|
Name |
Accession |
Description |
Interval |
E-value |
| SLC5sbd_PutP |
cd11475 |
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ... |
5-467 |
0e+00 |
|
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271369 Cd Length: 464 Bit Score: 517.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 5 YTAFILYLLGMLAIGYYFYRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFTLMGVY 84
Cdd:cd11475 1 LITFIVYLLLMLGIGIYSYRKTKTLEDYFLGGRSLGPWVTALSAGASDMSGWLLLGLPGAAYASGLSAIWIAIGLILGAY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 85 LNWKLIAPRLRLETEKlNDAQTIPEYLHNRFKDNTNVLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESALIIG 164
Cdd:cd11475 81 LNWLFVAKRLRRYTEK-NDSITLPDYLENRFRDKSKLLRILSALIILIFFTIYAAAQLVAGGKLFESLFGIDYSTGLLIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 165 SIVIVSYTFMGGYLAVCWTDFFQGLMMALSLFITALSLFFLFSAPEQGVSYSQIMSE--ISLESLKPSNGWFLGLLSLSG 242
Cdd:cd11475 160 AVVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAALGGLSGLVAALAAIDPglLSPFGGDLGAGGLLAIISLLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 243 WCIGYLGQPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSYYF-EPKLDNAETVFIALAQAFYHPLVAGL 321
Cdd:cd11475 240 WGLGYFGQPHILVRFMAIRSPKEIKKARRIAMVWMILFLLGAVLVGLLGRALFpDGLLGDPETVFPVLAQELFPPWLAGI 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 322 IIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIAVALIGLALAFNkADQTLLSMVAFAWGGF 401
Cdd:cd11475 320 LLAAILAAIMSTADSQLLVCSSALTEDLYKAFLRKEASDKELVWVSRLAVLVIALIALLIALN-PPSSVFSLVSFAWAGL 398
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 520914081 402 GAAFGPVILLSLFWPAMTKAAAIFGMITGAAIALVWEILDGGIFDIFGVVPGFLMSTLVIVVSTLL 467
Cdd:cd11475 399 GAAFGPLLLLSLYWKRTTRQGALAGMIAGAVTVVVWKLLGLGIFGLYEIVPGFLASLLAIVVVSLL 464
|
|
| Na_Pro_sym |
TIGR02121 |
sodium/proline symporter; This family consists of the sodium/proline symporter (proline ... |
4-467 |
2.97e-172 |
|
sodium/proline symporter; This family consists of the sodium/proline symporter (proline permease) from a number of Gram-negative and Gram-positive bacteria and from the archaeal genus Methanosarcina. Using the related pantothenate permease as an outgroup, candidate sequences from Bifidobacterium longum and several from archaea are found to be outside the clade defined by known proline permeases. These sequences, scoring between 570 and -40, define the range between trusted and noise cutoff scores. [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273981 Cd Length: 487 Bit Score: 493.42 E-value: 2.97e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 4 LYTAFILYLLGMLAIGYYFYRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFTLMGV 83
Cdd:TIGR02121 3 ILITFGVYLIIMLLIGFYAYKKTTNLSDYVLGGRSLGPFVTALSAGASDMSGWLLMGLPGALYVTGLSELWIAIGLTIGA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 84 YLNWKLIAPRLRLETEKLNDAQTIPEYLHNRFKDNTNVLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESALII 163
Cdd:TIGR02121 83 YINWKFVAPRLRVYTEAAHNSITLPDFFENRFNDKSRLLRIISALIILVFFTIYTSSGLVAGGKLFESTFGLDYKTGLLI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 164 GSIVIVSYTFMGGYLAVCWTDFFQGLMMALSLFITALSLFFLFSAPEQGVSYSQIMSEISLESLKPSNgwFLGLLSLSGW 243
Cdd:TIGR02121 163 GALIIVIYTFFGGFLAVSWTDFVQGLLMFFALVLVPIVALFNLGGFGETLSAVAAINPHLLDMFKGAS--VIAIISLLAW 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 244 CIGYLGQPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSYYFEP----KLDNAETVFIALAQAFYHPLVA 319
Cdd:TIGR02121 241 GLGYFGQPHIIVRFMAIRSHKELPKARRIGMSWMILSLLGAIAVGLTGIAYFNKnphvELVDRETIFIVLSQILFHPWIA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 320 GLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIAVALIGLALAFNKaDQTLLSMVAFAWG 399
Cdd:TIGR02121 321 GILLAAILAAIMSTISSQLLVSSSALTEDFYKAFFKREASQKELVMVGRLSVLVIAIIAIILAMNP-NSSILNLVGYAWA 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 520914081 400 GFGAAFGPVILLSLFWPAMTKAAAIFGMITGAAIALVWEILDGGIFDIFGVVPGFLMSTLVIVVSTLL 467
Cdd:TIGR02121 400 GFGAAFGPVVLFSLYWKRMTRNGALAGMIIGAVTVIVWISKLGGSFGLYEIVPGFIISSIVIVVVSKL 467
|
|
| PRK15419 |
PRK15419 |
sodium/proline symporter PutP; |
4-481 |
3.08e-133 |
|
sodium/proline symporter PutP;
Pssm-ID: 185317 Cd Length: 502 Bit Score: 394.77 E-value: 3.08e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 4 LYTAFILYLLGMLAIGYYFYRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFTLMGV 83
Cdd:PRK15419 7 MLVTFCVYIFGMILIGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGISESWIAIGLTLGA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 84 YLNWKLIAPRLRLETEKLNDAQTIPEYLHNRFKDNTNVLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESALII 163
Cdd:PRK15419 87 WINWKLVAGRLRVHTEYNNNALTLPDYFTGRFEDKSRILRIISALVILLFFTIYCASGIVAGARLFESTFGMSYETALWA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 164 GSIVIVSYTFMGGYLAVCWTDFFQGLMMALSLFITALSLFFLFSAPEQGVSYSQIMSEISLESLKPSNgwFLGLLSLSGW 243
Cdd:PRK15419 167 GAAATILYTFIGGFLAVSWTDTVQASLMIFALILTPVIVIISVGGFGDSLEVIKQKSIENVDMLKGLN--FVAIISLMGW 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 244 CIGYLGQPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSYYFEPKLD-------NAETVFIALAQAFYHP 316
Cdd:PRK15419 245 GLGYFGQPHILARFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFNEHPAvagavnqNAERVFIELAQILFNP 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 317 LVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIAVALIGLALAFNkADQTLLSMVAF 396
Cdd:PRK15419 325 WIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKHASQKELVWVGRVMVLVVALVAIALAAN-PENRVLGLVSY 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 397 AWGGFGAAFGPVILLSLFWPAMTKAAAIFGMITGAAIALVWEILdgGIFDIFGVVPGFLMSTLVIVVSTLLsakndGKES 476
Cdd:PRK15419 404 AWAGFGAAFGPVVLFSVMWSRMTRNGALAGMIIGALTVIVWKQF--GWLGLYEIIPGFIFGSIGIVVFSLL-----GKAP 476
|
....*
gi 520914081 477 ETSLQ 481
Cdd:PRK15419 477 SAAMQ 481
|
|
| PutP |
COG0591 |
Na+/proline symporter [Amino acid transport and metabolism]; |
1-477 |
1.10e-115 |
|
Na+/proline symporter [Amino acid transport and metabolism];
Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 348.73 E-value: 1.10e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 1 MGYLYTAFILYLLGMLAIGYYFYRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFTL 80
Cdd:COG0591 2 STLDLIIIILYLLLLLGIGLYASRRTKSLEDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSALWYALGYA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 81 MGVYLNWKLIAPRLRLETeklndAQTIPEYLHNRFKdntNVLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESA 160
Cdd:COG0591 82 LGALLLALFFAPRLRRLG-----ALTIPEFLEKRFG---RGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 161 LIIGSIVIVSYTFMGGYLAVCWTDFFQGLMMALSLFITALSLFFLFSAPEQGVSYSQIMSEISLESLKPSNGWFLGLLSL 240
Cdd:COG0591 154 ILIGALIVLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALGGFGELFAALPAPGLLSLFPGLGFTGWLAFLGLF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 241 SGWCIGYLGQPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLG-SYYFEPKLDNAETVFIALAQAFYHPLVA 319
Cdd:COG0591 234 LAIGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLArALFPDLPLADPDLALPLLILELLPPGLA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 320 GLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIAVALIGLALAFNkADQTLLSMVAFAWG 399
Cdd:COG0591 314 GLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVGLLALLLALL-FPSSILDLVLLAWG 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 400 GFGAAFGPVILLSLFWPAMTKAAAIFGMITGAAIALVWEILDGGIFD---IFGVVPGFLMSTLVIVVSTLLSAKNDGKES 476
Cdd:COG0591 393 GLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWKLLGGPLGPfgwLYPILPGLLVSLLVFVVVSLLTKPPSEEVL 472
|
.
gi 520914081 477 E 477
Cdd:COG0591 473 E 473
|
|
| SLC5sbd |
cd10322 |
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
8-465 |
1.34e-84 |
|
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.
Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 267.88 E-value: 1.34e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 8 FILYLLGMLAIGYYFYRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFTLMGVYLNW 87
Cdd:cd10322 6 VVVYLALLLGIGLYASKKVKSSEDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYILGAALGALLLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 88 KLIAPRLRLETeklndAQTIPEYLHNRFKDNTnvLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESALIIGSIV 167
Cdd:cd10322 86 LFLAPRLRRLG-----KTTIPETILERYYSKG--LRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVIIAAVI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 168 IVSYTFMGGYLAVCWTDFFQGLMMALSLFITALSLFFLFSAPEQGVSYSQIMSEISLESLKPSNGWFLGLLSLSGWCIGY 247
Cdd:cd10322 159 VILYTVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGGGGFSALAAALPALLLALGPGGGLGWSTILSLILLTGLGV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 248 LGQPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSYYFePKLDNAETVFIALAQAFYHPLVAGLIIAGVL 327
Cdd:cd10322 239 LALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALF-PDLENPDLALPTLINSLLPPGLAGLVLAGLL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 328 AAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIAVALIGLALAFNKADqtLLSMVAFAWGGFGAAFGP 407
Cdd:cd10322 318 AAAMSTADSLLLAASTLFTRDIYKPLINPKASDKKLLRVSRIAVVVVGVLALLLALLPPS--ILLLLSLAAGLLAAALFP 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 520914081 408 VILLSLFWPAMTKAAAIFGMITGAAIALVWEIL-DGGIFDIFGVVPGFLMSTLVIVVST 465
Cdd:cd10322 396 PLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLpLASPLGIDPIIPALLVSLIVFVVVS 454
|
|
| SSF |
pfam00474 |
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ... |
32-430 |
6.29e-80 |
|
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.
Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 254.19 E-value: 6.29e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 32 YILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFTLMGVYLNWKLIAPRLRLeteklNDAQTIPEYL 111
Cdd:pfam00474 1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRN-----LGAYTMPDYL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 112 HNRFKDNtNVLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESALIIGSIVIVSYTFMGGYLAVCWTDFFQGLMM 191
Cdd:pfam00474 76 RKRFGGK-RILVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLM 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 192 ALSLFITALSLFFLFSAPEQGVSYSQIMSEISLESLKPSNGW----FLGLLSLS-GWCIGYLGQPHVLVRFMSVRSVEDV 266
Cdd:pfam00474 155 LFGTIILMIIVFHEVGGYSSAVEKYMTADPNGVDLYTPDGLHilrdPLTGLSLWpGLVLGTTGLPHILQRCLAAKDAKCI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 267 KVSRRIAMVWSTITMMSAVVVGVLGSYYF-------EPKLDNAETVFIALAQAFYHPLVAGLIIAGVLAAIMSTIDSQLL 339
Cdd:pfam00474 235 RCGVLILTPMFIIVMPGMISRGLFAIALAganpracGTVVGCSNIAYPTLAVKLGPPGLAGIMLAVMLAAIMSTLTSQLL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 340 VCSTTISEDLYKTYLRKN-ASDKEVLLVARLGVIAVALIGLALAFNKADQTLLSMVAFAWGGFGAAFGPVILLSLFWPAM 418
Cdd:pfam00474 315 SSSSAFTHDLYKNIRRKAsATEKELVGRSRIIVLVVISLAILLAVQPAQMGIAFLVQLAFAGLGSAFLPVILLAIFWKRV 394
|
410
....*....|..
gi 520914081 419 TKAAAIFGMITG 430
Cdd:pfam00474 395 NEQGALWGMIIG 406
|
|
| PanF |
COG4145 |
Na+/panthothenate symporter [Coenzyme transport and metabolism]; |
3-472 |
2.99e-75 |
|
Na+/panthothenate symporter [Coenzyme transport and metabolism];
Pssm-ID: 443316 Cd Length: 484 Bit Score: 244.36 E-value: 2.99e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 3 YLYTAFILYLLGMLAIGYYFYRK---TNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFT 79
Cdd:COG4145 5 AILIPLLIYLLLVLGIGIYASRKrskGSFLEEYFLGSRSMGGFVLAMTLAATYTSASSFIGGPGAAYKYGLGWVLLAMIQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 80 LMGVYLNWKLIAPRLRLETEKLNdAQTIPEYLHNRFkdNTNVLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYES 159
Cdd:COG4145 85 VPTAFLTLGVLGKKFAILGRKYN-AVTLADWLRARY--QSKALVLLAALLLLLFFIAFMVAQFVGGARLLETVTGISYTT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 160 ALIIGSIVIVSYTFMGGYLAVCWTDFFQGLMMALSLFITalslffLFSAPEQGVSYSQIMSEIS-----LESLKPSNGWF 234
Cdd:COG4145 162 GLLIFGVTVVLYTTIGGFRAVVLTDAIQGIIMLVGTVLL------LIGVISAGGGIENIMSTLAaidpnLVSPTGPDGFL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 235 LGLLSLSGW---CIGYLGQPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSYYFePKLDNAETVFIALAQ 311
Cdd:COG4145 236 PRPFVISFWilvGFGVIGLPHTAVRCMAYKDSKSLHRAMIIGTIVVGLLMFGMHLIGVLGRAVL-PDLTVPDQVIPTLMV 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 312 AFYHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNAS--DKEVLLVARLGVIAVALIGLALAFNKADqT 389
Cdd:COG4145 315 KVLPPFLAGIFLAGPLAAIMSTVDSLLLQASSTIVKDLYLNYINPKASenEKKLKRLSKLVTLVLGLIVFLLALNPPD-L 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 390 LLSMVAFAWGGFGAAFGPVILLSLFWPAMTKAAAIFGMITGAAIALVWEILDGGIFDIFGVVPGFLMSTLVIVVSTLLSA 469
Cdd:COG4145 394 IIWLNLFAFGGLEAAFFWPLVLGLYWKRANATGAIASMLVGVASYFLLYYGNPKIFGFHAIVPSLLISLIAFLIGSLLGK 473
|
...
gi 520914081 470 KND 472
Cdd:COG4145 474 PPD 476
|
|
| SLC5sbd_PanF |
cd10327 |
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ... |
8-472 |
1.02e-65 |
|
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212037 Cd Length: 472 Bit Score: 219.00 E-value: 1.02e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 8 FILYLLGMLAIGYYFYR-----KTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFTLMG 82
Cdd:cd10327 5 IIIYLVILLGIGFYARRskkrrSGDFLEEYFIGGRSMGGFVLAMTLVATYTSASSFIGGPGAAYKIGLGWVLLAMIQVPT 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 83 VYLNWKLIAPRLRLETEKLNdAQTIPEYLHNRFkdNTNVLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESALI 162
Cdd:cd10327 85 GFLTLGVLGKKFAIIARKIN-AVTIIDYLRARY--NSKALVVLSSLALIVFFIAAMVAQFIGGARLLEAVTGLSYVTGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 163 IGSIVIVSYTFMGGYLAVCWTDFFQGLMMALSlfiTALSLFFLFSApeqGVSYSQIMSEISLESLKPSNGWFLGLLS--- 239
Cdd:cd10327 162 IFGLTVILYTTIGGFRAVALTDAIQGIVMIIG---TVLLLVGVLAA---GGGMEAIMATLAEIDPNLLTPFGPGFLSppy 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 240 -LSGW---CIGYLGQPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSYYFePKLDNAETVFIALAQAFYH 315
Cdd:cd10327 236 iLSFWvlvGFGVIGLPQTAVRCMGYKDSKSMHRAMIIGTVVVGFLMLGMHLAGVLGRAVL-PDLEVPDKVIPTLALKVLP 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 316 PLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRK--NASDKEVLLVARLGVIAVALIGLALAFNKADqTLLSM 393
Cdd:cd10327 315 PWLAGLFLAGPLAAIMSTVDSQLILASSAIVKDLYLNYKNKekKTSEKKVKRISLIITIILGLLVFLLAINPPD-LIVWL 393
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 520914081 394 VAFAWGGFGAAFGPVILLSLFWPAMTKAAAIFGMITGAAIALVWEILDGGIFDIFGVVPGFLMSTLVIVVSTLLSAKND 472
Cdd:cd10327 394 NLFAFGGLEAAFFWPLVLGLYWKRANATGALASMVVGLVSYILITYLKIKILGLHPIVPSLLLSLIAFIIVSLATKKPD 472
|
|
| sss |
TIGR00813 |
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
35-430 |
6.26e-65 |
|
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 215.24 E-value: 6.26e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 35 GSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVftlmgVYLNWKLIAPRLRLETEKLNDAQTIPEYLHNR 114
Cdd:TIGR00813 1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYEL-----GALVLLIILGWLFVPIFINNGAYTMPEYLEKR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 115 FKDNtnVLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESALIIGSIVIVSYTFMGGYLAVCWTDFFQGLMMALS 194
Cdd:TIGR00813 76 FGKR--ILRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 195 LFITALSLFFLFSAPEQgvsYSQIMSEISLESLKPSNGW---FLGLLSLSGWCIGYLGQPHV----------LVRFMSVR 261
Cdd:TIGR00813 154 TFILPVFAFSEVGGLGT---FVEKASQAAPTNPSPDDLYdffRDPSTSDLPWGAGVFGLPHValwywtnqviVQRCLAAK 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 262 SVEDVKVSRRIAMVWSTITMMSAVVVGVLGSYYF--------EPKLDNAETVFIALAQAFYHPLVAGLIIAGVLAAIMST 333
Cdd:TIGR00813 231 SAKHAKKGCLISGVLKLLPMFGAVLPGLIARALYtdidpalaGAVNQNSDQAYPLLVQELMPPGLAGLFLAAILAAVMST 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 334 IDSQLLVCSTTISEDLYKTYLRKNAS-DKEVLLVARLGVIAVALIGLALAFNKADQtLLSMVAFAWGGFGAAFGPVILLS 412
Cdd:TIGR00813 311 LSSQLNSASTVFTMDLYKKIIRPNASgEKKIVMRGRIAVLVAAVIAGFVAAAQGGQ-VLQYVQEAFGGLGAPFLPVFLLG 389
|
410
....*....|....*...
gi 520914081 413 LFWPAMTKAAAIFGMITG 430
Cdd:TIGR00813 390 IFWKRMNAKGALAGMIAG 407
|
|
| SLC5sbd_u4 |
cd11480 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
6-437 |
7.61e-55 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271374 Cd Length: 488 Bit Score: 190.79 E-value: 7.61e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 6 TAFILYLLGMLAIGYYFYRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFTLMGVYL 85
Cdd:cd11480 2 GLFFVFVTITLYITIWAARRTRSTSDFYVAGRGVPPVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLAYAIGWTGGYVL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 86 NWKLIAPRLRleteKLNdAQTIPEYLHNRFKDNTnvLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESALIIGS 165
Cdd:cd11480 82 LLLLVAEPLR----NFG-KYTVPDFLGARLGSRP--VRLVAAVSTLVISFFYLVAQMVGAGLLLSLLLGIPYEVGVVVVG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 166 IVIVSYTFMGGYLAVCWTDFFQGLMMALSLFITALSLFFLFSAPEQGVSYSQIMSEISLESLKPSNGWFLGLLSLSGW-- 243
Cdd:cd11480 155 ALMIVYVVLGGMRATTWVQIIQYVLLLGAFLVPAILVLARFGGNPLGAGPGLLGLAAAAASGAGEAYLAPGLLLTDPLdv 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 244 -------CIGYLGQPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSYYFEPKLDNAE----------TVF 306
Cdd:cd11480 235 isltlalMLGTAGLPHVLMRFYTVPDARAARKSVVWALGFIGLFYLLAPALGFGARALVGPDVIGAPiageldgggdMAV 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 307 IALAQAFYHP-LVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIAVALIGLALAFNK 385
Cdd:cd11480 315 LLLPEIAGLGdLLLALVAAGAFAAILATVAGLLLAAASALAHDLYAGVIRPGASERREVRVARIAAVVVGVIAILLALLF 394
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 520914081 386 ADQTLLSMVAFAWGGFGAAFGPVILLSLFWPAMTKAAAIFGMITGAAIALVW 437
Cdd:cd11480 395 PPQNVAFLVALAFAIAASAFFPVLVLGIFWRRFTTRGAIAGMLVGLLVSLVL 446
|
|
| ActP |
COG4147 |
Na+(or H+)/acetate symporter ActP [Energy production and conversion]; |
6-469 |
4.61e-52 |
|
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
Pssm-ID: 443318 Cd Length: 526 Bit Score: 184.21 E-value: 4.61e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 6 TAFILYLLGMLAIGYYFYRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFTLMGVYL 85
Cdd:COG4147 16 GIFLVFVTFTLYITIWAARRTKSTSDFYVAGRGVTGVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLIYSIGWLVGYVL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 86 NWKLIAPRLRleteKLNdAQTIPEYLHNRFKDNTnvLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESALIIGS 165
Cdd:COG4147 96 LLLLLAEYLR----NFG-KFTVPDFLGDRFYSRP--ARLVAAISTLVVSFFYLIAQMVGAGVLISLLLGVDYEVAVVIVG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 166 IVIVSYTFMGGYLAVCWTDFFQ-GLMMALSLFITAL-------SLFFLFSAPEQGVSYSQIMSEISLESLKPSNGWFLGL 237
Cdd:COG4147 169 VLMIVYVVLGGMKGTTWVQIIKaVLLIFAYTVPAVLvlaqfgfNPLPLLAKAAEVHDLGAAYLEPGGLVKSPLDFISLGL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 238 lslsGWCIGYLGQPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSYYFEPKLDNAETVFI---------- 307
Cdd:COG4147 249 ----ALMLGTAGLPHILMRFFTVPDAKEARKSVGWALGFIGLFYLTAPALGFGARALVGPLPEWFDTGLIgaadgggnma 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 308 --ALAQAFYHP-LVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIAVALIGLALAFN 384
Cdd:COG4147 325 vlALAEIAGGGnWLLGLVAAGAFATILAVVAGLLLAIASAISHDLYANVIKGKATEKEELRVARIAAVVIGVVAILLGIN 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 385 KADQTLLSMVAFAWGGFGAAFGPVILLSLFWPAMTKAAAIFGMITGAAIALVWEIL------DGGIFDIFGVV-PGF--- 454
Cdd:COG4147 405 APPQNVAFLVALAFALAASANFPVLLLSIFWKRFNTRGAVAGMLVGLISALVLIVLspfvwvLGVDAALFPLEnPGLvsm 484
|
490
....*....|....*
gi 520914081 455 LMSTLVIVVSTLLSA 469
