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Conserved domains on  [gi|497337628|ref|WP_009651841|]
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MULTISPECIES: GyrI-like domain-containing protein [Klebsiella]

Protein Classification

GyrI-like domain-containing protein( domain architecture ID 10007405)

GyrI-like domain-containing protein adopts a beta-barrel fold similar to the effector-binding region of AraC/XylS transcription activators and may bind a small molecule; similar to Escherichia coli probable transcriptional regulator YgiV

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SbmC COG3449
DNA gyrase inhibitor GyrI/SbmC [Replication, recombination and repair];
13-289 1.13e-78

DNA gyrase inhibitor GyrI/SbmC [Replication, recombination and repair];


:

Pssm-ID: 442672 [Multi-domain]  Cd Length: 286  Bit Score: 240.14  E-value: 1.13e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  13 RFQQVCLYIERHLDTPLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRACWRLAFNPQEKIIDIALDAGFQN 92
Cdd:COG3449   12 RRRILLVLIALHDDLDLLLLALLLAFAFHFFFFHRRRRFRALIGRRARLLLRRRLLAALALLLLSSSAIIAAAAAASGYS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  93 PESFSRAFRSAFAQSPSQFRQQPDWLEWHRRvPKHTLQEQHPMDVKIIQLPTTQIARLRHRGNPDLVNETAAKFIAWRKV 172
Cdd:COG3449   92 SSASFRRFFRAFGGSSRSRRRRAKAKLLALP-PLDPPRLEPMMDVEIKELPPRRVAYLRHRGPYEEIGEAFERLIAWAKA 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628 173 SGLSPvASCATWGISWDDPAATPADDFRFDIGGTVSQPVPEnSFGVVNGEIPGGRCAVVRHHGSLDTLAQSIWFLYRDWL 252
Cdd:COG3449  171 RGLLP-PDSRTIGIYYDDPDITPPEKLRYDACVTVPEDVAL-PGGVEVKTIPGGRYAVLRHKGPYEDLGAAWDWLYGEWL 248

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 497337628 253 PASGESLRDFPVFFRYLTFVHEVGEHELQTDVYLPLK 289
Cdd:COG3449  249 PASGYELRDRPCFEIYLNDPRETPEGELITDIYLPLK 285
 
Name Accession Description Interval E-value
SbmC COG3449
DNA gyrase inhibitor GyrI/SbmC [Replication, recombination and repair];
13-289 1.13e-78

DNA gyrase inhibitor GyrI/SbmC [Replication, recombination and repair];


Pssm-ID: 442672 [Multi-domain]  Cd Length: 286  Bit Score: 240.14  E-value: 1.13e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  13 RFQQVCLYIERHLDTPLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRACWRLAFNPQEKIIDIALDAGFQN 92
Cdd:COG3449   12 RRRILLVLIALHDDLDLLLLALLLAFAFHFFFFHRRRRFRALIGRRARLLLRRRLLAALALLLLSSSAIIAAAAAASGYS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  93 PESFSRAFRSAFAQSPSQFRQQPDWLEWHRRvPKHTLQEQHPMDVKIIQLPTTQIARLRHRGNPDLVNETAAKFIAWRKV 172
Cdd:COG3449   92 SSASFRRFFRAFGGSSRSRRRRAKAKLLALP-PLDPPRLEPMMDVEIKELPPRRVAYLRHRGPYEEIGEAFERLIAWAKA 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628 173 SGLSPvASCATWGISWDDPAATPADDFRFDIGGTVSQPVPEnSFGVVNGEIPGGRCAVVRHHGSLDTLAQSIWFLYRDWL 252
Cdd:COG3449  171 RGLLP-PDSRTIGIYYDDPDITPPEKLRYDACVTVPEDVAL-PGGVEVKTIPGGRYAVLRHKGPYEDLGAAWDWLYGEWL 248

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 497337628 253 PASGESLRDFPVFFRYLTFVHEVGEHELQTDVYLPLK 289
Cdd:COG3449  249 PASGYELRDRPCFEIYLNDPRETPEGELITDIYLPLK 285
GyrI-like pfam06445
GyrI-like small molecule binding domain; This family contains the small molecule binding ...
 136-288 3.20e-41

GyrI-like small molecule binding domain; This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.


