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Conserved domains on  [gi|496412593|ref|WP_009121457|]
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MULTISPECIES: HIT family protein [Bacteroides]

Protein Classification

HIT family protein( domain architecture ID 10001677)

HIT (Histidine triad) family protein, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), is part of a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides

CATH:  3.30.428.10
Gene Ontology:  GO:1904047
PubMed:  1472710|9323207|12504684|12119013
SCOP:  3000223

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HinT COG0537
Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide ...
 7-139 4.44e-26

Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide transport and metabolism, General function prediction only];


:

Pssm-ID: 440303 [Multi-domain]  Cd Length: 133  Bit Score: 95.02  E-value: 4.44e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496412593   7 ECLYCQ--NNETLHNLmieIAQLSVSRVFLFKEQTYRGRCLVAYKDHVNDLNELSDEERNAFMADVARVTRAMQKAFNPE 84
Cdd:COG0537    2 DCIFCKiiAGEIPALI---VYEDEHVLAFLDINPYAPGHTLVIPKRHVASLFDLTPEELAELMRLAQKVAKALRKALGPD 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 496412593  85 KINYGAYSDKLS-----HLHFHLAPKYVdgpdyGGTFQMNPGKVYLTDAEYQELIEAVRS 139
Cdd:COG0537   79 GFNLGINNGEAAgqtvpHLHVHVIPRYE-----GDDNFMPVIGTKVDPEELEETARKLRA 133
 
Name Accession Description Interval E-value
HinT COG0537
Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide ...
 7-139 4.44e-26

Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide transport and metabolism, General function prediction only];


Pssm-ID: 440303 [Multi-domain]  Cd Length: 133  Bit Score: 95.02  E-value: 4.44e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496412593   7 ECLYCQ--NNETLHNLmieIAQLSVSRVFLFKEQTYRGRCLVAYKDHVNDLNELSDEERNAFMADVARVTRAMQKAFNPE 84
Cdd:COG0537    2 DCIFCKiiAGEIPALI---VYEDEHVLAFLDINPYAPGHTLVIPKRHVASLFDLTPEELAELMRLAQKVAKALRKALGPD 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 496412593  85 KINYGAYSDKLS-----HLHFHLAPKYVdgpdyGGTFQMNPGKVYLTDAEYQELIEAVRS 139
Cdd:COG0537   79 GFNLGINNGEAAgqtvpHLHVHVIPRYE-----GDDNFMPVIGTKVDPEELEETARKLRA 133
HINT_subgroup cd01277
HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the ...
 32-105 1.92e-11

HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life. Although the biochemical function has not been characterised for many of the members of this subgroup, the proteins from Yeast have been shown to be involved in secretion, peroxisome formation and gene expression.


Pssm-ID: 238608 [Multi-domain]  Cd Length: 103  Bit Score: 56.85  E-value: 1.92e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 496412593  32 VFLFKEQTYRGRCLVAYKDHVNDLNELSDEERNAFMADVARVTRAMQKAFNPEKINYGAYSDKLS-----HLHFHLAPK 105
Cdd:cd01277   25 AFLDINPASKGHTLVIPKKHYENLLDLDPEELAELILAAKKVARALKKALKADGLNILQNNGRAAgqvvfHVHVHVIPR 103
HIT pfam01230
HIT domain;
30-106 2.27e-08

HIT domain;


Pssm-ID: 395984 [Multi-domain]  Cd Length: 98  Bit Score: 48.46  E-value: 2.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496412593   30 SRVFLFKEQTYRGRCLVAYKDHVNDLNELSDEERNAFMADVARVTRAMQKAFNPE-----KINYGAYSDKLSHLHFHLAP 104
Cdd:pfam01230  15 VLAFLDIDPQAPGHILVIPKKHIRELHDLTPEELGDLMSVAQKVARALGKVFKADgyrivINNGAHAGQSVPHLHIHVIP 94


                  ..
gi 496412593  105 KY 106
Cdd:pfam01230  95 RR 96
 
Name Accession Description Interval E-value
HinT COG0537
Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide ...
 7-139 4.44e-26

Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide transport and metabolism, General function prediction only];


Pssm-ID: 440303 [Multi-domain]  Cd Length: 133  Bit Score: 95.02  E-value: 4.44e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496412593   7 ECLYCQ--NNETLHNLmieIAQLSVSRVFLFKEQTYRGRCLVAYKDHVNDLNELSDEERNAFMADVARVTRAMQKAFNPE 84
Cdd:COG0537    2 DCIFCKiiAGEIPALI---VYEDEHVLAFLDINPYAPGHTLVIPKRHVASLFDLTPEELAELMRLAQKVAKALRKALGPD 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 496412593  85 KINYGAYSDKLS-----HLHFHLAPKYVdgpdyGGTFQMNPGKVYLTDAEYQELIEAVRS 139
Cdd:COG0537   79 GFNLGINNGEAAgqtvpHLHVHVIPRYE-----GDDNFMPVIGTKVDPEELEETARKLRA 133
HINT_subgroup cd01277
HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the ...
 32-105 1.92e-11

HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life. Although the biochemical function has not been characterised for many of the members of this subgroup, the proteins from Yeast have been shown to be involved in secretion, peroxisome formation and gene expression.


Pssm-ID: 238608 [Multi-domain]  Cd Length: 103  Bit Score: 56.85  E-value: 1.92e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 496412593  32 VFLFKEQTYRGRCLVAYKDHVNDLNELSDEERNAFMADVARVTRAMQKAFNPEKINYGAYSDKLS-----HLHFHLAPK 105
Cdd:cd01277   25 AFLDINPASKGHTLVIPKKHYENLLDLDPEELAELILAAKKVARALKKALKADGLNILQNNGRAAgqvvfHVHVHVIPR 103
HIT pfam01230
HIT domain;
30-106 2.27e-08

HIT domain;


Pssm-ID: 395984 [Multi-domain]  Cd Length: 98  Bit Score: 48.46  E-value: 2.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496412593   30 SRVFLFKEQTYRGRCLVAYKDHVNDLNELSDEERNAFMADVARVTRAMQKAFNPE-----KINYGAYSDKLSHLHFHLAP 104
Cdd:pfam01230  15 VLAFLDIDPQAPGHILVIPKKHIRELHDLTPEELGDLMSVAQKVARALGKVFKADgyrivINNGAHAGQSVPHLHIHVIP 94


                  ..
gi 496412593  105 KY 106
Cdd:pfam01230  95 RR 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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