Cdd:COG4147 485 PLGFLVAIVVSLLTP 499
|
|
| panF |
TIGR02119 |
sodium/pantothenate symporter; Pantothenate (vitamin B5) is a precursor of coenzyme A and is ... |
9-470 |
1.20e-51 |
|
sodium/pantothenate symporter; Pantothenate (vitamin B5) is a precursor of coenzyme A and is made from aspartate and 2-oxoisovalerate in most bacteria with completed genome sequences. However, some pathogens must import pantothenate. This model describes PanF, a sodium/pantothenate symporter, from a larger family of Sodium/substrate symporters (pfam00474). Several species that have this transporter appear to lack all enzymes of pantothenate biosynthesis, namely Haemophilus influenzae, Pasteurella multocida, Fusobacterium nucleatum, and Borrelia burgdorferi. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A, Transport and binding proteins, Other]
Pssm-ID: 131174 Cd Length: 471 Bit Score: 181.85 E-value: 1.20e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 9 ILYLLGMLAIGYYFYRKTNT----VSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFTLMGVY 84
Cdd:TIGR02119 8 IIYLVTVFLIAIYASKRVQStdsfLNEYFLGGRSMGGFVLAMTLVATYGSASSFIGGPGIAYNYGLGWVLLAMIQVPTGY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 85 LNWKLIAPRLRLETEKLNdAQTIPEYLHNRFkdNTNVLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESALIIG 164
Cdd:TIGR02119 88 FVLGVLGKKFAIISRKYN-AITINDVLKARY--NNKFLVWLSSISLLVFFFSAMVAQFIGGARLIESLTGLSYLTALFIF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 165 SIVIVSYTFMGGYLAVCWTDFFQGLMMALSLFITALSLFFLFSAPEQGVsysQIMSEISLESLKP--SNGWFLGLLSLSG 242
Cdd:TIGR02119 165 SSSVLIYTTFGGFRAVALTDAIQGIVMFTGTTILLIAVIKAGGGVEKIM---EKLKDIDPNLITPfgGDGGLTKPFVASF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 243 W---CIGYLGQPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSYYFePKLDNAETVFIALAQAFYHPLVA 319
Cdd:TIGR02119 242 WilvGIGVIGLPQTAVRCMSYKDSKAMHRAMIIGTIVVGIIMLGMHLAGVLGRAVI-PDLTVPDKVIPLLAIKVLPPILA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 320 GLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIAVALIGLALAFNKADqTLLSMVAFAWG 399
Cdd:TIGR02119 321 GIFLAAPMAAIMSTVNSLLLQSSSTIIKDLYLNYIPKEAKESKIKKISMCITLIIGLLVIIAAIKPPD-LIIWLNLFAFG 399
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 520914081 400 GFGAAFGPVILLSLFWPAMTKAAAIFGMITGAAIALVWEILDGGIFDIFGVVPGFLMSTLVIVVSTLLSAK 470
Cdd:TIGR02119 400 GLEAAFIWPIVLGLYWKRANATGALASMIVGVGSYITLESFKPKIFGLHNIVPSLVFALIAFIIGSLFGKK 470
|
|
| SLC5sbd_CHT |
cd11474 |
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
6-467 |
3.92e-42 |
|
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 155.76 E-value: 3.92e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 6 TAFILYLLGMLAIGYYFYRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVF------T 79
Cdd:cd11474 2 IGVILYYLLILGIGLWASRRVKSSEDFLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLGGVAQDPFgyalclI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 80 LMGVylnwkLIAPRLRleteKLNdAQTIPEYLHNRFKDNTNVLqltSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYES 159
Cdd:cd11474 82 LGGL-----FFAKPMR----RMG-LLTLGDFFRQRYGRRVEVL---LSIPAVLSYLGWVAAQLVALGLVLSVILGLPVET 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 160 ALIIGSIVIVSYTFMGGYLAVCWTDFFQGLMMALSLFItalSLFFLFSAPEQGVSYSQIMSEisLESLKPSNGWFLGLLS 239
Cdd:cd11474 149 GILISAAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLV---LVPFVLTNPGGVDIASAAAAG--KLRFFPWLGTKSDWLI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 240 -LSGWCIGYLG---QPHVLVRFMSVRSVEDVKVSRRIAMVWSTI-----TMMSAVVVGVLGSYYFEPKLDNAETVFIALA 310
Cdd:cd11474 224 wIDAWLTLGLGsipQQDVFQRVLSAKSEKTAQRLSLLAGVGYLLfaippLLIGLAAASIDPSLTQYGLEEDAQLILPLLL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 311 QAFYHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIAVALIGLALAFNKadQTL 390
Cdd:cd11474 304 QYLTPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVVFGAIATLMALTV--ESI 381
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 520914081 391 LSMVAFAWG-GFGAAFgPVILLSLFWPAMTKAAAIFGMITGAAIALVWEILDGGIFDIFGV-VPGFLMSTLVIVVSTLL 467
Cdd:cd11474 382 YGLVELASDlVLVGLF-VPLLAGLYWKRANTYGALAAIIVGLVLRLLGGELLLGLPADIPPqLQGFPFSTLAMVIGSLL 459
|
|
| SLC5sbd_NIS-like_u3 |
cd11495 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
5-467 |
7.76e-40 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271386 [Multi-domain] Cd Length: 473 Bit Score: 149.61 E-value: 7.76e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 5 YTAFILYLLGMLAIGYYFYRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAG----GLGSVWIIVFTL 80
Cdd:cd11495 6 YLVLVIYLLAMLGIGLYFSKKQKSTDDYFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKAYATdwnyFVGSLSIIIAAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 81 MGVYlnwkLIAPRLRleteKLNDAqTIPEYLHNRFKdntNVLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESA 160
Cdd:cd11495 86 LAAY----FFVPFFR----RLNVT-SAYEYLEKRFG---PWARVYGSLLFILFQLGRMGIVLYLPALALSAVTGINPYII 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 161 LIIGSIVIVSYTFMGGYLAVCWTDFFQGLMMALSLFitaLSLFFLFSAPEQGVsySQIMSE-ISLESLKPSNgWFLGLLS 239
Cdd:cd11495 154 IILMGVLCIIYTVLGGIEAVIWTDVIQGVVLLGGAL---LCLIILLFSIPGGF--GEVFDIaIANGKFSLGD-FSFSLTE 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 240 LSGWCI----------GYLGQPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVG-VLGSYY-----FEPKLDNAE 303
Cdd:cd11495 228 STIWVIfiggifnnlqSYTSDQDVVQRYLTTKSIKEAKKSLWTNALLALPVALLFFGIGtALYVFYqqhpeLLPAGINGD 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 304 TVFiALAQAFYHPL-VAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKtYLRKNASDKEVLLVARLGVIAVALIG--LA 380
Cdd:cd11495 308 AVF-PYFIVTQLPVgVAGLIIAAIFAAAMSTISSSLNSVATCITTDFYK-RLSPDPSDKQYLKVARLITLLVGLLGtlVA 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 381 LAFNKADQ-TLLSMVAFAWGGFGAAFGPVILLSLFWPAMTKAAAIFGMITGAAIALVWEILDGGIFDIFGVVPGFLMSTL 459
Cdd:cd11495 386 LYLANAGVkSLLDAFNTLTGLFGGGLAGLFLLGIFTKRANAKGALVGIIVSIIVIFWISLLYTPIHFFLYSVIGTLVCFV 465
|
....*...
gi 520914081 460 VIVVSTLL 467
Cdd:cd11495 466 VGYVVSLL 473
|
|
| YidK |
COG4146 |
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ... |
5-436 |
4.96e-39 |
|
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];
Pssm-ID: 443317 [Multi-domain] Cd Length: 444 Bit Score: 146.83 E-value: 4.96e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 5 YTAFILYLLGMLAIGYYFYR--KTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSV---WI--IV 77
Cdd:COG4146 8 YIVFLLYFLLVAGIGYWVSRkkKEKTSEDYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYATGLAVAayeWMaaIA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 78 FTLMGVYLnwkliAPR-LRleteklNDAQTIPEYLHNRFKDNT----NVLQLTSSLVTLLFFTLYvaaglsGGAVLFEST 152
Cdd:COG4146 88 LIILALFF-----LPFyLK------SGIYTMPEFLEKRYDRRTrtilSILFLVSYVFVNLPSVLY------AGALALNTI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 153 FGLSYESALIIGSIVIVSYTFMGGYLAVCWTDFFQG-LMMALSLFITALSLFFLfSAPEQGVSYSQIMSEIS--LESLKP 229
Cdd:COG4146 151 FGVPLWISVIGLGIIAGIYTIFGGLKAVAYTDVIQGiGLIIGGLLITVLGLDAV-GDGSVLAGWSALLKVPPekFNMIGP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 230 SN-------GWFLGL--LSLSGWCIG-YLGQphvlvrfmSVRSVEDVKVSRRIAMVWSTITMMSAVVV---GVLGSYYFE 296
Cdd:COG4146 230 ADdpdlpwlGIFTGMpiLNLFYWGTNqYIVQ--------RALGAKNLKEAQKGVLFAGFLKLLIPFIVvlpGIIAFVLFP 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 297 PKLDNAETVFIALAQAFYHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIAVAL 376
Cdd:COG4146 302 DGLDNPDQAYPTLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKYFNPNASEKQLVKVGRIATVVLAV 381
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 520914081 377 IGLALA-----FNKADQTLLSMVAFAWGGFGAAFgpviLLSLFWPAMTKAAAIFGMITGAAIALV 436
Cdd:COG4146 382 IAILIAplignADGLFQYIQEVTGFFSPPILAVF----LLGLFWKRVTAKAAKVALIAGIVLSIL 442
|
|
| SLC5sbd_u1 |
cd11477 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
5-468 |
5.13e-39 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271371 Cd Length: 493 Bit Score: 147.73 E-value: 5.13e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 5 YTAFILYLLGMLAIGYYFYRK-TNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFTLMGV 83
Cdd:cd11477 3 WLVIALYFLLMLGIGLWFSKRaSKSTSDFFLGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAGNWIWWLWAVAG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 84 YLNWKLIAPRLRlETEKLNDAQTIPEYLHNRFkdnTNVLQLTSSLVTLLFFTLYVAAGLSGGAVLF-ESTFGLSYESALI 162
Cdd:cd11477 83 LIGAFVFARRWR-RLRVLTDGEFPEERYGGRY---GAPLRQFYAVYFALLSNVDILAWVFLAAIKVsAVFGPWDPWLTIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 163 IGSIVIVSYTFMGGYLAVCWTDFFQ-GLMMALSLFITALSLFFLFSAPEQGVSYSQIMSEISLESLKPSN-GWFLGLLSL 240
Cdd:cd11477 159 ILGLITLIYTVIGGLWAVVVTDVVQfVIAMAASIAVAVLALNAVGGPGGLFAQLPEGHLDLFGSGLGASGfYITFFFILF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 241 SGW--CIGYLGQPHVLVRFMSVRSVEDVKVSRRIA----MVWSTITMMSAVVVGVLgsYYF-EPKLDNAETVFIALAQAF 313
Cdd:cd11477 239 FGWypLSYSGGGWYLAQRYLSAKSEKAAKAAAWLFaalyLVRPWPWMLPALAALVL--YPDlDDPEADFELAYPMMIKEY 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 314 YHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIAVALIGLALAFNkadQTLLSM 393
Cdd:cd11477 317 LPAGLLGLVLAGLLAATMSTVSTHLNWGAAYLVNDIYKRFIKPNASEKHLLKVGRLATVLFGLLSIVVALA---SDSIGG 393
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 520914081 394 VAFAWGGFGAAFGPVILLSLFW---PAMT-KAAAIFGMITGAAIALVWEILDGGIFDIFGVVPGFLMSTLVIVVSTLLS 468
Cdd:cd11477 394 AFWIVLALGAGLGGPLILPWLWwrfNAWTeIWAMIASIIVGLVVSVLLKVFGLPEDFLFSFLVPVLLSLVVWLAVTLLT 472
|
|
| Na_symport_lg |
TIGR03648 |
probable sodium:solute symporter, VC_2705 subfamily; This family belongs to a larger family of ... |
7-464 |
6.93e-35 |
|
probable sodium:solute symporter, VC_2705 subfamily; This family belongs to a larger family of transporters of the sodium:solute symporter superfamily, TC 2.A.21. Members of this strictly bacterial protein subfamily are found almost invariably immediately downstream from a member of family TIGR03647. Occasionally, the two genes are fused.
