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Conserved domains on  [gi|499376460|ref|WP_011064038|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [Pseudomonas]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 10451993)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 61-204 1.50e-49

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


:

Pssm-ID: 433616  Cd Length: 143  Bit Score: 158.56  E-value: 1.50e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499376460   61 YESLVDSFLRPPPGRAVTVQDKRYYLQALLAAMWRYRFLHRDLEHLLDSDPELAARYRRFSQRCLIQGMAIYGRFVDAGI 140
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499376460  141 VAMDKVQIESLTLNAWIILTSWVRFLCtTRENSTHLSEEAIKRGVYQVLVLEAGFVTDQAREAV 204
Cdd:pfam13972  81 LQADDEELEALADNIWLVATYWLSYQR-TQAPEAALTEAALRRGVYQVLSLLAPYLTPEGREAF 143
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
16-55 9.50e-07

Bacterial regulatory proteins, tetR family;


:

Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 44.32  E-value: 9.50e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 499376460   16 LELFNQQGERNVSTNHIAAHMEISPGNLYYHFPNKQAIIA 55
Cdd:pfam00440   6 RELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLE 45
 
Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 61-204 1.50e-49

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


Pssm-ID: 433616  Cd Length: 143  Bit Score: 158.56  E-value: 1.50e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499376460   61 YESLVDSFLRPPPGRAVTVQDKRYYLQALLAAMWRYRFLHRDLEHLLDSDPELAARYRRFSQRCLIQGMAIYGRFVDAGI 140
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499376460  141 VAMDKVQIESLTLNAWIILTSWVRFLCtTRENSTHLSEEAIKRGVYQVLVLEAGFVTDQAREAV 204
Cdd:pfam13972  81 LQADDEELEALADNIWLVATYWLSYQR-TQAPEAALTEAALRRGVYQVLSLLAPYLTPEGREAF 143
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-123 3.81e-16

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 72.62  E-value: 3.81e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499376460   1 MAPRIKTRERIVQFSLELFNQQGERNVSTNHIAAHMEISPGNLYYHFPNKQAIIAVLFAEYESLVDSFLRPPPGRAVTVQ 80
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 499376460  81 DKRYYLQALLAAMWRYRFLHRDLEHLLDSDPELAARYRRFSQR 123
Cdd:COG1309   81 RLRALLRAYLEFLAENPALARLLLAEAAELPELRAALRALLRR 123
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
16-55 9.50e-07

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 44.32  E-value: 9.50e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 499376460   16 LELFNQQGERNVSTNHIAAHMEISPGNLYYHFPNKQAIIA 55
Cdd:pfam00440   6 RELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLE 45
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
5-118 4.43e-06

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 45.66  E-value: 4.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499376460   5 IKTRERIVQFSLELFNQQGERNVSTNHIAAHMEISPGNLYYHFPNKQAI-IAVLFAEYESLvDSFLRPPPGRAVTvqdkr 83
Cdd:NF041196   5 IRTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALaRAVLEEQVARL-REAVEPQRAGGGS----- 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 499376460  84 yYLQALLAAmwryrfLHRdLEHLLDSDPELAARYR 118
Cdd:NF041196  79 -KLQELVDL------THV-LARRLRTDPVVRAGVR 105
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
 8-61 1.25e-03

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 38.66  E-value: 1.25e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499376460   8 RERIVQFSLELFNQQGERNVSTNHIAAHMEISPGNLYYHFPNKQAIIAVLFAEY 61
Cdd:NF037937   1 KEKILDAAISLFNTKGFDGTSVRDIAKKAKVNVALISYYFKGKQGLLEYLVTSF 54
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 1-67 1.77e-03

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 38.06  E-value: 1.77e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499376460   1 MAPRIK-----TRERIVQFSLELFNQQGERNVSTNHIAAHMEISPGNLYYHFPNKqaiiAVLFAEYESLVDS 67
Cdd:PRK10668   1 MARKTKqqaqeTRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNK----SDLFSEIWELSES 68
 
Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 61-204 1.50e-49

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


Pssm-ID: 433616  Cd Length: 143  Bit Score: 158.56  E-value: 1.50e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499376460   61 YESLVDSFLRPPPGRAVTVQDKRYYLQALLAAMWRYRFLHRDLEHLLDSDPELAARYRRFSQRCLIQGMAIYGRFVDAGI 140
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499376460  141 VAMDKVQIESLTLNAWIILTSWVRFLCtTRENSTHLSEEAIKRGVYQVLVLEAGFVTDQAREAV 204
Cdd:pfam13972  81 LQADDEELEALADNIWLVATYWLSYQR-TQAPEAALTEAALRRGVYQVLSLLAPYLTPEGREAF 143
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-123 3.81e-16

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 72.62  E-value: 3.81e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499376460   1 MAPRIKTRERIVQFSLELFNQQGERNVSTNHIAAHMEISPGNLYYHFPNKQAIIAVLFAEYESLVDSFLRPPPGRAVTVQ 80
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 499376460  81 DKRYYLQALLAAMWRYRFLHRDLEHLLDSDPELAARYRRFSQR 123
Cdd:COG1309   81 RLRALLRAYLEFLAENPALARLLLAEAAELPELRAALRALLRR 123
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
16-55 9.50e-07

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 44.32  E-value: 9.50e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 499376460   16 LELFNQQGERNVSTNHIAAHMEISPGNLYYHFPNKQAIIA 55
Cdd:pfam00440   6 RELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLE 45
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
5-118 4.43e-06

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 45.66  E-value: 4.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499376460   5 IKTRERIVQFSLELFNQQGERNVSTNHIAAHMEISPGNLYYHFPNKQAI-IAVLFAEYESLvDSFLRPPPGRAVTvqdkr 83
Cdd:NF041196   5 IRTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALaRAVLEEQVARL-REAVEPQRAGGGS----- 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 499376460  84 yYLQALLAAmwryrfLHRdLEHLLDSDPELAARYR 118
Cdd:NF041196  79 -KLQELVDL------THV-LARRLRTDPVVRAGVR 105
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
1-123 5.93e-05

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 42.23  E-value: 5.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499376460   1 MAPRIKTRERIVQFSLELFNQQGERNVSTNHIAAHMEISPGNLYYHFPNKQAIIAVLFAEYESLVDSFLRPPPGRAVTVQ 80
Cdd:COG3226    3 RRRGEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLE 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 499376460  81 DkryYLQALLAAMWRYRFLHRD-----LEHLLDS--DPELAARYRRFSQR 123
Cdd:COG3226   83 D---AAEALADLLAELLPADRDrllarYELYLEAlrDPELRALLRRWRDR 129
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
 8-61 1.25e-03

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 38.66  E-value: 1.25e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499376460   8 RERIVQFSLELFNQQGERNVSTNHIAAHMEISPGNLYYHFPNKQAIIAVLFAEY 61
Cdd:NF037937   1 KEKILDAAISLFNTKGFDGTSVRDIAKKAKVNVALISYYFKGKQGLLEYLVTSF 54
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 1-67 1.77e-03

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 38.06  E-value: 1.77e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499376460   1 MAPRIK-----TRERIVQFSLELFNQQGERNVSTNHIAAHMEISPGNLYYHFPNKqaiiAVLFAEYESLVDS 67
Cdd:PRK10668   1 MARKTKqqaqeTRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNK----SDLFSEIWELSES 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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