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Conserved domains on  [gi|640683276|ref|WP_025107744|]
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MULTISPECIES: glycosyltransferase family 4 protein [Klebsiella]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133538)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 7-372 3.96e-120

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


:

Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 351.90  E-value: 3.96e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276   7 KLCYFINSDWYFDLHWIDRAIAARDAGYEIHIISHfVDGKVLNKFKTFGFKCHNVPLDAQSFNALTFFRAFFASRKLIKE 86
Cdd:cd03808    1 KILFIVNVDGGFQSFRLPLIKALVKKGYEVHVIAP-DGDKLSDELKELGVKVIDIPILRRGINPLKDLKALFKLYKLLKK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  87 INPDLLHCITIKPCLIGGLLSRTNNRPVIVSFV-GLGRVFSGDtgllKLLRNITIMAYKYIASNKRSIFmFEHDKDRKKL 165
Cdd:cd03808   80 EKPDIVHCHTPKPGILGRLAARLAGVPKVIYTVhGLGFVFTEG----KLLRLLYLLLEKLALLFTDKVI-FVNEDDRDLA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 166 AGFVGIDYQQTIVIDGAGINPEIYKYSLEQ-ERDVPVVLFASRMLWSKGLGDLIEAKKILEARNIHFTLNVAGILVENDK 244
Cdd:cd03808  155 IKKGIIKKKKTVLIPGSGVDLDRFQYSPESlPSEKVVFLFVARLLKDKGIDELIEAAKILKKKGPNVRFLLVGDGELENP 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 245 DAISlavIQQWHKEGLINWLGHSSNVCDLIEESNIVALPSIYsEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGII 324
Cdd:cd03808  235 SEIL---IEKLGLEGRIEFLGFRSDVPELLAESDVFVLPSYR-EGLPRSLLEAMAAGRPVITTDVPGCRELVIDGVNGFL 310

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 640683276 325 VKSNSPQELADKLEFLLANPKARVEMGIKGRQRVQDKFSSGMIISKTL 372
Cdd:cd03808  311 VPPGDVEALADAIEKLIEDPELRKEMGEAARKRVEEKFDEEKVVNKLL 358
 
Name Accession Description Interval E-value
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 7-372 3.96e-120

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 351.90  E-value: 3.96e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276   7 KLCYFINSDWYFDLHWIDRAIAARDAGYEIHIISHfVDGKVLNKFKTFGFKCHNVPLDAQSFNALTFFRAFFASRKLIKE 86
Cdd:cd03808    1 KILFIVNVDGGFQSFRLPLIKALVKKGYEVHVIAP-DGDKLSDELKELGVKVIDIPILRRGINPLKDLKALFKLYKLLKK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  87 INPDLLHCITIKPCLIGGLLSRTNNRPVIVSFV-GLGRVFSGDtgllKLLRNITIMAYKYIASNKRSIFmFEHDKDRKKL 165
Cdd:cd03808   80 EKPDIVHCHTPKPGILGRLAARLAGVPKVIYTVhGLGFVFTEG----KLLRLLYLLLEKLALLFTDKVI-FVNEDDRDLA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 166 AGFVGIDYQQTIVIDGAGINPEIYKYSLEQ-ERDVPVVLFASRMLWSKGLGDLIEAKKILEARNIHFTLNVAGILVENDK 244
Cdd:cd03808  155 IKKGIIKKKKTVLIPGSGVDLDRFQYSPESlPSEKVVFLFVARLLKDKGIDELIEAAKILKKKGPNVRFLLVGDGELENP 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 245 DAISlavIQQWHKEGLINWLGHSSNVCDLIEESNIVALPSIYsEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGII 324
Cdd:cd03808  235 SEIL---IEKLGLEGRIEFLGFRSDVPELLAESDVFVLPSYR-EGLPRSLLEAMAAGRPVITTDVPGCRELVIDGVNGFL 310

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 640683276 325 VKSNSPQELADKLEFLLANPKARVEMGIKGRQRVQDKFSSGMIISKTL 372
Cdd:cd03808  311 VPPGDVEALADAIEKLIEDPELRKEMGEAARKRVEEKFDEEKVVNKLL 358
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 198-357 8.02e-25