Pssm-ID: 428947  Cd Length: 153  Bit Score: 139.85  E-value: 3.20e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  136 DVKIIQLPTTQIARLRHRGNPDL--VNETAAKFIAWRKVSGLSPvASCATWGISWDDPAATPADDFRFDIGGTVSQPVpE 213
Cdd:pfam06445   1 EVEIVELPAFRVAGLRHRGPYNEegIGALWEELCAWASENGLSP-APSPLIGVSYDDPEVTEDEELRYDAGVAVPIPV-E 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497337628  214 NSFGVVNGEIPGGRCAVVRHHGSLDTLAQSIWFLYRDWLPASGESLRDFPVFFRYLTFVHEVGEHELQTDVYLPL 288
Cdd:pfam06445  79 GPEGVEELELPGGEYAVFRHKGPYDDLQETYAKIYGEWLPESGYERRDGPSFEIYLNDPREVPEEELKTEIYIPV 153
AraC_E_bind smart00871
Bacterial transcription activator, effector binding domain; This domain is found in the ...
 136-289 2.65e-40

Bacterial transcription activator, effector binding domain; This domain is found in the probable effector binding domain of a number of different bacterial transcription activators.and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.


Pssm-ID: 214874 [Multi-domain]  Cd Length: 158  Bit Score: 137.61  E-value: 2.65e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628   136 DVKIIQLPTTQIARLRHRGNPDL--VNETAAKFIAWRKVSGLSPVASCATW-GISWDDPAATPADDFRFDIGGTVSQPvP 212
Cdd:smart00871   1 EVRIVELPAFKVAGLRHRGPNEDekIPELWQRLIQWAKELGLLPVGNSGEPyGVYYDDPDDTPDGEFRYDAGVEVSDE-V 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497337628   213 ENSFGVVNGEIPGGRCAVVRHHG-SLDTLAQSIWFLYRDWLPASGESLRDFPVFF-RYLTFVHEVGEHELQTDVYLPLK 289
Cdd:smart00871  80 EAPEGVETKTIPAGKYAVFTHKGgSYDEIQEAWEAIYGEWLPNSGYELRDAGPDFeVYLNDPPDTDPEELVTEIYIPVK 158
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
20-147 4.83e-16

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 76.20  E-value: 4.83e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  20 YIERHLDTPLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRAC--WRLAFNPqekIIDIALDAGFQNPESFS 97
Cdd:PRK15121  13 WLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKAAvaLRLTSRP---ILDIALQYRFDSQQTFT 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 497337628  98 RAFRSAFAQSPSQFRQQPDWLEWHRRvPKHTLQEQHPMDVKIIQLPTTQI 147
Cdd:PRK15121  90 RAFKKQFAQTPALYRRSPEWSAFGIR-PPIRLGEFTLPEHEFVTLPETPL 138
 
Name Accession Description Interval E-value
SbmC COG3449
DNA gyrase inhibitor GyrI/SbmC [Replication, recombination and repair];
13-289 1.13e-78

DNA gyrase inhibitor GyrI/SbmC [Replication, recombination and repair];


Pssm-ID: 442672 [Multi-domain]  Cd Length: 286  Bit Score: 240.14  E-value: 1.13e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  13 RFQQVCLYIERHLDTPLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRACWRLAFNPQEKIIDIALDAGFQN 92
Cdd:COG3449   12 RRRILLVLIALHDDLDLLLLALLLAFAFHFFFFHRRRRFRALIGRRARLLLRRRLLAALALLLLSSSAIIAAAAAASGYS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  93 PESFSRAFRSAFAQSPSQFRQQPDWLEWHRRvPKHTLQEQHPMDVKIIQLPTTQIARLRHRGNPDLVNETAAKFIAWRKV 172
Cdd:COG3449   92 SSASFRRFFRAFGGSSRSRRRRAKAKLLALP-PLDPPRLEPMMDVEIKELPPRRVAYLRHRGPYEEIGEAFERLIAWAKA 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628 173 SGLSPvASCATWGISWDDPAATPADDFRFDIGGTVSQPVPEnSFGVVNGEIPGGRCAVVRHHGSLDTLAQSIWFLYRDWL 252
Cdd:COG3449  171 RGLLP-PDSRTIGIYYDDPDITPPEKLRYDACVTVPEDVAL-PGGVEVKTIPGGRYAVLRHKGPYEDLGAAWDWLYGEWL 248

