|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07006 |
PRK07006 |
isocitrate dehydrogenase; Reviewed |
8-416 |
0e+00 |
|
isocitrate dehydrogenase; Reviewed
Pssm-ID: 180792 Cd Length: 409 Bit Score: 910.21 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 8 PAEGAKITAQNGKLNVPHNPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQLYGQDVWLPQE 87
Cdd:PRK07006 1 PAEGEKITVNNGKLNVPNNPIIPFIEGDGIGPDITPAMLKVVDAAVEKAYKGERKISWMEIYAGEKATKVYGEDVWLPEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKA 167
Cdd:PRK07006 81 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVKRPEDTDMVIFRENSEDIYAGIEWKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 168 DSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAITNDRESVTLVHKGNIMKFTEGAFKDWGYQ 247
Cdd:PRK07006 161 GSAEAKKVIKFLQEEMGVKKIRFPETSGIGIKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 248 LAREEFGGELIDGGPWVKIKNPNNGKEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327
Cdd:PRK07006 241 LAEEEFGDELIDGGPWDKIKNPETGKEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGAN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWFEAADLIVKGMEGAINNKTVTYDFERLMEGAKLLKCSE 407
Cdd:PRK07006 321 INDGHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIASKTVTYDFARLMEGATEVKCSE 400
|
....*....
gi 495124531 408 FGDAIIANM 416
Cdd:PRK07006 401 FGDALIKNM 409
|
|
| prok_nadp_idh |
TIGR00183 |
isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent ... |
1-416 |
0e+00 |
|
isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; Prokaryotic NADP-dependent isocitrate dehydrogenases resemble their NAD-dependent counterparts and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent isocitrate dehydrogenases. [Energy metabolism, TCA cycle]
Pssm-ID: 272948 Cd Length: 416 Bit Score: 826.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 1 MESKVVVPAEGAKITAQNGKLNVPHNPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQLYGQ 80
Cdd:TIGR00183 1 MYEKVKPPAQGEKITYENGKLNVPNNPIIPYIEGDGIGVDVTPAAIKVLDAAVEKAYKGEKKIVWFEVYAGEKAYQLYGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 81 DVWLPQETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIY 160
Cdd:TIGR00183 81 DQWLPADTLDAIKEYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYKGVPSPVKHPEKVDMVIFRENTEDIY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 161 AGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAITNDRESVTLVHKGNIMKFTEGA 240
Cdd:TIGR00183 161 AGIEWAEGSEEAKKLIRFLQNELGVKKIRFPEDSGIGIKPISEEGTKRLVRAAIEYAIENDRKSVTLVHKGNIMKFTEGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 241 FKDWGYQLAREEFGGELIDGGPWVKIKNPNNGKEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320
Cdd:TIGR00183 241 FRDWGYELAKKEFGAECITWGLWDKYKNPNPGKEIVIKDRIADAFLQQILTRPDEYDVIATMNLNGDYISDALAAQVGGI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWFEAADLIVKGMEGAINNKTVTYDFERLMEGA 400
Cdd:TIGR00183 321 GIAPGANIGDEIGIFEATHGTAPKYAGQDKVNPGSIILSGEMMLEHMGWKEAADLIKKAMEKAIASKIVTYDFARLMDGA 400
|
410
....*....|....*.
gi 495124531 401 KLLKCSEFGDAIIANM 416
Cdd:TIGR00183 401 KEVKCSEFAEAIIENM 416
|
|
| Icd |
COG0538 |
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ... |
10-416 |
0e+00 |
|
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304 Cd Length: 409 Bit Score: 793.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 10 EGAKITAQNGKLNVPHNPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQLYGQdvWLPQETL 89
Cdd:COG0538 2 EGEKIKVEDGKLKVPDNPIIPFIEGDGIGPEITRAIWKVIDAAVEKAYGGKRDIEWKEVDAGEKARDETGD--WLPDETA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 90 DLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADS 169
Cdd:COG0538 80 EAIKEYGVGIKGPLTTPVGGGWRSLNVTIRQILDLYVCRRPVRYFKGVPSPVKHPEKVDIVIFRENTEDIYAGIEWKAGS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 170 ADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAITNDRESVTLVHKGNIMKFTEGAFKDWGYQLA 249
Cdd:COG0538 160 PEALKLIFFLEDEMGVTVIRFPEDSGIGIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 250 REEFGGELIDGGPWVKIKNPNNGKEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIG 329
Cdd:COG0538 240 EEEFGDKFITEGPWEKYKGPKPAGKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 330 DEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWFEAADLIVKGMEGAINNKTVTYDFERLMEGAKLLKCSEF 408
Cdd:COG0538 320 DDGgAEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKVTYDLARLMEGATELSTSEF 399
|
....*...