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 98.89  E-value: 8.02e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  198 DVPVVLFASRMLWSKGLGDLIEAKKILEARNIHFTLNVAGILVENDKdAISLAviqqwHKEGL---INWLGHSSNVcDLI 274
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKR-LKKLA-----EKLGLgdnVIFLGFVSDE-DLP 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  275 EE---SNIVALPSIYsEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGIIVKSNSPQELADKLEFLLANPKARVEMG 351
Cdd:pfam00534  74 ELlkiADVFVLPSRY-EGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPNNAEALAEAIDKLLEDEELRERLG 152


                  ....*.
gi 640683276  352 IKGRQR 357
Cdd:pfam00534 153 ENARKR 158
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 269-380 3.65e-23

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 93.52  E-value: 3.65e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 269 NVCDLIE----ESNIVALPSIYsEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGIIVKSNSPQELADKLEFLLANP 344
Cdd:COG0438    9 GLDLLLEallaAADVFVLPSRS-EGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAILRLLEDP 87

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 640683276 345 KARVEMGIKGRQRVQDKFSSGMIISKTLKTYHDVVQ 380
Cdd:COG0438   88 ELRRRLGEAARERAEERFSWEAIAERLLALYEELLA 123
PelF NF038011
GT4 family glycosyltransferase PelF; Proteins of this family are components of the ...
 269-349 1.86e-04

GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter.


Pssm-ID: 411604 [Multi-domain]  Cd Length: 489  Bit Score: 43.38  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 269 NVCDLIEESNIVALPSIySEGVPRILLEASSVGRACIAYDVGGCDSLIINNDN--------GIIVKSNSPQELADKLEFL 340
Cdd:NF038011 376 KIDDLLPQVGLMVLSSI-SEALPLVVLEAFAAGVPVVTTDVGSCRQLIEGLDEedralgaaGEVVAIADPQALARAALDL 454

                         90
                 ....*....|....*....
gi 640683276 341 LANPK----------ARVE 349
Cdd:NF038011 455 LRDPQrwqaaqaaglARVE 473
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
194-337 5.83e-03

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 38.54  E-value: 5.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 194 EQERDVP-VVLFASRMLW--SKGLGDLIEAkkiLEARNIHFTLNVAGilvENDKDAISLAVIQQWHKEGLINWLGHSSN- 269
Cdd:PRK09922 174 PPERDKPaVFLYVGRLKFegQKNVKELFDG---LSQTTGEWQLHIIG---DGSDFEKCKAYSRELGIEQRIIWHGWQSQp 247

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 640683276 270 ---VCDLIEESNIVALPSIYsEGVPRILLEASSVGRACIAYD-VGGCDSLIINNDNGIIVKSNSPQELADKL 337
Cdd:PRK09922 248 wevVQQKIKNVSALLLTSKF-EGFPMTLLEAMSYGIPCISSDcMSGPRDIIKPGLNGELYTPGNIDEFVGKL 318
 
Name Accession Description Interval E-value
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 7-372 3.96e-120

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 351.90  E-value: 3.96e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276   7 KLCYFINSDWYFDLHWIDRAIAARDAGYEIHIISHfVDGKVLNKFKTFGFKCHNVPLDAQSFNALTFFRAFFASRKLIKE 86
Cdd:cd03808    1 KILFIVNVDGGFQSFRLPLIKALVKKGYEVHVIAP-DGDKLSDELKELGVKVIDIPILRRGINPLKDLKALFKLYKLLKK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  87 INPDLLHCITIKPCLIGGLLSRTNNRPVIVSFV-GLGRVFSGDtgllKLLRNITIMAYKYIASNKRSIFmFEHDKDRKKL 165
Cdd:cd03808   80 EKPDIVHCHTPKPGILGRLAARLAGVPKVIYTVhGLGFVFTEG----KLLRLLYLLLEKLALLFTDKVI-FVNEDDRDLA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 166 AGFVGIDYQQTIVIDGAGINPEIYKYSLEQ-ERDVPVVLFASRMLWSKGLGDLIEAKKILEARNIHFTLNVAGILVENDK 244
Cdd:cd03808  155 IKKGIIKKKKTVLIPGSGVDLDRFQYSPESlPSEKVVFLFVARLLKDKGIDELIEAAKILKKKGPNVRFLLVGDGELENP 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 245 DAISlavIQQWHKEGLINWLGHSSNVCDLIEESNIVALPSIYsEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGII 324
Cdd:cd03808  235 SEIL---IEKLGLEGRIEFLGFRSDVPELLAESDVFVLPSYR-EGLPRSLLEAMAAGRPVITTDVPGCRELVIDGVNGFL 310

