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Conserved domains on  [gi|493178445|ref|WP_006177740|]
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glycosyltransferase family 2 protein [Enterobacter cancerogenus]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10118426)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CATH:  3.90.550.10
CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  9445404|12691742|10508766|12200473|10521532
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 3-226 3.62e-54

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


:

Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 174.78  E-value: 3.62e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445   3 KLTVCLLTYNSARLLHQVLPPLIRIADEIVVVDSGSHDETLFILEEYKISSIYHPYAMHGEQMNIAISQSRNDWVLCMDS 82
Cdd:cd02511    1 TLSVVIITKNEERNIERCLESVKWAVDEIIVVDSGSTDRTVEIAKEYGAKVYQRWWDGFGAQRNFALELATNDWVLSLDA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445  83 DEILDEDTLEYIISLKSGEEPPADWgwsLSRYWYVLGERTRtiYPVSSPDYPLRLFNRRYVKFNNRPVDDKAVGAGQVTR 162
Cdd:cd02511   81 DERLTPELADEILALLATDDYDGYY---VPRRNFFLGRWIR--HGGWYPDRQLRLFRRGKARFEDGRVHEQVVVDGGVGI 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445 163 -IPGHVRHDTFYSLHEVFNKLNTYTSRVVK---YQALKPSIARGIVSA--IGAFFKWYLFSGAWRQGKIG 226
Cdd:cd02511  156 vLKGDILHYGYKSLEEFLEKHNRYSSLEAKdlaAKGKKRSLLKGLLLGrpLLAFLKMYILKRGFLDGRAG 225
 
Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 3-226 3.62e-54

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 174.78  E-value: 3.62e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445   3 KLTVCLLTYNSARLLHQVLPPLIRIADEIVVVDSGSHDETLFILEEYKISSIYHPYAMHGEQMNIAISQSRNDWVLCMDS 82
Cdd:cd02511    1 TLSVVIITKNEERNIERCLESVKWAVDEIIVVDSGSTDRTVEIAKEYGAKVYQRWWDGFGAQRNFALELATNDWVLSLDA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445  83 DEILDEDTLEYIISLKSGEEPPADWgwsLSRYWYVLGERTRtiYPVSSPDYPLRLFNRRYVKFNNRPVDDKAVGAGQVTR 162
Cdd:cd02511   81 DERLTPELADEILALLATDDYDGYY---VPRRNFFLGRWIR--HGGWYPDRQLRLFRRGKARFEDGRVHEQVVVDGGVGI 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445 163 -IPGHVRHDTFYSLHEVFNKLNTYTSRVVK---YQALKPSIARGIVSA--IGAFFKWYLFSGAWRQGKIG 226
Cdd:cd02511  156 vLKGDILHYGYKSLEEFLEKHNRYSSLEAKdlaAKGKKRSLLKGLLLGrpLLAFLKMYILKRGFLDGRAG 225
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-182 3.59e-18

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 80.13  E-value: 3.59e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445   1 MFKLTVCLLTYNSARLLHQVLPPLIRIAD---EIVVVDSGSHDETLFILEEY-----KISSIYHPYAM-HGEQMNIAISQ 71
Cdd:COG0463    1 MPLVSVVIPTYNEEEYLEEALESLLAQTYpdfEIIVVDDGSTDGTAEILRELaakdpRIRVIRLERNRgKGAARNAGLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445  72 SRNDWVLCMDSDEILDEDTLEYIISLKsgEEPPAD--WGWSLSRYWYVLGER--------TRTIYPVSSPDYPLRLFNRR 141
Cdd:COG0463   81 ARGDYIAFLDADDQLDPEKLEELVAAL--EEGPADlvYGSRLIREGESDLRRlgsrlfnlVRLLTNLPDSTSGFRLFRRE 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 493178445 142 YVK---FNNRPVDD----KAVGAG-QVTRIP-GHVRHDTFYSLHEVFNKL 182
Cdd:COG0463  159 VLEelgFDEGFLEDtellRALRHGfRIAEVPvRYRAGESKLNLRDLLRLL 208
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 5-147 7.97e-13

