NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|521101477|ref|WP_020432350|]
View 

MULTISPECIES: TIGR04211 family SH3 domain-containing protein [Vibrio]

Protein Classification

SH3 domain-containing protein( domain architecture ID 11459669)

Src Homology 3 (SH3) domain-containing protein plays versatile and diverse roles in the cell, including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies, among others

CATH:  2.30.30.40
Gene Ontology:  GO:0005515|GO:0070064
PubMed:  28510178|11256992|1639195
SCOP:  4000369

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK10884 super family cl32601
SH3 domain-containing protein; Provisional
 1-197 8.88e-46

SH3 domain-containing protein; Provisional


The actual alignment was detected with superfamily member PRK10884:

Pssm-ID: 182809 [Multi-domain]  Cd Length: 206  Bit Score: 150.19  E-value: 8.88e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521101477   1 MKKL--ICMVLFSM-LAAPTFAQD-RYIADKLFTYMHSGPSNQYRIIGSIDAGEKVKLINTNKDTDYTQIVDERGRTGWV 76
Cdd:PRK10884   1 MPKLrlIGLTLLALsATAVSHAEEkRYVSDELNTYVRSGPGDQYRIVGTLNAGEEVTLLQVNANTNYAQIRDSKGRTAWI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521101477  77 ESRFVTRDVSMAVRLPQLEKELADVKSKLANARQSADSEKAGLVDSLEVRNKQIAELEKNYSDISKQLTASQSEVRELRA 156
Cdd:PRK10884  81 PLKQLSTTPSLRTRVPDLENQVKTLTDKLNNIDNTWNQRTAEMQQKVAQSDSVINGLKEENQKLKNQLIVAQKKVDAANL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 521101477 157 KLDTQKEDLLLKYFMYGGGVAGGGLLLGLVLPHIIPRRKRN 197
Cdd:PRK10884 161 QLDDKQRTIIMQWFMYGGGVAGIGLLLGLLLPHLIPRRKRK 201
 
Name Accession Description Interval E-value
PRK10884 PRK10884
SH3 domain-containing protein; Provisional
 1-197 8.88e-46

SH3 domain-containing protein; Provisional


Pssm-ID: 182809 [Multi-domain]  Cd Length: 206  Bit Score: 150.19  E-value: 8.88e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521101477   1 MKKL--ICMVLFSM-LAAPTFAQD-RYIADKLFTYMHSGPSNQYRIIGSIDAGEKVKLINTNKDTDYTQIVDERGRTGWV 76
Cdd:PRK10884   1 MPKLrlIGLTLLALsATAVSHAEEkRYVSDELNTYVRSGPGDQYRIVGTLNAGEEVTLLQVNANTNYAQIRDSKGRTAWI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521101477  77 ESRFVTRDVSMAVRLPQLEKELADVKSKLANARQSADSEKAGLVDSLEVRNKQIAELEKNYSDISKQLTASQSEVRELRA 156
Cdd:PRK10884  81 PLKQLSTTPSLRTRVPDLENQVKTLTDKLNNIDNTWNQRTAEMQQKVAQSDSVINGLKEENQKLKNQLIVAQKKVDAANL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 521101477 157 KLDTQKEDLLLKYFMYGGGVAGGGLLLGLVLPHIIPRRKRN 197
Cdd:PRK10884 161 QLDDKQRTIIMQWFMYGGGVAGIGLLLGLLLPHLIPRRKRK 201
SH3_and_anchor TIGR04211
SH3 domain protein; Members of this protein family have a signal peptide, a strongly conserved ...
 23-201 4.33e-42

SH3 domain protein; Members of this protein family have a signal peptide, a strongly conserved SH3 domain, a variable region, and then a C-terminal hydrophobic transmembrane alpha helix region.


Pssm-ID: 275056 [Multi-domain]  Cd Length: 198  Bit Score: 140.53  E-value: 4.33e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521101477   23 YIADKLFTYMHSGPSNQYRIIGSIDAGEKVKLINTNKDTdYTQIVDERGRTGWVESRFVTRDVSMAVRLPQLEKELADVK 102
Cdd:TIGR04211   1 YISDELFVYMRSGPGNQYRILGSLKSGTPVTVLERSEDG-YSRVRTPKGREGWVLSRYLSDTPSARERLPELQQELAELQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521101477  103 SKLANARQSAD---SEKAGLVDSLEVRNKQIAELEKNYSDI-----------------SKQLTASQSEVRELRAKLDTQK 162
Cdd:TIGR04211  80 EELAELQEQLAelrQENQELKQQLSTLEAELEELQKELERIkqisanaieldeenrelREELAELKQENEALEAENERLQ 159

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 521101477  163 EDLLLKYFMYGGGVAGGGLLLGLVLPHIIPRRKRNPAGW 201
Cdd:TIGR04211 160 ENEQRRWFLYGGGVLFLGILLGLILPRLLPRRRRRSDGW 198
YgiM COG3103
Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family ...
 17-93 2.15e-21

Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family [General function prediction only];


Pssm-ID: 442337 [Multi-domain]  Cd Length: 119  Bit Score: 84.79  E-value: 2.15e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521101477  17 TFAQDRYIADKLFTYMHSGPSNQYRIIGSIDAGEKVKLIntNKDTDYTQIVDERGRTGWVESRFVTRDVSMAVRLPQ 93
Cdd:COG3103    1 AAAETRYVVDADALNVRSGPGTSYRIVGTLPKGEKVTVL--GRSGGWYKVRYSNGKTGWVSSRYLTVTPSARERLPD 75
SH3b smart00287
Bacterial SH3 domain homologues;
29-81 6.56e-09

Bacterial SH3 domain homologues;


Pssm-ID: 214600 [Multi-domain]  Cd Length: 63  Bit Score: 50.41  E-value: 6.56e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 521101477    29 FTYMHSGPSNQYRIIGSIDAGEKVKLINTnKDTDYTQIVDERGRTGWVESRFV 81
Cdd:smart00287  10 GLNVRTGPGTSSPIIGTLKKGDKVKVLGV-DGQDWAKITYGSGQRGYVPGYVV 61
SH3_3 pfam08239
Bacterial SH3 domain;
31-82 9.76e-09

Bacterial SH3 domain;


Pssm-ID: 462405 [Multi-domain]  Cd Length: 54  Bit Score: 49.55  E-value: 9.76e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 521101477   31 YMHSGPSNQYRIIGSIDAGEKVKLINTNKDtDYTQIVDERGRTGWVESRFVT 82
Cdd:pfam08239   4 NVRSGPSTSSEVVGTLPKGEKVEVLEEQGG-GWYKVRTYDGYEGWVSSSYLS 54
 
Name Accession Description Interval E-value
PRK10884 PRK10884
SH3 domain-containing protein; Provisional
 1-197 8.88e-46

SH3 domain-containing protein; Provisional


Pssm-ID: 182809 [Multi-domain]  Cd Length: 206  Bit Score: 150.19  E-value: 8.88e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521101477   1 MKKL--ICMVLFSM-LAAPTFAQD-RYIADKLFTYMHSGPSNQYRIIGSIDAGEKVKLINTNKDTDYTQIVDERGRTGWV 76
Cdd:PRK10884   1 MPKLrlIGLTLLALsATAVSHAEEkRYVSDELNTYVRSGPGDQYRIVGTLNAGEEVTLLQVNANTNYAQIRDSKGRTAWI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521101477  77 ESRFVTRDVSMAVRLPQLEKELADVKSKLANARQSADSEKAGLVDSLEVRNKQIAELEKNYSDISKQLTASQSEVRELRA 156
Cdd:PRK10884  81 PLKQLSTTPSLRTRVPDLENQVKTLTDKLNNIDNTWNQRTAEMQQKVAQSDSVINGLKEENQKLKNQLIVAQKKVDAANL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 521101477 157 KLDTQKEDLLLKYFMYGGGVAGGGLLLGLVLPHIIPRRKRN 197
Cdd:PRK10884 161 QLDDKQRTIIMQWFMYGGGVAGIGLLLGLLLPHLIPRRKRK 201
SH3_and_anchor TIGR04211
SH3 domain protein; Members of this protein family have a signal peptide, a strongly conserved ...
 23-201 4.33e-42

SH3 domain protein; Members of this protein family have a signal peptide, a strongly conserved SH3 domain, a variable region, and then a C-terminal hydrophobic transmembrane alpha helix region.


Pssm-ID: 275056 [Multi-domain]  Cd Length: 198  Bit Score: 140.53  E-value: 4.33e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521101477   23 YIADKLFTYMHSGPSNQYRIIGSIDAGEKVKLINTNKDTdYTQIVDERGRTGWVESRFVTRDVSMAVRLPQLEKELADVK 102
Cdd:TIGR04211   1 YISDELFVYMRSGPGNQYRILGSLKSGTPVTVLERSEDG-YSRVRTPKGREGWVLSRYLSDTPSARERLPELQQELAELQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521101477  103 SKLANARQSAD---SEKAGLVDSLEVRNKQIAELEKNYSDI-----------------SKQLTASQSEVRELRAKLDTQK 162
Cdd:TIGR04211  80 EELAELQEQLAelrQENQELKQQLSTLEAELEELQKELERIkqisanaieldeenrelREELAELKQENEALEAENERLQ 159

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 521101477  163 EDLLLKYFMYGGGVAGGGLLLGLVLPHIIPRRKRNPAGW 201
Cdd:TIGR04211 160 ENEQRRWFLYGGGVLFLGILLGLILPRLLPRRRRRSDGW 198
YgiM COG3103
Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family ...
 17-93 2.15e-21

Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family [General function prediction only];


