NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|501083054|ref|WP_012133593|]
View 

exonuclease subunit SbcC [Citrobacter koseri]

Protein Classification

exonuclease subunit SbcC( domain architecture ID 11484627)

exonuclease subunit SbcC, together with SbcD, forms SbcCD complex that cleaves DNA hairpin structures

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
1-1047 0e+00

exonuclease subunit SbcC; Provisional


:

Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 1671.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    1 MKILSLRLKNLNSLKGEWKVDFTAEPFASNGLFAITGPTGAGKTTLLDAICLALYHETPRLSTVSQSQNDLMTRDTAECL 80
Cdd:PRK10246    1 MKILSLRLKNLNSLKGEWKIDFTAEPFASNGLFAITGPTGAGKTTLLDAICLALYHETPRLNNVSQSQNDLMTRDTAECL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   81 AEVEFEVKGESYRAFWSQNRARNQPDGNLQVPRVELARCADGKILADKVKDKLEMTASLTGLDYGRFTRSMLLSQGQFAA 160
Cdd:PRK10246   81 AEVEFEVKGEAYRAFWSQNRARNQPDGNLQAPRVELARCADGKILADKVKDKLELTATLTGLDYGRFTRSMLLSQGQFAA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  161 FLNAKPKERAELLEELTGTEIYGQISALVFEKHKTARTDLEKLQAQASGVSLLAPEQQHSLNESLQALTDEEKQLLARQQ 240
Cdd:PRK10246  161 FLNAKPKERAELLEELTGTEIYGQISAMVFEQHKSARTELEKLQAQASGVALLTPEQVQSLTASLQVLTDEEKQLLTAQQ 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  241 LHQQHLHWLTRQNELQAEMNRRQQALRVSQEEQENAQPQLAALNLAHPARQLRPHWERIEEQTAAAGRTRQQIQEVNARL 320
Cdd:PRK10246  241 QQQQSLNWLTRLDELQQEASRRQQALQQALAAEEKAQPQLAALSLAQPARQLRPHWERIQEQSAALAHTRQQIEEVNTRL 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  321 QSVLHLRSRIRHSAQQQSAELRATMQTLTGWLTEHERFRLWSSELAGWRALFAQQSSDKVQLLKWQQQCASDIRKRDALP 400
Cdd:PRK10246  321 QSTMALRARIRHHAAKQSAELQAQQQSLNTWLAEHDRFRQWNNELAGWRAQFSQQTSDREQLRQWQQQLTHAEQKLNALP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  401 PNPLTLTPEEATAALAQHTQQQPLRQRLASLHGQIAPKQKRREQLQTAIQNSQQELARRSAALEGKRQKYKEKNQQFMDV 480
Cdd:PRK10246  401 AITLTLTADEVAAALAQHAEQRPLRQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEKTQQLADV 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  481 KTICEQEARIKDLESQRALLQSGQPCPLCGSTSHPAIASYQALEPGVNQARRDALEKEVKTLAEEGAALRGQLETLTQQL 560
Cdd:PRK10246  481 KTICEQEARIKDLEAQRAQLQAGQPCPLCGSTSHPAVEAYQALEPGVNQSRLDALEKEVKKLGEEGAALRGQLDALTKQL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  561 HRDESEVQALVKEEQALTQEWQTLCDALNVTLHPQDDISPWLTARQDYEQQLYQLSQRHMLQAQIAAHTGQVTQFQQQID 640
Cdd:PRK10246  561 QRDESEAQSLRQEEQALTQQWQAVCASLNITLQPQDDIQPWLDAQEEHERQLRLLSQRHELQGQIAAHNQQIIQYQQQIE 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  641 QRQTTLLSELRRYGLSLPADGEEASWLNARADDAQTWQQRQTELGELQTRIAQLTPLLETLPETDILPESDERVALDNWR 720
Cdd:PRK10246  641 QRQQQLLTALAGYALTLPQEDEEASWLATRQQEAQSWQQRQNELTALQNRIQQLTPLLETLPQSDDLPHSEETVALDNWR 720
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  721 QVHDDCVSLQSQWQTLQQQEAQEMQRVAQAQAHFDAALKASVFDDRAAFLAALLDDETIARLEQHRQALENQLQQAQALA 800
Cdd:PRK10246  721 QVHEQCLSLHSQLQTLQQQDVLEAQRLQKAQAQFDTALQASVFDDQQAFLAALLDEETLTQLEQLKQNLENQRQQAQTLV 800
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  801 AQANQALAEHQQHPPEGLDLTLTPEHIQQAVAQLTGQLRDNTTRQGEIRQQLKQDANNRQQQQSLMLEIENASQQVEDWG 880
Cdd:PRK10246  801 TQTAQALAQHQQHRPDGLDLTVTVEQIQQELAQLAQQLRENTTRQGEIRQQLKQDADNRQQQQALMQQIAQATQQVEDWG 880
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  881 YLNALIGSKEGDKFRKFAQGLTLDNLVWLANNQLTRLHGRYLLQRKASEALELEVVDTWQADAVRDTRTLSGGESFLVSL 960
Cdd:PRK10246  881 YLNSLIGSKEGDKFRKFAQGLTLDNLVWLANQQLTRLHGRYLLQRKASEALELEVVDTWQADAVRDTRTLSGGESFLVSL 960
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  961 ALALALSDLVSHKTRIDSLFLDEGFGTLDSETLDTALDALDALNATGKTIGVISHVEAMKERIPVQIKVKKINGLGYSKL 1040
Cdd:PRK10246  961 ALALALSDLVSHKTRIDSLFLDEGFGTLDSETLDTALDALDALNASGKTIGVISHVEAMKERIPVQIKVKKINGLGYSKL 1040

                  ....*..
gi 501083054 1041 DKMFAVE 1047
Cdd:PRK10246 1041 DSAFAVK 1047
 
Name Accession Description Interval E-value
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
1-1047 0e+00

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 1671.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    1 MKILSLRLKNLNSLKGEWKVDFTAEPFASNGLFAITGPTGAGKTTLLDAICLALYHETPRLSTVSQSQNDLMTRDTAECL 80
Cdd:PRK10246    1 MKILSLRLKNLNSLKGEWKIDFTAEPFASNGLFAITGPTGAGKTTLLDAICLALYHETPRLNNVSQSQNDLMTRDTAECL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   81 AEVEFEVKGESYRAFWSQNRARNQPDGNLQVPRVELARCADGKILADKVKDKLEMTASLTGLDYGRFTRSMLLSQGQFAA 160
Cdd:PRK10246   81 AEVEFEVKGEAYRAFWSQNRARNQPDGNLQAPRVELARCADGKILADKVKDKLELTATLTGLDYGRFTRSMLLSQGQFAA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  161 FLNAKPKERAELLEELTGTEIYGQISALVFEKHKTARTDLEKLQAQASGVSLLAPEQQHSLNESLQALTDEEKQLLARQQ 240
Cdd:PRK10246  161 FLNAKPKERAELLEELTGTEIYGQISAMVFEQHKSARTELEKLQAQASGVALLTPEQVQSLTASLQVLTDEEKQLLTAQQ 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  241 LHQQHLHWLTRQNELQAEMNRRQQALRVSQEEQENAQPQLAALNLAHPARQLRPHWERIEEQTAAAGRTRQQIQEVNARL 320
Cdd:PRK10246  241 QQQQSLNWLTRLDELQQEASRRQQALQQALAAEEKAQPQLAALSLAQPARQLRPHWERIQEQSAALAHTRQQIEEVNTRL 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  321 QSVLHLRSRIRHSAQQQSAELRATMQTLTGWLTEHERFRLWSSELAGWRALFAQQSSDKVQLLKWQQQCASDIRKRDALP 400
Cdd:PRK10246  321 QSTMALRARIRHHAAKQSAELQAQQQSLNTWLAEHDRFRQWNNELAGWRAQFSQQTSDREQLRQWQQQLTHAEQKLNALP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  401 PNPLTLTPEEATAALAQHTQQQPLRQRLASLHGQIAPKQKRREQLQTAIQNSQQELARRSAALEGKRQKYKEKNQQFMDV 480
Cdd:PRK10246  401 AITLTLTADEVAAALAQHAEQRPLRQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEKTQQLADV 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  481 KTICEQEARIKDLESQRALLQSGQPCPLCGSTSHPAIASYQALEPGVNQARRDALEKEVKTLAEEGAALRGQLETLTQQL 560
Cdd:PRK10246  481 KTICEQEARIKDLEAQRAQLQAGQPCPLCGSTSHPAVEAYQALEPGVNQSRLDALEKEVKKLGEEGAALRGQLDALTKQL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  561 HRDESEVQALVKEEQALTQEWQTLCDALNVTLHPQDDISPWLTARQDYEQQLYQLSQRHMLQAQIAAHTGQVTQFQQQID 640
Cdd:PRK10246  561 QRDESEAQSLRQEEQALTQQWQAVCASLNITLQPQDDIQPWLDAQEEHERQLRLLSQRHELQGQIAAHNQQIIQYQQQIE 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  641 QRQTTLLSELRRYGLSLPADGEEASWLNARADDAQTWQQRQTELGELQTRIAQLTPLLETLPETDILPESDERVALDNWR 720
Cdd:PRK10246  641 QRQQQLLTALAGYALTLPQEDEEASWLATRQQEAQSWQQRQNELTALQNRIQQLTPLLETLPQSDDLPHSEETVALDNWR 720
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  721 QVHDDCVSLQSQWQTLQQQEAQEMQRVAQAQAHFDAALKASVFDDRAAFLAALLDDETIARLEQHRQALENQLQQAQALA 800
Cdd:PRK10246  721 QVHEQCLSLHSQLQTLQQQDVLEAQRLQKAQAQFDTALQASVFDDQQAFLAALLDEETLTQLEQLKQNLENQRQQAQTLV 800
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  801 AQANQALAEHQQHPPEGLDLTLTPEHIQQAVAQLTGQLRDNTTRQGEIRQQLKQDANNRQQQQSLMLEIENASQQVEDWG 880
Cdd:PRK10246  801 TQTAQALAQHQQHRPDGLDLTVTVEQIQQELAQLAQQLRENTTRQGEIRQQLKQDADNRQQQQALMQQIAQATQQVEDWG 880
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  881 YLNALIGSKEGDKFRKFAQGLTLDNLVWLANNQLTRLHGRYLLQRKASEALELEVVDTWQADAVRDTRTLSGGESFLVSL 960
Cdd:PRK10246  881 YLNSLIGSKEGDKFRKFAQGLTLDNLVWLANQQLTRLHGRYLLQRKASEALELEVVDTWQADAVRDTRTLSGGESFLVSL 960
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  961 ALALALSDLVSHKTRIDSLFLDEGFGTLDSETLDTALDALDALNATGKTIGVISHVEAMKERIPVQIKVKKINGLGYSKL 1040
Cdd:PRK10246  961 ALALALSDLVSHKTRIDSLFLDEGFGTLDSETLDTALDALDALNASGKTIGVISHVEAMKERIPVQIKVKKINGLGYSKL 1040

