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Conserved domains on  [gi|544824526|ref|WP_021240528|]
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MULTISPECIES: division/cell wall cluster transcriptional repressor MraZ [Enterobacterales]

Protein Classification

division/cell wall cluster transcriptional repressor MraZ( domain architecture ID 11478503)

division/cell wall cluster transcriptional repressor MraZ has been implicated in the regulation of the dcw gene cluster, which contains cell division genes such as ftsZ

CATH:  2.40.330.20
Gene Ontology:  GO:0003700|GO:0006355|GO:0000976|GO:0043565
PubMed:  15146477
SCOP:  4000936

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK00326 PRK00326
transcriptional regulator MraZ;
1-139 2.74e-75

transcriptional regulator MraZ;


:

Pssm-ID: 234728 [Multi-domain]  Cd Length: 139  Bit Score: 220.45  E-value: 2.74e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824526   1 MFRGATLVNLDSKGRLSVPTRYRDQLIENAAGQMVCTIDINsPCLLLYPLPEWEIIEQKLSRLSSMNPQERRVQRLLLGH 80
Cdd:PRK00326   1 MFRGEYAHNLDAKGRLSIPAKFRDELGEEADGRLVITKGLD-GCLLLYPLPEWEKIEEKLAALPLTNPEARAFQRLLLGG 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 544824526  81 ASECQMDNAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWYQQVKEDIDAEQSD 139
Cdd:PRK00326  80 AVEVELDKQGRILIPPNLREYAGLEKEVVLVGQGNKFEIWDPEAWEAYLAEAEEDFADD 138
 
Name Accession Description Interval E-value
PRK00326 PRK00326
transcriptional regulator MraZ;
1-139 2.74e-75

transcriptional regulator MraZ;


Pssm-ID: 234728 [Multi-domain]  Cd Length: 139  Bit Score: 220.45  E-value: 2.74e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824526   1 MFRGATLVNLDSKGRLSVPTRYRDQLIENAAGQMVCTIDINsPCLLLYPLPEWEIIEQKLSRLSSMNPQERRVQRLLLGH 80
Cdd:PRK00326   1 MFRGEYAHNLDAKGRLSIPAKFRDELGEEADGRLVITKGLD-GCLLLYPLPEWEKIEEKLAALPLTNPEARAFQRLLLGG 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 544824526  81 ASECQMDNAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWYQQVKEDIDAEQSD 139
Cdd:PRK00326  80 AVEVELDKQGRILIPPNLREYAGLEKEVVLVGQGNKFEIWDPEAWEAYLAEAEEDFADD 138
TIGR00242 TIGR00242
division/cell wall cluster transcriptional repressor MraZ; Members of this family contain two ...
 1-151 4.58e-75

division/cell wall cluster transcriptional repressor MraZ; Members of this family contain two tandem copies of a domain described by pfam02381. This protein often is found with other genes of the dcw (division cell wall) gene cluster, including mraW, ftsI, murE, murF, ftsW, murG, etc. Recent work shows MraW in E. coli binds an upstream region with three tandem GTGGG repeats separated by 5bp spacers. We find similar sites in other species. [Cellular processes, Cell division, Regulatory functions, DNA interactions]


Pssm-ID: 129345 [Multi-domain]  Cd Length: 142  Bit Score: 220.43  E-value: 4.58e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824526    1 MFRGATLVNLDSKGRLSVPTRYRDQLIENaagqmVCTIDINSPCLLLYPLPEWEIIEQKLSRLSSMNPQERRVQRLLLGH 80
Cdd:TIGR00242   1 MFRGATNVTLDAKGRISVPAKYRAFLLES-----VVTNRGFENCLLLYPLQEWEKIEQKLNALPSTQKDTRRLQRLIFGH 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544824526   81 ASECQMDNAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWYQQVKEDIDAEQSdsatLSERLQDLS 151
Cdd:TIGR00242  76 ATECEMDTAGRVLIANNLRNHAKLEKEIVLIGQFNKFEIWDKVLWEQYLAEDEDLETE----VAERMKDFS 142
MraZ COG2001
MraZ, DNA-binding transcriptional regulator and inhibitor of RsmH methyltransferase activity ...
 1-145 4.48e-66