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 640683276 325 VKSNSPQELADKLEFLLANPKARVEMGIKGRQRVQDKFSSGMIISKTL 372
Cdd:cd03808  311 VPPGDVEALADAIEKLIEDPELRKEMGEAARKRVEEKFDEEKVVNKLL 358
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 25-376 4.36e-38

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 140.37  E-value: 4.36e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  25 RAIAARdaGYEIHIISHFVDGKVLNKFKTFGFkchnVPLDAQSFNALTFFRAFFASRKLIKEINPDLLHCITIKPCLIGG 104
Cdd:cd03801   25 RALAAR--GHDVTVLTPADPGEPPEELEDGVI----VPLLPSLAALLRARRLLRELRPLLRLRKFDVVHAHGLLAALLAA 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 105 LLSRTNNRPVIVSFVGL--GRVFSGDTGLLKLLRNITIMAYKYiasnKRSIFMFEHDKDRkkLAGFVGIDYQQTIVIdGA 182
Cdd:cd03801   99 LLALLLGAPLVVTLHGAepGRLLLLLAAERRLLARAEALLRRA----DAVIAVSEALRDE--LRALGGIPPEKIVVI-PN 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 183 GINPEIYKYSLEQE----RDVPVVLFASRMLWSKGLGDLIEAKKILEARNIHFTLNVAGilvenDKDAISLAVIQQWHKE 258
Cdd:cd03801  172 GVDLERFSPPLRRKlgipPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVG-----GDGPLRAELEELELGL 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 259 GL-INWLGHSSN--VCDLIEESNIVALPSIYsEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGIIVKSNSPQELAD 335
Cdd:cd03801  247 GDrVRFLGFVPDeeLPALYAAADVFVLPSRY-EGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPPDDVEALAD 325

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 640683276 336 KLEFLLANPKARVEMGIKGRQRVQDKFSSGMIISKTLKTYH 376
Cdd:cd03801  326 ALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLYR 366
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 29-376 2.71e-27

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 110.87  E-value: 2.71e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  29 ARDAGYEIHIISHFVDGKVLNKFKTFGfkchnVPLDAQSFNALTFFRAFFASRKLIKEINPDLLHCITIKPCLIGGLLSR 108
Cdd:cd03807   25 MDKSRFEHVVISLTGDGVLGEELLAAG-----VPVVCLGLSSGKDPGVLLRLAKLIRKRNPDVVHTWMYHADLIGGLAAK 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 109 TN-NRPVIVSF--VGLGRVFSGDTGLLKLLRNITIMAYKYIaSNKRSIFMFEhdkdrkklagfVGIDYQQTIVIDGaGIN 185
Cdd:cd03807  100 LAgGVKVIWSVrsSNIPQRLTRLVRKLCLLLSKFSPATVAN-SSAVAEFHQE-----------QGYAKNKIVVIYN-GID 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 186 PEIYKYSLEQ----------ERDVPVVLFASRMLWSKGLGDLIEA-KKILEAR-NIHFTLNVAGILVENdkdaiSLAVIQ 253
Cdd:cd03807  167 LFKLSPDDASrararrrlglAEDRRVIGIVGRLHPVKDHSDLLRAaALLVETHpDLRLLLVGRGPERPN-----LERLLL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 254 QWHKEGLINWLGHSSNVCDLIEESNIVALPSIYsEGVPRILLEASSVGRACIAYDVGGCdSLIINNDNGIIVKSNSPQEL 333
Cdd:cd03807  242 ELGLEDRVHLLGERSDVPALLPAMDIFVLSSRT-EGFPNALLEAMACGLPVVATDVGGA-AELVDDGTGFLVPAGDPQAL 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 640683276 334 ADKLEFLLANPKARVEMGIKGRQRVQDKFSSGMIISKTLKTYH 376
Cdd:cd03807  320 ADAIRALLEDPEKRARLGRAARERIANEFSIDAMVRRYETLYY 362
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 60-357 1.96e-26

