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Conserved domains on  [gi|515629009|ref|WP_017061609|]
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MULTISPECIES: GntR family transcriptional regulator [Vibrio]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
13-221 1.62e-55

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 177.04  E-value: 1.62e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009  13 KTKVTGQTQDDVVYCHIFDAILEQRLPPATKLSEEALAEIFSVSRTIIRRALLRLSLEQVVVIRPNRGAVIAAPTVDEAK 92
Cdd:COG1802    4 PSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009  93 QIFKAREVMEIAITELAVKNATKAQIEECRKLVAKENCAFDQGDYGSGLRLSGEFHIKLAEMAENAPLLAFQRSLVSQTS 172
Cdd:COG1802   84 ELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLR 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 515629009 173 LLIAQ-YETGNHSNCSLDEHSGLLDAIESGNEQQAVELMQEHLSHIRSKL 221
Cdd:COG1802  164 RYRRLsLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERL 213
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
13-221 1.62e-55

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 177.04  E-value: 1.62e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009  13 KTKVTGQTQDDVVYCHIFDAILEQRLPPATKLSEEALAEIFSVSRTIIRRALLRLSLEQVVVIRPNRGAVIAAPTVDEAK 92
Cdd:COG1802    4 PSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009  93 QIFKAREVMEIAITELAVKNATKAQIEECRKLVAKENCAFDQGDYGSGLRLSGEFHIKLAEMAENAPLLAFQRSLVSQTS 172
Cdd:COG1802   84 ELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLR 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 515629009 173 LLIAQ-YETGNHSNCSLDEHSGLLDAIESGNEQQAVELMQEHLSHIRSKL 221
Cdd:COG1802  164 RYRRLsLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERL 213
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 93-216 1.01e-20

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 84.33  E-value: 1.01e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009    93 QIFKAREVMEIAITELAVKNATKAQIEECRKLVAKENCAFDQGDYGSGL-RLSGEFHIKLAEMAENAPLLAFQRSLVSQT 171
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGDDLEEFaELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 515629009   172 SLLIAQYETGNHSncSLDEHSGLLDAIESGNEQQAVELMQEHLSH 216
Cdd:smart00895  81 RRLRRLSLEAARR--ALDEHRAILDAIRARDAEAARAAMREHLEA 123
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 93-212 4.60e-17

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 74.71  E-value: 4.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009   93 QIFKAREVMEIAITELAVKNATKAQIEECRKLVAKENCAFDQGDYGSGLRLSGEFHIKLAEMAENAPLLAFQRSLVSQTS 172
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 515629009  173 LLIAQYETGNHSN-CSLDEHSGLLDAIESGNEQQAVELMQE 212
Cdd:pfam07729  81 RLRRLLLSSPGRLrASLEEHRAILDAIRARDPEAARAAMRR 121
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 32-220 1.35e-14

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 70.82  E-value: 1.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009  32 AILEQR-LPPATKL-SEEALAEIFSVSRTIIRRALLRLSL---------EQVVVIRPNRGAVIAapTVDEAKQIF----- 95
Cdd:PRK03837  24 QMIRSGeFGPGDQLpSERELMAFFGVGRPAVREALQALKRkglvqishgERARVSRPSADTIIG--QLSGMAKDFlsqsp 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009  96 -------KAREVMEIAITELAVKNATKAQIEECRKLVAKENCAFdqGDYGSGLRLSGEFHIKLAEMAENAPLLAFQRSLV 168
Cdd:PRK03837 102 dglahlkQARLFFESSLARYAAEHATDEQIALLRKALERNSQSL--GDNAAFIRSDMEFHRVIAEIPGNPIFMAIHEALL 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 515629009 169 SqtsLLIAQY----ETGNHSNCSLDEHSGLLDAIESGNEQQAVELMQEHLSHIRSK 220
Cdd:PRK03837 180 D---WLIEARpevvILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLNRVSAL 232
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 23-84 6.16e-13

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 62.08  E-value: 6.16e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515629009  23 DVVYCHIFDAILEQRLPPATKL-SEEALAEIFSVSRTIIRRALLRLSLEQVVVIRPNRGAVIA 84
Cdd:cd07377    4 EQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
13-221 1.62e-55

