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Conserved domains on  [gi|499322103|ref|WP_011012595|]
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MULTISPECIES: NADH-quinone oxidoreductase subunit K [Pyrococcus]

Protein Classification

Na(+)/H(+) antiporter subunit C; NADH-quinone oxidoreductase subunit NuoK( domain architecture ID 10013068)

Na(+)/H(+) antiporter subunit C (MrpC) is part of a heterooligomeric complex together with MrpA, MrpB, MrpD, MrpE, MrpF and MrpG, which is involved in resistance to Na(+) and excretion of Li(+) and Na(+)| NADH-quinone oxidoreductase subunit K (NuoK) is part of the membrane domain of complex I of the respiratory chain that couples the transfer of electrons from NADH to quinone with the translocation of protons across the membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK08389 PRK08389
putative monovalent cation/H+ antiporter subunit C; Reviewed
 1-114 2.43e-50

putative monovalent cation/H+ antiporter subunit C; Reviewed


:

Pssm-ID: 236258  Cd Length: 114  Bit Score: 154.89  E-value: 2.43e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103   1 MISSYYFGAISLILIGLYAVLVKKNLLKILIGLSIMETGVNLLLISIGYVSGKSAPILSEGVTASNAVDPIPQALVLTAI 80
Cdd:PRK08389   1 MIEAYYFGAIALVLIGLYGVLVKKNLLKIIIGLDIMETGVNLLLISIGYVSGRSAPILSEGITPSNYVDPIPQALVLTAI 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 499322103  81 VIGVATTAMALSVAILLYEKYGTLNIEEIRRLRG 114
Cdd:PRK08389  81 VIGVSTTALALSVAIKLYEKYGTLNVEEIRRLRG 114
 
Name Accession Description Interval E-value
PRK08389 PRK08389
putative monovalent cation/H+ antiporter subunit C; Reviewed
 1-114 2.43e-50

putative monovalent cation/H+ antiporter subunit C; Reviewed


Pssm-ID: 236258  Cd Length: 114  Bit Score: 154.89  E-value: 2.43e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103   1 MISSYYFGAISLILIGLYAVLVKKNLLKILIGLSIMETGVNLLLISIGYVSGKSAPILSEGVTASNAVDPIPQALVLTAI 80
Cdd:PRK08389   1 MIEAYYFGAIALVLIGLYGVLVKKNLLKIIIGLDIMETGVNLLLISIGYVSGRSAPILSEGITPSNYVDPIPQALVLTAI 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 499322103  81 VIGVATTAMALSVAILLYEKYGTLNIEEIRRLRG 114
Cdd:PRK08389  81 VIGVSTTALALSVAIKLYEKYGTLNVEEIRRLRG 114
MnhC COG1006
Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism];
1-114 5.33e-39

Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism];


Pssm-ID: 440630  Cd Length: 113  Bit Score: 126.38  E-value: 5.33e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103   1 MISSYYFGAISLILIGLYaVLVKKNLLKILIGLSIMETGVNLLLISIGYVSGKSAPILSEGVTASNAVDPIPQALVLTAI 80
Cdd:COG1006    1 MELLLALVIGVLFAIGVY-LLLRRNLIKVIIGLSLLSNAVNLLLFAMGGLTGGAPPILGEGPPAAPYADPLPQALVLTAI 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 499322103  81 VIGVATTAMALSVAILLYEKYGTLNIEEIRRLRG 114
Cdd:COG1006   80 VIGFAVTAFLLALAYRIYQLYGTDDVDELREDER 113
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
4-114 1.33e-18

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 74.14  E-value: 1.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103    4 SYYFGAISLILIGLYAVLVKKNLLKILIGLSIMETGVNLLLISIGYVSGksapilsegvtasnavDPIPQALVLTAIVIG 83
Cdd:pfam00420   1 AYLLLSGLLFLIGLYGLLLRRNLLRVLLSLELMLNAVNLALVLFGRLTA----------------DPLPQALILTAIVIA 64

                          90       100       110
                  ....*....|....*....|....*....|.
gi 499322103   84 VATTAMALSVAILLYEKYGTLNIEEIRRLRG 114
Cdd:pfam00420  65 AAEAAVGLALLVRIYRTHGTDDVDSLNLLKG 95
2a6301s03 TIGR00941
Multicomponent Na+:H+ antiporter, MnhC subunit; [Transport and binding proteins, Cations and ...
 1-107 5.14e-13

