|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
26-438 |
0e+00 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 565.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 26 VIATGIGNAMEWFDFGLYAYLAVILSQLFFSGvDNSGLQLVLTFGTFAAAFLVRPIGGIFFGRIGDKYGRKIVLSTTIIL 105
Cdd:cd17366 1 VKAAALGNAMEWFDFGVYGYLAVTIGKVFFPG-GDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIIL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 106 MALSTLFIALLPTYEQIGVWAPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTI 185
Cdd:cd17366 80 MAASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 186 LTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRhldespifqemekaqeesedneqfsfmdilkyhkkDFLLSTVIVAF 265
Cdd:cd17366 160 LTLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLRR-----------------------------------PLLICIGLVLV 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 266 FNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLALCSIPAFLLIGNGH 345
Cdd:cd17366 205 FNVTNYMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGS 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 346 IVAMFAGIFILGFFLSVYEGTLPSLLPALFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHATGNPLAPAFYLTGVSV 425
Cdd:cd17366 285 IAAIFIGLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGNPLMPAYYLMVAAV 364
|
410
....*....|...
gi 501218165 426 IGLIVFSVLFVTT 438
Cdd:cd17366 365 VGLVAVLFLTETA 377
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
12-462 |
7.21e-148 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 431.44 E-value: 7.21e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 12 QDVNIVNSKQAKKAVIATGIGNAMEWFDFGLYAYLAVILSQLFFSGVDnSGLQLVLTFGTFAAAFLVRPIGGIFFGRIGD 91
Cdd:PRK10642 4 RDVTIIDDGKLRKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGAD-PSVQMIAALATFSVPFLIRPLGGLFFGMLGD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 92 KYGRKIVLSTTIILMALSTLFIALLPTYEQIGVWAPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIG 171
Cdd:PRK10642 83 KYGRQKILAITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 172 TLSGYIAASVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFQE-MEKAQEESEDNEQ----FSFM 246
Cdd:PRK10642 163 SIAGFVLGAGVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQhVDKLEQGDREGLQdgpkVSFK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 247 DILKYHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIG 326
Cdd:PRK10642 243 EIATKHWRSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVILG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 327 LLGLALCSIPAFLLIGNGHIVAMFAGIFILGFFLSVYEGTLPSLLPALFFTDVRYRALSISFNISVSIfGGTTPLVCSYL 406
Cdd:PRK10642 323 SVALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLV-AGLTPTLAAWL 401
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 501218165 407 VHATGNPLAPAFYLTGVSVIGLIVfSVLFVTTSGRALKGSYPTVESKKEAHQIAKE 462
Cdd:PRK10642 402 VESTQNLMMPAYYLMVVAVIGLIT-GVTMKETANRPLKGATPAASDIQEAKEILVE 456
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
23-429 |
3.48e-128 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 378.02 E-value: 3.48e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 23 KKAVIATGIGNAMEWFDFGLYAYLAV-ILSQLFFSGVDnSGLQLVLTFGTFAAAFLVRPIGGIFFGRIGDKYGRKIVLST 101
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAAAlVFNKLFFPAVD-PAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 102 TIILMALSTLFIALLPTYEQIGVWAPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASV 181
Cdd:cd17369 80 TLLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 182 IVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFQEMEKAQEEsednEQFSFMDILKYHKKDFLLSTV 261
Cdd:cd17369 160 VFLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQV----VRAPLVEVLRRHWRALLLAIG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 262 IVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLALCSIPAFLLI 341
Cdd:cd17369 236 LRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 342 GNG-HIVAMFAGIFILGFFLSVYEGTLPSLLPALFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHATGNPLAPAFYL 420
Cdd:cd17369 316 DTGsTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAATGSWWPVALYL 395
|
....*....
gi 501218165 421 TGVSVIGLI 429
Cdd:cd17369 396 AALAVISLV 404
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
32-428 |
2.78e-123 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 365.06 E-value: 2.78e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 32 GNAMEWFDFGLYAYLAVILSQLFFSGVDNSGLQLVLTFGTFAAAFLVRPIGGIFFGRIGDKYGRKIVLSTTIILMALSTL 111
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 112 FIALLPTYEQIGVWAPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTILTLLLT 191
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 192 DEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFqemeKAQEESEDNEQFSFMDILKYHKKDFLLSTVIVAFFNITNY 271
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVF----EKAQEKHKKKRGPIAETLTKHRKPFLLGLGLVIATTTTFY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 272 MILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLALCSIPAF-LLIGNGHIVAMF 350
Cdd:TIGR00883 237 LITTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLmALLDSGSFTLFF 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501218165 351 AGIFILGFFLSVYEGTLPSLLPALFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHATGNPLAPAFYLTGVSVIGL 428
Cdd:TIGR00883 317 FLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYLAALALIGL 394
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
26-437 |
1.28e-99 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 305.07 E-value: 1.28e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 26 VIATGIGNAMEWFDFGLYAYLAVILSQLFFSGvDNSGLQLVLTFGTFAAAFLVRPIGGIFFGRIGDKYGRKIVLSTTIIL 105
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPS-GSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 106 MALSTLFIALLPTYEQIGVWAPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTI 185
Cdd:cd17368 80 MALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 186 LTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFQEMEKAQEESEdneqfsFMDILKYHKKDFLLSTVIVAF 265
Cdd:cd17368 160 LSLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPTRRE------LFALLANNRRIILLGMLLVAG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 266 FNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLALCSIPAFLLIGNGH 345
Cdd:cd17368 234 STVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAP 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 346 IVAMF-AGIFILGFFLSVYEGTLPSLLPALFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHATGNPLAPAFYLTGVS 424
Cdd:cd17368 314 SFGRLlLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAA 393
|
410
....*....|...
gi 501218165 425 VIGLIVFSVLFVT 437
Cdd:cd17368 394 LLGLLATLMLRET 406
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
26-434 |
1.41e-94 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 292.28 E-value: 1.41e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 26 VIATGIGNAMEWFDFGLYAYLAVILSQLFFSGvDNSGLQLVLTFGTFAAAFLVRPIGGIFFGRIGDKYGRKIVLSTTIIL 105
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFFPS-GDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 106 MALSTLFIALLPTYEQIGVWAPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTI 185
Cdd:cd17367 80 MAAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 186 LTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFQEMEKAQEESEdneqfSFMDILKYHKKDFLLSTVIVAF 265
Cdd:cd17367 160 LQHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASA-----GTLRELRRHPRELLLVVGLTAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 266 FNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLALCSIPAFLLIGNGH 345
Cdd:cd17367 235 GTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTD 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 346 IVAMFAGIFILGF-FLSVYEGTLPSLLPALFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHaTGNPLAPAFYLTGVS 424
Cdd:cd17367 315 SPYTAFALVLVGLvFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKS-IGHEWVFFWYVAGLI 393
|
410
....*....|
gi 501218165 425 VIGLIVFSVL 434
Cdd:cd17367 394 AISLVVYLRM 403
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
26-430 |
1.07e-78 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 249.44 E-value: 1.07e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 26 VIATGIGNAMEWFDFGLYAYLAVILSQLFfsgvdNSGLQLVLTFGTFAAAFLVRPIGGIFFGRIGDKYGRKIVLSTTIIL 105
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF-----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 106 MALSTLFIALLPTyeqigvwaPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTI 185
Cdd:cd17316 76 FGLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 186 LTLLLTDEqmlsWGWRIPFLIAAPIGLVGLYLRRhldespifqemekaqeesedneqfsfmdilkyhkkDFLLSTVIVAF 265
Cdd:cd17316 148 LIPLLSGD----WGWRILFLIGALPALLALLLRR-----------------------------------RTLLLILLWFF 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 266 FNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLALCSIPaFLLIGNGH 345
Cdd:cd17316 189 ISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALP-LFYLLSGS 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 346 IVAMFAGIFILGFFLSVYEGTLPSLLPALFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHaTGNPLAPAFYLTGVSV 425
Cdd:cd17316 268 PTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS-TGGTGVPALILALLAI 346
|
....*
gi 501218165 426 IGLIV 430
Cdd:cd17316 347 VALIV 351
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
32-442 |
1.53e-71 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 233.30 E-value: 1.53e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 32 GNAMEWFDFGLYAYLAVILSQLFFSGvDNSGLQLVLTFGTFAAAFLVRPIGGIFFGRIGDKYGRKIVLSTTIILMALSTL 111
Cdd:PRK15075 23 GNFLEMFDFFLFGFYATAIAKTFFPA-GNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLSIMASGTL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 112 FIALLPTYEQIGVWAPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTILTLLLT 191
Cdd:PRK15075 102 LIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLGYLLNQWLS 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 192 DEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFQEMEKAQEESEdneqfsFMDILKYHKKDFLLSTVIVAFFNITNY 271
Cdd:PRK15075 182 PAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLARKHRPSMRE------IFRSLAANWRIVLAGMLMVAMTTVSFY 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 272 MILSYIPSYLTQVLKVKETTGLLI---ISITMALMIPLalyFGKLSDKVGnKRVVQIGLLGLALC-SIPAFL-LIGNGHI 346
Cdd:PRK15075 256 LITVYTPTFGKTVLHLSAADSLLVtlcVGVSNFIWLPI---GGALSDRIG-RRPVLIAFTVLAILtAYPALSwLVAAPSF 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 347 VAMFAGIFILGFFLSVYEGTLPSLLPALFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHATGNPLAPAFYLTGVSVI 426
Cdd:PRK15075 332 ARMLAVELWLSFLYGSYNGAMVVALTEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWLIHVTGDKAAPGYWLSFAAVC 411
|
410
....*....|....*.
gi 501218165 427 GLIVFSVLFVTTSGRA 442
Cdd:PRK15075 412 GLIATLVLYRRRGARL 427
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
12-430 |
2.36e-67 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 222.38 E-value: 2.36e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 12 QDVNIVNSKQAKKAVIATGIGNAMEWFDFGLYAYLAVILSQLFFSGvDNSGLQLVLTFGTFAAAFLVRPIGGIFFGRIGD 91
Cdd:PRK10406 10 SKLTSSDTRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPS-GNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIAD 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 92 KYGRKIVLSTTIILMALSTLFIALLPTYEQIGVWAPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIG 171
Cdd:PRK10406 89 KHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVT 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 172 TLSGYIAASVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESpifqemeKAQEESEDNEQFSFMDILKy 251
Cdd:PRK10406 169 LIGGQLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDET-------SQQETRALKEAGSLKGLWR- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 252 HKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLA 331
Cdd:PRK10406 241 NRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 332 LCSIPAFLLIGN-GHIVAMFAGIFILGFFLSVYEGTLPSLLPALFFTDVRYRALSISFNISVSIFGGTTPLVCSYLvHAT 410
Cdd:PRK10406 321 LFTVPILSALQNvSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVALSL-KSI 399
|
410 420
....*....|....*....|
gi 501218165 411 GNPLAPAFYLTGVSVIGLIV 430
Cdd:PRK10406 400 GMETAFFWYVTLMAVVAFLV 419
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
20-430 |
2.96e-64 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 214.21 E-value: 2.96e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 20 KQAKKAVIATGIGNAMEWFDFGLYAYLA-VILSQLFFSGVdNSGLQLVLTFGTFAAAFLVRPIGGIFFGRIGDKYGRKIV 98
Cdd:PRK09952 18 SRARRAALGSFAGAVVDWYDFLLYGITAaLVFNREFFPQV-SPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRM 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 99 LSTTIILMALSTLFIALLPTYEQIGVWAPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIA 178
Cdd:PRK09952 97 LMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 179 ASVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFQemEKAQEESEDNEQFSFMDILKYHKKDFLL 258
Cdd:PRK09952 177 STGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFE--QQQHEQAAAKKRIPVIEALLRHPGAFLK 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 259 STVIVAFFNITNYMILSYIPSYLTQVLKVKE----TTGLLIISITmALMIPLalyFGKLSDKVGNKRVVQIGLLGLALCS 334
Cdd:PRK09952 255 IIALRLCELLTMYIVTAFALNYSTQNLGLPRelflNIGLLVGGLS-CLTIPC---FAWLADRFGRRRVYITGALIGTLSA 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 335 IPAFLLIGNGHIVamfaGIFILGFFL---------SVYEgtlpSLLPALFFTDVRYRALSISFNISVSIFGGTTPLVCSY 405
Cdd:PRK09952 331 FPFFMALEAQSIF----WIVFFSIMLaniahdmvvCVQQ----PMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAA 402
|
410 420
....*....|....*....|....*.
gi 501218165 406 LVHAT-GNPLAPAFYLTGVSVIGLIV 430
Cdd:PRK09952 403 LVTYFgGSWHSVAIYLLAGCLISAMT 428
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-442 |
1.43e-43 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 158.12 E-value: 1.43e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 20 KQAKKAVIATGIGNAMEWFDFGLYAYLAVILSQLFfsgvdnsGLQLVLTFGTFAAAFLVRPIGGIFFGRIGDKYGRKIVL 99
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEF-------GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 100 STTIILMALSTLFIALLPTYEQigvwapilLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGiLGSGLEIGtlSGYIAA 179
Cdd:COG2223 74 LIGLLLLGIGLLLLALAVSYWL--------LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRG-LALGLAAG--GGNLGA 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 180 SVIVTILTLLLTdeqmlSWGWRIPFLIAAP-IGLVGLYLRRHLDESPIFQEMEKAQEESEdneqfsFMDILKYhkKDFLL 258
Cdd:COG2223 143 AVAAFLAPLLIA-----AFGWRNAFLILGIlLLVVAVLAWLFLRDPPAGAAAAAKASLRD------QLEALRD--PRFWL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 259 STVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLALCSIPAF 338
Cdd:COG2223 210 LSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLA 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 339 LLIGNghIVAMFAGIFILGFFLSVYEGTLPSLLPALFFTDVRYRALSISFNISvSIFGGTTPLVCSYLVHATGNPLAPAF 418
Cdd:COG2223 290 LALGS--LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAG-GLGGFLGPLLFGALLDATGSYTAAFL 366
|
410 420
....*....|....*....|....
gi 501218165 419 YLTGVSVIGLIVFSVLFVTTSGRA 442
Cdd:COG2223 367 VFAVLALVALVLTLLLYRRPRRAA 390
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
19-386 |
1.86e-43 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 156.67 E-value: 1.86e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 19 SKQAKKAVIATGIGNAMEWFDFGLYAYLAVILSQLFfsGVDNSGLQLVLTfgtfaAAFLVRPIGGIFFGRIGDKYGRKIV 98
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADL--GASPAQAGLVVT-----AYLLGAALGAPLAGRLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 99 LSTTIILMALSTLFIALLPTYEqigvwapiLLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIA 178
Cdd:COG2814 78 LLLGLLLFALGSLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 179 ASVIVTILTLLltdeqmlsWGWRIPFLIAAPIGLVGLYLRRHLdespifqeMEKAQEESEDNEQFSFMDILKYhkKDFLL 258
Cdd:COG2814 150 GPLLGGLLADL--------FGWRWVFLVNAVLALLALLLLLRL--------LPESRPAARARLRGSLRELLRR--PRLLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 259 STVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLALCsipAF 338
Cdd:COG2814 212 LLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG---LL 288
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 501218165 339 LLIGNGHIVAMFAGIFILGFFLSVYEGTLPSLLPALFFTDVRYRALSI 386
Cdd:COG2814 289 LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGL 336
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
27-435 |
1.40e-40 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 149.76 E-value: 1.40e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 27 IATGIGNAMEWFDFGLYAYLAVILSQLFFSGVDNSGLqlvltFGTFAAAFLVrpIGGIFFGRIGDKYGRKIVLSTTIILM 106
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGL-----LGTVTLAGGA--IGGILGGILADRFGRVRVLVITILLF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 107 ALSTLFIALLPTYEQigvwapilLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTIL 186
Cdd:cd17371 75 AVFTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 187 TLLLTDEqmlsWGWRIPFLIAAPIGLVGLYLRRHLDESPIFQEMEKAQEESEDneQFSFMDIL-KYHKKDFLLSTVIVAF 265
Cdd:cd17371 147 FPLLPPE----IAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFAD--RPSLRELFsPPLLRTTLLASLLATG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 266 FNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLALCSIPAFLLIGNGH 345
Cdd:cd17371 221 ALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPT 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 346 IvaMFAGIFILGFFLSVYEGTLPSLLPALFFTDVRYRALSISFNISVSIfGGTTPLVCSYLvhATGNPLAPAFYLTGVSV 425
Cdd:cd17371 301 L--ILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRII-GALFPFLVGFL--ATSGSLGTAIAVFAAVY 375
|
410
....*....|
gi 501218165 426 IGLIVFSVLF 435
Cdd:cd17371 376 YIAGLVLALL 385
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-441 |
2.15e-38 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 143.47 E-value: 2.15e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 19 SKQAKKAVIATGIGNAMEWFDFGLYAYLAVILSQLFfsGVDNSGLQLVltfgtFAAAFLVRPIGGIFFGRIGDKYGRKIV 98
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADL--GLSAAQLGLL-----ASAFFLGYALGQIPAGLLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 99 LSTTIILMALSTLFIALLPTYEQigvwapilLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIA 178
Cdd:COG2271 78 LAIGLLLWGLATLLFGFATSFWQ--------LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 179 ASVIVTILtllltdeqMLSWGWRIPFLIAAPIGLVGLYLRrhldespifqemekaqeesedneqfsfmdilkyhkkdFLL 258
Cdd:COG2271 150 APPLLGWL--------LAAFGWRAAFLILGLPGLLLALLR-------------------------------------FWL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 259 STVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVqIGLLGLALCSIPAF 338
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKL-VLAIGLLLAALALL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 339 LLIGNGHIVAMFAGIFILGFFLSVYEGTLPSLLPALFFTDVRYRALSIsFNISVSIFGGTTPLVCSYLVHATGnpLAPAF 418
Cdd:COG2271 264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL-VNTFGFLGGALGPLLVGYLLDATG--YQAAF 340
|
410 420
....*....|....*....|...