Pssm-ID: 442337 [Multi-domain]  Cd Length: 119  Bit Score: 84.79  E-value: 2.15e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521101477  17 TFAQDRYIADKLFTYMHSGPSNQYRIIGSIDAGEKVKLIntNKDTDYTQIVDERGRTGWVESRFVTRDVSMAVRLPQ 93
Cdd:COG3103    1 AAAETRYVVDADALNVRSGPGTSYRIVGTLPKGEKVTVL--GRSGGWYKVRYSNGKTGWVSSRYLTVTPSARERLPD 75
SH3b smart00287
Bacterial SH3 domain homologues;
29-81 6.56e-09

Bacterial SH3 domain homologues;


Pssm-ID: 214600 [Multi-domain]  Cd Length: 63  Bit Score: 50.41  E-value: 6.56e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 521101477    29 FTYMHSGPSNQYRIIGSIDAGEKVKLINTnKDTDYTQIVDERGRTGWVESRFV 81
Cdd:smart00287  10 GLNVRTGPGTSSPIIGTLKKGDKVKVLGV-DGQDWAKITYGSGQRGYVPGYVV 61
SH3_3 pfam08239
Bacterial SH3 domain;
31-82 9.76e-09

Bacterial SH3 domain;


Pssm-ID: 462405 [Multi-domain]  Cd Length: 54  Bit Score: 49.55  E-value: 9.76e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 521101477   31 YMHSGPSNQYRIIGSIDAGEKVKLINTNKDtDYTQIVDERGRTGWVESRFVT 82
Cdd:pfam08239   4 NVRSGPSTSSEVVGTLPKGEKVEVLEEQGG-GWYKVRTYDGYEGWVSSSYLS 54
YraI COG4991
Uncharacterized conserved protein YraI [Function unknown];
1-85 2.93e-08

Uncharacterized conserved protein YraI [Function unknown];


Pssm-ID: 444015 [Multi-domain]  Cd Length: 92  Bit Score: 49.29  E-value: 2.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521101477   1 MKKLICMVLFSMLAAPT---FAQDRYIADKLFtyMHSGPSNQYRIIGSIDAGEKVKLINTNKDTDYTQiVDERGRTGWVE 77
Cdd:COG4991    1 MRRALLAAALALLLLAPaaaAAATAVATDDLN--LRSGPGTGYPVVGTLPAGATVTVLGCTSGGGWCK-VSYGGQRGWVS 77


                 ....*...
gi 521101477  78 SRFVTRDV 85
Cdd:COG4991   78 ARYLQVSY 85
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 90-165 4.16e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.30  E-value: 4.16e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 521101477  90 RLPQLEKELADVKSKLANARQSADS---EKAGLVDSLEVRNKQIAELEKNYSDISKQLTASQSEVRELRAKLDTQKEDL 165
Cdd:COG4942   28 ELEQLQQEIAELEKELAALKKEEKAllkQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEEL 106
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 84-153 1.71e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 38.52  E-value: 1.71e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 521101477  84 DVSMAVRLPQLEKELADVKSKLANARQSADSEKA------GLVDSLEVRNKQIAELEKNYSDISKQLTASQSEVRE 153
Cdd:COG0542  435 DEASFERLAELRDELAELEEELEALKARWEAEKElieeiqELKEELEQRYGKIPELEKELAELEEELAELAPLLRE 510
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 91-165 2.33e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 38.27  E-value: 2.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 521101477  91 LPQLEKELADVKSKLANARQSadsekaglVDSLevrNKQIAELEKNYSDISKQLTASQSEVRELRAKLDTQKEDL 165
Cdd:COG3883   18 IQAKQKELSELQAELEAAQAE--------LDAL---QAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEI 81
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 78-163 3.90e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 37.50  E-value: 3.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521101477  78 SRFVTRDVSMAVRLPQLEKELADVKSKLANARQSADSEKAGLVDSLEVRNKQIAELEKNYSDISKQLTASQSEVRELRAK 157
Cdd:COG3883  125 SKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAE 204


                 ....*.
gi 521101477 158 LDTQKE 163
Cdd:COG3883  205 LAAAEA 210
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
90-165 5.05e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 37.30  E-value: 5.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521101477  90 RLPQLEKELADVKSKLANARQSADSEKAGLVDSLEVRN------------KQIAELEKNYSDISKQLTASQSEVRELRAK 157
Cdd:COG3206  220 QLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPellqspviqqlrAQLAELEAELAELSARYTPNHPDVIALRAQ 299


                 ....*...
gi 521101477 158 LDTQKEDL 165
Cdd:COG3206  300 IAALRAQL 307
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
90-165 8.57e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 36.53  E-value: 8.57e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 521101477  90 RLPQLEKELADVKSKLANARQsadseKAGLVDSlevrNKQIAELEKNYSDISKQLTASQSEVRELRAKLDTQKEDL 165
Cdd:COG3206  183 QLPELRKELEEAEAALEEFRQ-----KNGLVDL----SEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQL 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH