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Conserved domains on  [gi|516456081|ref|WP_017844921|]
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MULTISPECIES: phosphoribosylaminoimidazolesuccinocarboxamide synthase [Pseudomonas]

Protein Classification

phosphoribosylaminoimidazolesuccinocarboxamide synthase( domain architecture ID 10013199)

phosphoribosylaminoimidazolesuccinocarboxamide synthase catalyzes the conversion of 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) in the de novo biosynthesis of purine nucleotides

EC:  6.3.2.6
Gene Ontology:  GO:0005524|GO:0004639

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-237 2.35e-138

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


:

Pssm-ID: 181800  Cd Length: 238  Bit Score: 387.54  E-value: 2.35e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   1 MEKREELYRGKAKSVYKTDDANRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLSDNECL 80
Cdd:PRK09362   1 MEKKELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081  81 VKKLDMIPVECVVRNYAAGSLVKRLGVEEGLKLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSLKVND 160
Cdd:PRK09362  81 VKKVEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKIND 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516456081 161 VLSKLFDDAGLLLVDFKLEFGVFHDGSIVLGDEFSPDGCRLWDKDTKKKMDKDRFRQGLGDVIEAYEEVAKRLGVPL 237
Cdd:PRK09362 161 VLKGLFAGAGIRLVDFKLEFGRDKDGEIVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGELL 237
 
Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-237 2.35e-138

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 387.54  E-value: 2.35e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   1 MEKREELYRGKAKSVYKTDDANRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLSDNECL 80
Cdd:PRK09362   1 MEKKELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081  81 VKKLDMIPVECVVRNYAAGSLVKRLGVEEGLKLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSLKVND 160
Cdd:PRK09362  81 VKKVEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKIND 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516456081 161 VLSKLFDDAGLLLVDFKLEFGVFHDGSIVLGDEFSPDGCRLWDKDTKKKMDKDRFRQGLGDVIEAYEEVAKRLGVPL 237
Cdd:PRK09362 161 VLKGLFAGAGIRLVDFKLEFGRDKDGEIVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGELL 237
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 7-234 7.02e-122

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 345.59  E-value: 7.02e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   7 LYRGKAKSVYKTDDANRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLSDNECLVKKLDM 86
Cdd:cd01415    2 LYEGKAKIVYATDDPDVLIVEFKDDATAFNGKKKDTIEGKGVLNNEISALIFKYLEENGIKTHFIEKLSDREQLVKKVEI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081  87 IPVECVVRNYAAGSLVKRLGVEEGLKLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSLKVNDVLSKLF 166
Cdd:cd01415   82 IPLEVVVRNIAAGSLVKRLGIEEGTVLDPPIVEFYYKNDELGDPLINEDHILALGLATEEELKEIKELALKINEVLSEFF 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516456081 167 DDAGLLLVDFKLEFGVFHDGSIVLGDEFSPDGCRLWDKDTKKKMDKDRFRQGLGDVIEAYEEVAKRLG 234
Cdd:cd01415  162 AEIGIILVDFKLEFGRDKDGEIVLADEISPDTCRLWDKETGEKLDKDRFRRDLGDVIEAYEEVLKRLG 229
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 1-234 2.09e-110

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 317.02  E-value: 2.09e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   1 MEKREELYRGKAKSVYKTDDaNRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLSDNECL 80
Cdd:COG0152    1 MPKLELLYEGKVKDVYATDD-DTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIGIPTHFIETLSGREML 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081  81 VKKLDMIPVECVVRNYAAGSLVKR--------LGVEEGLKLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMK 152
Cdd:COG0152   80 VKKLEMIPVEVVVRNYAAGSLWKRyqagialpLGLEEGTKLPEPIFEPSTKADEGHDPNISEEHIVALGLATEEEAEELR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081 153 ELSLKVNDVLSKLFDDAGLLLVDFKLEFGVFHDGSIVLGDEFSPDGCRLWDKDTKKKMDKDRFRQGLGD-VIEAYEEVAK 231
Cdd:COG0152  160 ELALKINERLSELAAERGIILVDTKLEFGRDADGEIVLADEITPDSSRLWDADTYESLDKDRFRDWLGGnTSEAYIEVLE 239