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 64.72  E-value: 7.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445    5 TVCLLTYNSARLLHQVLPPLIRI---ADEIVVVDSGSHDETLFILEEY-----KISSIYHPYAM-HGEQMNIAISQSRND 75
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQtypNFEIIVVDDGSTDGTVEIAEEYakkdpRVRVIRLPENRgKAGARNAGLRAATGD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493178445   76 WVLCMDSDEILDEDTLEYIISLKSGEEPPADWGWSLSRYWYVLGERTRTIYPVSSPDYPLRLFNRRYVKFNN 147
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFL 152
 
Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 3-226 3.62e-54

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 174.78  E-value: 3.62e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445   3 KLTVCLLTYNSARLLHQVLPPLIRIADEIVVVDSGSHDETLFILEEYKISSIYHPYAMHGEQMNIAISQSRNDWVLCMDS 82
Cdd:cd02511    1 TLSVVIITKNEERNIERCLESVKWAVDEIIVVDSGSTDRTVEIAKEYGAKVYQRWWDGFGAQRNFALELATNDWVLSLDA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445  83 DEILDEDTLEYIISLKSGEEPPADWgwsLSRYWYVLGERTRtiYPVSSPDYPLRLFNRRYVKFNNRPVDDKAVGAGQVTR 162
Cdd:cd02511   81 DERLTPELADEILALLATDDYDGYY---VPRRNFFLGRWIR--HGGWYPDRQLRLFRRGKARFEDGRVHEQVVVDGGVGI 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445 163 -IPGHVRHDTFYSLHEVFNKLNTYTSRVVK---YQALKPSIARGIVSA--IGAFFKWYLFSGAWRQGKIG 226
Cdd:cd02511  156 vLKGDILHYGYKSLEEFLEKHNRYSSLEAKdlaAKGKKRSLLKGLLLGrpLLAFLKMYILKRGFLDGRAG 225
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-182 3.59e-18

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 80.13  E-value: 3.59e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445   1 MFKLTVCLLTYNSARLLHQVLPPLIRIAD---EIVVVDSGSHDETLFILEEY-----KISSIYHPYAM-HGEQMNIAISQ 71
Cdd:COG0463    1 MPLVSVVIPTYNEEEYLEEALESLLAQTYpdfEIIVVDDGSTDGTAEILRELaakdpRIRVIRLERNRgKGAARNAGLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445  72 SRNDWVLCMDSDEILDEDTLEYIISLKsgEEPPAD--WGWSLSRYWYVLGER--------TRTIYPVSSPDYPLRLFNRR 141
Cdd:COG0463   81 ARGDYIAFLDADDQLDPEKLEELVAAL--EEGPADlvYGSRLIREGESDLRRlgsrlfnlVRLLTNLPDSTSGFRLFRRE 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 493178445 142 YVK---FNNRPVDD----KAVGAG-QVTRIP-GHVRHDTFYSLHEVFNKL 182
Cdd:COG0463  159 VLEelgFDEGFLEDtellRALRHGfRIAEVPvRYRAGESKLNLRDLLRLL 208
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-96 7.81e-14

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 68.48  E-value: 7.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445   1 MFKLTVCLLTYNSARLLHQVLPPLIR---IADEIVVVDSGSHDETLFILEEYKISS---IYHPYAM-HGEQMNIAISQSR 73
Cdd:COG1216    2 RPKVSVVIPTYNRPELLRRCLESLLAqtyPPFEVIVVDNGSTDGTAELLAALAFPRvrvIRNPENLgFAAARNLGLRAAG 81

                         90       100
                 ....*....|....*....|...
gi 493178445  74 NDWVLCMDSDEILDEDTLEYIIS 96
Cdd:COG1216   82 GDYLLFLDDDTVVEPDWLERLLA 104
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 5-147 7.97e-13

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 64.72  E-value: 7.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445    5 TVCLLTYNSARLLHQVLPPLIRI---ADEIVVVDSGSHDETLFILEEY-----KISSIYHPYAM-HGEQMNIAISQSRND 75
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQtypNFEIIVVDDGSTDGTVEIAEEYakkdpRVRVIRLPENRgKAGARNAGLRAATGD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493178445   76 WVLCMDSDEILDEDTLEYIISLKSGEEPPADWGWSLSRYWYVLGERTRTIYPVSSPDYPLRLFNRRYVKFNN 147
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFL 152
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 6-95 5.36e-11

