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Conserved domains on  [gi|516233887|ref|WP_017637850|]
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MULTISPECIES: low molecular weight protein-tyrosine-phosphatase [Staphylococcus]

Protein Classification

low molecular weight protein-tyrosine-phosphatase( domain architecture ID 11611401)

low molecular weight protein-tyrosine-phosphatase is a small soluble single-domain enzyme that catalyzes the dephosphorylation of O-phosphotyrosine groups in phosphoproteins

EC:  3.1.3.48
Gene Ontology:  GO:0004725|GO:0006470
PubMed:  12678841|12882518|27676368
SCOP:  4000436

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 4-143 1.33e-63

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


:

Pssm-ID: 319971  Cd Length: 147  Bit Score: 191.50  E-value: 1.33e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233887   4 VAFVCLGNICRSPMAEAIMRQRLQDRGITGVKVHSRGTGKWNLGEPPHEGTQKILNTHGIPFDGMISELFEPTD--DFDY 81
Cdd:cd16343    3 ILFVCLGNICRSPMAEAVLRHLLPKAGGDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDLSGHRARQLTAEDfdEFDL 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516233887  82 IIAMDQSNVENIKAINPS-IKGQLFKLLEFSNMKESDVPDPYYTN--NFEGVYKMVQSSCDNLID 143
Cdd:cd16343   83 ILAMDESNLRDLRRLAPAeARGKVFLLGDFDPEGGKDVPDPYYGGreGFEEVYDLIERACEGLLE 147
 
Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 4-143 1.33e-63

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 191.50  E-value: 1.33e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233887   4 VAFVCLGNICRSPMAEAIMRQRLQDRGITGVKVHSRGTGKWNLGEPPHEGTQKILNTHGIPFDGMISELFEPTD--DFDY 81
Cdd:cd16343    3 ILFVCLGNICRSPMAEAVLRHLLPKAGGDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDLSGHRARQLTAEDfdEFDL 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516233887  82 IIAMDQSNVENIKAINPS-IKGQLFKLLEFSNMKESDVPDPYYTN--NFEGVYKMVQSSCDNLID 143
Cdd:cd16343   83 ILAMDESNLRDLRRLAPAeARGKVFLLGDFDPEGGKDVPDPYYGGreGFEEVYDLIERACEGLLE 147
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
1-145 1.07e-40

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 132.98  E-value: 1.07e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233887   1 MVDVAFVCLGNICRSPMAEAIMRQRLQDRgitgVKVHSRGTGKwnlGEPPHEGTQKILNTHGIPFDGMISELFEPTD--D 78
Cdd:COG0394    3 PKRVLFVCTGNICRSPMAEALLRHLAGGR----VEVDSAGTEP---GGPVDPRAVAVLAERGIDLSGHRSRQLDEEDlpE 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516233887  79 FDYIIAMDQSNVENIKAINPsikGQLFKLLEFsnmkesDVPDPYYTN--NFEGVYKMVQSSCDNLIDYI 145
Cdd:COG0394   76 FDLVITMCDSAAEELCPLFP---GAAKLLLHW------DVPDPYYGGleAFREVRDEIERRIEALLAKL 135
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
4-141 1.17e-40

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 133.27  E-value: 1.17e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233887    4 VAFVCLGNICRSPMAEAIMRQRLQDRGI-TGVKVHSRGTGKWnLGEPPHEGTQKILNTHGIPFDGMISELF--EPTDDFD 80
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGLgDKVEVDSAGTGAW-PGNPADPRAVEVLKEHGIDLSGHYARQLstEDFASFD 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516233887   81 YIIAMDQSNVENIKAINPSI-KGQLFKLLEFSNMKesDVPDPYYTN--NFEGVYKMVQSSCDNL 141
Cdd:pfam01451  80 LILAMDSEHKRDLCPLAPERyRAKVMLLGEYGEQL--DIPDPYYGSidAFEEVRDLIERRCRQL 141
LMWPc smart00226
Low molecular weight phosphatase family;
4-142 4.59e-33

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 113.72  E-value: 4.59e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233887     4 VAFVCLGNICRSPMAEAIMRQRLQDRgitgVKVHSRGTGKWnLGEPPHEGTQKILNTHGIPFDGMISELFEPT-DDFDYI 82
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYVGDR----VKIDSAGTGAW-VGGGADPRAVKVLKEHGIDLSHHASQLTSSDfKNADLV 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516233887    83 IAMDQSNVENIKAINPSIKGQLFKLLEFsnmkeSDVPDPYY--TNNFEGVYKMVQSSCDNLI 142
Cdd:smart00226  76 LAMDGSHLRNICRLKPPSRAKVELFGHY-----VDVDDPYYggIDGFERVYDELENALQEFL 132
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 7-135 4.14e-19