Multicomponent Na+:H+ antiporter, MnhC subunit; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273354  Cd Length: 104  Bit Score: 59.82  E-value: 5.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103    1 MISSYYFGAISLILIGLYAVLvKKNLLKILIGLSIMETGVNLLLISIGYVSGKSAPILSEGVtaSNAVDPIPQALVLTAI 80
Cdd:TIGR00941   1 MESIFALIIGILTASGVYLLL-SRSVVRVVLGLALLGYAVNLFILTMGGLENKAPPILTLPV--GPYVDPLPQALILTAI 77

                          90       100
                  ....*....|....*....|....*..
gi 499322103   81 VIGVATTAMALSVAILLYEKYGTLNIE 107
Cdd:TIGR00941  78 VIGFATTALFLVVALRAYQVAGTDDVE 104
 
Name Accession Description Interval E-value
PRK08389 PRK08389
putative monovalent cation/H+ antiporter subunit C; Reviewed
 1-114 2.43e-50

putative monovalent cation/H+ antiporter subunit C; Reviewed


Pssm-ID: 236258  Cd Length: 114  Bit Score: 154.89  E-value: 2.43e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103   1 MISSYYFGAISLILIGLYAVLVKKNLLKILIGLSIMETGVNLLLISIGYVSGKSAPILSEGVTASNAVDPIPQALVLTAI 80
Cdd:PRK08389   1 MIEAYYFGAIALVLIGLYGVLVKKNLLKIIIGLDIMETGVNLLLISIGYVSGRSAPILSEGITPSNYVDPIPQALVLTAI 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 499322103  81 VIGVATTAMALSVAILLYEKYGTLNIEEIRRLRG 114
Cdd:PRK08389  81 VIGVSTTALALSVAIKLYEKYGTLNVEEIRRLRG 114
MnhC COG1006
Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism];
1-114 5.33e-39

Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism];


Pssm-ID: 440630  Cd Length: 113  Bit Score: 126.38  E-value: 5.33e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103   1 MISSYYFGAISLILIGLYaVLVKKNLLKILIGLSIMETGVNLLLISIGYVSGKSAPILSEGVTASNAVDPIPQALVLTAI 80
Cdd:COG1006    1 MELLLALVIGVLFAIGVY-LLLRRNLIKVIIGLSLLSNAVNLLLFAMGGLTGGAPPILGEGPPAAPYADPLPQALVLTAI 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 499322103  81 VIGVATTAMALSVAILLYEKYGTLNIEEIRRLRG 114
Cdd:COG1006   80 VIGFAVTAFLLALAYRIYQLYGTDDVDELREDER 113
PRK07375 PRK07375
Na+/H+ antiporter subunit C;
1-113 6.56e-32

Na+/H+ antiporter subunit C;


Pssm-ID: 236004  Cd Length: 112  Bit Score: 108.43  E-value: 6.56e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103   1 MISSYYFGAISLILIGLYAVLVKKNLLKILIGLSIMETGVNLLLISIGYVSGKSAPILSEGVtASNAVDPIPQALVLTAI 80
Cdd:PRK07375   1 MQLMIYALAIALLVIGLYGLIFKRNLLKKIIGLDVFQTGVNLFYIAIGYRSGGGVPILSPSG-FTTYADPLPQALVLTAI 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 499322103  81 VIGVATTAMALSVAILLYEKYGTLNIEEIRRLR 113
Cdd:PRK07375  80 VIGFATTAVMLALIVKLYKDYGTLSESEIEKED 112
PRK08388 PRK08388
putative monovalent cation/H+ antiporter subunit C; Reviewed
 1-114 4.52e-22

putative monovalent cation/H+ antiporter subunit C; Reviewed


Pssm-ID: 236257  Cd Length: 119  Bit Score: 83.41  E-value: 4.52e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103   1 MISSYYFGAISLILIGLYAVLVKKNLLKILIGLSIMETGVNLLLISIGYV----SGKSAPILSEGVTASNA-VDPIPQAL 75
Cdd:PRK08388   1 MIAFQFITAFLMIALGIYAFLYKRNLIKLILALDLIDSGIHLLLISLGYRmengLPPTAPIYTGYETLKSPmVGPIPQAL 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 499322103  76 VLTAIVIGVATTAMALSVAILLYEKYGTLNIEEIRRLRG 114
Cdd:PRK08388  81 VLTSIVIGVCVLSLAMALTINAYRHYGTLDVTKLRRLRG 119
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
4-114 1.33e-18

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 74.14  E-value: 1.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103    4 SYYFGAISLILIGLYAVLVKKNLLKILIGLSIMETGVNLLLISIGYVSGksapilsegvtasnavDPIPQALVLTAIVIG 83
Cdd:pfam00420   1 AYLLLSGLLFLIGLYGLLLRRNLLRVLLSLELMLNAVNLALVLFGRLTA----------------DPLPQALILTAIVIA 64

