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Conserved domains on  [gi|499189351|ref|WP_010886891|]
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peptide chain release factor N(5)-glutamine methyltransferase [Deinococcus radiodurans]

Protein Classification

N5-glutamine methyltransferase family protein( domain architecture ID 11458394)

N5-glutamine methyltransferase family protein such as peptide chain release factor N(5)-glutamine methyltransferase, which modifies the glutamine residue in the universally conserved glycylglycylglutamine (GGQ) motif of peptide chain release factor, resulting in almost complete loss of release activity

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0003676|GO:0032259|GO:1904047
PubMed:  12826405|12504684|12741815
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 1-276 3.45e-108

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 314.40  E-value: 3.45e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351   1 MQLRDLLTQATARLTRAGVPSPEVDARLLLEHVLGLNRTAFLLRGGEEIGPDAEARAWDSIERRAARVPLQHLTGEVEWG 80
Cdd:COG2890    1 MTIRELLRWAAARLAAAGVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRAAGEPLAYILGEAEFY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  81 GVRLTSDARALVPRPETEWLLHLALEELRRVEKPRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSG 160
Cdd:COG2890   81 GLEFKVDPGVLIPRPETEELVELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 161 LD--VKFVEGSLLAGLS--GPFNLIVSNPPYLPTADRATADPEVR-HDPDLALYAGEDGLDVARPLVAEAAAALVPGGAL 235
Cdd:COG2890  161 LEdrVRFLQGDLFEPLPgdGRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRLLKPGGWL 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 499189351 236 LLELDPRNAPTLAAELRTAGW-QAEVRPDLTGRERFVRARRA 276
Cdd:COG2890  241 LLEIGEDQGEAVRALLEAAGFaDVETHKDLAGRDRVVVARRP 282
 
Name Accession Description Interval E-value
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 1-276 3.45e-108

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 314.40  E-value: 3.45e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351   1 MQLRDLLTQATARLTRAGVPSPEVDARLLLEHVLGLNRTAFLLRGGEEIGPDAEARAWDSIERRAARVPLQHLTGEVEWG 80
Cdd:COG2890    1 MTIRELLRWAAARLAAAGVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRAAGEPLAYILGEAEFY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  81 GVRLTSDARALVPRPETEWLLHLALEELRRVEKPRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSG 160
Cdd:COG2890   81 GLEFKVDPGVLIPRPETEELVELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 161 LD--VKFVEGSLLAGLS--GPFNLIVSNPPYLPTADRATADPEVR-HDPDLALYAGEDGLDVARPLVAEAAAALVPGGAL 235
Cdd:COG2890  161 LEdrVRFLQGDLFEPLPgdGRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRLLKPGGWL 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 499189351 236 LLELDPRNAPTLAAELRTAGW-QAEVRPDLTGRERFVRARRA 276
Cdd:COG2890  241 LLEIGEDQGEAVRALLEAAGFaDVETHKDLAGRDRVVVARRP 282
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 1-275 6.27e-102

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 298.61  E-value: 6.27e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351   1 MQLRDLLTQATARLTRagvpsPEVDARLLLEHVLGLNRTAFLLRGGEEIGPDAEARAWDSIERRAARVPLQHLTGEVEWG 80
Cdd:PRK09328   2 MTIAEALREATARLAS-----PRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFW 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  81 GVRLTSDARALVPRPETEWLLHLALEELRRVEKPRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSG 160
Cdd:PRK09328  77 GLDFKVSPGVLIPRPETEELVEWALEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 161 LD-VKFVEGSLLAGLS-GPFNLIVSNPPYLPTADRATADPEVR-HDPDLALYAGEDGLDVARPLVAEAAAALVPGGALLL 237
Cdd:PRK09328 157 GArVEFLQGDWFEPLPgGRFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWLLL 236

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 499189351 238 ELDPRNAPTLAAELRTAGW-QAEVRPDLTGRERFVRARR 275
Cdd:PRK09328 237 EIGYDQGEAVRALLAAAGFaDVETRKDLAGRDRVVLGRR 275
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 25-271 1.78e-91

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 270.88  E-value: 1.78e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351   25 DARLLLEHVLGLNRTAFLLRGGEEIGPDAEARAWDSIERRAARVPLQHLTGEVEWGGVRLTSDARALVPRPETEWLLHLA 104
Cdd:TIGR03534   1 DAELLLAHVLGKDRAQLLLHPEDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  105 LEELRRveKPRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSGLD-VKFVEGSLLAGL-SGPFNLIV 182
Cdd:TIGR03534  81 LERLKK--GPRVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGLEnVEFLQGDWFEPLpSGKFDLIV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  183 SNPPYLPTADRATADPEVR-HDPDLALYAGEDGLDVARPLVAEAAAALVPGGALLLELDPRNAPTLAAELRTAGW-QAEV 260
Cdd:TIGR03534 159 SNPPYIPEADIHLLDPEVRdFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAAGFaDVET 238

                         250
                  ....*....|.
gi 499189351  261 RPDLTGRERFV 271
Cdd:TIGR03534 239 RKDLAGKDRVV 249
PrmC_N pfam17827
PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the ...
 5-75 1.08e-21

PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors.


