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Conserved domains on  [gi|518299754|ref|WP_019469962|]
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MULTISPECIES: nickel transporter permease [Staphylococcus]

Protein Classification

ABC transporter permease( domain architecture ID 11439449)

ABC transporter permease is the transmembrane (TM) subunit in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which generally binds a type 2 PBP; similar to the permease subunit of ABC-type dipeptide/oligopeptide/nickel transport systems

Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 4-264 1.26e-91

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


:

Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 271.99  E-value: 1.26e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754   4 KNKGSFI-FYVFGIYVLLLIVAQFLISADsALEVHLSHTLELPSSTHWLGTDDYGRDLLARVIVGARYTLIISLITLLIT 82
Cdd:COG1173   14 RNPLAVIgLVILLLLVLLALFAPLLAPYD-PTAQDLAARLQPPSAAHWLGTDQLGRDVLSRLLYGARISLLVGLLAVLIA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  83 VIIGVPLGLLAGYKKGFVDTIIMRVIDIGLSIPEFVLMIAMASFFKPSIWNLVIAITIIKWMTYTRLTRSIVSSEISKPY 162
Cdd:COG1173   93 LVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGPGLLNVILALGLTGWPGYARLVRAQVLSLREREY 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754 163 IQMAKLFNVPTHRIILKHFFPQVMPSVIVLMTVDFGKIILYISSLSFLGLGAQPPSPEWGAMLNAGRDYISSYPLLIIVP 242
Cdd:COG1173  173 VEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLGVQPPTPSWGTMLSEGRNYLLTAPWLALFP 252

                        250       260
                 ....*....|....*....|..
gi 518299754 243 AFLITVTILLFNLTGDALRDRL 264
Cdd:COG1173  253 GLAIVLTVLAFNLLGDGLRDAL 274
 
Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 4-264 1.26e-91

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 271.99  E-value: 1.26e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754   4 KNKGSFI-FYVFGIYVLLLIVAQFLISADsALEVHLSHTLELPSSTHWLGTDDYGRDLLARVIVGARYTLIISLITLLIT 82
Cdd:COG1173   14 RNPLAVIgLVILLLLVLLALFAPLLAPYD-PTAQDLAARLQPPSAAHWLGTDQLGRDVLSRLLYGARISLLVGLLAVLIA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  83 VIIGVPLGLLAGYKKGFVDTIIMRVIDIGLSIPEFVLMIAMASFFKPSIWNLVIAITIIKWMTYTRLTRSIVSSEISKPY 162
Cdd:COG1173   93 LVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGPGLLNVILALGLTGWPGYARLVRAQVLSLREREY 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754 163 IQMAKLFNVPTHRIILKHFFPQVMPSVIVLMTVDFGKIILYISSLSFLGLGAQPPSPEWGAMLNAGRDYISSYPLLIIVP 242
Cdd:COG1173  173 VEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLGVQPPTPSWGTMLSEGRNYLLTAPWLALFP 252

                        250       260
                 ....*....|....*....|..
gi 518299754 243 AFLITVTILLFNLTGDALRDRL 264
Cdd:COG1173  253 GLAIVLTVLAFNLLGDGLRDAL 274
nickel_nikC TIGR02790
nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of ...
 7-264 1.23e-73

nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of nickel ABC transporter permeases. Operons that contain this protein also contain a homologous permease subunit NikB. Nickel is used in cells as part of urease or certain hydrogenases or superoxide dismutases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131837 [Multi-domain]  Cd Length: 258  Bit Score: 225.73  E-value: 1.23e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754    7 GSFIFYVFGIYVLLLIVAQFLISADSaLEVHLSHTLELPSSTHWLGTDDYGRDLLARVIVGARYTLIISLITLLITVIIG 86
Cdd:TIGR02790   1 VVSALLIIAVLFLLAIFAPWIAPHDP-LAQNLPMRLLGPSMEYWLGTDHLGRCIFSRLIFGARVSLGSALLVLGLVLTIG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754   87 VPLGLLAGYKKGFVDTIIMRVIDIGLSIPEFVLMIAMASFFKPSIWNLVIAITIIKWMTYTRLTRSIVSSEISKPYIQMA 166
Cdd:TIGR02790  80 LLIGGLAGYIGGRVDEAIMRVCDVFLSFPTIILSLAIVGILGPGLENVIIAIVLVHWAWYARMVRGMVVSLKQREFVLAA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  167 KLFNVPTHRIILKHFFPQVMPSVIVLMTVDFGKIILYISSLSFLGLGAQPPSPEWGAMLNAGRDYISSYPLLIIVPAFLI 246
Cdd:TIGR02790 160 RTSGASHWQIIRRHILPNILSPIIVLATLDIGHVILHIAGLSFLGLGIQPPTPEWGAMLSEAKQYIWTQPLLMIYPGLAI 239