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 497337628 253 PASGESLRDFPVFFRYLTFVHEVGEHELQTDVYLPLK 289
Cdd:COG3449  249 PASGYELRDRPCFEIYLNDPRETPEGELITDIYLPLK 285
GyrI-like pfam06445
GyrI-like small molecule binding domain; This family contains the small molecule binding ...
 136-288 3.20e-41

GyrI-like small molecule binding domain; This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.


Pssm-ID: 428947  Cd Length: 153  Bit Score: 139.85  E-value: 3.20e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  136 DVKIIQLPTTQIARLRHRGNPDL--VNETAAKFIAWRKVSGLSPvASCATWGISWDDPAATPADDFRFDIGGTVSQPVpE 213
Cdd:pfam06445   1 EVEIVELPAFRVAGLRHRGPYNEegIGALWEELCAWASENGLSP-APSPLIGVSYDDPEVTEDEELRYDAGVAVPIPV-E 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497337628  214 NSFGVVNGEIPGGRCAVVRHHGSLDTLAQSIWFLYRDWLPASGESLRDFPVFFRYLTFVHEVGEHELQTDVYLPL 288
Cdd:pfam06445  79 GPEGVEELELPGGEYAVFRHKGPYDDLQETYAKIYGEWLPESGYERRDGPSFEIYLNDPREVPEEELKTEIYIPV 153
AraC_E_bind smart00871
Bacterial transcription activator, effector binding domain; This domain is found in the ...
 136-289 2.65e-40

Bacterial transcription activator, effector binding domain; This domain is found in the probable effector binding domain of a number of different bacterial transcription activators.and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.


Pssm-ID: 214874 [Multi-domain]  Cd Length: 158  Bit Score: 137.61  E-value: 2.65e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628   136 DVKIIQLPTTQIARLRHRGNPDL--VNETAAKFIAWRKVSGLSPVASCATW-GISWDDPAATPADDFRFDIGGTVSQPvP 212
Cdd:smart00871   1 EVRIVELPAFKVAGLRHRGPNEDekIPELWQRLIQWAKELGLLPVGNSGEPyGVYYDDPDDTPDGEFRYDAGVEVSDE-V 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497337628   213 ENSFGVVNGEIPGGRCAVVRHHG-SLDTLAQSIWFLYRDWLPASGESLRDFPVFF-RYLTFVHEVGEHELQTDVYLPLK 289
Cdd:smart00871  80 EAPEGVETKTIPAGKYAVFTHKGgSYDEIQEAWEAIYGEWLPNSGYELRDAGPDFeVYLNDPPDTDPEELVTEIYIPVK 158
HTH_18 pfam12833
Helix-turn-helix domain;
34-114 2.61e-24

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 93.42  E-value: 2.61e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628   34 LSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRACWRLAFNPQEKIIDIALDAGFQNPESFSRAFRSAFAQSPSQFRQ 113
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 497337628  114 Q 114
Cdd:pfam12833  81 R 81
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
28-112 4.48e-24

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 93.00  E-value: 4.48e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628    28 PLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRACWRLAfNPQEKIIDIALDAGFQNPESFSRAFRSAFAQS 107
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLR-DTDLSVTEIALRVGFSSQSYFSRAFKKLFGVT 79


                   ....*
gi 497337628   108 PSQFR 112
Cdd:smart00342  80 PSEYR 84
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 13-114 1.23e-23

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 97.92  E-value: 1.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  13 RFQQVCLYIERHLDTPLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRACWRLAfNPQEKIIDIALDAGFQN 92
Cdd:COG4977  211 RLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLE-TTDLSIEEIAAACGFGS 289

                         90       100
                 ....*....|....*....|..
gi 497337628  93 PESFSRAFRSAFAQSPSQFRQQ 114
Cdd:COG4977  290 ASHFRRAFRRRFGVSPSAYRRR 311
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
21-114 8.19e-23