Pssm-ID: 436073 [Multi-domain]  Cd Length: 71  Bit Score: 86.00  E-value: 1.08e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499189351    5 DLLTQATARLTRAGVPSPEVDARLLLEHVLGLNRTAFLLRGGEEIGPDAEARAWDSIERRAARVPLQHLTG 75
Cdd:pfam17827   1 EALRWASSRLKEAGIESPRLDAELLLAHVLGLDRTDLLLHPEEELSEEELERFEELLERRAAGEPLQYILG 71
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 115-193 3.48e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 58.98  E-value: 3.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 115 RVLDVGTGTGALALGLkAAIPQAEVTATDLSPEALSLARENAALSGLD-VKFVEGSLLAGLS---GPFNLIVSNPPYLPT 190
Cdd:cd02440    1 RVLDLGCGTGALALAL-ASGPGARVTGVDISPVALELARKAAAALLADnVEVLKGDAEELPPeadESFDVIISDPPLHHL 79


                 ...
gi 499189351 191 ADR 193
Cdd:cd02440   80 VED 82
 
Name Accession Description Interval E-value
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 1-276 3.45e-108

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 314.40  E-value: 3.45e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351   1 MQLRDLLTQATARLTRAGVPSPEVDARLLLEHVLGLNRTAFLLRGGEEIGPDAEARAWDSIERRAARVPLQHLTGEVEWG 80
Cdd:COG2890    1 MTIRELLRWAAARLAAAGVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRAAGEPLAYILGEAEFY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  81 GVRLTSDARALVPRPETEWLLHLALEELRRVEKPRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSG 160
Cdd:COG2890   81 GLEFKVDPGVLIPRPETEELVELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 161 LD--VKFVEGSLLAGLS--GPFNLIVSNPPYLPTADRATADPEVR-HDPDLALYAGEDGLDVARPLVAEAAAALVPGGAL 235
Cdd:COG2890  161 LEdrVRFLQGDLFEPLPgdGRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRLLKPGGWL 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 499189351 236 LLELDPRNAPTLAAELRTAGW-QAEVRPDLTGRERFVRARRA 276
Cdd:COG2890  241 LLEIGEDQGEAVRALLEAAGFaDVETHKDLAGRDRVVVARRP 282
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 1-275 6.27e-102

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 298.61  E-value: 6.27e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351   1 MQLRDLLTQATARLTRagvpsPEVDARLLLEHVLGLNRTAFLLRGGEEIGPDAEARAWDSIERRAARVPLQHLTGEVEWG 80
Cdd:PRK09328   2 MTIAEALREATARLAS-----PRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFW 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  81 GVRLTSDARALVPRPETEWLLHLALEELRRVEKPRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSG 160
Cdd:PRK09328  77 GLDFKVSPGVLIPRPETEELVEWALEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 161 LD-VKFVEGSLLAGLS-GPFNLIVSNPPYLPTADRATADPEVR-HDPDLALYAGEDGLDVARPLVAEAAAALVPGGALLL 237
Cdd:PRK09328 157 GArVEFLQGDWFEPLPgGRFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWLLL 236

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 499189351 238 ELDPRNAPTLAAELRTAGW-QAEVRPDLTGRERFVRARR 275
Cdd:PRK09328 237 EIGYDQGEAVRALLAAAGFaDVETRKDLAGRDRVVLGRR 275
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 25-271 1.78e-91

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 270.88  E-value: 1.78e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351   25 DARLLLEHVLGLNRTAFLLRGGEEIGPDAEARAWDSIERRAARVPLQHLTGEVEWGGVRLTSDARALVPRPETEWLLHLA 104
Cdd:TIGR03534   1 DAELLLAHVLGKDRAQLLLHPEDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  105 LEELRRveKPRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSGLD-VKFVEGSLLAGL-SGPFNLIV 182
Cdd:TIGR03534  81 LERLKK--GPRVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGLEnVEFLQGDWFEPLpSGKFDLIV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  183 SNPPYLPTADRATADPEVR-HDPDLALYAGEDGLDVARPLVAEAAAALVPGGALLLELDPRNAPTLAAELRTAGW-QAEV 260
Cdd:TIGR03534 159 SNPPYIPEADIHLLDPEVRdFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAAGFaDVET 238

                         250
                  ....*....|.
gi 499189351  261 RPDLTGRERFV 271
Cdd:TIGR03534 239 RKDLAGKDRVV 249
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 1-276 3.00e-59

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 189.87  E-value: 3.00e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351    1 MQLRDLLTQATARLTRAGV-PSPEVDARLLLEHVLGLNRTAFLLRGGEEIGPDAEARAWDSIERRAARVPLQHLTGEVEW 79
Cdd:TIGR00536   1 MTIQEFLRWASSALSRAIArENPWLEALLLLEHDLGRERDLLLAFLTEELTPDEKERIFRLVLRRVKGVPVAYLLGSKEF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351   80 GGVRLTSDARALVPRPETEWLLHLALEELrrVEKP---RVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENA 156
Cdd:TIGR00536  81 YGLEFFVNEHVLIPRPETEELVEKALASL--ISQPpilHILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAEENA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  157 ALSGL--DVKFVEGSLLAGLSGP-FNLIVSNPPYLPTADRATADPEVRHDPDLALYAGEDGLDVARPLVAEAAAALVPGG 233
Cdd:TIGR00536 159 EKNQLehRVEFIQSNLFEPLAGQkIDIIVSNPPYIDEEDLADLPNVVRFEPLLALVGGDDGLNILRQIIELAPDYLKPNG 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 499189351  234 ALLLELDPRNAPTLAAELRT--AGWQAEVRPDLTGRERFVRARRA 276
Cdd:TIGR00536 239 FLVCEIGNWQQKSLKELLRIkfTWYDVENGRDLNGKERVVLGFYH 283
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 3-238 6.66e-41