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 59.44  E-value: 5.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445   6 VCLLTYNSARLLHQVLPPLIRI---ADEIVVVDSGSHDETLFILEEY------KISSIYHPYAMHGEQMNIAISQSRNDW 76
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLLAQtypNFEVIVVDDGSTDGTLEILEEYakkdprVIRVINEENQGLAAARNAGLKAARGEY 80

                         90
                 ....*....|....*....
gi 493178445  77 VLCMDSDEILDEDTLEYII 95
Cdd:cd00761   81 ILFLDADDLLLPDWLERLV 99
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 3-96 2.65e-09

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 56.67  E-value: 2.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445   3 KLTVCLLTYNSARLLHQVLPPLIRI-----ADEIVVVDSGSHDETLFILEEYK-----ISSIYHPYAMH-GEQMNIAISQ 71
Cdd:COG1215   30 RVSVIIPAYNEEAVIEETLRSLLAQdypkeKLEVIVVDDGSTDETAEIARELAaeyprVRVIERPENGGkAAALNAGLKA 109

                         90       100
                 ....*....|....*....|....*
gi 493178445  72 SRNDWVLCMDSDEILDEDTLEYIIS 96
Cdd:COG1215  110 ARGDIVVFLDADTVLDPDWLRRLVA 134
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 16-94 2.65e-09

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 55.31  E-value: 2.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445  16 LLHQVLPPLiriadEIVVVDSGSHDETLFILEEYKISSIYHPYAMHGEQ-------MNIAISQSRNDWVLCMDSDEILDE 88
Cdd:cd06423   19 LLALDYPKL-----EVIVVDDGSTDDTLEILEELAALYIRRVLVVRDKEnggkagaLNAGLRHAKGDIVVVLDADTILEP 93


                 ....*.
gi 493178445  89 DTLEYI 94
Cdd:cd06423   94 DALKRL 99
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 10-144 2.80e-08

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 52.19  E-value: 2.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445  10 TYNSARLLHQVLPPLIR-----IADEIVVVDSGSHDETLFILEEY-----KISSIYHPYAM-HGEQMNIAISQSRNDWVL 78
Cdd:cd04179    5 AYNEEENIPELVERLLAvleegYDYEIIVVDDGSTDGTAEIARELaarvpRVRVIRLSRNFgKGAAVRAGFKAARGDIVV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445  79 CMDSDeilDEDTLEYIISL-KSGEEPPAD------------WGWSLSRYW-----YVLgerTRTIYPVSSPDY--PLRLF 138
Cdd:cd04179   85 TMDAD---LQHPPEDIPKLlEKLLEGGADvvigsrfvrgggAGMPLLRRLgsrlfNFL---IRLLLGVRISDTqsGFRLF 158


                 ....*.
gi 493178445 139 NRRYVK 144
Cdd:cd04179  159 RREVLE 164
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 30-92 4.01e-08

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 52.62  E-value: 4.01e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493178445  30 EIVVVDSGSHDETLFILEEY-----KISSIYHPYAMHGEQMNIAISQSRNDWVLCMDSDEILDEDTLE 92
Cdd:cd02525   33 EIIVVDGGSTDGTREIVQEYaakdpRIRLIDNPKRIQSAGLNIGIRNSRGDIIIRVDAHAVYPKDYIL 100
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 5-143 2.39e-07

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 49.94  E-value: 2.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445   5 TVCLLTYNSAR--------LLHQVLPPliriaDEIVVVDSGSHDETLFILEEYkISSIYHPYAMHGEQMNI--------A 68
Cdd:cd04196    1 AVLMATYNGEKylreqldsILAQTYKN-----DELIISDDGSTDGTVEIIKEY-IDKDPFIIILIRNGKNLgvarnfesL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445  69 ISQSRNDWVLCMDSDEILDEDTLEYIISLKSGEEPPAdwgwsL--SRYWYV------LGERTRTIYPVSSPDYPLRLFNR 140
Cdd:cd04196   75 LQAADGDYVFFCDQDDIWLPDKLERLLKAFLKDDKPL-----LvySDLELVdengnpIGESFFEYQKIKPGTSFNNLLFQ 149


                 ...
gi 493178445 141 RYV 143
Cdd:cd04196  150 NVV 152
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 8-92 2.48e-07