MraZ, DNA-binding transcriptional regulator and inhibitor of RsmH methyltransferase activity [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441604 [Multi-domain]  Cd Length: 144  Bit Score: 197.36  E-value: 4.48e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824526   1 MFRGATLVNLDSKGRLSVPTRYRDQLIENAAGQMVCTIDINsPCLLLYPLPEWEIIEQKLSRLSSMNPQERRVQRLLLGH 80
Cdd:COG2001    1 MFLGTYEHKLDAKGRLSIPAKFRDVLAEELGGGLVLTRGLD-GCLELYPLEEWEKLEEKLEALPLFSPEARDFQRLFLGG 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544824526  81 ASECQMDNAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWYQQVKEDIDAEQSDSATLSE 145
Cdd:COG2001   80 ATEVELDKQGRILIPPNLREYAGLEKEVVLVGAGNRFEIWDPEAWEAYLAEAEEDFAELAEELGD 144
MraZ_C cd16321
C-terminal subdomain of transcriptional regulator MraZ; This family contains the C-terminal ...
 71-132 5.15e-25

C-terminal subdomain of transcriptional regulator MraZ; This family contains the C-terminal domain of proteins of unknown function (UPF0040), implicated in a cellular function of bacterial cell division. It includes protein MraZ which is present in almost all bacteria and appears to be essential for survival. It is found in gene clusters associated with the cellular function of cell division and cell wall biosynthesis, including mraW, ftsI, murE, murF, ftsW and murG. Members of this family contain two tandem copies of the domain; the crystal structure of a member of this family (MPN314) reveals that the two subdomains are related by a pseudo two-fold axis, with each subdomain containing a highly conserved DXXXR sequence motif in close proximity to each other, suggested to form the functional site.


Pssm-ID: 293784  Cd Length: 62  Bit Score: 90.62  E-value: 5.15e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544824526  71 RRVQRLLLGHASECQMDNAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWYQQVKED 132
Cdd:cd16321    1 RALLRLFLGGAEEVELDKQGRILLPQRLREYAGLEKEVVFVGVGDRFEIWDPERWEAYLAEA 62
MraZ pfam02381
MraZ protein, putative antitoxin-like; This small 70 amino acid domain is found duplicated in ...
 1-76 6.70e-23

MraZ protein, putative antitoxin-like; This small 70 amino acid domain is found duplicated in a family of bacterial proteins. These proteins may be DNA-binding transcription factors (Pers. comm. A Andreeva _ A Murzin). It is likely, due to the similarity of fold, that this family acts as a bacterial antitoxin like the MazE antitoxin family.


Pssm-ID: 426747  Cd Length: 72  Bit Score: 85.83  E-value: 6.70e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544824526    1 MFRGATLVNLDSKGRLSVPTRYRDQlienAAGQMVCTIDINSPCLLLYPLPEWEIIEQKLSRLSSMNPQERRVQRL 76
Cdd:pfam02381   1 MFGGATEVELDAKGRIILPAKLREH----AGLEKECVVIGQSNCLEIWPRAEWEQYEAELSEESFSAKAERALLRN 72
 
Name Accession Description Interval E-value
PRK00326 PRK00326
transcriptional regulator MraZ;
1-139 2.74e-75

transcriptional regulator MraZ;


Pssm-ID: 234728 [Multi-domain]  Cd Length: 139  Bit Score: 220.45  E-value: 2.74e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824526   1 MFRGATLVNLDSKGRLSVPTRYRDQLIENAAGQMVCTIDINsPCLLLYPLPEWEIIEQKLSRLSSMNPQERRVQRLLLGH 80
Cdd:PRK00326   1 MFRGEYAHNLDAKGRLSIPAKFRDELGEEADGRLVITKGLD-GCLLLYPLPEWEKIEEKLAALPLTNPEARAFQRLLLGG 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 544824526  81 ASECQMDNAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWYQQVKEDIDAEQSD 139
Cdd:PRK00326  80 AVEVELDKQGRILIPPNLREYAGLEKEVVLVGQGNKFEIWDPEAWEAYLAEAEEDFADD 138
TIGR00242 TIGR00242
division/cell wall cluster transcriptional repressor MraZ; Members of this family contain two ...
 1-151 4.58e-75

