homolog of the P-like conjugation system TrbB protein and the Flp pilus sytem protein TadA.


Pssm-ID: 274301  Cd Length: 308  Bit Score: 411.75  E-value: 1.07e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492   31 WLDDPQITEVCVNRPGEVFCERASAWEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPMGERIQIVRPPACE 110
Cdd:TIGR02788   1 FLDDEDVTEICINRPGEVWVEGPGGWQRFDVPDLTFSHLMRLARAIASFSKQSISEENPILSATLPGGERVQIVIPPACE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  111 HGTISVTIRKPSFTRRTLEDYAQQGFFKHVRPMSKSLTPFEQELLALKEAGDYMSFLRRAVQLERVIVVAGETGSGKTTL 190
Cdd:TIGR02788  81 NDTVSITIRKPSLVDFSLDDYEEKGFFDTVRAQSGTLSDNDEQLLELLDAGDIKEFLRLAIASRKNIIISGGTGSGKTTF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  191 MKALMQEIPFDQRLITIEDVPELFLPdHPNHVHLFYPSEAKEEenAPVTAATLLRSCLRMKPTRILLAELRGGEAYDFIN 270
Cdd:TIGR02788 161 LKSLVDEIPKDERIITIEDTREIFLP-HPNYVHLFYSKGGQGL--AKVTPKDLLQSCLRMRPDRIILGELRGDEAFDFIR 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493096492  271 VAASGHGGSITSCHAGSCELTFERLALMVLQNRQGRQLPYEIIRRLLylvVDVVVHVHNGVHDGTGRHISEVWY 344
Cdd:TIGR02788 238 AVNTGHPGSITTLHAGSPEEAFEQLALMVKSSQAGLGLDFAYIVKLV---REVIDIVVQINRRGGGRKITEVYF 308
PRK13900 PRK13900
type IV secretion system ATPase VirB11; Provisional
 19-349 4.10e-79

type IV secretion system ATPase VirB11; Provisional


Pssm-ID: 184381  Cd Length: 332  Bit Score: 245.44  E-value: 4.10e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  19 ASVNFHLEPLRPWLDDPQITEVCVNRPGEVFCERASAWEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPMG 98
Cdd:PRK13900   6 AALETYLEPLKNIFAEDGVNEISINKPGEVWVEKKGDIRCEQIPELDLSHLKALGRLVAQATEQKISEEKPLLSATLPNG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  99 ERIQIVRPPACEHGTISVTIRKPSFTRRTLEDYAQQGFFKHVRPMSKSLtPFEQELLALKEAGDYMSFLRRAVQLERVIV 178
Cdd:PRK13900  86 YRIQIVFPPACEIGQIVYSIRKPSGMQLTLDDYEKMGAFDETATESLVD-EDDVILNELLAEKKIKEFLEHAVISKKNII 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 179 VAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPDHPNHVHLFypSEAKEEENAPVTAATLLRSCLRMKPTRILLA 258
Cdd:PRK13900 165 ISGGTSTGKTTFTNAALREIPAIERLITVEDAREIVLSNHPNRVHLL--ASKGGQGRAKVTTQDLIEACLRLRPDRIIVG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 259 ELRGGEAYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNRQGRQlPYEIIRrllYLVVDVVVHVHNGVHDGTGRH 338
Cdd:PRK13900 243 ELRGAEAFSFLRAINTGHPGSISTLHADSPAMAIEQLKLMVMQAGLGMP-PDQIKK---YILNVVDIVVQLKRGSGGKRY 318

                        330
                 ....*....|.
gi 493096492 339 ISEVWYDPNTK 349
Cdd:PRK13900 319 VSEIYFTKNKN 329
CpaF COG4962
Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and ...
 25-317 2.80e-73

Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 443988 [Multi-domain]  Cd Length: 386  Bit Score: 232.36  E-value: 2.80e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  25 LEPLRPWLDDPQITEVCVNRPGEVFCERASAWEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPMGERIQIV 104
Cdd:COG4962   56 LGPLEPLLDDPDVTDIMVNGPDEVFVERGGRLERTDVRFDSEEELRRLIERIAARVGRRLDESSPIVDARLPDGSRVNAV 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 105 RPPACEHGTiSVTIRKPSFTRRTLEDYAQQGffkhvrpmskSLTPfeqellalkeagDYMSFLRRAVQLERVIVVAGETG 184
Cdd:COG4962  136 IPPVARDGP-SLSIRKFRKRPLTLEDLVALG----------SLTP------------EMAEFLRAAVRARLNILVSGGTG 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 185 SGKTTLMKALMQEIPFDQRLITIEDVPELFLpDHPNHVHLfypsEAKE---EENAPVTAATLLRSCLRMKPTRILLAELR 261
Cdd:COG4962  193 SGKTTLLNALSGFIPPDERIVTIEDAAELQL-QHPHVVRL----ETRPpnvEGAGEVTLRDLVRNALRMRPDRIIVGEVR 267

