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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Streptomyces]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
10-139 1.32e-47

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 150.31  E-value: 1.32e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502770222  10 DATDWRILDILQREGRTGFAELARAVSMSASAVTERVRRLEEAGVIQGYAAVVDPERLGLPILAFVRLRYPHGNYKPFHD 89
Cdd:COG1522    4 DEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEFAE 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 502770222  90 LVAVTPEILEAHHVTGDDCFVIKVAARSMRHLEEV-SGRIGTL---GSVTTSVV 139
Cdd:COG1522   84 ALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFlLERLAALpgvRRTETSFV 137
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
10-139 1.32e-47

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 150.31  E-value: 1.32e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502770222  10 DATDWRILDILQREGRTGFAELARAVSMSASAVTERVRRLEEAGVIQGYAAVVDPERLGLPILAFVRLRYPHGNYKPFHD 89
Cdd:COG1522    4 DEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEFAE 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 502770222  90 LVAVTPEILEAHHVTGDDCFVIKVAARSMRHLEEV-SGRIGTL---GSVTTSVV 139
Cdd:COG1522   84 ALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFlLERLAALpgvRRTETSFV 137
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 10-115 8.08e-34

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 114.54  E-value: 8.08e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502770222    10 DATDWRILDILQREGRTGFAELARAVSMSASAVTERVRRLEEAGVIQGYAAVVDPERLGLPILAFVRLRY-PHGNYKPFH 88
Cdd:smart00344   2 DEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLeNPDKLEEFL 81

                           90       100
                   ....*....|....*....|....*..
gi 502770222    89 DLVAVTPEILEAHHVTGDDCFVIKVAA 115
Cdd:smart00344  82 EKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-118 4.24e-20

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 80.96  E-value: 4.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502770222   1 MTTQSPYEPDATDWRILDILQREGRTGFAELARAVSMSASAVTERVRRLEEAGVIQGYAAVVDPERLGLPILAFVRLRYP 80
Cdd:PRK11169   4 SKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLN 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 502770222  81 HGN---YKPFHDLVAVTPEILEAHHVTGDDCFVIKVAARSM 118
Cdd:PRK11169  84 RGApdvFEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDM 124
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
10-50 5.93e-15

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 64.31  E-value: 5.93e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 502770222   10 DATDWRILDILQREGRTGFAELARAVSMSASAVTERVRRLE 50
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-58 1.49e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 46.14  E-value: 1.49e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 502770222  10 DATDWRILDILQREGRTgFAELARAVSMSASAVTERVRRLEEAGVIQGY 58
Cdd:cd00090    6 DPTRLRILRLLLEGPLT-VSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
10-139 1.32e-47

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 150.31  E-value: 1.32e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502770222  10 DATDWRILDILQREGRTGFAELARAVSMSASAVTERVRRLEEAGVIQGYAAVVDPERLGLPILAFVRLRYPHGNYKPFHD 89
Cdd:COG1522    4 DEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEFAE 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 502770222  90 LVAVTPEILEAHHVTGDDCFVIKVAARSMRHLEEV-SGRIGTL---GSVTTSVV 139
Cdd:COG1522   84 ALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFlLERLAALpgvRRTETSFV 137
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 10-115 8.08e-34

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 114.54  E-value: 8.08e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502770222    10 DATDWRILDILQREGRTGFAELARAVSMSASAVTERVRRLEEAGVIQGYAAVVDPERLGLPILAFVRLRY-PHGNYKPFH 88
Cdd:smart00344   2 DEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLeNPDKLEEFL 81

                           90       100
                   ....*....|....*....|....*..
gi 502770222    89 DLVAVTPEILEAHHVTGDDCFVIKVAA 115
Cdd:smart00344  82 EKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-118 4.24e-20

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 80.96  E-value: 4.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502770222   1 MTTQSPYEPDATDWRILDILQREGRTGFAELARAVSMSASAVTERVRRLEEAGVIQGYAAVVDPERLGLPILAFVRLRYP 80
Cdd:PRK11169   4 SKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLN 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 502770222  81 HGN---YKPFHDLVAVTPEILEAHHVTGDDCFVIKVAARSM 118
Cdd:PRK11169  84 RGApdvFEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDM 124
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 4-124 4.09e-17

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 73.21  E-value: 4.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502770222   4 QSPYEPDATDWRILDILQREGRTGFAELARAVSMSASAVTERVRRLEEAGVIQGYAAVVDPERLGLPILAFVRLRYPH-G 82
Cdd:PRK11179   2 MENYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSaK 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 502770222  83 NYKPFHDLVAVTPEILEAHHVTGDDCFVIKVAARSMRHLEEV 124
Cdd:PRK11179  82 DYPSALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHV 123
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
10-50 5.93e-15