                         250
                  ....*....|....*...
gi 518299754  247 TVTILLFNLTGDALRDRL 264
Cdd:TIGR02790 240 LISVMAFNLLGDALRDHL 257
nikC PRK10417
nickel transporter permease NikC; Provisional
 13-264 8.90e-62

nickel transporter permease NikC; Provisional


Pssm-ID: 236687 [Multi-domain]  Cd Length: 272  Bit Score: 196.04  E-value: 8.90e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  13 VFGIYVLLLIVAQFLISADsALEVHLSHTLELPSSTHWLGTDDYGRDLLARVIVGARYTLIISLITLLITVIIGVPLGLL 92
Cdd:PRK10417  12 IIALLALIALTSQWWLPYD-PQAIDLPSRLLSPDAQHWLGTDHLGRDIFSRLMAGTRVSLGSVMACLLLVLALGLVIGGS 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  93 AGYKKGFVDTIIMRVIDIGLSIPEFVLMIAMASFFKPSIWNLVIAITIIKWMTYTRLTRSIVSSEISKPYIQMAKLFNVP 172
Cdd:PRK10417  91 AGLLGGRVDQATMRVADMFMTFPTSILAFFMVGVLGTGLTNVIIAIALSHWAWYARMVRSLVISLRQREFVLAARLSGAG 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754 173 THRIILKHFFPQVMPSVIVLMTVDFGKIILYISSLSFLGLGAQPPSPEWGAMLNAGRDYISSYPLLIIVPAFLITVTILL 252
Cdd:PRK10417 171 HVRVFIDHLLPAVIPQLLVLATLDIGHMMLHVAGLSFLGLGVTAPTAEWGVMINDARQYIWTQPLLMFWPGLALFISVMA 250

                        250
                 ....*....|..
gi 518299754 253 FNLTGDALRDRL 264
Cdd:PRK10417 251 FNLLGDALRDHL 262
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 86-269 5.24e-17

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 76.57  E-value: 5.24e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754   86 GVPLGLLAG-YKKGFVDTIIMRVIDIGLSIPEFVLMIAMASFFKPSIWNL----VIAITIIKWMTYTRLTRSIVSSEISK 160
Cdd:pfam00528   1 GIPLGIIAAlRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHgilpAIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  161 PYIQMAKLFNVPTHRIILKHFFPQVMPSVIVLMTVDFGKIILYISSLSFL----GLGAQPPSPEWGAMLNagrdyissyp 236
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswpGLGLLLIEAILGYDYP---------- 150

                         170       180       190
                  ....*....|....*....|....*....|...
gi 518299754  237 lLIIVPAFLITVTILLFNLTGDALRDRLLKRKR 269
Cdd:pfam00528 151 -EIQGPVLAAALILLLLNLLVDILQRLLDPRVR 182
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 83-250 6.14e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 76.55  E-value: 6.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  83 VIIGVPLGLLAGYKKGFVDTIIMRVIDIGLSIPEFVLMIAMASFFK--------PSIWNLVIAITIIKWMTYTRLTRSIV 154
Cdd:cd06261   16 LVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGvllgwgilPGLGLPALILALLLIAPFARLIRRAA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754 155 SSEISKPYIQMAKLFNVPTHRIILKHFFPQVMPSVIVLMTVDFGKIILYISSLSFLGLGAqPPSPEWGAMLNAGRDYISS 234
Cdd:cd06261   96 LESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE-APGPGTGLLLIFAILFPGD 174