                  ....*..
gi 501083054 1041 DKMFAVE 1047
Cdd:PRK10246 1041 DSAFAVK 1047
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1-1039 0e+00

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 775.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054     1 MKILSLRLKNLNSLKGEWKVDFTAEPfasnGLFAITGPTGAGKTTLLDAICLALYHETPRLSTVSQSQNDLMTRDTAECL 80
Cdd:TIGR00618    1 MKPLRLTLKNFGSYKGTHTIDFTALG----PIFLICGKTGAGKTTLLDAITYALYGKLPRRSEVIRSLNSLYAAPSEAAF 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    81 AEVEFEVKGESYRAFWSQNRARNQPDGNLQVPRVELARCADGKILADKVKDKLEMTASLTGLDYGRFTRSMLLSQGQFAA 160
Cdd:TIGR00618   77 AELEFSLGTKIYRVHRTLRCTRSHRKTEQPEQLYLEQKKGRGRILAAKKSETEEVIHDLLKLDYKTFTRVVLLPQGEFAQ 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   161 FLNAKPKERAELLEELTGTEIYGQISALVFEKHKTARTDLEKLQAQASGVSLLAPEQQHSLNESLQALTDEEKQLLARQQ 240
Cdd:TIGR00618  157 FLKAKSKEKKELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQ 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   241 LHQQHLHWLTRQNELQAEMNRRQQALRVSQEEQENAQPQLAALNLAHPARQLRPHWERIEEQTAAAGRTRQQIQEVNARL 320
Cdd:TIGR00618  237 QTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTEL 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   321 QSVLHLRSRIRH---SAQQQSAELRATMQTLTGWLTEHERFRLWSSELAGWRALFAQQSSDKVQLLKWQQQCASDIRKRD 397
Cdd:TIGR00618  317 QSKMRSRAKLLMkraAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQ 396
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   398 ALPPNPLTLTPEEATAAlAQHTQQQPLRQRLASLHGQIAPKQKRREQLQTAIQNSQQELARRSAALEGKRQKYKEKNQQF 477
Cdd:TIGR00618  397 SLCKELDILQREQATID-TRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQL 475
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   478 MDVKTICEQEARIKDLESQRALLQSGQPCPLCGSTSHPAIASYQALEPGVNQARRDALEKEVKTLAEEGAALRGQLETLT 557
Cdd:TIGR00618  476 QTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSER 555
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   558 QQLHRDESEVQALVKEEQALTQEWQTLCDALNVTLHPQDDISPWLTARQDYEQQLYQLSQRHMLQAQIAAHTGQVTQFQQ 637
Cdd:TIGR00618  556 KQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQ 635
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   638 QIDQRQTTLLSELRRYGLSLPADGEEASWLNARADDAQTWQQRQTELGELQTRIAQLTPLLETLPETDILPESDERVALD 717
Cdd:TIGR00618  636 QCSQELALKLTALHALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEE 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   718 NWRQVHDDCVSLQSQWQTLQQQEAQEMQRVAQAQAHFDAALKASVFDDRAAFLAALLDDETIARLEQHRQALENQLQQAQ 797
Cdd:TIGR00618  716 YDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLRE 795
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   798 ALAAQANQALAEHQQHPPEGLD-LTLTPEHIQQAVAQLTGQLRDNTTRQGEIRQQLKQDANNRQQQQSLMLEIENASQQV 876
Cdd:TIGR00618  796 EDTHLLKTLEAEIGQEIPSDEDiLNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLS 875
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   877 EDWGYLNALIGSKEGDKFRKFAQGLTLDNLVWLANNQLTRLHGRYLLQRKAS--EALELEVVDTWQADAVRDTRTLSGGE 954
Cdd:TIGR00618  876 DKLNGINQIKIQFDGDALIKFLHEITLYANVRLANQSEGRFHGRYADSHVNArkYQGLALLVADAYTGSVRPSATLSGGE 955
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   955 SFLVSLALA--LALSDLVSHKTRIDSLFLDEGFGTLDSETLDTALDALDALNATGKTIGVISHVEAMKERIPVQIKVKKI 1032
Cdd:TIGR00618  956 TFLASLSLAlaLADLLSTSGGTVLDSLFIDEGFGSLDEDSLDRAIGILDAIREGSKMIGIISHVPEFRERIPHRILVKKT 1035

                   ....*..
gi 501083054  1033 NGLGYSK 1039
Cdd:TIGR00618 1036 NAGSHVM 1042
SbcC COG0419
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
2-205 3.21e-30

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];


Pssm-ID: 440188 [Multi-domain]  Cd Length: 204  Bit Score: 118.96  E-value: 3.21e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    2 KILSLRLKNLNSLKGEWKVDFTAepfasnGLFAITGPTGAGKTTLLDAICLALYHETprlSTVSQSQNDLMTRDTAECLA 81
Cdd:COG0419     1 KLLRLRLENFRSYRDTETIDFDD------GLNLIVGPNGAGKSTILEAIRYALYGKA---RSRSKLRSDLINVGSEEASV 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   82 EVEFEVKGESYRAFWsqnrarnqpdgnlqvprvelarcadgkiladkvkdklemtasltgldygrftrsmllSQGQFAAF 161
Cdd:COG0419    72 ELEFEHGGKRYRIER---------------------------------------------------------RQGEFAEF 94
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 501083054  162 LNAKPKERAELLEELTGTEIYGQISALVFEKHKTARTDLEKLQA 205
Cdd:COG0419    95 LEAKPSERKEALKRLLGLEIYEELKERLKELEEALESALEELAE 138
ABC_sbcCD cd03279
ATP-binding cassette domain of sbcCD; SbcCD and other Mre11/Rad50 (MR) complexes are ...
1-162 2.35e-27

ATP-binding cassette domain of sbcCD; SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini.


Pssm-ID: 213246 [Multi-domain]  Cd Length: 213  Bit Score: 110.82  E-value: 2.35e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    1 MKILSLRLKNLNSLKGEWKVDFTaePFASNGLFAITGPTGAGKTTLLDAICLALYHETPRLstvSQSQNDLMTRDTAECL 80
Cdd:cd03279     1 MKPLKLELKNFGPFREEQVIDFT--GLDNNGLFLICGPTGAGKSTILDAITYALYGKTPRY---GRQENLRSVFAPGEDT 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   81 AEV--EFEVKGESYRAFwsqnRARnqpdgnlqvprvelarcadgkiladkvkdklemtasltGLDYGRFTRSMLLSQGQF 158
Cdd:cd03279    76 AEVsfTFQLGGKKYRVE----RSR--------------------------------------GLDYDQFTRIVLLPQGEF 113

                  ....
gi 501083054  159 AAFL 162
Cdd:cd03279   114 DRFL 117
AAA_23 pfam13476
AAA domain;
6-206 5.98e-21

AAA domain;


Pssm-ID: 463890 [Multi-domain]  Cd Length: 190  Bit Score: 91.79  E-value: 5.98e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054     6 LRLKNLNSLKgEWKVDFtaepfaSNGLFAITGPTGAGKTTLLDAICLALYHETPRLSTVSQSQN-----DLMTRDTAECL 80
Cdd:pfam13476    1 LTIENFRSFR-DQTIDF------SKGLTLITGPNGSGKTTILDAIKLALYGKTSRLKRKSGGGFvkgdiRIGLEGKGKAY 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    81 AEVEFEVKGE--SYRAFWSQNRARNQPDGNLQVPRVELARCADGKILADKVKDKLEmtasltgldygRFTRSMLLSQGQF 158
Cdd:pfam13476   74 VEITFENNDGryTYAIERSRELSKKKGKTKKKEILEILEIDELQQFISELLKSDKI-----------ILPLLVFLGQERE 142
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 501083054   159 AAFLNAKPKERAELLEELTGTEIYGQISALVFEKHKTARTDLEKLQAQ 206
Cdd:pfam13476  143 EEFERKEKKERLEELEKALEEKEDEKKLLEKLLQLKEKKKELEELKEE 190
 
Name Accession Description Interval E-value
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
1-1047 0e+00

