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Conserved domains on  [gi|500020852|ref|WP_011701570|]
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GntR family transcriptional regulator [Listeria welshimeri]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-132 5.62e-22

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 89.60  E-value: 5.62e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500020852   1 MTIKRKETRESV---CYREIKKKIRNGELKPGDRLIENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFVKDsiIN 77
Cdd:COG1802    1 MTSPSPLRRESLaeqVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP--LS 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 500020852  78 KERYFEMTEII----GLFLKQAIQKIRTKKISfntvRVLAKLEEVERESEQTNPAIYFE 132
Cdd:COG1802   79 PEEIRELYEVRaaleGLAARLAAERATPADLA----RLRALLEELEAAAAAGDVAAYLE 133
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-132 5.62e-22

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 89.60  E-value: 5.62e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500020852   1 MTIKRKETRESV---CYREIKKKIRNGELKPGDRLIENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFVKDsiIN 77
Cdd:COG1802    1 MTSPSPLRRESLaeqVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP--LS 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 500020852  78 KERYFEMTEII----GLFLKQAIQKIRTKKISfntvRVLAKLEEVERESEQTNPAIYFE 132
Cdd:COG1802   79 PEEIRELYEVRaaleGLAARLAAERATPADLA----RLRALLEELEAAAAAGDVAAYLE 133
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 14-72 3.57e-18

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 75.18  E-value: 3.57e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 500020852  14 YREIKKKIRNGELKPGDRL-IENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFVK 72
Cdd:cd07377    7 ADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 14-71 1.68e-14

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 65.33  E-value: 1.68e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 500020852   14 YREIKKKIRNGELKPGDRLI-ENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFV 71
Cdd:pfam00392   6 YARLREDILSGRLRPGDKLPsERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
14-71 1.15e-13

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 63.36  E-value: 1.15e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 500020852    14 YREIKKKIRNGELKPGDRLI-ENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFV 71
Cdd:smart00345   2 AERLREDIVSGELRPGDKLPsERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK09764 PRK09764
GntR family transcriptional regulator;
14-81 9.74e-06

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 44.82  E-value: 9.74e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500020852  14 YREI----KKKIRNGELKPGDRL-IENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFVKDSIINKERY 81
Cdd:PRK09764   7 YRQIadriREQIARGELKPGDALpTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIF 79
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-132 5.62e-22

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 89.60  E-value: 5.62e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500020852   1 MTIKRKETRESV---CYREIKKKIRNGELKPGDRLIENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFVKDsiIN 77
Cdd:COG1802    1 MTSPSPLRRESLaeqVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP--LS 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 500020852  78 KERYFEMTEII----GLFLKQAIQKIRTKKISfntvRVLAKLEEVERESEQTNPAIYFE 132
Cdd:COG1802   79 PEEIRELYEVRaaleGLAARLAAERATPADLA----RLRALLEELEAAAAAGDVAAYLE 133
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 14-72 3.57e-18

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 75.18  E-value: 3.57e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 500020852  14 YREIKKKIRNGELKPGDRL-IENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFVK 72
Cdd:cd07377    7 ADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 14-71 1.68e-14

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 65.33  E-value: 1.68e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 500020852   14 YREIKKKIRNGELKPGDRLI-ENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFV 71
Cdd:pfam00392   6 YARLREDILSGRLRPGDKLPsERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
14-71 1.15e-13

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 63.36  E-value: 1.15e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 500020852    14 YREIKKKIRNGELKPGDRLI-ENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFV 71
Cdd:smart00345   2 AERLREDIVSGELRPGDKLPsERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
14-110 1.99e-13

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 66.81  E-value: 1.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500020852  14 YREIKKKIRNGELKPGDRL-IENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFVKDSIINK--ERYFEMTEIIgl 90
Cdd:COG2188   11 ADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYplSRLTSFTEEL-- 88

                         90       100
                 ....*....|....*....|
gi 500020852  91 flKQAIQKIRTKKISFNTVR 110
Cdd:COG2188   89 --RARGREPSTRVLSAERVP 106
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
1-62 2.14e-12