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 142.65  E-value: 6.66e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351    3 LRDLLTQATARLTRAGV------PSPEVDARLLLEHVLGL--NRTAFLLrgGEEIGPDAEARAWDSIERRAA-RVPLQHL 73
Cdd:TIGR03533   4 IRDFLRWAVSRFNAAGLffghgtDNAWDEAVYLVLHALHLplDILEPFL--DARLTPSEKERILELIERRIEeRIPVAYL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351   74 TGEVEWGGVRLTSDARALVPRPETEWLLHLALEELRRVEKP-RVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLA 152
Cdd:TIGR03533  82 TNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPWLEPEPVkRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAVA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  153 RENAALSGLD--VKFVEGSLLAGLSG-PFNLIVSNPPYLPTADRATADPEVRHDPDLALYAGEDGLDVARPLVAEAAAAL 229
Cdd:TIGR03533 162 EINIERHGLEdrVTLIQSDLFAALPGrKYDLIVSNPPYVDAEDMADLPAEYHHEPELALASGEDGLDLVRRILAEAADHL 241


                  ....*....
gi 499189351  230 VPGGALLLE 238
Cdd:TIGR03533 242 NENGVLVVE 250
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 22-269 1.87e-36

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 134.05  E-value: 1.87e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  22 PEVDARLLLEHVLGLNRTAFLLRGGEEIGPDAEARAWDSIERRAARVPLQHLTGEVEWGGVRLTSDARALVPRPETEWLL 101
Cdd:PRK14966 163 PKNEARMLLQYASEYTRVQLLTRGGEEMPDEVRQRADRLAQRRLNGEPVAYILGVREFYGRRFAVNPNVLIPRPETEHLV 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 102 HLALEELRrvEKPRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSGLDVKFVEGSLL---AGLSGPF 178
Cdd:PRK14966 243 EAVLARLP--ENGRVWDLGTGSGAVAVTVALERPDAFVRASDISPPALETARKNAADLGARVEFAHGSWFdtdMPSEGKW 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 179 NLIVSNPPYLPTADRATADPEVRHDPDLALYAGEDGLDVARPLVAEAAAALVPGGALLLELDPRNAPTLAAELRTAGWQA 258
Cdd:PRK14966 321 DIIVSNPPYIENGDKHLLQGDLRFEPQIALTDFSDGLSCIRTLAQGAPDRLAEGGFLLLEHGFDQGAAVRGVLAENGFSG 400

                        250
                 ....*....|..
gi 499189351 259 -EVRPDLTGRER 269
Cdd:PRK14966 401 vETLPDLAGLDR 412
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 1-277 3.41e-29

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 115.35  E-value: 3.41e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351   1 MQ--LRDLLTQATARLTRAGVPSPEVDARLLLEHVLGlNRTAFLLRGGEEIGPDAEARAWDSI-ERRAARVPLQHLTGEV 77
Cdd:PRK01544   1 MQysIKQILSDATDKLNKIGISSPQLEARILLQHVIN-KPIEYLLINLDEQLNEAEIEAFEKLlERRLKHEPIAYITGVK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  78 EWGGVRLTSDARALVPRPETEWLLHL------------------------ALEELRRVEKPRVLDVGTGTGALALGLKAA 133
Cdd:PRK01544  80 EFYSREFIVNKHVLIPRSDTEVLVDVvfqchsresgnpekkqlnpcfrgnDISSNCNDKFLNILELGTGSGCIAISLLCE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 134 IPQAEVTATDLSPEALSLARENAALSGLD--VKFVEGSLLAGLSG-PFNLIVSNPPYLPTADRATADPE-VRHDPDLALY 209
Cdd:PRK01544 160 LPNANVIATDISLDAIEVAKSNAIKYEVTdrIQIIHSNWFENIEKqKFDFIVSNPPYISHSEKSEMAIEtINYEPSIALF 239

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499189351 210 AGEDGLDVARPLVAEAAAALVPGGALLLELDPRNAPTLAAELRTAGWQAE-VRPDLTGRERFVR----------ARRAG 277
Cdd:PRK01544 240 AEEDGLQAYFIIAENAKQFLKPNGKIILEIGFKQEEAVTQIFLDHGYNIEsVYKDLQGHSRVILispinlnrsyARRIG 318
PRK14968 PRK14968
putative methyltransferase; Provisional
 102-237 4.13e-24

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 95.74  E-value: 4.13e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 102 HLALEELRRVEKPRVLDVGTGTGALALGLKAAipQAEVTATDLSPEALSLARENAALSGL---DVKFVEGSLLAGLSG-P 177
Cdd:PRK14968  13 FLLAENAVDKKGDRVLEVGTGSGIVAIVAAKN--GKKVVGVDINPYAVECAKCNAKLNNIrnnGVEVIRSDLFEPFRGdK 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 178 FNLIVSNPPYLPTADrataDPEVRHDPDLALYAGEDGLDVARPLVAEAAAALVPGGALLL 237
Cdd:PRK14968  91 FDVILFNPPYLPTEE----EEEWDDWLNYALSGGKDGREVIDRFLDEVGRYLKPGGRILL 146
PRK14967 PRK14967
putative methyltransferase; Provisional
 92-260 7.57e-23

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 93.58  E-value: 7.57e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  92 VPRPETE-WLLHLALEELRRVEKPRVLDVGTGTGALALGlKAAIPQAEVTATDLSPEALSLARENAALSGLDVKFVEGSL 170
Cdd:PRK14967  15 VYRPQEDtQLLADALAAEGLGPGRRVLDLCTGSGALAVA-AAAAGAGSVTAVDISRRAVRSARLNALLAGVDVDVRRGDW 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 171 LAGLSG-PFNLIVSNPPYLPTADRATADpevrHDPDLALYAGEDGLDVARPLVAEAAAALVPGGALLLELDPRNAP--TL 247
Cdd:PRK14967  94 ARAVEFrPFDVVVSNPPYVPAPPDAPPS----RGPARAWDAGPDGRAVLDRLCDAAPALLAPGGSLLLVQSELSGVerTL 169

                        170
                 ....*....|...
gi 499189351 248 AAeLRTAGWQAEV 260
Cdd:PRK14967 170 TR-LSEAGLDAEV 181
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 103-270 8.10e-22

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 89.53  E-value: 8.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  103 LALEELRRVEKPRVLDVGTGTGALALGLKAAipQAEVTATDLSPEALSLARENAALSGLDVKFVEGSLLAGLSGPFNLIV 182
Cdd:TIGR00537  10 LLEANLRELKPDDVLEIGAGTGLVAIRLKGK--GKCILTTDINPFAVKELRENAKLNNVGLDVVMTDLFKGVRGKFDVIL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  183 SNPPYLPTADRATADPEVrhdpDLALYAGEDGLDVARPLVAEAAAALVPGG-ALLLELDPRNAPTLAAELRTAGWQAEVr 261
Cdd:TIGR00537  88 FNPPYLPLEDDLRRGDWL----DVAIDGGKDGRKVIDRFLDELPEILKEGGrVQLIQSSLNGEPDTFDKLDERGFRYEI- 162


                  ....*....
gi 499189351  262 pdlTGRERF 270
Cdd:TIGR00537 163 ---VAERGL 168
PrmC_N pfam17827
PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the ...
 5-75 1.08e-21

PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors.


Pssm-ID: 436073 [Multi-domain]  Cd Length: 71  Bit Score: 86.00  E-value: 1.08e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499189351    5 DLLTQATARLTRAGVPSPEVDARLLLEHVLGLNRTAFLLRGGEEIGPDAEARAWDSIERRAARVPLQHLTG 75
Cdd:pfam17827   1 EALRWASSRLKEAGIESPRLDAELLLAHVLGLDRTDLLLHPEEELSEEELERFEELLERRAAGEPLQYILG 71
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 115-274 1.61e-21

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 90.20  E-value: 1.61e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 115 RVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSGLD--VKFVEGSLLA----GLSGPFNLIVSNPPY- 187
Cdd:COG4123   40 RVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEdrITVIHGDLKEfaaeLPPGSFDLVVSNPPYf 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 188 LPTADRATADPEVRhdpdLALYAGEDGLDVarpLVAEAAAALVPGGALLLELDPRNAPTLAAELRTAGWQAEvrpdltgR 267
Cdd:COG4123  120 KAGSGRKSPDEARA----IARHEDALTLED---LIRAAARLLKPGGRFALIHPAERLAEILAALRKYGLGPK-------R 185


                 ....*..
gi 499189351 268 ERFVRAR 274
Cdd:COG4123  186 LRPVHPR 192
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 105-187 3.51e-18

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 80.23  E-value: 3.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 105 LEELRRVEKPRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSGLD-VKFVEGSLLAGL-SGPFNLIV 182
Cdd:COG2813   42 LEHLPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLEnVEVLWSDGLSGVpDGSFDLIL 121


                 ....*
gi 499189351 183 SNPPY 187
Cdd:COG2813  122 SNPPF 126
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 103-237 1.32e-17

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 78.02  E-value: 1.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  103 LALEELRRVEKPRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSGLD-VKFVEGSLLAGL-SGPFNL 180
Cdd:pfam05175  22 LLLEHLPKDLSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLEnGEVVASDVYSGVeDGKFDL 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 499189351  181 IVSNPPYlptadratadpevrHDPdlalyaGEDGLDVARPLVAEAAAALVPGGALLL 237
Cdd:pfam05175 102 IISNPPF--------------HAG------LATTYNVAQRFIADAKRHLRPGGELWI 138
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 116-196 6.27e-15

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 68.74  E-value: 6.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  116 VLDVGTGTGALALGLkAAIPQAEVTATDLSPEALSLARENAALSGLDVKFVEGSL--LAGLSGPFNLIVSNPP--YLPTA 191
Cdd:pfam13649   1 VLDLGCGTGRLTLAL-ARRGGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAedLPFPDGSFDLVVSSGVlhHLPDP 79


                  ....*
gi 499189351  192 DRATA 196
Cdd:pfam13649  80 DLEAA 84
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 104-257 5.58e-13

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 64.63  E-value: 5.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 104 ALEELRRVEKPRVLDVGTGTGALALGLKAAipQAEVTATDLSPEALSLARENAALSGLDVKFVEGSL--LAGLSGPFNLI 181
Cdd:COG2226   14 LLAALGLRPGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGLNVEFVVGDAedLPFPDGSFDLV 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499189351 182 VSNppYLptadratadpeVRHDPDLALYAGEdgldVARplvaeaaaALVPGGALLL-ELDPRNAPTLAAELRTAGWQ 257
Cdd:COG2226   92 ISS--FV-----------LHHLPDPERALAE----IAR--------VLKPGGRLVVvDFSPPDLAELEELLAEAGFE 143
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
102-184 1.32e-12

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 66.35  E-value: 1.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 102 HLALEELRRVEKP--RVLDVGTGTGALALG---LKAaipqAEVTATDLSPEALSLARENAALSGLD--VKFVEGSLLAGl 174
Cdd:COG2264  136 RLCLEALEKLLKPgkTVLDVGCGSGILAIAaakLGA----KRVLAVDIDPVAVEAARENAELNGVEdrIEVVLGDLLED- 210

                         90
                 ....*....|
gi 499189351 175 sGPFNLIVSN 184
Cdd:COG2264  211 -GPYDLVVAN 219
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
114-184 2.40e-12

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 61.76  E-value: 2.40e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499189351 114 PRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAAlsglDVKFVEGSLLA-GLSGPFNLIVSN 184
Cdd:COG4106    3 RRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLP----NVRFVVADLRDlDPPEPFDLVVSN 70
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
100-186 2.45e-11