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 493096492 262 GGEAYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNrqGRQLPYEIIRRLL 317
Cdd:COG4962  268 GAEALDMLQAMNTGHDGSMSTLHANSARDALARLETLALMA--GENLPREAVRRQI 321
VirB11-like_ATPase cd01130
Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, ...
 163-346 9.94e-71

Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir (virulence) proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the bacterial Ti (tumor-inducing)-plasmid into plant cells. The pilus is a fibrous cell surface organelle, which mediates adhesion between bacteria during conjugative transfer or between bacteria and host eukaryotic cells during infection. VirB11-related ATPases include Sulfolobus acidocaldarius FlaI, which plays key roles in archaellum (archaeal flagellum) assembly and motility functions, and the pilus assembly proteins CpaF/TadA and TrbB. This alignment contains the C-terminal domain, which is the ATPase.


Pssm-ID: 410874 [Multi-domain]  Cd Length: 177  Bit Score: 218.56  E-value: 9.94e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 163 YMSFLRRAVQLERVIVVAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPdHPNHVHLFYPSEAKEEenAPVTAAT 242
Cdd:cd01130    1 MAAFLRLAVRARKNILISGGTGSGKTTLLNALLSFIPPDERIVTIEDTRELQLP-HPNVVHLLTRPGGGEK--GEVTMAD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 243 LLRSCLRMKPTRILLAELRGGEAYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNrqGRQLPYEIIRRLL----- 317
Cdd:cd01130   78 LLKAALRMRPDRIIVGEVRGGEAYDMLQAMNTGHPGSITTIHANSAEDAIDRLATLVLEA--GVNLDEEALRRLIasaid 155

                        170       180       190
                 ....*....|....*....|....*....|..
gi 493096492 318 ---YLvvdvvvhvhnGVHDGTGRHISEVWYDP 346
Cdd:cd01130  156 vivHV----------KRLGDGVRRVTEIYEVP 177
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
 27-301 1.69e-38

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 138.19  E-value: 1.69e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492   27 PLRPWldDPQITEVCVNRPGEVF--CERASAwEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPM-----GE 99
Cdd:pfam00437   4 PLEAL--DEGASDIHVEPPERIVwiRFRVDG-VLREIPFPDADALARLISRIKVMARLDISERRPPQDGRLPLriggkGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  100 RIQIVRPPACEHGTISVTIRKPSFTRRTLEDYAQQGFFKhvrpmsksltpfeqellalkeaGDYMSFLRravQLERVIVV 179
Cdd:pfam00437  81 RVRVSTLPTAGGEKLVIRLLDPSNVALSLDELGMTGAQD----------------------EALLEFLR---QPRGNILV 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  180 AGETGSGKTTLMKALMQEIP-FDQRLITIEDVPELfLPDHPNHVHLfypseakeEENAPVTAATLLRSCLRMKPTRILLA 258
Cdd:pfam00437 136 TGPTGSGKTTTLYAALGELNtRDENIVTVEDPVEI-QLEGINQVQL--------NARAGVTFADLLRAILRQDPDRIMVG 206

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 493096492  259 ELRGGEAYDF-INVAASGHGGsITSCHAGSCELTFERLALMVLQ 301
Cdd:pfam00437 207 EIRDLETAEIaLQAANTGHLV-LSTLHTNSAAGALTRLQDMGVP 249
ATPase_ComGA NF041000
competence type IV pilus ATPase ComGA;
177-295 2.77e-10

competence type IV pilus ATPase ComGA;


Pssm-ID: 468930 [Multi-domain]  Cd Length: 265  Bit Score: 60.15  E-value: 2.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 177 IVVAGETGSGKTTLMKALMQEIPFDQRLITIEDvpelflpdhpnhvhlfyPSEAKEE--------ENAPVTAATLLRSCL 248
Cdd:NF041000 131 ILFSGPTGSGKTTTMYSLARKLALNKQVITIED-----------------PVEIKEPnflqlqvnEKAGMTYDTLLKAAL 193

