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Conserved domains on  [gi|515927360|ref|WP_017357943|]
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MULTISPECIES: PTS lactose/cellobiose transporter subunit IIA [Bacillus]

Protein Classification

PTS lactose/cellobiose transporter subunit IIA( domain architecture ID 10491527)

PTS lactose/cellobiose transporter subunit IIA helps catalyze the phosphorylation of incoming sugar substrates leading to their translocation across the cell membrane; similar to Bacillus subtilis Lichenan-specific phosphotransferase enzyme IIA component

CATH:  1.20.58.280
Gene Ontology:  GO:0009401|GO:0016740
SCOP:  3001316
TCDB:  4.A.3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTS_IIA pfam02255
PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar ...
 13-102 4.35e-34

PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


:

Pssm-ID: 460510  Cd Length: 94  Bit Score: 112.91  E-value: 4.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927360   13 QISFQLILHSGNARSKLLQSLKQFREGHETVASDLLKEAEDDLRNAHDIHFQMVQQEASGETISFSLLLMHAEDHFMSTM 92
Cdd:pfam02255   1 EIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKAQTELIQKEAGGEKVEVSLLLVHAQDHLMTAM 80

                          90
                  ....*....|
gi 515927360   93 TIKELVGELL 102
Cdd:pfam02255  81 TEKDLAKELI 90
 
Name Accession Description Interval E-value
PTS_IIA pfam02255
PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar ...
 13-102 4.35e-34

PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 460510  Cd Length: 94  Bit Score: 112.91  E-value: 4.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927360   13 QISFQLILHSGNARSKLLQSLKQFREGHETVASDLLKEAEDDLRNAHDIHFQMVQQEASGETISFSLLLMHAEDHFMSTM 92
Cdd:pfam02255   1 EIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKAQTELIQKEAGGEKVEVSLLLVHAQDHLMTAM 80

                          90
                  ....*....|
gi 515927360   93 TIKELVGELL 102
Cdd:pfam02255  81 TEKDLAKELI 90
CelC COG1447
Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and ...
 12-110 1.10e-32

Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 441056  Cd Length: 100  Bit Score: 109.84  E-value: 1.10e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927360  12 EQISFQLILHSGNARSKLLQSLKQFREGHETVASDLLKEAEDDLRNAHDIHFQMVQQEASGETISFSLLLMHAEDHFMST 91
Cdd:COG1447    1 EEIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKVQTELIQKEAGGEKVEVSLLLVHAQDHLMTA 80

                         90
                 ....*....|....*....
gi 515927360  92 MTIKELVGELLPILQSLKQ 110
Cdd:COG1447   81 MTEKDLAKELIELYKKLEK 99
PTS_IIA_lac cd00215
PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial ...
 12-102 1.58e-32

PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 238133  Cd Length: 97  Bit Score: 109.22  E-value: 1.58e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927360  12 EQISFQLILHSGNARSKLLQSLKQFREGHETVASDLLKEAEDDLRNAHDIHFQMVQQEASGETISFSLLLMHAEDHFMST 91
Cdd:cd00215    2 ELISFQIILHAGNARSKALEALKAAKEGDFAEAEELLEEANDSLNEAHHAQTKLLQQEASGEKVEVSLLLVHAQDHLMTT 81

                         90
                 ....*....|.
gi 515927360  92 MTIKELVGELL 102
Cdd:cd00215   82 ITLKDLAKEMI 92
celC PRK09591
PTS cellobiose transporter subunit IIA;
14-109 3.33e-16

PTS cellobiose transporter subunit IIA;


Pssm-ID: 181975  Cd Length: 104  Bit Score: 67.90  E-value: 3.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927360  14 ISFQLILHSGNARSKLLQSLKQFREGHETVASDLLKEAEDDLRNAHDIHFQMVQQEASGETISFSLLLMHAEDHFMSTMT 93
Cdd:PRK09591   9 AAFEIILHSGNARTEVHEAFAAMREGNFDLAEQKLNQSNEELLEAHHAQTKLLQEYASGTEIKIEIIMVHAQDHLMTTMT 88