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 1671.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    1 MKILSLRLKNLNSLKGEWKVDFTAEPFASNGLFAITGPTGAGKTTLLDAICLALYHETPRLSTVSQSQNDLMTRDTAECL 80
Cdd:PRK10246    1 MKILSLRLKNLNSLKGEWKIDFTAEPFASNGLFAITGPTGAGKTTLLDAICLALYHETPRLNNVSQSQNDLMTRDTAECL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   81 AEVEFEVKGESYRAFWSQNRARNQPDGNLQVPRVELARCADGKILADKVKDKLEMTASLTGLDYGRFTRSMLLSQGQFAA 160
Cdd:PRK10246   81 AEVEFEVKGEAYRAFWSQNRARNQPDGNLQAPRVELARCADGKILADKVKDKLELTATLTGLDYGRFTRSMLLSQGQFAA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  161 FLNAKPKERAELLEELTGTEIYGQISALVFEKHKTARTDLEKLQAQASGVSLLAPEQQHSLNESLQALTDEEKQLLARQQ 240
Cdd:PRK10246  161 FLNAKPKERAELLEELTGTEIYGQISAMVFEQHKSARTELEKLQAQASGVALLTPEQVQSLTASLQVLTDEEKQLLTAQQ 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  241 LHQQHLHWLTRQNELQAEMNRRQQALRVSQEEQENAQPQLAALNLAHPARQLRPHWERIEEQTAAAGRTRQQIQEVNARL 320
Cdd:PRK10246  241 QQQQSLNWLTRLDELQQEASRRQQALQQALAAEEKAQPQLAALSLAQPARQLRPHWERIQEQSAALAHTRQQIEEVNTRL 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  321 QSVLHLRSRIRHSAQQQSAELRATMQTLTGWLTEHERFRLWSSELAGWRALFAQQSSDKVQLLKWQQQCASDIRKRDALP 400
Cdd:PRK10246  321 QSTMALRARIRHHAAKQSAELQAQQQSLNTWLAEHDRFRQWNNELAGWRAQFSQQTSDREQLRQWQQQLTHAEQKLNALP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  401 PNPLTLTPEEATAALAQHTQQQPLRQRLASLHGQIAPKQKRREQLQTAIQNSQQELARRSAALEGKRQKYKEKNQQFMDV 480
Cdd:PRK10246  401 AITLTLTADEVAAALAQHAEQRPLRQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEKTQQLADV 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  481 KTICEQEARIKDLESQRALLQSGQPCPLCGSTSHPAIASYQALEPGVNQARRDALEKEVKTLAEEGAALRGQLETLTQQL 560
Cdd:PRK10246  481 KTICEQEARIKDLEAQRAQLQAGQPCPLCGSTSHPAVEAYQALEPGVNQSRLDALEKEVKKLGEEGAALRGQLDALTKQL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  561 HRDESEVQALVKEEQALTQEWQTLCDALNVTLHPQDDISPWLTARQDYEQQLYQLSQRHMLQAQIAAHTGQVTQFQQQID 640
Cdd:PRK10246  561 QRDESEAQSLRQEEQALTQQWQAVCASLNITLQPQDDIQPWLDAQEEHERQLRLLSQRHELQGQIAAHNQQIIQYQQQIE 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  641 QRQTTLLSELRRYGLSLPADGEEASWLNARADDAQTWQQRQTELGELQTRIAQLTPLLETLPETDILPESDERVALDNWR 720
Cdd:PRK10246  641 QRQQQLLTALAGYALTLPQEDEEASWLATRQQEAQSWQQRQNELTALQNRIQQLTPLLETLPQSDDLPHSEETVALDNWR 720
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  721 QVHDDCVSLQSQWQTLQQQEAQEMQRVAQAQAHFDAALKASVFDDRAAFLAALLDDETIARLEQHRQALENQLQQAQALA 800
Cdd:PRK10246  721 QVHEQCLSLHSQLQTLQQQDVLEAQRLQKAQAQFDTALQASVFDDQQAFLAALLDEETLTQLEQLKQNLENQRQQAQTLV 800
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  801 AQANQALAEHQQHPPEGLDLTLTPEHIQQAVAQLTGQLRDNTTRQGEIRQQLKQDANNRQQQQSLMLEIENASQQVEDWG 880
Cdd:PRK10246  801 TQTAQALAQHQQHRPDGLDLTVTVEQIQQELAQLAQQLRENTTRQGEIRQQLKQDADNRQQQQALMQQIAQATQQVEDWG 880
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  881 YLNALIGSKEGDKFRKFAQGLTLDNLVWLANNQLTRLHGRYLLQRKASEALELEVVDTWQADAVRDTRTLSGGESFLVSL 960
Cdd:PRK10246  881 YLNSLIGSKEGDKFRKFAQGLTLDNLVWLANQQLTRLHGRYLLQRKASEALELEVVDTWQADAVRDTRTLSGGESFLVSL 960
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  961 ALALALSDLVSHKTRIDSLFLDEGFGTLDSETLDTALDALDALNATGKTIGVISHVEAMKERIPVQIKVKKINGLGYSKL 1040
Cdd:PRK10246  961 ALALALSDLVSHKTRIDSLFLDEGFGTLDSETLDTALDALDALNASGKTIGVISHVEAMKERIPVQIKVKKINGLGYSKL 1040

                  ....*..
gi 501083054 1041 DKMFAVE 1047
Cdd:PRK10246 1041 DSAFAVK 1047
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1-1039 0e+00

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 775.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054     1 MKILSLRLKNLNSLKGEWKVDFTAEPfasnGLFAITGPTGAGKTTLLDAICLALYHETPRLSTVSQSQNDLMTRDTAECL 80
Cdd:TIGR00618    1 MKPLRLTLKNFGSYKGTHTIDFTALG----PIFLICGKTGAGKTTLLDAITYALYGKLPRRSEVIRSLNSLYAAPSEAAF 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    81 AEVEFEVKGESYRAFWSQNRARNQPDGNLQVPRVELARCADGKILADKVKDKLEMTASLTGLDYGRFTRSMLLSQGQFAA 160
Cdd:TIGR00618   77 AELEFSLGTKIYRVHRTLRCTRSHRKTEQPEQLYLEQKKGRGRILAAKKSETEEVIHDLLKLDYKTFTRVVLLPQGEFAQ 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   161 FLNAKPKERAELLEELTGTEIYGQISALVFEKHKTARTDLEKLQAQASGVSLLAPEQQHSLNESLQALTDEEKQLLARQQ 240
Cdd:TIGR00618  157 FLKAKSKEKKELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQ 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   241 LHQQHLHWLTRQNELQAEMNRRQQALRVSQEEQENAQPQLAALNLAHPARQLRPHWERIEEQTAAAGRTRQQIQEVNARL 320
Cdd:TIGR00618  237 QTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTEL 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   321 QSVLHLRSRIRH---SAQQQSAELRATMQTLTGWLTEHERFRLWSSELAGWRALFAQQSSDKVQLLKWQQQCASDIRKRD 397
Cdd:TIGR00618  317 QSKMRSRAKLLMkraAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQ 396
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   398 ALPPNPLTLTPEEATAAlAQHTQQQPLRQRLASLHGQIAPKQKRREQLQTAIQNSQQELARRSAALEGKRQKYKEKNQQF 477
Cdd:TIGR00618  397 SLCKELDILQREQATID-TRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQL 475
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   478 MDVKTICEQEARIKDLESQRALLQSGQPCPLCGSTSHPAIASYQALEPGVNQARRDALEKEVKTLAEEGAALRGQLETLT 557
Cdd:TIGR00618  476 QTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSER 555
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   558 QQLHRDESEVQALVKEEQALTQEWQTLCDALNVTLHPQDDISPWLTARQDYEQQLYQLSQRHMLQAQIAAHTGQVTQFQQ 637
Cdd:TIGR00618  556 KQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQ 635
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   638 QIDQRQTTLLSELRRYGLSLPADGEEASWLNARADDAQTWQQRQTELGELQTRIAQLTPLLETLPETDILPESDERVALD 717
Cdd:TIGR00618  636 QCSQELALKLTALHALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEE 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   718 NWRQVHDDCVSLQSQWQTLQQQEAQEMQRVAQAQAHFDAALKASVFDDRAAFLAALLDDETIARLEQHRQALENQLQQAQ 797
Cdd:TIGR00618  716 YDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLRE 795
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   798 ALAAQANQALAEHQQHPPEGLD-LTLTPEHIQQAVAQLTGQLRDNTTRQGEIRQQLKQDANNRQQQQSLMLEIENASQQV 876
Cdd:TIGR00618  796 EDTHLLKTLEAEIGQEIPSDEDiLNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLS 875
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   877 EDWGYLNALIGSKEGDKFRKFAQGLTLDNLVWLANNQLTRLHGRYLLQRKAS--EALELEVVDTWQADAVRDTRTLSGGE 954
Cdd:TIGR00618  876 DKLNGINQIKIQFDGDALIKFLHEITLYANVRLANQSEGRFHGRYADSHVNArkYQGLALLVADAYTGSVRPSATLSGGE 955
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   955 SFLVSLALA--LALSDLVSHKTRIDSLFLDEGFGTLDSETLDTALDALDALNATGKTIGVISHVEAMKERIPVQIKVKKI 1032
Cdd:TIGR00618  956 TFLASLSLAlaLADLLSTSGGTVLDSLFIDEGFGSLDEDSLDRAIGILDAIREGSKMIGIISHVPEFRERIPHRILVKKT 1035

                   ....*..
gi 501083054  1033 NGLGYSK 1039
Cdd:TIGR00618 1036 NAGSHVM 1042
SbcC COG0419
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
2-205 3.21e-30

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];


Pssm-ID: 440188 [Multi-domain]  Cd Length: 204  Bit Score: 118.96  E-value: 3.21e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    2 KILSLRLKNLNSLKGEWKVDFTAepfasnGLFAITGPTGAGKTTLLDAICLALYHETprlSTVSQSQNDLMTRDTAECLA 81
Cdd:COG0419     1 KLLRLRLENFRSYRDTETIDFDD------GLNLIVGPNGAGKSTILEAIRYALYGKA---RSRSKLRSDLINVGSEEASV 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   82 EVEFEVKGESYRAFWsqnrarnqpdgnlqvprvelarcadgkiladkvkdklemtasltgldygrftrsmllSQGQFAAF 161
Cdd:COG0419    72 ELEFEHGGKRYRIER---------------------------------------------------------RQGEFAEF 94
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 501083054  162 LNAKPKERAELLEELTGTEIYGQISALVFEKHKTARTDLEKLQA 205
Cdd:COG0419    95 LEAKPSERKEALKRLLGLEIYEELKERLKELEEALESALEELAE 138
ABC_sbcCD cd03279
ATP-binding cassette domain of sbcCD; SbcCD and other Mre11/Rad50 (MR) complexes are ...
1-162 2.35e-27

ATP-binding cassette domain of sbcCD; SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini.


Pssm-ID: 213246 [Multi-domain]  Cd Length: 213  Bit Score: 110.82  E-value: 2.35e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    1 MKILSLRLKNLNSLKGEWKVDFTaePFASNGLFAITGPTGAGKTTLLDAICLALYHETPRLstvSQSQNDLMTRDTAECL 80
Cdd:cd03279     1 MKPLKLELKNFGPFREEQVIDFT--GLDNNGLFLICGPTGAGKSTILDAITYALYGKTPRY---GRQENLRSVFAPGEDT 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   81 AEV--EFEVKGESYRAFwsqnRARnqpdgnlqvprvelarcadgkiladkvkdklemtasltGLDYGRFTRSMLLSQGQF 158
Cdd:cd03279    76 AEVsfTFQLGGKKYRVE----RSR--------------------------------------GLDYDQFTRIVLLPQGEF 113

                  ....
gi 501083054  159 AAFL 162
Cdd:cd03279   114 DRFL 117
ABC_sbcCD cd03279
ATP-binding cassette domain of sbcCD; SbcCD and other Mre11/Rad50 (MR) complexes are ...
945-1031 1.13e-23

ATP-binding cassette domain of sbcCD; SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini.


