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Conserved domains on  [gi|499173385|ref|WP_010870972|]
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50S ribosomal protein L11 methyltransferase [Methanocaldococcus jannaschii]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 1905023)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
1-151 1.51e-54

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 175.61  E-value: 1.51e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499173385   1 MKLRLKVPQWHYSLLTDYERLAIFKNAIERVVDEDDVVFDLGTGSGILAMIAAKKA-KKVYAIELDPFTYDYAKENIKVN 79
Cdd:COG4076    2 YLMQFFVPRWHHPMLNDVERNDAFKAAIERVVKPGDVVLDIGTGSGLLSMLAARAGaKKVYAVEVNPDIAAVARRIIAAN 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499173385  80 GFN-NIEIIEGDASTYNFKEKADVVIAELLDTALIIEPQVKVMNSIIERgFLKEDVKIIPAKAISTIQLVEAK 151
Cdd:COG4076   82 GLSdRITVINADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKR-LLKPGGRIIPERITNAAQPVESP 153
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
1-151 1.51e-54

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 175.61  E-value: 1.51e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499173385   1 MKLRLKVPQWHYSLLTDYERLAIFKNAIERVVDEDDVVFDLGTGSGILAMIAAKKA-KKVYAIELDPFTYDYAKENIKVN 79
Cdd:COG4076    2 YLMQFFVPRWHHPMLNDVERNDAFKAAIERVVKPGDVVLDIGTGSGLLSMLAARAGaKKVYAVEVNPDIAAVARRIIAAN 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499173385  80 GFN-NIEIIEGDASTYNFKEKADVVIAELLDTALIIEPQVKVMNSIIERgFLKEDVKIIPAKAISTIQLVEAK 151
Cdd:COG4076   82 GLSdRITVINADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKR-LLKPGGRIIPERITNAAQPVESP 153
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 41-114 5.98e-07

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 49.57  E-value: 5.98e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499173385   41 LGTGSGILAM-IAAKKAKKVYAIELDPFTYDYAKENIKVNGFNniEIIEGDASTYNFKEKADVVIAELLDTALII 114
Cdd:pfam06325 168 VGCGSGILAIaALKLGAKKVVGVDIDPVAVRAAKENAELNGVE--ARLEVYLPGDLPKEKADVVVANILADPLIE 240
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 41-105 1.72e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.50  E-value: 1.72e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499173385  41 LGTGSGILAM-IAAKKAKKVYAIELDPFTYDYAKENIKVNGFNNIEIIEGDASTYNFK--EKADVVIA 105
Cdd:cd02440    5 LGCGTGALALaLASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEadESFDVIIS 72
PRK14968 PRK14968
putative methyltransferase; Provisional
 42-104 6.11e-06

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 45.66  E-value: 6.11e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499173385  42 GTGSGILAMIAAKKAKKVYAIELDPFTYDYAKENIKVNGFNN--IEIIEGDASTyNFKEKA-DVVI 104
Cdd:PRK14968  31 GTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNngVEVIRSDLFE-PFRGDKfDVIL 95
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 41-105 4.27e-05

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 43.61  E-value: 4.27e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499173385   41 LGTGSGI--LAMIAAKKAKKVYAIELDPFTYDYAKENIKVNGFNNIEIIEGDASTYNFKEKADVVIA 105
Cdd:TIGR03534  93 LGTGSGAiaLALAKERPDARVTAVDISPEALAVARKNARRLGLENVEFLQGDWFEPLPSGKFDLIVS 159
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
1-151 1.51e-54

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 175.61  E-value: 1.51e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499173385   1 MKLRLKVPQWHYSLLTDYERLAIFKNAIERVVDEDDVVFDLGTGSGILAMIAAKKA-KKVYAIELDPFTYDYAKENIKVN 79
Cdd:COG4076    2 YLMQFFVPRWHHPMLNDVERNDAFKAAIERVVKPGDVVLDIGTGSGLLSMLAARAGaKKVYAVEVNPDIAAVARRIIAAN 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499173385  80 GFN-NIEIIEGDASTYNFKEKADVVIAELLDTALIIEPQVKVMNSIIERgFLKEDVKIIPAKAISTIQLVEAK 151
Cdd:COG4076   82 GLSdRITVINADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKR-LLKPGGRIIPERITNAAQPVESP 153
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 41-105 1.19e-09