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 108.21  E-value: 1.96e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  60 NVPLDAQSFNALTFFRAFFASRKLIKEINPDLLHCITIKPCLIGGLLSRTNNRPVIVSFVGLGRVfSGDTGLLKLLRNIT 139
Cdd:cd03819   48 GIGLPGLKVPLLRALLGNVRLARLIRRERIDLIHAHSRAPAWLGWLASRLTGVPLVTTVHGSYLA-TYHPKDFALAVRAR 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 140 ImAYKYIASNKRSIFMFEH---DKDRKKLAgFVGIDYQQTiviDGAGINPEIYKYSLEqeRDVPVVLFASRMLWSKGLGD 216
Cdd:cd03819  127 G-DRVIAVSELVRDHLIEAlgvDPERIRVI-PNGVDTDRF---PPEAEAEERAQLGLP--EGKPVVGYVGRLSPEKGWLL 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 217 LIEAKKILEARnIHFTLNVAGILVENDKDAislAVIQQWHKEGLINWLGHSSNVCDLIEESNIVALPSIYsEGVPRILLE 296
Cdd:cd03819  200 LVDAAAELKDE-PDFRLLVAGDGPERDEIR---RLVERLGLRDRVTFTGFREDVPAALAASDVVVLPSLH-EEFGRVALE 274

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 640683276 297 ASSVGRACIAYDVGGCDSLIINNDNGIIVKSNSPQELADKLEFLLANPKARVEMGIKGRQR 357
Cdd:cd03819  275 AMACGTPVVATDVGGAREIVVHGRTGLLVPPGDAEALADAIRAAKLLPEAREKLQAAAALT 335
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 198-357 8.02e-25

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 98.89  E-value: 8.02e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  198 DVPVVLFASRMLWSKGLGDLIEAKKILEARNIHFTLNVAGILVENDKdAISLAviqqwHKEGL---INWLGHSSNVcDLI 274
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKR-LKKLA-----EKLGLgdnVIFLGFVSDE-DLP 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  275 EE---SNIVALPSIYsEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGIIVKSNSPQELADKLEFLLANPKARVEMG 351
Cdd:pfam00534  74 ELlkiADVFVLPSRY-EGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPNNAEALAEAIDKLLEDEELRERLG 152


                  ....*.
gi 640683276  352 IKGRQR 357
Cdd:pfam00534 153 ENARKR 158
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 269-380 3.65e-23

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 93.52  E-value: 3.65e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 269 NVCDLIE----ESNIVALPSIYsEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGIIVKSNSPQELADKLEFLLANP 344
Cdd:COG0438    9 GLDLLLEallaAADVFVLPSRS-EGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAILRLLEDP 87

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 640683276 345 KARVEMGIKGRQRVQDKFSSGMIISKTLKTYHDVVQ 380
Cdd:COG0438   88 ELRRRLGEAARERAEERFSWEAIAERLLALYEELLA 123
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 31-370 2.19e-22

