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Conserved domains on  [gi|502964278|ref|WP_013199254|]
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MULTISPECIES: glycosyltransferase [Acinetobacter]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 4-208 1.76e-82

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd04195:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 201  Bit Score: 246.46  E-value: 1.76e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   4 SVLISIYFKEQPEHFNACMESIWNnQTVKPSEIIMVEDGPLTPELDLIIKYWEEKLKdiLKVTKLAENVGTGKAKNIGLK 83
Cdd:cd04195    1 SVLMSVYIKEKPEFLREALESILK-QTLPPDEVVLVKDGPVTQSLNEVLEEFKRKLP--LKVVPLEKNRGLGKALNEGLK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278  84 QCTNEIVCIVDTDDISVPDRFEKQIKILSGDPELVILGGQIIEFIEDISsPSGMRNVPLTNLELRQYAKKQSPFNNMTIT 163
Cdd:cd04195   78 HCTYDWVARMDTDDISLPDRFEKQLDFIEKNPEIDIVGGGVLEFDSDGN-DIGKRRLPTSHDDILKFARRRSPFNHPTVM 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 502964278 164 YRKTKILEVGGYQHHLWMEDYNLFLRVIAKGYKVQNLPDVLVYAR 208
Cdd:cd04195  157 FRKSKVLAVGGYQDLPLVEDYALWARMLANGARFANLPEILVKAR 201
 
Name Accession Description Interval E-value
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 4-208 1.76e-82

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 246.46  E-value: 1.76e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   4 SVLISIYFKEQPEHFNACMESIWNnQTVKPSEIIMVEDGPLTPELDLIIKYWEEKLKdiLKVTKLAENVGTGKAKNIGLK 83
Cdd:cd04195    1 SVLMSVYIKEKPEFLREALESILK-QTLPPDEVVLVKDGPVTQSLNEVLEEFKRKLP--LKVVPLEKNRGLGKALNEGLK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278  84 QCTNEIVCIVDTDDISVPDRFEKQIKILSGDPELVILGGQIIEFIEDISsPSGMRNVPLTNLELRQYAKKQSPFNNMTIT 163
Cdd:cd04195   78 HCTYDWVARMDTDDISLPDRFEKQLDFIEKNPEIDIVGGGVLEFDSDGN-DIGKRRLPTSHDDILKFARRRSPFNHPTVM 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 502964278 164 YRKTKILEVGGYQHHLWMEDYNLFLRVIAKGYKVQNLPDVLVYAR 208
Cdd:cd04195  157 FRKSKVLAVGGYQDLPLVEDYALWARMLANGARFANLPEILVKAR 201
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-217 1.13e-21

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 89.76  E-value: 1.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   1 MKFSVLISIYfkEQPEHFNACMESIwNNQTVKPSEIIMVEDG--PLTPEldlIIKYWEEKLKDIlKVTKLAENVGTGKAK 78
Cdd:COG0463    2 PLVSVVIPTY--NEEEYLEEALESL-LAQTYPDFEIIVVDDGstDGTAE---ILRELAAKDPRI-RVIRLERNRGKGAAR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278  79 NIGLKQCTNEIVCIVDTDDISVPDRFEKQIKILSGDPELVILGGQIIEfiediSSPSGMRNVPLTNLELRQYAKKQSPFN 158
Cdd:COG0463   75 NAGLAAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSRLIR-----EGESDLRRLGSRLFNLVRLLTNLPDST 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 502964278 159 NMTITYRKtKILEVGGYQHHlWMEDYNLfLRVIAKGYKVQNLPDvlVYARIDNGMHGRR 217
Cdd:COG0463  150 SGFRLFRR-EVLEELGFDEG-FLEDTEL-LRALRHGFRIAEVPV--RYRAGESKLNLRD 203
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 4-171 5.02e-14