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 493096492 249 RMKPTRILLAELRGGE-AYDFINVAASGHgGSITSCHAGSCELTFERL 295
Cdd:NF041000 194 RHRPDILIIGEIRDAEtAKAAIRAALTGH-LVLSTVHAKSAAGVIYRL 240
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 175-257 6.07e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 39.66  E-value: 6.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492   175 RVIVVAGETGSGKTTLMKALMQEIPFDQRLItIEDVPELFLPDHPNHVHLFYpSEAKEEENAPVTAATLLRSCLRMKPTR 254
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPPGGGV-IYIDGEDILEEVLDQLLLII-VGGKKASGSGELRLRLALALARKLKPD 80


                   ...
gi 493096492   255 ILL 257
Cdd:smart00382  81 VLI 83
 
Name Accession Description Interval E-value
VirB11 TIGR02788
P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of ...
 31-344 1.07e-144

P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of Agrobacterium Ti plasmids where it is involved in the type IV secretion system for DNA transfer. VirB11 is believed to be an ATPase. VirB11 is a homolog of the P-like conjugation system TrbB protein and the Flp pilus sytem protein TadA.


Pssm-ID: 274301  Cd Length: 308  Bit Score: 411.75  E-value: 1.07e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492   31 WLDDPQITEVCVNRPGEVFCERASAWEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPMGERIQIVRPPACE 110
Cdd:TIGR02788   1 FLDDEDVTEICINRPGEVWVEGPGGWQRFDVPDLTFSHLMRLARAIASFSKQSISEENPILSATLPGGERVQIVIPPACE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  111 HGTISVTIRKPSFTRRTLEDYAQQGFFKHVRPMSKSLTPFEQELLALKEAGDYMSFLRRAVQLERVIVVAGETGSGKTTL 190
Cdd:TIGR02788  81 NDTVSITIRKPSLVDFSLDDYEEKGFFDTVRAQSGTLSDNDEQLLELLDAGDIKEFLRLAIASRKNIIISGGTGSGKTTF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  191 MKALMQEIPFDQRLITIEDVPELFLPdHPNHVHLFYPSEAKEEenAPVTAATLLRSCLRMKPTRILLAELRGGEAYDFIN 270
Cdd:TIGR02788 161 LKSLVDEIPKDERIITIEDTREIFLP-HPNYVHLFYSKGGQGL--AKVTPKDLLQSCLRMRPDRIILGELRGDEAFDFIR 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493096492  271 VAASGHGGSITSCHAGSCELTFERLALMVLQNRQGRQLPYEIIRRLLylvVDVVVHVHNGVHDGTGRHISEVWY 344
Cdd:TIGR02788 238 AVNTGHPGSITTLHAGSPEEAFEQLALMVKSSQAGLGLDFAYIVKLV---REVIDIVVQINRRGGGRKITEVYF 308
PRK13900 PRK13900
type IV secretion system ATPase VirB11; Provisional
 19-349 4.10e-79

type IV secretion system ATPase VirB11; Provisional


Pssm-ID: 184381  Cd Length: 332  Bit Score: 245.44  E-value: 4.10e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  19 ASVNFHLEPLRPWLDDPQITEVCVNRPGEVFCERASAWEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPMG 98
Cdd:PRK13900   6 AALETYLEPLKNIFAEDGVNEISINKPGEVWVEKKGDIRCEQIPELDLSHLKALGRLVAQATEQKISEEKPLLSATLPNG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  99 ERIQIVRPPACEHGTISVTIRKPSFTRRTLEDYAQQGFFKHVRPMSKSLtPFEQELLALKEAGDYMSFLRRAVQLERVIV 178
Cdd:PRK13900  86 YRIQIVFPPACEIGQIVYSIRKPSGMQLTLDDYEKMGAFDETATESLVD-EDDVILNELLAEKKIKEFLEHAVISKKNII 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 179 VAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPDHPNHVHLFypSEAKEEENAPVTAATLLRSCLRMKPTRILLA 258
Cdd:PRK13900 165 ISGGTSTGKTTFTNAALREIPAIERLITVEDAREIVLSNHPNRVHLL--ASKGGQGRAKVTTQDLIEACLRLRPDRIIVG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 259 ELRGGEAYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNRQGRQlPYEIIRrllYLVVDVVVHVHNGVHDGTGRH 338
Cdd:PRK13900 243 ELRGAEAFSFLRAINTGHPGSISTLHADSPAMAIEQLKLMVMQAGLGMP-PDQIKK---YILNVVDIVVQLKRGSGGKRY 318