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 177.04  E-value: 1.62e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009  13 KTKVTGQTQDDVVYCHIFDAILEQRLPPATKLSEEALAEIFSVSRTIIRRALLRLSLEQVVVIRPNRGAVIAAPTVDEAK 92
Cdd:COG1802    4 PSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009  93 QIFKAREVMEIAITELAVKNATKAQIEECRKLVAKENCAFDQGDYGSGLRLSGEFHIKLAEMAENAPLLAFQRSLVSQTS 172
Cdd:COG1802   84 ELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLR 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 515629009 173 LLIAQ-YETGNHSNCSLDEHSGLLDAIESGNEQQAVELMQEHLSHIRSKL 221
Cdd:COG1802  164 RYRRLsLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERL 213
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
28-221 4.62e-35

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 124.66  E-value: 4.62e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009  28 HIFDAILEQRLPPATKL-SEEALAEIFSVSRTIIRRALLRLSLEQVVVIRPNRGAVIAAPTVDEA--------------- 91
Cdd:COG2186   15 QLRELILSGELKPGDRLpSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALldplalllalddasl 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009  92 KQIFKAREVMEIAITELAVKNATKAQIEECRKLVAK-ENCAFDQGDYgsgLRLSGEFHIKLAEMAENAPLLAFQRSLVSQ 170
Cdd:COG2186   95 RDLLEARLALEPEAARLAAERATDEDLARLEAALAEmEAAADDGEAF---AEADLAFHRAIAEASGNPLLALLLESLREL 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 515629009 171 -TSLLIAQYETGNHSNCSLDEHSGLLDAIESGNEQQAVELMQEHLSHIRSKL 221
Cdd:COG2186  172 lRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERL 223
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 93-216 1.01e-20

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 84.33  E-value: 1.01e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009    93 QIFKAREVMEIAITELAVKNATKAQIEECRKLVAKENCAFDQGDYGSGL-RLSGEFHIKLAEMAENAPLLAFQRSLVSQT 171
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGDDLEEFaELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 515629009   172 SLLIAQYETGNHSncSLDEHSGLLDAIESGNEQQAVELMQEHLSH 216
Cdd:smart00895  81 RRLRRLSLEAARR--ALDEHRAILDAIRARDAEAARAAMREHLEA 123
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 93-212 4.60e-17

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 74.71  E-value: 4.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009   93 QIFKAREVMEIAITELAVKNATKAQIEECRKLVAKENCAFDQGDYGSGLRLSGEFHIKLAEMAENAPLLAFQRSLVSQTS 172
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 515629009  173 LLIAQYETGNHSN-CSLDEHSGLLDAIESGNEQQAVELMQE 212
Cdd:pfam07729  81 RLRRLLLSSPGRLrASLEEHRAILDAIRARDPEAARAAMRR 121
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 32-220 1.35e-14

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 70.82  E-value: 1.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009  32 AILEQR-LPPATKL-SEEALAEIFSVSRTIIRRALLRLSL---------EQVVVIRPNRGAVIAapTVDEAKQIF----- 95
Cdd:PRK03837  24 QMIRSGeFGPGDQLpSERELMAFFGVGRPAVREALQALKRkglvqishgERARVSRPSADTIIG--QLSGMAKDFlsqsp 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009  96 -------KAREVMEIAITELAVKNATKAQIEECRKLVAKENCAFdqGDYGSGLRLSGEFHIKLAEMAENAPLLAFQRSLV 168
Cdd:PRK03837 102 dglahlkQARLFFESSLARYAAEHATDEQIALLRKALERNSQSL--GDNAAFIRSDMEFHRVIAEIPGNPIFMAIHEALL 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 515629009 169 SqtsLLIAQY----ETGNHSNCSLDEHSGLLDAIESGNEQQAVELMQEHLSHIRSK 220
Cdd:PRK03837 180 D---WLIEARpevvILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLNRVSAL 232
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 23-84 6.16e-13

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 62.08  E-value: 6.16e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515629009  23 DVVYCHIFDAILEQRLPPATKL-SEEALAEIFSVSRTIIRRALLRLSLEQVVVIRPNRGAVIA 84
Cdd:cd07377    4 EQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 33-221 1.06e-12