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 49.48  E-value: 2.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445   8 LLTYNSARLLHQVLPPLIRIAD---EIVVVDSGSHDETLFILEEY--KISSIYHPYAMH-GEQMNIAISQSRNDWVLCMD 81
Cdd:cd04186    3 IVNYNSLEYLKACLDSLLAQTYpdfEVIVVDNASTDGSVELLRELfpEVRLIRNGENLGfGAGNNQGIREAKGDYVLLLN 82

                         90
                 ....*....|.
gi 493178445  82 SDEILDEDTLE 92
Cdd:cd04186   83 PDTVVEPGALL 93
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 10-108 2.92e-05

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 44.10  E-value: 2.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445  10 TYNSARLLHQVLPPLIRIAD---EIVVVDSGSHDETLFILEEYKISSIYHPyAMHGEQMNIAISQSRNDWVLCMDSDEIL 86
Cdd:cd02522    7 TLNEAENLPRLLASLRRLNPlplEIIVVDGGSTDGTVAIARSAGVVVISSP-KGRARQMNAGAAAARGDWLLFLHADTRL 85

                         90       100
                 ....*....|....*....|..
gi 493178445  87 DEDTLEYIISLKSgeEPPADWG 108
Cdd:cd02522   86 PPDWDAAIIETLR--ADGAVAG 105
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 10-107 3.84e-05

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 43.30  E-value: 3.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445  10 TYNSAR--------LLHQVLPPLiriadEIVVVDSGSHDETLFILEEY-----KISS-----IYHpyAmhgeqMNIAISQ 71
Cdd:cd06433    6 TYNQAEtleetidsVLSQTYPNI-----EYIVIDGGSTDGTVDIIKKYedkitYWISepdkgIYD--A-----MNKGIAL 73

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 493178445  72 SRNDWVLCMDSDEILDEDTLEYIISLKSgEEPPADW 107
Cdd:cd06433   74 ATGDIIGFLNSDDTLLPGALLAVVAAFA-EHPEVDV 108
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 16-96 1.04e-04

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 42.30  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445  16 LLHQVLPPliriaDEIVVVDSGS-HDETLFILEEYKIssiYHPYAMH--------GEQMNIAISQSRNDWVLCMDSDEIL 86
Cdd:cd04195   22 ILKQTLPP-----DEVVLVKDGPvTQSLNEVLEEFKR---KLPLKVVpleknrglGKALNEGLKHCTYDWVARMDTDDIS 93

                         90
                 ....*....|
gi 493178445  87 DEDTLEYIIS 96
Cdd:cd04195   94 LPDRFEKQLD 103
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 12-83 6.46e-04

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 39.96  E-value: 6.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445  12 NSARLLHQVL-----PPLIriadEIVVVDSGSHDETLFILEEYKISSIYHPYAMHGEQMNI---------AISQSRNDWV 77
Cdd:cd04192   11 NLPRLLQSLSaldypKEKF----EVILVDDHSTDGTVQILEFAAAKPNFQLKILNNSRVSIsgkknalttAIKAAKGDWI 86


                 ....*.
gi 493178445  78 LCMDSD 83
Cdd:cd04192   87 VTTDAD 92
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 10-89 1.13e-03

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 38.71  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445  10 TYNSAR--------LLHQVLPPliriaDEIVVVDSGSHDETLFILEEYK------ISSIYHPYAmhGEQ----MNIAISQ 71
Cdd:cd06420    5 TYNRPEalelvlksVLNQSILP-----FEVIIADDGSTEETKELIEEFKsqfpipIKHVWQEDE--GFRkakiRNKAIAA 77

                         90
                 ....*....|....*...
gi 493178445  72 SRNDWVLCMDSDEILDED 89
Cdd:cd06420   78 AKGDYLIFIDGDCIPHPD 95
Glyco_tranf_2_4 pfam13704
Glycosyl transferase family 2; Members of this family of prokaryotic proteins include putative ...
 28-90 1.80e-03

Glycosyl transferase family 2; Members of this family of prokaryotic proteins include putative glucosyltransferases,


Pssm-ID: 433416 [Multi-domain]  Cd Length: 97  Bit Score: 36.84  E-value: 1.80e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493178445   28 ADEIVVVDSGSHDETLFILEEYKISSIYHP------YAMHGEQMNIAISQ-SRNDWVLCMDSDEILDEDT 90
Cdd:pfam13704  19 FDHIYVYDNGSDDGTAEILARLPDVSILRSdlsykdARFQVDWRNALLARyAEADWVLVVDADEFLVYPP 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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