                          90       100       110
                  ....*....|....*....|....*....|.
gi 499322103   84 VATTAMALSVAILLYEKYGTLNIEEIRRLRG 114
Cdd:pfam00420  65 AAEAAVGLALLVRIYRTHGTDDVDSLNLLKG 95
PRK08600 PRK08600
putative monovalent cation/H+ antiporter subunit C; Reviewed
 12-110 4.49e-18

putative monovalent cation/H+ antiporter subunit C; Reviewed


Pssm-ID: 181497  Cd Length: 113  Bit Score: 73.07  E-value: 4.49e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103  12 LILIGLYAVLvKKNLLKILIGLSIMETGVNLLLISIGYVSGKSAPILSEGVTASnaVDPIPQALVLTAIVIGVATTAMAL 91
Cdd:PRK08600  12 LTAIAVYLIL-SKSLLRIIIGTTLLSHGANLLLLTMGGLKKGAVPILGEGVTSY--VDPLPQALILTAIVISFGVTAFFL 88

                         90
                 ....*....|....*....
gi 499322103  92 SVAILLYEKYGTLNIEEIR 110
Cdd:PRK08600  89 VLAYRTYKELGTDNVEQMR 107
PRK12658 PRK12658
Na+/H+ antiporter subunit C;
13-111 1.52e-15

Na+/H+ antiporter subunit C;


Pssm-ID: 183658  Cd Length: 125  Bit Score: 67.01  E-value: 1.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103  13 ILIGLYA-----VLVKKNLLKILIGLSIMETGVNLLLISIGYVSGKSAPILSEG--VTASNAVDPIPQALVLTAIVIGVA 85
Cdd:PRK12658   7 ILVGVFFaaaiyLMLSRHIIRILFGLALLGNAVNLLIFTAGRLTREVPPLIPAGadVLAEGAANPLPQALILTAIVIGFG 86

                         90       100
                 ....*....|....*....|....*.
gi 499322103  86 TTAMALSVAILLYEKYGTLNIEEIRR 111
Cdd:PRK12658  87 LLAFLLVLAYRAYQDLGTDDTDEMRV 112
PRK09094 PRK09094
putative monovalent cation/H+ antiporter subunit C; Reviewed
 29-95 1.54e-15

putative monovalent cation/H+ antiporter subunit C; Reviewed


Pssm-ID: 236377  Cd Length: 114  Bit Score: 66.83  E-value: 1.54e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499322103  29 ILIGLSIMETGVNLLLISIGYVSGKSAPILSEGVTASNA--VDPIPQALVLTAIVIGVATTAMALSVAI 95
Cdd:PRK09094  28 VILGLSLLSYAVNLFIFAMGRLRVGAPPVLQPGVPVDLAnyTDPLPQALVLTAIVIGFAMTALFLVVAL 96
PRK12660 PRK12660
putative monovalent cation/H+ antiporter subunit C; Reviewed
 12-114 4.24e-15

putative monovalent cation/H+ antiporter subunit C; Reviewed


Pssm-ID: 183660  Cd Length: 114  Bit Score: 65.53  E-value: 4.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103  12 LILIGLYAVLvKKNLLKILIGLSIMETGVNLLLISIG-YVSGKSAPILSEGvtASNAVDPIPQALVLTAIVIGVATTAMA 90
Cdd:PRK12660  12 LVFIGTYMIL-SINLIRIVIGISIYTHAGNLIIMSMGgYGSSRSEPLITGG--NQLFVDPLLQAIVLTAIVIGFGMTAFL 88

                         90       100
                 ....*....|....*....|....
gi 499322103  91 LsvaILLYEKYGTLNIEEIRRLRG 114
Cdd:PRK12660  89 L---VLVYRTYKVTKEDEIEGLRG 109
PRK12661 PRK12661
putative monovalent cation/H+ antiporter subunit C; Reviewed
 13-114 5.80e-15

putative monovalent cation/H+ antiporter subunit C; Reviewed


Pssm-ID: 237162  Cd Length: 140  Bit Score: 65.95  E-value: 5.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103  13 ILIGLYAVLV-KKNLLKILIGLSIMETGVNLLLISIGYVSGKSAPILSEG--------------------------VTAS 65
Cdd:PRK12661  12 LLFGIGTFLIlRRDMIKVIIGLSIISHAVNLLIVSSGVFEGTKVPIITEQghegsgsgiiyndnltsgilapivtnGPET 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 499322103  66 NAVDPIPQALVLTAIVIGVATTAMALSVAILLYEKYGTLNIEEIRRLRG 114
Cdd:PRK12661  92 EFVDPLVQALVLTAIVIGLATTAFILILAYRIYEEYGTTDIRELRRLRG 140
PRK07946 PRK07946
putative monovalent cation/H+ antiporter subunit C; Reviewed
 12-94 2.10e-13

