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Conserved domains on  [gi|497797191|ref|WP_010111375|]
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helix-turn-helix transcriptional regulator [Burkholderia oklahomensis]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 12204063)

helix-turn-helix (HTH) transcriptional regulator containing an AraC family DNA-binding HTH domain controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.1310
Gene Ontology:  GO:0006355|GO:0043565|GO:0003700
PubMed:  2644244|15808743|8831795
SCOP:  4000332

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
234-316 2.45e-21

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 86.07  E-value: 2.45e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191   234 PTIAMLAKETGLSVLKLKRGFRQLFDHSVYGLFQQERMHEARRRLSSADMPVMTVAADMGYANASHFTAAFQKQFGVNPS 313
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 497797191   314 AFK 316
Cdd:smart00342  82 EYR 84
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
234-316 2.45e-21

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 86.07  E-value: 2.45e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191   234 PTIAMLAKETGLSVLKLKRGFRQLFDHSVYGLFQQERMHEARRRLSSADMPVMTVAADMGYANASHFTAAFQKQFGVNPS 313
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 497797191   314 AFK 316
Cdd:smart00342  82 EYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
166-319 7.25e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 87.14  E-value: 7.25e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191 166 HALQDRHRYAHGRAGRPSMWLLGQSLALASLVIEAHGDAAPHAWPLPAAERQKLLRARDLLLADLSRAPTIAMLAKETGL 245
Cdd:COG2207  101 LLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGL 180

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497797191 246 SVLKLKRGFRQLFDHSVYGLFQQERMHEARRRLSSADMPVMTVAADMGYANASHFTAAFQKQFGVNPSAFKQRR 319
Cdd:COG2207  181 SPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRL 254
HTH_18 pfam12833
Helix-turn-helix domain;
239-318 5.25e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 79.94  E-value: 5.25e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191  239 LAKETGLSVLKLKRGFRQLFDHSVYGLFQQERMHEARRRL-SSADMPVMTVAADMGYANASHFTAAFQKQFGVNPSAFKQ 317
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 497797191  318 R 318
Cdd:pfam12833  81 R 81
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
235-318 7.23e-09

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 52.62  E-value: 7.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191 235 TIAMLAKETGLSVLKLKRGFRQLFDHSVYGLFQQERMHEARRRLSSADMPVMTVAADMGYANASHFTAAFQKQFGVNPSA 314
Cdd:PRK10219  23 NIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSD 102


                 ....
gi 497797191 315 FKQR 318
Cdd:PRK10219 103 YRHR 106
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
234-316 2.45e-21

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 86.07  E-value: 2.45e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191   234 PTIAMLAKETGLSVLKLKRGFRQLFDHSVYGLFQQERMHEARRRLSSADMPVMTVAADMGYANASHFTAAFQKQFGVNPS 313
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 497797191   314 AFK 316
Cdd:smart00342  82 EYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
166-319 7.25e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 87.14  E-value: 7.25e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191 166 HALQDRHRYAHGRAGRPSMWLLGQSLALASLVIEAHGDAAPHAWPLPAAERQKLLRARDLLLADLSRAPTIAMLAKETGL 245
Cdd:COG2207  101 LLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGL 180

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497797191 246 SVLKLKRGFRQLFDHSVYGLFQQERMHEARRRLSSADMPVMTVAADMGYANASHFTAAFQKQFGVNPSAFKQRR 319
Cdd:COG2207  181 SPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRL 254
HTH_18 pfam12833
Helix-turn-helix domain;
239-318 5.25e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 79.94  E-value: 5.25e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191  239 LAKETGLSVLKLKRGFRQLFDHSVYGLFQQERMHEARRRL-SSADMPVMTVAADMGYANASHFTAAFQKQFGVNPSAFKQ 317
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 497797191  318 R 318
Cdd:pfam12833  81 R 81
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 235-319 2.08e-12

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 66.72  E-value: 2.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191 235 TIAMLAKETGLSVLKLKRGFRQLFDHSVYGLFQQERMHEARRRLSSADMPVMTVAADMGYANASHFTAAFQKQFGVNPSA 314
Cdd:COG4977  228 SVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSA 307


                 ....*
gi 497797191 315 FKQRR 319
Cdd:COG4977  308 YRRRF 312
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
235-318 7.23e-09

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 52.62  E-value: 7.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191 235 TIAMLAKETGLSVLKLKRGFRQLFDHSVYGLFQQERMHEARRRLSSADMPVMTVAADMGYANASHFTAAFQKQFGVNPSA 314
Cdd:PRK10219  23 NIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSD 102


                 ....
gi 497797191 315 FKQR 318
Cdd:PRK10219 103 YRHR 106
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
191-318 1.41e-08