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 61.46  E-value: 2.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 100 LLHLALEELRRVEKpRVLDVGTGTGALALGlkAAIPQAE-VTATDLSPEALSLARENAALSGLDVKFVEGSLL-AGLSGP 177
Cdd:COG2263   34 LLHLAYLRGDIEGK-TVLDLGCGTGMLAIG--AALLGAKkVVGVDIDPEALEIARENAERLGVRVDFIRADVTrIPLGGS 110


                 ....*....
gi 499189351 178 FNLIVSNPP 186
Cdd:COG2263  111 VDTVVMNPP 119
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 115-193 3.48e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 58.98  E-value: 3.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 115 RVLDVGTGTGALALGLkAAIPQAEVTATDLSPEALSLARENAALSGLD-VKFVEGSLLAGLS---GPFNLIVSNPPYLPT 190
Cdd:cd02440    1 RVLDLGCGTGALALAL-ASGPGARVTGVDISPVALELARKAAAALLADnVEVLKGDAEELPPeadESFDVIISDPPLHHL 79


                 ...
gi 499189351 191 ADR 193
Cdd:cd02440   80 VED 82
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 93-184 1.44e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 57.72  E-value: 1.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  93 PRPETEWLLHLALEELRRVEKP-RVLDVGTGTGALALGLKAAipQAEVTATDLSPEALSLARENAAlsGLDVKFVEGSL- 170
Cdd:COG2227    4 PDARDFWDRRLAALLARLLPAGgRVLDVGCGTGRLALALARR--GADVTGVDISPEALEIARERAA--ELNVDFVQGDLe 79

                         90
                 ....*....|....*
gi 499189351 171 -LAGLSGPFNLIVSN 184
Cdd:COG2227   80 dLPLEDGSFDLVICS 94
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 98-183 1.88e-10

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 58.02  E-value: 1.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  98 EWLLHLALEELRRVEKPRVLDVGTGTGALALGLkAAIPQAEVTATDLSPEALSLARENAALSGLD--VKFVEGSLLA-GL 174
Cdd:COG2230   37 EAKLDLILRKLGLKPGMRVLDIGCGWGGLALYL-ARRYGVRVTGVTLSPEQLEYARERAAEAGLAdrVEVRLADYRDlPA 115


                 ....*....
gi 499189351 175 SGPFNLIVS 183
Cdd:COG2230  116 DGQFDAIVS 124
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
102-184 5.22e-10

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 58.24  E-value: 5.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 102 HLALEELRRVEKP--RVLDVGTGTGALALG---LKAaipqAEVTATDLSPEALSLARENAALSG--LDVKFVEGSLlagl 174
Cdd:PRK00517 107 RLCLEALEKLVLPgkTVLDVGCGSGILAIAaakLGA----KKVLAVDIDPQAVEAARENAELNGveLNVYLPQGDL---- 178

                         90
                 ....*....|
gi 499189351 175 sgPFNLIVSN 184
Cdd:PRK00517 179 --KADVIVAN 186
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
113-197 1.95e-09

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 57.26  E-value: 1.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 113 KPRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSGLDVKFVEGSLLAGLSGPFNLIVSNPPY---LP 189
Cdd:PRK09489 197 KGKVLDVGCGAGVLSAVLARHSPKIRLTLSDVSAAALESSRATLAANGLEGEVFASNVFSDIKGRFDMIISNPPFhdgIQ 276


                 ....*...
gi 499189351 190 TADRATAD 197
Cdd:PRK09489 277 TSLDAAQT 284
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 103-184 2.18e-09

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 56.89  E-value: 2.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  103 LALEELRRVEKPR--VLDVGTGTGALALG---LKAAipqaEVTATDLSPEALSLARENAALSGLDVKFVEGSLLAGLSGP 177
Cdd:pfam06325 150 LCLEALERLVKPGesVLDVGCGSGILAIAalkLGAK----KVVGVDIDPVAVRAAKENAELNGVEARLEVYLPGDLPKEK 225


                  ....*..
gi 499189351  178 FNLIVSN 184
Cdd:pfam06325 226 ADVVVAN 232
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 115-184 2.63e-09

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 54.73  E-value: 2.63e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499189351  115 RVLDVGTGTGALALGL-KAAIPQAEVTATDLSPEALSLARENAALSGLD-VKFVEGSLLAGLS----GPFNLIVSN 184
Cdd:pfam13847   6 RVLDLGCGTGHLSFELaEELGPNAEVVGIDISEEAIEKARENAQKLGFDnVEFEQGDIEELPElledDKFDVVISN 81
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 115-182 9.73e-09

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 54.12  E-value: 9.73e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499189351 115 RVLDVGTGTG--ALALGLKAAipqAEVTATDLSPEALSLARENAALSGLDVKFVEGSLLAG-LSGPFNLIV 182
Cdd:COG3897   73 RVLELGCGLGlvGIAAAKAGA---ADVTATDYDPEALAALRLNAALNGVAITTRLGDWRDPpAAGGFDLIL 140
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
98-184 1.49e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 53.08  E-value: 1.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  98 EWLLHLALEELRRVEKPRVLDVGTGTGALALGLKAAIpqAEVTATDLSPEALSLARENaalsGLDVKFVEGSL--LAGLS 175
Cdd:COG4976   32 ALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRG--YRLTGVDLSEEMLAKAREK----GVYDRLLVADLadLAEPD 105