                        170
                 ....*....|....*.
gi 518299754 235 YPLLIIVPAFLITVTI 250
Cdd:cd06261  175 LGVAAAVALILLLLSL 190
 
Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 4-264 1.26e-91

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 271.99  E-value: 1.26e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754   4 KNKGSFI-FYVFGIYVLLLIVAQFLISADsALEVHLSHTLELPSSTHWLGTDDYGRDLLARVIVGARYTLIISLITLLIT 82
Cdd:COG1173   14 RNPLAVIgLVILLLLVLLALFAPLLAPYD-PTAQDLAARLQPPSAAHWLGTDQLGRDVLSRLLYGARISLLVGLLAVLIA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  83 VIIGVPLGLLAGYKKGFVDTIIMRVIDIGLSIPEFVLMIAMASFFKPSIWNLVIAITIIKWMTYTRLTRSIVSSEISKPY 162
Cdd:COG1173   93 LVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGPGLLNVILALGLTGWPGYARLVRAQVLSLREREY 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754 163 IQMAKLFNVPTHRIILKHFFPQVMPSVIVLMTVDFGKIILYISSLSFLGLGAQPPSPEWGAMLNAGRDYISSYPLLIIVP 242
Cdd:COG1173  173 VEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLGVQPPTPSWGTMLSEGRNYLLTAPWLALFP 252

                        250       260
                 ....*....|....*....|..
gi 518299754 243 AFLITVTILLFNLTGDALRDRL 264
Cdd:COG1173  253 GLAIVLTVLAFNLLGDGLRDAL 274
nickel_nikC TIGR02790
nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of ...
 7-264 1.23e-73

nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of nickel ABC transporter permeases. Operons that contain this protein also contain a homologous permease subunit NikB. Nickel is used in cells as part of urease or certain hydrogenases or superoxide dismutases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131837 [Multi-domain]  Cd Length: 258  Bit Score: 225.73  E-value: 1.23e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754    7 GSFIFYVFGIYVLLLIVAQFLISADSaLEVHLSHTLELPSSTHWLGTDDYGRDLLARVIVGARYTLIISLITLLITVIIG 86
Cdd:TIGR02790   1 VVSALLIIAVLFLLAIFAPWIAPHDP-LAQNLPMRLLGPSMEYWLGTDHLGRCIFSRLIFGARVSLGSALLVLGLVLTIG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754   87 VPLGLLAGYKKGFVDTIIMRVIDIGLSIPEFVLMIAMASFFKPSIWNLVIAITIIKWMTYTRLTRSIVSSEISKPYIQMA 166
Cdd:TIGR02790  80 LLIGGLAGYIGGRVDEAIMRVCDVFLSFPTIILSLAIVGILGPGLENVIIAIVLVHWAWYARMVRGMVVSLKQREFVLAA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  167 KLFNVPTHRIILKHFFPQVMPSVIVLMTVDFGKIILYISSLSFLGLGAQPPSPEWGAMLNAGRDYISSYPLLIIVPAFLI 246
Cdd:TIGR02790 160 RTSGASHWQIIRRHILPNILSPIIVLATLDIGHVILHIAGLSFLGLGIQPPTPEWGAMLSEAKQYIWTQPLLMIYPGLAI 239

                         250
                  ....*....|....*...
gi 518299754  247 TVTILLFNLTGDALRDRL 264
Cdd:TIGR02790 240 LISVMAFNLLGDALRDHL 257
nikC PRK10417
nickel transporter permease NikC; Provisional
 13-264 8.90e-62

nickel transporter permease NikC; Provisional


Pssm-ID: 236687 [Multi-domain]  Cd Length: 272  Bit Score: 196.04  E-value: 8.90e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  13 VFGIYVLLLIVAQFLISADsALEVHLSHTLELPSSTHWLGTDDYGRDLLARVIVGARYTLIISLITLLITVIIGVPLGLL 92
Cdd:PRK10417  12 IIALLALIALTSQWWLPYD-PQAIDLPSRLLSPDAQHWLGTDHLGRDIFSRLMAGTRVSLGSVMACLLLVLALGLVIGGS 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  93 AGYKKGFVDTIIMRVIDIGLSIPEFVLMIAMASFFKPSIWNLVIAITIIKWMTYTRLTRSIVSSEISKPYIQMAKLFNVP 172
Cdd:PRK10417  91 AGLLGGRVDQATMRVADMFMTFPTSILAFFMVGVLGTGLTNVIIAIALSHWAWYARMVRSLVISLRQREFVLAARLSGAG 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754 173 THRIILKHFFPQVMPSVIVLMTVDFGKIILYISSLSFLGLGAQPPSPEWGAMLNAGRDYISSYPLLIIVPAFLITVTILL 252
Cdd:PRK10417 171 HVRVFIDHLLPAVIPQLLVLATLDIGHMMLHVAGLSFLGLGVTAPTAEWGVMINDARQYIWTQPLLMFWPGLALFISVMA 250

