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Conserved domains on  [gi|499192070|ref|WP_010889610|]
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chemotaxis protein CheW [Deinococcus radiodurans]

Protein Classification

chemotaxis protein CheW( domain architecture ID 10481941)

CheW couples methyl-accepting chemoreceptors and histidine kinase CheA and is essential for chemotaxis

Gene Ontology:  GO:0007165|GO:0006935
PubMed:  10049806|12011495

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CheW pfam01584
CheW-like domain; CheW proteins are part of the chemotaxis signaling mechanism in bacteria. ...
 5-134 1.56e-15

CheW-like domain; CheW proteins are part of the chemotaxis signaling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis. The CheW-like regulatory domain in CheA binds to CheW, suggesting that these domains can interact with each other.


:

Pssm-ID: 460257 [Multi-domain]  Cd Length: 131  Bit Score: 68.00  E-value: 1.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499192070    5 LLLFRVGERVLALPAAAARQVRPLDILSPLPGSGGALLGLSSAAGRVVPVADLRALLDWPADTSDQHkdrraPLLLLLDI 84
Cdd:pfam01584   1 GLLFRLGGETFAIPISKVREILRPPPITPIPGAPGYVLGVINLRGEVLPVIDLRRLLGLPPTEPRER-----TRVVVVEV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 499192070   85 QDQTLGLPVDDVIGFTE----DPQTPGDELLSSETLLGSFQ--DGHRGHLLHPELL 134
Cdd:pfam01584  76 GGQVVGLLVDEVIGVLEivikQIEPPLGLGRVAGYISGATIlgDGRVVLILDVEAL 131
 
Name Accession Description Interval E-value
CheW pfam01584
CheW-like domain; CheW proteins are part of the chemotaxis signaling mechanism in bacteria. ...
 5-134 1.56e-15

CheW-like domain; CheW proteins are part of the chemotaxis signaling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis. The CheW-like regulatory domain in CheA binds to CheW, suggesting that these domains can interact with each other.


Pssm-ID: 460257 [Multi-domain]  Cd Length: 131  Bit Score: 68.00  E-value: 1.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499192070    5 LLLFRVGERVLALPAAAARQVRPLDILSPLPGSGGALLGLSSAAGRVVPVADLRALLDWPADTSDQHkdrraPLLLLLDI 84
Cdd:pfam01584   1 GLLFRLGGETFAIPISKVREILRPPPITPIPGAPGYVLGVINLRGEVLPVIDLRRLLGLPPTEPRER-----TRVVVVEV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 499192070   85 QDQTLGLPVDDVIGFTE----DPQTPGDELLSSETLLGSFQ--DGHRGHLLHPELL 134
Cdd:pfam01584  76 GGQVVGLLVDEVIGVLEivikQIEPPLGLGRVAGYISGATIlgDGRVVLILDVEAL 131
CheW COG0835
Chemotaxis signal transduction protein CheW [Signal transduction mechanisms];
4-137 8.08e-11

Chemotaxis signal transduction protein CheW [Signal transduction mechanisms];


Pssm-ID: 440597  Cd Length: 151  Bit Score: 56.42  E-value: 8.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499192070   4 SLLLFRVGERVLALPAAAARQVRPLDILSPLPGSGGALLGLSSAAGRVVPVADLRALLDWPAdtSDQHKDRRApllLLLD 83
Cdd:COG0835    9 QYLTFRLGGERYAIPIEKVREILPLPPITPVPGAPPWVLGVINLRGRVVPVIDLRALLGLPP--TEDTERTRI---IVLE 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499192070  84 IQDQTLGLPVDDVIG---FTEDPQTPGDELLSSET---LLGSFQDGHRG-HLLHPELLLSA 137
Cdd:COG0835   84 VGGRVVGLLVDSVSGvvrIDPDDIEPPPELLSGGLapfITGVAKLDDRLiLLLDLEKLLAE 144
CheW_like cd00588
CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. ...
 4-98 2.04e-08

CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis. The CheW-like regulatory domain in the chemotaxis associated histidine kinase CheA binds to CheW, suggesting that these domains can interact with each other.


Pssm-ID: 238331  Cd Length: 136  Bit Score: 49.58  E-value: 2.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499192070   4 SLLLFRVGERVLALPAAAARQVRPLDILSPLPGSGGALLGLSSAAGRVVPVADLRALLDWPADTSDQHKDRraplLLLLD 83
Cdd:cd00588    3 QVLLFRVGDELYAIPIAVVEEILPLPPITRVPNAPDYVLGVINLRGEILPVIDLRRLFGLEAAEPDTDETR----IVVVE 78

                         90
                 ....*....|....*
gi 499192070  84 IQDQTLGLPVDDVIG 98
Cdd:cd00588   79 VGDRKVGLVVDSVLG 93
CheW smart00260
Two component signalling adaptor domain;
5-98 2.20e-08

Two component signalling adaptor domain;


Pssm-ID: 214588 [Multi-domain]  Cd Length: 138  Bit Score: 49.55  E-value: 2.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499192070     5 LLLFRVG-ERVLALPAAAARQVRPLDILSPLPGSGGALLGLSSAAGRVVPVADLRALLDWPADTSDQHKDrraplLLLLD 83
Cdd:smart00260   5 PLTFAIGkDETYAIPIAAVREILRPPPITPIPGAPGYVLGVINLRGEVLPVVDLRRLLGLPPEPPTDETR-----VIVVE 79

                           90
                   ....*....|....*
gi 499192070    84 IQDQTLGLPVDDVIG 98
Cdd:smart00260  80 TGDRKVGLVVDSVLG 94
 
Name Accession Description Interval E-value
CheW pfam01584
CheW-like domain; CheW proteins are part of the chemotaxis signaling mechanism in bacteria. ...
 5-134 1.56e-15

CheW-like domain; CheW proteins are part of the chemotaxis signaling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis. The CheW-like regulatory domain in CheA binds to CheW, suggesting that these domains can interact with each other.