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 78.14  E-value: 4.14e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233887   7 VCLGNICRSPMAEAIMRQRLqdrgiTGVKVHSRGTGKWnLGEPPHEGTQKILNTHGIPFDGMISE--LFEPTDDFDYIIA 84
Cdd:PRK11391   8 VCTGNICRSPIGERLLRKRL-----PGVKVKSAGVHGL-VKHPADATAADVAANHGVSLEGHAGRklTAEMARNYDLILA 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 516233887  85 MDQSNVENIKAINPSIKGQlfKLLEFSNMKESDVPDPYYTNN--FEGVYKMVQ 135
Cdd:PRK11391  82 MESEHIAQVTAIAPEVRGK--TMLFGQWLEQKEIPDPYRKSQdaFEHVYGMLE 132
 
Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 4-143 1.33e-63

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 191.50  E-value: 1.33e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233887   4 VAFVCLGNICRSPMAEAIMRQRLQDRGITGVKVHSRGTGKWNLGEPPHEGTQKILNTHGIPFDGMISELFEPTD--DFDY 81
Cdd:cd16343    3 ILFVCLGNICRSPMAEAVLRHLLPKAGGDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDLSGHRARQLTAEDfdEFDL 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516233887  82 IIAMDQSNVENIKAINPS-IKGQLFKLLEFSNMKESDVPDPYYTN--NFEGVYKMVQSSCDNLID 143
Cdd:cd16343   83 ILAMDESNLRDLRRLAPAeARGKVFLLGDFDPEGGKDVPDPYYGGreGFEEVYDLIERACEGLLE 147
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
1-145 1.07e-40

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 132.98  E-value: 1.07e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233887   1 MVDVAFVCLGNICRSPMAEAIMRQRLQDRgitgVKVHSRGTGKwnlGEPPHEGTQKILNTHGIPFDGMISELFEPTD--D 78
Cdd:COG0394    3 PKRVLFVCTGNICRSPMAEALLRHLAGGR----VEVDSAGTEP---GGPVDPRAVAVLAERGIDLSGHRSRQLDEEDlpE 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516233887  79 FDYIIAMDQSNVENIKAINPsikGQLFKLLEFsnmkesDVPDPYYTN--NFEGVYKMVQSSCDNLIDYI 145
Cdd:COG0394   76 FDLVITMCDSAAEELCPLFP---GAAKLLLHW------DVPDPYYGGleAFREVRDEIERRIEALLAKL 135
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
4-141 1.17e-40

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 133.27  E-value: 1.17e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233887    4 VAFVCLGNICRSPMAEAIMRQRLQDRGI-TGVKVHSRGTGKWnLGEPPHEGTQKILNTHGIPFDGMISELF--EPTDDFD 80
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGLgDKVEVDSAGTGAW-PGNPADPRAVEVLKEHGIDLSGHYARQLstEDFASFD 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516233887   81 YIIAMDQSNVENIKAINPSI-KGQLFKLLEFSNMKesDVPDPYYTN--NFEGVYKMVQSSCDNL 141
Cdd:pfam01451  80 LILAMDSEHKRDLCPLAPERyRAKVMLLGEYGEQL--DIPDPYYGSidAFEEVRDLIERRCRQL 141
LMWPc smart00226
Low molecular weight phosphatase family;
4-142 4.59e-33

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 113.72  E-value: 4.59e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233887     4 VAFVCLGNICRSPMAEAIMRQRLQDRgitgVKVHSRGTGKWnLGEPPHEGTQKILNTHGIPFDGMISELFEPT-DDFDYI 82
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYVGDR----VKIDSAGTGAW-VGGGADPRAVKVLKEHGIDLSHHASQLTSSDfKNADLV 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516233887    83 IAMDQSNVENIKAINPSIKGQLFKLLEFsnmkeSDVPDPYY--TNNFEGVYKMVQSSCDNLI 142
Cdd:smart00226  76 LAMDGSHLRNICRLKPPSRAKVELFGHY-----VDVDDPYYggIDGFERVYDELENALQEFL 132
LMWP cd00115
Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group ...
 4-143 4.20e-28

Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group of small soluble enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). This family includes protein tyrosine phosphatases, arginine phosphatases and arsenate reductases.