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 68.19  E-value: 5.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278    4 SVLISIYFKEQPehFNACMESIwNNQTVKPSEIIMVEDGPlTPELDLIIKYWEEKLKDIlKVTKLAENVGTGKAKNIGLK 83
Cdd:pfam00535   1 SVIIPTYNEEKY--LLETLESL-LNQTYPNFEIIVVDDGS-TDGTVEIAEEYAKKDPRV-RVIRLPENRGKAGARNAGLR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   84 QCTNEIVCIVDTDDISVPDRFEKQIKILSGDPELVILGGQIIEFIED--ISSPSGMRNVPLTNLELRQYAKKQSPFNNMT 161
Cdd:pfam00535  76 AATGDYIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETgeYRRASRITLSRLPFFLGLRLLGLNLPFLIGG 155

                         170
                  ....*....|
gi 502964278  162 ITYRKTKILE 171
Cdd:pfam00535 156 FALYRREALE 165
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 2-110 2.96e-09

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 56.59  E-value: 2.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   2 KFSVLISIYFKEqpEHFNACMESIwNNQTVKPSEIIMVEDGPlTPELDLIIKYWEEKLKDILKVTKlaENVGTGKAKNIG 81
Cdd:PRK10073   7 KLSIIIPLYNAG--KDFRAFMESL-IAQTWTALEIIIVNDGS-TDNSVEIAKHYAENYPHVRLLHQ--ANAGVSVARNTG 80

                         90       100
                 ....*....|....*....|....*....
gi 502964278  82 LKQCTNEIVCIVDTDDISVPDRFEKQIKI 110
Cdd:PRK10073  81 LAVATGKYVAFPDADDVVYPTMYETLMTM 109
 
Name Accession Description Interval E-value
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 4-208 1.76e-82

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 246.46  E-value: 1.76e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   4 SVLISIYFKEQPEHFNACMESIWNnQTVKPSEIIMVEDGPLTPELDLIIKYWEEKLKdiLKVTKLAENVGTGKAKNIGLK 83
Cdd:cd04195    1 SVLMSVYIKEKPEFLREALESILK-QTLPPDEVVLVKDGPVTQSLNEVLEEFKRKLP--LKVVPLEKNRGLGKALNEGLK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278  84 QCTNEIVCIVDTDDISVPDRFEKQIKILSGDPELVILGGQIIEFIEDISsPSGMRNVPLTNLELRQYAKKQSPFNNMTIT 163
Cdd:cd04195   78 HCTYDWVARMDTDDISLPDRFEKQLDFIEKNPEIDIVGGGVLEFDSDGN-DIGKRRLPTSHDDILKFARRRSPFNHPTVM 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 502964278 164 YRKTKILEVGGYQHHLWMEDYNLFLRVIAKGYKVQNLPDVLVYAR 208
Cdd:cd04195  157 FRKSKVLAVGGYQDLPLVEDYALWARMLANGARFANLPEILVKAR 201
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-217 1.13e-21

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 89.76  E-value: 1.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   1 MKFSVLISIYfkEQPEHFNACMESIwNNQTVKPSEIIMVEDG--PLTPEldlIIKYWEEKLKDIlKVTKLAENVGTGKAK 78
Cdd:COG0463    2 PLVSVVIPTY--NEEEYLEEALESL-LAQTYPDFEIIVVDDGstDGTAE---ILRELAAKDPRI-RVIRLERNRGKGAAR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278  79 NIGLKQCTNEIVCIVDTDDISVPDRFEKQIKILSGDPELVILGGQIIEfiediSSPSGMRNVPLTNLELRQYAKKQSPFN 158
Cdd:COG0463   75 NAGLAAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSRLIR-----EGESDLRRLGSRLFNLVRLLTNLPDST 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 502964278 159 NMTITYRKtKILEVGGYQHHlWMEDYNLfLRVIAKGYKVQNLPDvlVYARIDNGMHGRR 217
Cdd:COG0463  150 SGFRLFRR-EVLEELGFDEG-FLEDTEL-LRALRHGFRIAEVPV--RYRAGESKLNLRD 203
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 1-218 1.97e-19