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 57.08  E-value: 1.19e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499173385  41 LGTGSGILAMI--AAKKAKKVYAIELDPFTYDYAKENIKVNGFNN-IEIIEGDASTYNF---KEKADVVIA 105
Cdd:COG4123   44 LGTGTGVIALMlaQRSPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDLKEFAAelpPGSFDLVVS 114
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
41-105 9.47e-08

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 51.71  E-value: 9.47e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499173385  41 LGTGSGILAMIAAKK-AKKVYAIELDPFTYDYAKENIKVNGF-NNIEIIEGDASTynfKEKADVVIA 105
Cdd:COG2264  155 VGCGSGILAIAAAKLgAKRVLAVDIDPVAVEAARENAELNGVeDRIEVVLGDLLE---DGPYDLVVA 218
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 41-114 5.98e-07

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 49.57  E-value: 5.98e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499173385   41 LGTGSGILAM-IAAKKAKKVYAIELDPFTYDYAKENIKVNGFNniEIIEGDASTYNFKEKADVVIAELLDTALII 114
Cdd:pfam06325 168 VGCGSGILAIaALKLGAKKVVGVDIDPVAVRAAKENAELNGVE--ARLEVYLPGDLPKEKADVVVANILADPLIE 240
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 59-112 8.26e-07

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 49.09  E-value: 8.26e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499173385  59 VYAIELDPFTYDYAKENIKVNGF-NNIEIIEGDAS--TYNFKEKADVVIA-------ELLDTAL 112
Cdd:COG2520  206 VVAIDINPDAVEYLKENIRLNKVeDRVTPILGDARevAPELEGKADRIIMnlphsadEFLDAAL 269
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 41-105 1.72e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.50  E-value: 1.72e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499173385  41 LGTGSGILAM-IAAKKAKKVYAIELDPFTYDYAKENIKVNGFNNIEIIEGDASTYNFK--EKADVVIA 105
Cdd:cd02440    5 LGCGTGALALaLASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEadESFDVIIS 72
PRK14968 PRK14968
putative methyltransferase; Provisional
 42-104 6.11e-06

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 45.66  E-value: 6.11e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499173385  42 GTGSGILAMIAAKKAKKVYAIELDPFTYDYAKENIKVNGFNN--IEIIEGDASTyNFKEKA-DVVI 104
Cdd:PRK14968  31 GTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNngVEVIRSDLFE-PFRGDKfDVIL 95
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 42-106 1.43e-05

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 44.69  E-value: 1.43e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499173385  42 GTGSG----ILAMIaakkAKKVYAIELDPFTYDYAKENIKVNGFNNIEIIEGDAStYNFKEKA--DVVIAE 106
Cdd:COG2518   74 GTGSGyqaaVLARL----AGRVYSVERDPELAERARERLAALGYDNVTVRVGDGA-LGWPEHApfDRIIVT 139
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 41-105 1.52e-05

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 45.15  E-value: 1.52e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499173385  41 LGTGSGI--LAMIAAKKAKKVYAIELDPFTYDYAKENIKVNGFNNIEIIEGDASTYNFKEKADVVIA 105
Cdd:PRK09328 115 LGTGSGAiaLALAKERPDAEVTAVDISPEALAVARRNAKHGLGARVEFLQGDWFEPLPGGRFDLIVS 181
Met_10 pfam02475
Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of ...
 59-111 2.79e-05

Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast suggesting this protein may be involved in methionine biosynthesis, transport and/or utilization.


Pssm-ID: 396850 [Multi-domain]  Cd Length: 198  Bit Score: 43.88  E-value: 2.79e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 499173385   59 VYAIELDPFTYDYAKENIKVNGFNN-IEIIEGDASTYNFKEKADVVIAELLDTA 111
Cdd:pfam02475 126 VYAIELNPESYKYLKENIKLNKVEDvVKPILGDVREVILEDVADRVVMNLPGSA 179
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 41-105 4.27e-05

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 43.61  E-value: 4.27e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499173385   41 LGTGSGI--LAMIAAKKAKKVYAIELDPFTYDYAKENIKVNGFNNIEIIEGDASTYNFKEKADVVIA 105
Cdd:TIGR03534  93 LGTGSGAiaLALAKERPDARVTAVDISPEALAVARKNARRLGLENVEFLQGDWFEPLPSGKFDLIVS 159
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
41-105 6.28e-05