Pssm-ID: 319970  Cd Length: 137  Bit Score: 101.03  E-value: 4.20e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233887   4 VAFVCLGNICRSPMAEAIMRQRLQDRgitgVKVHSRGTGKWNlGEPPHEGTQKILNTHGIPF----DGMISELFeptDDF 79
Cdd:cd00115    2 ILFICTGNICRSPMAEAIFKQLLGDE----WKVDSAGTGAHH-GEGADPRAVRVLKEVGIDIshrsDQIKSEHL---DNY 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516233887  80 DYIIAMDQSNVENIKAINPSIKGqlFKLLEFSNMKESDVPDPYYTN--NFEGVYKMVQSSCDNLID 143
Cdd:cd00115   74 DLVLVMDGSNLDKIPRIFPEARG--KTWLPHVKLEHGEIDDPYRGDieDFRRVRDELENASKRFAE 137
LMWPAP cd16344
low molecular weight protein arginine phosphatase; Low molecular weight protein arginine ...
 6-122 1.01e-27

low molecular weight protein arginine phosphatase; Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.


Pssm-ID: 319972  Cd Length: 142  Bit Score: 100.20  E-value: 1.01e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233887   6 FVCLGNICRSPMAEAIMRQRLQDRGITgvkVHSRGTGKWNlGEPPHEGTQKILNTHGIPFDGMISELF--EPTDDFDYII 83
Cdd:cd16344    5 FVCTGNTCRSPMAEAILKKLLEELDVE---VKSAGIFAVD-GSPASPNAVEVLKEKGIDLSGHRSQQLteELLEWADLIL 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 516233887  84 AMDQSNVENIKAINPSIKGQLFKLLEFSNMKESDVPDPY 122
Cdd:cd16344   81 TMTESHKQALLSLYPEAADKVFTLKEYVGGEDGDISDPF 119
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 7-135 4.14e-19

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 78.14  E-value: 4.14e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233887   7 VCLGNICRSPMAEAIMRQRLqdrgiTGVKVHSRGTGKWnLGEPPHEGTQKILNTHGIPFDGMISE--LFEPTDDFDYIIA 84
Cdd:PRK11391   8 VCTGNICRSPIGERLLRKRL-----PGVKVKSAGVHGL-VKHPADATAADVAANHGVSLEGHAGRklTAEMARNYDLILA 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 516233887  85 MDQSNVENIKAINPSIKGQlfKLLEFSNMKESDVPDPYYTNN--FEGVYKMVQ 135
Cdd:PRK11391  82 MESEHIAQVTAIAPEVRGK--TMLFGQWLEQKEIPDPYRKSQdaFEHVYGMLE 132
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
7-137 2.32e-13

low molecular weight protein-tyrosine-phosphatase Wzb;


Pssm-ID: 182256  Cd Length: 147  Bit Score: 63.39  E-value: 2.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233887   7 VCLGNICRSPMAEaimrqRLQDRGITGVKVHSRGTGKWnLGEPPHEGTQKILNTHGIPFDGMISELFEP--TDDFDYIIA 84
Cdd:PRK10126   8 VCVGNICRSPTAE-----RLLQRYHPELKVESAGLGAL-VGKGADPTAISVAAEHQLSLEGHCARQISRrlCRNYDLILT 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 516233887  85 MDQSNVENIKAINPSIKGQLFKLLEFSNmkESDVPDPYYTNN--FEGVYKMVQSS 137
Cdd:PRK10126  82 MEKRHIERLCEMAPEMRGKVMLFGHWDN--ECEIPDPYRKSReaFEAVYTLLERS 134
LMWP_ArsC cd16345
Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the ...
 4-85 2.74e-11

Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).


Pssm-ID: 319973  Cd Length: 132  Bit Score: 57.46  E-value: 2.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233887   4 VAFVCLGNICRSPMAEAIMRQRLQDRgitgVKVHSRGTgkwnlgEP--PHEGTQKILNTHGIPFDGMISELFE--PTDDF 79
Cdd:cd16345    2 VLFLCTGNSARSQMAEALLRHLGGDR----FEAYSAGS------EPagVNPLAIEVMKEIGIDISGQRSKSLDefLGQEF 71


                 ....*.
gi 516233887  80 DYIIAM 85
Cdd:cd16345   72 DYVITV 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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