                 ...
gi 516456081 232 RLG 234
Cdd:COG0152  240 RLT 242
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 7-228 8.74e-109

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 312.37  E-value: 8.74e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081    7 LYRGKAKSVYKTDDANRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLSDNECLVKKLDM 86
Cdd:pfam01259   2 LYEGKVKDVYETDDPDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAGIPTHFIKSLSGREMLVKKVKI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   87 IPVECVVRNYAAGSLVKRL-GVEEGLKLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSLKVNDVLSKL 165
Cdd:pfam01259  82 IPLEVVVRNYAAGSLGKRLpGLKEGTKLPEPIFEPSTKADALGDPNINEEHIVALGLATEEEAEEIRELALKINEILKEY 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516456081  166 FDDAGLLLVDFKLEFGVFHDGSIVLGDEFSPDGCRLWDKDTKKKMDKD----RFRQGLGDVIEAYEE 228
Cdd:pfam01259 162 AAERGIILVDTKLEFGLDSDGEIVLADEITPDSSRFWDADTYEKSQESldkdRFRDDLGDVEEAYQE 228
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 1-231 3.27e-101

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 293.53  E-value: 3.27e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081    1 MEKREELYRGKAKSVYKTDDANRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLSDNECL 80
Cdd:TIGR00081   3 IKKRQKLYSGKAKDIYETDDPDLLRFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEAGIPTHYIDLIEDREML 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   81 VKKLDMIPVECVVRNYAAGSLVKRLGVEEGLKLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSLKVND 160
Cdd:TIGR00081  83 VKKLDIIPLEVIVRNIAAGSLLKRLGIPEGLELEQPLVEFIFKPDEVGDPMLNESYAEALGLATEEELERIKELALKVNE 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516456081  161 VLSKLFDDAGLLLVDFKLEFGVFHDGSIVLGDEFSPDGCRLWDKDTKKKMDKD----RFRQGLGDVIEAYEEVAK 231
Cdd:TIGR00081 163 VLKKYFDEKGIILVDFKLEFGLDEEGNLILADEVSPDTCRLWDKETYEVGAPKldkdIFRRTLGKLIEAYETVAR 237
 
Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-237 2.35e-138

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 387.54  E-value: 2.35e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   1 MEKREELYRGKAKSVYKTDDANRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLSDNECL 80
Cdd:PRK09362   1 MEKKELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081  81 VKKLDMIPVECVVRNYAAGSLVKRLGVEEGLKLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSLKVND 160
Cdd:PRK09362  81 VKKVEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKIND 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516456081 161 VLSKLFDDAGLLLVDFKLEFGVFHDGSIVLGDEFSPDGCRLWDKDTKKKMDKDRFRQGLGDVIEAYEEVAKRLGVPL 237
Cdd:PRK09362 161 VLKGLFAGAGIRLVDFKLEFGRDKDGEIVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGELL 237
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 7-234 7.02e-122

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 345.59  E-value: 7.02e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   7 LYRGKAKSVYKTDDANRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLSDNECLVKKLDM 86
Cdd:cd01415    2 LYEGKAKIVYATDDPDVLIVEFKDDATAFNGKKKDTIEGKGVLNNEISALIFKYLEENGIKTHFIEKLSDREQLVKKVEI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081  87 IPVECVVRNYAAGSLVKRLGVEEGLKLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSLKVNDVLSKLF 166
Cdd:cd01415   82 IPLEVVVRNIAAGSLVKRLGIEEGTVLDPPIVEFYYKNDELGDPLINEDHILALGLATEEELKEIKELALKINEVLSEFF 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516456081 167 DDAGLLLVDFKLEFGVFHDGSIVLGDEFSPDGCRLWDKDTKKKMDKDRFRQGLGDVIEAYEEVAKRLG 234
Cdd:cd01415  162 AEIGIILVDFKLEFGRDKDGEIVLADEISPDTCRLWDKETGEKLDKDRFRRDLGDVIEAYEEVLKRLG 229
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 1-234 2.09e-110