                 ....*....
gi 499189351 176 GPFNLIVSN 184
Cdd:COG4976  106 GRFDLIVAA 114
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 117-184 1.91e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 50.83  E-value: 1.91e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499189351  117 LDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSGLD----VKFVEGSLLAGLSGPFNLIVSN 184
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLnavrVELFQLDLGELDPGSFDVVVAS 72
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 105-184 2.78e-08

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 53.44  E-value: 2.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  105 LEELRRVEKPRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENaalSGLDVKFVEGSL--LAGLSGPFNLIV 182
Cdd:TIGR02072  27 LKEKGIFIPASVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAKTK---LSENVQFICGDAekLPLEDSSFDLIV 103


                  ..
gi 499189351  183 SN 184
Cdd:TIGR02072 104 SN 105
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 100-200 3.36e-08

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 53.64  E-value: 3.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 100 LLHLALEELRRVEKPRVLDVGTGTGALALGLkaAIPQAEVTATDLSPEALSLARENAALSGLD-VKFVEGSLLAGLS--- 175
Cdd:COG2265  221 LYAAALEWLDLTGGERVLDLYCGVGTFALPL--ARRAKKVIGVEIVPEAVEDARENARLNGLKnVEFVAGDLEEVLPell 298

                         90       100
                 ....*....|....*....|....*..
gi 499189351 176 --GPFNLIVSNPPylptadRATADPEV 200
Cdd:COG2265  299 wgGRPDVVVLDPP------RAGAGPEV 319
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 100-184 5.05e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 51.84  E-value: 5.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 100 LLHLALEELRRVEKP-RVLDVGTGTGALALGLkAAIPQAEVTATDLSPEALSLARENAALSGLD-VKFVEGSLLAGL--- 174
Cdd:COG0500   13 GLAALLALLERLPKGgRVLDLGCGTGRNLLAL-AARFGGRVIGIDLSPEAIALARARAAKAGLGnVEFLVADLAELDplp 91

                         90
                 ....*....|
gi 499189351 175 SGPFNLIVSN 184
Cdd:COG0500   92 AESFDLVVAF 101
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 115-168 3.74e-07

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 49.77  E-value: 3.74e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 499189351 115 RVLDVGTGTGALALGL-KAAIPQAEVTATDLSPEALSLARENAALSGLD--VKFVEG 168
Cdd:PRK00216  54 KVLDLACGTGDLAIALaKAVGKTGEVVGLDFSEGMLAVGREKLRDLGLSgnVEFVQG 110
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 98-162 2.35e-06

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 46.56  E-value: 2.35e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499189351   98 EWLLHLALEELRRVEK--PRVLDVGTGTGALALGLKAAIPQAEVTATDLsPEALSLARENAALSGLD 162
Cdd:pfam10294  30 KYLEMKIFKELGANNLsgLNVLELGSGTGLVGIAVALLLPGASVTITDL-EEALELLKKNIELNALS 95
TRM1 COG1867
tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N, ...
 103-195 3.93e-06

tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N,N-dimethylase Trm1 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441472  Cd Length: 383  Bit Score: 47.56  E-value: 3.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 103 LALEELRRVEKP--RVLDVGTGTGALALGLKAAIPqAEVTATDLSPEALSLARENAALSGL-DVKFVEG---SLLAGLSG 176
Cdd:COG1867   46 AALRAYRERLKReiSYLDALAASGIRGLRYALEVG-IKVTLNDIDPEAVELIRENLELNGLeDVEVYNRdanALLHELGR 124

                         90       100
                 ....*....|....*....|....
gi 499189351 177 PFNLIVSNP-----PYLPTADRAT 195
Cdd:COG1867  125 RFDVVDLDPfgspaPFIDSALRAA 148
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 105-182 5.33e-06

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 46.37  E-value: 5.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 105 LEELRRVEKPRVLDVGTGTGALALGLKAAipQAEVTATDLSPEALSLARENAALSGLD--VKFVEGSlLAGLSGPFNLIV 182
Cdd:PRK07580  56 LPADGDLTGLRILDAGCGVGSLSIPLARR--GAKVVASDISPQMVEEARERAPEAGLAgnITFEVGD-LESLLGRFDTVV 132
YtxK COG0827
Adenine-specific DNA N6-methylase [Replication, recombination and repair];
84-194 5.88e-06

Adenine-specific DNA N6-methylase [Replication, recombination and repair];


Pssm-ID: 440589 [Multi-domain]  Cd Length: 327  Bit Score: 46.87  E-value: 5.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  84 LTSDARALvprpeteWLLHLaLEELRRVEKPRVLDVGTGTGALalgLKAAIPQ----AEVTATDLSPEALSLARENAALS 159
Cdd:COG0827   95 MTPDAIGL-------LIGYL-VEKFTKKEGLRILDPAVGTGNL---LTTVLNQlkkkVNAYGVEVDDLLIRLAAVLANLQ 163

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 499189351 160 GLDVKFV-EGSLLAGLSGPFNLIVSNPP--YLPTADRA 194
Cdd:COG0827  164 GHPVELFhQDALQPLLIDPVDVVISDLPvgYYPNDERA 201
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 110-172 8.31e-06

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 45.72  E-value: 8.31e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499189351  110 RVEKP-RVLDVGTGTGALALGLKAAIPQ-AEVTATDLSPEALSLARENAALSgLDVKFVEGSLLA 172
Cdd:TIGR01934  36 GVFKGqKVLDVACGTGDLAIELAKSAPDrGKVTGVDFSSEMLEVAKKKSELP-LNIEFIQADAEA 99
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 95-181 8.33e-06

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 45.18  E-value: 8.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  95 PETEWLLHLALeelrRVEKP-RVLDVGTGTG--ALALgLKAAIPQAEVTATDLSPEALSLARENAALSGLD--VKFVEGS 169
Cdd:COG4122    2 PEQGRLLYLLA----RLLGAkRILEIGTGTGysTLWL-ARALPDDGRLTTIEIDPERAAIARENFARAGLAdrIRLILGD 76