gi 501218165 419 YLTGVSVIGLIVFSVLFVTTSGR 441
Cdd:COG2271 341 LLLAALALLAALLALLLLRETRK 363
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
24-444 |
7.54e-37 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 140.87 E-value: 7.54e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 24 KAVIATgIGNAMEWFDFGLYAYLAVILSQLFFSGVDNS----GLQLVLTFGTFAAAFLVRPIGGIFFGRIGDKYGRKIVL 99
Cdd:pfam00083 1 VALVAA-LGGFLFGYDTGVIGAFLTLIDFFKNFGLSKSvsslAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 100 STTIILMALSTLFIALLPTYeqigvWAPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGtlsgyIAA 179
Cdd:pfam00083 80 LIANVLFVIGAVLQGAAKGK-----WSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLA-----ITF 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 180 SVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIF------------------------QEMEKAQE 235
Cdd:pfam00083 150 GILLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWlvekgrleearevlaklrgvpdvdRELDEIKD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 236 ESEDNEQFSFMDI-----LKYHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKET-TGLLIISITMALMIPLALY 309
Cdd:pfam00083 230 SLEAGQEAEKASWkelfsTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSfLVTIIVGVVNFVFTFIAIF 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 310 fgkLSDKVGNKRVVQIGLLGLALC----SIPAFLLIGNGHIVAMFAGIFILgFFLSVYE---GTLPSLLPA-LFFTDVRY 381
Cdd:pfam00083 310 ---LVDRFGRRPLLLLGAAGMAICfvilGIVALLGVSKSDWAGIVAIVFIA-LFIAFFAmgwGPVPWVIVSeLFPLSVRS 385
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501218165 382 RALSISFNISVsIFGGTTPLVCSYLVHATGNPLAPAFYLtGVSVIGLIVFSVLFVTTSGRALK 444
Cdd:pfam00083 386 KAMALATAANW-LANFLIGFLFPIITDAIGLGYTFFIFA-GLLVLFIIFVFFFVPETKGRTLE 446
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
19-224 |
2.96e-36 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 135.71 E-value: 2.96e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 19 SKQAKKAVIATGIGNAMEWFDFGLYAYLAVILSQLFfsGVDNSGLQLVLTfgtfaAAFLVRPIGGIFFGRIGDKYGRKIV 98
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADL--GASSAQLGWIVS-----AYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 99 LSTTIILMALSTLFIALLPTyeqigvwaPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIA 178
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLAL 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 501218165 179 ASVIVTILTLLltdeqmlsWGWRIPFLIAAPIGLVGLYLRRHLDES 224
Cdd:COG0477 154 GPLLGGLLVAA--------LGWRWIFLINAPLGLLALVLRLRLPES 191
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
53-436 |
7.59e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 116.91 E-value: 7.59e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 53 LFFSGVDNSGLQLVLTFGTFAAAFLvrpIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLI 132
Cdd:cd17325 21 LYAESLGASVAQIGLIVAAYALAQL---LFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ--------LLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 133 ARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTILTLLltdeqmlsWGWRIPFLIAAPIGL 212
Cdd:cd17325 90 ARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA--------LGYRAPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 213 VGLYLRRHLDESPIFQEMEKAQEESEDNEQFSFMDilkyHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTG 292
Cdd:cd17325 162 LALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLL----RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 293 LLIISITMALMIPLALYFGKLSDKVGNKRVVqigLLGLALCSIPAFLLIGNGHIVAMFAGIFILGFFLSVYEGTLPSLLP 372
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRIGRKPLI---LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 501218165 373 ALFFTDVRYRALSIsFNISVSIFGGTTPLVCSYLVHATGnpLAPAFYLTGVSVIGLIVFSVLFV 436
Cdd:cd17325 315 DIVPPEGRGTAMGL-FNTAFSLGMVLGPLLGGFLYDAFG--FATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
37-400 |
4.98e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 114.05 E-value: 4.98e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 37 WFDFGLYAYLAVILSQLFFSGVDNSGLQLVLTFGTFAAAFLvrpIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALL 116
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYA---LAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 117 PTYEqigvwapiLLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTILTLlltdeqml 196
Cdd:pfam07690 83 SSLW--------LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 197 SWGWRIPFLIAAPIGLVGLYLRRHLDESPifqemEKAQEESEDNEQFSFMDILKYHKKDFLLSTVIVAF-FNITNYMILS 275
Cdd:pfam07690 147 LFGWRAAFLILAILSLLAAVLLLLPRPPP-----ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLlFGFAFFGLLT 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 276 YIPSYLtQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLALCSIPAFLLIGNGHIVAMFAGIFI 355
Cdd:pfam07690 222 YLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLL 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 501218165 356 LGFFLSVYEGTLPSLLPALFFTDVRYRALSIsFNISVSIFGGTTP 400
Cdd:pfam07690 301 LGFGFGLVFPALNALVSDLAPKEERGTASGL-YNTAGSLGGALGP 344
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
24-390 |
7.56e-25 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 107.09 E-value: 7.56e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 24 KAVIATGIGNAMEWFDFGLYAYLAVILSQLFfsgvdnsGLQLVLTFGTFAAAFLVRPIGGIFFGRIGDKYGRKIVLSTTI 103
Cdd:PRK03893 20 KAFSAAWLGYLLDGFDFVLITLVLTEVQGEF-------GLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 104 ILMALSTLFIALLPTYeqigvwapILLLIARMIQGFSTGGEYSGAMVYIAESSP----DKKRGILGSGLEIGTLSGYIAA 179
Cdd:PRK03893 93 VLFSVGTLACGFAPGY--------WTLFIARLVIGMGMAGEYGSSATYVIESWPkhlrNKASGFLISGFSIGAVVAAQVY 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 180 SVIVtiltllltdeqmLSWGWRIPFLIA-APIgLVGLYLRRHLDESPIFQEMEKAQEESEDneqfsFMDILkYHKKDFLL 258
Cdd:PRK03893 165 SLVV------------PVWGWRALFFIGiLPI-IFALWLRKNLPEAEDWKEKHAGKAPVRT-----MVDIL-YRGEHRII 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 259 STVIVAF----------FNITNYMILSYIP--------SYLTQVLKVKETTGLLIISITMAL------------------ 302
Cdd:PRK03893 226 NILLTLAaaaalwfcfaGNLQNAAIVAVLGllcaaifiSFMVQSSGKRWPTGVMLMVVVLFAflyswpiqallptylktd 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 303 ------MIPLALYF------------GKLSDKVGNKRVVQIGLLGLALCSIPAFlLIGNGHIVAMFAGIFILGFFLSVYE 364
Cdd:PRK03893 306 lgydphTVANVLFFsgfgaavgccvgGFLGDWLGTRKAYVCSLLISQLLIIPVF-AIGGANVWVLGLLLFFQQMLGQGIS 384
|
410 420
....*....|....*....|....*.
gi 501218165 365 GTLPSLLPALFFTDVRYRALSISFNI 390
Cdd:PRK03893 385 GLLPKLIGGYFDTEQRAAGLGFTYNV 410
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
46-436 |
3.20e-23 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 100.71 E-value: 3.20e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 46 LAVILSQLFFS-------------GVDNSGLQLVLT-FGTFAAAFLVrpiggiFFGRIGDKYGRKIVLSTTIILMALSTL 111
Cdd:cd17321 3 LAVFLAALDVTivnvalptiardlGASPSQLQWVVNaYLLAFAALLL------LAGRLGDRFGRKRVFLIGLALFGLASL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 112 FIALLPTyeqigvwaPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKR----GILGSGLEIGTLSGYIAASVIVTILt 187
Cdd:cd17321 77 LCALAPS--------LAFLIAARALQGIGAAAIMPASLALIAATFPGERRgralGLWGAVVGIGAALGPLLGGLLLELF- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 188 llltdeqmlswGWRIPFLIAAPIGLVGLYLRRHldespifqemekaqeesedneqfsfmdilkyhkkdFLLSTVIVAFFN 267
Cdd:cd17321 148 -----------GWRWIFLINVPIGLVALLLART-----------------------------------FSGAVLAAFLLG 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 268 ITNYMILSYIPSYLTQVLKVKET-TGLLII--SITMALMIPLAlyfGKLSDKVGNKRVVQIGLLGLALCSIPAFLLIGNG 344
Cdd:cd17321 182 AALGGLLFLLPLYLQGVLGYSPLqAGLALLplALAMLVAAPLA---GRLADRFGPRLVLVAGLLLTAVGLLLLALLGADS 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 345 HIVAMFAGIFILGFFLSVYEGTLPSLL------------PALFFTdVRYRALSISFNISVSIFGGTTPLVCSYLVHATGN 412
Cdd:cd17321 259 SVWLLLPGLVLLGLGLGLFATPLTNAAlssvpkekagaaSGILNT-ARQLGGALGVALLGALLTAGLSANLGDSGVAALL 337
|
410 420
....*....|....*....|....
gi 501218165 413 PLAPAFYLTGVSVIGLIVFSVLFV 436
Cdd:cd17321 338 SAAAAAFAAGFHLAFLVAAALALL 361
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
18-435 |
2.57e-22 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 98.39 E-value: 2.57e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 18 NSKQAKKAVIATGIGNAMEWFDFGLYAYLAVILSQLFfsGVDNSGLQLVLTFGTFAAAflvrpIGGIFFGRIGDKYGRKI 97
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAF--GLSDAQAGLLLFAFFLGYL-----LASLPAGRLIDRFGYKR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 98 VLSTTIILMALSTLFIALLPTYeqigvwapILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILgSGLEIGTLSGYI 177
Cdd:COG0738 75 GLLLGLLLMALGLLLFALAPSY--------PLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRL-NLLHAFFSLGAL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 178 AASVIVTILTLLLtdeqmLSWGWRIPFLIAA--PIGLVGLYLRRHLDESpifqemeKAQEESEDNEQFSFMDILKYhkKD 255
Cdd:COG0738 146 LGPLLGGLLILLG-----LSLSWHLPYLILAvlLLLLALLFLRSKLPEI-------EEEEEEAAGSAASLKSLLKN--PR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 256 FLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLALCSI 335
Cdd:COG0738 212 LLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 336 pafLLIGNGHIVAMFAGIFILGFFLSVyegTLPSLLPALFFTDVRYRALSISFNISVSIFGGTT-PLVCSYLVHATGnpL 414
Cdd:COG0738 292 ---LALLAPGPWLALIGLALVGLGLSL---MFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIgPPLIGFLADAFG--L 363
|
410 420
....*....|....*....|.
gi 501218165 415 APAFYLTGVSVIGLIVFSVLF 435
Cdd:COG0738 364 RAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
81-431 |
1.05e-21 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 96.46 E-value: 1.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 81 IGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEqigvwapiLLLIARMIQGFSTGGEYSGAMVYIAESSPDKK 160
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 161 R----GILGSGLEIGTLSGYIAASVIvtiltllltdeqMLSWGWRIPFLIAAPIGLVG-LYLRRHLDESPifqemekAQE 235
Cdd:cd17324 121 RgraiGLVFSGLTLGLVLGRPLGGLL------------GQLLGWRAAFLAIAVLALLAaLLLWRLLPSLP-------PKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 236 ESEDNEQFSFMDILKyhKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSD 315
Cdd:cd17324 182 PGSLGLLSSLLLLLR--NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 316 KVGNKRVVQIGLLGLALCsipAFLLIGNGHIVAMFAGIFILGFFLsvyeGTLPSLLPALFF---TDVRYRALSI---SFN 389
Cdd:cd17324 260 RGGRRALLIALLLLAAAL---LLLTLLGPSPLLLLVGLVLWGLGF----FAAHSALQTRVLrlaPEARGLASSLylaAYN 332
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 501218165 390 ISVSIFGgttpLVCSYLVHATGNPLAPAFyLTGVSVIGLIVF 431
Cdd:cd17324 333 LGGALGA----ALGGLVLDHGGWAGVGWV-GAALLLLALLLA 369
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
12-407 |
1.43e-21 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 96.27 E-value: 1.43e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 12 QDVNIVNSKQaKKAVIATGIGNAMEWFDFGLYAYLAVILSQLFfsGVDNSGLQLVLTFGTFAAAFlvrpiGGIFFGRIGD 91
Cdd:TIGR00895 6 IRKQPLSRYQ-WRAIILSFLIMLMDGYDLAAMGFAAPAISAEW--GLDPVQLGFLFSAGLIGMAF-----GALFFGPLAD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 92 KYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLIARMIQGFSTGGEYSGAMVYIAESSPDKKR----GILGSG 167
Cdd:TIGR00895 78 RIGRRRVLLWSILLFSVFTLLCALATNVTQ--------LLILRFLAGLGLGGLMPNLNALVSEYAPKRFRgtavGLMFCG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 168 LEIGTLSGYIAASVIVTILtllltdeqmlswGWRIPFLIAAPIGLV-GLYLRRHLDESPIFQEMEK-------------- 232
Cdd:TIGR00895 150 YPIGAAVGGFLAGWLIPVF------------GWRSLFYVGGIAPLLlLLLLMRFLPESIDFLVSKRpetvrrivnaiapq 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 233 --AQEESEDNEQFSFMDILKYHKK-----DFLLSTVIV----AFFNITNYMILSYIPsYLTQVLKVKETTGLLIISITMA 301
Cdd:TIGR00895 218 mqAEAQSALPEQKSTQGTKRSVFKalfqgKTARITVLLwllyFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNF 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 302 LMIPLALYFGKLSDKVGnKRVVQIGLLGLALCSIPAFLLIGNGHIVAMFagIFILGFFLSVYEGTLPSLLPALFFTDVRY 381
Cdd:TIGR00895 297 GGVIGSIIFGWLADRLG-PRVTALLLLLGAVFAVLVGSTLFSPTLLLLL--GAIAGFFVNGGQSGLYALMALFYPTAIRA 373
|
410 420
....*....|....*....|....*...
gi 501218165 382 RALSISFNIS--VSIFGgttPLVCSYLV 407
Cdd:TIGR00895 374 TGVGWAIGIGrlGAIIG---PILAGYLL 398
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
72-431 |
2.42e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 95.57 E-value: 2.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 72 FAAAFLVRPIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLIARMIQGFSTGGEYSGAMVY 151
Cdd:cd06174 37 FALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF--------WLLLLGRFLLGLGSGLIDPAVLAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 152 IAESSPDKKRGILGSGLEIGTLSGYIAASVIVTILTLlltdeqMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFQEME 231
Cdd:cd06174 109 IADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS------SLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 232 KAQEESEDNEQFSFMDILKYhkKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFG 311
Cdd:cd06174 183 KNEEASSKSVLKLLKRVLKN--PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 312 KLSDKVGNKRVVQ-IGLLGLALCSIPAFLLIGNGHIVAMFAGIFILGFFLSvyegTLPSLLPALFFTDVRYRALSISFNI 390
Cdd:cd06174 261 LLSDRLIGRKPLLlIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLL----PLSFALIAELFPPEIRGTAFGLLNT 336
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 501218165 391 SVSIFGGTTPLVCSYLVHATGNPLAPAFYLTGVSVIGLIVF 431
Cdd:cd06174 337 FGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
24-436 |
2.89e-21 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 96.12 E-value: 2.89e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 24 KAVIATGIGN-AMEWFDFGLYAYLAVILSQLFfsGVDNSGLQLVLTFGTFAAAFlVRPIGGIFFGRIGDKYG-RKIVLST 101
Cdd:COG2211 10 KEKLAYGLGDlGLNLAFGLLSAYLLYFYTDVL--GLSAALVGLILLVARLWDAI-TDPLIGALSDRTRTRWGrRRPWILI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 102 TIILMALSTLFIALLPTYEQIG--VWAPILLLIARMIqgfstggeYSGAMV----YIAESSPD-KKRGILGSGLEIGTLS 174
Cdd:COG2211 87 GAIPLALSFVLLFTAPDLSPTGklIYALVTYLLLGLA--------YTLVNIpysaLGAELTPDyEERTRLSSWRFAFAGL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 175 GYIAASVIVTILTLLLTDEQmlSWGWRIPFLIAAPIGLVGLYLrrhldesPIFQEMEKAQEEsedNEQFSFMDILKY--H 252
Cdd:COG2211 159 GGLLASVLPPPLVAAFGGDA--ALGYRLTALIFAVLGLLAFLL-------TFFGTKERPVPE---EEKVSLKESLKAllK 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 253 KKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLAL 332
Cdd:COG2211 227 NRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 333 CSIpAFLLIGNGHIVAMFAGIFILGFFLSVYEGTLPSLLP-----ALFFTDVRYRALSIS-FNISVSIFGGTTPLVCSYL 406
Cdd:COG2211 307 GLL-LLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLAdvvdyDEWKTGRRREGLYFGiFTFAIKLGQALAGALAGLL 385
|
410 420 430
....*....|....*....|....*....|...