Pssm-ID: 460257 [Multi-domain]  Cd Length: 131  Bit Score: 68.00  E-value: 1.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499192070    5 LLLFRVGERVLALPAAAARQVRPLDILSPLPGSGGALLGLSSAAGRVVPVADLRALLDWPADTSDQHkdrraPLLLLLDI 84
Cdd:pfam01584   1 GLLFRLGGETFAIPISKVREILRPPPITPIPGAPGYVLGVINLRGEVLPVIDLRRLLGLPPTEPRER-----TRVVVVEV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 499192070   85 QDQTLGLPVDDVIGFTE----DPQTPGDELLSSETLLGSFQ--DGHRGHLLHPELL 134
Cdd:pfam01584  76 GGQVVGLLVDEVIGVLEivikQIEPPLGLGRVAGYISGATIlgDGRVVLILDVEAL 131
CheW COG0835
Chemotaxis signal transduction protein CheW [Signal transduction mechanisms];
4-137 8.08e-11

Chemotaxis signal transduction protein CheW [Signal transduction mechanisms];


Pssm-ID: 440597  Cd Length: 151  Bit Score: 56.42  E-value: 8.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499192070   4 SLLLFRVGERVLALPAAAARQVRPLDILSPLPGSGGALLGLSSAAGRVVPVADLRALLDWPAdtSDQHKDRRApllLLLD 83
Cdd:COG0835    9 QYLTFRLGGERYAIPIEKVREILPLPPITPVPGAPPWVLGVINLRGRVVPVIDLRALLGLPP--TEDTERTRI---IVLE 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499192070  84 IQDQTLGLPVDDVIG---FTEDPQTPGDELLSSET---LLGSFQDGHRG-HLLHPELLLSA 137
Cdd:COG0835   84 VGGRVVGLLVDSVSGvvrIDPDDIEPPPELLSGGLapfITGVAKLDDRLiLLLDLEKLLAE 144
CheW_like cd00588
CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. ...
 4-98 2.04e-08

CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis. The CheW-like regulatory domain in the chemotaxis associated histidine kinase CheA binds to CheW, suggesting that these domains can interact with each other.


Pssm-ID: 238331  Cd Length: 136  Bit Score: 49.58  E-value: 2.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499192070   4 SLLLFRVGERVLALPAAAARQVRPLDILSPLPGSGGALLGLSSAAGRVVPVADLRALLDWPADTSDQHKDRraplLLLLD 83
Cdd:cd00588    3 QVLLFRVGDELYAIPIAVVEEILPLPPITRVPNAPDYVLGVINLRGEILPVIDLRRLFGLEAAEPDTDETR----IVVVE 78

                         90
                 ....*....|....*
gi 499192070  84 IQDQTLGLPVDDVIG 98
Cdd:cd00588   79 VGDRKVGLVVDSVLG 93
CheW smart00260
Two component signalling adaptor domain;
5-98 2.20e-08

Two component signalling adaptor domain;


Pssm-ID: 214588 [Multi-domain]  Cd Length: 138  Bit Score: 49.55  E-value: 2.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499192070     5 LLLFRVG-ERVLALPAAAARQVRPLDILSPLPGSGGALLGLSSAAGRVVPVADLRALLDWPADTSDQHKDrraplLLLLD 83
Cdd:smart00260   5 PLTFAIGkDETYAIPIAAVREILRPPPITPIPGAPGYVLGVINLRGEVLPVVDLRRLLGLPPEPPTDETR-----VIVVE 79

                           90
                   ....*....|....*
gi 499192070    84 IQDQTLGLPVDDVIG 98
Cdd:smart00260  80 TGDRKVGLVVDSVLG 94
CheW cd00732
CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. ...
 4-102 1.42e-07

CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together with CheA and the methyl-accepting chemotaxis proteins (MCPs), which are involved in response modulation.


Pssm-ID: 238374  Cd Length: 140  Bit Score: 47.57  E-value: 1.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499192070   4 SLLLFRVGERVLALPAAAARQVRPLDILSPLPGSGGALLGLSSAAGRVVPVADLRALLDWPADTSDQHKDrraplLLLLD 83
Cdd:cd00732    3 EVVTFRLGDEEYGIPIMQVREILKPTPITPIPNAPPYVLGVINLRGRIVPVIDLRKRLGLPPAEDTKNTR-----IIVVE 77

                         90       100
                 ....*....|....*....|..
gi 499192070  84 IQDQTLGLPVD---DVIGFTED 102
Cdd:cd00732   78 VGDQVVGLLVDsvsEVLRLSTD 99
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
6-98 9.53e-03

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 35.16  E-value: 9.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499192070   6 LLFRVGERVLALPAAAARQVRPL--DILSPLPGSGGALLGlssaaGRVVPVADLRALLDWPADTSDQHKD-----RRApl 78
Cdd:COG0643  426 LLVRVGGETYAIPLSSVEEVLRLdpDDIETVEGREVIRLR-----GELLPLVRLGELLGLPGAEPEGERGpvvvvRSG-- 498

                         90       100
                 ....*....|....*....|
gi 499192070  79 lllldiqDQTLGLPVDDVIG 98
Cdd:COG0643  499 -------GRRVALVVDELLG 511
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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