gi 495124531 409 GDAIIANM 416
Cdd:COG0538 400 GDAIIENL 407
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
28-412 |
1.27e-110 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 328.48 E-value: 1.27e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 28 IIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKgerKISWMEIYTGEKSTQLYGQdvWLPQETLDLIREYRVAIKGPLTTPV 107
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPL---EFEFEERDVGGAAIDETGE--PLPDETLEACKKADAVLLGAVGGPK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 108 G--GGIRSLN--VALRQELDLYVCLRPVRYYQGT--PSPVK-HPELTDMVIFRENSEDIYAGIEWKADSADAEKvikflr 180
Cdd:pfam00180 76 WdpAGVRPENglLALRKELGLFANLRPAKVFPPLgdASPLKnEVEGVDIVIVRELTGGIYFGIEKGIKGSGNEV------ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 181 eemgvkkirfpehcGIGIKPCSEEGTKRLVRAAIEYAITNDRESVTLVHKGNIMKFTEGaFKDWGYQLAREEFGgelidg 260
Cdd:pfam00180 150 --------------AVDTKLYSRDEIERIARVAFELARKRGRKKVTSVDKANVLKSSDL-WRKIVTEVAKAEYP------ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 261 gpwvkiknpnngkEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC-ALFEATH 339
Cdd:pfam00180 209 -------------DVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFGDILSDEASMLTGSLGLLPSASLGANGfGIFEPVH 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495124531 340 GTAPKYAGQDKVNPGSIILSAEMMLRH-MGWFEAADLIVKGMEGAINNKTVTYDferLMEGAKLLKCSEFGDAI 412
Cdd:pfam00180 276 GSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKVLESGIRTGD---LAGSATYVSTSEFGEAV 346
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07006 |
PRK07006 |
isocitrate dehydrogenase; Reviewed |
8-416 |
0e+00 |
|
isocitrate dehydrogenase; Reviewed
Pssm-ID: 180792 Cd Length: 409 Bit Score: 910.21 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 8 PAEGAKITAQNGKLNVPHNPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQLYGQDVWLPQE 87
Cdd:PRK07006 1 PAEGEKITVNNGKLNVPNNPIIPFIEGDGIGPDITPAMLKVVDAAVEKAYKGERKISWMEIYAGEKATKVYGEDVWLPEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKA 167
Cdd:PRK07006 81 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVKRPEDTDMVIFRENSEDIYAGIEWKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 168 DSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAITNDRESVTLVHKGNIMKFTEGAFKDWGYQ 247
Cdd:PRK07006 161 GSAEAKKVIKFLQEEMGVKKIRFPETSGIGIKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 248 LAREEFGGELIDGGPWVKIKNPNNGKEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327
Cdd:PRK07006 241 LAEEEFGDELIDGGPWDKIKNPETGKEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGAN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWFEAADLIVKGMEGAINNKTVTYDFERLMEGAKLLKCSE 407
Cdd:PRK07006 321 INDGHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIASKTVTYDFARLMEGATEVKCSE 400
|
....*....
gi 495124531 408 FGDAIIANM 416
Cdd:PRK07006 401 FGDALIKNM 409
|
|
| prok_nadp_idh |
TIGR00183 |
isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent ... |
1-416 |
0e+00 |
|
isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; Prokaryotic NADP-dependent isocitrate dehydrogenases resemble their NAD-dependent counterparts and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent isocitrate dehydrogenases. [Energy metabolism, TCA cycle]
Pssm-ID: 272948 Cd Length: 416 Bit Score: 826.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 1 MESKVVVPAEGAKITAQNGKLNVPHNPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQLYGQ 80
Cdd:TIGR00183 1 MYEKVKPPAQGEKITYENGKLNVPNNPIIPYIEGDGIGVDVTPAAIKVLDAAVEKAYKGEKKIVWFEVYAGEKAYQLYGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 81 DVWLPQETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIY 160
Cdd:TIGR00183 81 DQWLPADTLDAIKEYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYKGVPSPVKHPEKVDMVIFRENTEDIY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 161 AGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAITNDRESVTLVHKGNIMKFTEGA 240
Cdd:TIGR00183 161 AGIEWAEGSEEAKKLIRFLQNELGVKKIRFPEDSGIGIKPISEEGTKRLVRAAIEYAIENDRKSVTLVHKGNIMKFTEGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 241 FKDWGYQLAREEFGGELIDGGPWVKIKNPNNGKEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320
Cdd:TIGR00183 241 FRDWGYELAKKEFGAECITWGLWDKYKNPNPGKEIVIKDRIADAFLQQILTRPDEYDVIATMNLNGDYISDALAAQVGGI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWFEAADLIVKGMEGAINNKTVTYDFERLMEGA 400
Cdd:TIGR00183 321 GIAPGANIGDEIGIFEATHGTAPKYAGQDKVNPGSIILSGEMMLEHMGWKEAADLIKKAMEKAIASKIVTYDFARLMDGA 400
|
410
....*....|....*.