                        250
                 ....*....|..
gi 518299754 253 FNLTGDALRDRL 264
Cdd:PRK10417 251 FNLLGDALRDHL 262
PRK09881 PRK09881
D,D-dipeptide ABC transporter permease;
16-264 1.86e-57

D,D-dipeptide ABC transporter permease;


Pssm-ID: 182131 [Multi-domain]  Cd Length: 296  Bit Score: 185.79  E-value: 1.86e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  16 IYVLLLIVAQFLISADSALEVHLSHTLELPSSTHWLGTDDYGRDLLARVIVGARYTLIISLITLLITVIIGVPLGLLAGY 95
Cdd:PRK09881  41 VLMLLMMIFSPWLATHDPNAIDLTARLLPPSAAHWFGTDEVGRDLFSRVLVGSQQSILAGLVVVAIAGMIGSLLGCLSGV 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  96 KKGFVDTIIMRVIDIGLSIPEFVLMIAMASFFKPSIWNLVIAITIIKWMTYTRLTRSIVSSEISKPYIQMAKLFNVPTHR 175
Cdd:PRK09881 121 LGGRADAIIMRIMDIMLSIPSLVLTMALAAALGPSLFNAMLAIAIVRIPFYVRLARGQALVVRQYTYVQAAKTFGASRWH 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754 176 IILKHFFPQVMPSVIVLMTVDFGKIILYISSLSFLGLGAQPPSPEWGAMLNAGRDYISSYPLLIIVPAFLITVTILLFNL 255
Cdd:PRK09881 201 LISWHILRNSLPPLIVQASLDIGSAILMAATLGFIGLGAQQPSAEWGAMVANGRNYVLDQWWYCAFPGAAILLTAVGFNL 280


                 ....*....
gi 518299754 256 TGDALRDRL 264
Cdd:PRK09881 281 FGDGIRDLL 289
PRK10913 PRK10913
dipeptide ABC transporter permease DppC;
4-264 3.57e-51

dipeptide ABC transporter permease DppC;


Pssm-ID: 182833 [Multi-domain]  Cd Length: 300  Bit Score: 169.58  E-value: 3.57e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754   4 KNKGSFIFYVFGIYVLLLIVAQFLISADSALEVHLSHTLELP------SSTHWLGTDDYGRDLLARVIVGARYTLIISLI 77
Cdd:PRK10913  28 RNKGAVVGLVYVVIMLFIAIFANWIAPHNPAEQFRDALLAPPvwqeggSWAHILGTDDVGRDVLSRLMYGARLSLLVGCL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  78 TLLITVIIGVPLGLLAGYKKGFVDTIIMRVIDIGLSIPEFVLMIAMASFFKPSIWNLVIAITIIKWMTYTRLTRSIVSSE 157
Cdd:PRK10913 108 VVVLSLVMGVILGLIAGYFGGLVDNIIMRVVDIMLALPSLLLALVLVAIFGPSIVNAALALTFVALPHYVRLTRAAVLVE 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754 158 ISKPYIQMAKLFNVPTHRIILKHFFPQVMPSVIVLMTVDFGKIILYISSLSFLGLGAQPPSPEWGAMLNAGRDYISSYPL 237
Cdd:PRK10913 188 VNRDYVTASRVAGAGAMRQMFINILPNCLAPLIVQASLGFSNAILDMAALGFLGMGAQPPTPEWGTMLSDVLQFAQSAWW 267

                        250       260
                 ....*....|....*....|....*..
gi 518299754 238 LIIVPAFLITVTILLFNLTGDALRDRL 264
Cdd:PRK10913 268 VVTFPGLAILLTVLAFNLMGDGLRDAL 294
PRK15082 PRK15082
glutathione ABC transporter permease GsiD; Provisional
 15-264 1.32e-50

