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Conserved domains on  [gi|499371893|ref|WP_011059471|]
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MULTISPECIES: GNAT family N-acetyltransferase [Pseudomonas]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
yhbS super family cl43796
Predicted N-acetyltransferase YhbS [General function prediction only];
45-176 2.31e-07

Predicted N-acetyltransferase YhbS [General function prediction only];


The actual alignment was detected with superfamily member COG3153:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 47.77  E-value: 2.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499371893  45 QGWPEGEAEHDALILQQCYRRGGWLYGVFDGpALVAAVVVDCLPIACAGLDLrQLKFLHVSQAYRGLGLGRQLFALAREQ 124
Cdd:COG3153   18 AAFGPGREAELVDRLREDPAAGLSLVAEDDG-EIVGHVALSPVDIDGEGPAL-LLGPLAVDPEYRGQGIGRALMRAALEA 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499371893 125 ALVLGGQGLYVSATPSRHtvDFYMRLGCELLATPDpqlLRIEPEDIHLYLRL 176
Cdd:COG3153   96 ARERGARAVVLLGDPSLL--PFYERFGFRPAGELG---LTLGPDEVFLAKEL 142
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
45-176 2.31e-07

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 47.77  E-value: 2.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499371893  45 QGWPEGEAEHDALILQQCYRRGGWLYGVFDGpALVAAVVVDCLPIACAGLDLrQLKFLHVSQAYRGLGLGRQLFALAREQ 124
Cdd:COG3153   18 AAFGPGREAELVDRLREDPAAGLSLVAEDDG-EIVGHVALSPVDIDGEGPAL-LLGPLAVDPEYRGQGIGRALMRAALEA 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499371893 125 ALVLGGQGLYVSATPSRHtvDFYMRLGCELLATPDpqlLRIEPEDIHLYLRL 176
Cdd:COG3153   96 ARERGARAVVLLGDPSLL--PFYERFGFRPAGELG---LTLGPDEVFLAKEL 142
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 102-151 4.82e-06

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 43.80  E-value: 4.82e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 499371893  102 LHVSQAYRGLGLGRQLFALAREQALVLGGQGLYVSATPSRHTVDFYMRLG 151
Cdd:pfam13673  57 LFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTVNASPYAVPFYEKLG 106
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 69-136 9.22e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 33.40  E-value: 9.22e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499371893  69 LYGVFDGPALVAAVVVDCLPIACAGLDLRqlkFLHVSQAYRGLGLGRQLFALAREQALVLGGQGLYVS 136
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGSGGDTAYIG---DLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
45-176 2.31e-07

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 47.77  E-value: 2.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499371893  45 QGWPEGEAEHDALILQQCYRRGGWLYGVFDGpALVAAVVVDCLPIACAGLDLrQLKFLHVSQAYRGLGLGRQLFALAREQ 124
Cdd:COG3153   18 AAFGPGREAELVDRLREDPAAGLSLVAEDDG-EIVGHVALSPVDIDGEGPAL-LLGPLAVDPEYRGQGIGRALMRAALEA 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499371893 125 ALVLGGQGLYVSATPSRHtvDFYMRLGCELLATPDpqlLRIEPEDIHLYLRL 176
Cdd:COG3153   96 ARERGARAVVLLGDPSLL--PFYERFGFRPAGELG---LTLGPDEVFLAKEL 142
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 88-176 2.95e-06

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 44.60  E-value: 2.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499371893  88 PIACAGL-----DLRQLKFLHVSQAYRGLGLGRQLFALAREQALVLGGQGLYVSATpsRHTVDFYMRLGCELLATPD-PQ 161
Cdd:COG1246   39 IVGCAALhpldeDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTT--SAAIHFYEKLGFEEIDKEDlPY 116

                         90
                 ....*....|....*
gi 499371893 162 LLRIEPEDIHLYLRL 176
Cdd:COG1246  117 AKVWQRDSVVMEKDL 131
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 102-151 4.82e-06

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 43.80  E-value: 4.82e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 499371893  102 LHVSQAYRGLGLGRQLFALAREQALVLGGQGLYVSATPSRHTVDFYMRLG 151
Cdd:pfam13673  57 LFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTVNASPYAVPFYEKLG 106
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
104-151 4.00e-05

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 41.32  E-value: 4.00e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 499371893 104 VSQAYRGLGLGRQLFALAREQALVLGGQGLYVSAtpSRHTVDFYMRLG 151
Cdd:COG2153   66 VLPEYRGQGLGRALMEAAIEEARERGARRIVLSA--QAHAVGFYEKLG 111
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 99-151 3.16e-04

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 38.10  E-value: 3.16e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499371893  99 LKFLHVSQAYRGLGLGRQLFALAREQALVLGGQGLYVSATPSRHT-VDFYMRLG 151
Cdd:COG0456   16 IEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAaIALYEKLG 69
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 74-151 4.75e-04

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 38.50  E-value: 4.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499371893  74 DGPALVAAVVVDCLPIACAGL-----DLRQLKFLHVSQAYRGLGLGRQLFALAREQALVLGGQGLYVSA-TPSRHTVDFY 147
Cdd:COG0454   31 LAGAEFIAVDDKGEPIGFAGLrrlddKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTlDGNPAAIRFY 110


                 ....
gi 499371893 148 MRLG 151
Cdd:COG0454  111 ERLG 114
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 69-151 1.94e-03

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 35.89  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499371893   69 LYGVFDGPALVAAVVVDCLPIACAGLDLRqlkfLHVSQAYRGLGLGRQLFALAREQALVLGGQGLYVSATpsRHTVDFYM 148
Cdd:pfam13508   5 FFVAEDDGKIVGFAALLPLDDEGALAELR----LAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETT--NRAAAFYE 78


                  ...
gi 499371893  149 RLG 151
Cdd:pfam13508  79 KLG 81
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 99-151 3.37e-03

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 35.57  E-value: 3.37e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 499371893   99 LKFLHVSQAYRGLGLGRQLFALAREQALVLGGQGLYVSATPSRH-TVDFYMRLG 151
Cdd:pfam00583  62 IEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLaAIALYEKLG 115
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
102-151 4.69e-03

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 36.13  E-value: 4.69e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 499371893 102 LHVSQAYRGLGLGRQLFALAREQALVLGGQGLYVSATPSRHT-VDFYMRLG 151
Cdd:COG1247   86 IYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEAsIALYEKLG 136
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 69-136 9.22e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 33.40  E-value: 9.22e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499371893  69 LYGVFDGPALVAAVVVDCLPIACAGLDLRqlkFLHVSQAYRGLGLGRQLFALAREQALVLGGQGLYVS 136
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGSGGDTAYIG---DLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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