gi 495124531 401 KLLKCSEFGDAIIANM 416
Cdd:TIGR00183 401 KEVKCSEFAEAIIENM 416
|
|
| Icd |
COG0538 |
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ... |
10-416 |
0e+00 |
|
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304 Cd Length: 409 Bit Score: 793.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 10 EGAKITAQNGKLNVPHNPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQLYGQdvWLPQETL 89
Cdd:COG0538 2 EGEKIKVEDGKLKVPDNPIIPFIEGDGIGPEITRAIWKVIDAAVEKAYGGKRDIEWKEVDAGEKARDETGD--WLPDETA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 90 DLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADS 169
Cdd:COG0538 80 EAIKEYGVGIKGPLTTPVGGGWRSLNVTIRQILDLYVCRRPVRYFKGVPSPVKHPEKVDIVIFRENTEDIYAGIEWKAGS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 170 ADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAITNDRESVTLVHKGNIMKFTEGAFKDWGYQLA 249
Cdd:COG0538 160 PEALKLIFFLEDEMGVTVIRFPEDSGIGIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 250 REEFGGELIDGGPWVKIKNPNNGKEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIG 329
Cdd:COG0538 240 EEEFGDKFITEGPWEKYKGPKPAGKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 330 DEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWFEAADLIVKGMEGAINNKTVTYDFERLMEGAKLLKCSEF 408
Cdd:COG0538 320 DDGgAEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKVTYDLARLMEGATELSTSEF 399
|
....*...
gi 495124531 409 GDAIIANM 416
Cdd:COG0538 400 GDAIIENL 407
|
|
| PRK07362 |
PRK07362 |
NADP-dependent isocitrate dehydrogenase; |
1-415 |
0e+00 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 180944 Cd Length: 474 Bit Score: 570.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 1 MESKVVVPAEGAKITAQNGKLNVPHNPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQLYGQ 80
Cdd:PRK07362 3 MYEKLTPPSTGSKITFKNGKPVVPDNPIIPFIRGDGTGVDIWPATQKVLDAAVAKAYGGERKINWFKVYAGDEACDLYGT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 81 DVWLPQETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIY 160
Cdd:PRK07362 83 YQYLPEDTLEAIREYGVAIKGPLTTPIGGGIRSLNVALRQIFDLYSCVRPCRYYAGTPSPHKNPEKLDVIVYRENTEDIY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 161 AGIEWKADSADAEKVIKFLREEM-----GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIT--NDRESVTLVHKGNI 233
Cdd:PRK07362 163 MGIEWEAGDEIGDKLIKHLNEEVipaspELGKRQIPLGSGIGIKPVSKTGSQRHIRRAIEHALRlpGDKRHVTLVHKGNI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 234 MKFTEGAFKDWGYQLAREEFGGELI-DGGPWV---KIKNPN--------------------------------------- 270
Cdd:PRK07362 243 MKYTEGAFRDWGYELATTEFRDECVtERESWIlsnKEKNPNisiednarmiepgydsltpekkaaicaevkevldsiwss 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 271 --NGK---EIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKY 345
Cdd:PRK07362 323 hgNGKwkeKVLVDDRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFEATHGTAPKH 402
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495124531 346 AGQDKVNPGSIILSAEMMLRHMGWFEAADLIVKGMEGAINNKTVTYDFERLMEGA-KLLKCSEFGDAIIAN 415
Cdd:PRK07362 403 AGLDRINPGSVILSGVMMLEYLGWQEAADLITKGLSAAIANKQVTYDLARLMEPPvDPLSCSEFAEAIISH 473
|
|
| PRK06451 |
PRK06451 |
NADP-dependent isocitrate dehydrogenase; |
7-416 |
5.49e-161 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 235803 Cd Length: 412 Bit Score: 459.30 E-value: 5.49e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 7 VPAEGAKITAQNGKLNVPHNPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQLYGQDvwLPQ 86
Cdd:PRK06451 4 IPEDGEVIKFENGKWIVPKKPIILYVEGDGIGPEITHAAMKVINKAVEKAYGSDREIKWVEVLAGDKAEKLTGNR--FPK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWK 166
Cdd:PRK06451 82 ESEELIEKYRVLLKGPLETPIGKGWKSINVAIRLMLDLYANIRPVKYIPGIESPLKNPEKIDLIIFRENTDDLYRGIEYP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 167 ADSADAEKVIKFLREEMGVKkirFPEHCGIGIKPCSEEGTKRLVRAAIEYAITNDRESVTLVHKGNIMKFTEGAFKDWGY 246
Cdd:PRK06451 162 YDSEEAKKIRDFLRKELGVE---VEDDTGIGIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 247 QLAREEFGGELIDGGPWVKIKN--PNNGKeIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324
Cdd:PRK06451 239 EVALKEFRDYVVTEEEVTKNYNgvPPSGK-VIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWFEAADLIVKGMEGAINNKTVTYDFERLMeGAKLLK 404
Cdd:PRK06451 318 GANIGDTGGMFEAIHGTAPKYAGKNVANPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQKKVTQDLARFM-GVRALS 396
|
410
....*....|..