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 317.02  E-value: 2.09e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   1 MEKREELYRGKAKSVYKTDDaNRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLSDNECL 80
Cdd:COG0152    1 MPKLELLYEGKVKDVYATDD-DTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIGIPTHFIETLSGREML 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081  81 VKKLDMIPVECVVRNYAAGSLVKR--------LGVEEGLKLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMK 152
Cdd:COG0152   80 VKKLEMIPVEVVVRNYAAGSLWKRyqagialpLGLEEGTKLPEPIFEPSTKADEGHDPNISEEHIVALGLATEEEAEELR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081 153 ELSLKVNDVLSKLFDDAGLLLVDFKLEFGVFHDGSIVLGDEFSPDGCRLWDKDTKKKMDKDRFRQGLGD-VIEAYEEVAK 231
Cdd:COG0152  160 ELALKINERLSELAAERGIILVDTKLEFGRDADGEIVLADEITPDSSRLWDADTYESLDKDRFRDWLGGnTSEAYIEVLE 239


                 ...
gi 516456081 232 RLG 234
Cdd:COG0152  240 RLT 242
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 7-228 8.74e-109

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 312.37  E-value: 8.74e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081    7 LYRGKAKSVYKTDDANRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLSDNECLVKKLDM 86
Cdd:pfam01259   2 LYEGKVKDVYETDDPDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAGIPTHFIKSLSGREMLVKKVKI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   87 IPVECVVRNYAAGSLVKRL-GVEEGLKLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSLKVNDVLSKL 165
Cdd:pfam01259  82 IPLEVVVRNYAAGSLGKRLpGLKEGTKLPEPIFEPSTKADALGDPNINEEHIVALGLATEEEAEEIRELALKINEILKEY 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516456081  166 FDDAGLLLVDFKLEFGVFHDGSIVLGDEFSPDGCRLWDKDTKKKMDKD----RFRQGLGDVIEAYEE 228
Cdd:pfam01259 162 AAERGIILVDTKLEFGLDSDGEIVLADEITPDSSRFWDADTYEKSQESldkdRFRDDLGDVEEAYQE 228
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 1-231 3.27e-101

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 293.53  E-value: 3.27e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081    1 MEKREELYRGKAKSVYKTDDANRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLSDNECL 80
Cdd:TIGR00081   3 IKKRQKLYSGKAKDIYETDDPDLLRFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEAGIPTHYIDLIEDREML 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   81 VKKLDMIPVECVVRNYAAGSLVKRLGVEEGLKLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSLKVND 160
Cdd:TIGR00081  83 VKKLDIIPLEVIVRNIAAGSLLKRLGIPEGLELEQPLVEFIFKPDEVGDPMLNESYAEALGLATEEELERIKELALKVNE 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516456081  161 VLSKLFDDAGLLLVDFKLEFGVFHDGSIVLGDEFSPDGCRLWDKDTKKKMDKD----RFRQGLGDVIEAYEEVAK 231
Cdd:TIGR00081 163 VLKKYFDEKGIILVDFKLEFGLDEEGNLILADEVSPDTCRLWDKETYEVGAPKldkdIFRRTLGKLIEAYETVAR 237
SAICAR_synt cd00476
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase ...
 6-234 4.43e-85

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase (the PurC gene product) catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133468  Cd Length: 230  Bit Score: 252.38  E-value: 4.43e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   6 ELYRGKAKSVYKTDDaNRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLSDNECLVKKLD 85
Cdd:cd00476    1 TLYRGKTKIVYETKD-GVLLLEFKDDISAGDGARRNFLDEKGDITAKLTLFIFKYLSEAGIPTHFVERLGPRTLLVDKLK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081  86 MIPVECVVRNYAAGSLVKRL-GVEEGLKLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSLKVNDVLSK 164
Cdd:cd00476   80 *IPLEVVVRNRATGSFVKRYgGFKEGREFPPPLVEFFYKDDAEHDPIVSEDQLERLGFIGKVDVER*KELAVKINTVLKK 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516456081 165 LFDDAGLLLVDFKLEFGVFHDGSIVLGDEFSPDGCRLW-DKDTKKKMDKDRFRQGLGDVIEAYEEVAKRLG 234
Cdd:cd00476  160 LFSPAGLELWDFKLEFGLDEEGEIVLGDEISPDSSRLWrKGGEPYDKDLFRRRASLGQIIEKYEEVAELVR 230
SAICAR_synt_Ade5 cd01416
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 5-202 5.63e-41

Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133471  Cd Length: 252  Bit Score: 140.51  E-value: 5.63e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   5 EELYRGKAKSVYKTDDANRLILLFRNDT-SAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLSDNECLVKK 83
Cdd:cd01416    5 KKLIEGKTKIVYELPDQPGLVLIQSKDRiTAGDGARKDEIEGKAAISNKTTSNVFELLQEAGIKTHFVKQCSPTAFIARK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081  84 LDMIPVECVVRNYAAGSLVKR-LGVEEGLKLNPYTFELFLKDDAKGDPFINESHVVAFGWG------TAEQLARMKELSL 156
Cdd:cd01416   85 CEMIPIEWVCRRIATGSFLKRnPGVKEGYRFSPPKLEFFYKDDANHDPQWSEEQLLEAKLNcgglkiGKKEVDIMTKSTI 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 516456081 157 KVNDVLSKLFDDAGLLLVDFKLEFGVFHD-GSIVLGDEFSPDGCRLW 202
Cdd:cd01416  165 AIFEILEKAWATQDCTLVDMKIEFGVDVTtGEILLADVIDNDSWRLW 211
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 7-202 3.18e-34

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 123.81  E-value: 3.18e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   7 LYRGKAKSVYKTDDaNRLILLFRNDTSAFDgkRIEQLD--RKGMVNNKFNAFIMQKLEAaGIPTQF-------------D 71
Cdd:cd01414    2 IYSGKVRDVYDLGD-GRLLFVATDRISAFD--VILPPDipGKGEVLTQISAFWFELTED-IIPNHListdvedlpeikeP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081  72 KLLSDNECLVKKLDMIPVECVVRNYAAGSLVKR---------LGVEEGLKLN-----PYtFELFLKDDAKGDPFINESHV 137
Cdd:cd01414   78 EDPDGRSMVVKKAKPIPIECIVRGYLTGSGWKEyqkggtvcgIKLPEGLREAqklpePI-FTPSTKAEEGHDENISFEEA 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516456081 138 VAfgWGTAEQLARMKELSLKVNDVLSKLFDDAGLLLVDFKLEFGVFHDGSIVLGDEF-SPDGCRLW 202
Cdd:cd01414  157 VE--IIGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLDENGEIILIDEVlTPDSSRFW 220
PRK13961 PRK13961
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 7-202 9.30e-19

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237571  Cd Length: 296  Bit Score: 82.94  E-value: 9.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   7 LYRGKAKSVYKTDDaNRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLE------------AAGIPTQFDKLL 74
Cdd:PRK13961  15 LGRGKVRDIYAVDD-DRLLMVATDRISAFDVILPEPIPDKGRVLTQMSNFWFDKLAhivpnhltgidvDDVVPADEADQV 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081  75 SDNECLVKKLDMIPVECVVRNYAAGSLVK-----------RL--GVEEGLKLNPYTFELFLKDDAKG-DPFINESHVVA- 139
Cdd:PRK13961  94 LGRAVVVKKLKPLPVECVVRGYLTGSGWKdyqatgtvcgiKLpaGLVEASKLPEPIFTPATKAELGDhDENISFEEVVEl 173

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516456081 140 FGWGTAEQLarmKELSLKVNDVLSKLFDDAGLLLVDFKLEFGVFHDGSIVLGDE-FSPDGCRLW 202
Cdd:PRK13961 174 VGAELAAQL---RDATLAIYKEAADYAATRGIIIADTKFEFGLDEDGTLTLMDEvLTPDSSRFW 234
PRK12607 PRK12607
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 6-202 6.99e-18