                         90
                 ....*....|....*.
gi 515927360  94 IKELVGELLPILQSLK 109
Cdd:PRK09591  89 LREVAKEMLALYKKVN 104
 
Name Accession Description Interval E-value
PTS_IIA pfam02255
PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar ...
 13-102 4.35e-34

PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 460510  Cd Length: 94  Bit Score: 112.91  E-value: 4.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927360   13 QISFQLILHSGNARSKLLQSLKQFREGHETVASDLLKEAEDDLRNAHDIHFQMVQQEASGETISFSLLLMHAEDHFMSTM 92
Cdd:pfam02255   1 EIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKAQTELIQKEAGGEKVEVSLLLVHAQDHLMTAM 80

                          90
                  ....*....|
gi 515927360   93 TIKELVGELL 102
Cdd:pfam02255  81 TEKDLAKELI 90
CelC COG1447
Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and ...
 12-110 1.10e-32

Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 441056  Cd Length: 100  Bit Score: 109.84  E-value: 1.10e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927360  12 EQISFQLILHSGNARSKLLQSLKQFREGHETVASDLLKEAEDDLRNAHDIHFQMVQQEASGETISFSLLLMHAEDHFMST 91
Cdd:COG1447    1 EEIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKVQTELIQKEAGGEKVEVSLLLVHAQDHLMTA 80

                         90
                 ....*....|....*....
gi 515927360  92 MTIKELVGELLPILQSLKQ 110
Cdd:COG1447   81 MTEKDLAKELIELYKKLEK 99
PTS_IIA_lac cd00215
PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial ...
 12-102 1.58e-32

PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 238133  Cd Length: 97  Bit Score: 109.22  E-value: 1.58e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927360  12 EQISFQLILHSGNARSKLLQSLKQFREGHETVASDLLKEAEDDLRNAHDIHFQMVQQEASGETISFSLLLMHAEDHFMST 91
Cdd:cd00215    2 ELISFQIILHAGNARSKALEALKAAKEGDFAEAEELLEEANDSLNEAHHAQTKLLQQEASGEKVEVSLLLVHAQDHLMTT 81

                         90
                 ....*....|.
gi 515927360  92 MTIKELVGELL 102
Cdd:cd00215   82 ITLKDLAKEMI 92
celC PRK09591
PTS cellobiose transporter subunit IIA;
14-109 3.33e-16

PTS cellobiose transporter subunit IIA;


Pssm-ID: 181975  Cd Length: 104  Bit Score: 67.90  E-value: 3.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927360  14 ISFQLILHSGNARSKLLQSLKQFREGHETVASDLLKEAEDDLRNAHDIHFQMVQQEASGETISFSLLLMHAEDHFMSTMT 93
Cdd:PRK09591   9 AAFEIILHSGNARTEVHEAFAAMREGNFDLAEQKLNQSNEELLEAHHAQTKLLQEYASGTEIKIEIIMVHAQDHLMTTMT 88

                         90
                 ....*....|....*.
gi 515927360  94 IKELVGELLPILQSLK 109
Cdd:PRK09591  89 LREVAKEMLALYKKVN 104
PRK10454 PRK10454
PTS N,N'-diacetylchitobiose transporter subunit IIA;
12-109 2.56e-11

PTS N,N'-diacetylchitobiose transporter subunit IIA;


Pssm-ID: 182472  Cd Length: 115  Bit Score: 55.67  E-value: 2.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927360  12 EQISFQLILHSGNARSKLLQSLKQFREGHETVASDLLKEAEDDLRNAHDIHFQMVQQEASGETISFSLLLMHAEDHFMST 91
Cdd:PRK10454  18 EEVVMGLIINSGQARSLAYAALKQAKQGDFAAAKAMMDQSRMALNEAHLVQTKLIEGDQGEGKMKVSLVLVHAQDHLMTS 97

                         90
                 ....*....|....*...
gi 515927360  92 MTIKELVGELLPILQSLK 109
Cdd:PRK10454  98 MLARELITELIELHEKLK 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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