division/cell wall cluster transcriptional repressor MraZ; Members of this family contain two tandem copies of a domain described by pfam02381. This protein often is found with other genes of the dcw (division cell wall) gene cluster, including mraW, ftsI, murE, murF, ftsW, murG, etc. Recent work shows MraW in E. coli binds an upstream region with three tandem GTGGG repeats separated by 5bp spacers. We find similar sites in other species. [Cellular processes, Cell division, Regulatory functions, DNA interactions]


Pssm-ID: 129345 [Multi-domain]  Cd Length: 142  Bit Score: 220.43  E-value: 4.58e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824526    1 MFRGATLVNLDSKGRLSVPTRYRDQLIENaagqmVCTIDINSPCLLLYPLPEWEIIEQKLSRLSSMNPQERRVQRLLLGH 80
Cdd:TIGR00242   1 MFRGATNVTLDAKGRISVPAKYRAFLLES-----VVTNRGFENCLLLYPLQEWEKIEQKLNALPSTQKDTRRLQRLIFGH 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544824526   81 ASECQMDNAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWYQQVKEDIDAEQSdsatLSERLQDLS 151
Cdd:TIGR00242  76 ATECEMDTAGRVLIANNLRNHAKLEKEIVLIGQFNKFEIWDKVLWEQYLAEDEDLETE----VAERMKDFS 142
MraZ COG2001
MraZ, DNA-binding transcriptional regulator and inhibitor of RsmH methyltransferase activity ...
 1-145 4.48e-66

MraZ, DNA-binding transcriptional regulator and inhibitor of RsmH methyltransferase activity [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441604 [Multi-domain]  Cd Length: 144  Bit Score: 197.36  E-value: 4.48e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824526   1 MFRGATLVNLDSKGRLSVPTRYRDQLIENAAGQMVCTIDINsPCLLLYPLPEWEIIEQKLSRLSSMNPQERRVQRLLLGH 80
Cdd:COG2001    1 MFLGTYEHKLDAKGRLSIPAKFRDVLAEELGGGLVLTRGLD-GCLELYPLEEWEKLEEKLEALPLFSPEARDFQRLFLGG 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544824526  81 ASECQMDNAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWYQQVKEDIDAEQSDSATLSE 145
Cdd:COG2001   80 ATEVELDKQGRILIPPNLREYAGLEKEVVLVGAGNRFEIWDPEAWEAYLAEAEEDFAELAEELGD 144
MraZ_C cd16321
C-terminal subdomain of transcriptional regulator MraZ; This family contains the C-terminal ...
 71-132 5.15e-25

C-terminal subdomain of transcriptional regulator MraZ; This family contains the C-terminal domain of proteins of unknown function (UPF0040), implicated in a cellular function of bacterial cell division. It includes protein MraZ which is present in almost all bacteria and appears to be essential for survival. It is found in gene clusters associated with the cellular function of cell division and cell wall biosynthesis, including mraW, ftsI, murE, murF, ftsW and murG. Members of this family contain two tandem copies of the domain; the crystal structure of a member of this family (MPN314) reveals that the two subdomains are related by a pseudo two-fold axis, with each subdomain containing a highly conserved DXXXR sequence motif in close proximity to each other, suggested to form the functional site.


Pssm-ID: 293784  Cd Length: 62  Bit Score: 90.62  E-value: 5.15e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544824526  71 RRVQRLLLGHASECQMDNAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWYQQVKED 132
Cdd:cd16321    1 RALLRLFLGGAEEVELDKQGRILLPQRLREYAGLEKEVVFVGVGDRFEIWDPERWEAYLAEA 62
MraZ pfam02381
MraZ protein, putative antitoxin-like; This small 70 amino acid domain is found duplicated in ...
 1-76 6.70e-23

MraZ protein, putative antitoxin-like; This small 70 amino acid domain is found duplicated in a family of bacterial proteins. These proteins may be DNA-binding transcription factors (Pers. comm. A Andreeva _ A Murzin). It is likely, due to the similarity of fold, that this family acts as a bacterial antitoxin like the MazE antitoxin family.