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 85.95  E-value: 1.97e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   1 MKFSVLISIYfKEqPEHFNACMESIwNNQTVKPS--EIIMVEDGPlTPELDLIIKYWEEKLKDIlKVTKLAENVGTGKAK 78
Cdd:COG1215   29 PRVSVIIPAY-NE-EAVIEETLRSL-LAQDYPKEklEVIVVDDGS-TDETAEIARELAAEYPRV-RVIERPENGGKAAAL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278  79 NIGLKQCTNEIVCIVDTDDISVPDRFEKQIKILSgDPELVILGGqiiefiedisspsgmrnvpltnlelrqyakkqspfn 158
Cdd:COG1215  104 NAGLKAARGDIVVFLDADTVLDPDWLRRLVAAFA-DPGVGASGA------------------------------------ 146

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278 159 nmTITYRKTKILEVGGYQHHLWMEDYNLFLRVIAKGYKVQNLPDVLVYARIDNGMHGRRK 218
Cdd:COG1215  147 --NLAFRREALEEVGGFDEDTLGEDLDLSLRLLRAGYRIVYVPDAVVYEEAPETLRALFR 204
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-206 5.41e-15

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 71.56  E-value: 5.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   1 MKFSVLISIYfkEQPEHFNACMESIWNnQTVKPSEIIMVEDGPLTPELDLIIKYWEEKLKdilkVTKLAENVGTGKAKNI 80
Cdd:COG1216    3 PKVSVVIPTY--NRPELLRRCLESLLA-QTYPPFEVIVVDNGSTDGTAELLAALAFPRVR----VIRNPENLGFAAARNL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278  81 GLKQCTNEIVCIVDTDDISVPDrfekqikilsgdpelvilggqiieFIEDISSPSGMrnvpltnlelrqyakkqspfnnm 160
Cdd:COG1216   76 GLRAAGGDYLLFLDDDTVVEPD------------------------WLERLLAAACL----------------------- 108

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 502964278 161 tiTYRKTKILEVGGY--QHHLWMEDYNLFLRVIAKGYKVQNLPDVLVY 206
Cdd:COG1216  109 --LIRREVFEEVGGFdeRFFLYGEDVDLCLRLRKAGYRIVYVPDAVVY 154
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 5-128 2.46e-14

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 68.69  E-value: 2.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   5 VLISIYFKEqpEHFNACMESIwNNQTVKPSEIIMVEDGPlTPELDLIIKYWEEKLKDILKVTKLaENVGTGKAKNIGLKQ 84
Cdd:cd00761    1 VIIPAYNEE--PYLERCLESL-LAQTYPNFEVIVVDDGS-TDGTLEILEEYAKKDPRVIRVINE-ENQGLAAARNAGLKA 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 502964278  85 CTNEIVCIVDTDDISVPDRFEKQIKILSGDPELVILGGQIIEFI 128
Cdd:cd00761   76 ARGEYILFLDADDLLLPDWLERLVAELLADPEADAVGGPGNLLF 119
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 4-171 5.02e-14

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 68.19  E-value: 5.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278    4 SVLISIYFKEQPehFNACMESIwNNQTVKPSEIIMVEDGPlTPELDLIIKYWEEKLKDIlKVTKLAENVGTGKAKNIGLK 83
Cdd:pfam00535   1 SVIIPTYNEEKY--LLETLESL-LNQTYPNFEIIVVDDGS-TDGTVEIAEEYAKKDPRV-RVIRLPENRGKAGARNAGLR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   84 QCTNEIVCIVDTDDISVPDRFEKQIKILSGDPELVILGGQIIEFIED--ISSPSGMRNVPLTNLELRQYAKKQSPFNNMT 161
Cdd:pfam00535  76 AATGDYIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETgeYRRASRITLSRLPFFLGLRLLGLNLPFLIGG 155

                         170
                  ....*....|
gi 502964278  162 ITYRKTKILE 171
Cdd:pfam00535 156 FALYRREALE 165
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 2-209 2.16e-11

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 61.45  E-value: 2.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   2 KFSVLISIYfKEQPEHFNACMESIwNNQTVKPSEIIMVEDGPLTPELDLIIKyWEEKLKDILKVTKLAENVGTGKAKNIG 81
Cdd:cd04184    2 LISIVMPVY-NTPEKYLREAIESV-RAQTYPNWELCIADDASTDPEVKRVLK-KYAAQDPRIKVVFREENGGISAATNSA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278  82 LKQCTNEIVCIVDTDDISVPDRFEKQIKILSGDPElvilggqiIEFI---EDISSPSGMRNVPLtnlelrqYAKKQSP-- 156
Cdd:cd04184   79 LELATGEFVALLDHDDELAPHALYEVVKALNEHPD--------ADLIysdEDKIDEGGKRSEPF-------FKPDWSPdl 143