gi 495124531 405 CSEFGDAIIANM 416
Cdd:PRK06451 397 TTEYTDELISII 408
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
28-412 |
1.27e-110 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 328.48 E-value: 1.27e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 28 IIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKgerKISWMEIYTGEKSTQLYGQdvWLPQETLDLIREYRVAIKGPLTTPV 107
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPL---EFEFEERDVGGAAIDETGE--PLPDETLEACKKADAVLLGAVGGPK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 108 G--GGIRSLN--VALRQELDLYVCLRPVRYYQGT--PSPVK-HPELTDMVIFRENSEDIYAGIEWKADSADAEKvikflr 180
Cdd:pfam00180 76 WdpAGVRPENglLALRKELGLFANLRPAKVFPPLgdASPLKnEVEGVDIVIVRELTGGIYFGIEKGIKGSGNEV------ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 181 eemgvkkirfpehcGIGIKPCSEEGTKRLVRAAIEYAITNDRESVTLVHKGNIMKFTEGaFKDWGYQLAREEFGgelidg 260
Cdd:pfam00180 150 --------------AVDTKLYSRDEIERIARVAFELARKRGRKKVTSVDKANVLKSSDL-WRKIVTEVAKAEYP------ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 261 gpwvkiknpnngkEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC-ALFEATH 339
Cdd:pfam00180 209 -------------DVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFGDILSDEASMLTGSLGLLPSASLGANGfGIFEPVH 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495124531 340 GTAPKYAGQDKVNPGSIILSAEMMLRH-MGWFEAADLIVKGMEGAINNKTVTYDferLMEGAKLLKCSEFGDAI 412
Cdd:pfam00180 276 GSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKVLESGIRTGD---LAGSATYVSTSEFGEAV 346
|
|
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
32-416 |
5.74e-106 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 316.57 E-value: 5.74e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 32 IEGDGIGVDVTPAMLKVVDAAvekAYKGERKISWMEIYTGEKSTQLYGQDvwLPQETLDLIREYRVAIKGPLTTPV---G 108
Cdd:COG0473 7 LPGDGIGPEVVAAALKVLEAA---AERFGLDFEFEEADIGGAAYDKTGTP--LPDETLEALRKADAILLGAVGGPKwddG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 109 GGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVikflreemgvk 186
Cdd:COG0473 82 VRPESGLLALRKELDLYANLRPAKLYPGLPSPLKPeiVEGIDLVIVRENTEGLYFGIGGRIGTGTGEEV----------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 187 kirfpehcGIGIKPCSEEGTKRLVRAAIEYAITNdRESVTLVHKGNIMKFTEGAFKDWGYQLAREefggelidggpwvki 266
Cdd:COG0473 151 --------AIDTRVYTRKGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKE--------------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 267 kNPnngkEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKY 345
Cdd:COG0473 207 -YP----DVELDHMYVDAAAMQLVRNPEQFDVIVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEPVHGSAPDI 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495124531 346 AGQDKVNPGSIILSAEMMLRHMGWFEAADLIVKGMEGAINNKTVTYDferLMEGAkllKCSEFGDAIIANM 416
Cdd:COG0473 282 AGKGIANPIATILSAAMMLRHLGEEEAADAIEAAVEKVLAEGVRTPD---LGGKA---GTSEMGDAIIAAL 346
|
|
| PRK09222 |
PRK09222 |
NADP-dependent isocitrate dehydrogenase; |
29-416 |
8.95e-84 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236416 [Multi-domain] Cd Length: 482 Bit Score: 264.45 E-value: 8.95e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 29 IPFIEGDGIGVDVTPAMLKVVDAAvekaykgERKISWMEIYTGEKstqLY--GQDVWLPQETLDLIREYRVAIKGPLTTP 106
Cdd:PRK09222 7 ITVAYGDGIGPEIMEAVLKILEAA-------GAPLEIETIEIGEK---VYkkGWTSGISPSAWESIRRTKVLLKAPITTP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 107 VGGGIRSLNVALRQELDLYVCLRPVRYYqgtpSPV---KHPELtDMVIFRENSEDIYAGIEWK--ADSADAEKVIkflre 181