Pssm-ID: 213246 [Multi-domain]  Cd Length: 213  Bit Score: 100.04  E-value: 1.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  945 RDTRTLSGGESFLVSLALAL--ALSDLVSHKTRIDSLFLDEGFGTLDSETLDTALDALDALNATGKTIGVISHVEAMKER 1022
Cdd:cd03279   119 RPVSTLSGGETFLASLSLALalSEVLQNRGGARLEALFIDEGFGTLDPEALEAVATALELIRTENRMVGVISHVEELKER 198

                  ....*....
gi 501083054 1023 IPVQIKVKK 1031
Cdd:cd03279   199 IPQRLEVIK 207
AAA_23 pfam13476
AAA domain;
6-206 5.98e-21

AAA domain;


Pssm-ID: 463890 [Multi-domain]  Cd Length: 190  Bit Score: 91.79  E-value: 5.98e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054     6 LRLKNLNSLKgEWKVDFtaepfaSNGLFAITGPTGAGKTTLLDAICLALYHETPRLSTVSQSQN-----DLMTRDTAECL 80
Cdd:pfam13476    1 LTIENFRSFR-DQTIDF------SKGLTLITGPNGSGKTTILDAIKLALYGKTSRLKRKSGGGFvkgdiRIGLEGKGKAY 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    81 AEVEFEVKGE--SYRAFWSQNRARNQPDGNLQVPRVELARCADGKILADKVKDKLEmtasltgldygRFTRSMLLSQGQF 158
Cdd:pfam13476   74 VEITFENNDGryTYAIERSRELSKKKGKTKKKEILEILEIDELQQFISELLKSDKI-----------ILPLLVFLGQERE 142
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 501083054   159 AAFLNAKPKERAELLEELTGTEIYGQISALVFEKHKTARTDLEKLQAQ 206
Cdd:pfam13476  143 EEFERKEKKERLEELEKALEEKEDEKKLLEKLLQLKEKKKELEELKEE 190
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
154-617 1.73e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 75.09  E-value: 1.73e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   154 SQGQFAAFLNAKPKERAELLEELTGTEIYGQISALVFEKHKTARTDLEKLQAQASGV--SLLAPEQQHSLNESLQALTDE 231
Cdd:TIGR02168  142 EQGKISEIIEAKPEERRAIFEEAAGISKYKERRKETERKLERTRENLDRLEDILNELerQLKSLERQAEKAERYKELKAE 221
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   232 EKQLlarqqlhqQHLHWLTRQNELQAEMNRRQQALRVSQEEQENAQPQLAALNlahparqlrphwERIEEQTAAAGRTRQ 311
Cdd:TIGR02168  222 LREL--------ELALLVLRLEELREELEELQEELKEAEEELEELTAELQELE------------EKLEELRLEVSELEE 281
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   312 QIQEVNARLQSVLHLRSRIRHSAQQQSAELratmqtltgwlteherfrlwsselagwRALFAQQSSDKVQLLKWQQqcas 391
Cdd:TIGR02168  282 EIEELQKELYALANEISRLEQQKQILRERL---------------------------ANLERQLEELEAQLEELES---- 330
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   392 dirKRDALppnpltltpEEATAALAQhtQQQPLRQRLASLHGQIAPKQKRREQLQTAIQNSQQEL-ARRSAALEGKRQKY 470
Cdd:TIGR02168  331 ---KLDEL---------AEELAELEE--KLEELKEELESLEAELEELEAELEELESRLEELEEQLeTLRSKVAQLELQIA 396
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   471 KEKNQqfmdvktICEQEARIKDLESQRALLQSGQPcplcgstshPAIASYQALEPGVNQARRDALEKEVKTLAEEGAALR 550
Cdd:TIGR02168  397 SLNNE-------IERLEARLERLEDRRERLQQEIE---------ELLKKLEEAELKELQAELEELEEELEELQEELERLE 460
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501083054   551 GQLETLTQQLHRDESEVQALVKEEQALTQEWQTLCDALNVTLHPQDDISPWLTARQDYEQQLYQLSQ 617
Cdd:TIGR02168  461 EALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSE 527
PRK01156 PRK01156
chromosome segregation protein; Provisional
1-556 5.31e-12

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 70.32  E-value: 5.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    1 MKILSLRLKNLNSLKgewkvdfTAEPFASNGLFAITGPTGAGKTTLLDAICLALYHETPrlstvSQSQNDLMTRDTAECL 80
Cdd:PRK01156    1 MIIKRIRLKNFLSHD-------DSEIEFDTGINIITGKNGAGKSSIVDAIRFALFTDKR-----TEKIEDMIKKGKNNLE 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   81 AEVEFEVKGESYRAFWSQNRARNQPDGNLQVPRvelarcaDGKILADKVKDKLE-MTASLTGLDYGRFTRSMLLSQGQFA 159
Cdd:PRK01156   69 VELEFRIGGHVYQIRRSIERRGKGSRREAYIKK-------DGSIIAEGFDDTTKyIEKNILGISKDVFLNSIFVGQGEMD 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  160 AFLNAKPKERAELLEELTgteiygQISALVfEKHKTARTDLEKLQAQASGVSLLAPEQQHSLNEslqaLTDEEKQLlarQ 239
Cdd:PRK01156  142 SLISGDPAQRKKILDEIL------EINSLE-RNYDKLKDVIDMLRAEISNIDYLEEKLKSSNLE----LENIKKQI---A 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  240 QLHQQHLHWLTRQNELQAEMNRRQQALRVSQEEQENAQPQLAALNlahparqlrphweRIEEQTAAAGRTRQQIQEVNAR 319
Cdd:PRK01156  208 DDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKN-------------RYESEIKTAESDLSMELEKNNY 274
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  320 LQSVLHLRSRIRHSA--------------QQQSAELRATMQTLTGWLTEHERFRLWSSELagwralfaqqSSDKVQLLKW 385
Cdd:PRK01156  275 YKELEERHMKIINDPvyknrnyindyfkyKNDIENKKQILSNIDAEINKYHAIIKKLSVL----------QKDYNDYIKK 344
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  386 QqqcasdiRKRDALppNPLTLTPEEataalaQHTQQQPLRQRLASLHGQIAPKQKRREQLQTAIqnsQQELARRSAALEG 465
Cdd:PRK01156  345 K-------SRYDDL--NNQILELEG------YEMDYNSYLKSIESLKKKIEEYSKNIERMSAFI---SEILKIQEIDPDA 406
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  466 KRQKYKEKNQQFMDVKT-ICEQEARIKDLESQR-------ALLQSGQPCPLCGST-----SHPAIASYQALEPGVNQaRR 532
Cdd:PRK01156  407 IKKELNEINVKLQDISSkVSSLNQRIRALRENLdelsrnmEMLNGQSVCPVCGTTlgeekSNHIINHYNEKKSRLEE-KI 485
                         570       580
                  ....*....|....*....|....
gi 501083054  533 DALEKEVKTLAEEGAALRGQLETL 556
Cdd:PRK01156  486 REIEIEVKDIDEKIVDLKKRKEYL 509
46 PHA02562
endonuclease subunit; Provisional
6-284 1.17e-11

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 68.50  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    6 LRLKNLNSLKGEW-KVDFTAepFASNglfAITGPTGAGKTTLLDAICLALYHETPRLSTVSQSQNDLMTRDtaeCLAEVE 84
Cdd:PHA02562    7 IRYKNILSVGNQPiEIQLDK--VKKT---LITGKNGAGKSTMLEALTFALFGKPFRDIKKGQLINSINKKD---LLVELW 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   85 FEVKGESYRAFwsqnRArnqpdgnlQVPRVELARCaDGKILADK--VKDKLEMTASLTGLDYGRFTRSMLLSQGQFAAFL 162
Cdd:PHA02562   79 FEYGEKEYYIK----RG--------IKPNVFEIYC-NGKLLDESasSKDFQKYFEQMLGMNYKSFKQIVVLGTAGYVPFM 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  163 NAKPKERAELLEELTGTEIYGQISALVFEKHKTARTDLEKLQAQASGVSllapEQ---QHSLNESLQALTDEEkqlLARQ 239
Cdd:PHA02562  146 QLSAPARRKLVEDLLDISVLSEMDKLNKDKIRELNQQIQTLDMKIDHIQ----QQiktYNKNIEEQRKKNGEN---IARK 218
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 501083054  240 QLHQQHLhwLTRQNELQAEMNRRQQALRVSQEEQENAQPQLAALN 284
Cdd:PHA02562  219 QNKYDEL--VEEAKTIKAEIEELTDELLNLVMDIEDPSAALNKLN 261
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
425-1017 6.86e-11