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 502964278 157 -FNNMTIT----YRKTKILEVGGY-------QhhlwmeDYNLFLRVIAKGYKVQNLPDVLVYARI 209
Cdd:cd04184  144 lLSQNYIGhllvYRRSLVRQVGGFregfegaQ------DYDLVLRVSEHTDRIAHIPRVLYHWRA 202
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 7-206 1.43e-09

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 55.64  E-value: 1.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   7 ISIYFKEQPEHFNACMESIwNNQTVKPSEIIMVEDGPLTPELDLIIKYWEEklkdiLKVTKLAENVGTGKAKNIGLKQCT 86
Cdd:cd04186    1 IIIVNYNSLEYLKACLDSL-LAQTYPDFEVIVVDNASTDGSVELLRELFPE-----VRLIRNGENLGFGAGNNQGIREAK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278  87 NEIVCIVDTDDISVPDRFEKQIKILSGDPELVILGGQIiefiedisspSG---Mrnvpltnlelrqyakkqspfnnmtit 163
Cdd:cd04186   75 GDYVLLLNPDTVVEPGALLELLDAAEQDPDVGIVGPKV----------SGaflL-------------------------- 118

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 502964278 164 YRKTKILEVGGYQH--HLWMEDYNLFLRVIAKGYKVQNLPDVLVY 206
Cdd:cd04186  119 VRREVFEEVGGFDEdfFLYYEDVDLCLRARLAGYRVLYVPQAVIY 163
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 20-183 2.35e-09

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 55.31  E-value: 2.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278  20 ACMESIwNNQTVKPSEIIMVEDGPlTPELDLIIKYWEEKLKDILKVTKLAENVGTGKAKNIGLKQCTNEIVCIVDTDDIS 99
Cdd:cd06423   14 RTIESL-LALDYPKLEVIVVDDGS-TDDTLEILEELAALYIRRVLVVRDKENGGKAGALNAGLRHAKGDIVVVLDADTIL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278 100 VPDRFEKQIKILSGDPELVILGGQIIefiedisspsgMRNVPLTNLELRQYA----------KKQSPFNNMTI------T 163
Cdd:cd06423   92 EPDALKRLVVPFFADPKVGAVQGRVR-----------VRNGSENLLTRLQAIeylsifrlgrRAQSALGGVLVlsgafgA 160

                        170       180
                 ....*....|....*....|
gi 502964278 164 YRKTKILEVGGYQHHLWMED 183
Cdd:cd06423  161 FRREALREVGGWDEDTLTED 180
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 2-110 2.96e-09

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 56.59  E-value: 2.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   2 KFSVLISIYFKEqpEHFNACMESIwNNQTVKPSEIIMVEDGPlTPELDLIIKYWEEKLKDILKVTKlaENVGTGKAKNIG 81
Cdd:PRK10073   7 KLSIIIPLYNAG--KDFRAFMESL-IAQTWTALEIIIVNDGS-TDNSVEIAKHYAENYPHVRLLHQ--ANAGVSVARNTG 80

                         90       100
                 ....*....|....*....|....*....
gi 502964278  82 LKQCTNEIVCIVDTDDISVPDRFEKQIKI 110
Cdd:PRK10073  81 LAVATGKYVAFPDADDVVYPTMYETLMTM 109
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 5-130 2.05e-07

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 50.53  E-value: 2.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   5 VLISIYFKEQpeHFNACMESIWNNQTVKPSEIIMVEDGPlTPELDLIIKYWEEKLKDILKVTKLAEN-----VGTGKAKN 79
Cdd:cd06913    1 IILPVHNGEQ--WLDECLESVLQQDFEGTLELSVFNDAS-TDKSAEIIEKWRKKLEDSGVIVLVGSHnspspKGVGYAKN 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 502964278  80 IGLKQCTNEIVCIVDTDDISVPDRFEKQIKILSGDPeLVILGGQIIEFIED 130
Cdd:cd06913   78 QAIAQSSGRYLCFLDSDDVMMPQRIRLQYEAALQHP-NSIIGCQVRRIPED 127
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 20-210 5.93e-07