Cdd:PRK09222 77 QGGGYKSLNVTLRKTLGLYANVRPCVSY----HPFvetKHPNL-DVVIIRENEEDLYAGIEHRqtPDVYQCLKLI----- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 182 emgvkkirfpehcgigikpcSEEGTKRLVRAAIEYAITNDRESVTLVHKGNIMKFTEGAFKDWGYQLAREEfggelidgg 261
Cdd:PRK09222 147 --------------------SRPGSEKIIRYAFEYARANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEY--------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 262 PwvkiknpnngkEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDaLAAQV-GGIGIAPGANIGDECALFEATHG 340
Cdd:PRK09222 198 P-----------DIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSD-IAAEIsGSVGLAGSANIGEEYAMFEAVHG 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 341 TAPKYAGQDKVNPGSIILSAEMMLRHMGWFEAADLI----VKGMEGAINnktvTYDFERLMEGAKLLKCSEFGDAIIANM 416
Cdd:PRK09222 266 SAPDIAGKNIANPSGLLNAAVMMLVHIGQFDIAELIenawLKTLEDGIH----TADIYNEGVSKKKVGTKEFAEAVIENL 341
|
|
| PRK08997 |
PRK08997 |
isocitrate dehydrogenase; Provisional |
29-390 |
2.54e-77 |
|
isocitrate dehydrogenase; Provisional
Pssm-ID: 181606 Cd Length: 334 Bit Score: 243.09 E-value: 2.54e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 29 IPFIEGDGIGVDVTPAMLKVVDAA-----VEKAYKGERKIswmeiytgEKSTQLygqdvwLPQETLDLIREYRVAIKGPL 103
Cdd:PRK08997 5 ITVIPGDGIGPSIIDATLKILDKLgcdfeYEFADAGLTAL--------EKHGEL------LPQRTLDLIEKNKIALKGPL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 104 TTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVkhpELTDMVIFRENSEDIYAGI--EWKADSADAEKVIKFLRE 181
Cdd:PRK08997 71 TTPVGEGFTSINVTLRKKFDLYANVRPVLSFPGTKARY---DNIDIITVRENTEGMYSGEgqTVSEDGETAEATSIITRK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 182 emgvkkirfpehcgigikpcseeGTKRLVRAAIEYAITNDRESVTLVHKGNIMKFTEGAFKDwgyqLAREefggelidgg 261
Cdd:PRK08997 148 -----------------------GAERIVRFAYELARKEGRKKVTAVHKANIMKSTSGLFLK----VARE---------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 262 pwVKIKNPnngkEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGT 341
Cdd:PRK08997 191 --VALRYP----DIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGLVGGLGMAPGANIGRDAAIFEAVHGS 264
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 495124531 342 APKYAGQDKVNPGSIILSAEMMLRHMGWFEAADLIVKGMEGAINNKTVT 390
Cdd:PRK08997 265 APDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRT 313
|
|
| mito_nad_idh |
TIGR00175 |
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ... |
31-416 |
4.83e-68 |
|
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]
Pssm-ID: 272942 Cd Length: 333 Bit Score: 218.79 E-value: 4.83e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 31 FIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEkstqlygqdvwLPQETLDLIREYRVAIKGPLTTPVG-G 109
Cdd:TIGR00175 8 LIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKTE-----------IPDEAVESIKRNKVALKGPLETPIGkG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 110 GIRSLNVALRQELDLYVCLRPVRYYQGTPSPvkHPELtDMVIFRENSEDIYAGIEwkadsadAEKVikflreeMGVKKir 189
Cdd:TIGR00175 77 GHRSLNVALRKELDLYANVVHCKSLPGFKTR--HEDV-DIVIIRENTEGEYSGLE-------HESV-------PGVVE-- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 190 fpehcgiGIKPCSEEGTKRLVRAAIEYAITNDRESVTLVHKGNIMKFTEGAFKDWGYQLAREEfggelidggpwvkiknp 269
Cdd:TIGR00175 138 -------SLKVITRDKSERIARYAFEYARKNGRKKVTAVHKANIMKLADGLFLNVCREVAKEY----------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 270 nngKEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFE-ATHGTAPKYAGQ 348
Cdd:TIGR00175 194 ---PDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVGGPGLVPGANIGRDYAVFEpGVRHTGPDIAGQ 270