                        330
                 ....*....|.
gi 493096492 339 ISEVWYDPNTK 349
Cdd:PRK13900 319 VSEIYFTKNKN 329
CpaF COG4962
Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and ...
 25-317 2.80e-73

Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 443988 [Multi-domain]  Cd Length: 386  Bit Score: 232.36  E-value: 2.80e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  25 LEPLRPWLDDPQITEVCVNRPGEVFCERASAWEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPMGERIQIV 104
Cdd:COG4962   56 LGPLEPLLDDPDVTDIMVNGPDEVFVERGGRLERTDVRFDSEEELRRLIERIAARVGRRLDESSPIVDARLPDGSRVNAV 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 105 RPPACEHGTiSVTIRKPSFTRRTLEDYAQQGffkhvrpmskSLTPfeqellalkeagDYMSFLRRAVQLERVIVVAGETG 184
Cdd:COG4962  136 IPPVARDGP-SLSIRKFRKRPLTLEDLVALG----------SLTP------------EMAEFLRAAVRARLNILVSGGTG 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 185 SGKTTLMKALMQEIPFDQRLITIEDVPELFLpDHPNHVHLfypsEAKE---EENAPVTAATLLRSCLRMKPTRILLAELR 261
Cdd:COG4962  193 SGKTTLLNALSGFIPPDERIVTIEDAAELQL-QHPHVVRL----ETRPpnvEGAGEVTLRDLVRNALRMRPDRIIVGEVR 267

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 493096492 262 GGEAYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNrqGRQLPYEIIRRLL 317
Cdd:COG4962  268 GAEALDMLQAMNTGHDGSMSTLHANSARDALARLETLALMA--GENLPREAVRRQI 321
VirB11-like_ATPase cd01130
Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, ...
 163-346 9.94e-71

Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir (virulence) proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the bacterial Ti (tumor-inducing)-plasmid into plant cells. The pilus is a fibrous cell surface organelle, which mediates adhesion between bacteria during conjugative transfer or between bacteria and host eukaryotic cells during infection. VirB11-related ATPases include Sulfolobus acidocaldarius FlaI, which plays key roles in archaellum (archaeal flagellum) assembly and motility functions, and the pilus assembly proteins CpaF/TadA and TrbB. This alignment contains the C-terminal domain, which is the ATPase.


Pssm-ID: 410874 [Multi-domain]  Cd Length: 177  Bit Score: 218.56  E-value: 9.94e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 163 YMSFLRRAVQLERVIVVAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPdHPNHVHLFYPSEAKEEenAPVTAAT 242
Cdd:cd01130    1 MAAFLRLAVRARKNILISGGTGSGKTTLLNALLSFIPPDERIVTIEDTRELQLP-HPNVVHLLTRPGGGEK--GEVTMAD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 243 LLRSCLRMKPTRILLAELRGGEAYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNrqGRQLPYEIIRRLL----- 317
Cdd:cd01130   78 LLKAALRMRPDRIIVGEVRGGEAYDMLQAMNTGHPGSITTIHANSAEDAIDRLATLVLEA--GVNLDEEALRRLIasaid 155

                        170       180       190
                 ....*....|....*....|....*....|..
gi 493096492 318 ---YLvvdvvvhvhnGVHDGTGRHISEVWYDP 346
Cdd:cd01130  156 vivHV----------KRLGDGVRRVTEIYEVP 177
PRK13851 PRK13851
type IV secretion system protein VirB11; Provisional
 23-350 1.95e-64

type IV secretion system protein VirB11; Provisional


Pssm-ID: 172375  Cd Length: 344  Bit Score: 208.21  E-value: 1.95e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  23 FHLEPLRPWLDDPQITEVCVNRPGEVFCERASAWEYYAVPnLDYEHLISLGTATARFVDQDISDSRPVLSAILPMGERIQ 102
Cdd:PRK13851   9 FLLKPVLEWLDDPRTEEVAINRPGEAFVRQAGVFTKFPLP-LSYDDLEDIAILAGALRKQDVGPRNPLCATELPGGERLQ 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 103 IVRPPACEHGTISVTIRKPSFTRRTLEDYA---QQGFFKHVRPMSKSLTPFEQELLALKEAGDYMSFLRRAVQLERVIVV 179
Cdd:PRK13851  88 ICLPPTVPSGTVSLTIRRPSSRVSELKEVSsryDASRWNQWQERRKRRDQLDEAILRHYDNGDLEAFLHACVVGRLTMLL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 180 AGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPdHPNHVHLFYPSEAKEEenAPVTAATLLRSCLRMKPTRILLAE 259
Cdd:PRK13851 168 CGPTGSGKTTMSKTLISAIPPQERLITIEDTLELVIP-HENHVRLLYSKNGAGL--GAVTAEHLLQASLRMRPDRILLGE 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 260 LRGGEAYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNRQGRQLPYeiiRRLLYLVVDVVVHVHNGVHDGTGRHI 339
Cdd:PRK13851 245 MRDDAAWAYLSEVVSGHPGSISTIHGANPVQGFKKLFSLVKSSAQGASLED---RTLIDMLATAIDVIVPFRAYGDVYEV 321