putative monovalent cation/H+ antiporter subunit C; Reviewed


Pssm-ID: 236136  Cd Length: 163  Bit Score: 62.37  E-value: 2.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103  12 LILIG-LYAV----LVKKNLLKILIGLSIMETGVNLLLISIGYVSGkSAPILSEGVTASNAV-DPIPQALVLTAIVIGVA 85
Cdd:PRK07946   8 LVAIGvLTSAgvylLLERSLTRMLLGLLLIGNGVNLLILTAGGPAG-NPPILGRTSEYGETMaDPLAQAMILTAIVITMG 86


                 ....*....
gi 499322103  86 TTAMALSVA 94
Cdd:PRK07946  87 ITAFVLALA 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 2-114 4.46e-13

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 60.08  E-value: 4.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103   2 ISSYYFGAISLILIGLYAVLVKKNLLKILIGLSIMETGVNLLLISIGYVSGksapilsegvtasnavDPIPQALVLTAIV 81
Cdd:COG0713    3 LEHYLILAAILFAIGLYGVLTRRNLIVVLMSIELMLNAVNLNLVAFSRYLG----------------DLDGQVFALFVIA 66

                         90       100       110
                 ....*....|....*....|....*....|...
gi 499322103  82 IGVATTAMALSVAILLYEKYGTLNIEEIRRLRG 114
Cdd:COG0713   67 VAAAEVAVGLAIIVALYRNRGTIDVDDLNELKG 99
2a6301s03 TIGR00941
Multicomponent Na+:H+ antiporter, MnhC subunit; [Transport and binding proteins, Cations and ...
 1-107 5.14e-13

Multicomponent Na+:H+ antiporter, MnhC subunit; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273354  Cd Length: 104  Bit Score: 59.82  E-value: 5.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103    1 MISSYYFGAISLILIGLYAVLvKKNLLKILIGLSIMETGVNLLLISIGYVSGKSAPILSEGVtaSNAVDPIPQALVLTAI 80
Cdd:TIGR00941   1 MESIFALIIGILTASGVYLLL-SRSVVRVVLGLALLGYAVNLFILTMGGLENKAPPILTLPV--GPYVDPLPQALILTAI 77

                          90       100
                  ....*....|....*....|....*..
gi 499322103   81 VIGVATTAMALSVAILLYEKYGTLNIE 107
Cdd:TIGR00941  78 VIGFATTALFLVVALRAYQVAGTDDVE 104
PRK12659 PRK12659
Na+/H+ antiporter subunit C;
10-110 6.95e-11

Na+/H+ antiporter subunit C;


Pssm-ID: 183659  Cd Length: 117  Bit Score: 54.67  E-value: 6.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103  10 ISLILIGLYA----VLVKKNLLKILIGLSIMETGVNLLLISIGYVSGKSAPILSEGVTASNA--VDPIPQALVLTAIVIG 83
Cdd:PRK12659   5 LAIVVGGLYAagiyMMLRRSIVKLVIGLILLGNAANLLIFTVGRLTRGAPPLVPEGATAPAGpvADPLPQALILTAIVIG 84

                         90       100
                 ....*....|....*....|....*..
gi 499322103  84 VATTAMALSVAILLYEKYGTLNIEEIR 110
Cdd:PRK12659  85 FGVQAFAIVLIKRAYQVVGTDDLDEMK 111
PRK05715 PRK05715
NADH-quinone oxidoreductase subunit NuoK;
1-114 9.64e-08

NADH-quinone oxidoreductase subunit NuoK;


Pssm-ID: 180218  Cd Length: 100  Bit Score: 46.32  E-value: 9.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499322103   1 MISSYYFGAISLIL--IGLYAVLVKKNLLKILIGLSIMETGVNLLLISIGYVSGksapilsegvtasnavDPIPQALVLT 78
Cdd:PRK05715   1 MIPLQHYLILAAILfcIGLVGLLLRRNAIVVLMSIELMLNAVNLNFVAFSSYLG----------------DLDGQVFAFF 64

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 499322103  79 AIVIGVATTAMALSVAILLYEKYGTLNIEEIRRLRG 114
Cdd:PRK05715  65 VITVAAAEAAIGLAILLQLYRNRGTIDVDDLNELKG 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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