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 495124531 349 DKVNPGSIILSAEMMLRHMGWFEAADLIVKGMEGAI-NNKTVTYDFerlmegAKLLKCSEFGDAIIANM 416
Cdd:TIGR00175 271 NIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIaEGKNRTKDL------GGTATTSDFTEAVIKRL 333
|
|
| PRK14025 |
PRK14025 |
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional |
29-413 |
1.93e-62 |
|
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
Pssm-ID: 184462 Cd Length: 330 Bit Score: 204.21 E-value: 1.93e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 29 IPFIEGDGIGVDVTPAMLKVVdaaveKAYKGERKISWMEiyTGEKSTQLYGqdVWLPQETLDLIREYRVAIKGPLTTPVG 108
Cdd:PRK14025 4 ICVIEGDGIGKEVVPAALHVL-----EATGLPFEFVYAE--AGDEVFEKTG--KALPEETIEAAKEADAVLFGAAGETAA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 109 GGIrslnVALRQELDLYVCLRPVRYYQGTPSpvKHPELtDMVIFRENSEDIYAGIEWKADS--ADAEKVIkflreemgvk 186
Cdd:PRK14025 75 DVI----VKLRRILDTYANVRPVKSYKGVKC--LYPDI-DYVIVRENTEGLYKGIEAEIADgvTVATRVI---------- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 187 kirfpehcgigikpcSEEGTKRLVRAAIEYA----ITNDRESVTLVHKGNIMKFTEGAFKDWGYQLAREEfggelidggp 262
Cdd:PRK14025 138 ---------------TRKASERIFRFAFEMAkrrkKMGKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEY---------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 263 wvkiknpnngKEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTA 342
Cdd:PRK14025 193 ----------PDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGLVGGLGLAPSANIGDKYGLFEPVHGSA 262
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 495124531 343 PKYAGQDKVNPGSIILSAEMMLRHMGWFEAADLIVKGMEGAINNKTVTYDFerlmeGAKlLKCSEFGDAII 413
Cdd:PRK14025 263 PDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGLTTPDL-----GGN-LSTMEMAEEVA 327
|
|
| PLN00118 |
PLN00118 |
isocitrate dehydrogenase (NAD+) |
34-416 |
3.11e-58 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215062 Cd Length: 372 Bit Score: 194.71 E-value: 3.11e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 34 GDGIGVDVTPAMLKVVDAAvekaykgERKISWMEIYTGEKSTQLYGQdvWLPQETLDLIREYRVAIKGPLTTPVGGGIRS 113
Cdd:PLN00118 49 GDGIGPEIAESVKQVFTAA-------GVPIEWEEHYVGTTVDPRTGS--FLTWESLESVRRNKVGLKGPMATPIGKGHRS 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 114 LNVALRQELDLYVCLRPVRYYQGTPSPVKHpelTDMVIFRENSEDIYAGIEwkadsadaEKVIKFLREEmgvkkirfpeh 193
Cdd:PLN00118 120 LNLTLRKELGLYANVRPCYSLPGYKTRYDD---VDLVTIRENTEGEYSGLE--------HQVVRGVVES----------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 194 cgigIKPCSEEGTKRLVRAAIEYAITNDRESVTLVHKGNIMKFTEGAFkdwgYQLAREefggelidggpwVKIKNPnngk 273
Cdd:PLN00118 178 ----LKIITRQASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLF----LKCCRE------------VAEKYP---- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 274 EIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDE-CALFEATHGTAPKYAGQDKVN 352
Cdd:PLN00118 234 EIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIGENgLALAEAVHGSAPDIAGKNLAN 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 495124531 353 PGSIILSAEMMLRHMGWFEAADLIVKGMEGAI-NNKTVTYDFerlmeGAKlLKCSEFGDAIIANM 416
Cdd:PLN00118 314 PTALLLSAVMMLRHLKLNEQAEQIHNAILNTIaEGKYRTADL-----GGS-STTTDFTKAICDHL 372
|
|
| PLN00123 |
PLN00123 |
isocitrate dehydrogenase (NAD+) |
28-416 |
4.90e-53 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215065 Cd Length: 360 Bit Score: 180.83 E-value: 4.90e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 28 IIPFIEGDGIGVDVTPAMLKVVDAAVEKAYkgerkiswMEIYtgekstQLYGQDVWLPQETLDLIREYRVAIKGPLTTPV 107