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 63.80  E-value: 2.14e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500020852   1 MTIKRKETRESVcYREIKKKIRNGELKPGDRL-IENTLSKQLEISRTPIRKAIGMLAADGYVE 62
Cdd:COG2186    1 KPIRRRSLAEQV-AEQLRELILSGELKPGDRLpSERELAEQLGVSRTTVREALRALEALGLVE 62
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 14-62 2.55e-07

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 50.21  E-value: 2.55e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 500020852  14 YREIKKKIRNGELKPGDRL-IENTLSKQLEISRTPIRKAIGMLAADGYVE 62
Cdd:COG1167   18 ADALREAILSGRLPPGDRLpSSRELAAQLGVSRSTVVRAYEELEAEGLIE 67
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
14-97 4.56e-07

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 46.71  E-value: 4.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500020852  14 YREIKKKIRNGELKPGDRL--IeNTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFVKD---SIINKERYFEMTEII 88
Cdd:COG1725   16 ADQIKEAIASGELKPGDRLpsV-RELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEdarELLEERREEFLEEAL 94


                 ....*....
gi 500020852  89 GLFLKQAIQ 97
Cdd:COG1725   95 RELVAEARR 103
PRK09764 PRK09764
GntR family transcriptional regulator;
14-81 9.74e-06

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 44.82  E-value: 9.74e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500020852  14 YREI----KKKIRNGELKPGDRL-IENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFVKDSIINKERY 81
Cdd:PRK09764   7 YRQIadriREQIARGELKPGDALpTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIF 79
PRK11523 PRK11523
transcriptional regulator ExuR;
16-124 1.01e-05

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 44.84  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500020852  16 EIKKKIRNGELKPGDRL-IENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFVkdsIINKERYFEMTE------II 88
Cdd:PRK11523  16 ELKERIEQGVYLVGDKLpAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHV---VSNQPRHQQAADnnmefaNY 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 500020852  89 GLF-LKQAIQKIRTKKISFNTVRV----LAKLEEVERESEQ 124
Cdd:PRK11523  93 GPFeLLQARQLIESNIAEFAATQVtkqdIMKLMAIQEQARG 133
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
16-75 5.76e-05

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 42.70  E-value: 5.76e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 500020852  16 EIKKKIRNGELKPGDRLI-ENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFVKDSI 75
Cdd:PRK09464  18 QLEFLILEGTLRPGEKLPpERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSL 78
PRK10225 PRK10225
Uxu operon transcriptional regulator;
14-79 1.67e-04

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 41.54  E-value: 1.67e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 500020852  14 YREIKKKIRN----GELKPGDRLI-ENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFVKDSIINKE 79
Cdd:PRK10225  11 YQEVGAMIRDliikTPYNPGERLPpEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHN 81
PRK11414 PRK11414
GntR family transcriptional regulator;
15-52 2.17e-04

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 41.01  E-value: 2.17e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 500020852  15 REIKKKIRNGELKPGDRLIENTLSKQLEISRTPIRKAI 52
Cdd:PRK11414  18 NDLKHQLSIGALKPGARLITKNLAEQLGMSITPVREAL 55
PRK11402 PRK11402
transcriptional regulator PhoB;
17-72 7.16e-04

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 39.43  E-value: 7.16e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 500020852  17 IKKKIRNGELKPGDRL-IENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFVK 72
Cdd:PRK11402  18 LLDDIAQGVYQAGQQIpTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQ 74
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 21-72 7.47e-04

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 39.37  E-value: 7.47e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 500020852  21 IRNGELKPGDRL-IENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFVK 72
Cdd:PRK10421  15 IEEKNLEAGMKLpAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIR 67
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 4-73 3.11e-03

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 37.44  E-value: 3.11e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 500020852   4 KRKETRESVCYReIKKKIRNGELKPGDRL-IENTLSKQLEISRTPIRKAIGMLAADGYVEYNDFRGAFVKD 73
Cdd:PRK09990   4 ERRPIADVVAER-IERLIVDGVLKVGQALpSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVAR 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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