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Conserved domains on  [gi|500000237|ref|WP_011680955|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Streptococcus]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10007659)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
5-69 1.54e-16

DNA-binding transcriptional regulator, XRE family [Transcription];


:

Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 66.32  E-value: 1.54e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500000237  5 YERLWELTLKRRINKTSLRDMAGITNSTLSRLSKDET--VSMEALARLCEALQCQLEEIIEYKLENK 69
Cdd:COG3655   3 YVKLDELLAERGMTKKELAEATGISRATLSRLKNGKAkaVRLDTLEKICKALDCQPGDLLEYVPDEE 69
 
Name Accession Description Interval E-value
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
5-69 1.54e-16

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 66.32  E-value: 1.54e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500000237  5 YERLWELTLKRRINKTSLRDMAGITNSTLSRLSKDET--VSMEALARLCEALQCQLEEIIEYKLENK 69
Cdd:COG3655   3 YVKLDELLAERGMTKKELAEATGISRATLSRLKNGKAkaVRLDTLEKICKALDCQPGDLLEYVPDEE 69
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 7-65 7.57e-14

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 59.48  E-value: 7.57e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 500000237   7 RLWELTLKRRINKTSLRDMAGITNSTLSRLSKDE--TVSMEALARLCEALQCQLEEIIEYK 65
Cdd:pfam13443  1 KLRKLMADRGISKSDLARATGISRATLSRLRKGKpkRVSLDTLDKICDALGCQPGDLLEYV 61
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 6-61 8.64e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 30.98  E-value: 8.64e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 500000237  6 ERLWELTLKRRINKTSLRDMAGITNSTLSRLSKDET-VSMEALARLCEALQCQLEEI 61
Cdd:cd00093   2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRnPSLETLEKLAKALGVSLDEL 58
 
Name Accession Description Interval E-value
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
5-69 1.54e-16

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 66.32  E-value: 1.54e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500000237  5 YERLWELTLKRRINKTSLRDMAGITNSTLSRLSKDET--VSMEALARLCEALQCQLEEIIEYKLENK 69
Cdd:COG3655   3 YVKLDELLAERGMTKKELAEATGISRATLSRLKNGKAkaVRLDTLEKICKALDCQPGDLLEYVPDEE 69
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 7-65 7.57e-14

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 59.48  E-value: 7.57e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 500000237   7 RLWELTLKRRINKTSLRDMAGITNSTLSRLSKDE--TVSMEALARLCEALQCQLEEIIEYK 65
Cdd:pfam13443  1 KLRKLMADRGISKSDLARATGISRATLSRLRKGKpkRVSLDTLDKICDALGCQPGDLLEYV 61
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
15-73 6.20e-03

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 31.89  E-value: 6.20e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500000237 15 RRINKTSLRDMA---GITNSTLSRLSKDET-VSMEALARLCEALQCQLEEIIEYKLENKDRVE 73
Cdd:COG1396  16 RKARGLTQEELAerlGVSRSTISRIERGRRnPSLETLLKLAKALGVSLDELLGGADEELPEAL 78
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 6-61 8.64e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 30.98  E-value: 8.64e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 500000237  6 ERLWELTLKRRINKTSLRDMAGITNSTLSRLSKDET-VSMEALARLCEALQCQLEEI 61
Cdd:cd00093   2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRnPSLETLEKLAKALGVSLDEL 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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