Cdd:PLN00123 32 AVTLIPGDGIGPLVTGAVEQVMEAMHAPVY--------FERY------EVHGDMKKVPEEVLESIRRNKVCLKGGLATPV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 108 GGGIRSLNVALRQELDLYVCLrpVRYYQGTPSPVKHPELtDMVIFRENSEDIYAGIEwkadsadaEKVIKFLREEMGVKK 187
Cdd:PLN00123 98 GGGVSSLNVQLRKELDLFASL--VNCFNLPGLPTRHENV-DIVVIRENTEGEYSGLE--------HEVVPGVVESLKVIT 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 188 irfpehcgigiKPCSEegtkRLVRAAIEYAITNDRESVTLVHKGNIMKFTEGAFKDWGYQLAReefggelidggpwvkiK 267
Cdd:PLN00123 167 -----------KFCSE----RIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAK----------------K 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 268 NPNngkeIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFE--ATHGTA--P 343
Cdd:PLN00123 216 YPG----IKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEqgASAGNVgnE 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 495124531 344 KYAGQDKVNPGSIILSAEMMLRHMGWFEAADLIVKGMEGAINN-KTVTYDferlMEGAKLLKcsEFGDAIIANM 416
Cdd:PLN00123 292 KLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEgKYRTKD----LGGSSTTQ--EVVDAVIANL 359
|
|
| PRK03437 |
PRK03437 |
3-isopropylmalate dehydrogenase; Provisional |
32-416 |
9.10e-53 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 179579 Cd Length: 344 Bit Score: 179.35 E-value: 9.10e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 32 IEGDGIGVDVTPAMLKVVDAAVEKAYK---------GERkisWMEiyTGEKstqlygqdvwLPQETLDLIREYRVAIKGP 102
Cdd:PRK03437 10 IPGDGIGPEVVAEALKVLDAVAAGGPGvetteydlgARR---YLR--TGET----------LPDSVLAELRQHDAILLGA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 103 LTTP-VGGGI--RSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEwkadsadaekvikfl 179
Cdd:PRK03437 75 IGDPsVPSGVleRGLLLKLRFALDHYVNLRPSKLYPGVTSPLAGPGDIDFVVVREGTEGPYTGNG--------------- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 180 reemGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAITNDRESVTLVHKGNIMKFtegAFKDWgyQLAREEFGGELid 259
Cdd:PRK03437 140 ----GALRVGTPHEVATEVSVNTAFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTF---AGDLW--QRTVDEVAAEY-- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 260 ggpwvkiknPnngkEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI---GDECALFE 336
Cdd:PRK03437 209 ---------P----DVTVDYQHVDAATIFMVTDPSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNInptGTNPSMFE 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 337 ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWFEAADLIvkgmEGAinnktVTYDFERLMEGAklLKCSEFGDAIIANM 416
Cdd:PRK03437 276 PVHGSAPDIAGQGIADPTAAILSVALLLDHLGEEDAAARI----EAA-----VEADLAERGKMG--RSTAEVGDRIAARL 344
|
|
| PRK00772 |
PRK00772 |
3-isopropylmalate dehydrogenase; Provisional |
32-416 |
1.03e-44 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 234832 Cd Length: 358 Bit Score: 158.73 E-value: 1.03e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 32 IEGDGIGVDVTPAMLKVVDAAvekAYKGERKISWMEIYTGEKSTQLYGqdVWLPQETLDLIREYRV----AIKGPLTTPV 107
Cdd:PRK00772 8 LPGDGIGPEVMAEAVKVLDAV---AEKFGFDFEFEEALVGGAAIDAHG--VPLPEETLEACRAADAvllgAVGGPKWDNL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 108 GGGIRSLN--VALRQELDLYVCLRPVRYYQG--TPSPVKhPEL---TDMVIFRENSEDIYAGiewkadsaDAEKVIKFLR 180
Cdd:PRK00772 83 PPDVRPERglLALRKELGLFANLRPAKLYPGlaDASPLK-PEIvagLDILIVRELTGGIYFG--------EPRGREGLGG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 181 EEMGVKKIRFpehcgigikpcSEEGTKRLVRAAIEYAITNdRESVTLVHKGNIMKFTegafkdwgyQLAREEFGgelidg 260