Pssm-ID: 426747  Cd Length: 72  Bit Score: 85.83  E-value: 6.70e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544824526    1 MFRGATLVNLDSKGRLSVPTRYRDQlienAAGQMVCTIDINSPCLLLYPLPEWEIIEQKLSRLSSMNPQERRVQRL 76
Cdd:pfam02381   1 MFGGATEVELDAKGRIILPAKLREH----AGLEKECVVIGQSNCLEIWPRAEWEQYEAELSEESFSAKAERALLRN 72
MraZ pfam02381
MraZ protein, putative antitoxin-like; This small 70 amino acid domain is found duplicated in ...
 77-149 7.78e-21

MraZ protein, putative antitoxin-like; This small 70 amino acid domain is found duplicated in a family of bacterial proteins. These proteins may be DNA-binding transcription factors (Pers. comm. A Andreeva _ A Murzin). It is likely, due to the similarity of fold, that this family acts as a bacterial antitoxin like the MazE antitoxin family.


Pssm-ID: 426747  Cd Length: 72  Bit Score: 80.44  E-value: 7.78e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544824526   77 LLGHASECQMDNAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWYQQVKEDIDAeqsDSATLSERLQD 149
Cdd:pfam02381   1 MFGGATEVELDAKGRIILPAKLREHAGLEKECVVIGQSNCLEIWPRAEWEQYEAELSEE---SFSAKAERALL 70
MraZ_N cd16320
N-terminal subdomain of transcriptional regulator MraZ; This family contains the N-terminal ...
 3-64 4.24e-18

N-terminal subdomain of transcriptional regulator MraZ; This family contains the N-terminal domain of proteins of unknown function (UPF0040), implicated in a cellular function of bacterial cell division. It includes protein MraZ which is present in almost all bacteria and appears to be essential for survival. It is found in gene clusters associated with the cellular function of cell division and cell wall biosynthesis, including mraW, ftsI, murE, murF, ftsW and murG. Members of this family contain two tandem copies of the domain; the crystal structure of a member of this family (MPN314) reveals that the two subdomains are related by a pseudo two-fold axis, with each subdomain containing a highly conserved DXXXR sequence motif in close proximity to each other, suggested to form the functional site.


Pssm-ID: 293783  Cd Length: 60  Bit Score: 72.92  E-value: 4.24e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544824526   3 RGATLVNLDSKGRLSVPTRYRDQLiENAAGQMVCTIDINsPCLLLYPLPEWEIIEQKLSRLS 64
Cdd:cd16320    1 LGTYEHKLDAKGRLSIPAKFREEL-GAGGEGLVLTRGLD-GCLELYPLEEWEKLEEKLEALP 60
MraZ cd16319
protein domain of unknown function (UPF0040) includes MraZ; This family contains proteins of ...
 86-121 8.93e-03

protein domain of unknown function (UPF0040) includes MraZ; This family contains proteins of unknown function (UPF0040), implicated in a cellular function of bacterial cell division. It includes protein MraZ which is present in almost all bacteria and appears to be essential for survival. It is found in gene clusters associated with the cellular function of cell division and cell wall biosynthesis. Members of this family contain two tandem copies of the domain; the crystal structure of a member of this family (MPN314) reveals that the two subdomains are related by a pseudo two-fold axis, with each subdomain containing a highly conserved DXXXR sequence motif in close proximity to each other, suggested to form the functional site.


Pssm-ID: 293782  Cd Length: 53  Bit Score: 33.03  E-value: 8.93e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 544824526  86 MDNAGRLLIAPVLRQHAGLTKEVMLVGQF-NKFELWD 121
Cdd:cd16319    6 LDAAGRILIPAKLIADAELDGEIVIIGGFeDCLEIRD 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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