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 66.33  E-value: 6.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  425 RQRLASLHGQIAPKQKRREQLQTAIQNSQQELARrsaaLEGKRQKYKEKNQQFMDVKTICEQEARIKDLESQRALLQSgq 504
Cdd:COG4717    80 LKEAEEKEEEYAELQEELEELEEELEELEAELEE----LREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEE-- 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  505 pcplcgstshpAIASYQALepgvnQARRDALEKEVKTLAEEGAALRGQLETLT-QQLHRDESEVQALVKEEQALTQEWQT 583
Cdd:COG4717   154 -----------RLEELREL-----EEELEELEAELAELQEELEELLEQLSLATeEELQDLAEELEELQQRLAELEEELEE 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  584 LCDALNVTLHPQDDISPWLTARQDyEQQLYQLSQRHMLQAQIAAHTGQVTQFQQQIDQRQTTLLSELRRYGLSLPADGEE 663
Cdd:COG4717   218 AQEELEELEEELEQLENELEAAAL-EERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLARE 296
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  664 ASWLNARADDAQTWQQRQTELGELQTRIAQLTPLLETLPETDILPESDErvaLDNWRQVHDDcvslqsqwqtlqQQEAQE 743
Cdd:COG4717   297 KASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDR---IEELQELLRE------------AEELEE 361
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  744 MQRVAQAQAHFDAALKASVFDDRAAFLAALLDDETIARLEQHRQALENQLQQAQALAAQANQALAEHQqhppegldLTLT 823
Cdd:COG4717   362 ELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEE--------LEEE 433
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  824 PEHIQQAVAQLTGQLRDNTTRQGEIRQQLKQDANNRQQQQsLMLEIENASQQ----VEDWGYLNalIGSKEGDKFRKFAQ 899
Cdd:COG4717   434 LEELEEELEELEEELEELREELAELEAELEQLEEDGELAE-LLQELEELKAElrelAEEWAALK--LALELLEEAREEYR 510
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  900 GLTLDNLVWLANNQLTRL-HGRYLLQRkASEALELEVVDtwQADAVRDTRTLSGGE----------SFLVslalalalsd 968
Cdd:COG4717   511 EERLPPVLERASEYFSRLtDGRYRLIR-IDEDLSLKVDT--EDGRTRPVEELSRGTreqlylalrlALAE---------- 577
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*....
gi 501083054  969 lvSHKTRIDSLFLDEGFGTLDSETLDTALDALDALNATGKTIGVISHVE 1017
Cdd:COG4717   578 --LLAGEPLPLILDDAFVNFDDERLRAALELLAELAKGRQVIYFTCHEE 624
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
154-790 9.69e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.03  E-value: 9.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  154 SQGQFAAFLNAKPKERAELLEELTG-----------------------------TEIYGQISAL-----VFEKHKTARTD 199
Cdd:COG1196   142 GQGMIDRIIEAKPEERRAIIEEAAGiskykerkeeaerkleateenlerledilGELERQLEPLerqaeKAERYRELKEE 221
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  200 LEKLQAQASGVSL-LAPEQQHSLNESLQALTDEEKQLLARQQLHQQHLHWL-TRQNELQAEMNRRQQALRVSQEEQENAQ 277
Cdd:COG1196   222 LKELEAELLLLKLrELEAELEELEAELEELEAELEELEAELAELEAELEELrLELEELELELEEAQAEEYELLAELARLE 301
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  278 PQLAALNLAhpARQLRPHWERIEEQTAAAGRTRQQIQEVNARLQSVLHLRSRIRHSAQQQSAELRATMQTLTGwlTEHER 357
Cdd:COG1196   302 QDIARLEER--RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEA--ELAEA 377
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  358 FRLWSSELAGWRALFAQQSSDKVQLLKWQQQCASDIRKRDALppnpltltpEEATAALAQHTQQqpLRQRLASLHGQIAP 437
Cdd:COG1196   378 EEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERL---------EEELEELEEALAE--LEEEEEEEEEALEE 446
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  438 KQKRREQLQTAIQNSQQELARRSAALEGKRQKYKEKNQQFMDVKticEQEARIKDLESQRALLQSGqpcplcgstshPAI 517
Cdd:COG1196   447 AAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAA---ARLLLLLEAEADYEGFLEG-----------VKA 512
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  518 ASYQALEPGVNQARRDALEKEVKTLAEEGAALRGQLETLTQQLHRDESEVQALVKEEQALTQEWQTLcDALNVTLHPQDD 597
Cdd:COG1196   513 ALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPL-DKIRARAALAAA 591
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  598 ISPW--LTARQDYEQQLYQLSQRHMLQAQIAAHTGQVTQFQQQIDQRQTTLLSELRRyglsLPADGEEASWLNARADdaq 675
Cdd:COG1196   592 LARGaiGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLRE----VTLEGEGGSAGGSLTG--- 664
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  676 twQQRQTELGELQTRIAQLTPLLETLPETDILPESDERVALDNWRQVHDdcvsLQSQWQTLQQQEAQEMQRVAQAQAHFD 755
Cdd:COG1196   665 --GSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAE----AEEERLEEELEEEALEEQLEAEREELL 738
                         650       660       670
                  ....*....|....*....|....*....|....*
gi 501083054  756 AALKASVFDDRAAFLAALLDDETIARLEQHRQALE 790
Cdd:COG1196   739 EELLEEEELLEEEALEELPEPPDLEELERELERLE 773
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1-569 4.47e-09

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 60.82  E-value: 4.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    1 MKILSLRLKNLNSLKgewKVDFTAEPfasnGLFAITGPTGAGKTTLLDAICLALYHETprlsTVSQSQNDLMTRDTAECL 80
Cdd:PRK02224    1 MRFDRVRLENFKCYA---DADLRLED----GVTVIHGVNGSGKSSLLEACFFALYGSK----ALDDTLDDVITIGAEEAE 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   81 AEVEFEVKGESYRAfwsQNRARNQPDgnlqvpRVELARC--ADGKILADKVKDKLEMTASLTGLDYGRFTRSMLLSQGQF 158
Cdd:PRK02224   70 IELWFEHAGGEYHI---ERRVRLSGD------RATTAKCvlETPEGTIDGARDVREEVTELLRMDAEAFVNCAYVRQGEV 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  159 AAFLNAKPKERAELLEELTgteiygQISAL--VFEKHKTARTDLEKLQAQASGvsllapeqqhslneslqALTDEEKQLl 236
Cdd:PRK02224  141 NKLINATPSDRQDMIDDLL------QLGKLeeYRERASDARLGVERVLSDQRG-----------------SLDQLKAQI- 196
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  237 arQQLHQQHLHwlTRQNELQAEMNRRQQALRVSQEEQENAQPQLAALNlahparqlrphwERIEEQTaaagRTRQQIQEV 316
Cdd:PRK02224  197 --EEKEEKDLH--ERLNGLESELAELDEEIERYEEQREQARETRDEAD------------EVLEEHE----ERREELETL 256
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  317 NA---RLQSVLHLRSRIRHSAQQQSAELRATMQTLtgwlteherfrlwSSELAGWRALFAQQSSDKVQLLKWQQQCASDI 393
Cdd:PRK02224  257 EAeieDLRETIAETEREREELAEEVRDLRERLEEL-------------EEERDDLLAEAGLDDADAEAVEARREELEDRD 323
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  394 RK-RDALppnpltltPEEATAALAQHTQQQPLRQRLASLHGQIAPKQKRREQLQTAIQNSQQELARRSAALEGKRQKYKE 472
Cdd:PRK02224  324 EElRDRL--------EECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEE 395
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  473 KNQQFMDVKT----------------------ICEQEARIK----DLESQRALLQSGQpCPLCGstshpaiasyQALEPG 526
Cdd:PRK02224  396 LRERFGDAPVdlgnaedfleelreerdelrerEAELEATLRtareRVEEAEALLEAGK-CPECG----------QPVEGS 464
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|...
gi 501083054  527 VNQARRDALEKEVKTLAEEGAALRGQLETLTQQLHRDESEVQA 569
Cdd:PRK02224  465 PHVETIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEA 507
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
3-580 6.04e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 60.47  E-value: 6.04e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054     3 ILSLRLKNLNSLKGEWKVDFtaepfaSNGLFAITGPTGAGKTTLLDAICLALYHET------PRLST-VSQSQNDlmtRD 75
Cdd:TIGR02169    2 IERIELENFKSFGKKKVIPF------SKGFTVISGPNGSGKSNIGDAILFALGLSSskamraERLSDlISNGKNG---QS 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    76 TAECLAEVEFevkgesyrafwsQNRARNQPDgNLQVPRvELARCADGKILADKVKDK------LEMTASLTGLDYGRFTR 149
Cdd:TIGR02169   73 GNEAYVTVTF------------KNDDGKFPD-ELEVVR-RLKVTDDGKYSYYYLNGQrvrlseIHDFLAAAGIYPEGYNV 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   150 SMllsQGQFAAFLNAKPKERAELLEELTGTEIYGqisalvfEKHKTARTDLEKLQAQASGVSLLAPEqqhsLNESLQALT 229
Cdd:TIGR02169  139 VL---QGDVTDFISMSPVERRKIIDEIAGVAEFD-------RKKEKALEELEEVEENIERLDLIIDE----KRQQLERLR 204
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   230 DEEKQLLarqqlhqqhlhwltRQNELQAEMNRRQQALRVSQEEQENAQpqlaalnlahpARQLRPHWERIEEQTAAAGRT 309
Cdd:TIGR02169  205 REREKAE--------------RYQALLKEKREYEGYELLKEKEALERQ-----------KEAIERQLASLEEELEKLTEE 259
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   310 RQQI-QEVNARLQSVLHLRSRIRHSAQQQSAELRATMQTLTGWLTEHERfrlwsselagwralfaQQSSDKVQLLKWQQQ 388
Cdd:TIGR02169  260 ISELeKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIASLER----------------SIAEKERELEDAEER 323
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   389 CASDIRKRDAlppnpltltpeeataalaqhtqqqpLRQRLASLHGQIAPKQKRREQLQTAIQNSQQELARRSAALEGKRQ 468
Cdd:TIGR02169  324 LAKLEAEIDK-------------------------LLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDK 378
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   469 KYKEKNQQFMDVKTICEQEARIKD--LESQRALLQSGQPCPLCGSTSHPAIASyqaLEPGVNQ--ARRDALEKEVKTLAE 544
Cdd:TIGR02169  379 EFAETRDELKDYREKLEKLKREINelKRELDRLQEELQRLSEELADLNAAIAG---IEAKINEleEEKEDKALEIKKQEW 455
                          570       580       590
                   ....*....|....*....|....*....|....*.
gi 501083054   545 EGAALRGQLETLTQQLHRDESEVQALVKEEQALTQE 580
Cdd:TIGR02169  456 KLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRE 491
ABC_Rad50 cd03240
ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ...
3-126 3.38e-08

ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains. The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and Walker B motifs, the Q loop, a histidine residue in the switch region, a D-loop, and a conserved LSGG sequence. This conserved sequence, LSGG, is the most specific and characteristic motif of this family and is thus known as the ABC signature sequence.