Pssm-ID: 274698 Cd Length: 552 Bit Score: 137.00 E-value: 6.93e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 7 AFILYLlgmlAIGYYFyrKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGL-GSVWIIVFTlMGVYL 85
Cdd:TIGR03648 8 TFALYI----GIGIWS--RAGSTSEFYVAGRGVPPVANGMATAADWMSAASFISMAGLIAFLGYdGLAYLMGWT-GGYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 86 NWKLIAPRLRleteKLNdAQTIPEYLHNRFkdNTNVLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESALIIGS 165
Cdd:TIGR03648 81 LALLLAPYLR----KFG-KYTVPDFIGDRY--YSNTARLVAVICAIFISFTYVAGQMRGVGVVFSRFLEVDFETGVFIGM 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 166 IVIVSYTFMGGYLAVCWTDFFQG--LMMALSLFITALSLF--------FLFSAPEQGVSYSQIMSEISLESL-------- 227
Cdd:TIGR03648 154 AIVFFYAVLGGMKGVTWTQVAQYivLIVAYLVPAIFISLKltgnpvpqLGYGSALSGVYLLDKLDELEVDLGfaeytepf 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 228 --KPSNGWFLGLLSLSgwcIGYLGQPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSY------------ 293
Cdd:TIGR03648 234 gsKSRINVFALTLALM---VGTAGLPHVIVRFYTVPKVRDARWSAGWALFFIALLYTTAPAVAAFARYnlittvngtpya 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 294 --------------------------YFEPKLDNAETV---FIALAQ---AFYHPLVAGLIIAGVLAAIMSTIDSQLLVC 341
Cdd:TIGR03648 311 elpgwvanwektgllkfedkngdgilQYSGDAGNELTIdrdIIVLATpeiAGLPYWVIGLVAAGGLAAALSTAAGLLLVI 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 342 STTISEDLYKTYLRKNASDKEVLLVARLGVIAVALIGLALAFNKAdQTLLSMVAFAWGGFGAAFGPVILLSLFWPAMTKA 421
Cdd:TIGR03648 391 SSAISHDLYYRIINPNASEKQRLLVARIALVVAAVIAGYFGLNPP-GFIAQVVAFAFGLAAASFFPALVLGIFWKRMNRE 469
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 520914081 422 AAIFGMITGAAIALVWEILDGGIFDIFGVVPGFLMSTLVIVVS 464
Cdd:TIGR03648 470 GAIAGMLTGLGFTFSYIVYFKPWGFIGTNPGANVPENWWFGIS 512
|
|
| SLC5sbd_u3 |
cd11479 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
5-470 |
1.18e-34 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271373 Cd Length: 454 Bit Score: 135.04 E-value: 1.18e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 5 YTAFILYLLGMLAIGYYFYRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFTLMGVY 84
Cdd:cd11479 3 YGVIALYFAAMIAIGWWGMRRAKTSEDYLVAGRRLGPGLYLGTMAAVVLGGASTIGGVGLGYQYGISGMWLVVAIGLGIL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 85 LNWKLIAPRLRleteKLNdAQTIPEYLHNRFKDNTNVLqltSSLVTLLF-FTLYVAAGLSGGAVlFESTFGLSYESALII 163
Cdd:cd11479 83 ALSLLLAKRIA----RLK-VYTVSEVLELRYGPSARVI---SALVMLAYtLMVAVTSTIAIGTV-FSVLFGLPRTLSILV 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 164 GSIVIVSYTFMGGYLAVCWTDFFQGLMMALSLFITALSLfflfsAPEQGVSYSQIMSEISLESLKPSN-GWFLGLLSLSG 242
Cdd:cd11479 154 GGGIVVLYSVLGGMWSITLTDIIQFVIKTIGIFLLLLPL-----ALSKAGGLSGLQEKLPASYFDLTSiGWDTIVTYFLL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 243 WCIGYLGQPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSYYFePKLDNAETVFIALAQAFYHPLVAGLI 322
Cdd:cd11479 229 YFFGILIGQDIWQRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAVLL-PDLANPQNAFATMAQEVLPVGLRGLV 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 323 IAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIAVALIGLALAFNKADQTLLSMVAFAWgGFG 402
Cdd:cd11479 308 LAAALAAMMSTASGALLASSTVLTNDVLPRLRRKNESERSEVRLSRLFTLLLGVVVIVIAVLVNDVVAALTIAYAI-LVG 386
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 520914081 403 AAFGPvILLSLFWPAMTKAAAIFGMITGAAIALVWEILDgGIFDIFGVVPGFLMSTLVIVVSTLLSAK 470
Cdd:cd11479 387 GLLVP-ILGGLFWKRATGAGALASMVAGSVVVLAGMAVD-GLLANTPIYYGLAVSLVAFVAVSLLTRP 452
|
|
| SLC5sbd_u2 |
cd11478 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
5-440 |
8.73e-32 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271372 Cd Length: 496 Bit Score: 127.40 E-value: 8.73e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 5 YTAFILYLLGMLAIGYYFYRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGG--------LGSVWII 76
Cdd:cd11478 3 YLIVAVYFVFVLGIGFYLKRKVKTSEDFFLSGRSLPAWITGLAFISANLGALEIVGMSANGAQYGiatvhfywIGAIPAM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 77 VFT---LMGVYLNWKliaprlrleteklndAQTIPEYLHNRFKDNTNVLqltSSLVTLLFFTLYVAAGLSGGAVLFESTF 153
Cdd:cd11478 83 VFLgivMMPFYYGSK---------------VRSVPEYLKLRFNKSTRLL---NAVSFAVMTILMSGINLYALALVLNVLL 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 154 GLSYESALIIGSIVIVSYTFMGGYLAVCWTD---FFQGLMMALSLFITALSLF----FLFSAPEQGVSYSQIMSEISLES 226
Cdd:cd11478 145 GWPLWLSIILSAAIVLAYTTLGGLTSAIYNEvlqFFLIVAGLIPLVIIGLIKVggwdGLSEKIDANGPPGWNGLSWGPQG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 227 LKPSNGWFLGL---------LSLSGWCIGYLgqphVLVRFMSVRSVEDVKVSRRIA----MVWSTITMMSAVVVGVLGSY 293
Cdd:cd11478 225 SQSTNPMGVNLglvfglgfvLSFGYWTTNFL----EVQRAMAAKDLSAARRTPLIAafpkMFIPFLVILPGLIALVLVPE 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 294 YFEPKLDNAETVFIALAQAFYHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIA 373
Cdd:cd11478 301 LGASGGLDYNQALPYLMAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIYQTYIVKDAPDKHYLKVGRIATVV 380
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 520914081 374 VALIGLALAF--------NKADQTLLSMvafawggFGAAFGPVILLSLFWPAMTKAAAIFGMITGAAIALVWEIL 440
Cdd:cd11478 381 GVLISIGTAYiassfnniMDYLQLLFSF-------FNAPLFATFLLGMFWKRATPWGGFWGLLAGTASAIVLYGL 448
|
|
| SLC5sbd_DUR3 |
cd11476 |
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ... |
7-468 |
3.23e-28 |
|
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271370 Cd Length: 493 Bit Score: 116.92 E-value: 3.23e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 7 AFILYLLGMLAIGYYFYRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGL---------GSVWIIV 77
Cdd:cd11476 10 LFALLMVFITRLLKRYRGKNQSSEEFMTAGRSVGTGLTAAAIVSSWTWAATLLQSATVAYQYGVsgpfwyasgATLQILL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 78 FTLMGVYLnwKLIAPRlrleteklndAQTIPEYLHNRFKDNTNVLQLTSSLVTLLFFTlyvAAGLSGGAVLFESTFGLSY 157
Cdd:cd11476 90 FAPLAIRI--KRLAPN----------AHTLLEIVRARYGTAAHLVFLVFALFTNVIVL---AMLLLGGSAVVNALTGMPI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 158 ESALIIGSIVIVSYTFMGGYLAVCWTDFFQglMMALSLFITALSLFFLFSAPEQGVS--YSQIMSEISLESLKPSNGWFL 235
Cdd:cd11476 155 VAASFLIPLGVLLYTLFGGLRATFLTDYIH--TVIILIILLVFAFAVYTSSDIGSPSkvYDLLQEAAPDLPVEGNQGSYL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 236 GLLSLSGwciGYLGQPHVL-------------VRFMSVRSVEDVKVSRRIAMVWSTI-----TMMSAVVVGVLGSYYFEP 297
Cdd:cd11476 233 TFKSKAG---LIFGIINIVgnfgtvfldqgywQRAIAARPSAAVKGYFLGGLAWFAIpfllaTTLGLAALALGLNPTFEE 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 298 KldNAETVFIALAQAFYHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIAVALI 377
Cdd:cd11476 310 V--SAGLVLPYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTYDIYRTYINPNATGKQLLRVSRIAVIGFGLF 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 378 --GLALAFNKADQTLLSMVAFAWGGFGAAFGPVIlLSLFWPAMTKAAAIFGMITGAAIAL-VW---------EILDGGIF 445
Cdd:cd11476 388 mgGLAVGLNYIGISLGWLLLFMGILIGSAVFPVA-LGLYWRRQTGTAAVVSPIAGLVAGLaVWlvtaksyygEVNVDTTG 466
|
490 500
....*....|....*....|....