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 94.46  E-value: 8.19e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  21 IERHLDTPLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRACWRLAfNPQEKIIDIALDAGFQNPESFSRAF 100
Cdd:COG2207  161 LLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLA-ETDLSISEIAYELGFSSQSHFSRAF 239

                         90
                 ....*....|....
gi 497337628 101 RSAFAQSPSQFRQQ 114
Cdd:COG2207  240 KKRFGVTPSEYRKR 253
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 15-129 9.12e-20

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 87.80  E-value: 9.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  15 QQVCLYIERHLDTPLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRAcwRLAFNPQEKIIDIALDAGFQNPE 94
Cdd:COG2169   87 ARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRA--RQLLQTGLSVTDAAYAAGFGSLS 164

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 497337628  95 SFSRAFRSAFAQSPSQFRQQPDWLEWHRRVPKHTL 129
Cdd:COG2169  165 RFYEAFKKLLGMTPSAYRRGGAGAAIRFAPTPCSL 199
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
20-147 4.83e-16

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 76.20  E-value: 4.83e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  20 YIERHLDTPLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRAC--WRLAFNPqekIIDIALDAGFQNPESFS 97
Cdd:PRK15121  13 WLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKAAvaLRLTSRP---ILDIALQYRFDSQQTFT 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 497337628  98 RAFRSAFAQSPSQFRQQPDWLEWHRRvPKHTLQEQHPMDVKIIQLPTTQI 147
Cdd:PRK15121  90 RAFKKQFAQTPALYRRSPEWSAFGIR-PPIRLGEFTLPEHEFVTLPETPL 138
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
20-114 1.70e-14

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 68.03  E-value: 1.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  20 YIERHLDTPLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRACWRLAfNPQEKIIDIALDAGFQNPESFSRA 99
Cdd:PRK10219  13 WIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELR-TTERPIFDIAMDLGYVSQQTFSRV 91

                         90
                 ....*....|....*
gi 497337628 100 FRSAFAQSPSQFRQQ 114
Cdd:PRK10219  92 FRRQFDRTPSDYRHR 106
ftrA PRK09393
transcriptional activator FtrA; Provisional
 3-114 2.36e-14

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 71.92  E-value: 2.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628   3 DTQVSPAFAGRFQQVCLYIERHLDTPLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRAcwR-LAFNPQEKI 81
Cdd:PRK09393 209 PRPVASRESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARA--RdLLESSALSI 286

                         90       100       110
                 ....*....|....*....|....*....|...
gi 497337628  82 IDIALDAGFQNPESFSRAFRSAFAQSPSQFRQQ 114
Cdd:PRK09393 287 DQIAERAGFGSEESLRHHFRRRAATSPAAYRKR 319
YdeE COG3708
Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription] ...
 135-289 5.64e-12

Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription];


Pssm-ID: 442922  Cd Length: 157  Bit Score: 62.35  E-value: 5.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628 135 MDVKIIQLPTTQIARLRHRGNpdLVNETAAKFIA--WRKVSGLSP------VASCATWGISWDdpAATPADDFRFDIGGT 206
Cdd:COG3708    1 MEYRIVEKPAFKLVGLSARTS--NSDEEANEEIPalWQRFLPEGLaeipnlSNPGGLYGVCTD--YESDEGEFDYLAGVE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628 207 VSQ--PVPEnsfGVVNGEIPGGRCAVVRHHGSLDTLAQSIW-FLYRDWLPASGESLRDFPVFFRYLTfvHEVGEHELQTD 283
Cdd:COG3708   77 VSSfdEVPE---GLETLEIPAGTYAVFTHKGPMPEALQETWqYIYSEWLPSSGYERADGPDFEVYDE--RDDPSPDSEVE 151


                 ....*.
gi 497337628 284 VYLPLK 289
Cdd:COG3708  152 IWIPIK 157
BltR2 COG4978
GyrI-like small molecule binding domain [Signal transduction mechanisms];
137-284 1.03e-11

GyrI-like small molecule binding domain [Signal transduction mechanisms];


Pssm-ID: 444003  Cd Length: 144  Bit Score: 61.56  E-value: 1.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628 137 VKIIQLPTTQIARLRHRGN----PDLVNETAAKFIAWRKVSGLSPVASCatwGISWDDpaaTPADDFRFDIGGTVSQPVP 212
Cdd:COG4978    1 VEVKELPAQPVASIRATVPmdelGELIGEAFGELFAYLAENGIEPAGPP---FAIYHD---TDEDDVDVEVGVPVAGPLP 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497337628 213 ENSfGVVNGEIPGGRCAVVRHHGSLDTLAQSiWFLYRDWLPASGESLRDfPVFFRYLT-FVHEVGEHELQTDV 284
Cdd:COG4978   75 GTG-DIKVGTLPAGKAATATHRGPYDTLDEA-YEALLAWIEENGLEVAG-PPREVYLTdPGNEPDPEEWVTEI 144
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
13-113 2.49e-11

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 63.27  E-value: 2.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  13 RFQQVCLYIERhlDTPLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRAcwRLAFNPQEKIIDIALDAGFQN 92
Cdd:PRK15435  86 KITHACRLLEQ--ETPVTLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRL--REALAKGESVTTSILNAGFPD 161

                         90       100
                 ....*....|....*....|.
gi 497337628  93 PESFSRAFRSAFAQSPSQFRQ 113
Cdd:PRK15435 162 SSSYYRKADETLGMTAKQFRH 182
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 6-114 6.26e-11

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 61.59  E-value: 6.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628   6 VSPAFAGRFQQVCLYIERHLDTP-LSLETLSAIAHSSPYHFHRQFsAYSGVPLYRYIQWLRLRRACWRL-AFNPQEKIID 83
Cdd:PRK09685 191 VQPRRERQFQKVVALIDQSIQEEiLRPEWIAGELGISVRSLYRLF-AEQGLVVAQYIRNRRLDRCADDLrPAADDEKITS 269

                         90       100       110
                 ....*....|....*....|....*....|.
gi 497337628  84 IALDAGFQNPESFSRAFRSAFAQSPSQFRQQ 114
Cdd:PRK09685 270 IAYKWGFSDSSHFSTAFKQRFGVSPGEYRRK 300
Cass2 pfam14526
Integron-associated effector binding protein; This family contains Cass2 from Vibrio cholerae, ...
 138-288 3.47e-10

Integron-associated effector binding protein; This family contains Cass2 from Vibrio cholerae, an integron-associated protein that has been shown to bind cationic drug compounds with submicromolar affinity. Cass2 has been proposed to be representative of a larger family of independent effector-binding proteins associated with lateral gene transfer within Vibrio and other closely-related species.


Pssm-ID: 434016 [Multi-domain]  Cd Length: 149  Bit Score: 57.37  E-value: 3.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  138 KIIQLPTTQIARLRHRG-NPDLV-NETAAKFiaWRKV--SGLSP--VASCATWGISWDDPaaTPADDFRFDIGGTVSQpV 211
Cdd:pfam14526   1 EIVELPSFTVAGIRYEGpNEYEDhNKEIGKF--WEEFneDGRLPniKKDDKSYGIYVDYE--DEENEFDYYAGVEVPS-F 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497337628  212 PENSFGVVNGEIPGGRCAVVRHHGSLDTLAQSIW-FLYRDWLPASGESLRDFPVFFRYltfvHEVGEHELQTDVYLPL 288
Cdd:pfam14526  76 SELPEGLVVIEIPGGKYAVFTIEGDFPDAIAEAWtRIYGWLLPNSGYERAGGPDFEVY----KENGDENMKIELYIPV 149
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
20-112 1.30e-09

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 55.11  E-value: 1.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  20 YIERHLDTPLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRACWRLAfNPQEKIIDIALDAGFQNPESFSRA 99
Cdd:PRK11511  17 WIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLK-ESNEPILYLAERYGFESQQTLTRT 95

                         90
                 ....*....|...
gi 497337628 100 FRSAFAQSPSQFR 112
Cdd:PRK11511  96 FKNYFDVPPHKYR 108
PRK10016 PRK10016
DNA gyrase inhibitor SbmC;
135-289 2.67e-09