Pssm-ID: 213207 [Multi-domain]  Cd Length: 204  Bit Score: 54.92  E-value: 3.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    3 ILSLRLKNLNSLKGEWKVDFTaepfasNGLFAITGPTGAGKTTLLDAICLALYHETPRLSTVSQSQNDlMTRDTAEcLAE 82
Cdd:cd03240     1 IDKLSIRNIRSFHERSEIEFF------SPLTLIVGQNGAGKTTIIEALKYALTGELPPNSKGGAHDPK-LIREGEV-RAQ 72
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 501083054   83 VEFE---VKGESYRAFWSQNRARN-----QPDGNLQVPRvELARCADG-KILA 126
Cdd:cd03240    73 VKLAfenANGKKYTITRSLAILENvifchQGESNWPLLD-MRGRCSGGeKVLA 124
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
197-559 7.97e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 53.53  E-value: 7.97e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   197 RTDLEKLQAQASGVSLLAPEQQHSLNESLQALTDEEKQLLARQQLHQQHLHWLTRQNELQAEMNRRQQALrvsQEEQENA 276
Cdd:TIGR02169  680 RERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSL---EQEIENV 756
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   277 QPQLAALNLAHPARQLRPHWERIEEQTAAAGRTRQQIQEVNARLQSVLHLRSRIRHSAQQQSAELRAtmQTLTGWLTEHE 356
Cdd:TIGR02169  757 KSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNR--LTLEKEYLEKE 834
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   357 RfrlwSSELAGWRALFAQQSSDKvqllkwQQQCASDIRKRDalppnpLTLTPEEATAALAQhtqqqpLRQRLASLHG--- 433
Cdd:TIGR02169  835 I----QELQEQRIDLKEQIKSIE------KEIENLNGKKEE------LEEELEELEAALRD------LESRLGDLKKerd 892
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   434 ----QIAPKQKRREQLQTAIQNSQQELARRSAALEGKRQKYKEKNQQFMDVKTICEQEARIKDLESQRALLQsgqpcplc 509
Cdd:TIGR02169  893 eleaQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLEDVQAELQRVE-------- 964
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   510 gstshpaiASYQALEPgVN----------QARRDALEKEVKTLAEEGAALRGQLETLTQQ 559
Cdd:TIGR02169  965 --------EEIRALEP-VNmlaiqeyeevLKRLDELKEKRAKLEEERKAILERIEEYEKK 1015
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
424-877 1.91e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 52.25  E-value: 1.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  424 LRQRLASLHGQIAPKQKRREQLQTAIQNSQQELARRSAALEGKRQKYKEKNQQFMdvkticEQEARIKDLESQRALLQSG 503
Cdd:COG1196   237 LEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEY------ELLAELARLEQDIARLEER 310
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  504 QpcplcgSTSHPAIASYQALEpGVNQARRDALEKEVKTLAEEGAALRGQLETLTQQLHRDESEVQALVKEEQALTQEWQT 583
Cdd:COG1196   311 R------RELEERLEELEEEL-AELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEE 383
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  584 LCDALnvtLHPQDDISPWLTARQDYEQQLYQLSQR--HMLQAQIAAHTGQVTQFQQQIDQRQTTLLSELRRYGLSLPADG 661
Cdd:COG1196   384 LAEEL---LEALRAAAELAAQLEELEEAEEALLERleRLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEA 460
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  662 EEASWLNARADDAQTWQQRQTELGELQTRIAQLTPLLETLPETDILPESDERVALDNWRQVHDDCVSLQSQWQTLQQQEA 741
Cdd:COG1196   461 LLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAAL 540
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  742 Q------------EMQRVAQAQAHFDAALKASvfddRAAFLAALLDDETIARLEQHRQALENQLQQAQALAAQANQALAE 809
Cdd:COG1196   541 EaalaaalqnivvEDDEVAAAAIEYLKAAKAG----RATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYY 616
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501083054  810 HQQHPPEGLDLTLTPEHIQQAVAQLTGQLRDNTTRQGEIRQQLKQDANNRQQQQSLMLEIENASQQVE 877
Cdd:COG1196   617 VLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEEL 684
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
424-588 3.17e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 49.54  E-value: 3.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  424 LRQRLASLHGQIAPKQKRREQLQTAIQNSQQELARRSAALEGKRQKYKEKNQQFMDVKTICEQEARIKDLESQRALLQSg 503
Cdd:COG1579    29 LPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKEYEALQKEIESLKRRISD- 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  504 qpcplcgstshpaiASYQALEpgvNQARRDALEKEVKTLAEEGAALRGQLETLTQQLhrdESEVQALVKEEQALTQEWQT 583
Cdd:COG1579   108 --------------LEDEILE---LMERIEELEEELAELEAELAELEAELEEKKAEL---DEELAELEAELEELEAEREE 167

                  ....*
gi 501083054  584 LCDAL 588
Cdd:COG1579   168 LAAKI 172
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
169-694 4.03e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 51.09  E-value: 4.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  169 RAELLEELTGTEIYGQISALVFEKHKTARTDLEKLQAQASGVSLLAPEQQHSLNESLQALTDEEKQLLARQQLHQQHLHW 248
Cdd:COG1196   287 QAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEA 366
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  249 LTRQNELQAEMNRRQQALRVSQEEQENAQpQLAALNLAHPARQLRPHWERIEEQTAAAGRTRQQIQEVNARLQSVLHLRS 328
Cdd:COG1196   367 LLEAEAELAEAEEELEELAEELLEALRAA-AELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALE 445
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  329 RIRHSAQQQSAELRATMQTLTGWLTEHERFRLWSSELAGWRALFAQQSSDKVQLLKWQQQCASDIRKRDALPPNPLtLTP 408
Cdd:COG1196   446 EAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRG-LAG 524
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  409 EEATAALAQHTQQQPLRQRLASLHGQIApkQKRREQLQTAIQNSQQELARRSAALEGKRQKYKEKNQQFMDVKTICEQEA 488
Cdd:COG1196   525 AVAVLIGVEAAYEAALEAALAAALQNIV--VEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVD 602
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  489 RIKDLESQRALLQSGQpcplcGSTSHPAIASYQALEPGVNQARRDALEKEVKTLAEEGAALRGQLETLTQQLHRDESEVQ 568
Cdd:COG1196   603 LVASDLREADARYYVL-----GDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEA 677
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  569 ALVKEEQALTQEWQTLcdalnvtlhpqddispwlTARQDYEQQLYQLSQRHMLQAQIAAHTGQVTQFQQQIDQRQTTLLS 648
Cdd:COG1196   678 EAELEELAERLAEEEL------------------ELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLE 739
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 501083054  649 ELRRYGLSLPADGEEASwlnARADDAQTWQQRqteLGELQTRIAQL 694
Cdd:COG1196   740 ELLEEEELLEEEALEEL---PEPPDLEELERE---LERLEREIEAL 779
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
411-627 1.45e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  411 ATAALAQHTQQQPLRQRLASLHGQIAPKQKRREQLQTAIQNSQQELARRSAALEGKRQKYKEKNQQfmdvktICEQEARI 490
Cdd:COG4942    12 ALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQE------LAALEAEL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  491 KDLESQRALLQ----------------------SGQPCPLCGSTSHPAIASYQALEPGVNQARRDALEKEVKTLaEEGAA 548
Cdd:COG4942    86 AELEKEIAELRaeleaqkeelaellralyrlgrQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADL-AELAA 164
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501083054  549 LRGQLETLTQQLHRDESEVQALVKEEQALTQEWQTLCDALNVTLhpqDDISPWLTARQDYEQQLYQLSQRhmLQAQIAA 627
Cdd:COG4942   165 LRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKEL---AELAAELAELQQEAEELEALIAR--LEAEAAA 238
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
529-955 1.94e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.78  E-value: 1.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  529 QARRDALEKEVKTLAEEGAALRGQLETLTQQLHRDESEVQALVKEEQALTQEWQTLCDALNVTlhpQDDISPWLTARQDY 608
Cdd:COG1196   245 EAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARL---EERRRELEERLEEL 321
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  609 EQQLYQLSQRH-MLQAQIAAHTGQVTQFQQQIDQRQTTLLSELRRYglsLPADGEEASWLNARADDAQTWQQRQTELGEL 687
Cdd:COG1196   322 EEELAELEEELeELEEELEELEEELEEAEEELEEAEAELAEAEEAL---LEAEAELAEAEEELEELAEELLEALRAAAEL 398
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  688 QTRIAQLTPLLETLPETDILPESDERVALDNWRQVHDDCVSLQSQWQTLQQQEAQEMQRVAQAQAHfDAALKASVFDDRA 767
Cdd:COG1196   399 AAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLEL-LAELLEEAALLEA 477
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  768 AFLAALLDDETIARLEQHRQALENQLQQAQALAAQANQALAEHQQHPPEGLDLTLTPEHIQQAVAQLTGQL----RDNTT 843
Cdd:COG1196   478 ALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALqnivVEDDE 557
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  844 RQGEIRQQLKQDANNR------QQQQSLMLEIENASQQVEDWGYLNALIGSKEGDKFRKFAQGLTLDNLVWLANNQLTRL 917
Cdd:COG1196   558 VAAAAIEYLKAAKAGRatflplDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALR 637
                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 501083054  918 HGRYLLQRKASEALELEVVDTWQADAVRDTRTLSGGES 955
Cdd:COG1196   638 RAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALL 675
AAA_29 pfam13555
P-loop containing region of AAA domain;
26-50 2.03e-05

P-loop containing region of AAA domain;


Pssm-ID: 433304 [Multi-domain]  Cd Length: 61  Bit Score: 42.97  E-value: 2.03e-05
                           10        20
                   ....*....|....*....|....*
gi 501083054    26 PFASNGLFAITGPTGAGKTTLLDAI 50
Cdd:pfam13555   18 PIDPRGNTLLTGPSGSGKSTLLDAI 42
ABC_Class2 cd03227
ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems ...
26-54 3.76e-05

ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems involved in cellular processes other than transport. These families are characterized by the fact that the ABC subunit is made up of duplicated, fused ABC modules (ABC2). No known transmembrane proteins or domains are associated with these proteins.


Pssm-ID: 213194 [Multi-domain]  Cd Length: 162  Bit Score: 45.04  E-value: 3.76e-05
                          10        20
                  ....*....|....*....|....*....
gi 501083054   26 PFASNGLFAITGPTGAGKTTLLDAICLAL 54
Cdd:cd03227    17 TFGEGSLTIITGPNGSGKSTILDAIGLAL 45
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
1-55 6.08e-05

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 44.54  E-value: 6.08e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 501083054    1 MKILSLRLKNLNSLKGewkVDFTAEPfasNGLFAITGPTGAGKTTLLDAICLALY 55
Cdd:cd00267     2 IENLSFRYGGRTALDN---VSLTLKA---GEIVALVGPNGSGKSTLLRAIAGLLK 50
SbcC_Walker_B pfam13558
SbcC/RAD50-like, Walker B motif; This entry represents the Walker B domain of RAD50 from ...
931-1002 6.56e-05

SbcC/RAD50-like, Walker B motif; This entry represents the Walker B domain of RAD50 from eukaryotes and the prokaryotic homolog SbcCD complex subunit C. RAD50-ATPase forms a complex with Mre11-nuclease that detects and processes diverse and obstructed DNA ends. This domain is separated of the Walker A domain by a long coiled-coil domain and forms the nucleotide-binding domain (NBD) when the coiled coils fold back on themselves and bring together Walker A and B domains. Two RAD50-NBDs forms heterotetramers with a Mre11 nuclease dimer that assemble as catalytic head module that binds and cleaves DNA in an ATP-dependent reaction. Through secondary structural analysis, it has been suggested that there is a wide structural conservation in the Rad50/SMC protein family as seen in structural similarities between RAD50's hook and ABC-ATPase MukB's elbow region.