                        330
                 ....*....|.
gi 493096492 340 SEVWYDPNTKR 350
Cdd:PRK13851 322 GEIWLAADARR 332
VirB11 COG0630
Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell ...
 25-295 3.81e-41

Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell motility, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440395 [Multi-domain]  Cd Length: 462  Bit Score: 149.85  E-value: 3.81e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  25 LEPLRPWLDDPQITEVCVNRPGE-VFcerasAW--EYYAVP-NL---DYEHLISLGTATARFVDQDISDSRPVLSAILPM 97
Cdd:COG0630  161 YGKLDPLMRDPNIEDISCNGVGIpVY-----VYhrDYERIPtNIvfeSEEELDNFVVKLAQRSGKHISVARPIVDATLPD 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  98 GERIQIV-RPPACEHGTiSVTIRKpsftrrtledyaqqgfFKHVrPMS-------KSLTPfeqELLAlkeagdymsFLRR 169
Cdd:COG0630  236 GSRIALTlGPEVSRRGS-SFTIRK----------------FREV-PLTpidliewGTLSP---ELAA---------YLWL 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 170 AVQLERVIVVAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPdHPNHVHLfYPSEAKEEENAPVTAATLLRSCLR 249
Cdd:COG0630  286 LLENGKSVLVAGGTASGKTTLLNALLSFIPPDAKIVTIEDTRELNLP-HENWISL-VTRESFGGEEGDVTMFDLLKAALR 363

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 493096492 250 MKPTRILLAELRGGEAYDFINVAASGHGGsITSCHAGSCELTFERL 295
Cdd:COG0630  364 QRPDYIVVGEVRGEEAYTLFQAMATGHGV-LSTFHADSVESAINRL 408
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
 27-301 1.69e-38

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 138.19  E-value: 1.69e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492   27 PLRPWldDPQITEVCVNRPGEVF--CERASAwEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPM-----GE 99
Cdd:pfam00437   4 PLEAL--DEGASDIHVEPPERIVwiRFRVDG-VLREIPFPDADALARLISRIKVMARLDISERRPPQDGRLPLriggkGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  100 RIQIVRPPACEHGTISVTIRKPSFTRRTLEDYAQQGFFKhvrpmsksltpfeqellalkeaGDYMSFLRravQLERVIVV 179
Cdd:pfam00437  81 RVRVSTLPTAGGEKLVIRLLDPSNVALSLDELGMTGAQD----------------------EALLEFLR---QPRGNILV 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  180 AGETGSGKTTLMKALMQEIP-FDQRLITIEDVPELfLPDHPNHVHLfypseakeEENAPVTAATLLRSCLRMKPTRILLA 258
Cdd:pfam00437 136 TGPTGSGKTTTLYAALGELNtRDENIVTVEDPVEI-QLEGINQVQL--------NARAGVTFADLLRAILRQDPDRIMVG 206

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 493096492  259 ELRGGEAYDF-INVAASGHGGsITSCHAGSCELTFERLALMVLQ 301
Cdd:pfam00437 207 EIRDLETAEIaLQAANTGHLV-LSTLHTNSAAGALTRLQDMGVP 249
type_II_IV_secretion_ATPases cd19477
type II/type IV hexameric secretion ATPases; RecA-like NTPases. This family includes the NTP ...
 165-312 3.86e-34

type II/type IV hexameric secretion ATPases; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410885 [Multi-domain]  Cd Length: 168  Bit Score: 123.66  E-value: 3.86e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 165 SFLRRAVQLERVIVVAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPDHPNHVHLFYpseakeeeNAPVTAATLL 244
Cdd:cd19477    1 SAIKDGIAIGKNVIVCGGTGSGKTTYIKSILEFIPKEERIISIEDTEEIVFKHHKNYTQLFF--------GGNITSADCL 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493096492 245 RSCLRMKPTRILLAELRGGEAYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNRQGRQLPYEI 312
Cdd:cd19477   73 KSCLRQRPDRIILGELRSSEAYDFYNVLCSGHKGTLTTLHAGSSEEAFIRLAN*SSSNSAARNIKFES 140
PRK13894 PRK13894
conjugal transfer ATPase TrbB; Provisional
 32-302 7.01e-24