gi 501218165 407 VHATG---NPLAPAFYLTGVSVIGLIVFSVLFV 436
Cdd:COG2211 386 LALFGyvaGAAQSPSALTGIRLLFFLLPAVLLL 418
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
57-435 |
4.13e-19 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 88.78 E-value: 4.13e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 57 GVDNSGLQLVLTFGTFAAAFLvrpigGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEqigvwapiLLLIARMI 136
Cdd:cd17474 30 GASPAQVGLLITAFTLPAAVL-----MPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA--------LLLAGRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 137 QGFSTGGEYSGAMVYIAESSPDKKR----GILGSGLEIGTLSGYIAASVIVtiltllltdeqmlSWGWRIPFLIAAPIGL 212
Cdd:cd17474 97 QGIGAAGLGPLALTLIGDLFEGGERakamGLYEAALGLGIAVGPLLGGLLA-------------AISWRYPFFLLAALIP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 213 VGLYLRRHLDEspifqemEKAQEESEDNEQFSFMDILKYHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTG 292
Cdd:cd17474 164 VAFLAILFLLP-------EPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIII 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 293 LLIISITMALMIPLALYFGKLSDK-VGNKRVVQIGLLGLALcsipAFLLIGNGH-IVAMFAGIFILGFFLSVYEGTLPSL 370
Cdd:cd17474 237 GLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYAL----SLLLLGFVPsLALLLIAIVLFGLGLGLNLPLLTTL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501218165 371 LPALFFTDvrYRALSISFNISVSIFGGTT-PLVCSYLVHATGnplAPAFYLTGvSVIGLIVFSVLF 435
Cdd:cd17474 313 VTELAPEE--ERGTASSLYNFVRFLGQAVgPLLFGLLLEIFG---LSAPFLVG-AAIALAAAVLLA 372
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
64-430 |
3.56e-16 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 79.92 E-value: 3.56e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 64 QLVLTFGTFAAAFLvrpIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALlptyeqigVWAPILLLIARMIQGFSTGG 143
Cdd:cd17319 39 QYGLIASAFFLGYA---LFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF--------ATSLTSLYVLRFLLGVAEAG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 144 EYSGAMVYIAESSPDKKRGiLGSGLeigTLSGYIAASVIVTILTLLLtdeqMLSWGWRIPFLIAAPIGLVglylrrhlde 223
Cdd:cd17319 108 FFPGAIKALAEWFPARERG-RATGL---FNSGAPLGAAIGPPLSGWL----LLLFGWRWAFIIEGLLGLL---------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 224 spifqemekaqeesedneqFSFMDILKYhkKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALM 303
Cdd:cd17319 170 -------------------LAVLWWFYL--RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 304 IPLALYFGKLSDKVGNKRVVQIGLLGLALCSIPAFLLIGNGHIVAMFAGIFILGFFLSVYEGTLPSLLPALFftDVRYRA 383
Cdd:cd17319 229 AIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLL--PGEAAA 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 501218165 384 LSISFNISVSIFGG-TTPLVCSYLVHATGNPLAPAFYLTGVSVIGLIV 430
Cdd:cd17319 307 TAGGLINSGGNLGGfVAPLLIGYLVDATGSYTAAFLFLAAVALLAALL 354
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
23-406 |
5.12e-16 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 79.97 E-value: 5.12e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 23 KKAVIATGIGNAMEWFDFGLYAYLAVILsqlffsgvdNSGLQLVLTFGTF--AAAFLVRPIGGIFFGRIGDKYGRKIVLS 100
Cdd:PRK12307 17 KNALFSAWLGYVFDGFDFMLIFYIMYLI---------KADLGLTDMEGAFlaTAAFIGRPFGGALFGLLADKFGRKPLMM 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 101 TTIILMALSTLFIALLPTYeqigvwapILLLIARMIQGFSTGGEYSGAMVYIAESSP----DKKRGILGSGLEIGTLsgy 176
Cdd:PRK12307 88 WSIVAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPkhlkSKASAFLVSGFGIGNI--- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 177 IAASVIVTILTllltdeqmlSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFQEME---KAQEESEDNEQFSFMDILKYHK 253
Cdd:PRK12307 157 IAAYFMPSFAE---------AYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKlsgKGKHSQSAWSVFSLSMKGLFNR 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 254 KDFLLS-TVIVAFFNI--TNYMILSYIPSYLTQvlkvkETTGLLIISITMAL----MIPLALYFGKLSDKVGNKRVVQIG 326
Cdd:PRK12307 228 AQFPLTlCVFIVLFSIfgANWPIFGLLPTYLAG-----EGFDTGVVSNLMTAaafgTVLGNIVWGLCADRIGLKKTFSIG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 327 LLGLALCSIPAFlLIGNGHIVAMFAGIFILGFFLSVYEGTLPSLLPALFFTDVRYRALSISFNISVSifGGT-TPLVCSY 405
Cdd:PRK12307 303 LLMSFLFIFPLF-RIPQDNYLLLGACLFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAAT--SGTfNSMAATW 379
|
.
gi 501218165 406 L 406
Cdd:PRK12307 380 L 380
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
26-221 |
3.51e-15 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 76.93 E-value: 3.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 26 VIATGIGNAMEWFDFGLYAYLAVILSQLFFS--GVDNSGLQLVLTFGTFAAAFlvrpIGGIFFGRIGDKYGRKIVLSTTI 103
Cdd:cd17364 1 IIIAGMGFFTDAYDLFSISLVTKILGRLYYGgkGSLPSGVSGLVNAAALVGTI----IGQLFFGFLGDRFGRKRVYGVEL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 104 ILMALSTLFIALLPTYEQIGVWApiLLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGIL----GSGLEIGTLSGYIAA 179
Cdd:cd17364 77 IIMIIGTILSALSPGSTPLGVMG--WLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALiaavFAMQGFGILAGAIVT 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 501218165 180 SVIVTIL--TLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHL 221
Cdd:cd17364 155 LILSAIFehPLPAGTYHHADLVWRIVLGLGAIPALSVLYFRKHL 198
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
71-436 |
4.71e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 76.48 E-value: 4.71e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 71 TFAAAFLVRPiggiFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTyeqigvwaPILLLIARMIQGFSTGGEYSGAMV 150
Cdd:cd17489 40 FTLAALLARP----FAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS--------VALLLVLRLIHGIGWGAFTTAAAT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 151 YIAESSPDKKRgilGSGLEIGTLSGYIAAsVIVTILTLLLTDEqmlsWGWRIPFLIAAPIGLVGLYLRRHLDESPIfqem 230
Cdd:cd17489 108 LVADIIPPSRR---GEGIGYYGLATTLAM-ALGPALGLFLYQH----LGFAVLFIVAAVLALLALLLVFLVKDPPP---- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 231 ekAQEESEDNEQFSFMDILkyhKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLalyF 310
Cdd:cd17489 176 --VAAEEAEAGTRAFRRLV---EKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAIALLLSRPF---S 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 311 GKLSDKVGNKRVVQIGLLGLALcsipAFLLIGNGHIVAMFagiFILGFFLSVYEGTLPSLLPALFFTDV----RYRALSI 386
Cdd:cd17489 248 GKLSDRKGPKTVIIPGLLLLAL----GLLLLSFAGSPWML---LLAAVLYGLGFGLLFPALQALAVDLVpphrRGAANGT 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 501218165 387 sFNISVSIFGGTTPLVCSYLVHATGnpLAPAFYLTGVSVIGLIVFSVLFV 436
Cdd:cd17489 321 -FFIFFDLGIGLGGLLLGLVAELFG--YRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
46-435 |
6.79e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 76.07 E-value: 6.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 46 LAVILSQLFFSGVDNSGL--QLVLTFGTFAAAflvrpIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEqig 123
Cdd:cd17473 18 IAPALPAIAQHFVPNSELlvPLLLTLPALFIA-----LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLY--- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 124 vwapiLLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRgilgsgleiGTLSGYIAASVIVTILTLLLTDEQMLSWGWRIP 203
Cdd:cd17473 90 -----ALLASRALLGIGVAGIMTLATALIGDYFEGEER---------AKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 204 FLI---AAPIG-LVGLYLRrhldespifqemEKAQEESEDNEQFSFMdILKYHKKDFLLSTVIVAFFNITNYMILSYIPS 279
Cdd:cd17473 156 FLVyllALPVLiLVLLFLP------------EPARKSKSAASPGAAT-AAALPWKRVLPIYFLAFLAMLLFYVIPIQLPF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 280 YLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLALcsipAFLLIG-NGHIVAMFAGIFILGF 358
Cdd:cd17473 223 LLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL----GFLLLAlASGLWVVLLGAILAGL 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501218165 359 FLSVYEGTLPSLLPALFFTDVRYRALSIsfnISVSIFGG--TTPLVCSYLVHATGNPLApAFYLTGVSVIGLIVFSVLF 435
Cdd:cd17473 299 GFGLLLPTLNSWAMSLVPPELRGRAMGI---VTSAFFLGqfLSPLVLGPLVNLTGGLSG-AFLILGVLALVLAIVLLLL 373
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
67-336 |
2.35e-14 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 74.61 E-value: 2.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 67 LTFG-TFAAAFLVRPIGGiffgRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLIARMIQGFSTgGEY 145
Cdd:cd17391 40 LAFSsTFLVSAIFSPIWG----RLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQ--------LLILRLLQGVFS-GYV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 146 SGAMVYIAESSPDKKrgilgSGLEIGTLS-GYIAASVIVTILTLLLTDeqmlSWGWRIPFLIAAPIGLVGLYLrrhldes 224
Cdd:cd17391 107 PNATALIASQTPKEK-----SGWALGTLStGVVAGTLIGPLLGGFLAD----LFGIRNVFFITGGLLFLAFLL------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 225 PIFQEMEKAQEESEDnEQFSFMDILKYHKKDFLLSTVIVAFF--NITNYMILSYIPSY---LTQVLKVKETTGLLIISIT 299
Cdd:cd17391 171 TLFFVKEDFKPVEKK-KMVSTKEVWNSVPNPSLLISLFVTTFiiQLANQSIEPILTLYirqLMGDASNLAFISGLVFSAT 249
|
250 260 270
....*....|....*....|....*....|....*..
gi 501218165 300 MALMIPLALYFGKLSDKVGNKRVVQIGLLGLALCSIP 336
Cdd:cd17391 250 GVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIP 286
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
89-361 |
6.81e-14 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 72.99 E-value: 6.81e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 89 IGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGilgSGL 168
Cdd:cd17503 54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRG---AAM 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 169 EIGTLSGyIAASVIVTILTLLLTDeqmlSWGWRIPFLIAAPIGLVGLYLrrhldeSPIFQemekaqeesedneqfsfMDI 248
Cdd:cd17503 123 GLVGLVI-LLAPAIGPTLGGWLTD----NLSWRWIFYINLPIGILALLL------APLLD-----------------LRL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 249 LKYhkKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVK-ETTGLLII--SITMALMIPLAlyfGKLSDKVGNKRVVQI 325
Cdd:cd17503 175 FKD--RNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSaFESGLVLApgGLASAILSPLV---GRLLDKFGPRLLLLA 249
|
250 260 270
....*....|....*....|....*....|....*.
gi 501218165 326 GLLGLALCSIPAFLLIGNGHIVAMFAGIFILGFFLS 361
Cdd:cd17503 250 GLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMG 285
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
70-436 |
2.16e-13 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 71.45 E-value: 2.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 70 GTFAAAFLV-RPIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLIARMIQGFSTGGEYSGA 148
Cdd:cd17315 37 GLVVSSLLLgAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV--------LIVGRFLLGLGVGLASVLV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 149 MVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTILtllltdEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIfq 228
Cdd:cd17315 109 PLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLAL------SLSPPGWWRLMFALAAVPALLQLLLMFFLPESRA-- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 229 emekaqeesedneqfsfmdilkyhkkdFLLSTVIVAFFNIT--NyMILSYIPSYLTQVLkvKETTGLLIISITMALMIPL 306
Cdd:cd17315 181 ---------------------------LLVGVGLQLLQQLTgiN-AVMYYAPTIFKSAG--GGTASILASIIVGVVNLLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 307 ALYFGKLSDKVGNKRVVQIGLLGLALCSIP---AFLLIGNGHIVAMFAGIFILGFFL--SVYEGTLPSLL-PALFFTDVR 380
Cdd:cd17315 231 TLVAIRLVDKVGRRPLLLIGFAGMAASLLLlaiAFLLPALAKAAGWLALLGILLYIAafAMGAGPVPWLLlSEIFPLRIR 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 501218165 381 YRALSISFN---ISVSIFGGTTPLVCSYLvhatGNPLAPAFYlTGVSVIGLiVFSVLFV 436
Cdd:cd17315 311 GKGMAIATLvnwIFNFIVGLTFLIMVSTI----GLAGVFIFF-AAVCLLAL-VFVFFFV 363
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
64-436 |
5.06e-13 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 70.75 E-value: 5.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 64 QLVLTFGTFAAAFLVRPIGGIFFGR-IGDKYGRKIVLSTTIILMALSTLFIALlptyeQIGVWAPILLLIARMIQGFSTG 142
Cdd:cd17357 46 ELDLLWSLIVSIFFIGGAIGSFISAfLANRFGRKNGLLISNALLVVSSLLMFL-----SKSAKSPELLIFGRFLVGIACG 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 143 GEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVtiLTLLLTDEQmlswGWRIPFLIAAPIGLVGLYLRRHLD 222
Cdd:cd17357 121 LSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFG--LPSVLGTET----LWPYLLFFPGIPALLQLAALPFFP 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 223 ESPIF-----------------------------QEMEKAQEESEDNEQFSFMDILK---YHKKdfLLSTVIVAFFNITN 270
Cdd:cd17357 195 ESPKFlliskgdeeeaekslkflrgieddvdqelEEIKKESEQMGDQKQVSLMQLLRdpsLRLP--LLLVLVVSASQQFS 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 271 --YMILSYIPSYLTQV-LKVKE----TTGLLIISITMALMIPLALyfgklsDKVGNKRVVQIGLLGLALC----SIPAFL 339
Cdd:cd17357 273 giNAIFFYSTFIFENAgFSPQLaewaNLGIGIVNVLSTIVGPFLI------EKVGRRPLLLISLSVCAVAlllmSVFLFL 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 340 LIGNGHIVAMFAG-IFILGFFLSVYEGTLPSLLPALFFTDvRYRALSISFnisvsifggttplvcSYLVHATGNPLAPAF 418
Cdd:cd17357 347 SEQNSWMSYGCIVaIFLFIFFFAIGLGPIPWFIGAELFPQ-APRSAAQSL---------------GSSVNWTSNFIVGMA 410
|
410
....*....|....*...
gi 501218165 419 YLTGVSVIGLIVFsVLFV 436
Cdd:cd17357 411 FPPLQSIGGGFVF-IIFA 427
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
83-431 |
5.08e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 70.73 E-value: 5.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 83 GIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLIARMIQGFSTGGEYSGAMVYIAESSPDKKR- 161
Cdd:cd17328 51 SPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ--------LLLFRALVGIGEASYSPIAPTIIADLFPKEKRt 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 162 ---GILGSGLEIGTLSGYIAASVIVTiltllltdeqmLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFQEMEKAQEESE 238
Cdd:cd17328 123 ralGVFYFAIPLGSGLGYVVGGLVAQ-----------ATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 239 DNEqfSFMDILKY--HKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETT----GLLIISITMALMIPLALYFGK 312
Cdd:cd17328 192 TAT--SFLADLKAlaKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSsadvGLIFGAITCIAGVLGVLLGGI 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 313 LSDKVGNKR------VVQIGLLGLALCSIPAFLLiGNGHIVAMFAGIFILGFFLSVYEGTLPSLLpaLFFTDVRYRALSI 386
Cdd:cd17328 270 LADRLRRKTpradplVCAVGLLAAAPFLFLALVL-ALSNLLLAWVLLFLGEFLLSLNWAPVFAIL--LYVVIPTRRSTAS 346
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 501218165 387 SFNISVS-IFGGTTP-----LVCSYLVHATGNPLAPA-------FYLTGVSVIGLIVF 431
Cdd:cd17328 347 AIQILLShLLGDAGSpyligLISDLLRQNKDSPLAEAaslqyalLLCSFVLVLGGFFF 404
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
85-439 |
1.38e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 69.14 E-value: 1.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 85 FFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEqigvwapiLLLIARMIQGFstggeySGAMVYIA-----ESSPDK 159
Cdd:cd17504 50 ILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLP--------VLIAGRALQGI------GGAVFPLAfalvrEEFPPE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 160 KR----GILGSGLEIGTLSGYIAASVIVTIltllltdeqmlsWGWRIPFLIAAPIGLVGLYLrrhldeSPIfqemekaqe 235
Cdd:cd17504 116 RVpvaqGILSATFGIGAGIGLPLGGWIVQH------------LGWRWIFWTAAPVAVLLAAL------VPL--------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 236 esedneqfsfMDILKYHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQvlkVKETTGLLIISITMALMIPLAL------- 308
Cdd:cd17504 169 ----------IDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQL---PTPTGFGLGITEAGLLLLPGALvmliagp 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 309 YFGKLSDKVGNKRVVQIGLLGLALCSipAFLLIGNGHIVAMFAGIFILGFFLSVYEGTLPSLLpaLFFTDVRYRALSISF 388
Cdd:cd17504 236 LAGRLIARVGPRRVLLIGLVISAVGL--LLLALLHSSLWALVVALLLIGIGLGLAFASLPNIV--VESVPPDRTGIATGM 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 501218165 389 NISVSIFG--------GTTPLVCSYLVHATGNPLAPAFYLTGVSVIGLIVFSVLFVTTS 439
Cdd:cd17504 312 NTVLRTIGsaigpaiaGAILTTYTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLI 370
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
57-431 |
2.61e-12 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 67.99 E-value: 2.61e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 57 GVDNSGLQLVLTfgTFAAAFLvrpIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLIARMI 136
Cdd:cd17320 30 GASASAVQLTLS--AYLLGFA---LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--------LLIARFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 137 QGFSTGGEYSGAMVYIAESSPDKKR----GILGSGLEIGTLSGYIAASVIvtiltllltdeqMLSWGWRIPFLIAAPIGL 212
Cdd:cd17320 97 QGLGAAAGSVVARAIVRDLYSGAELakifSLLMMILAIAPALAPLLGGLL------------LLFFGWRAIFVFLALLGL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 213 VGLYLRrhldespIFQEMEKAQEESEDNEQFSFMDILKYHKKD--FLLSTVIVAFFNITNYMILSYIPSYLTQVLKV-KE 289
Cdd:cd17320 165 LLLLLV-------LLFLPETLPEEKRKPLLSSLLRAYKRVLKNrrFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLsPA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 290 TTGLLIISITMALMIpLALYFGKLSDKVGNKRVVQIGLLGLALCS--IPAFLLIGNGHIVAMFAGIFILGFFLSVYEGTL 367
Cdd:cd17320 238 QFGLLFALNAIALIL-GSLLNGRLVRRFGPRRLLRLGLLLLLAAAlvLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501218165 368 PSLlpALF-FTDVRYRALSISFNISVSIFGGTTPLVcSYLVHATGNPLAPAFYLTGVSVIGLIVF 431
Cdd:cd17320 317 TSL--ALEpFPHVAGTASALLGFLQFLIGALAGALV-GLLPNGTALPMGLLILVLGLLALLLLIL 378
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
33-434 |
4.22e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 67.23 E-value: 4.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 33 NAMEWFDFGLYAYLAVILSQLFfsGVDNSGLQLVLTFGTFAAAflvrpIGGIFFGRIGDKYGRKIVLSTTIILMALSTLF 112
Cdd:cd17365 8 IVLDGFDLAVMGFVAPALAQDW--GLSPAQLGPVGSAALFGMA-----IGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 113 IALLPTYEQIGVWapillliaRMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSgleiGTLSGYIAASVIVTILTLLLTD 192
Cdd:cd17365 81 TAFAQSVLQLALL--------RFLTGLGLGAAMPNAITLVSEYAPARRRSLAVT----LMFCGYPLGAALGGFLAAALIP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 193 eqmlSWGWRIPFLIAAPIGLVGLYLrrhldespifqemekaqeesedneqfsfmdilkyhkkdfLLSTVI--VAFFN--I 268
Cdd:cd17365 149 ----AFGWRSVFLLGGVPPLILLPL---------------------------------------LRGTLLlwVTFFMglL 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 269 TNYMILSYIPSYLtqvlkvkETTGL-LIISITMALMIPL-----ALYFGKLSDKVGNKRVVQIGLLGLALCSipAFLLIG 342
Cdd:cd17365 186 LVYLLNSWLPKLM-------VEAGYsLSQALTITLLLNIggvigSLLLGWLADRFGPKRVLALFFALGAVSL--ALLGVS 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 343 NGHIVAMFAGIFILGFFLSVYEGTLPSLLPALFFTDVryRALSISFNISVSIFGGTT-PLVCSYLVHATGNPLAPAFYLT 421
Cdd:cd17365 257 PASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEV--RATGVGWALGVGRLGAILgPLLGGLLLAAGLGPESVFLALA 334
|
410
....*....|...
gi 501218165 422 GVSVIGLIVFSVL 434
Cdd:cd17365 335 IPAALGALAVLLL 347
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
25-435 |
1.27e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 66.10 E-value: 1.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 25 AVIATGIGNAMEWFDFGLYAYlavilsqlffsGVDNSGLQLVLTFGTFAAAFLvrpIGGIFFGRIGDKYGRKIVLSTTII 104
Cdd:cd06173 7 AQLLSALGDWIFTVALPWLVL-----------QLTGSALLVGLVLAAFFLPFL---LFSPFAGVLADRFDRRRLLILADL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 105 LMALSTLFIALLPTYEQIGVWAPILLLIARMIQG-FSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIV 183
Cdd:cd06173 73 LRALLAAVLALLALLGSLSLWLLLVLAFLLGIASaFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 184 TILtllltdeqmlswGWRIPFLIAAPIGLVGLYLrrhldESPIFQEMEKAQEESEDNEQFSFMDILKYHKKDFLLSTVI- 262
Cdd:cd06173 153 ALL------------GPGGAFAINALSFLLSALL-----LLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLl 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 263 -VAFFNITNYMILSYIPSYLTQVLKVKETT-GLL--IISITMALMiplALYFGKLSDKVGNKRVVQIGLLGLALCSIPAF 338
Cdd:cd06173 216 aLALFALLGGALTVLLPLLAKEVLGGGAAGyGLLlaAFGVGALLG---ALLLGRLSKRRRRGRLLLIGALLLGLALLVLG 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 339 LLignGHIVAMFAGIFILGFFLSVYEGTLPSLLPALFFTDVRYRALSIsFNISVSIFGGTTPLVCSYLVHATGnpLAPAF 418
Cdd:cd06173 293 LS---PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSV-YNALNSGAMPLGALLAGLLADALG--LSAVF 366
|
410
....*....|....*..
gi 501218165 419 YLTGVSVIGLIVFSVLF 435
Cdd:cd06173 367 LLAGALLLLAALLLLLL 383
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
81-430 |
1.45e-11 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 65.68 E-value: 1.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 81 IGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEqigvwapiLLLIARMIQGFSTGGEYSGAMVYIAESSPDKK 160
Cdd:cd17317 40 IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 161 RGILGSGLEIGTLSGYiaasVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYlrrhldespifqemekaqeesedn 240
Cdd:cd17317 112 RSFVGILFGLFWALGY----MLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWLPR------------------------ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 241 eqfsfmdilkyhkkdfllSTVIVAFFNITNYMIlsyipsYLTQVLKVKETTG-LLIISITMALMIPLALYFGKLSDKVGN 319
Cdd:cd17317 164 ------------------RTIIVGLIWFVTSLV------YYGLSLNSSNLGGnLYLNFFLSGLVEIPAYFLALLLLDRLG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 320 KRVVQIGLLGLA-LCSIPAFLLIGNGHIVAMFagIFILG-FFLSVYEGTLPSLLPALFFTDVRYRALSisfniSVSIFGG 397
Cdd:cd17317 220 RRWTLSGSLLLAgLACLVTALLPDDENTLALT--LALVGkFAISAAFSVIYLYTAELYPTVVRNTGVG-----LCSTVAR 292
|
330 340 350
....*....|....*....|....*....|....
gi 501218165 398 TTPLVCSYLVH-ATGNPLAPAFYLTGVSVIGLIV 430
Cdd:cd17317 293 VGAILAPFIVLlGKIGPLLPLIIFGVLALLGGLL 326
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
57-430 |
1.57e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 66.05 E-value: 1.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 57 GVDNSGLQLVLTFGTFAAAflvrpIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLIARMI 136
Cdd:COG2807 49 GLSATQAGLLTTLPLLAFG-----LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSV--------ALLLAGTAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 137 QGFSTGGEYSGAMVYIAESSPDKkrgilgsgleIGTLSG-YIAASVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGL 215
Cdd:COG2807 116 IGAGIAVGNVLLPGLIKRWFPDR----------VGLMTGlYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLAL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 216 YLRRhldesPIFQEMEKAQEESEDNEQFSFMdilkYHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQvLKVKETTGLLI 295
Cdd:COG2807 186 LLWL-----PLLRRRPAAAAAAPAAASLRSL----WRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 296 ISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLALCSIPAFLLIGNGHIV--AMFAGIFILGFFlsvyegTLPSLLPA 373
Cdd:COG2807 256 LSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWlwAVLLGLGQGGLF------PLALTLIG 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 501218165 374 LFFTDVRYRALSISFNISVS-IFGGTTPLVCSYLVHATGNPLAPAFYLTGVSVIGLIV 430
Cdd:COG2807 330 LRARTPAEAAALSGMAQSVGyLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
85-361 |
2.02e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 65.27 E-value: 2.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 85 FFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKrgil 164
Cdd:cd17478 50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNY--------WLLLLLVALAGIGSAAFHPEGARLASQAAGGRR---- 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 165 GSGLEIGTLSGYIAASVIVTILTLLLTdeqmlSWGWRIPFLIAAPIGLVGLYLRRHLDESpifqemeKAQEESEDNEQFS 244
Cdd:cd17478 118 GLAMSIFSVGGNLGFALGPLIAAALVA-----LFGGLGLLILLIIPGLAVALLLLRLRPL-------KKPEAKKAAAKSS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 245 FMDILKYHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPlALYFGKLSDKVGNKRVVQ 324
Cdd:cd17478 186 ARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIG-TLIGGPLSDRFGRRRVII 264
|
250 260 270
....*....|....*....|....*....|....*..
gi 501218165 325 IGLLGlalcSIPAFLLIGNGHIVAMFAGIFILGFFLS 361
Cdd:cd17478 265 ASLLL----AAPFLLLFLLTPGIWSYILLVLAGFLLF 297
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
81-387 |
2.07e-11 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 65.28 E-value: 2.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 81 IGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLIARMIQGFSTGGEYSGAMVYIAESSPDKK 160
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNF--------TIFIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 161 RGILGSGLEIGTLSGYIAASVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFqemekaqeesedn 240
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRW------------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 241 eqfsfmdiLKYHKKDFLLSTVIVAFFN--ITNYMILSYIPSYLTQVlKVKETTGLL---IISITMALMIPLALYfgkLSD 315
Cdd:cd17359 190 --------LVSKGKPILIIGIGLAIFQqfVGINVIFYYGPEIFQNA-GFSENAALLqtiGIGVVNVIFTIIAIL---LVD 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 316 KVGNKRVVQIGLLG----LALCSIpAFLLIGNGHIVAMFAGIFILgFFLSVYEGTLPS----LLPALFFTDVRYRALSIS 387
Cdd:cd17359 258 KVGRKPLLLIGSIGmaisLLLIGT-AFYFAPGSQASGIVALVLIL-LFVAFFAMSWGPvtwvLLSEIFPNRIRGLAMGIA 335
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
57-430 |
5.19e-10 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 61.13 E-value: 5.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 57 GVDNSGLQLVLTFGTFAAAflvrpIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapiLLLIARMI 136
Cdd:cd17355 34 GWSRAVISLAFTVGLLAFG-----LAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQ-------LYLLWGLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 137 QGFSTGGEYSGAMVYIAESSPDKKRGIlgsGLEIGTLSGYIAASVIVTILTLLLTDeqmlsWGWRIPFLIAAPIGL---- 212
Cdd:cd17355 102 GGGGAGTLAAVAFATVAAWWFERRRGL---ALGILTAGGGLGSLVFLPLGAALIEA-----FGWRTALLVLALLALlvlv 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 213 -VGLYLRRHLdespifqeMEKAQEESEDNEQFSFMDILKYHKKD--FLLSTVIVAFFNITNYMILSYIPSYLTQvLKVKE 289
Cdd:cd17355 174 pVLLLLRRRP--------ADLALRAYDDASPASPGSTLKEALRSasFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 290 TTGLLIISITMALMIPLALYFGKLSDKVGNKRVVqIGLLGLALCSIPAFLLIGNGHIVAMFAGIFILGFFLSvyEGTLPS 369
Cdd:cd17355 245 AAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLL-AASYALRALGLALLLLLPFPPLALLLFAALFGLGWGA--TVPLTA 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501218165 370 LLPALFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHATGNpLAPAFYLTGVSVIGLIV 430
Cdd:cd17355 322 ALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGS-YTAAWALAVALGLIAAL 381
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
74-432 |
5.28e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 61.10 E-value: 5.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 74 AAFLVRPIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQIGVWapiLLLIarmiqGFSTGGEYSGAMVYIA 153
Cdd:cd17475 39 ALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVL---LFLV-----GAGYGSVQPGGGRAIM 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 154 ESSPDKKRG----ILGSGLEIGtlsGYIAASVIVTIltllltdeqMLSWGWRIPFLIAAPIGLV-GLYLRRHLDESPIFq 228
Cdd:cd17475 111 RWFPPRERGlamgIRQTGVPLG---GALAAALLPPL---------ALHYGWRAAFVVAGLVSILaAVLFWLFYREPPAA- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 229 emeKAQEESEDNEQFSFMDILKYhkKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLAL 308
Cdd:cd17475 178 ---SAATESASTLLRSLKEVLRN--RDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 309 YFGKLSDKV--GNKRVVQIGLLGLALCSIPAFLLIGNG-HIVAMFAGIFILGFFLSVYEGtlPSLLPALFFTDVRYRALS 385
Cdd:cd17475 253 GLGRVSDRVfgGRRRPVLVITAAIAAAALLVLSLLSPGtPLWLLVLLLILLGLFAIGWNG--LYLTLVAESAGPEQAGTA 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 501218165 386 ISFNISVSIFG-GTTPLVCSYLVHATGNPLAPAFYLTGVSVIGLIVFS 432
Cdd:cd17475 331 LGLANTINFIGiAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
41-431 |
5.93e-10 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 61.02 E-value: 5.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 41 GLYAYLAVILSQLffsGVDNSGLQLVLTFGTFAAAFLvrpigGIFFGRIGDKYG-RKIVLSTTIILMALSTLFIALLPTY 119
Cdd:cd17370 17 MARSILPLFLVVL---GASAAAVGLIEGLAEALGSLL-----RLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 120 EqigvWAPILLLIARMIQGFSTggeySGAMVYIAESSPDKKR----GILGSGLEIGTLSGYIAASVIVTILtllltdeqm 195
Cdd:cd17370 89 Q----LVLLLRILERLGKGIRT----PPRDALLADATPPSGRgkafGLHRALDTLGAVLGPLLAALLLYLL--------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 196 lSWGWRIPFLIAAPIGLVGLYLrrhldespIFQEMEKAQEESEDNEQFSFMDILKYhKKDFLLSTVIVAFFNITNYmilS 275
Cdd:cd17370 152 -GGNYRTIFLLAAIPALLALLI--------LLFVVKEYPRPPKLRKKSKKTSLKKL-PKAFWLYLLAVALFALGNF---S 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 276 YI-PSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLALCSipaFLLIGNGHIVAMFAGIF 354
Cdd:cd17370 219 FAfLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAY---LGFALGSSLWLLLLGFI 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501218165 355 ILGFFLSVYEGTLPSLLPALFFTDVRYRALSIsFNISVSIFGGTTPLVCSYLVHATGnPLAPAFYLTGVSVIGLIVF 431
Cdd:cd17370 296 LWGLYMGAQESIERAAVADLVPAELRGTAYGL-FNTVVGIGWLLASLIAGYLWDLIS-PSAAFLFSAVLALIALLLL 370
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
85-358 |
1.09e-09 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 59.88 E-value: 1.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 85 FFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGIL 164
Cdd:cd17502 49 IYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTM--------LIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 165 gsgleIGTLSG-YIAASVIVTILTLLLTDeqmlSWGWRIPFLIAAPIGLVGLYLRRhldespifqemekaqeesedneqf 243
Cdd:cd17502 121 -----QGYIGAvFGIASVAGPLIGGAFTD----HLSWRWCFYINLPIGGLALALLR------------------------ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 244 sfmdilkyhkkDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKET-TGLLIISITMALMIpLALYFGKLSDKVGN-KR 321
Cdd:cd17502 168 -----------TILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATkSGVRLLPLIIGLVI-GSIISGALISKTGRyKP 235
|
250 260 270
....*....|....*....|....*....|....*..
gi 501218165 322 VVQIGLLGLALCSIPAFLLIGNGHIVAMFAGIFILGF 358
Cdd:cd17502 236 LIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGL 272
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
80-443 |
1.27e-09 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 60.28 E-value: 1.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 80 PIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLIARMIQGFSTGGEYSGAMVYIAESSPDK 159
Cdd:cd17358 55 LIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWM--------LYLGRFLAGFGGGAASVVVPVYIAEIAPKN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 160 KRGILGSGLE----IGTLSGYIAASVI----VTILTLLLTDEQMLSwgwrIPFLIAAPIGLVG-----------LYLR-R 219
Cdd:cd17358 127 VRGALGSLNQllvnIGILLGYVLGSFLpwrtLALIGAIPPVVFLIL----LFFIPESPRWLAKkgreeeaekslQFLRgK 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 220 HLDESPIFQEMEKAQEESEDNEQFSFMDILKYHK--KDFLLSTVIVAF------FNITNYMilSYIPSYLTQVLKVKetT 291
Cdd:cd17358 203 DADISKEAAEIQEELAELEKEAKESSFSDLFQRKylKPLVIGLGLMLFqqlsgiNAVIFYA--SSIFDEAGSGLDPN--T 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 292 GLLIISITMALMIPLALYfgkLSDKVGNKRVVQIGLLGLALCSIP---AFLLIGNGH-----------IVAMFAGIFILG 357
Cdd:cd17358 279 ATIIIGVVQVVGTLVATL---LVDRLGRRPLLLVSAIGMGIGLLAlglYFYLQEHGAllssvswlplvGLVIYIISFSIG 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 358 FflsvyeGTLPSLLPA-LFFTDVRYRALSI---SFNISVSIFGGTTPLVCSYLvhatgnPLAPAFYLTGVSVIGLIVFSV 433
Cdd:cd17358 356 L------GPLPWVIMSeIFPAKIKGLAGSLvtlVNWLFAFIVTKTFPFLTLAW------GASGTFWIFAGICGLALVFVL 423
|
410
....*....|.
gi 501218165 434 LFV-TTSGRAL 443
Cdd:cd17358 424 LFVpETKGKSL 434
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
246-446 |
3.24e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.45 E-value: 3.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 246 MDILKYHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQI 325
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 326 GLLGLALCSIPAFLLignGHIVAMFAGIFILGFFLSVYEGTLPSLLPALFftDVRYRALSISFNISVSIFGGTT-PLVCS 404
Cdd:COG2814 81 GLLLFALGSLLCALA---PSLWLLLAARFLQGLGAGALFPAALALIADLV--PPERRGRALGLLGAGLGLGPALgPLLGG 155
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 501218165 405 YLVHATGnpLAPAFYLTGVSVIGLIVFSVLFVTTSGRALKGS 446
Cdd:COG2814 156 LLADLFG--WRWVFLVNAVLALLALLLLLRLLPESRPAARAR 195
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
82-380 |
4.88e-09 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 58.05 E-value: 4.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 82 GGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLIARMIQGFSTGGEYSGAMVYIAESSPDKKR 161
Cdd:PRK11551 66 GALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--------LLVARLLTGVGLGGALPNLIALTSEAVGPRLR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 162 G----ILGSGLEIGtlsGYIAAsvivtILTLLLTDEQmlswGWRIPFLI--AAPIGLVGLyLRRHLDESPIFQEMEKAQE 235
Cdd:PRK11551 138 GtavsLMYCGVPFG---GALAS-----VIGVLAAGDA----AWRHIFYVggVGPLLLVPL-LMRWLPESRAFAQAAGAGK 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 236 ESEdneqfSFMDILkyHKKDFLLSTVI--VAFFN--ITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPlALYFG 311
Cdd:PRK11551 205 QRA-----PVLRAL--FGEGRATATLLlwISYFFtlIVLYFLLNWLPSLLVGQGLSRSQAGLVQIAFNIGGALG-SLLIG 276
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 312 KLSDKVGNKRVVqiglLGLALCSIPAFLLIGNGH-IVAMFAGIFILGFFLSVYEGTLPSLLPALFFTDVR 380
Cdd:PRK11551 277 ALMDRLRPRRVV----LLIYAGILASLAALAAAPsFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPTQVR 342
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
25-431 |
8.37e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 57.18 E-value: 8.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 25 AVIATGIGNAMewfdfgLYAYLAVILSQlffSGVDNSGLQLVLTFgtFAAAFLvrpIGGIFFGRIGDKYGRKIVLSTTII 104
Cdd:cd17477 4 SVALLGLGSGL------LLPLLSLRLER---EGVSTALIGLVASA--YYLGIL---LGSPLVPRLIRRVGHIRAFAAGAA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 105 LMALSTLFIALLPTyeqigvwaPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVT 184
Cdd:cd17477 70 ITAVSVLLLALTDS--------PWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 185 ILTLLltdeqmlswGWRiPFLIAAPI---GLVGLYLRRHldespifqemekAQEESEDNEQFSFMDILKYHKkdflLSTV 261
Cdd:cd17477 142 LVGTA---------GAL-PFLIAAVLlllALVPLLLTRR------------AAPEIEEAESISLRRLLRIAP----LALL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 262 IVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIpLALYFGKLSDKVGNKRVvqigLLGLALCSIPAFLLI 341
Cdd:cd17477 196 GAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLL-LQWPLGWLADRFDRRRV----LLGCALLGALAALLL 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 342 G--NGHIVAMFAGIFILGFFLsvyeGTLPSLLPAL---FFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHATGnPLAP 416
Cdd:cd17477 271 PlvPGLPLALLVLLFLWGGAA----GPLYTLALALagdRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFG-PHGL 345
|
410
....*....|....*
gi 501218165 417 AFYLTGVSVIGLIVF 431
Cdd:cd17477 346 FLFLAAVALLFLLFL 360
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
24-245 |
8.65e-09 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 57.82 E-value: 8.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 24 KAVIATGIGNAMEWFDFGLYAYLAVILSQLFF--SGVDNSGLQLVLTfgtfAAAFLVRPIGGIFFGRIGDKYGRKIVLST 101
Cdd:TIGR00887 16 RAIVIAGVGFFTDSYDLFCISLVTKMLGYVYYhgKGPLPSSVSAAVN----GSASIGTLAGQLFFGWLADKLGRKRVYGM 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 102 TIILMALSTLFIALLPTYEQIGVWApiLLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGL----EIGTLSGYI 177
Cdd:TIGR00887 92 ELIIMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAVfamqGFGILAGAI 169
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501218165 178 AASVIVTILTLLLTDEQMLS-----------WGWRIPFLIAAPIGLVGLYLRRHLDESPIFQEMEKAQEESEDNEQFSF 245
Cdd:TIGR00887 170 VALIVLAGFKHSLEAAADEAsctgscvpavdYMWRILIGFGAVPALLALYFRLTIPETPRYTADVAKDVEQAASDMSAV 248
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
81-228 |
1.35e-08 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 56.59 E-value: 1.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 81 IGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEqigvwapiLLLIARMIQGFSTGGEYSGAMVYIAESSPDKK 160
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501218165 161 RGILGS----GLEIGTLSGYIAASVIVTiltllltdeqmLSWGWRIPFLIAAPIGLV---GLYLrrhLDESPIFQ 228
Cdd:cd17362 126 RGLLVSlkelFIVLGILLGYVSGYAFAD-----------VVGGWRYMYGLAAPPALLlgiGMWF---LPPSPRWQ 186
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
81-359 |
1.48e-08 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 56.48 E-value: 1.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 81 IGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQIGVWAPILLLIARMIQGFstGGEYSGAMvyIAESSPDKK 160
Cdd:cd17345 53 LSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLMFILLFLNGWFQGM--GWPPSGRT--MVHWFSKKE 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 161 RGILGSGLEIG-TLSGYIAASVIVTILTLLLTDEQMLSWGwrIPFLIAAPIGLVGLYLRRHLDES----PI---FQEMEK 232
Cdd:cd17345 129 RGTWTSIWNIShNVGGGLVGPLAGLGLAIFGDGWWRGAFI--FPAIIAIIVAVIVLFLGKDTPESeglpPIeeyKGDYPE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 233 AQEESEDNEQFSFMDIL-KYHKKDFLLstVIVAFFNITNYM----ILSYIPSYLTQVLKVKETTGLLIISITMALMIPLA 307
Cdd:cd17345 207 EADGEEEEQELSAWEIFvKYVLKNKLL--WYIAIANVFVYLvrygILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGT 284
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 501218165 308 LYFGKLSDKVGNKRVVQIGLLGLALCSIPAFLLIGNGHIVAMFAGIFILGFF 359
Cdd:cd17345 285 LLAGWLSDKLFKGRRAPTGIIFMILVIVALIVYWLAPNVLVDLIALIALGFL 336
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
70-213 |
4.00e-08 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 52.27 E-value: 4.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 70 GTFAAAFLVRP-IGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLIARMIQGFSTGGEYSGA 148
Cdd:TIGR00880 1 GLLLAGYALGQlIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITV--------LIIARFLQGFGAAFALVAG 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501218165 149 MVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTILTllltdeqmLSWGWRIPFLIAAPIGLV 213
Cdd:TIGR00880 73 AALIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLA--------QFLGWRAPFLFLAILALA 129
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
81-443 |
4.49e-08 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 55.41 E-value: 4.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 81 IGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQIGVWapillliaRMIQGFSTGGEYSGAMVYIAESSPDKK 160
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVF--------RLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 161 RGIlgsgleIGTLSGYiaasvIVTILTLLLTDEQMLSWGWR-IPFLIAAPIGLVGLY------------LRRHLDE---- 223
Cdd:TIGR00898 214 RAI------VGTLIQV-----FFSLGLVLLPLVAYFIPDWRwLQLAVSLPTFLFFLLswfvpesprwliSQGRIEEalki 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 224 ------------SPIFQEMEKAQEESEDNEQFSFMDILKYHKKDFLLSTVIVAFFNITNymilsyipSYLTQVLKVKETT 291
Cdd:TIGR00898 283 lqriakingkklPAEVLSLSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAF--------SYYGLVLDLGNLG 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 292 G-LLIISITMALM-IPLALYFGKLSDKVGnKRVVQIGLLGLALCSIPAFLLIGNGH-----IVAMFAGIFILGFFLSVYE 364
Cdd:TIGR00898 355 GnIYLDLFISGLVeLPAKLITLLLIDRLG-RRYTMAASLLLAGVALLLLLFVPVDLyflrtALAVLGKFGITSAFQMVYL 433
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501218165 365 GTlpsllPALFFTDVRYRALSISFNISVsiFGGttpLVCSYLVHATGNPLAPAFYLTGVSVIGLIVFSVLFVTTSGRAL 443
Cdd:TIGR00898 434 YT-----AELYPTVVRNLGVGVCSTMAR--VGS---IISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPL 502
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
81-443 |
5.58e-08 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 54.95 E-value: 5.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 81 IGGIFFGRIGDKYGRK-IVLSTTIILMALSTLFIAllptyeQIGVWApiLLLIARMIQGFSTGGEYSGAMVYIAESSPDK 159
Cdd:cd17356 60 FGALISSFLSDRIGRKkSIQIGCVIYIIGAIIQVA------AIGKWY--QLIVGRIIAGLGVGFASVLVPVYQSEVAPKH 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 160 KRGILGSGLEIGTLSGYIAASVIVTILTLLLTDEQmlswgWRIPF---LIAAPIGLVGLYLrrhLDESP----------- 225
Cdd:cd17356 132 IRGTLVSLYQLAITIGILVAYCINYGTHKLDGSAQ-----WRIPLglqIVWGLLLLIGMFF---LPESPrwlyrtilgim 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 226 --IFQemekaqeesedneQFSFMDILKYHkkdfllstvIVAFFNITNYMILSyipSYLTQvlkvkettglLIISITMALM 303
Cdd:cd17356 204 lqLFQ-------------QLTGINYFFYY---------GTTIFQSTGLTGSS---PLLTS----------IILYIVNFVS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 304 IPLALYFgklSDKVGNKRVVQIGLLGLALC-----SIPAFLLIGNGHIV--------AMFAGIFILGFFLSVYEGTLPSL 370
Cdd:cd17356 249 TIPGLFF---VDKFGRRTCLLIGAAGMSIClfiyaAVGVRYLIPNPQSGtsnksagnGMIVFICLFIFSFATTWGPIAWV 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501218165 371 LPALFFtDVRYRALSISFNISVSIFGGTtplVCSYLVHATGNPLAPAFYL--TGVSVIGLIVFSVLFVTTSGRAL 443
Cdd:cd17356 326 YVAEVF-PLRVRSKGMALATAFNWLWNF---LISFFTPFIIGSIGFKYYYifAGCNLLAFIVVFFFVPETKGLTL 396
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
81-359 |
1.33e-07 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 53.53 E-value: 1.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 81 IGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPtyeqiGVWApilLLIARMIQGFSTGGEYSGAMVYIAESSPDKK 160
Cdd:TIGR00881 45 ISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST-----SLWV---MAALWALNGIFQGMGWPPCGRTVTKWFSRSE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 161 RGILGSGLEIG-TLSGYIAASVIVTILtllltdEQMLSWGWR--IPFLIAAPIGLVGLYLRRHLDESPIFQEME------ 231
Cdd:TIGR00881 117 RGTWVSFWNCShNVGGGLLPPLVLFGI------AELYSWHWVfiVPGIIAIIVSLICFLLLRDSPQSCGLPPAEempnee 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 232 ----KAQEESEDNEQFSFMDILKYHKKDFLLSTVIVAFFnITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLA 307
Cdd:TIGR00881 191 pdgdAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVY-VVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGT 269
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 501218165 308 LYFGKLSDK--VGNKRVVQIGLLGLALCSIPAFLLIGNGHIVAMFAGIFILGFF 359
Cdd:TIGR00881 270 LLAGWLSDKlfNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFL 323
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
161-372 |
1.97e-07 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 52.99 E-value: 1.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 161 RGILGSGLEIGTLSGYIAASVIVTILTLLLTDEQMlSWGWRIPFLIAAPIGLVGLYLRrhldespIFQEMEKAQEESEDN 240
Cdd:cd17332 134 RTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGNA-SRGYFLTALIIGIIGIILLLIC-------FFGTRERVVPPEEEK 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 241 EQFSFMDILKY--HKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALyFGKLSDKVG 318
Cdd:cd17332 206 SKLPLLKSLKAllKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLP-WPPLKKRFG 284
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 501218165 319 NKRVVQIGLLgLALCSIPAFLLIGNGHIVAMFAGIFILGFFLSVYEGTLPSLLP 372
Cdd:cd17332 285 KKKAFFIGLL-LAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLA 337
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
37-217 |
3.67e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 52.17 E-value: 3.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 37 WFDFGLYAYLAVILSQLFFSgvdNSGLQLVLTFGTFAAAflvrpIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALL 116
Cdd:cd17478 209 WVLSSLTTFLPFYLVQRGYS---LVFAGLLLSLFLFAGA-----IGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLT 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 117 PtyeqiGVWAPILLLIArmiqGFSTGGEYSGAMVYIAESSPDKKRgiLGSGLEIGTlsGYIAASVIVTILTLLltdeqML 196
Cdd:cd17478 281 P-----GIWSYILLVLA----GFLLFASFPVTVVLAQELLPGNVG--LASGLMMGL--SFGLGGIGAPVLGAL-----AD 342
|
170 180
....*....|....*....|.
gi 501218165 197 SWGWRIPFLIAAPIGLVGLYL 217
Cdd:cd17478 343 AFGLESVLLILALLPLLGALL 363
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
251-362 |
3.73e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 52.16 E-value: 3.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 251 YHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLgl 330
Cdd:cd17471 196 PVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFL-- 273
|
90 100 110
....*....|....*....|....*....|..
gi 501218165 331 aLCSIPAFLLIGNGHIVAMFAGIFILGFFLSV 362
Cdd:cd17471 274 -AGVLFYLGLALATSLWQLIALQLLNAIFIGI 304
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
37-354 |
9.94e-07 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 50.92 E-value: 9.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 37 WFDFGLYAYLAVILSQLF---FSGVDNSGL----QLVLTFGTFAAAFLVrPIGGIFFGRIGDKYGRKIVLstTIILMALS 109
Cdd:COG2270 17 LYDWANSAFSTVITTFVFppyFTSVAALGDpaaaTALWGYALAIAGLLV-ALLAPVLGAIADRSGRKKPF--LAFFTLLG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 110 TLFIALLPTYEQIGVWAPILLLIARMIQgfstggeYSGAMV----YIAESSPDKKRGILgSGleIGTLSGYIAASVIVTI 185
Cdd:COG2270 94 VLATAALFFVAPGGLWLGLLLFVLANIG-------FEGSLVfynaFLPDIATPEEIGRV-SG--LGWALGYLGGVLLLLI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 186 LTLLLTDEQML-----SWGWRIPFLIAA-PIGLVGLYLRRHLDESPIFQEMEKAQEESEDNEQF--SFMDILKYHK-KDF 256
Cdd:COG2270 164 NLALFLKPEAFglpdaGEAVRISFLLTAlWWLLFALPLFLFLPERPRPGPAPPRGAVRAGFRELrrTLRELRRYRDlLRF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 257 LLSTvivAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLALCSIP 336
Cdd:COG2270 244 LLAY---FFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLA 320
|
330 340
....*....|....*....|
gi 501218165 337 AFLLIGNGH--IVAMFAGIF 354
Cdd:COG2270 321 AYFLTTALAfwILGLLIGLV 340
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
55-433 |
1.34e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 50.27 E-value: 1.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 55 FSGVDNSGLQLVLTFGTFAAAFLvrpIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLIAR 134
Cdd:cd17330 26 FNKLGASGYYVGLLQSSYSLGQF---LASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNL--------WLLFLAR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 135 MIQGFsTGGEYSGAMVYIAESSPDKKR----GILGSGLEIGTLSGYIAASVIVTILTLLLtdeqmlswgwriPFLIAAPI 210
Cdd:cd17330 95 FLDGL-TGGNVSVAQAYIADITDEEERakafGIISAAFGLGFILGPALGGFLSTPYGYAL------------PFLVAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 211 GLVGLYLRRHldespifqemekaqeesedneqfsfmdILKYhkkdFLLSTVIVAFFNITNYMILSYIPSYLTQVLK-VKE 289
Cdd:cd17330 162 ALLNLVLVLF---------------------------FLPP----LRRLLLVYFLIALAFAGLESVFSLFLKDRFGfSPS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 290 TTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLlglaLCSIPAFLLIGNGHIV-AMFAGIFILGFFLSVyegTLP 368
Cdd:cd17330 211 QIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGL----LLAIIGLLLLPFASSVpLLVLAAAILAFGTGI---VFP 283
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501218165 369 SLLPALF-FTDVRYRALSISFNISV-SIFGGTTPLVCSYLvHATGNPLAPAFYLTGVSVIGLIVFSV 433
Cdd:cd17330 284 ALSALLSkSVPSKEQGKAQGIIQSLqSLARIIGPLLAGPL-YSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
40-215 |
1.42e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 50.24 E-value: 1.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 40 FGLYAYLAVILSQLFFsgvdNSGLQLVLTFGTFAAAFLvrpIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTy 119
Cdd:cd17324 215 FALYTYLAPFLTDVPG----FSSSAIIGLLLLFGVAGV---VGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPS- 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 120 eqigvwaPILLLIARMIQGFSTGGEYSGAMVYIAESSPDkKRGILGSgleIGTLSGYIAASVIVTILTLLLTdeqmlSWG 199
Cdd:cd17324 287 -------PLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE-ARGLASS---LYLAAYNLGGALGAALGGLVLD-----HGG 350
|
170
....*....|....*.
gi 501218165 200 WRIPFLIAAPIGLVGL 215
Cdd:cd17324 351 WAGVGWVGAALLLLAL 366
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
68-215 |
1.68e-06 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 49.94 E-value: 1.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 68 TFGTFAAAF-LVRPIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTyeqigVWapiLLLIARMIQGFsTGGEYS 146
Cdd:cd17388 39 HYGVLLALYaLMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPT-----LW---WLYLGRIIAGI-TGATGA 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501218165 147 GAMVYIAESSPDKKR----GILGSGLEIGTLSGYIAASVIVTIltllltdeqmlswGWRIPFLIAApiGLVGL 215
Cdd:cd17388 110 VAAAYIADVTPPEQRarnfGLLGAAFGLGFIAGPALGGLLGEI-------------SPRAPFLVAA--GLNGL 167
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
64-431 |
2.72e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 49.24 E-value: 2.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 64 QLVLTFGTFAAAFLvrpIGGIFFGRIGDKYGRKIVLSTTIILMALsTLFIALLPtyeqigvWAPILLLIARMIQGFSTGG 143
Cdd:cd17333 32 DVSVIFSSQNAGYL---IGSLLAGFLMKRLGRRRTLILGLLLISL-ALALIFAT-------PSIYLFVVLMFLAGLGAGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 144 EYSGAMVYIAESSPdKKRGILGSGLEigTLSGyIAASVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRrhlde 223
Cdd:cd17333 101 LDTGANTFVGALFE-ESSATRLNVLH--GFFG-LGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTL----- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 224 spiFQEMEKAQEESEDNEQFSfMDILKYHKKDFLLSTVIVAFFNI-TNYMILSYIPSYLTQVLKVKETTGLLIISITMAL 302
Cdd:cd17333 172 ---FPELPSARNPQQSVGAFS-ASASRLLRNPSIILGALALFLYVgAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 303 MIPLALYFGKLSDKVGNKRVVQIGLLGLalcSIPAFLLIGNGHIVAMFAGIFILGFFLSvyeGTLPSLLpALFFTDVRYR 382
Cdd:cd17333 248 ITIGRLLGGPISRRIKPHTLLVLSGSGA---LLGLLILLLAPTLVVGLVATALLGLFMA---ALFPTIL-SLGISNLPYA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 501218165 383 ALS-ISFNISVSIFGG-TTPLVCSYLVHATGNPLAPAFYLT-GVSVIGLIVF 431
Cdd:cd17333 321 KGKgTSVLLAAGSIGGaIIPFIMGFIAEAVGIQTAMLLITIlYAIIFVLALL 372
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
61-233 |
2.89e-06 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 49.19 E-value: 2.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 61 SGLQLVLTFGTFAAAFlvrpIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLIARMIQGFS 140
Cdd:cd17360 34 TGWQELIVSSTVAGAA----VGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEV--------LIVGRVLVGLG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 141 TGGEYSGAMVYIAESSPDKKRGILgsgleigtlsgyiaasviVTILTLLLTDEQMLSW-----------GWRIPFLIAAP 209
Cdd:cd17360 102 VGIASMTVPLYIAEAAPPRIRGRL------------------VTINVLFITGGQFVAYvingafsylpgGWRWMLGLAAV 163
|
170 180
....*....|....*....|....
gi 501218165 210 IGLVGLYLRRHLDESPIFQEMEKA 233
Cdd:cd17360 164 PAVLQFIGLLFLPESPRWPSTRRA 187
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
31-430 |
3.26e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.15 E-value: 3.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 31 IGNAMEWFDFG-LYAYLAVILSQLFFSGVDNSGLqlVLTFGTFAAAFlvrpiGGIFFGRIGDKYGRKIVLSTTIILMALS 109
Cdd:cd17329 6 IGSFLNRLGFFmVWPFMAIYLHQQLGLSASIVGL--VLALSAVAGIV-----ASLIGGRLADRFGRKPVMLAGLLLRALG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 110 TLFIALlptyeqigVWAPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRG----ILGSGLEIGTLSGYIAASVIVTI 185
Cdd:cd17329 79 FALLGF--------AHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTrafsLLYWAINLGVAIGPLLGGLLLLY 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 186 ltllltdeqmlswGWRIPFLIAAPI-GLVGLYLRRHLDEspifqEMEKAQEESEDNEQFSFMDILKYhkKDFLLSTVIVA 264
Cdd:cd17329 151 -------------SFRLLFLAAAVLfLLAALVLLFLLPE-----TRPKRRAAEKTEILRGYKIVLRD--RAFLLFLLASF 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 265 FFNITNYMILSYIPSYLTQVLK--VKETTGLLIIS--ITMALMIPLALYFGKLSDKVgnkrvvqIGLLGLALCSIPAFLL 340
Cdd:cd17329 211 LISLIYFQLESTLPVYVVEILGlgESLLGLLLALNalLIVLLQFPVARLVERFRLRK-------ILMIGILLFAIGFAVL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 341 IGNGHIVAMFAGIFILGFFLSVYEGTLPSLLPALffTDVRYRALSISFNISVSIFGGTTPLVCSYLVHATGNPLAPAFYL 420
Cdd:cd17329 284 AFANTLAVLILAMIVLTLGEMLVFPAVQTLVAAL--APPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLIL 361
|
410
....*....|
gi 501218165 421 TGVSVIGLIV 430
Cdd:cd17329 362 AALGLIAAAL 371
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
44-374 |
1.04e-05 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 47.50 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 44 AYLAVILSQLFFSGVDNSglqLVLTFGTFAAAflvrpIGGIFFGRIGDKYG-RKIVLSTTIILMALSTLFIALLptyeqI 122
Cdd:cd17337 18 GFLSPYLVDLGFSEAQAA---LLFTVYGLTVA-----IASWLSGVLAELFGpRRVMLIGLIIWLVFEVLFLAFG-----L 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 123 GVWAPILLLIARMIQGFStggeYS----GAMVYIAESSPDKKRGILGS------GLEIGTLSGYIAAS---VIVTILTLL 189
Cdd:cd17337 85 PSHNYPLMLLTYGLRGFG----YPlfaySFLVWITYRTPAERLGSAVGwfwfafTGGLPVLGSYLASFtipVIGEIGTLW 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 190 LtdeqmlSWGWripfliAAPIGLVGLYLRRhldESPIFQEMEKAQEESEDNEQFSFMdILKYHKKdFLLSTVIVAFFNIT 269
Cdd:cd17337 161 L------SLVF------VALGGLIALFLVR---DRTGEQPLANPSEEPLKELLSGIT-ILFRNPK-IAIGGIVRIINTLS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 270 NYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQI------GLLGLALCSIPafLLIGN 343
Cdd:cd17337 224 QFGFPVFMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWfggvgcAISTLLFYYVP--QLFGH 301
|
330 340 350
....*....|....*....|....*....|.
gi 501218165 344 GHIVAMFAGIFiLGFFLSVYeGTLPSLLPAL 374
Cdd:cd17337 302 NYWAALIAAIL-FGIGLAGF-VPLSALMPSL 330
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
263-436 |
1.08e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 47.42 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 263 VAFFNITNYMILSYIPSYLTQVLKVK---ETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVqigLLGLALCSIPAFL 339
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFglsASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVL---LLGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 340 LIGNGHIVAMFAGIFILGFFLSVYEGTLPSLLPALFFTDVRYRALSIsFNISVSIFGGTTPLVCSYLVHATGNPLAPAFY 419
Cdd:cd06174 78 FAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGL-LQAFGSVGGILGPLLGGILASSLGFGWRAVFL 156
|
170
....*....|....*..
gi 501218165 420 LTGVSVIGLIVFSVLFV 436
Cdd:cd06174 157 IAAALALLAAILLLLVV 173
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
84-431 |
1.15e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 47.55 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 84 IFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTyeqigvWAPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKR-- 161
Cdd:cd17380 52 VLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAY------SSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERsr 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 162 --GILGSGLEIGTLSGYIAASVIvtiltllltdeqMLSWGWRIPFLIAAPIGLVGLYLRRHLdESPIFqemekaqeesed 239
Cdd:cd17380 126 avSIVTAGSYLGTLLGGLIGPLL------------LEYYGWPSVFYFFGLLGLLWALVWLIY-LPPVW------------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 240 neqfsfmdilkyhkkdfllsTVIVAFF--NITNYMILSYIPSYLTQVLkVKETTGLLIISITMALMIPLALYFGKLSDKV 317
Cdd:cd17380 181 --------------------AIIVAHFcmNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 318 GNKRV---------VQIGLLGlalcsiPAFLLIGNGH-------IVAMFAGIFILGFFLSvyeGTLPSLLpalfftDVRY 381
Cdd:cd17380 240 ISRGWtvtsvrklmQSIGFLG------PALFLLLLSHtdsfslaLLCMSVALGLSAFSSS---GVLVNHQ------DIAP 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 501218165 382 RALSISFNISVSIfgGTTP-----LVCSYLVHATGNpLAPAFYLT-GVSVIGLIVF 431
Cdd:cd17380 305 NYAGIVFGISNTA--GTIPgivgvYLTGYILEATGS-WSLVFVLAaVVNLVGAVVF 357
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
75-444 |
1.76e-05 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 46.71 E-value: 1.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 75 AFLVRPIGGIFFgrigDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLIARMIQGFSTGGEYSGAMVYIAE 154
Cdd:cd17435 49 ALLASLTGGVLI----DRYGRRTAIILTSCLLVLGSLLLVCSVSY--------TVLIVGRIAIGVSISLSSIATCVYIAE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 155 SSPDKKRGILGSGLE----IGTLSGYIAASVIVTIltllltdeqmlSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFQEM 230
Cdd:cd17435 117 IAPQHRRGLLVSLNElmivIGILLAYISNYAFANV-----------SNGWKYMFGLVIPLAALQAIAMYFLPPSPRFLVM 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 231 ekaqeesEDNeqfsfmdilkyHKKDFLLSTVIVAFFNITNY-MILSYIPSYLTQV------LKVKETTGLLIISITMAlm 303
Cdd:cd17435 186 -------KDN-----------MRARLLIGLTLVFFVQITGQpNILFYASTVLKSVgfqsneAASLASTGVGVVKVVST-- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 304 IPLALyfgkLSDKVGNKRVVQIGLLGLALCSIPAFLLIGNGHIVAMFAGifilgffLSVYEGTLPSL-LPALFFTDVRYR 382
Cdd:cd17435 246 IPAIF----LVDKVGSKTFLCIGSSVMAVSLVTMGLWLSLASLLVYVAA-------FSIGLGPMPWLvLSEIFPGGIRGR 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501218165 383 ALSI--SFNISVSIFGGTTPLVCSYLVHatgnpLAPAFYLTGVSVIGLIVFSVLFV-TTSGRALK 444
Cdd:cd17435 315 AMALtsSMNWGINLLISLTFLTVTELIG-----LPWVCFIYTAMSLASLVFVIMFVpETKGCSLE 374
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
162-359 |
2.50e-05 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 46.84 E-value: 2.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 162 GILGSGLEIGTLSGYIAASVIVTILtLLLTDEQMLSWGWRIPFLIAApIGLVGLYLRRHLDESPifqemEKAQEESEDNE 241
Cdd:PRK08633 142 GLLEAFTIVAILAGTALFSFLFESV-NGNTPSEILGRIAPAGLVLLA-VAVLGLIFAYRLPKVP-----AAAPEVFDKKK 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 242 QFSFMDILK-----YHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPL-ALYFGKLSD 315
Cdd:PRK08633 215 YLFPKLLWRnlkllRSDRVLWLAIIGLSYFWFISQLAQANFPAYAKEVLGLDNTFQVQYLLAASAIGIGIgSLLAGRLSG 294
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 501218165 316 KVGNKRVVQIGLLGLALCSipaFLLIGNGHIVAMFAGIFILGFF 359
Cdd:PRK08633 295 RHIELGLVPLGALGLALSL---FLLPTAPSLASVLVLFFLFGFS 335
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
81-360 |
2.92e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.11 E-value: 2.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 81 IGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLIARMIQGFSTGGEYSGAMVYIAESSPDKK 160
Cdd:cd17312 53 VGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSL--------WFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKE 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 161 RG----ILGSGLEIGTLSGYIAASVIVtiltllltdeqmLSWGWRIPFLIAAPIGLVG-LYLRRHLDESPIFQemekaqe 235
Cdd:cd17312 125 RGtvygIWSTSHNFGGILAPILAASLA------------SYYGWRAAFLVPGIVGLVVaIILFFFLRDSPPYV------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 236 esedneqfsfmdilkyhkkdFLLSTVIvAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSD 315
Cdd:cd17312 186 --------------------WVLSLAY-AFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSD 244
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 501218165 316 KVGNKRVVQIGLLGLALCSIPA--FLLIGNGHIVAMFAGiFILGFFL 360
Cdd:cd17312 245 KLFGGRRAPIAVIYMLLMTLSLalFWFFPHNKLLSIVLL-FLIGFFV 290
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
59-230 |
3.72e-05 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 45.70 E-value: 3.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 59 DNSGLQLVLTFGTFAAAflvrpIGGIFFGRIGDKYGRKIvlstTIILMALSTLFIALLptyeqiGVWAPIL--LLIARMI 136
Cdd:cd17361 49 DDQLLQLFTSSLYLAGL-----VASLLASYVTRKWGRKP----SMLIGGVLFLVGAAL------NAAAQNIamLIVGRIL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 137 QGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIvTILTllltdEQMLSWGWRIPFLIAAPIGLVGLY 216
Cdd:cd17361 114 LGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANLI-NYGT-----SKIKPNGWRLSLGLAAVPALILLL 187
|
170
....*....|....