gi 520914081 446 DIFGVVPGFLMSTLV-IVVSTLLS 468
Cdd:cd11476 467 GNYPMLAGNLVALFSpAIVSVLLS 490
|
|
| SLC5sbd_SGLT1-like |
cd10329 |
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ... |
5-467 |
1.14e-26 |
|
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271363 Cd Length: 538 Bit Score: 113.05 E-value: 1.14e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 5 YTAFILYLLGMLAIGYY-FYRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSV---WIIVFTL 80
Cdd:cd10329 1 IVIIAVYFVAVIAIGLWsSRKKRSTVSGYFLAGRSMGWPVIGASLFASNIGSSHLVGLAGSGAASGIAVGnyeWNAAFVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 81 mgVYLNWkLIAPR-LRLETeklndaQTIPEYLHNRFKDNTNVLQLTSSLVTLLFftLYVAAGLSGGAVLFESTFGLSYES 159
Cdd:cd10329 81 --LLLGW-VFLPFyIRSGV------STMPEFLEKRFGGRSRVYLSVLSLILYVF--TKISVDLYAGALVIKQLLGWDLYL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 160 ALIIGSIVIVSYTFMGGYLAVCWTDFFQGLMMALSLFITAlslFFLFSAPEQGVS--YSQIMSEISLESLKPSN------ 231
Cdd:cd10329 150 SIIVLLVITAIYTIAGGLKAVIYTDTLQAVILIIGSAILM---FLAFNEVGGGWSayMAAIPSGTAFHLFRPPDdpdlpw 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 232 -GWFLGLLSLSGWcigYLGQPHVLV-RFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLgSYYFEPKL---------- 299
Cdd:cd10329 227 pGLLLGYPILGIW---YWCTDQVIVqRVLAAKNLKHARRGALFAGYLKLLPLFLMVLPGMI-ARALFPDLvacvvpcgng 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 300 -DNAETVFIALAQAFYHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTyLRKNASDKEVLLVARLGVIAVALIG 378
Cdd:cd10329 303 vGCSDIAYPTLVTELLPVGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIYKR-LRPEASEKELVRVGRIATLVVVVIS 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 379 LALA------FNKADQTLLSMVAFAWGGFGAAFgpviLLSLFWPAMTKAAAIFGMITGAAIALVWEILDGGIFD------ 446
Cdd:cd10329 382 ILWApiiqaqGGSLFNYIQSVLSYLAPPIAAVF----LLGIFWKRTNEQGAFWGLIAGLVLGLVRLILEFAYGEpdtrpa 457
|
490 500
....*....|....*....|.
gi 520914081 447 IFGVVPGFLMSTLVIVVSTLL 467
Cdd:cd10329 458 IIGGIHFLYFAFLLFVVSVIV 478
|
|
| SLC5sbd_NIS-like_u1 |
cd11493 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
8-436 |
4.75e-26 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271384 [Multi-domain] Cd Length: 479 Bit Score: 110.38 E-value: 4.75e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 8 FILYLLGMLAIGYYFYRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFTLMG-VYLN 86
Cdd:cd11493 5 IVLYLLGLPLLGLWLSGRQKSTADYFLGGRSMPWWAVCLSVVATETSTLTFLSIPGLAYGGDLTFLQLALGYILGrIIVA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 87 WKLIAPRLRLETEklndaqTIPEYLHNRFKDNTNVLQLTSSLVTLLFFT---LYvAAGLSGGAVLFESTFGLSYESALII 163
Cdd:cd11493 85 FVLLPRYFRGEVV------SAYELLGQRFGGGMQKTASVTFLVTRLLADgvrLF-AAAIPVSMILGADGVALSYIASILI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 164 GSIVIVSYTFMGGYLAVCWTDFFQglmMALSLFITALSLFFLFSApeQGVSYSQIMSEISLESLKPSNGWFLGLLS---- 239
Cdd:cd11493 158 ISVVTLLYTYFGGIRAVVWTDVIQ---LVVYIGGAVAALAYLLGA--LPADWLQIAAAAGKFHLFDLSDLILGLTSpytf 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 240 ---LSGWCIGYL---GQPHVLV-RFMSVRSVEDVkvsrRIAMVWSTITMMSAV----VVGVLGSYYFE------PKLDNA 302
Cdd:cd11493 233 waaIIGGALLSMashGTDQLMVqRLLACRNLRDA----QKALIGSGVVVFPQFalflLIGLLLYVYYGgaslaaLGLGSP 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 303 ETVFIALAQAFYHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVI--AVALIGLA 380
Cdd:cd11493 309 DEVFPYFIVHELPAGLRGLLIAGILAAAMSTLSSALNSLASSTVQDLYQPWKRRRLSDEKLLRASRLLTLvwAVVLVGIA 388
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 381 LAFNKADQTL----LSMVAFAWGGFGAAFgpviLLSLFWPAMTKAAAIFGMITGAAIALV 436
Cdd:cd11493 389 LLFQYTDQPVvelgLSIASFTYGGLLGVF----LLGLLTRRASQRDAIAAFIVGFLVMLL 444
|
|
| SLC5sbd_NIS-SMVT |
cd11492 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
5-435 |
1.73e-24 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271383 [Multi-domain] Cd Length: 522 Bit Score: 106.42 E-value: 1.73e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 5 YTAFILYLLGMLAIGYYF---YRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFTLM 81
Cdd:cd11492 3 YVVFVAMLLISAAIGIYFgffGGKQKTTEEYLLGGRNMSVFPVALSLIASFISGITLLGTPAEIYYYGTQYWLIVIAYVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 82 GVYLNWKLIAP---RLRLeteklndaQTIPEYLHNRFkdNTNVLQLTSSLVTLLFFtLYVAAGLSGGAVLFESTFGLSYE 158
Cdd:cd11492 83 VGPITAYIFLPvfyNLQL--------TSVYEYLELRF--NRRVRLLASFLFILQML-LYLPIVIYAPALALSQVTGINLH 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 159 SALIIGSIVIVSYTFMGGYLAVCWTDFFQGLMMALSLFITALslfflfsapeQGVSY----SQIMsEISLES-------- 226
Cdd:cd11492 152 IIILVVGIVCIFYTTLGGLKAVVWTDVFQVVVMFGGVLAVII----------LGTIDvggfSEVW-EIAEEGgrleffnf 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 227 -LKPS--NGWFLGLLSLSGWCIGYLG-QPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVG-VLGSYYFEP---- 297
Cdd:cd11492 221 dPDPTvrHTFWSLVIGGTFTWLSLYGvNQTQVQRYLSLPSLKSAKKALWLNIVGLILILSLCCFTGlVIYAKYHDCdplt 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 298 --KLDNAETVFIALA-QAFYH-PLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIA 373
Cdd:cd11492 301 agLIKKPDQLLPYFVmDVLGHlPGLPGLFVAGIFSAALSTLSSGLNSLAAVILEDFIKPFFKKKLSERQATNIMKLLVVV 380
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 520914081 374 VALIGLALAFnkADQTLLSMVAFAWGGFGAAFGPVI---LLSLFWPAMTKAAAIFGMITGAAIAL 435
Cdd:cd11492 381 FGLLCIGLAF--LVEKLGGVLQLSLSIFGITGGPLLgifTLGMFFPWANSKGALVGLLVGLIFML 443
|
|
| SLC5sbd_NIS-like_u2 |
cd11494 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
5-468 |
2.71e-23 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271385 [Multi-domain] Cd Length: 473 Bit Score: 102.29 E-value: 2.71e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 5 YTAFILYLLGMLAIGYYFYRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSV----------W 74
Cdd:cd11494 3 WIVLVGYLLGILVYGVYKGRGQKNQEDYFLGGRSMPWWPIGLSIMATQASAITFLSAPGQAYSDGMRFVqyyfglplamI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 75 IIVFTLMGVYLNWKLIaprlrleteklndaqTIPEYLHNRFKDNTNVlqltssLVTLLFFtlyVAAGLSGGAVLF----- 149
Cdd:cd11494 83 FLCITFVPVFYKLKVY---------------TAYEYLERRFGLKTRL------LTSILFL---ISRGLATGVTIYapaii 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 150 -ESTFGLS-YESALIIGSIVIVsYTFMGGYLAVCWTDFFQGLMMALSLFITALSLFFLFSAPEQGVSYSQIMSEiSLESL 227
Cdd:cd11494 139 lSTILGWSlWLTILLIGGITII-YTVLGGIKAVIWTDVIQMVIIWAGLFIAFGLLLKLLPVGFVDALLVAGKSG-RLNAL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 228 KPSNGWFL------GLLSLSGWCIGYLGQPHVLV-RFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVL-GSYY----- 294
Cdd:cd11494 217 DFSFDLSDtytfwsGLIGGFFLYLSYFGTDQSQVqRYLTAKSIKEARKSLLLNGFLKFPMQFFILLIGVLvFVFYqfnpf 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 295 ------FEPKLDNAETVFIALAQAFYHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVAR 368
Cdd:cd11494 297 pvsfnpAEDETKDTNYIFLRFVLNYLPPGVIGLLIAAIFAAAMSSIDSALNSLATVTVIDIYRRFFKKDASDEHYLKVSR 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 369 LG--VIAVALIGLALAFNKADqTLLSMVafawGGFGAAF-GP---VILLSLFWPAMTKAAAIFGMITG-AAIALVWEILD 441
Cdd:cd11494 377 LLtvFWGLLAIVFALFAGLAG-SLIEAV----NKLGSLFyGPilgVFLLAFFTKKANGKGVFAGAILGvIVVIVLWLFPD 451
|
490 500
....*....|....*....|....*..
gi 520914081 442 ggIFDIFGVVPGFLmstLVIVVSTLLS 468
Cdd:cd11494 452 --VSWLWWNVIGCV---VVIGVALLLS 473
|
|
| SLC5sbd_NIS-like |
cd10326 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
8-394 |
9.20e-22 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271361 [Multi-domain] Cd Length: 472 Bit Score: 97.63 E-value: 9.20e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 8 FILYLLGMLAIGYYFYRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLgSVWIIVFTLMGVYLnw 87
Cdd:cd10326 5 VVVYFLILLAISYYTSRRNADNDDFFLGNRQSPWYLVAFSMIGTSLSGVTFVSVPGEVGGSGF-TYLQMVLGFLLGYL-- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 88 kLIA----PRLRleteKLNdAQTIPEYLHNRFKDNTnvlQLTSSLVTLLF------FTLYVAAgLSGGAVLFESTFGLSY 157
Cdd:cd10326 82 -IIAfvllPLYY----RLN-LTSIYEYLEDRFGVSS---RKTGAVFFLLSrilgagIRLYLVA-LVLQQFLFDSLGIPFW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 158 ESALIIGSIVIVsYTFMGGYLAVCWTDFFQGLMMALSLFITalslfFLFSAPEQGVSYSQIMSEISLESLKPSNGWFLG- 236
Cdd:cd10326 152 LTVLITGLLIWL-YTFRGGIKTVVWTDTLQTVFLLVGLVLT-----IIIISNSLGLGFGEAISAAGESGYSRIFNFDDDn 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 237 --------LLSLSGWCIGYLGQPHVLV-RFMSVRSVEDVkvsrRIAMVWSTITMMSAV----VVGVLGSYYFE-----PK 298
Cdd:cd10326 226 srrtfwkqFLGGIFITIAMTGLDQDMMqRNLSCKNLKDA----QKNMLTFGVILVPVNllflLLGVLLYTYAQkngiaLP 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 299 LDNAETVFIALAQAFYHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIAVALIG 378
Cdd:cd10326 302 AKDSDQLFPYFALNGLPPGVSGLFVAGIIAAAMSSADSALTALTTSFCVDILNRFKRKSEKKSERKYVHIAFSLTFVLGI 381
|
410
....*....|....*.