Pssm-ID: 463921 [Multi-domain]  Cd Length: 90  Bit Score: 42.61  E-value: 6.56e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501083054   931 LELEVV--DTWQADAVRDTRTLSGGE-----SFLVSLALALALSDLVSHKTRIDSLFLDEGFGTLDSETLDTALDALDA 1002
Cdd:pfam13558   12 FEVEVRdeDGSEVETYRRSGGLSGGEkqllaYLPLAAALAAQYGSAEGRPPAPRLVFLDEAFAKLDEENIRTALELLRA 90
mukB PRK04863
chromosome partition protein MukB;
143-558 1.12e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 46.49  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  143 DYGRFTRSMLLSQGQFAAFLNAKPKERAELLEELTG--TEIYGQISALVFEKHKTARTdLEKLQAQASGVSLLapEQQHS 220
Cdd:PRK04863  255 DRDLFKHLITESTNYVAADYMRHANERRVHLEEALElrRELYTSRRQLAAEQYRLVEM-ARELAELNEAESDL--EQDYQ 331
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  221 -----LNESLQALTDEEKQLLARQQLHQQHLHwLTRQNELQAEMNRRQQALRVSQEEQENAQPQLAAlnlahparQLRPH 295
Cdd:PRK04863  332 aasdhLNLVQTALRQQEKIERYQADLEELEER-LEEQNEVVEEADEQQEENEARAEAAEEEVDELKS--------QLADY 402
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  296 WERIEEQTAAAGRTRQQIQEVnARLQSVLHLRSRIRHSAQQQSAELRATMQTLTGWLTEHERfRLWSSELAgwralfAQQ 375
Cdd:PRK04863  403 QQALDVQQTRAIQYQQAVQAL-ERAKQLCGLPDLTADNAEDWLEEFQAKEQEATEELLSLEQ-KLSVAQAA------HSQ 474
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  376 SSDKVQLLkwqQQCASDIRKRDALppnpltltpEEATAALAQHTQQQPLRQRLASLHGQIAPKQKRREQLQTAIQ----- 450
Cdd:PRK04863  475 FEQAYQLV---RKIAGEVSRSEAW---------DVARELLRRLREQRHLAEQLQQLRMRLSELEQRLRQQQRAERllaef 542
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  451 ------------NSQQELARRSAALEGKRQKYKEKNQQFMDVKTICEQ-EARIKDLESQRALLQSGQP-----CPLCGST 512
Cdd:PRK04863  543 ckrlgknlddedELEQLQEELEARLESLSESVSEARERRMALRQQLEQlQARIQRLAARAPAWLAAQDalarlREQSGEE 622
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 501083054  513 shpaIASYQALEpgvnQARRDALEKEVKT------LAEEGAALRGQLETLTQ 558
Cdd:PRK04863  623 ----FEDSQDVT----EYMQQLLERERELtverdeLAARKQALDEEIERLSQ 666
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
251-476 1.99e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.75  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  251 RQNELQAEMNRRQQALRVSQEEQENAQPQLAALNlahparqlrphwERIEEQTAAAGRTRQQIQEVNARLQSvlhlrsri 330
Cdd:COG4942    28 ELEQLQQEIAELEKELAALKKEEKALLKQLAALE------------RRIAALARRIRALEQELAALEAELAE-------- 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  331 rhsAQQQSAELRATMQTLTGWLTEHERFRLWSSELAGWRALFAQQS-SDKVQLLKWQQQCASDIRKRdalppnplTLTPE 409
Cdd:COG4942    88 ---LEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDfLDAVRRLQYLKYLAPARREQ--------AEELR 156
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501083054  410 EATAALAQhtQQQPLRQRLASLHGQIAPKQKRREQLQTAIQNSQQELARRSAALEGKRQKYKEKNQQ 476
Cdd:COG4942   157 ADLAELAA--LRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQE 221
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
167-343 2.18e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  167 KERAELLEELTGTeiygqisalvFEKHKTARTDLEKLQAQASGVSL--------LAPEQQHSLNESLQALTDEEKQLLAR 238
Cdd:COG4913   248 REQIELLEPIREL----------AERYAAARERLAELEYLRAALRLwfaqrrleLLEAELEELRAELARLEAELERLEAR 317
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  239 QQLHQQHLHWLTRQ---------NELQAEMNRRQQALRVSQEEQENAQPQLAALNLAHP----------------ARQLR 293
Cdd:COG4913   318 LDALREELDELEAQirgnggdrlEQLEREIERLERELEERERRRARLEALLAALGLPLPasaeefaalraeaaalLEALE 397
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 501083054  294 PHWERIEEQTAAAGRT----RQQIQEVNARLQSVLHLRSRIRHSAQQQSAELRA 343
Cdd:COG4913   398 EELEALEEALAEAEAAlrdlRRELRELEAEIASLERRKSNIPARLLALRDALAE 451
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1-570 3.89e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.67  E-value: 3.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    1 MKILSLRLKNLNSLKgEWKVDFTaepfasNGLFAITGPTGAGKTTLLDAICLALYHETPrlSTVSQSQNDLMTRD-TAEC 79
Cdd:PRK03918    1 MKIEELKIKNFRSHK-SSVVEFD------DGINLIIGQNGSGKSSILEAILVGLYWGHG--SKPKGLKKDDFTRIgGSGT 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   80 LAEVEFEVKGESYRAFWSQNRArnqpdgnlqvprVELARCADG-KILADKVKDKLEMTASLtgLDYGRFTRSMLLSQGQF 158
Cdd:PRK03918   72 EIELKFEKNGRKYRIVRSFNRG------------ESYLKYLDGsEVLEEGDSSVREWVERL--IPYHVFLNAIYIRQGEI 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  159 AAFLNAKpKERAELLEELTGTEIYGQI---SALVFEKHKTARTDLEKLQAQASGVSLLAPEQQHSLNESLQALTDEEKQL 235
Cdd:PRK03918  138 DAILESD-ESREKVVRQILGLDDYENAyknLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSEL 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  236 larqqlhqqhlhwltrqNELQAEMnrrqQALRVSQEEQENAQPQLAALNLAhpARQLRPHWERIEEQTaaaGRTRQQIQE 315
Cdd:PRK03918  217 -----------------PELREEL----EKLEKEVKELEELKEEIEELEKE--LESLEGSKRKLEEKI---RELEERIEE 270
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  316 VNARLQSvlhLRSRIRHSAQ-QQSAE----LRATMQTLTGWLTEHE-RFRLWSSELAGWRALFaQQSSDKVQLLKWQQQC 389
Cdd:PRK03918  271 LKKEIEE---LEEKVKELKElKEKAEeyikLSEFYEEYLDELREIEkRLSRLEEEINGIEERI-KELEEKEERLEELKKK 346
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  390 ASDIRKR-DALPPNPLTLtpEEATAALAqhtQQQPLRQRLASLhgqiaPKQKRREQLqtaiqnsqQELARRSAALEGKRQ 468
Cdd:PRK03918  347 LKELEKRlEELEERHELY--EEAKAKKE---ELERLKKRLTGL-----TPEKLEKEL--------EELEKAKEEIEEEIS 408
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  469 KYKEKnqqfmdvktICEQEARIKDLESQRALLQSGQP-CPLCG---STSHPA--IASYqalepgvnQARRDALEKEVKTL 542
Cdd:PRK03918  409 KITAR---------IGELKKEIKELKKAIEELKKAKGkCPVCGrelTEEHRKelLEEY--------TAELKRIEKELKEI 471
                         570       580
                  ....*....|....*....|....*...
gi 501083054  543 AEEGAALRGQLETLTQQLHRdESEVQAL 570
Cdd:PRK03918  472 EEKERKLRKELRELEKVLKK-ESELIKL 498
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
169-695 3.91e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.52  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  169 RAELLEEltgTEIYGQISALV--FEKHKTARTDLEKLQAQasgVSLLAPEQQHslNESLQALT------DEEKQLLARQQ 240
Cdd:COG4913   214 REYMLEE---PDTFEAADALVehFDDLERAHEALEDAREQ---IELLEPIREL--AERYAAARerlaelEYLRAALRLWF 285
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  241 LHQQHLHWLTRQNELQAEMNRRQQALRVSQEEQENAQPQLAALNLA---HPARQLrphwERIEEQTAAAGRTRQQIQEVN 317
Cdd:COG4913   286 AQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQirgNGGDRL----EQLEREIERLERELEERERRR 361
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  318 ARLQSVLH---------------LRSRIRHSAQQQSAELRATMQTLTGWLTEHERFRlwsSELAGWRALFAQQSSDKVQL 382
Cdd:COG4913   362 ARLEALLAalglplpasaeefaaLRAEAAALLEALEEELEALEEALAEAEAALRDLR---RELRELEAEIASLERRKSNI 438
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  383 LKWQQQCASDIR-----KRDALPP----------------------NPLTLT---PEEATAALAQHTQQQPLRQRLaslH 432
Cdd:COG4913   439 PARLLALRDALAealglDEAELPFvgelievrpeeerwrgaiervlGGFALTllvPPEHYAAALRWVNRLHLRGRL---V 515
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  433 GQIAPKQKRREQLQTAIQNSqqeLARRSAALEGKRQKY--KEKNQQFMDVKtiCEQEARIKDleSQRALLQSGQpcplcg 510
Cdd:COG4913   516 YERVRTGLPDPERPRLDPDS---LAGKLDFKPHPFRAWleAELGRRFDYVC--VDSPEELRR--HPRAITRAGQ------ 582
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  511 sTSHP----------AIASYQALepGV-NQARRDALEKEVKTLAEEGAALRGQLETLTQQLHR----------------D 563
Cdd:COG4913   583 -VKGNgtrhekddrrRIRSRYVL--GFdNRAKLAALEAELAELEEELAEAEERLEALEAELDAlqerrealqrlaeyswD 659
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  564 ESEVQALVKEEQALTQEWQTLCDALNVTLHPQDDISPWLTARQDYEQQLYQLSQRH-MLQAQIAAHTGQVTQfqqqidqr 642
Cdd:COG4913   660 EIDVASAEREIAELEAELERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIgRLEKELEQAEEELDE-------- 731
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|...
gi 501083054  643 qttllSELRRYGLSLPADGEEASWLNARADDAQTWQQRQTELGELQTRIAQLT 695
Cdd:COG4913   732 -----LQDRLEAAEDLARLELRALLEERFAAALGDAVERELRENLEERIDALR 779
ABC_SMC_head cd03239
The SMC head domain belongs to the ATP-binding cassette superfamily; The structural ...
3-54 5.64e-04

The SMC head domain belongs to the ATP-binding cassette superfamily; The structural maintenance of chromosomes (SMC) proteins are essential for successful chromosome transmission during replication and segregation of the genome in all organisms. SMCs are generally present as single proteins in bacteria, and as at least six distinct proteins in eukaryotes. The proteins range in size from approximately 110 to 170 kDa, and each has five distinct domains: amino- and carboxy-terminal globular domains, which contain sequences characteristic of ATPases, two coiled-coil regions separating the terminal domains , and a central flexible hinge. SMC proteins function together with other proteins in a range of chromosomal transactions, including chromosome condensation, sister-chromatid cohesion, recombination, DNA repair, and epigenetic silencing of gene expression.