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 48.70  E-value: 5.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278  20 ACMESIWNnQTVKPSEIIMVeDGPLTPE-LDlIIKYWEEKL------KDIlkvtklaenvGTGKAKNIGLKQCTNEIVCI 92
Cdd:cd06433   15 ETIDSVLS-QTYPNIEYIVI-DGGSTDGtVD-IIKKYEDKItywisePDK----------GIYDAMNKGIALATGDIIGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278  93 VDTDDISVPDRFEKQIKILSGDPELVILGGQIIEFIEDISSPSGMRNVPLTNLELRQYAkkqsPFNNMTITYRKTKILEV 172
Cdd:cd06433   82 LNSDDTLLPGALLAVVAAFAEHPEVDVVYGDVLLVDENGRVIGRRRPPPFLDKFLLYGM----PICHQATFFRRSLFEKY 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 502964278 173 GGY--QHHLWMeDYNLFLRVIAKGYKVQNLPDVLVYARID 210
Cdd:cd06433  158 GGFdeSYRIAA-DYDLLLRLLLAGKIFKYLPEVLAAFRLG 196
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 2-208 7.19e-07

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 49.15  E-value: 7.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   2 KFSVLISIYFKEQpeHFNACMESIWNNQTVKPS-EIIMVeDGPLTPELDLIIKYWEEKLKDIlkvtKLAENVG--TGKAK 78
Cdd:cd02525    1 FVSIIIPVRNEEK--YIEELLESLLNQSYPKDLiEIIVV-DGGSTDGTREIVQEYAAKDPRI----RLIDNPKriQSAGL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278  79 NIGLKQCTNEIVCIVDTDDISVPDRFEKQIKILsGDPELVILGG-----------QIIEFIEdiSSPSGMRNVPLtnlel 147
Cdd:cd02525   74 NIGIRNSRGDIIIRVDAHAVYPKDYILELVEAL-KRTGADNVGGpmetigeskfqKAIAVAQ--SSPLGSGGSAY----- 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 502964278 148 RQYAKKQSP----FNNMtitYRKTKILEVGGYQHHLWM-EDYNLFLRVIAKGYKVQNLPDVLVYAR 208
Cdd:cd02525  146 RGGAVKIGYvdtvHHGA---YRREVFEKVGGFDESLVRnEDAELNYRLRKAGYKIWLSPDIRVYYY 208
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 10-216 1.93e-06

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 47.63  E-value: 1.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278  10 YFKEQpehfnacMESIwNNQTVKPSEIIMVEDGPLTPELDlIIKYWEEKLKDILKVTKLAENVGTGKAKNIGLKQCTNEI 89
Cdd:cd04196   12 YLREQ-------LDSI-LAQTYKNDELIISDDGSTDGTVE-IIKEYIDKDPFIIILIRNGKNLGVARNFESLLQAADGDY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278  90 VCIVDTDDISVPDRFEKQIKILSGD--PELVILGGQIIEFIEDISSPSGMRNVPLTNLELRQYAKKQSPFNNMTITYRK- 166
Cdd:cd04196   83 VFFCDQDDIWLPDKLERLLKAFLKDdkPLLVYSDLELVDENGNPIGESFFEYQKIKPGTSFNNLLFQNVVTGCTMAFNRe 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 502964278 167 --TKILEVGGYQHhlWMEDYnlFLRVIAKGY-KVQNLPDVLVYARIdngmHGR 216
Cdd:cd04196  163 llELALPFPDADV--IMHDW--WLALLASAFgKVVFLDEPLILYRQ----HGN 207
GT2_HAS cd06434
Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are ...
 4-124 1.29e-05

Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are bi-functional glycosyltransferases that catalyze polymerization of hyaluronan. HASs transfer both GlcUA and GlcNAc in beta-(1,3) and beta-(1,4) linkages, respectively to the hyaluronan chain using UDP-GlcNAc and UDP-GlcUA as substrates. HA is made as a free glycan, not attached to a protein or lipid. HASs do not need a primer for HA synthesis; they initiate HA biosynthesis de novo with only UDP-GlcNAc, UDP-GlcUA, and Mg2+. Hyaluronan (HA) is a linear heteropolysaccharide composed of (1-3)-linked beta-D-GlcUA-beta-D-GlcNAc disaccharide repeats. It can be found in vertebrates and a few microbes and is typically on the cell surface or in the extracellular space, but is also found inside mammalian cells. Hyaluronan has several physiochemical and biological functions such as space filling, lubrication, and providing a hydrated matrix through which cells can migrate.


Pssm-ID: 133056 [Multi-domain]  Cd Length: 235  Bit Score: 45.32  E-value: 1.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   4 SVLISIYfKEQPEHFNACMESIWNNQtvkPSEIIMVEDGPLTPELDLIikywEEKLKDILKVTKLAENVGTGKAKNIGLK 83
Cdd:cd06434    3 TVIIPVY-DEDPDVFRECLRSILRQK---PLEIIVVTDGDDEPYLSIL----SQTVKYGGIFVITVPHPGKRRALAEGIR 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 502964278  84 QCTNEIVCIVDtDDISVPDRFEKQIKILSGDPELVILGGQI 124
Cdd:cd06434   75 HVTTDIVVLLD-SDTVWPPNALPEMLKPFEDPKVGGVGTNQ 114
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 35-206 4.78e-05

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 43.80  E-value: 4.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278   35 EIIMVEDGPLTPELDLIIKYWEEKLKDILKvTKLAENVGTGKAKNIGLKQCTNEIVCIVDTDDISVPDRFEKQIKILsgd 114
Cdd:pfam10111  31 ELIIINDGSTDKTLEEVSSIKDHNLQVYYP-NAPDTTYSLAASRNRGTSHAIGEYISFIDGDCLWSPDKFEKQLKIA--- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278  115 pelvilggQIIEFIEDISSPSGMRNVPL---TNLELRQYAKK-------------QSPF------NNMTITYRKTKILEV 172
Cdd:pfam10111 107 --------TSLALQENIQAAVVLPVTDLndeSSNFLRRGGDLtasgdvlrdllvfYSPLaiffapNSSNALINRQAFIEV 178

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 502964278  173 GGYQHHLW---MEDYNLFLRVIAKGYKVQNLPDVLVY 206
Cdd:pfam10111 179 GGFDESFRghgAEDFDIFLRLAARYPFVAVMPPQLLY 215
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 35-202 1.32e-04

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 42.28  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278  35 EIIMVEDGPlTPELDLIIKYWEEKLKDILKVTKLAENVGTGKAKNI--GLKQCTNEIVCIVDTDDISVPD--------RF 104
Cdd:cd04192   30 EVILVDDHS-TDGTVQILEFAAAKPNFQLKILNNSRVSISGKKNALttAIKAAKGDWIVTTDADCVVPSNwlltfvafIQ 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502964278 105 EKQIKILSGdPELVILGGQ-IIEFIE-DISSPSGMRNVpltnlelrqYAKKQSPF----NNMTitYRKTKILEVGGY-QH 177
Cdd:cd04192  109 KEQIGLVAG-PVIYFKGKSlLAKFQRlDWLSLLGLIAG---------SFGLGKPFmcngANMA--YRKEAFFEVGGFeGN 176

                        170       180
                 ....*....|....*....|....*..
gi 502964278 178 -HLWMEDYNLFLRVIAKGY-KVQNLPD 202
Cdd:cd04192  177 dHIASGDDELLLAKVASKYpKVAYLKN 203
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 35-111 1.57e-03

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 39.37  E-value: 1.57e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502964278  35 EIIMVEDGPLTPELDLIIKYWEEKLKDI--LKVTKLAENVGTGKAKNIGLKQCTNEIVCIVDTDDISVPDRFEKQIKIL 111
Cdd:PTZ00260 109 EIIIVNDGSKDKTLKVAKDFWRQNINPNidIRLLSLLRNKGKGGAVRIGMLASRGKYILMVDADGATDIDDFDKLEDIM 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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