                         90
                 ....*....|....*.
gi 499189351 170 ---LLAGL-SGPFNLI 181
Cdd:COG4122   77 aleVLPRLaDGPFDLV 92
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
103-168 9.20e-06

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 45.38  E-value: 9.20e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499189351 103 LALEELRRVEKPRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSGLD-VKFVEG 168
Cdd:PRK08287  22 LALSKLELHRAKHLIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKENRQRFGCGnIDIIPG 88
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
110-187 9.88e-06

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 44.92  E-value: 9.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  110 RVEKPRVLDVGTGTGalALGLKAAIPQAE-VTATDLSPEALSLARENAALSGL-DVKFVEGSLLAGL-----SGPFNLIV 182
Cdd:pfam03602  39 YIEGARVLDLFAGSG--ALGLEALSRGAKrVTLVEKDKRAVQILKENLQLLGLpGAVLVMDALLALLrlagkGPVFDIVF 116


                  ....*
gi 499189351  183 SNPPY 187
Cdd:pfam03602 117 LDPPY 121
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 117-170 2.90e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 41.88  E-value: 2.90e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 499189351  117 LDVGTGTGALALGLKAAIPQaeVTATDLSPEALSLARENAALSGLdvKFVEGSL 170
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR--VTGVDISPEMLELAREKAPREGL--TFVVGDA 50
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 115-186 3.51e-05

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 44.79  E-value: 3.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 115 RVLDV--GTGTGALALGLKAAipqAEVTATDLSPEALSLARENAALSGLD--VKFVEGSLLAGL------SGPFNLIVSN 184
Cdd:COG1092  219 RVLNLfsYTGGFSVHAAAGGA---KSVTSVDLSATALEWAKENAALNGLDdrHEFVQADAFDWLrelareGERFDLIILD 295


                 ..
gi 499189351 185 PP 186
Cdd:COG1092  296 PP 297
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
108-183 7.84e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 43.10  E-value: 7.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 108 LRRVEKP--RVLDVGTGTGALALgLKAAIPQAEVTATDLSPEALSLARENAALSGLD--VKFVEG-SLLAGLSGPFNLIV 182
Cdd:COG4076   29 IERVVKPgdVVLDIGTGSGLLSM-LAARAGAKKVYAVEVNPDIAAVARRIIAANGLSdrITVINAdATDLDLPEKADVII 107


                 .
gi 499189351 183 S 183
Cdd:COG4076  108 S 108
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 115-168 9.32e-05

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 43.34  E-value: 9.32e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499189351 115 RVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSglDVKFVEG 168
Cdd:PLN02490 116 KVVDVGGGTGFTTLGIVKHVDAKNVTILDQSPHQLAKAKQKEPLK--ECKIIEG 167
PRK06202 PRK06202
hypothetical protein; Provisional
 100-184 9.43e-05

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 42.68  E-value: 9.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 100 LLHLALEELRRVekpRVLDVGTGTGALALGLKAAIP----QAEVTATDLSPEALSLARENAALSGLDVKFVEGSLLAGLS 175
Cdd:PRK06202  51 LLRPALSADRPL---TLLDIGCGGGDLAIDLARWARrdglRLEVTAIDPDPRAVAFARANPRRPGVTFRQAVSDELVAEG 127


                 ....*....
gi 499189351 176 GPFNLIVSN 184
Cdd:PRK06202 128 ERFDVVTSN 136
PRK04338 PRK04338
N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional
 103-166 1.58e-04

N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional


Pssm-ID: 235286  Cd Length: 382  Bit Score: 42.59  E-value: 1.58e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499189351 103 LALEELR-RVEKPRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSGLDVKFV 166
Cdd:PRK04338  47 LVLRAFGpKLPRESVLDALSASGIRGIRYALETGVEKVTLNDINPDAVELIKKNLELNGLENEKV 111
PRK08317 PRK08317
hypothetical protein; Provisional
 115-169 1.60e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 42.23  E-value: 1.60e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 499189351 115 RVLDVGTGTGALALGLKAAI-PQAEVTATDLSPEALSLARENAALSGLDVKFVEGS 169
Cdd:PRK08317  22 RVLDVGCGPGNDARELARRVgPEGRVVGIDRSEAMLALAKERAAGLGPNVEFVRGD 77
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 135-187 1.80e-04

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 42.40  E-value: 1.80e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 499189351 135 PQAEVTATDLSPEALSLARENAALSGLD--VKFVEGSLLAgLSGPFN--LIVSNPPY 187
Cdd:COG0116  249 PPLPIFGSDIDPRAIEAARENAERAGVAdlIEFEQADFRD-LEPPAEpgLIITNPPY 304
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 103-169 2.05e-04

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 40.39  E-value: 2.05e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499189351  103 LALEELRRVEKPRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSGL-DVKFVEGS 169
Cdd:TIGR02469  10 LTLAKLRLRPGDVLWDIGAGTGSVTIEAARLVPNGRVYAIERNPEALDLIERNLRRFGVsNIVIVEGD 77
PRK15001 PRK15001
23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;
116-187 2.45e-04

23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;


Pssm-ID: 184963 [Multi-domain]  Cd Length: 378  Bit Score: 41.94  E-value: 2.45e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499189351 116 VLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALS---GLD-VKFVEGSLLAGLSgP--FNLIVSNPPY 187
Cdd:PRK15001 232 IVDLGCGNGVIGLTLLDKNPQAKVVFVDESPMAVASSRLNVETNmpeALDrCEFMINNALSGVE-PfrFNAVLCNPPF 308
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 115-182 2.73e-04