DNA gyrase inhibitor SbmC;


Pssm-ID: 182195  Cd Length: 156  Bit Score: 55.06  E-value: 2.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628 135 MDVKIIQLPTTQIARLRHRGN-PDLVNETAAKFIAWRKVSGLSPVAscatW-GISWDDPAATPADDFRFDIGGTVSQP-- 210
Cdd:PRK10016   1 MNYEIKQEQKRTIAGFHLVGPwEQTVKQGFEQLMMWVDSHNIVPKE----WvAVYYDNPDEVPAEKLRCDTVVTVPDDfv 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497337628 211 VPENSFGVVNGEIPGGRCAVVRHHGSLDTLAQSIWFLYRDWLPASGESLRDFPVFFRYLTFVHEVGEHELqtDVYLPLK 289
Cdd:PRK10016  77 LPENSEGVILTEIPGGQYAVAVARVVDDDFAKPWYQFFNSLLQDSAYQMAPKPCFEVYLNDGAEDGYWDI--EMYVPVQ 153
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
11-116 8.73e-09

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 55.07  E-value: 8.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  11 AGRFQQVCLYIERHLDTPLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRACWRLAFNpQEKIIDIALDAGF 90
Cdd:PRK13503 170 DARLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHS-DASVTDIAYRCGF 248

                         90       100
                 ....*....|....*....|....*.
gi 497337628  91 QNPESFSRAFRSAFAQSPSQFRQQPD 116
Cdd:PRK13503 249 GDSNHFSTLFRREFSWSPRDIRQGRD 274
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
6-114 1.64e-07

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 51.51  E-value: 1.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628   6 VSPAFAGRFQQVCLYIERHLDTPLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRACWRLAFNpQEKIIDIA 85
Cdd:PRK10572 177 LHPPMDPRVREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTT-RMPIATIG 255

                         90       100
                 ....*....|....*....|....*....
gi 497337628  86 LDAGFQNPESFSRAFRSAFAQSPSQFRQQ 114
Cdd:PRK10572 256 RNVGYDDQLYFSRVFKKCTGASPSEFRAR 284
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 80-113 7.62e-05

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 39.44  E-value: 7.62e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 497337628   80 KIIDIALDAGFqNPESFSRAFRSAFAQSPSQFRQ 113
Cdd:pfam00165  10 TIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
BltR2 COG4978
GyrI-like small molecule binding domain [Signal transduction mechanisms];
136-203 3.78e-04

GyrI-like small molecule binding domain [Signal transduction mechanisms];


Pssm-ID: 444003  Cd Length: 144  Bit Score: 39.98  E-value: 3.78e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497337628 136 DVKIIQLPTTQIARLRHRGNPDLVNETAAKFIAWRKVSGLSPVASCatWGISWDDPAATPA-DDFRFDI 203
Cdd:COG4978   78 DIKVGTLPAGKAATATHRGPYDTLDEAYEALLAWIEENGLEVAGPP--REVYLTDPGNEPDpEEWVTEI 144
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
25-113 4.91e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 40.81  E-value: 4.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  25 LDTPLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRACWRLAFNPQeKIIDIALDAGFQNPESFSRAFRSAF 104
Cdd:PRK13502 189 LECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPL-MISEISMQCGFEDSNYFSVVFTRET 267


                 ....*....
gi 497337628 105 AQSPSQFRQ 113
Cdd:PRK13502 268 GMTPSQWRH 276
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 21-62 1.26e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 35.98  E-value: 1.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 497337628   21 IERHLDTPLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQ 62
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
25-113 2.67e-03

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 38.93  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497337628  25 LDTPLSLETLSAIAHSSPYHFHRQFSAYSGVPLYRYIQWLRLRRACWRLAfNPQEKIIDIALDAGFQNPESFSRAFRSAF 104
Cdd:PRK13500 219 LKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQ-HSRLLISDISTECGFEDSNYFSVVFTRET 297


                 ....*....
gi 497337628 105 AQSPSQFRQ 113
Cdd:PRK13500 298 GMTPSQWRH 306
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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