conjugal transfer ATPase TrbB; Provisional


Pssm-ID: 184377  Cd Length: 319  Bit Score: 100.20  E-value: 7.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  32 LDDPQITEVCVNRPGEVFCERASAweyyavpnlDYEHLISLGTATAR--------FVDQDISDSRPVLSAILPM-GERIQ 102
Cdd:PRK13894  30 LNDPKTVEIMLNADGKLWQERLGE---------PMRCIGTLRVAQAQaiietiagYHGKEVTRSKPILEGELPLdGSRFA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 103 IVRPPACEHGTISvtIRKPSFTRRTLEDYAQQGFfkhvrpmsksLTPFEQELLalkeagdymsflRRAVQLERVIVVAGE 182
Cdd:PRK13894 101 GQLPPVVPAPTFA--IRKKAVAIFTLDQYVERGI----------MTAAQREAI------------IAAVRAHRNILVIGG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 183 TGSGKTTLMKALMQE-IPFD--QRLITIEDVPELFLPDHpNHVHlFYPSEAkeeenapVTAATLLRSCLRMKPTRILLAE 259
Cdd:PRK13894 157 TGSGKTTLVNAIINEmVIQDptERVFIIEDTGEIQCAAE-NYVQ-YHTSID-------VNMTALLKTTLRMRPDRILVGE 227

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 493096492 260 LRGGEAYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQN 302
Cdd:PRK13894 228 VRGPEALDLLMAWNTGHEGGAATLHANNAKAGLDRLKSLISMH 270
PRK13833 PRK13833
conjugal transfer protein TrbB; Provisional
 32-295 3.61e-20

conjugal transfer protein TrbB; Provisional


Pssm-ID: 172360 [Multi-domain]  Cd Length: 323  Bit Score: 89.86  E-value: 3.61e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492  32 LDDPQITEVCVNRPGEVFCER-----ASAWEYYAVpnlDYEHLISlgtATARFVDQDISDSRPVLSAILPMG-ERIQIVR 105
Cdd:PRK13833  26 LDDATVVEIMLNPDGKLFIERlghgvAPAGEMSAA---AAEVVIG---SVAHALQSEADDERPIISGELPIGgHRFEGLL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 106 PPACehGTISVTIRKPSFTRRTLEDYAQQGffkhvrpmsksltpfeqellALKEAgdYMSFLRRAVQLERVIVVAGETGS 185
Cdd:PRK13833 100 PPVV--SGPAFTIRRRASRLIPLDDYVTSK--------------------IMTEA--QASVIRSAIDSRLNIVISGGTGS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 186 GKTTLMKALMQEI----PfDQRLITIEDVPELFLPDHpNHVHLfypseakeEENAPVTAATLLRSCLRMKPTRILLAELR 261
Cdd:PRK13833 156 GKTTLANAVIAEIvasaP-EDRLVILEDTAEIQCAAE-NAVAL--------HTSDTVDMARLLKSTMRLRPDRIIVGEVR 225

                        250       260       270
                 ....*....|....*....|....*....|....
gi 493096492 262 GGEAYDFINVAASGHGGSITSCHAGSCELTFERL 295
Cdd:PRK13833 226 DGAALTLLKAWNTGHPGGVTTIHSNTAMSALRRL 259
PulE-GspE-like cd01129
PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II ...
 167-314 2.85e-12

PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II secretory pathway, the main terminal branch of the general secretory pathway (GSP). PulE is a cytoplasmic protein of the GSP, which contains an ATP binding site and a tetracysteine motif. This subgroup also includes PilB, a type IV pilus assembly ATPase, DotB, an ATPase of the type IVb secretion system, also known as the dot/icm system, Escherichia coli IncI plasmid-encoded conjugative transfer ATPase TraJ, and HofB.