gi 501218165 217 LRRHLDESPIFQEM 230
Cdd:cd17361 188 GSLFLPETPNSPQL 201
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
34-218 |
5.15e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.26 E-value: 5.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 34 AMEWFDFGLYAYLAVILSQLFFSGVDNSGLQLVLTFGT--------FAAAFLVRPIGGIFFGRIGDKYGRKIVLSTTIIL 105
Cdd:cd17473 193 ALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGsaaliglaLAIASLAGAIGALLFGRLKRRLGKRRLLAIGFAL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 106 MALSTLFIALLPTYeqigvwapILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTI 185
Cdd:cd17473 273 MALGFLLLALASGL--------WVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGP 344
|
170 180 190
....*....|....*....|....*....|...
gi 501218165 186 LTLLLTDEQMLswgWRIPFLIAAPIGLVGLYLR 218
Cdd:cd17473 345 LVNLTGGLSGA---FLILGVLALVLAIVLLLLR 374
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
60-397 |
8.27e-05 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 44.71 E-value: 8.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 60 NSGLQLVLTFGTFAAA--FLVRPIGGIFFgrigDKYGRKIVLSTTIILMALSTLFIALLPTyeqigvwAPILLLIARMIQ 137
Cdd:cd17314 34 GYSSSQIATAASLSNLgmLLTQPILGFIA----DSFGPRPLMALAGIMVLAGYTYLSYVFN-------SFPLSYACFVFI 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 138 GFSTGGEYSGAMVYIAESSPDKKrgilgsGLEIG-TLSGYIAASVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLY 216
Cdd:cd17314 103 GAGTGILYGSAVLVTTQYFPDTK------GLALGlPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVVSL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 217 LrrHLDESPIFQEMEKAQEESEDNEQFSFMDilkyhKKDFLLSTVIVAFFniTNYMILSYIPSYLTQVLKVKETTGLLII 296
Cdd:cd17314 177 L--GFKEPPDNQARLHVQKKKTQTMGEIFRD-----KVFWILFIAIFLVL--IGGFLFIANMASLVRSLQLDAPSFVTKL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 297 SITMALMIPL-ALYFGKLSDKVGNKRVVQIGLLGLALCSIPAFLLIGNGHIVAMFAGIFILGFFLSVYEGTLPSLLPALF 375
Cdd:cd17314 248 MSIYGLFNAFgRLLWGIVADFFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVF 327
|
330 340
....*....|....*....|....
gi 501218165 376 FTDVRYRALSISFNI--SVSIFGG 397
Cdd:cd17314 328 GTESFATLYGILLFApaIGSILGP 351
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
76-381 |
9.86e-05 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 44.49 E-value: 9.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 76 FLVRPIGGIFFGRIGdkYGRKIVLSTtiILMALSTLFIALLPTYeqigvwapILLLIARMIQGFSTGGEYSGAMVYIAES 155
Cdd:cd17384 45 LITNPIVGPLTNRIG--YSLPMFVGF--VIMFISTLLFAFGESY--------GVLFLARALQGVGSACSSVAGMGMLASL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 156 SPDKKR-----GILGSGLEIGTLSGYIAASVIVTILtllltdeqmlswGWRIPFLIAAPIGLVGLYLRRHldespiFQEM 230
Cdd:cd17384 113 YPDDKErgkamGIALGGLALGVLVGPPFGGVMYEFV------------GKSAPFLILAFLALLDGALQLF------ILQP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 231 EKAQEESEdnEQFSFMDILKyhKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKE-TTGLLIISITMALMIPLALy 309
Cdd:cd17384 175 SVKSEESE--EGTPWKTLLK--DPYILIAAGAICFSNSGIAILEPCLPIWMMETMCPPKwQLGTAFLPDSIGYLIGTNL- 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 501218165 310 FGKLSDKVGNKRVVQIGLL--GLALCSIPAflligNGHIVAMFAGIFILGFFLSVYEGTLPSLLPALffTDVRY 381
Cdd:cd17384 250 FGPLAHKIGRWLCSLLGMLlvGISLILIPL-----AKNIYGLIIPHFGLGLGIGMVDSSMMPLLAYL--VDLRH 316
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
19-215 |
1.22e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.07 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 19 SKQAKKAVIATGIgNAMEWFDFGLYAYLAvilSQLFFSgvdnsglqLVLTFGTFAAAFLVRPIGGIFFGRIGDKYGRKIV 98
Cdd:cd17370 199 PKAFWLYLLAVAL-FALGNFSFAFLILRA---QELGLS--------AALIPLLYALFNLVYALAAYPAGRLSDRIGRKKL 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 99 LSTTIILMALSTLFIALLPtyeqigvwAPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKR----GILGSGLEIGTLS 174
Cdd:cd17370 267 LILGYLSLALAYLGFALGS--------SLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRgtayGLFNTVVGIGWLL 338
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 501218165 175 GYIAASVIVTiltllltdeqmlSWGWRIPFLIAAPIGLVGL 215
Cdd:cd17370 339 ASLIAGYLWD------------LISPSAAFLFSAVLALIAL 367
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
72-357 |
2.97e-04 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 43.19 E-value: 2.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 72 FAAAFLVRPIGGIFFGRIGDKYGRKivlSTTIILMALSTLFIALLPTYEQIGVwapILLLIARMIQGFSTGGEYSGAMVY 151
Cdd:TIGR00894 82 LSSHFYGQIIIQIPVGYLAGKYVFK---WSIGIGMFLSSVISIVIPWAAGGGI---ALVVFCRVIQGLAQGSVSPATHKI 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 152 IAESSPDKKRGILGSgleiGTLSGYIAASVIVTILTLLLTDEQMlswGWRIPFLIAAPIGLVGLYL---------RRHLD 222
Cdd:TIGR00894 156 IVKWAPPKERSRLLG----MSTSGFQLGTFIFLPISGWLCESWG---GWPMIFYVFGIVGCAWSLLwfvfpaddpSIHPC 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 223 ESpifqEMEKA-------QEESEDNEQFSFMDILKYhKKDFLLSTVIVAFFNITNYMILsYIPSYLTQVLKVKETTGLLI 295
Cdd:TIGR00894 229 IS----KFEKKyinsslqGQKGSTRQSLPIKAIPKS-LPVWAIWFAIFGHFWLYTILPT-YLPTFISWVLRVSGKENGLL 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 296 ISITMALMIPLALYFGKLSD----------KVGNKRVVQIGLLGLALC------------SIPAFLLIGNGHIVAMFAGI 353
Cdd:TIGR00894 303 SSLPYLFAWLCSIFAGYLADflkssktlslTAARKIFNGIGGLGPGIFayalpylsaafyLTIIILTLANAVSSGPLAGV 382
|
....
gi 501218165 354 FILG 357
Cdd:TIGR00894 383 LINS 386
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
87-434 |
3.24e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 42.99 E-value: 3.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 87 GRIGDKYGRKIVLSTTIILMALSTLFIallPTYEQIGVWApilLLIARMIQGFSTGGEYSGAMVYIAESSPDKKRGILG- 165
Cdd:cd17318 77 GYLAEKYGAKRVLGYSILITALLTLLT---PLAARGGYGA---LIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTs 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 166 ---SGLEIGTLSGYIAASVIVTiltllltdeqmlSWGWRIPFLIAAPIGLVGlylrrhldeSPIFqemekaqeesedneq 242
Cdd:cd17318 151 iaySGSQFGTVIAMPLSGFLCE------------SLGWPSIFYIFGGLGLLW---------CLLW--------------- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 243 fsfmdilkyhkkdFLLS----TVIVAFF--NITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDK 316
Cdd:cd17318 195 -------------FFLVlpvwAIVVAHFghNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADW 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 317 VGNKRVVQIGLLGLALCSI----PAFLLIGNGH-------------IVAMFAGIFILGFFLSV------YEGTLpsllpa 373
Cdd:cd17318 262 LRSRGILSTTTVRKLFTSIgflgPGVFLIALGYlgsnatlavvfltLSVGLSGACYSGFLVNHldlapnYAGTL------ 335
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 501218165 374 lfftdvryraLSISFNISvSIFGGTTPLVCSYLVHATGNPLA--PAFYLT-GVSVIGLIVFSVL 434
Cdd:cd17318 336 ----------MGITNTAA-TIAGIISPLIVGAIVKNDQTIGQwrIVFFISaAIYILGAIFYLIF 388
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
64-165 |
3.25e-04 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 42.72 E-value: 3.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 64 QLVLTFGTFaaaflvrpIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLIARMIQGFSTGG 143
Cdd:cd17379 39 QSSLNLGFL--------IGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY--------PWFLIFRFLQGLFGKG 102
|
90 100
....*....|....*....|..
gi 501218165 144 EYSGAMVYIAESSPDKKRGILG 165
Cdd:cd17379 103 GWMTGYVLVTEFVGSKYRRTVG 124
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
57-334 |
3.95e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 42.75 E-value: 3.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 57 GVDNSGLQLVLTFGTFAAAFLVrPIGGIFFGRIGDKygrkIVLSTTIILMALSTLFIALLPTYEqigvwapiLLLIARMI 136
Cdd:TIGR00711 33 GSSLSQVQWVITSYMLANAISI-PLTGWLAKRFGTR----RLFLISTFAFTLGSLLCGVAPNLE--------LMIIFRVI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 137 QGFSTGGEYSGAMVYIAESSPDKKRGIlgsGLEIGTLsGYIAASVIVTILTLLLTDeqmlSWGWRIPFLIAAPIGL---- 212
Cdd:TIGR00711 100 QGFGGGPLIPLSFSTLLNIYPPEKRGR---AMAIWGL-TVLVAPALGPTLGGWIIE----NYHWRWIFLINVPIGIivvv 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 213 -VGLYLRRHLDESPI----------------FQEM-EKAQEESEDNEQF------------------------SFMDILK 250
Cdd:TIGR00711 172 vAFFILPRDKPAASEnfdflgllllsvglgsLLYGlSEGPERGWFDSNEililsitglvaiiafvvweltddnPLVDLRL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 251 YHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKET-TGLLII--SITMALMIPLAlyfGKLSDKVGNKRVVQIGL 327
Cdd:TIGR00711 252 FKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALqAGLHILpvGLAPMLSSPIA---GRMGDKIDPRKLVTIGL 328
|
....*..
gi 501218165 328 LGLALCS 334
Cdd:TIGR00711 329 ILYAVGF 335
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
81-437 |
5.43e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 42.18 E-value: 5.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 81 IGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLIARMIQGFSTGGEYSGAMVYIAESSPDKK 160
Cdd:cd17323 49 LGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAM--------LIILRFLQGFFGSSPLAIGAGTIADLFTPEE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 161 RGILGSGLEIGTLSGYIAASVIVTILTllltdeqmLSWGWRIPFLIAAPIGLVGLYLrrhldespifqemekaqeesedn 240
Cdd:cd17323 121 RGKAMGVYSLGPLLGPALGPIIGGFIT--------QSLGWRWIFWFLAIISGFCLIL----------------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 241 eQFSFMDILkyhkkdfLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKE-TTGLLIISITMALMIpLALYFGKLSDKVGN 319
Cdd:cd17323 170 -IFLFLPIV-------LLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPgEVGLMYLPIGIGALI-GSIIGGRLSDYYYR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 320 KRVVQ-----------IGLLGLALCSIPAFLLIG-----NGHIVAMFAGIFILGFFLSVYEGTLPSLLPALFftdVRYRA 383
Cdd:cd17323 241 RLKKKnggkpepearlPPAFIGAFLFPIGLFIFGwtiypHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSY---PKYAA 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 501218165 384 LSIS-FNISVSIFGGTTPLVCSYLVHATGnplapafYLTGVSVIGLIVFSVLFVT 437
Cdd:cd17323 318 SALAaNTLVRSIFAAIFPLFAQPMFNNLG-------VGWAFTLLAFISLAMIPIP 365
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
44-362 |
5.72e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 42.23 E-value: 5.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 44 AYLAVILSQLffsGVDNSGLQLVLTFGTFAAaFLVRPIGGIFFGRIGDKYGRKIVLstTIILMALSTLFIALLPTYEQIG 123
Cdd:cd17313 20 SYVPPILQTL---GLSHALIGFVWTLGPILG-LFVQPLVGSLSDRCNSRIGRRRPF--ILVGAPLAALGLILIPNAADIG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 124 --------VWAPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKR----GILGSGLEIGTLSGYIAASVIVTILTLLLT 191
Cdd:cd17313 94 lalgdgprTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRskanGIINFMGGLGGVLGYLLGAILWDHNWFGFA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 192 DEQMLswgwRIPFLIAAPIGLVGLYLRRHL-DESPIFQEMEKAQEESEDNEQFSFMDILKYHKKDFLLSTVIVAFFNITN 270
Cdd:cd17313 174 LGGNL----KVPFYIGAIILLVCVLVTLFFvKEPPLSPEAGEHSENPSLGEVLKSLLKLLKIMPRSLLRLLLVIFFWWIA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 271 YM-ILSYIPSYLTQVLKVKETT--------------GLLIISITMALMiplALYFGKLSDKVGNKRVVQIGLLGLALCSI 335
Cdd:cd17313 250 FFpFELFFTDYMGEEVYHGTSAasshygagvrmgawGLLIFSLAFLIF---SLPIGKLGKKIGRKKVYLIGLVLFAVGMA 326
|
330 340
....*....|....*....|....*...
gi 501218165 336 PAFLLigngHIVAMFAGIFIL-GFFLSV 362
Cdd:cd17313 327 LMALV----HNVTVALVLFALgGIGWAT 350
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
257-443 |
6.01e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 41.72 E-value: 6.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 257 LLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLALCSIP 336
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 337 AFLLIGnghIVAMFAGIFILGFFLSVYEGTLPSLLPALFftDVRYRALSISFNISVSIFGGTT-PLVCSYLVHATGNPLa 415
Cdd:COG0477 96 CGLAPS---PELLIAARALQGIGAGGLMPGALALIAELF--PARERGRALGLWGAAIGLGLALgPLLGGLLVAALGWRW- 169
|
170 180
....*....|....*....|....*...
gi 501218165 416 pAFYLTGVSVIGLIVFSVLFVTTSGRAL 443
Cdd:COG0477 170 -IFLINAPLGLLALVLRLRLPESRGLLL 196
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
81-165 |
6.24e-04 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 41.96 E-value: 6.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 81 IGGIFFGRIGD-KYGRKIVLSTTIILMALSTLFIALLPTYeqigvWAPILLliaRMIQGFSTGGEYSGAMVYIAESSPDK 159
Cdd:cd17378 48 IGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNY-----WVYAFL---RFLTGFGRSGIGTCALVLATEPVGPK 119
|
....*.
gi 501218165 160 KRGILG 165
Cdd:cd17378 120 WRGQVG 125
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
81-178 |
6.61e-04 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 42.00 E-value: 6.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 81 IGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEqigvwapiLLLIARMIQGFSTGGEYSGAMVYIAESSPDKK 160
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYP--------VLMVGRFVAGIGVGFALMIAPVYTAEVAPASS 118
|
90 100
....*....|....*....|..