glutathione ABC transporter permease GsiD; Provisional


Pssm-ID: 185040 [Multi-domain]  Cd Length: 301  Bit Score: 167.98  E-value: 1.32e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  15 GIYVLLLIV----AQFLISADSALEVHLSHTLELPSSTHWLGTDDYGRDLLARVIVGARYTLIISLITLLITVIIGVPLG 90
Cdd:PRK15082  42 GLFVLLLIVvaifAPWIAPYDAENYFDYDALNAGPSLQHWFGVDSLGRDIFSRILVGARISLAAGFFSVAIGAAIGTVLG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  91 LLAGYKKGFVDTIIMRVIDIGLSIPEFVLMIAMASFFKPSIWNLVIAITIIKWMTYTRLTRSIVSSEISKPYIQMAKLFN 170
Cdd:PRK15082 122 LLAGYYEGWWDRIIMRICDVLFAFPGILLAIAVVAILGSGMANVIIAVAIFSIPAFARLVRGNTLVLKQQTYIESARSIG 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754 171 VPTHRIILKHFFPQVMPSVIVLMTVDFGKIILYISSLSFLGLGAQPPSPEWGAMLNAGRDYISSYPLLIIVPAFLITVTI 250
Cdd:PRK15082 202 ASDWTILLRHILPGTVSSIVVYFTMRIGTSIITAASLSFLGLGAQPPTPEWGAMLNEARADMVIAPHVALFPSLAIFLTV 281

                        250
                 ....*....|....
gi 518299754 251 LLFNLTGDALRDRL 264
Cdd:PRK15082 282 LAFNLLGDGLRDAL 295
SapC COG4171
ABC-type antimicrobial peptide export system, permease component SapC [Defense mechanisms];
3-267 2.25e-47

ABC-type antimicrobial peptide export system, permease component SapC [Defense mechanisms];


Pssm-ID: 443331 [Multi-domain]  Cd Length: 296  Bit Score: 159.60  E-value: 2.25e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754   3 HKNKGSFI-FYVFGIYVLLLIVAQfLISADSALEVHLSHTLELPS------STHWLGTDDYGRDLLARVIVGARYTLIIS 75
Cdd:COG4171   24 RKNPLAMIgLYGFLFLILLALFGP-LLAPYSPDQQFIGALLLPPSwddngdVSFFLGTDDLGRDILSRLLYGARYTFGSA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  76 LITLLITVIIGVPLGLLAGYKKGFVDTIIMRVIDIGLSIPEFVLMIAMASFFKPSIWNLVIAITIIKWMTYTRLTRSIVS 155
Cdd:COG4171  103 LLVVLAAAIIGGIIGILAGMSRGLKSSILNHLLDTLLSIPSLLLAIIIVALLGPGLENAMLAITLALLPQFIHAIYQAVH 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754 156 SEISKPYIQMAKLFNVPTHRIILKHFFPQVMPSVIVLMTVDFGKIILYISSLSFLGLGAQPPSPEWGAMLNAGRDYISSY 235
Cdd:COG4171  183 QELKKEYVLAARLDGASNWQLLRYSILPNILEVLVTELTRALSIAILDISALGFLGLGAQLPSPEWGAMLGDSLELIYLA 262

                        250       260       270
                 ....*....|....*....|....*....|..
gi 518299754 236 PLLIIVPAFLITVTILLFNLTGDALRDRLLKR 267
Cdd:COG4171  263 PWTVILPGLAIMFSVLIVNLVGDGLRRALNKG 294
PRK15406 PRK15406
oligopeptide ABC transporter permease OppC; Provisional
 46-269 3.36e-41

oligopeptide ABC transporter permease OppC; Provisional


Pssm-ID: 185304 [Multi-domain]  Cd Length: 302  Bit Score: 143.82  E-value: 3.36e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  46 SSTHWLGTDDYGRDLLARVIVGARYTLIISLITLLITVIIGVPLGLLAGYKKGFVDTIIMRVIDIGLSIPEFVLMIAMAS 125
Cdd:PRK15406  79 ESGHYFGTDSSGRDLLVRVAIGGRISLMVGVAAALVAVVVGTLYGSLSGYLGGKVDSVMMRLLEILNSFPFMFFVILLVT 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754 126 FFKPSIWNLVIAITIIKWMTYTRLTRSIVSSEISKPYIQMAKLFNVPTHRIILKHFFPQVMPSVIVLMTVDFGKIILYIS 205
Cdd:PRK15406 159 FFGQNILLIFVAIGMVSWLDMARIVRGQTLSLKRKEFIEAAQVGGVSTRGIVLRHIVPNVLGVVVVYASLLVPSMILFES 238