Pssm-ID: 410873 [Multi-domain]  Cd Length: 159  Bit Score: 64.04  E-value: 2.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 167 LRRAVQLER-VIVVAGETGSGKTTLMKALMQEIPFDQR-LITIEDVPELFLPDhpnhvhlFYPSEAKEEENapVTAATLL 244
Cdd:cd01129    3 LRRLIKRPHgLILVTGPTGSGKTTTLYAMLRELNGPERnIITIEDPVEYQIPG-------INQSQVNEKIG--LTFADAL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 245 RSCLRMKPTRILLAELRGGE-AYDFINVAASGHgGSITSCHAGSCELTFERL--------------ALMVLQNRQGRQLP 309
Cdd:cd01129   74 RAILRQDPDIIMVGEIRDAEtAEIAIRAALTGH-LVLSTLHTNDALGAITRLldmgiepfllasalRGVIAQRLVGRTAI 152


                 ....*
gi 493096492 310 YEIIR 314
Cdd:cd01129  153 AEVLV 157
DotB_TraJ cd19516
dot/icm secretion system protein DotB-like; Defect in organelle trafficking (Dot)B is part of ...
 166-299 1.57e-10

dot/icm secretion system protein DotB-like; Defect in organelle trafficking (Dot)B is part of the type IVb secretion (T4bS) system, also known as the dot/icm system, and is the main energy supplier of the secretion system. It is an ATPase, similar to the VirB11 component of the T4aS systems. This family also includes Escherichia coli IncI plasmid-encoded conjugative transfer ATPase TraJ encoded on the tra (transfer) operon.


Pssm-ID: 410924 [Multi-domain]  Cd Length: 179  Bit Score: 59.31  E-value: 1.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 166 FLRRAVQLERVIVVAGETGSGKTTLMKALMQEI----PFDQRLITIEDvPELFLPDHPNHVHLFyPSEAKEEENAPVTAA 241
Cdd:cd19516    3 LVEALFPREGLVYVAGATGSGKSTLLAAIYRYIlendPPDRKIITYED-PIEFVYDGIKSKHSI-IVQSQIPRHFKSFAK 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 493096492 242 TlLRSCLRMKPTRILLAELRGGEAYD-FINVAASGHgGSITSCHAGSCELTFERLALMV 299
Cdd:cd19516   81 A-VREALRRKPSLIGVGELRDQETISaAVEASLTGH-PVYSTVHTKSVAETIRRLISLF 137
ATPase_ComGA NF041000
competence type IV pilus ATPase ComGA;
177-295 2.77e-10

competence type IV pilus ATPase ComGA;


Pssm-ID: 468930 [Multi-domain]  Cd Length: 265  Bit Score: 60.15  E-value: 2.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 177 IVVAGETGSGKTTLMKALMQEIPFDQRLITIEDvpelflpdhpnhvhlfyPSEAKEE--------ENAPVTAATLLRSCL 248
Cdd:NF041000 131 ILFSGPTGSGKTTTMYSLARKLALNKQVITIED-----------------PVEIKEPnflqlqvnEKAGMTYDTLLKAAL 193

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 493096492 249 RMKPTRILLAELRGGE-AYDFINVAASGHgGSITSCHAGSCELTFERL 295
Cdd:NF041000 194 RHRPDILIIGEIRDAEtAKAAIRAALTGH-LVLSTVHAKSAAGVIYRL 240
PilT COG2805
Type IV pilus assembly protein PilT, pilus retraction ATPase [Cell motility, Extracellular ...
 167-295 4.66e-07

Type IV pilus assembly protein PilT, pilus retraction ATPase [Cell motility, Extracellular structures];


Pssm-ID: 442056  Cd Length: 342  Bit Score: 50.86  E-value: 4.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 167 LRRAVQLER-VIVVAGETGSGKTTLMKALMQEI--PFDQRLITIEDvPELFLPDHPN----------HVHLFypseakee 233
Cdd:COG2805  117 LKELAELPRgLVLVTGPTGSGKSTTLAAMIDYIneTRAKHIITIED-PIEFVHKHKKslinqrevgrDTPSF-------- 187

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493096492 234 ENApvtaatlLRSCLRMKPTRILLAELRGGE----AydfINVAASGH--GGSItscHAGSCELTFERL 295
Cdd:COG2805  188 ANA-------LRAALREDPDVILVGEMRDLEtieaA---LTAAETGHlvFATL---HTNSAAQTIDRI 242
PilT cd01131
Pilus retraction ATPase PilT; Pilus retraction ATPase PilT is a nucleotide-binding protein ...
 177-295 1.23e-05

Pilus retraction ATPase PilT; Pilus retraction ATPase PilT is a nucleotide-binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism known as twitching motility.