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 41.30  E-value: 2.73e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499189351 115 RVLDVGTGTGALALGLKAAI-PQAEVTATDLSPEALSLARENAALSGLD--VKFVEGSLLAGLS-GPFNLIV 182
Cdd:COG2519   94 RVLEAGTGSGALTLALARAVgPEGKVYSYERREDFAEIARKNLERFGLPdnVELKLGDIREGIDeGDVDAVF 165
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 100-184 4.27e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 40.10  E-value: 4.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351  100 LLHLALEELRRveKPRVLDVGTGTGALALGLKAAipQAEVTATDLSPEALSLARENAALSGLDVkfvegSLLAGLSGPFN 179
Cdd:pfam13489  12 LLLRLLPKLPS--PGRVLDFGCGTGIFLRLLRAQ--GFSVTGVDPSPIAIERALLNVRFDQFDE-----QEAAVPAGKFD 82


                  ....*
gi 499189351  180 LIVSN 184
Cdd:pfam13489  83 VIVAR 87
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 115-202 8.51e-04

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 40.23  E-value: 8.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 115 RVLDVGTGTGALALGLKAAIPqAEVTATDLSPEALSLARENAALSGLD--VKFVEG---SLLAGLSGPFNLIVSNPP--- 186
Cdd:COG2520  183 RVLDMFAGVGPFSIPIAKRSG-AKVVAIDINPDAVEYLKENIRLNKVEdrVTPILGdarEVAPELEGKADRIIMNLPhsa 261

                         90
                 ....*....|....*...
gi 499189351 187 --YLPTADRATADPEVRH 202
Cdd:COG2520  262 deFLDAALRALKPGGVIH 279
PRK05785 PRK05785
hypothetical protein; Provisional
 108-152 2.07e-03

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 38.52  E-value: 2.07e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 499189351 108 LRRVEKP-RVLDVGTGTGALALGLKaAIPQAEVTATDLSPEALSLA 152
Cdd:PRK05785  46 LKYCGRPkKVLDVAAGKGELSYHFK-KVFKYYVVALDYAENMLKMN 90
PRK15128 PRK15128
23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;
109-186 3.30e-03

23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;


Pssm-ID: 185082 [Multi-domain]  Cd Length: 396  Bit Score: 38.66  E-value: 3.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 109 RRVEKPRVLDVGTGTGALAL-GLKAAIPQaeVTATDLSPEALSLARENAALSGLDV---KFVEGSLLAGLSG------PF 178
Cdd:PRK15128 217 RYVENKRVLNCFSYTGGFAVsALMGGCSQ--VVSVDTSQEALDIARQNVELNKLDLskaEFVRDDVFKLLRTyrdrgeKF 294


                 ....*...
gi 499189351 179 NLIVSNPP 186
Cdd:PRK15128 295 DVIVMDPP 302
Rsm22 COG5459
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ...
 115-182 4.65e-03

Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 444210 [Multi-domain]  Cd Length: 306  Bit Score: 38.01  E-value: 4.65e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499189351 115 RVLDVGTGTGALALGLKAAIP-QAEVTATDLSPEALSLARENAALSGL----DVKFVEGSLLAGL-SGPFNLIV 182
Cdd:COG5459   83 TVLDVGAGPGTAAWAAADAWPsLLDATLLERSAAALALGRRLARAAANpaleTAEWRLADLAAALpAPPADLVV 156
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 103-175 6.09e-03

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 37.08  E-value: 6.09e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499189351 103 LALEELRRVEKPRVLDVGTGTGALAlgLKAAIPQAE---VTATDLSPEALSLARENAALSGL--DVKFVEGSLLAGLS 175
Cdd:PRK00377  31 LALSKLRLRKGDMILDIGCGTGSVT--VEASLLVGEtgkVYAVDKDEKAINLTRRNAEKFGVlnNIVLIKGEAPEILF 106
PRK07402 PRK07402
precorrin-6Y C5,15-methyltransferase subunit CbiT;
103-169 7.03e-03

precorrin-6Y C5,15-methyltransferase subunit CbiT;


Pssm-ID: 180961  Cd Length: 196  Bit Score: 36.90  E-value: 7.03e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499189351 103 LALEELRRVEKPRVLDVGTGTGALALGLKAAIPQAEVTATDLSPEALSLARENAALSGLD-VKFVEGS 169
Cdd:PRK07402  31 LLISQLRLEPDSVLWDIGAGTGTIPVEAGLLCPKGRVIAIERDEEVVNLIRRNCDRFGVKnVEVIEGS 98
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 115-187 8.63e-03

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 36.21  E-value: 8.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499189351 115 RVLDVGTGTGalALGLKA----AipqAEVTATDLSPEALSLARENAALSGLD--VKFVEG---SLLAGLSG-PFNLIVSN 184
Cdd:COG0742   44 RVLDLFAGSG--ALGLEAlsrgA---ASVVFVEKDRKAAAVIRKNLEKLGLEdrARVIRGdalRFLKRLAGePFDLVFLD 118


                 ...
gi 499189351 185 PPY 187
Cdd:COG0742  119 PPY 121
rlmL PRK11783
bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2)) ...
 141-187 9.96e-03

bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL;


Pssm-ID: 236981 [Multi-domain]  Cd Length: 702  Bit Score: 37.09  E-value: 9.96e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499189351 141 ATDLSPEALSLARENAALSGLD--VKFVEGSLLAgLSGPFN-----LIVSNPPY 187
Cdd:PRK11783 261 GSDIDPRVIQAARKNARRAGVAelITFEVKDVAD-LKNPLPkgptgLVISNPPY 313
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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