gi 520914081 379 LALAFNKADQTLLSMV 394
Cdd:cd10326 382 LVFGSASNSGSLIDAI 397
|
|
| PRK12488 |
PRK12488 |
cation/acetate symporter; |
8-440 |
1.26e-20 |
|
cation/acetate symporter;
Pssm-ID: 237114 [Multi-domain] Cd Length: 549 Bit Score: 94.87 E-value: 1.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 8 FILYLLGMLAIGYYFYRKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVwiivFTLMGVYLNW 87
Cdd:PRK12488 38 FMVFVLFTLGITRWAARRTRSASDFYTAGGGLTGMQNGLAIAGDMISAASFLGISAMMFMNGYDGL----LYALGVLAGW 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 88 KLIaprLRLETEKLNDAQTIPEYLHNRFKDNTNVLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESALIIGSIV 167
Cdd:PRK12488 114 PII---LFLIAERLRNLGKYTFADVVSYRLAQGPVRLTAAFGTLTVVLMYLVAQMVGAGKLIELLFGISYLYAVVIVGAL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 168 IVSYTFMGGYLAVCWTDFFQGLMMALSL-FITALSLFFLFSAPEQGVSYSQIMSEISLESLKP----SNGwfLGLLSLS- 241
Cdd:PRK12488 191 MVLYVTFGGMLATTWVQIIKAVLLLSGTsFMAFMVLKHFGFSTEAMFASAVAVHAKGQAILAPggllSNP--IDAISLGl 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 242 GWCIGYLGQPHVLVRFMSVRSVEDVKVSRRIA--------MVWSTITMMSAVVVGVLGSYYFEPK--LDNAETVFIALAQ 311
Cdd:PRK12488 269 GMMFGTAGLPHILMRFFTVSDAREARKSVLYAtgfigyfyLLIIVVGFGAIVMVGTEPSYRDAGGkiIGGGNMVAVHLAQ 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 312 AFYHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRK-NASDKEVLLVARLGVIAVALIGLALAFNKADQTL 390
Cdd:PRK12488 349 AVGGNLFLGFISAVAFATILAVVAGLALSGASAVSHDLYACVIRKgQASEAQEMRVSKIATLGIGLLAVVLGLMFESQNI 428
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 520914081 391 LSMVAFAWGGFGAAFGPVILLSLFWPAMTKAAAIFGMITGAAIALVWEIL 440
Cdd:PRK12488 429 AFLSGLVLAIAASVNFPVLFLSMFWKGLTTRGAVAGSYAGLVSAVVLVVL 478
|
|
| SLC5sbd_vSGLT |
cd10325 |
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ... |
8-475 |
4.30e-17 |
|
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271360 Cd Length: 523 Bit Score: 83.89 E-value: 4.30e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 8 FILYLLGMLAIGYYFYR----KTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSV---WIIVFTL 80
Cdd:cd10325 3 FIVYVILIIGLGLWVSRekkgGEKDATDYFLAGKSLPWWAIGASLIAANISAEQFIGMSGSGFAIGLAIAsyeWMAAITL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 81 mgVYLNWKLIAPRLRleteklNDAQTIPEYLHNRFKDNTNVLQLTSSLVTLLFFTLyvAAGLSGGAVLFESTFGLSYESA 160
Cdd:cd10325 83 --IIVAKFFLPIFLK------NGIYTMPQFLEERYDGRVRTIMAVFWLLLYVFVNL--TSVLYLGALAIETITGIPLTYS 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 161 LIIGSIVIVSYTFMGGYLAVCWTDFFQGLMMALS-LFITALSLFFLFSAPEQGVSYSQIMSEIS------LESLKPSNGW 233
Cdd:cd10325 153 IIGLALFAAAYSIYGGLKAVAWTDVIQVVFLVLGgLVTTYIALSLLGGGEGVFAGFTLLAAEAPehfhmiLDKSNPEDAY 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 234 --FLGLLSLSG--WC--IGYLG-QPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSYYFEPKLDNAETVF 306
Cdd:cd10325 233 kdLPGIAVLLGglWVanLSYWGfNQYIIQRALAAKSLSEAQKGIVFAAFLKLLIPFIVVIPGIAAYVLASNLLLPAATGI 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 307 IALAQAF------YHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIAVALIGLA 380
Cdd:cd10325 313 EKPDQAYpwllrnLPTGLKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKKYIPKKASEKQLVNVGRLAAVIALIIAAL 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 381 LA-----FNKADQTLLSMVAFAWGGFGAAFgpviLLSLFWPAMTKAAAIFGMITGAAIALVWEILDGGI--FDIFGVVpg 453
Cdd:cd10325 393 IAppllgLDQAFQYIQEYTGFISPGILAIF----LLGLFWKRATSAGALVAAILSIVLSALFKFLLPELpfLDRMGYV-- 466
|
490 500
....*....|....*....|..
gi 520914081 454 FLMSTLVIVVSTLLSAKNDGKE 475
Cdd:cd10325 467 FFICVVLIVLVSLLTPKGKDDP 488
|
|
| PRK10484 |
PRK10484 |
putative transporter; Provisional |
8-430 |
8.38e-16 |
|
putative transporter; Provisional
Pssm-ID: 236699 [Multi-domain] Cd Length: 523 Bit Score: 79.54 E-value: 8.38e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 8 FILYLLGMLAIGYYFYRKTNTVSD--YILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSV-W----IIVFTL 80
Cdd:PRK10484 7 FLGFTLLVAVISWWKTRKTDTSSSdgYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGMSVMaWevtaAIALII 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 81 MGVYLnwkliAPR-LRleteklNDAQTIPEYLHNRFKDNT----NVLQLTSSLVTLLFFTLYvaaglsGGAVLFES---- 151
Cdd:PRK10484 87 LALIF-----LPRyLK------SGITTIPDFLEERYDKTTrrivSILFLIGYVVSFLPIVLY------SGALALNSlfhv 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 152 --TFGLSYESALIIGSIVI----VSYTFMGGYLAVCWTDFFQGL-MMALSLFITALSLFFLfsapeQGVSYSQIMSEIS- 223
Cdd:PRK10484 150 seLLGISYGAAIWLLVWLIgiigAIYAVFGGLKAVAVSDTINGIgLLIGGLLVPVFGLIAL-----GDGSFMQGLEQLTt 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 224 -----LESLKPSNG---W---FLGLL--SLSGWCIgylgQPHVLVRFMSVRSVedvKVSRRIAMVWSTITMMSAVVV--- 287
Cdd:PRK10484 225 vhpekLNSIGGATDpvpFptlFTGLIlvNLFYWCT----NQSIVQRALGAKNL---AEGQKGALLAAFFKLLGPLILvlp 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 288 GVLGSYYFEPKLDNAETVFIALAQAFYHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVA 367
Cdd:PRK10484 298 GIIAFHLYGDGLPNADMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYKPIINPNASEKQLVKVG 377
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 520914081 368 RLGVIAVALIGLALA--FNKADQTLLSMVAFAWGGFGAAFGPVILLSLFWPAMTKAAAIFGMITG 430
Cdd:PRK10484 378 KKFGFVLAIISMIVAplIANAPQGLYSYLQQLNGIYNVPILAIIIVGFFTKRVPALAAKVALGFG 442
|
|
| actP |
PRK09395 |
cation/acetate symporter ActP; |
8-449 |
2.33e-15 |
|
cation/acetate symporter ActP;
Pssm-ID: 236495 Cd Length: 551 Bit Score: 78.48 E-value: 2.33e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 8 FILYLLGMLAIGYYFYRKTNTVSDY------ILGSRNLPPSVAALSSGASDLSGWALM---GLPGALYAGGLGSVW-IIV 77
Cdd:PRK09395 40 FLIFVVFTLGITYWAAKRTRSASDFytagggITGFQNGLAIAGDYMSAASFLGISALVftsGYDGLIYSIGFLVGWpIIL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 78 FtlmgvylnwkLIAPRLRleteklNDAQ-TIPEYLHNRFKDN-TNVLQLTSSLVTLLFftlYVAAGLSGGAVLFESTFGL 155
Cdd:PRK09395 120 F----------LIAERLR------NLGKyTFADVASYRLKQGpIRTLSACGSLVVVAL---YLIAQMVGAGKLIQLLFGL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 156 SYESALIIGSIVIVSYTFMGGYLAVCWTDFFQG--------LMMALSLFITALSLFFLFS-APEQGVSYSQIMSEISLES 226
Cdd:PRK09395 181 NYHVAVVLVGVLMMVYVLFGGMLATTWVQIIKAvlllsgatFMAFMVMKHVGFSFENLFSeAVAVHPKGLAIMGPGGLVK 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 227 lKPSNGWFLGLlslsGWCIGYLGQPHVLVRFMSVRSVEDVKVSRRIAMVW-------STITMMSAVVVGVLGSYYFEPK- 298
Cdd:PRK09395 261 -DPISALSLGL----ALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFigyfyilTFIIGFGAIVLVGTNPEFKDAAg 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 299 --LDNAETVFIALAQAFYHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRK-NASDKEVLLVARLGVIAVA 375
Cdd:PRK09395 336 alIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIKKgKATERDELRVSKITTLVLG 415
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 520914081 376 L--IGLALAFNKadQTLLSMVAFAWGGFGAAFGPVILLSLFWPAMTKAAAIFGMITGAAIALVWEILDGGIF-DIFG 449
Cdd:PRK09395 416 VvaIILGILFEK--QNIAFMVGLAFAIAASANFPVLLLSMYWKGLTTRGAVIGGWLGLISAVVLMILSPTVWvDILG 490
|
|
| SLC5sbd_SGLT1 |
cd11486 |
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ... |
6-435 |
3.92e-15 |
|
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.