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 54.91  E-value: 1.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191 191 LALAsLVIEAHGDAAPHAWPLPAAErqKLLRARDLLLADLSRAPTIAMLAKETGLSVLKLKRGFRQLFDHSVYGLFQQER 270
Cdd:PRK13501 153 LQLA-IVLKRHRYRAEQAHLLPDGE--QLDLIMSALQQSLGAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIR 229

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 497797191 271 MHEARRRLSSADMPVMTVAADMGYANASHFTAAFQKQFGVNPSAFKQR 318
Cdd:PRK13501 230 LCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQR 277
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 232-319 4.18e-08

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 53.90  E-value: 4.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191 232 RAPTIAMLAKETGLSVLKLKRGFRQLFDHSVYGLFQQERMHEARRRLSSaDMPVMTVAADMGYANASHFTAAFQKQFGVN 311
Cdd:COG2169   99 DRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQT-GLSVTDAAYAAGFGSLSRFYEAFKKLLGMT 177


                 ....*...
gi 497797191 312 PSAFKQRR 319
Cdd:COG2169  178 PSAYRRGG 185
ftrA PRK09393
transcriptional activator FtrA; Provisional
 196-318 4.93e-07

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 50.35  E-value: 4.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191 196 LVIEAH---GDAAPHAWPLPAAERQKLLRARDLLLADLSRAPTIAMLAKETGLSVLKLKRGFRQLFDHSVYGLFQQERMH 272
Cdd:PRK09393 194 LVVPPHrdgGQAQFVPRPVASRESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLA 273

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 497797191 273 EARRRLSSADMPVMTVAADMGYANASHFTAAFQKQFGVNPSAFKQR 318
Cdd:PRK09393 274 RARDLLESSALSIDQIAERAGFGSEESLRHHFRRRAATSPAAYRKR 319
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
235-319 8.53e-07

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 49.59  E-value: 8.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191 235 TIAMLAKETGLSVLKLKRGFRQLFDHSVYGLFQQERMHEARRRLSSADMPVMTVAADMGYANASHFTAAFQKQFGVNPSA 314
Cdd:PRK10572 201 DIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSE 280


                 ....*
gi 497797191 315 FKQRR 319
Cdd:PRK10572 281 FRARC 285
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 237-318 5.01e-06

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 47.33  E-value: 5.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191 237 AMLAKETGLSVLKLKRGFRQLFDhSVYGLFQQERMHEARRRLSSA--DMPVMTVAADMGYANASHFTAAFQKQFGVNPSA 314
Cdd:PRK09685 218 EWIAGELGISVRSLYRLFAEQGL-VVAQYIRNRRLDRCADDLRPAadDEKITSIAYKWGFSDSSHFSTAFKQRFGVSPGE 296


                 ....
gi 497797191 315 FKQR 318
Cdd:PRK09685 297 YRRK 300
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 231-315 1.37e-05

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 45.83  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191 231 SRAPTIAMLAKETGLSVLKLKRGFRQlfDHSVYG-LFQQERMHEARRRLSSADMPVMTVAADMGYANASHFTAAFQKQFG 309
Cdd:PRK15186 195 SRKWALKDISDSLYMSCSTLKRKLKQ--ENTSFSeVYLNARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKHFK 272


                 ....*.
gi 497797191 310 VNPSAF 315
Cdd:PRK15186 273 TTPSEF 278
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
248-319 2.05e-05

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 45.44  E-value: 2.05e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 497797191 248 LKLKRGFRQLFDHSvyGLFQQE-----RMHEARRRLSSADMPVMTVAADMGYANASHFTAAFQKQFGVNPSAFKQRR 319
Cdd:PRK13503 199 LSLRTLHRQLKQQT--GLTPQRylnrlRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPRDIRQGR 273
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 235-319 2.97e-05

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 44.92  E-value: 2.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191 235 TIAMLAKETGLSVLKLKRGFRQlfDHSVYG-LFQQERMHEARRRLSSADMPVMTVAADMGYANASHFTAAFQKQFGVNPS 313
Cdd:PRK09978 160 TLARIASELLMSPSLLKKKLRE--EETSYSqLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPT 237


                 ....*.
gi 497797191 314 AFKQRR 319
Cdd:PRK09978 238 EYQERS 243
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 265-315 1.58e-04

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 42.67  E-value: 1.58e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 497797191 265 LFQQERMHEARRRLSSADMPVMTVAADMGYANASHFTAAFQKQFGVNPSAF 315
Cdd:PRK15185 253 IYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTF 303
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
235-316 4.05e-04

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 39.70  E-value: 4.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497797191 235 TIAMLAKETGLSVLKLKRGFRQLFDHSVYGLFQQERMHEARRRLSSADMPVMTVAADMGYANASHFTAAFQKQFGVNPSA 314
Cdd:PRK11511  27 SLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTRTFKNYFDVPPHK 106


                 ..
gi 497797191 315 FK 316
Cdd:PRK11511 107 YR 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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