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518299754 206 SLSFLGLGAQPPSPEWGAMLNAGRDYISSYPLLIIVPAFLITVTILLFNLTGDALRDRLLKRKR 269
Cdd:PRK15406 239 FLSFLGLGTQEPLSSWGALLSDGANSMEVSPWLLLFPAGFLVVTLFCFNFIGDGLRDALDPKDR 302
YejE COG4239
ABC-type microcin C transport system, permease component YejE [Secondary metabolites ...
 45-271 9.32e-38

ABC-type microcin C transport system, permease component YejE [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443381 [Multi-domain]  Cd Length: 342  Bit Score: 135.66  E-value: 9.32e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  45 PSSTHWLGTDDYGRDLLARVIVGARYTLIISLITLLITVIIGVPLGLLAGYKKGFVDTIIMRVIDIGLSIPEFVLMIAMA 124
Cdd:COG4239  117 PSAENWLGTDDQGRDVLARLIYGFRISVLFGLALTVISSVIGVAAGAVQGYFGGRVDLLFQRFIEIWSSMPELYLLIILS 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754 125 SFFKPSIWNLVIAITIIKWMTYTRLTRSIVSSEISKPYIQMAKLFNVPTHRIILKHFFPQVMPSVIVLMTVDFGKIILYI 204
Cdd:COG4239  197 SIFQPSFWLLLGILLLFGWMGLVGVVRAEFLRARNLEYVRAARALGVSDRRIMFRHILPNAMVATLTFLPFILSGAITTL 276

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518299754 205 SSLSFLGLGAQPPSPEWGAMLNAGRDYISSyPLLIIVPAFLITVTILLFNLTGDALRDRLLKRKRDA 271
Cdd:COG4239  277 TSLDFLGFGLPPGSPSLGELLAQGKNNLQA-PWLGLSAFVVLALMLSLLVFIGEAVRDAFDPRKTFR 342
PRK15111 PRK15111
peptide ABC transporter permease SapC;
11-261 2.38e-33

peptide ABC transporter permease SapC;


Pssm-ID: 185066 [Multi-domain]  Cd Length: 296  Bit Score: 122.89  E-value: 2.38e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  11 FYVFGIYVLLLIVAQFLisADSALEVH-LSHTLELPSSTHW------LGTDDYGRDLLARVIVGARYTLIISLITLLITV 83
Cdd:PRK15111  33 LYGCAGLALLCLFGGWL--APYGIDQQfLGYQLLPPSWSRYgevsffLGTDDLGRDVLSRLLSGAAPTVGGAFVVTLAAT 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  84 IIGVPLGLLAGYKKGFVDTIIMRVIDIGLSIPEFVLMIAMASFFKPSIWNLVIAItiikWMT-YTRLTRSI---VSSEIS 159
Cdd:PRK15111 111 LCGLVLGVFAGATHGLRSAVLNHILDTLLSIPSLLLAIIVVAFAGPSLSHAMFAV----WLAlLPRMVRSIysaVHDELE 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754 160 KPYIQMAKLFNVPTHRIILKHFFPQVMPSVIVLMTVDFGKIILYISSLSFLGLGAQPPSPEWGAMLNAGRDYISSYPLLI 239
Cdd:PRK15111 187 KEYVIAARLDGASTLNILWYAVLPNITAGLVTEITRALSMAILDIAALGFLDLGAQLPSPEWGAMLGDSLELIYVAPWTV 266

                        250       260
                 ....*....|....*....|..
gi 518299754 240 IVPAFLITVTILLFNLTGDALR 261
Cdd:PRK15111 267 MLPGAAIMLSVLLVNLLGDGIR 288
PRK15021 PRK15021
microcin C ABC transporter permease; Provisional
 45-262 6.00e-28

microcin C ABC transporter permease; Provisional


Pssm-ID: 184982 [Multi-domain]  Cd Length: 341  Bit Score: 109.69  E-value: 6.00e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  45 PSSTHWLGTDDYGRDLLARVIVGARYTLIISLITLLITVIIGVPLGLLAGYKKGFVDTIIMRVIDIGLSIPEFVLMIAMA 124
Cdd:PRK15021 117 PSRQNWLGTDANGGDVLARILYGTRISVLFGLMLTLCSSVMGVLAGALQGYYGGKVDLWGQRFIEVWSGMPTLFLIILLS 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754 125 SFFKPSIWNLVIAITIIKWMTYTRLTRSIVSSEISKPYIQMAKLFNVPTHRIILKHFFPQVMPSVIVLMTVDFGKIILYI 204
Cdd:PRK15021 197 SVVQPNFWWLLAITVLFGWMSLVGVVRAEFLRTRNFDYIRAAQALGVSDRSIILRHMLPNAMVATLTFLPFILCSSITTL 276