Pssm-ID: 410875 [Multi-domain]  Cd Length: 223  Bit Score: 45.99  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492 177 IVVAGETGSGKTTLMKALMQEI--PFDQRLITIEDvPELFLpdHPNHVHLFYPSEAKEEEnapVTAATLLRSCLRMKPTR 254
Cdd:cd01131   24 VLVTGPTGSGKSTTLAAMIDYIneTRSKHIITIED-PIEFV--HKHKKSLINQREVGRDT---ESFAAALRAALREDPDV 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 493096492 255 ILLAELRGGEAYDF-INVAASGHgGSITSCHAGSCELTFERL 295
Cdd:cd01131   98 ILVGEMRDLETIELaLTAAETGH-LVFSTLHTNSAAQTIDRI 138
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
 146-207 1.83e-04

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 42.47  E-value: 1.83e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493096492 146 SLTPFEQELLALKEAGDYMSFLRRAV-QLERVIVVAGETGSGKTTLMKALMQEIPFDQRLITI 207
Cdd:COG3267   14 SLTPDPRFLFLSPSHREALARLEYALaQGGGFVVLTGEVGTGKTTLLRRLLERLPDDVKVAYI 76
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 175-257 6.07e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 39.66  E-value: 6.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493096492   175 RVIVVAGETGSGKTTLMKALMQEIPFDQRLItIEDVPELFLPDHPNHVHLFYpSEAKEEENAPVTAATLLRSCLRMKPTR 254
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPPGGGV-IYIDGEDILEEVLDQLLLII-VGGKKASGSGELRLRLALALARKLKPD 80


                   ...
gi 493096492   255 ILL 257
Cdd:smart00382  81 VLI 83
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
 175-226 7.22e-04

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 39.54  E-value: 7.22e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 493096492 175 RVIVVAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPDHPNHVHLFY 226
Cdd:cd00267   26 EIVALVGPNGSGKSTLLRAIAGLLKPTSGEILIDGKDIAKLPLEELRRRIGY 77
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
167-205 1.17e-03

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 40.83  E-value: 1.17e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 493096492 167 LRRAVQLERVIVVAGETGSGKTTLM-KALMQEIPFDQRLI 205
Cdd:COG1643   19 LLAALRAHQVVVLAAPPGAGKTTQLpLALLELGWGAGGRI 58
ABC_tran pfam00005
ABC transporter; ABC transporters for a large family of proteins responsible for translocation ...
 175-224 1.50e-03

ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.


Pssm-ID: 394964 [Multi-domain]  Cd Length: 150  Bit Score: 38.78  E-value: 1.50e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 493096492  175 RVIVVAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPDHPNHVHL 224
Cdd:pfam00005  12 EILALVGPNGAGKSTLLKLIAGLLSPTEGTILLDGQDLTDDERKSLRKEI 61
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
172-207 1.86e-03

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 38.81  E-value: 1.86e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 493096492 172 QLERVIVVAGETGSGKTTLMKALMQE-IPFDQRLITI 207
Cdd:COG1100    1 MGEKKIVVVGTGGVGKTSLVNRLVGDiFSLEKYLSTN 37
PulE COG2804
Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell ...
 177-209 5.64e-03

Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442055 [Multi-domain]  Cd Length: 561  Bit Score: 38.64  E-value: 5.64e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 493096492 177 IVVAGETGSGKTTLMKALMQEIPFDQR-LITIED 209
Cdd:COG2804  316 ILVTGPTGSGKTTTLYAALNELNTPERnIITVED 349
Gmk COG0194
Guanylate kinase [Nucleotide transport and metabolism];
175-199 7.29e-03

Guanylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 439964  Cd Length: 190  Bit Score: 36.97  E-value: 7.29e-03
                         10        20
                 ....*....|....*....|....*
gi 493096492 175 RVIVVAGETGSGKTTLMKALMQEIP 199
Cdd:COG0194    3 KLIVLSGPSGAGKTTLVKALLERDP 27
COG4928 COG4928
Predicted P-loop ATPase, KAP-like [General function prediction only];
176-208 7.99e-03

Predicted P-loop ATPase, KAP-like [General function prediction only];


Pssm-ID: 443956  Cd Length: 386  Bit Score: 37.97  E-value: 7.99e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 493096492 176 VIVVAGETGSGKTTLMKALMQEIPFDQRLITIE 208
Cdd:COG4928   31 VIGLDGEWGSGKTSFLNLIEKELESNEKVIVVY 63
MK0520 COG2401
ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction ...
 176-219 9.75e-03

ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only];


Pssm-ID: 441957 [Multi-domain]  Cd Length: 222  Bit Score: 36.86  E-value: 9.75e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 493096492 176 VIVVAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPDHP 219
Cdd:COG2401   58 IVLIVGASGSGKSTLLRLLAGALKGTPVAGCVDVPDNQFGREAS 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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