Pssm-ID: 213206 [Multi-domain]  Cd Length: 178  Bit Score: 41.91  E-value: 5.64e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 501083054    3 ILSLRLKNLNSLKGEWKVDFtaepfaSNGLFAITGPTGAGKTTLLDAICLAL 54
Cdd:cd03239     1 IKQITLKNFKSYRDETVVGG------SNSFNAIVGPNGSGKSNIVDAICFVL 46
SbcC COG0419
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
844-1016 6.27e-04

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];


Pssm-ID: 440188 [Multi-domain]  Cd Length: 204  Bit Score: 42.30  E-value: 6.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  844 RQGEIRQQLKQDANNRQQQqslmleienasqqvedwgyLNALIGSKEGDKFRKfaqglTLDNLVWLANNQLTRLHGRYLL 923
Cdd:COG0419    87 RQGEFAEFLEAKPSERKEA-------------------LKRLLGLEIYEELKE-----RLKELEEALESALEELAELQKL 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  924 QRKASEALElevvdtwqadAVRDTRTLSGGESFLVSLalalalsdlvshkTRIDSLFLDegFGTLDSETLDTALDALDAL 1003
Cdd:COG0419   143 KQEILAQLS----------GLDPIETLSGGERLRLAL-------------ADLLSLILD--FGSLDEERLERLLDALEEL 197
                         170
                  ....*....|...
gi 501083054 1004 natgktiGVISHV 1016
Cdd:COG0419   198 -------AIITHV 203
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
409-579 7.65e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.47  E-value: 7.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  409 EEATAALAQHTQQQplrqRLASLHGQIAPKQKRREQLQTAIQNSQQELAR---RSAALEGKRQKYKEKNQQFMDVKTICE 485
Cdd:COG3206   192 EEAEAALEEFRQKN----GLVDLSEEAKLLLQQLSELESQLAEARAELAEaeaRLAALRAQLGSGPDALPELLQSPVIQQ 267
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  486 QEARIKDLESQRALLQSGqpcplcGSTSHPAIASYQALEPGVNQARRDALEKEVKTLAEEGAALRGQLETLTQQLHRDES 565
Cdd:COG3206   268 LRAQLAELEAELAELSAR------YTPNHPDVIALRAQIAALRAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEA 341
                         170
                  ....*....|....
gi 501083054  566 EVQALVKEEQALTQ 579
Cdd:COG3206   342 RLAELPELEAELRR 355
UreG cd05540
urease accessory protein UreG; UreG is one of the four accessory proteins of urease. Urease is ...
35-80 8.67e-04

urease accessory protein UreG; UreG is one of the four accessory proteins of urease. Urease is an enzyme which catalyzes the decomposition of urea to form ammonia and carbon dioxide. Bacterial urease is a trimer of three subunits which are encoded by genes ureA, ureB, and ureC. Up to four accessory proteins (ureD, ureE, ureF, and ureG) are required for urease catalytical function. UreG may play an important role in nickel incorporation of the urease metallocenter. UreG is a member of the Fer4_NifH superfamily which contains an ATP-binding domain. Proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.


Pssm-ID: 349776  Cd Length: 191  Bit Score: 41.48  E-value: 8.67e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 501083054   35 ITGPTGAGKTTLLDAICLALyHETPRLSTVSqsqNDLMTRDTAECL 80
Cdd:cd05540     5 IGGPVGSGKTALVEALCRAL-RDKYSIAVVT---NDIYTKEDAEFL 46
PRK11281 PRK11281
mechanosensitive channel MscK;
190-341 1.58e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.59  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  190 FEKHKTARTDLEKLQAQASGvsllAPEQQHSLNESLQALTDEEKQLlARQQLHQQHLhwltrqNELQAEMNRRQQALRVS 269
Cdd:PRK11281   72 LDKIDRQKEETEQLKQQLAQ----APAKLRQAQAELEALKDDNDEE-TRETLSTLSL------RQLESRLAQTLDQLQNA 140
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501083054  270 QEEQENAQPQLAALnlahparQLRPhwERIEEQTAAAgrtRQQIQEVNARLQSVLHLRSRIRHSAQQQ-SAEL 341
Cdd:PRK11281  141 QNDLAEYNSQLVSL-------QTQP--ERAQAALYAN---SQRLQQIRNLLKGGKVGGKALRPSQRVLlQAEQ 201
YbjD COG3593
Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM ...
1-60 2.24e-03

Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM domains [Replication, recombination and repair];


Pssm-ID: 442812 [Multi-domain]  Cd Length: 359  Bit Score: 41.53  E-value: 2.24e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    1 MKILSLRLKNLNSLKGEwKVDFtaepfaSNGLFAITGPTGAGKTTLLDAICLALYHETPR 60
Cdd:COG3593     1 MKLEKIKIKNFRSIKDL-SIEL------SDDLTVLVGENNSGKSSILEALRLLLGPSSSR 53
ABCG_EPDR cd03213
Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette ...
4-62 2.63e-03

Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. Compared to other members of the ABC transporter subfamilies, the ABCG transporter family is composed of proteins that have an ATP-binding cassette domain at the N-terminus and a TM (transmembrane) domain at the C-terminus.


Pssm-ID: 213180 [Multi-domain]  Cd Length: 194  Bit Score: 40.23  E-value: 2.63e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501083054    4 LSLRLKNLN-SLKGEWK---------VDFTAEPfasNGLFAITGPTGAGKTTLLDAicLALYHETPRLS 62
Cdd:cd03213     2 VTLSFRNLTvTVKSSPSksgkqllknVSGKAKP---GELTAIMGPSGAGKSTLLNA--LAGRRTGLGVS 65
ABC_RecN cd03241
ATP-binding cassette domain of RecN; RecN ATPase involved in DNA repair; similar to ABC ...
3-114 4.06e-03

ATP-binding cassette domain of RecN; RecN ATPase involved in DNA repair; similar to ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213208 [Multi-domain]  Cd Length: 276  Bit Score: 40.26  E-value: 4.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054    3 ILSLRLKNlNSLKGEWKVDFtaepfaSNGLFAITGPTGAGKTTLLDAICLALyhetprlstVSQSQNDLMTRDTAECLAE 82
Cdd:cd03241     1 LLELSIKN-FALIEELELDF------EEGLTVLTGETGAGKSILLDALSLLL---------GGRASADLIRSGAEKAVVE 64
                          90       100       110
                  ....*....|....*....|....*....|..
gi 501083054   83 VEFEVKGESyRAFWSQNRARNQPDGNLQVPRV 114
Cdd:cd03241    65 GVFDISDEE-EAKALLLELGIEDDDDLIIRRE 95
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
420-584 6.69e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 40.39  E-value: 6.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   420 QQQPLRQRLASLHGQIapkqkrrEQLQTAIQNSQQELARRSAALEGKRQKYKEKNQQFMDVK-TICEQEARIKDLESQRA 498
Cdd:TIGR04523  378 ENQSYKQEIKNLESQI-------NDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKeTIIKNNSEIKDLTNQDS 450
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   499 LLQSgqpcplcgstshpaiaSYQALEpgvnqARRDALEKEVKTLAEEGAALRGQLETLTQQLHRDESEVQALVKEEQALT 578
Cdd:TIGR04523  451 VKEL----------------IIKNLD-----NTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELE 509

                   ....*.
gi 501083054   579 QEWQTL 584
Cdd:TIGR04523  510 EKVKDL 515
HypB COG0378
Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase [Posttranslational modification, ...
25-82 7.79e-03

Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440147 [Multi-domain]  Cd Length: 200  Bit Score: 38.89  E-value: 7.79e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054   25 EPFASNGLFAIT--GPTGAGKTTLLDAICLALyHETPRLSTVSqsqNDLMTRDTAECLAE 82
Cdd:COG0378     6 ALFAEKGVLAVNlmGSPGSGKTTLLEKTIRAL-KDRLRIAVIE---GDIYTTEDAERLRA 61
AAA_15 pfam13175
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
1-50 8.33e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433011 [Multi-domain]  Cd Length: 392  Bit Score: 39.89  E-value: 8.33e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 501083054     1 MKILSLRLKNLNSLKgEWKVDFtaepfaSNGLFAITGPTGAGKTTLLDAI 50
Cdd:pfam13175    1 MKIKSIIIKNFRCLK-DTEIDL------DEDLTVLIGKNNSGKSSILEAL 43
ABC_Rad50 cd03240
ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ...
949-1039 9.95e-03

ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains. The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and Walker B motifs, the Q loop, a histidine residue in the switch region, a D-loop, and a conserved LSGG sequence. This conserved sequence, LSGG, is the most specific and characteristic motif of this family and is thus known as the ABC signature sequence.


Pssm-ID: 213207 [Multi-domain]  Cd Length: 204  Bit Score: 38.74  E-value: 9.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501083054  949 TLSGGESFLVSLALALALSDLVShkTRIDSLFLDEGFGTLDSETLDTAL-DALDALNA-TGKTIGVISHVEAMKERIPVQ 1026
Cdd:cd03240   115 RCSGGEKVLASLIIRLALAETFG--SNCGILALDEPTTNLDEENIEESLaEIIEERKSqKNFQLIVITHDEELVDAADHI 192
                          90
                  ....*....|...
gi 501083054 1027 IKVKKiNGLGYSK 1039
Cdd:cd03240   193 YRVEK-DGRQKSR 204
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH