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Conserved domains on  [gi|501285555|ref|WP_012328573|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Burkholderia]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10007659)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
3-68 1.59e-27

DNA-binding transcriptional regulator, XRE family [Transcription];


:

Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 94.05  E-value: 1.59e-27
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501285555  3 IVVKLDVMLAMRKVRSKDLAAAVGITEQNLSLLKQGKVKGIRFATLEAICRYLDCQPGDLLAFSDD 68
Cdd:COG3655   2 IYVKLDELLAERGMTKKELAEATGISRATLSRLKNGKAKAVRLDTLEKICKALDCQPGDLLEYVPD 67
 
Name Accession Description Interval E-value
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
3-68 1.59e-27

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 94.05  E-value: 1.59e-27
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501285555  3 IVVKLDVMLAMRKVRSKDLAAAVGITEQNLSLLKQGKVKGIRFATLEAICRYLDCQPGDLLAFSDD 68
Cdd:COG3655   2 IYVKLDELLAERGMTKKELAEATGISRATLSRLKNGKAKAVRLDTLEKICKALDCQPGDLLEYVPD 67
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 6-68 2.56e-22

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 80.66  E-value: 2.56e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501285555   6 KLDVMLAMRKVRSKDLAAAVGITEQNLSLLKQGKVKGIRFATLEAICRYLDCQPGDLLAFSDD 68
Cdd:pfam13443  1 KLRKLMADRGISKSDLARATGISRATLSRLRKGKPKRVSLDTLDKICDALGCQPGDLLEYVPD 63
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 14-62 1.38e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 35.61  E-value: 1.38e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 501285555 14 RKVRSKDLAAAVGITEQNLSLLKQGKVKgIRFATLEAICRYLDCQPGDL 62
Cdd:cd00093  11 KGLTQEELAEKLGVSRSTISRIENGKRN-PSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
19-62 3.56e-04

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 34.80  E-value: 3.56e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 501285555   19 KDLAAAVGITEQNLSLLKQGKVKgIRFATLEAICRYLDCQPGDL 62
Cdd:smart00530 14 EELAEKLGVSRSTLSRIENGKRK-PSLETLKKLAKALGVSLDEL 56
 
Name Accession Description Interval E-value
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
3-68 1.59e-27

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 94.05  E-value: 1.59e-27
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501285555  3 IVVKLDVMLAMRKVRSKDLAAAVGITEQNLSLLKQGKVKGIRFATLEAICRYLDCQPGDLLAFSDD 68
Cdd:COG3655   2 IYVKLDELLAERGMTKKELAEATGISRATLSRLKNGKAKAVRLDTLEKICKALDCQPGDLLEYVPD 67
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 6-68 2.56e-22

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 80.66  E-value: 2.56e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501285555   6 KLDVMLAMRKVRSKDLAAAVGITEQNLSLLKQGKVKGIRFATLEAICRYLDCQPGDLLAFSDD 68
Cdd:pfam13443  1 KLRKLMADRGISKSDLARATGISRATLSRLRKGKPKRVSLDTLDKICDALGCQPGDLLEYVPD 63
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
19-68 1.01e-06

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 41.91  E-value: 1.01e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 501285555 19 KDLAAAVGITEQNLSLLKQGKVKgIRFATLEAICRYLDCQPGDLLAFSDD 68
Cdd:COG1396  24 EELAERLGVSRSTISRIERGRRN-PSLETLLKLAKALGVSLDELLGGADE 72
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
19-67 4.74e-05

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 37.13  E-value: 4.74e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 501285555 19 KDLAAAVGITEQNLSLLKQGKVKgIRFATLEAICRYLDCQPGDLLAFSD 67
Cdd:COG1476  21 EELAELLGVSRQTISAIENGKYN-PSLELALKIARALGVSLEELFSLEE 68
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 14-62 1.38e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 35.61  E-value: 1.38e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 501285555 14 RKVRSKDLAAAVGITEQNLSLLKQGKVKgIRFATLEAICRYLDCQPGDL 62
Cdd:cd00093  11 KGLTQEELAEKLGVSRSTISRIENGKRN-PSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
19-62 3.56e-04

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 34.80  E-value: 3.56e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 501285555   19 KDLAAAVGITEQNLSLLKQGKVKgIRFATLEAICRYLDCQPGDL 62
Cdd:smart00530 14 EELAEKLGVSRSTLSRIENGKRK-PSLETLKKLAKALGVSLDEL 56
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 1-69 1.90e-03

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 33.45  E-value: 1.90e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501285555  1 MTIVVKLDVMLAMRKVRSKDLAAAVGITEQNLSLLKQGKVKgIRFATLEAICRYLDCQPgDLLAFSDDG 69
Cdd:COG3620  16 DTLGEALRLMRKELGLSQLPVAELVGVSQSDILRIESGKRD-PTVSTLEKIAEALGKEL-SAVLVVDDG 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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