Pssm-ID: 271379 Cd Length: 636 Bit Score: 78.05 E-value: 3.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 6 TAFILYLLGMLAIGYYFYRKTN--TVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGL---GSVW-IIVFT 79
Cdd:cd11486 4 SVIVIYFVVVLAVGVWAMVSTNrgTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIaigGFEWnALVVV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 80 lmgVYLNWKLIAPRLRLeteklnDAQTIPEYLHNRFKDNTnvLQLTSSLVTLLFFTLY-VAAGLSGGAVLFESTFGLSYE 158
Cdd:cd11486 84 ---VVLGWLFVPIYIKA------GVVTMPEYLRKRFGGQR--IQVYLSVLSLCLYIFTkISADIFSGAIFINLALGLNLY 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 159 SALIIGSIVIVSYTFMGGYLAVCWTDFFQGLMMALSLFITALSLF--------FL---FSAPEQGVSYSQIMSEISLESL 227
Cdd:cd11486 153 LAIVILLAITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFnevggydaFMekyMTAIPSVIGTGNSTSQEKCYTP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 228 K---------------PSNGWFLGLLSLSGWcigYLGQPHVLV-RFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLG 291
Cdd:cd11486 233 RadsfhifrdpitgdlPWPGLLFGLSILTLW---YWCTDQVIVqRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGMIS 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 292 SYYFEPKL-----DNAETVF---IALAQAFYHPLVA--------GLIIAGVLAAIMSTIDSQLLVCSTTISEDLYkTYLR 355
Cdd:cd11486 310 RILYTDEIacvvpDECKAVCgteVGCTNIAYPKLVVelmpnglrGLMLSVMLASLMSSLTSIFNSASTLFTMDIY-TKVR 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 356 KNASDKEVLLVARLgvIAVALIGLALAFNKADQTLLSMVAFAW-----GGFGAAFGPVILLSLFWPAMTKAAAIFGMITG 430
Cdd:cd11486 389 KKASEKELMIAGRL--FMLVLIGISIAWVPIVQSAQSGQLFDYiqsitSYLGPPIAAVFLLAIFCKRVNEPGAFWGLCVG 466
|
....*
gi 520914081 431 AAIAL 435
Cdd:cd11486 467 LLVGL 471
|
|
| SLC5sbd_SGLT5 |
cd11489 |
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ... |
27-441 |
4.91e-15 |
|
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212058 Cd Length: 604 Bit Score: 77.67 E-value: 4.91e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 27 NTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGL---GSVWIIVFTLMGvyLNWKLIAPRLRLETeklnd 103
Cdd:cd11489 29 NTVSGYFLAGRDMAWWPIGASLFASSEGSGLFIGLAGTGAAGGIavaGFEWNATYALLA--LAWVFVPVYISSGI----- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 104 aQTIPEYLHNRFKDNTNVLQLTSSLVTLLFFTlYVAAGLSGGAVLFESTFGLSYESALIIGSIVIVSYTFMGGYLAVCWT 183
Cdd:cd11489 102 -VTMPEYLQRRFGGERIRMYLSVLSLLLSVFT-KISTDLYSGALFVQVCLGWNLYLSTVLMLVVTALYTIAGGLAAVIYT 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 184 DFFQGLMMALSLFITALSLF-------FLFSAPEQGVSySQIMSEISLESLK---------------PSNGWFLGLLSLS 241
Cdd:cd11489 180 DALQTLIMVIGAVILTIKAFnqiggysNLEEAYLQAVP-SKIIPNTTCHLPRadamhlfrdpvtgdlPWTGMTFGLTIMA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 242 GWcigYLGQPHVLV-RFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSYYFEPKL---DNAETVFIALAQA----- 312
Cdd:cd11489 259 TW---YWCTDQVIVqRSLSARSLSHAKGGSILASYLKMLPMGLIIMPGMISRALFPDDVacvDPEECLRVCGAEVgcsni 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 313 FYHPLVA--------GLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYlRKNASDKEVLLVARLgvIAVALIGLALAFN 384
Cdd:cd11489 336 AYPKLVMelmpsglrGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWRRL-RPGASERELLLVGRL--VTVILVGVSVVWI 412
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 520914081 385 KADQTLLSMVAFAW-----GGFGAAFGPVILLSLFWPAMTKAAAIFGMITGAAIALVWEILD 441
Cdd:cd11489 413 PILQSSNSGQLYIYiqsvtSYLAPPVTAVFVLAVFWRRANEQGAFWGLMAGLVVGLTRMVLE 474
|
|
| SLC5sbd_YidK |
cd10328 |
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ... |
11-430 |
8.92e-15 |
|
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271362 Cd Length: 472 Bit Score: 76.42 E-value: 8.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 11 YLLGMLAIGYYFYRKT-----NTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFTLMGVYL 85
Cdd:cd10328 1 FLLFTALVALISWYKTrgddlSSSDGYFLAGRSLTGVVIAGSLLLTNLSTEQLVGLNGQAYALGMSVMAWEVTAAIALII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 86 NWKLIAPR-LRleteklNDAQTIPEYLHNRFKDNT----NVLQLTSSLVTLLFFTLYvaaglsGGAVLFES------TFG 154
Cdd:cd10328 81 LALVFLPRyLK------GGITTIPEFLEERYDETTrrivSILFLLGYVVILLPIVLY------SGALALNSlfdvseLLG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 155 LSYESALIIGSIVI----VSYTFMGGYLAVCWTDFFQG-LMMALSLFITALSLFFLFSA-PEQGVSYsqIMSEI------ 222
Cdd:cd10328 149 ISYFQALWLLVWLIgiigAIYAIFGGLKAVAVSDTINGvGLLIGGLLIPILGLIALGDGsFLAGLDT--LLTAHpeklna 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 223 --SLESLKPSNGWFLGLL--SLSGWCIG-YLGQphvlvRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSYYFEP 297
Cdd:cd10328 227 igGADSPVPFSTLFTGMLlvNLFYWCTNqAIIQ-----RALAAKNLKEGQKGVLLAGFFKLLVPLILVLPGIIAFHLYGD 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 298 KLDNAETVFIALAQAFYHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRKNASDKEVLLVARLGVIAVALI 377
Cdd:cd10328 302 GLENADMAYPTLVADVLPKWLSGFFAAVLFGAILSSFNSALNSAATLFSLDIYKPIINKNATDKQLVKVGKIFGIVLALI 381
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 520914081 378 GLALA--FNKADQTLLSMVAFAWGGFGAAFGPVILLSLFWPAMTKAAAIFGMITG 430
Cdd:cd10328 382 SMIIApfIAYAPEGLFNYLQQFNGFFSIPILAIVLVGFFTKRVPALAAKIALIFG 436
|
|
| SLC5sbd_SGLT2 |
cd11487 |
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ... |
9-435 |
1.06e-13 |
|
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212056 [Multi-domain] Cd Length: 583 Bit Score: 73.42 E-value: 1.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 9 ILYLLGMLAIGYYFYRKTN--TVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGL---GSVWIIVFTLMgv 83
Cdd:cd11487 7 AAYFLLVIGVGLWSMCRTNrgTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGIavaGFEWNALFVVL-- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 84 YLNWKLIAPRLRLETeklndaQTIPEYLHNRFKDNTNVLQLTSSLVTLLFFTlYVAAGLSGGAVLFESTFGLSYESALII 163
Cdd:cd11487 85 LLGWLFVPVYLTAGV------ITMPQYLKKRFGGQRIRLYLSVLSLFLYIFT-KISVDMFSGAVFIQQALGWNIYASVIA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 164 GSIVIVSYTFMGGYLAVCWTDFFQGLMMALSLFI------------TALSLFFLFSAPEQGVSYSQIMSEISLESLKPSN 231
Cdd:cd11487 158 LLGITMIYTVTGGLAALMYTDTVQTFVIIGGACVlmgyafhevggySALFEKYLKAVPSLTVSEDPAVGNISSSCYRPRP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 232 -----------------GWFLGLLSLSGWcigYLGQPHVLV-RFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSY 293
Cdd:cd11487 238 dsyhllrdpvtgdlpwpALILGLTIVSSW---YWCSDQVIVqRCLAARSLTHVKAGCILCGYLKLLPMFLMVMPGMISRV 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 294 YF-------EPKLDNAET-VFIALAQAFYHPLVA--------GLIIAGVLAAIMSTIDSQLLVCSTTISEDLYkTYLRKN 357
Cdd:cd11487 315 LYpdevacvEPSVCLRVCgTEVGCSNIAYPKLVVklmpnglrGLMLAVMLAALMSSLASIFNSSSTLFTMDIW-TRLRPQ 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 358 ASDKEVLLVARLGVIAVALIGLA-LAFNKADQT--LLSMVAFAWGGFGAAFGPVILLSLFWPAMTKAAAIFGMITGAAIA 434
Cdd:cd11487 394 AGDKELLLVGRVWVVCIVAVSVAwIPVVQAAQGgqLFDYIQSVSSYLAPPIAAVFFLALFVKRVNEPGAFWGLIGGLLMG 473
|
.
gi 520914081 435 L 435
Cdd:cd11487 474 L 474
|
|
| SLC5sbd_SGLT4 |
cd11488 |
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ... |
9-441 |
9.67e-13 |
|
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.
Pssm-ID: 271380 Cd Length: 605 Bit Score: 70.35 E-value: 9.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 9 ILYLLGMLAIGYYFYRKTN--TVSDYILGSRNLP--PSVAALSSgaSDLSGWALMGLPGALYAGGL---GSVWIIVFTLM 81
Cdd:cd11488 6 VVYFVFVLAVGIWSSIRASrgTVGGYFLAGRSMTwwPIGASLMS--SNVGSGLFIGLAGTGAAGGLavgGFEWNAAWVLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 82 GvyLNWKLIAPRLRleteklNDAQTIPEYLHNRFKDNTnvLQLTSSLVTLLFFTLY-VAAGLSGGAVLFESTFGLSYESA 160
Cdd:cd11488 84 A--LGWIFVPVYIA------AGVVTMPEYLKKRFGGQR--IRIYMSVLSLILYIFTkISTDIFSGALFIQVSLGWNLYLS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 161 LIIGSIVIVSYTFMGGYLAVCWTDFFQGLMMALSLFITalsLFFLFSA----PEQGVSYSQIMSEISLESLK-------- 228
Cdd:cd11488 154 TVILLAVTALYTIAGGLTAVIYTDALQTVIMVIGAFVL---MFIAFDKvgwyPGLEQQYEKAIPALTVPNTTchlprsda 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 229 ------------PSNGWFLGLLSLSGWCigYLGQPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSYYFE 296
Cdd:cd11488 231 fhifrdpvtgdiPWPGLIFGLTVLATWV--WCTDQVIVQRSLSAKNLSHAKGGSVLGGYLKILPMFFVVMPGMISRALFP 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 297 PK---LDNAETVFIALAQA-----FYHPLVA--------GLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTyLRKNASD 360
Cdd:cd11488 309 DEvgcVDPDECQKICGAKVgcsniAYPKLVVelmpvglrGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQR-IRRRASE 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 361 KEVLLVARlgVIAVALIGLALAFNKADQTLLSMVAFAWGGFGAAF-----GPVILLSLFWPAMTKAAAIFGMITGAAIAL 435
Cdd:cd11488 388 QELMVVGR--VFILLLVVISILWIPIIQTANSGQLFDYIQAVTSYlsppiTAVFILAIFWKRVNEPGAFWGLMVGLVVGL 465
|
....*.
gi 520914081 436 VWEILD 441
Cdd:cd11488 466 VRMIME 471
|
|
| SLC5sbd_SMVT |
cd11504 |
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This ... |
5-435 |
8.72e-12 |
|
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This multivitamin transporter SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate, and is essential for mediating biotin uptake into mammalian cells. SMVT is expressed in the placenta, intestine, heart, brain, lung, liver, kidney and pancreas. Biotin may regulate its own cellular uptake through participation in holocarboxylase synthetase-dependent chromatin remodeling events at SMVT promoter loci. The cis regulatory elements, Kruppel-like factor 4 and activator protein-2, regulate the activity of the human SMVT promoter in the intestine. Glycosylation of the hSMVT is important for its transport function. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271394 [Multi-domain] Cd Length: 527 Bit Score: 67.21 E-value: 8.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 5 YTAFILYLLGMLAIGYYFY---RKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFTLM 81
Cdd:cd11504 6 YVVFSLLLVISAGIGLYYActgGKQKTTREFLMADRKMGCLPVALSLLATFQSAVAILGGPSESYTFGTQYWFLGCSYFL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 82 GVYLNWKLIAP---RLRLETEKlndaqtipEYLHNRFKDNTNVLqltsSLVTLLF-FTLYVAAGLSGGAVLFESTFGLSY 157
Cdd:cd11504 86 GLLIPAHVFIPvfyRLELTSAY--------EYLELRFNKTVRIC----GTVTFIFqMVIYMGVVLYAPALALNAVTGFNL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 158 ESALIIGSIVIVSYTFMGGYLAVCWTDFFQGLMMalslFITALSLFFLFSAPEQGVS----YSQIMSEISLESLKPSNgw 233
Cdd:cd11504 154 WISVLAMGVVCTFYTALGGLKAVIWTDVFQTVVM----FAGQLAVIIVGSIEAGGIArvwrVAAESDRIDGFNLSPDP-- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 234 flgLLSLSGWCIGYLGQPHVLV----------RFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVG-VLGSYYFE-PKLDN 301
Cdd:cd11504 228 ---TIRHTFWTLVVGGVFNMLAlygvnqaqvqRYLSSRTEKQAKRSCYLVFPGQQLSLCIGCLCGlVMFARYHEcDPLKN 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 302 AET-------VFIALAQAFYHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYlRKNASDKEVLLVARlgVIAV 374
Cdd:cd11504 305 GIVarsdqlvPYFVMDVLDGLPGLPGLFIACLFSGALSTISSAFNSLATVTMEDLIVPK-FPDMTEERATLLSK--GLAV 381
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 520914081 375 ALIGLALAFNKADQTLLSMVAFAWGGFGAAFGPVI---LLSLFWPAMTKAAAIFGMITGAAIAL 435
Cdd:cd11504 382 GYGLLCLLMAYLASTMGQVLQAANSIFGMIGGPLLglfCLGMFFPCANSAGAVVGLLAGLFMAF 445
|
|
| SLC5sbd_SMIT |
cd11491 |
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ... |
9-441 |
2.85e-11 |
|
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271382 Cd Length: 609 Bit Score: 65.66 E-value: 2.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 9 ILYLLGMLAIGYYFYRKTN--TVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLG-SVWIIVFTLMGVYL 85
Cdd:cd11491 6 ALYFILVMCIGIYAMWKSNrsTVSGYFLAGRSMTWLPVGASLFASNIGSEHFIGLAGSGAAAGFAvGAFEFNALILLQLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 86 NWkliaprLRLETEKLNDAQTIPEYLHNRFKDNTNVLQLtSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESALIIGS 165
Cdd:cd11491 86 GW------VFIPVYIRSGVYTLPEYLSKRFGGHRIQVYL-AALSLILYIFTKISVNLYSGALFIQEALGWNLYVSIILLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 166 IVIVSYTFMGGYLAVCWTDFFQGLMM---ALSLFITA----------LSLFFLFSAPEQGVSYSQIMSEISL-------E 225
Cdd:cd11491 159 GLTALLTVTGGLAAVIYTDTLQAFLMiigALTLMIISmmeiggfegvKSRYMLASPNVTSILLTYNLSNTNSccvhpkkD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 226 SLK----------PSNGWFLGLLSLSGWcigYLGQPHVLV-RFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSYY 294
Cdd:cd11491 239 AFKllrdptdedvPWPGFILGQTPASIW---YWCADQVIVqRVLAAKSLSHAQGATLMAGFIKLLPLFIIVIPGMISRIL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 295 FEPKL--DNAETVFIALAQAF------YHPLVA--------GLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTyLRKNA 358
Cdd:cd11491 316 FPDDIacINPEHCMQVCGSRAgcsniaYPRLVMkimpsglrGLMMAVMIAALMSDLTSIFNSASTLFTLDVYKL-IRKKA 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 359 SDKEVLLVARLGVIAVALIGLA---LAFNKADQTLLSMVAFAWGGFGAAFGPVILLSLFWPAMTKAAAIFGMITGAAIAL 435
Cdd:cd11491 395 SSRELMIVGRIFVAVMVVISIAwipVIQEMQGGQLYLYIQEVAAYLTPPVASLYLLAIFWKRTTEQGAFYGGMAGFVLGA 474
|
....*.