gi 501218165 161 RGILGSGLEI----GTLSGYIA 178
Cdd:cd17437 119 RGFLTSFPEIfiniGILLGYVS 140
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
84-371 |
7.51e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 41.82 E-value: 7.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 84 IFFGRIGDKYGRKIvlsttIILMALSTLFIALLPTYEQIGVWapiLLLIARMIQGfsTGGEYSGAMVYIAESSPDKKR-- 161
Cdd:cd17472 50 IPFGLLSDRIGRKP-----VILFGLLLFIAGSLLAAYATSIY---GLILGRALQG--SGAISSVVMALLADLTREENRtk 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 162 --GILGSGLEIGTLSGYIAASVIVTIltllltdeqmlsWGWRIPFLIAAPIGLVGL-YLRRHLDESPIfqemekaQEESE 238
Cdd:cd17472 120 amALIGASIGIAFAISMVLGPLLAAH------------LGVSGLFLITAILSLVSLlILLFFVPDPPK-------IVQIS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 239 DNEQFSFMDILKyhKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKE------TTGLLIISITMALMIPLALYFGK 312
Cdd:cd17472 181 EKEKKKLKKLLK--NKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGqlwkvyLPAILIGFILMVPFVIYAEKKGK 258
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501218165 313 LsdkvgnKRVVQIGLLGLALCSIpaFLLIGNGHIVAMFAG--IFILGFFLsvYEGTLPSLL 371
Cdd:cd17472 259 M------KQVFVSSILLIAVGFL--LLLFAATSLWLLIIGliIFFIGFNL--LEALLPSLV 309
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
71-430 |
8.62e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 41.44 E-value: 8.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 71 TFAAAFLVRPIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwaPILLLIARMIQGFSTGGEYSGAMV 150
Cdd:cd17353 43 AFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISL-------PLLFLGYGVLGGIGAGIGYITPVS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 151 YIAESSPDkKRGiLGSGLEIG--TLSGYIAASVIVTILTLLLTDEQMLSWGwrIPFLIAAPIGlvGLYLRRHLDESPIFQ 228
Cdd:cd17353 116 TAVKWFPD-KRG-LATGIVIAgfGLGSLIFSPLIAYLINTVGVPTTFLILG--IIFLIIIVIG--AFLIRDPPKGWVPPG 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 229 EMEKAQEESEDNEQFSFMDILKyhKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLAL 308
Cdd:cd17353 190 VDPLANNAENSPRDYTPREMLR--TPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRP 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 309 YFGKLSDKVGNKRVVQIGLLGLALCSipAFLLIGNGHIVAMFAGIFILGFFLSVYEGTLPSLLPALFFTD---VRYRALS 385
Cdd:cd17353 268 FWGWLSDKIGRKNTLSIAFLIQGVAM--FLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKnagTNYGLLY 345
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 501218165 386 ISFNISvSIFGgttPLVCSYLVHATGnpLAPAFYLTGV-SVIGLIV 430
Cdd:cd17353 346 TAKGVG-GLIG---PIIAAYVLYTGG--YNAAFIIAAAlSLVALAL 385
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
73-361 |
9.39e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 41.52 E-value: 9.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 73 AAAFLVRpiggIFFGRIGDKYGRKIVLSTTIILMALSTLFIALL-PTYEQigvwapilLLIARMIQGFStGGEYSGAMVY 151
Cdd:TIGR00886 48 LAGAVLR----IILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSV--------LLLIRLFIGIA-GGSFASCMPW 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 152 IAESSPDKKRG----ILGSGLEIGTLSGYIAASVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIF 227
Cdd:TIGR00886 115 ISFFFPKKIQGtalgLAAGWGNMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIVPAGILLLPALLIFFVGADTPPG 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 228 QEMEKAQEESEdneqfsFMDILKYhkkdflLSTVIVAFFNITNY----MILSYIPSYLTQVLKVKETTGLLIISI---TM 300
Cdd:TIGR00886 195 KPATGKLSFKE------ALKVFGN------RHTWILALLYSVTFgsflGVSSIFAMLFKDQFGLSKVQAGAYASLggfLG 262
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501218165 301 ALMIPLAlyfGKLSDKVGNKRVVQIGLLGLALCSIPAFLLIGNGHIVAMFAGIFILGFFLS 361
Cdd:TIGR00886 263 SLARPAG---GAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALFFFA 320
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
34-143 |
9.50e-04 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 41.30 E-value: 9.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 34 AMEWFDFGLYAYLAVILSQLFFSGVdnsglqlvltfgtfaaaflvrPIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFI 113
Cdd:cd17377 28 VSEWFLVGNAAYKVSLASSFFFAGV---------------------LIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFN 86
|
90 100 110
....*....|....*....|....*....|
gi 501218165 114 ALLPTYEqigvwapiLLLIARMIQGFSTGG 143
Cdd:cd17377 87 ALAPSYE--------FFAVSRFLVGVMNGG 108
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
17-136 |
1.07e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 41.08 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 17 VNSKQAKKAVIATGIGNAMEW-------FDFGLYAYLAVILSQLFFsgvDNSGLQLVlTFGTFAAAF-----LVRPIGGI 84
Cdd:cd17341 188 KASALEFLKVQLAVLKNYRTWilsllygVTFGSFVGFSNVLPTYFK---TRFGLPLV-TAGILAALFplagaLARPAGGW 263
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 501218165 85 ffgrIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQIGVWAPILLLIARMI 136
Cdd:cd17341 264 ----LSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGL 311
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
63-217 |
1.16e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.00 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 63 LQLVLTFGTFAAAFLVRP------IGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQIGVWAPILLLIarmi 136
Cdd:cd17321 195 LQGVLGYSPLQAGLALLPlalamlVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLL---- 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 137 qGFSTGGEYSGAMVYIAESSPDKKRGIlGSGLEIGT--LSGYIAASVIVTILTLLLTDEQMLSW--------------GW 200
Cdd:cd17321 271 -GLGLGLFATPLTNAALSSVPKEKAGA-ASGILNTArqLGGALGVALLGALLTAGLSANLGDSGvaallsaaaaafaaGF 348
|
170
....*....|....*..
gi 501218165 201 RIPFLIAAPIGLVGLYL 217
Cdd:cd17321 349 HLAFLVAAALALLAALL 365
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
76-215 |
1.21e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 41.07 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 76 FLVRPIGGIFFGRIGDKYGRKIVLSTT-------IILMALSTLFIALLPTYEQIGVWAPILLLIARMIQGFStggeYSGA 148
Cdd:cd17318 245 YLAMWICSIVGGYLADWLRSRGILSTTtvrklftSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGAC----YSGF 320
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501218165 149 MVYIAESSPDKKRGILGSGLEIGTLSGYIAasviVTILTLLLTDEQMLSwGWRIPFLIAAPIGLVGL 215
Cdd:cd17318 321 LVNHLDLAPNYAGTLMGITNTAATIAGIIS----PLIVGAIVKNDQTIG-QWRIVFFISAAIYILGA 382
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
38-340 |
1.31e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.05 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 38 FDFGLYAYLAVILSQLFFSGVDNSGLQLVLTFGTFAAAFLVRPIGgIFFGRIGDkygRKIVLSTTIILMALSTLFIALLP 117
Cdd:cd17490 8 FWFSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLG-ILSDRIGK---RKLFIIIGLLFTVLASLIMILFP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 118 TyeqigvwaPILLLIARMIQGFSTGGEYSGAMVYIAESSPD---KKRGILGSGLEIGTLSGYIAASVIVTiltllltdeq 194
Cdd:cd17490 84 S--------PWGLLIARFLSGIAAATWVSFTVLYASYFPPDeaaKAMGLINLVNNLGQLIAFLIGGLIAE---------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 195 mlSWGWRIPFLIAAPIGLVGLYLRRHLDEspifqemekaQEESEDNEQFSFMDILKYHKKDFLLstvIVAFFNITNYMIL 274
Cdd:cd17490 146 --HFGMRAPFLLAALAGVLGFILSLFIKE----------ERREKKPVLTELKELLSVLKDKKLL---FFSLLAILQQMIT 210
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501218165 275 SYIPSYLT-QVLKVKETTGLLIISITMALMIP--LALYFG--KLSDKVGNKRVVQIGLLGLALCSIPAFLL 340
Cdd:cd17490 211 FSTTFGFTpLIAKQLGASSFQLGLLSIIYLLPnaLASLLSgtLFYKKLGERNTIIIGFLLLGAYCFLIPFA 281
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
260-358 |
1.41e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.66 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 260 TVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIpLALYFGKLSDKVGNKRVVQIGLLGLALCSIpAFL 339
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALL-ARPFAGRLLDRFGRKRLLLIGLLIFALATL-LYL 79
|
90
....*....|....*....
gi 501218165 340 LIGNghIVAMFAGIFILGF 358
Cdd:cd17489 80 LATS--VALLLVLRLIHGI 96
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
272-443 |
1.62e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 40.64 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 272 MILSYIPSYLTQVLKVKET--TGLLIISITMALMIPLALYFGKLSDKVGNKRVVQIGLLGLALCsipaFLLIGN-GHIVA 348
Cdd:cd17330 14 IVFPVLPFYVREFNKLGASgyYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS----YVLLGLsRNLWL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 349 MFAGIFILGFFlSVYEGTLPSLLPALffTDVRYRALSISFnISVSIFGGTT--PLVCSYLVHAtgNPLAPAFYLTGVSVI 426
Cdd:cd17330 90 LFLARFLDGLT-GGNVSVAQAYIADI--TDEEERAKAFGI-ISAAFGLGFIlgPALGGFLSTP--YGYALPFLVAAALAL 163
|
170
....*....|....*..
gi 501218165 427 GLIVFSVLFVTTSGRAL 443
Cdd:cd17330 164 LNLVLVLFFLPPLRRLL 180
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
57-140 |
1.96e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 40.28 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 57 GVDNSGLQLVLTFGTFAAAflvrpIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLIARMI 136
Cdd:PRK11102 22 GVSAGSVQMTLSAYILGFA-----IGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQ--------LIYMRFL 88
|
....
gi 501218165 137 QGFS 140
Cdd:PRK11102 89 HGLA 92
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
72-336 |
2.00e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 40.29 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 72 FAAAFLVRPIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTyeqigVWApilLLIARMIQGFsTGGEYSGAMVY 151
Cdd:PRK09874 60 FSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQN-----IWQ---FLILRALLGL-LGGFVPNANAL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 152 IAESSPDKKrgilgSGLEIGTLS-GYIAASVIVTILTLLLTDeqmlSWGWRIPFLIAAPIGLVGLYLRRHLDESPiFQEM 230
Cdd:PRK09874 131 IATQVPRNK-----SGWALGTLStGGVSGALLGPLAGGLLAD----SYGLRPVFFITASVLFLCFLVTLFCIREN-FQPV 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 231 EKaQEESEDNEQFSFMDILKYHKKDFLLSTVI-VAFFNITNYMILsYIPSYLTQVLKVKETTGlLIISITMALMIPLALY 309
Cdd:PRK09874 201 SK-KEMLHMREVVTSLKNPKLVLSLFVTTLIIqVATGSIAPILTL-YVRELAGNVSNIAFISG-MIASVPGVAALLSAPR 277
|
250 260
....*....|....*....|....*..
gi 501218165 310 FGKLSDKVGNKRVVQIGLLGLALCSIP 336
Cdd:PRK09874 278 LGKLGDRIGPEKILITALIFSVLLLIP 304
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
63-187 |
2.32e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 40.25 E-value: 2.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 63 LQLVLTFGTFAAAFLVRP--IGGIFF----GRIGDKYGRKIVLSTTIILMALSTLFIALLptYEQIGVWapiLLLIARMI 136
Cdd:cd17503 205 LQNVLGYSAFESGLVLAPggLASAILsplvGRLLDKFGPRLLLLAGLLLLALGTLLLAFL--TPDTSLW---LIILPLFI 279
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 501218165 137 QGFSTGGEYSGAMVYIAESSPDKKRGiLGSGL--EIGTLSGYIAASVIVTILT 187
Cdd:cd17503 280 RGLGMGLVFMPLNTLALNSLPPEQIG-DATALfnTIRQLGGSIGTALLATLLT 331
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
81-356 |
2.55e-03 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 40.08 E-value: 2.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 81 IGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEqigvwapiLLLIARMIQGFSTGGeYSGAMVYIAESSPDKK 160
Cdd:PRK10091 53 VGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYL--------MLAIGRLVSGFPHGA-FFGVGAIVLSKIIKPG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 161 RGILGSGLEIGTLSgyIAASVIVTILTLLltdEQMLSWgwRIPFLIAAPIGLVGLYLrrhldespIFQEMEKAQEESEDN 240
Cdd:PRK10091 124 KVTAAVAGMVSGMT--VANLLGIPLGTYL---SQEFSW--RYTFLLIAVFNIAVLAS--------IYFWVPDIRDEAKGG 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 241 --EQFSFmdiLKYHKKDFLLSTVIvaFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKVG 318
Cdd:PRK10091 189 lrEQFHF---LRSPAPWLIFAATM--FGNAGVFAWFSYIKPYMMFISGFSETSMTFIMMLVGLGMVLGNLLSGRLSGRYS 263
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 501218165 319 NKRVVQI--GLLGLALCSIPAFLLIGNGHIVAMF---AGIFIL 356
Cdd:PRK10091 264 PLRIAAVtdFIIVLALLMLFFFGGMKTASLIFAFiccAGLFAL 306
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
80-237 |
2.75e-03 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 39.91 E-value: 2.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 80 PIGGIF----FGRIGDKYGRK--IVLSTTI-----ILMALSTLFiallPTYEqigvwapiLLLIARMIQGFSTGGEYSGA 148
Cdd:cd17432 60 PLGGLFgsllVGPLVIRLGRKgtLLLNNIFaivaaILMGLSKIA----KSFE--------MIIVGRFLVGINAGISLNVV 127
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 149 MVYIAESSPDKKRGILGSGLEIGTLSGYIAASvIVTILTLLLTDEqmlswGWRIPF-LIAAPiGLVGLYLRRHLDESPIF 227
Cdd:cd17432 128 PMYLGESAPKNLRGAVGLVPAIFITLGILLGQ-VLGLRELLGNEE-----GWPLLLaLTGVP-ALLQLLTLPFFPESPRY 200
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170
....*....|
gi 501218165 228 QEMEKAQEES 237
Cdd:cd17432 201 LLIEKGDEEA 210
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| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
81-182 |
3.30e-03 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 39.90 E-value: 3.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 81 IGGIFFGRIGDKYGRKIVLsttIILMALSTLFiALLPTYEQigvwAPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKK 160
Cdd:cd17440 49 VGAFFWGGLADKVGRRQSL---LICMSVNGFF-AFLSSFVQ----GYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREK 120
|
90 100
....*....|....*....|..
gi 501218165 161 RGILGSGLEIGTLSGYIAASVI 182
Cdd:cd17440 121 RGEHLSWLCMFWMIGGIYASAM 142
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| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
40-162 |
5.46e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.98 E-value: 5.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 40 FGLYAYLAVILSQLFfsGVDNSGLQLVLTFGTFAAAflvrpIGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTY 119
Cdd:COG2270 255 QTVIAFAGIYAAGVL--GFSTTELIVFGLLVQIVAA-----LGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTA 327
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90 100 110 120
....*....|....*....|....*....|....*....|...
gi 501218165 120 EQIgvWAPILLLiarmiqGFSTGGEYSGAMVYIAESSPDKKRG 162
Cdd:COG2270 328 LAF--WILGLLI------GLVMGGIQALSRSLLARLIPPGREA 362
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|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
83-213 |
5.71e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 39.14 E-value: 5.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 83 GIFFGRIGDKYGRKIVLSTTIILMALSTLFIALlptyeqigvwaPILLLIARMIQGFSTGGEYSGAMVYIAESSPDKKR- 161
Cdd:cd17336 55 VLLVSYFGGRGHRPRWIGIGSILMGLGCFLLAL-----------PHFLFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSp 123
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 501218165 162 ---GILGSGLEIGTLSGYIAASVIVTI-------LTLLLTDEQMLSWGWRIPFLIAAPIGLV 213
Cdd:cd17336 124 lyiGILYAMRVLGPALGFLLGSFLLRIyvdfsrvPLGITPDDPRWIGAWWLGFLILGILLLI 185
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| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
81-182 |
6.31e-03 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 38.70 E-value: 6.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 81 IGGIFFGRIGDKYGRKIVLsttiilMALSTLFIALLPTYEQI-GVWapiLLLIARMIQGFSTGGEYSGAMVYIAESSPDK 159
Cdd:cd17433 56 AGGVLGGWIVDRAGRKLSL------MLCSVPFIAGFTVITAAqNVW---MLYVGRLLTGLASGVTSLVVPVYISEIAHPR 126
|
90 100
....*....|....*....|....*..
gi 501218165 160 KRGILGSGLE----IGTLSGYIAASVI 182
Cdd:cd17433 127 VRGTLGSCVQlmvvIGIMGAYLAGLVL 153
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|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
81-201 |
9.77e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 38.28 E-value: 9.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501218165 81 IGGIFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLIARMIQGFSTGGEYSGAMVYiAESSPDKK 160
Cdd:cd17372 49 IGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNY--------MWLIILRCLVGLGLGGGPQLASWY-LEFLPAKS 119
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 501218165 161 RGILGSGLEIGTLSGyiaasvivTILTLLLTDEQMLSWGWR 201
Cdd:cd17372 120 RGTWMVLFSVFWTVG--------TIFEASLAWLVMPRLGWR 152
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