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 43.22  E-value: 6.28e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499173385  41 LGTGSGILAMIAAKK-AKKVYAIELDPFTYDYAKENIKVNG-FNNIEIIEGDastynfkEKADVVIA 105
Cdd:PRK00517 126 VGCGSGILAIAAAKLgAKKVLAVDIDPQAVEAARENAELNGvELNVYLPQGD-------LKADVIVA 185
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
41-104 2.24e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 41.04  E-value: 2.24e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499173385  41 LGTGSGILAMIAAKK-AKKVYAIELDPFTYDYAKENIKvNGFNNIEIIEGDASTYNFKEKADVVI 104
Cdd:COG2263   52 LGCGTGMLAIGAALLgAKKVVGVDIDPEALEIARENAE-RLGVRVDFIRADVTRIPLGGSVDTVV 115
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 41-105 2.32e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 39.47  E-value: 2.32e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499173385   41 LGTGSGILA-MIAAKKAKKVYAIELDPFTYDYAKENIKVNGFnNIEIIEGDASTYNFK-EKADVVIA 105
Cdd:pfam13649   4 LGCGTGRLTlALARRGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDLPFPdGSFDLVVS 69
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
42-107 3.33e-04

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 41.04  E-value: 3.33e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499173385  42 GTGSGILAMIAAKKAKKVYAIELDPFTYDYAKENIKVngFNNIEIIEGDASTYNFKEkADVVIAEL 107
Cdd:PRK14896  37 GPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDEIA--AGNVEIIEGDALKVDLPE-FNKVVSNL 99
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 59-104 5.93e-04

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 40.54  E-value: 5.93e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 499173385  59 VYAIELDPFTYDYAKENIKVNGFNNIEIIEGDA----STYNFKEKADVVI 104
Cdd:COG2265  258 VIGVEIVPEAVEDARENARLNGLKNVEFVAGDLeevlPELLWGGRPDVVV 307
PRMT5 pfam05185
PRMT5 arginine-N-methyltransferase; The human homolog of yeast Skb1 (Shk1 kinase-binding ...
 59-108 7.26e-04

PRMT5 arginine-N-methyltransferase; The human homolog of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase. These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.


Pssm-ID: 428356  Cd Length: 171  Bit Score: 39.11  E-value: 7.26e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 499173385   59 VYAIELDPFTYDYAKENIKVNGFNN-IEIIEGDASTYNFKEKADVVIAELL 108
Cdd:pfam05185  94 IYAVEKNPNAYVTLQKRINFEKWGDkVTIISSDMREWQGPEKADILVSELL 144
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 59-107 1.52e-03

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 38.39  E-value: 1.52e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 499173385  59 VYAIELDPFTYDYAKENIKVNGFNNIEIIEGDASTYNFK-EKADVVIAEL 107
Cdd:COG1041   51 VIGSDIDPKMVEGARENLEHYGYEDADVIRGDARDLPLAdESVDAIVTDP 100
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 41-105 2.27e-03

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 38.59  E-value: 2.27e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499173385  41 LGTGSGI--LAMIAAKKAKKVYAIELDPFTYDYAKENIKVNGFNN-IEIIEGDASTY-NFKEKADVVIA 105
Cdd:COG2890  119 LGTGSGAiaLALAKERPDARVTAVDISPDALAVARRNAERLGLEDrVRFLQGDLFEPlPGDGRFDLIVS 187
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 41-105 3.27e-03

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 36.90  E-value: 3.27e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499173385  41 LGTGSGILAMIAAKKAKKVYAIELDPFTYDYAKENIKVNGFnNIEIIEGDASTYNFKEKA-DVVIA 105
Cdd:COG2226   29 LGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLPFPDGSfDLVIS 93
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 59-91 4.69e-03

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 37.09  E-value: 4.69e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 499173385  59 VYAIELDPFTYDYAKENIKVNGF-NNIEIIEGDA 91
Cdd:COG4122   44 LTTIEIDPERAAIARENFARAGLaDRIRLILGDA 77
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 41-105 6.18e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 35.33  E-value: 6.18e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499173385   41 LGTGSGILAMIAAKKAKKVYAIELDPFTYDYAKENIKVNGFNnieIIEGDASTYNFKEKA-DVVIA 105
Cdd:pfam08241   3 VGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLT---FVVGDAEDLPFPDNSfDLVLS 65
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 41-105 7.86e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 36.43  E-value: 7.86e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499173385  41 LGTGSGILAMI-AAKKAKKVYAIELDPFTYDYAKENIKVNGFNNIEIIEGDASTYNFK--EKADVVIA 105
Cdd:COG0500   33 LGCGTGRNLLAlAARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELDPLpaESFDLVVA 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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