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 64.31  E-value: 5.93e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 502770222   10 DATDWRILDILQREGRTGFAELARAVSMSASAVTERVRRLE 50
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
12-55 5.60e-14

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 62.07  E-value: 5.60e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 502770222   12 TDWRILDILQREGRTGFAELARAVSMSASAVTERVRRLEEAGVI 55
Cdd:pfam13412   2 TDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 75-142 2.98e-13

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 61.00  E-value: 2.98e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502770222   75 VRLRYPHgNYKPFHDLVAVTPEILEAHHVTGDDCFVIKVAARSMRHLEEV-SGRIGTL---GSVTTSVVYSS 142
Cdd:pfam01037   3 VKLEPGH-ALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFlREKLRSLpgvARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-58 1.49e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 46.14  E-value: 1.49e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 502770222  10 DATDWRILDILQREGRTgFAELARAVSMSASAVTERVRRLEEAGVIQGY 58
Cdd:cd00090    6 DPTRLRILRLLLEGPLT-VSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
11-56 8.29e-07

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 44.89  E-value: 8.29e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 502770222    11 ATDWRILDILQREGRTGFAELARAVSMSASAVTERVRRLEEAGVIQ 56
Cdd:smart00347  10 PTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVR 55
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
10-58 1.65e-06

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 44.25  E-value: 1.65e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 502770222  10 DATDWRILDILQREGRTgFAELARAVSMSASAVTERVRRLEEAGVIQGY 58
Cdd:COG1777   16 NPTRRRILALLSEEPAY-VSELARELGVSRQAVYKHLRKLEEAGLVESY 63
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-56 2.61e-06

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 44.19  E-value: 2.61e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 502770222   5 SPYEPDATDWRILDILQREGRTGFAELARAVSMSASAVTERVRRLEEAGVIQ 56
Cdd:COG1846   32 AELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 11-56 1.33e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 40.61  E-value: 1.33e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 502770222   11 ATDWRILDILQREGRTGFAELARAVSMSASAVTERVRRLEEAGVIQ 56
Cdd:pfam01047   3 LTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIE 48
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
15-55 5.57e-05

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 39.12  E-value: 5.57e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 502770222    15 RILDILQREGRTgFAELARAVSMSASAVTERVRRLEEAGVI 55
Cdd:smart00418   1 KILKLLAEGELC-VCELAEILGLSQSTVSHHLKKLREAGLV 40
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
15-56 8.11e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 39.17  E-value: 8.11e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 502770222  15 RILDILQREGRTgFAELARAVSMSASAVTERVRRLEEAGVIQ 56
Cdd:COG4189   23 RILRLLAEEPLN-VNELAEALGLPKSTVSYHIRKLEEAGLIR 63
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
12-55 3.31e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 38.71  E-value: 3.31e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 502770222  12 TDWRILDILQREGRTGFAELARAVSMSASAVTERVRRLEEAGVI 55
Cdd:COG3398   98 TPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLV 141
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 10-55 6.21e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 36.03  E-value: 6.21e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 502770222   10 DATDWRILDILQREGRTGFAELARAVSMSASAVTERVRRLEEAGVI 55
Cdd:pfam12802   4 TPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLV 49
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
1-56 2.35e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 36.82  E-value: 2.35e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 502770222   1 MTTQSPY--EPDATDWRILDILQREGRTGFAELARAVSMSASAVTERVRRLEEAGVIQ 56
Cdd:COG2345    1 MTDTPALaaLADPTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVE 58
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
15-56 2.68e-03

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 35.25  E-value: 2.68e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 502770222  15 RILDILQREGRTgFAELARAVSMSASAVTERVRRLEEAGVIQ 56
Cdd:COG0640   24 RILRLLAEGELC-VGELAEALGLSQSTVSHHLKVLREAGLVT 64
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 15-55 3.65e-03

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 33.57  E-value: 3.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 502770222   15 RILDILQREGRTgFAELARAVSMSASAVTERVRRLEEAGVI 55
Cdd:pfam01022   6 KILKLLAEGELC-VCELAEELGLSQSTVSHHLKKLREAGLV 45
COG4190 COG4190
Predicted transcriptional regulator, contains HTH domain [Transcription];
14-55 4.12e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443344  Cd Length: 121  Bit Score: 35.26  E-value: 4.12e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 502770222  14 WRILDILQREGRTGFAELARAVSMSASAVTERVRRLEEAGVI 55
Cdd:COG4190   55 LELLRAIAEEGPESIRELARRLGRDVKNVHRDLKTLEELGLV 96
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 15-55 8.81e-03

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 32.90  E-value: 8.81e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 502770222   15 RILDILQREGRTGFAELARAVSMSASAVTERVRRLEEAGVI 55
Cdd:pfam12840  14 RILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLV 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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