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 518299754 205 SSLSFLGLGAQPPSPEWGAMLNAGRDYISSyPLLIIVPAFLITVTILLFNLTGDALRD 262
Cdd:PRK15021 277 TSLDFLGFGLPLGSPSLGELLLQGKNNLQA-PWLGITAFLSVAILLSLLIFIGEAVRD 333
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 86-269 5.24e-17

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 76.57  E-value: 5.24e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754   86 GVPLGLLAG-YKKGFVDTIIMRVIDIGLSIPEFVLMIAMASFFKPSIWNL----VIAITIIKWMTYTRLTRSIVSSEISK 160
Cdd:pfam00528   1 GIPLGIIAAlRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHgilpAIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  161 PYIQMAKLFNVPTHRIILKHFFPQVMPSVIVLMTVDFGKIILYISSLSFL----GLGAQPPSPEWGAMLNagrdyissyp 236
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswpGLGLLLIEAILGYDYP---------- 150

                         170       180       190
                  ....*....|....*....|....*....|...
gi 518299754  237 lLIIVPAFLITVTILLFNLTGDALRDRLLKRKR 269
Cdd:pfam00528 151 -EIQGPVLAAALILLLLNLLVDILQRLLDPRVR 182
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 83-250 6.14e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 76.55  E-value: 6.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  83 VIIGVPLGLLAGYKKGFVDTIIMRVIDIGLSIPEFVLMIAMASFFK--------PSIWNLVIAITIIKWMTYTRLTRSIV 154
Cdd:cd06261   16 LVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGvllgwgilPGLGLPALILALLLIAPFARLIRRAA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754 155 SSEISKPYIQMAKLFNVPTHRIILKHFFPQVMPSVIVLMTVDFGKIILYISSLSFLGLGAqPPSPEWGAMLNAGRDYISS 234
Cdd:cd06261   96 LESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE-APGPGTGLLLIFAILFPGD 174

                        170
                 ....*....|....*.
gi 518299754 235 YPLLIIVPAFLITVTI 250
Cdd:cd06261  175 LGVAAAVALILLLLSL 190
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 83-201 2.76e-13

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 68.56  E-value: 2.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  83 VIIGVPLGLLAGYKKG-FVDTIIMRVIDIGLSIPEFVL-------------------MIAMASFFKPSIWNLV---IAIT 139
Cdd:COG0601  110 LLIGIPLGILAALRRGsWLDRLITVLALLGISIPSFWLglllillfavklgwlpvsgRVSPWEDFLDALRHLIlpaLTLA 189

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518299754 140 IIKWMTYTRLTRSIVSSEISKPYIQMAKLFNVPTHRIILKHFFPQVMPSVIVLMTVDFGKII 201
Cdd:COG0601  190 LGSLAGIARLTRSSMLEVLGQDYVRTARAKGLSERRVLLRHALRNALIPVVTVLGLQLGGLL 251
oppB PRK09471
oligopeptide ABC transporter permease OppB;
83-201 6.26e-04

oligopeptide ABC transporter permease OppB;


Pssm-ID: 181886 [Multi-domain]  Cd Length: 306  Bit Score: 40.43  E-value: 6.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518299754  83 VIIGVPLGLLAGYKKG-FVDTIIMRVIDIGLSIPEFVLMIAMASFFKPSI-------WN---------LVIAITIIKWMT 145
Cdd:PRK09471 109 VILGVSAGVIAALKQNtKWDYTVMGFAMTGVVIPSFVVAPLLVLIFAITLhwlpgggWNggalkfmilPMVALSLAYIAS 188

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 518299754 146 YTRLTRSIVSSEISKPYIQMAKLFNVPTHRIILKHFFPQVMPSVIVLMTVDFGKII 201
Cdd:PRK09471 189 IARITRGSMIEVLHSNFIRTARAKGLPMRRIILRHALKPALLPVLSYMGPAFVGII 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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