Cdd:PRK00772 154 EERAFDTMVY-----------TREEIERIARVAFELARKR-RKKVTSVDKANVLESS---------RLWREVVT------ 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 261 gpWVKIKNPnngkEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC-ALFEATH 339
Cdd:PRK00772 207 --EVAKEYP----DVELSHMYVDNAAMQLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESGpGLYEPIH 280
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 495124531 340 GTAPKYAGQDKVNPGSIILSAEMMLRH-MGWFEAADLIVKGMEGAINNKTVTYDferLMEGAKLLKCSEFGDAIIANM 416
Cdd:PRK00772 281 GSAPDIAGKGIANPIATILSAAMMLRYsLGLEEAADAIEAAVEKVLAQGYRTAD---IAEGGGKVSTSEMGDAILAAL 355
|
|
| PRK08194 |
PRK08194 |
tartrate dehydrogenase; Provisional |
29-392 |
4.11e-38 |
|
tartrate dehydrogenase; Provisional
Pssm-ID: 181281 Cd Length: 352 Bit Score: 141.01 E-value: 4.11e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 29 IPFIEGDGIGVDVTPAMLKVVDAAVEkaYKGERKISWMEIYTGEKSTQLYGQdvWLPQETLDLIREYRV----AIKGPLT 104
Cdd:PRK08194 6 IAVIPGDGVGKEVVPAAVRVLKAVAE--VHGGLKFEFTEFPWSCEYYLEHGE--MMPEDGLEQLKQFDAiflgAVGNPKL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 105 TPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAgiewkadsadaekvikflreEMG 184
Cdd:PRK08194 82 VPDHISLWGLLIKIRREFEQVINIRPAKQLRGIKSPLANPKDFDLLVVRENSEGEYS--------------------EVG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 185 VKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAiTNDRESVTLVHKGN----IMKFTEGAFKDWGyqlarEEFggelidg 260
Cdd:PRK08194 142 GRIHRGEDEIAIQNAVFTRKGTERAMRYAFELA-AKRRKHVTSATKSNgivhSMPFWDEVFQEVG-----KDY------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 261 gpwvkiknpnngKEIVVKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI---GDECALFEA 337
Cdd:PRK08194 209 ------------PEIETDSQHIDALAAFFVTRPEEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANInvnGKYPSMFEP 276
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 495124531 338 THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWFEAADLIVKGMEGAINNKTVTYD 392
Cdd:PRK08194 277 VHGSAPDIAGKGIANPIGQIWTAKLMLDHFGEEELGSHLLDVIEDVTEDGIKTPD 331
|
|
| PLN02329 |
PLN02329 |
3-isopropylmalate dehydrogenase |
29-416 |
5.20e-18 |
|
3-isopropylmalate dehydrogenase
Pssm-ID: 215188 Cd Length: 409 Bit Score: 85.12 E-value: 5.20e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 29 IPFIEGDGIGvdvtPAMLKVVDAAVEKA-YKGERKISWMEIYTGEKSTQLYGqdVWLPQETLDLIREYRVAIKGPlttpV 107
Cdd:PLN02329 49 IALLPGDGIG----PEVISVAKNVLQKAgSLEGLEFDFQEMPVGGAALDLVG--VPLPEETFTAAKQSDAILLGA----I 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 108 GGGIRSLN----------VALRQELDLYVCLRPV----RYYQGTPSPVKHPELTDMVIFRENSEDIYAGiewkadsadae 173
Cdd:PLN02329 119 GGYKWDKNekhlrpemalFYLRRDLKVFANLRPAtvlpQLVDASTLKKEVAEGVDMMIVRELTGGIYFG----------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 174 kvikflrEEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAiTNDRESVTLVHKGNIMKftegAFKDWGYQLAreef 253
Cdd:PLN02329 188 -------EPRGITINENGEEVGVSTEIYAAHEIDRIARVAFETA-RKRRGKLCSVDKANVLD----ASILWRKRVT---- 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 254 ggELIDGGPWVKIKNpnngkeivvkdVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC- 332
Cdd:PLN02329 252 --ALASEYPDVELSH-----------MYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGp 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 495124531 333 ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWFEAADLIVKGMEGAINNKTVTYDFerLMEGAKLLKCSEFGDA 411
Cdd:PLN02329 319 GLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKRIEDAVVDALNKGFRTGDI--YSPGNKLVGCKEMGEE 396
|
....*
gi 495124531 412 IIANM 416
Cdd:PLN02329 397 VLKSV 401
|
|
| |