gi 520914081 436 VWEILD 441
Cdd:cd11491 475 VRLILA 480
|
|
| SLC5sbd_SMCT |
cd11505 |
Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; ... |
5-435 |
2.61e-09 |
|
Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. It also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and, through transporting L-lactate and ketone bodies, helps maintain the energy status and the function of neurons. SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. hSMCT2 is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, SMCT2 may initiate lactate absorption in the early parts of the tubule, SMCT1 in the latter parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271395 Cd Length: 538 Bit Score: 59.52 E-value: 2.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 5 YTAFILYLLGMLAIGYYFY---RKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAggLGSVWIIVFTlm 81
Cdd:cd11505 9 YVVFAAMLFISAGIGIYYAfagGGQATSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPSEVYR--FGASFLIFAF-- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 82 gVYLNWKLIAPRLRLETEKLNDAQTIPEYLHNRFkdnTNVLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESAL 161
Cdd:cd11505 85 -AYLFVVLISSEVFLPVFYRLGITSTYEYLELRF---NKPVRLAGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 162 IIGSIVIVSYTFMGGYLAVCWTDFFQ-GLMMA--LSLFITALSLFFLFSAPEQGVSYSQIMS--EISLESLKPSNGWFLG 236
Cdd:cd11505 161 VATGVVCTFYCTLGGLKAVVWTDVFQvGIMVAgfLSVIIQAVVHQGGIHNILNDSYNGSRLNfwDFDPNPLRRHTFWTIT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 237 LLSLSGWCIGYLGQPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVG-VLGSYYFEPKLDNAETV--------FI 307
Cdd:cd11505 241 VGGTFTWTGIYGVNQSQVQRYISCKTRFQAKLSLYFNLLGLWAILVCAVFSGlAMYSHYKDCDPWTAKIVsapdqlmpYL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 308 ALAQAFYHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRkNASDKEVLLVAR-----LGVIAVALIGLALA 382
Cdd:cd11505 321 VLDILADYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFR-SLSEKLSSWISKglsllYGAMCIGMAVAASL 399
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 520914081 383 FNKADQTLLSMvafawggFGAAFGPVI---LLSLFWPAMTKAAAIFGMITGAAIAL 435
Cdd:cd11505 400 MGGLLQAALSI-------FGMVGGPLLglfSLGILFPFVNSKGALGGLLTGFAISL 448
|
|
| SLC5sbd_SGLT6 |
cd11490 |
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ... |
8-441 |
7.05e-09 |
|
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271381 Cd Length: 602 Bit Score: 58.00 E-value: 7.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 8 FILYLLGMLAIGYYFYRKT--NTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGsvwIIVFTLMGVYL 85
Cdd:cd11490 5 LVLYFLFVLAVGLWSMWKTkrSTVKGYFLAGKDMTWWPVGASLFASNVGSGHFIGLAGSGAAAGIG---VVAYEWNGLFM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 86 nwKLIAPRLRLETEKLNDAQTIPEYLHNRFKDNTNVLQLTSSLVTLLFFTlYVAAGLSGGAVLFESTFGLSYESALIIGS 165
Cdd:cd11490 82 --VLVLAWLFLPIYIASRVTTMPEYLKKRFGGKRIQIFLAVLYLFIYIFT-KISVDMYAGAVFIQQALQWDLYLAVVGLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 166 IVIVSYTFMGGYLAVCWTDFFQGLMMAL-SLFITALSL-------------FFLFSAPEQGVSYSQIMSEIS-------L 224
Cdd:cd11490 159 GITALYTVAGGLAAVIYTDALQTIIMVIgALILMGYSFaevggfeallekyFQAIPSIRSPNSTCGIPREDAfhifrdpV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 225 ESLKPSNGWFLGLLSLSGWcigYLGQPHVLV-RFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGVLGSYYFEPKLDNAE 303
Cdd:cd11490 239 TSDLPWPGVLLGMSIPSLW---YWCTDQVIVqRSLAAKNLSHAKGGSLLAAYLKVLPLFMMVIPGMISRILFPDQVACAD 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 304 TVF-------------IALAQAFYHPLVA---GLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKtYLRKNASDKEVLLVA 367
Cdd:cd11490 316 PEVckeicgnpsgcsdIAYPKLVMELLPTglrGLMMAVMLAALMSSLTSIFNSASTIFTMDLWR-HIRPRASEWELMIVG 394
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 520914081 368 RLGVIAVALIG-LALAFNKADQ--TLLSMVAFAWGGFGAAFGPVILLSLFWPAMTKAAAIFGMITGAAIALVWEILD 441
Cdd:cd11490 395 RVFVLVLVVVSiLWIPLVQASQggQLFIYIQSISSYLQPPVAVVFIAGCFWKRTNEKGAFWGLMVGLAVGLTRMVLD 471
|
|
| SLC5sbd_SMCT1 |
cd11519 |
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 ... |
5-435 |
3.52e-08 |
|
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. Its expression is under the control of the C/EBP transcription factor. Its tumor-suppressive role is related to uptake of butyrate, propionate, and pyruvate, these latter are inhibitors of histone deacetylases. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. SMCT1 also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and through transporting l-lactate and ketone bodies helps maintain the energy status and the function of neurons. In the kidney its expression is limited to the S3 segment of the proximal convoluted tubule (in contrast to the low-affinity monocarboxylate transporter SMCT2, belonging to a different family, which is expressed along the entire length of the tubule). In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT1 is expressed predominantly in retinal neurons and in retinal pigmented epithelial (RPE) cells. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271402 Cd Length: 542 Bit Score: 55.62 E-value: 3.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 5 YTAFILYLLGMLAIGYYFY---RKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYA-GGLGSVWIIVFTL 80
Cdd:cd11519 9 YVVFAGMLLISAGIGIYYAfagGGQQTSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPAEVYRfGAIFSIFAFTYAI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 81 MgVYLNWKLIAPRLRleteKLNDAQTIpEYLHNRFkdnTNVLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESA 160
Cdd:cd11519 89 V-VVISAEVFLPVFY----RLGITSTY-EYLELRF---NKCVRLIGTSLFIVQTALYTGIVIYAPALALNQVTGFDLWGA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 161 LIIGSIVIVSYTFMGGYLAVCWTDFFQ-GLMMA--LSLFITALSLFFLFSAPEQGVSYSQIMSEISLE--SLKPSNGWFL 235
Cdd:cd11519 160 VVATGVVCTFYCTLGGLKAVIWTDVFQvGIMVAgfVSVIIRAVVLQGGIGTILNDSYYGGRLNFWDFDpnPLQRHTFWTI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 236 GLLSLSGWCIGYLGQPHVLVRFMSVRSVEDVKVSRRIAMVWSTITMMSAVVVGV-LGSYYFEPKLDNAETV--------F 306
Cdd:cd11519 240 VIGGTFTWTSIYGVNQSQVQRYISCKTRFQAKMSLYVNLVGLWAILSCAVLSGLaMYSIYKDCDPWTAKDVsapdqlmpY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 307 IALAQAFYHPLVAGLIIAGVLAAIMSTIDSQLLVCSTTISEDLYKTYLRkNASDKEVLLVAR-----LGVIAVALIGLAL 381
Cdd:cd11519 320 LVLDILADYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFR-SLSERQLSWISMgmsvfYGALCIGMAGLAS 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 520914081 382 AFNKADQTLLSMvafawggFGAAFGPVI---LLSLFWPAMTKAAAIFGMITGAAIAL 435
Cdd:cd11519 399 LMGALLQAALSI-------FGMVGGPLLglfALGILFPFANSIGALVGLMSGFAISL 448
|
|
| SLC5sbd_SMCT2 |
cd11520 |
Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 ... |
5-200 |
9.48e-05 |
|
Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. Human SMCT2 (hSMCT2) is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, it is expressed in the apical membrane of the proximal convoluted tubule, along the entire length of the tubule (in contrast to the high-affinity monocarboxylate transporter SMCT1, belonging to a different family, which is limited to the S3 segment of the tubule). SMCT2 may initiate lactate absorption in the early parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT2 is expressed exclusively in Muller cells. Nicotine transport by hSMCT2 is inhibited by several non-steroidal anti-inflammatory drugs. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212089 [Multi-domain] Cd Length: 529 Bit Score: 44.84 E-value: 9.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 5 YTAFILYLLGMLAIGYYFY---RKTNTVSDYILGSRNLPPSVAALSSGASDLSGWALMGLPGALYAGGLGSVWIIVFTLM 81
Cdd:cd11520 9 YVVFAGLFLVSSGIGVFFAikeRKKATSKEFLVGGRQMSCGPVALSLTASFMSAVTVLGTPAEVYRFGASFVLFFIAYTF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520914081 82 GVYLNWKLIAPRLRLeteklNDAQTIPEYLHNRFkdnTNVLQLTSSLVTLLFFTLYVAAGLSGGAVLFESTFGLSYESAL 161
Cdd:cd11520 89 VIIFTSELFLPVFYR-----SGITSTYEYLELRF---NKPVRYAATLIYIVQTILYTGVVVYAPALALNQVTGFDLWGSV 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 520914081 162 IIGSIVIVSYTFMGGYLAVCWTDFFQGLMMALSlFITAL 200
Cdd:cd11520 161 FATGIVCTFYCTLGGLKAVVWTDAFQMVVMVVG-FLTVL 198
|
|
| |