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 65.56  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009  33 ILEQRLPPATKL-SEEALAEIFSVSRTIIRRALLRLSLEQVVVIRPNRGAVIAAPTVDEAKQ------------------ 93
Cdd:PRK10421  15 IEEKNLEAGMKLpAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHETWSEQnivqplktlmaddpdysf 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009  94 -IFKAREVMEIAITELAVKNAT---KAQIEECrklvakencaFD---QGDYGSGLRLSGEFHIKLAEMAENAPLLAFQRS 166
Cdd:PRK10421  95 dILEARHAIEASTAWHAAMRATpgdKEKIQLC----------FEatlSEDPDLASQADVRFHLAIAEASHNVVLLQTMRG 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515629009 167 L--VSQTSLLIAQYETGNHSNcSLDE----HSGLLDAIESGNEQQAVELMQEHLSHIRSKL 221
Cdd:PRK10421 165 FfdVLQSSVKQSRQRMYLVPP-VFSQlteqHQAVMDAILAGDAEGARKAMMAHLSFVHTTI 224
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 25-83 1.22e-12

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 61.09  E-value: 1.22e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009   25 VYCHIFDAILEQRLPPATKL-SEEALAEIFSVSRTIIRRALLRLSLEQVVVIRPNRGAVI 83
Cdd:pfam00392   5 VYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK10225 PRK10225
Uxu operon transcriptional regulator;
36-221 2.24e-10

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 59.26  E-value: 2.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009  36 QRLPPatklsEEALAEIFSVSRTIIRRALLRLSLEQVVVIRpnRGA---VIAAPTVDEAK-------------QIFKARE 99
Cdd:PRK10225  31 ERLPP-----EREIAEMLDVTRTVVREALIMLEIKGLVEVR--RGAgiyVLDSSGSHNTDspdanvcndagpfELLQARQ 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009 100 VMEIAITELAVKNATKAQIEECRKLVAKE-----NCAFDQGDYGsglrlSGEFHIKLAEMAENAPLLA-FQRSLvsqtsl 173
Cdd:PRK10225 104 LLESNIAEFAALQATREDIVKMRQALQLEerelaSSAPGSSESG-----DMQFHLAIAEATHNSMLVElFRQSW------ 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515629009 174 liaQYETGN------HSNCS--------LDEHSGLLDAIESGNEQQAVELMQEHLSHIRSKL 221
Cdd:PRK10225 173 ---QWRENNpmwiqlHSHLDdslyrkewLGDHKQILAALIKKDARAAKLAMWQHLENVKQRL 231
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
25-83 2.95e-10

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 54.50  E-value: 2.95e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009    25 VYCHIFDAILEQRLPPATKL-SEEALAEIFSVSRTIIRRALLRLSLEQVVVIRPNRGAVI 83
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
28-91 1.11e-09

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 56.79  E-value: 1.11e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515629009  28 HIFDAILEQRLPPATKL-SEEALAEIFSVSRTIIRRALLRLSLEQVVVIRPNRGAVIAAPTVDEA 91
Cdd:COG2188   13 ALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYP 77
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 25-86 5.91e-05

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 43.66  E-value: 5.91e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515629009  25 VYCHIFDAILEQRLPPATKL-SEEALAEIFSVSRTIIRRALLRLSLEQVVVIRPNRGAVIAAP 86
Cdd:COG1167   17 LADALREAILSGRLPPGDRLpSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAAR 79
PRK11414 PRK11414
GntR family transcriptional regulator;
38-136 3.37e-03

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 37.54  E-value: 3.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629009  38 LPPATKLSEEALAEIFSVSRTIIRRALLRLSLEQVVVIRPNRGAVIAAPTVDEAKQIFKAREVMEIAITELAVKNATKAQ 117
Cdd:PRK11414  29 LKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSKRQLDEINRIRYELELMAVALAVENLTPQD 108

                         90
                 ....*....|....*....
gi 515629009 118 IEECRKLVAKENCAFDQGD 136
Cdd:PRK11414 109 LAELQELLEKLQQAQEKGD 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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