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 183621 [Multi-domain]  Cd Length: 313  Bit Score: 80.70  E-value: 6.99e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   6 ELYRGKAKSVYKTDDaNRLILLFRNDTSAFDgkRI-EQLDRKGMVNNKFNAFIMQKLEAAgIPTQFDKLLSDNECLVKKL 84
Cdd:PRK12607  17 NVYRGKVRDNYDLPD-GRRVMVATDRISAFD--RVlPAIPYKGQVLNQTAAFWFEATKDI-CPNHVLAVPDPNVVVGKRC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081  85 DMIPVECVVRNYAAGSLV------KR--LGVE--EGLKLN---------PYTFElflkDDAKGDPFINESHVVAFGWGTA 145
Cdd:PRK12607  93 EPFPVEMVVRGYLAGSTWrlykagKRemYGVTlpDGLRENqklpepiitPTTKA----EEGGHDEPISPEEILAQGLLTP 168

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 516456081 146 EQLARMKELSLKVNDVLSKLFDDAGLLLVDFKLEFGVFHDGSIVLGDEF-SPDGCRLW 202
Cdd:PRK12607 169 EDWDELSKYALALFARGQEMAAERGLILVDTKYEFGKDADGRIVLIDEIhTPDSSRYW 226
PRK13959 PRK13959
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 9-201 1.05e-17

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237570  Cd Length: 341  Bit Score: 80.49  E-value: 1.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   9 RGKAKSVY-----KTDDANRLILLFRNDTSAFDGKRI-EQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLSD------ 76
Cdd:PRK13959   1 MGSVKDFYvdeepTETDLGRGRFVFSDRYSVFDWGIMpDEIPDKGASLCTMGAYNFELLEEEGIKTHYIGVVEDgevvrl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081  77 -------NECLVKKLD------------------------MIPVECVVRNY--AAGSLVKRLG----------------V 107
Cdd:PRK13959  81 aeaseppNEMAVKLTQvpdlpfeggsydydayheaagenyLIPLEVIFRNYvpVGSSLRDRIKegkikpedlgldadewP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081 108 EEGLKLNPYTFELFLKDDaKGDPFINESHVVAFGWGTAEQLARMKELSLKVNDVLSKLFDDAGLLLVDFKLEFGVFHDGS 187
Cdd:PRK13959 161 EEGVKLPEPIVEFSTKYE-EQDRYLSRKEADEIAGLSRAEIEELEELALKVDEIITEEAEKRGLIHEDGKIEFALYEERE 239

                        250
                 ....*....|....*
gi 516456081 188 IVLGDEF-SPDGCRL 201
Cdd:PRK13959 240 IRVVDVVgTFDENRF 254
PLN02544 PLN02544
phosphoribosylaminoimidazole-succinocarboxamide synthase
 8-219 8.71e-14

phosphoribosylaminoimidazole-succinocarboxamide synthase


Pssm-ID: 178159 [Multi-domain]  Cd Length: 370  Bit Score: 69.47  E-value: 8.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081   8 YRGKAKSVYKTDDanRLILLFRNDTSAFDgKRIEQLDRKGMVNNKFNAFIMQKLEAAgIPTQFDKLLSDNECLVKKLDMI 87
Cdd:PLN02544  79 RRGKVRDIYDLGD--YLVLVTTDRQSAFD-RVLASIPFKGQVLNQTSAWWFNNTKHI-TPNALVSSPDPNVTIAKKCSVF 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516456081  88 PVECVVRNYAAGSLVKRL------GVE--------EGLKLN---------PYTFElflkddAKGDPFINESHVVAFGWGT 144
Cdd:PLN02544 155 PVEFVVRGYMTGSTSTSLwtvynkGVRnycgndlpDGMVKNqklpaniltPTTKA------ADHDVPISPEEIVEEGLMT 228

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516456081 145 AEQLARMKELSLKVNDVLSKLFDDAGLLLVDFKLEFGVFHDGSIVLGDEF-SPDGCRLWdkdtKKKMDKDRFRQGL 219
Cdd:PLN02544 229 QEDFDEVSSKALALFAFGQEVAAEHGLILVDTKYEFGKDADGTILLIDEVhTPDSSRYW----LADSYEERHAAGL 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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