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 96.92  E-value: 2.19e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  31 DAGYEIHIISHF---------VDGKVlnKFKTFGfkchnVPLDAQSFNALTFFRAFFASRKLIKEINPD----------- 90
Cdd:cd03820   28 KKGYDVTIISLDsaekppfyeLDDNI--KIKNLG-----DRKYSHFKLLLKYFKKVRRLRKYLKNNKPDvvisfrtsllt 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  91 LLHCITIKPCLIGGLLSRTNNRPVIVSFVGLGRVfsgdtgLLKLLRNITIMAykyiasnkrsifmfEHDKDRKKLAGFVG 170
Cdd:cd03820  101 FLALIGLKSKLIVWEHNNYEAYNKGLRRLLLRRL------LYKRADKIVVLT--------------EADKLKKYKQPNSN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 171 IDYQQTIVIDgagiNPEIYKYSLEQERdvpvVLFASRMLWSKGLGDLIEAKKILEARNIHFTLNVAGilvENDKDAISLA 250
Cdd:cd03820  161 VVVIPNPLSF----PSEEPSTNLKSKR----ILAVGRLTYQKGFDLLIEAWALIAKKHPDWKLRIYG---DGPEREELEK 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 251 VIQQWHKEGLINWLGHSSNVCDLIEESNIVALPSIYsEGVPRILLEASSVGRACIAYDvggCDS----LIINNDNGIIVK 326
Cdd:cd03820  230 LIDKLGLEDRVKLLGPTKNIAEEYANSSIFVLSSRY-EGFPMVLLEAMAYGLPIISFD---CPTgpseIIEDGENGLLVP 305

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 640683276 327 SNSPQELADKLEFLLANPKARVEMGIKGRQRVqDKFSSGMIISK 370
Cdd:cd03820  306 NGDVDALAEALLRLMEDEELRKKMGKNARKNA-ERFSIEKIIKQ 348
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 23-378 1.23e-21

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 95.14  E-value: 1.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  23 IDRAIAARDAGYEIHIISHFVDGKVLNKFKTFGFKCHNVPLDAqsfNALTFFR-------AFFAS--RKLIKEIN---PD 90
Cdd:cd03798   21 RRQVRALSRRGVDVEVLAPAPWGPAAARLLRKLLGEAVPPRDG---RRLLPLKprlrllaPLRAPslAKLLKRRRrgpPD 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  91 LLHCITIKPCLIGG-LLSRTNNRPVIVSFvgLGR---VFSGDTGLLKLLRNITIMAYKYIASNKRsifmfehDKDRKKLA 166
Cdd:cd03798   98 LIHAHFAYPAGFAAaLLARLYGVPYVVTE--HGSdinVFPPRSLLRKLLRWALRRAARVIAVSKA-------LAEELVAL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 167 GFvgidYQQTIVIDGAGINPEIYKYSLEQER---DVPVVLFASRMLWSKGLGDLIEAKKILEARNIHFTLNVAGILVenD 243
Cdd:cd03798  169 GV----PRDRVDVIPNGVDPARFQPEDRGLGlplDAFVILFVGRLIPRKGIDLLLEAFARLAKARPDVVLLIVGDGP--L 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 244 KDAISlAVIQQWHKEGLINWLGHSSN--VCDLIEESNIVALPSiYSEGVPRILLEASSVGRACIAYDVGGCDSLIINNDN 321
Cdd:cd03798  243 REALR-ALAEDLGLGDRVTFTGRLPHeqVPAYYRACDVFVLPS-RHEGFGLVLLEAMACGLPVVATDVGGIPEVVGDPET 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 640683276 322 GIIVKSNSPQELADKLEFLLANPKARvEMGIKGRQRVQDKFSSGMIISKTLKTYHDV 378
Cdd:cd03798  321 GLLVPPGDADALAAALRRALAEPYLR-ELGEAARARVAERFSWVKAADRIAAAYRDV 376
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
200-343 2.66e-21

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 88.72  E-value: 2.66e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  200 PVVLFASRML-WSKGLGDLIEAKKILEARNIHFTLNVAGilvendkDAISLAVIQQWHK-EGLINWLGHSSNVCDLIEES 277
Cdd:pfam13692   2 PVILFVGRLHpNVKGVDYLLEAVPLLRKRDNDVRLVIVG-------DGPEEELEELAAGlEDRVIFTGFVEDLAELLAAA 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640683276  278 NIVALPSIYsEGVPRILLEASSVGRACIAYDVGGCdSLIINNDNGIIVKSNSPQELADKLEFLLAN 343
Cdd:pfam13692  75 DVFVLPSLY-EGFGLKLLEAMAAGLPVVATDVGGI-PELVDGENGLLVPPGDPEALAEAILRLLED 138
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 26-344 3.09e-20

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 90.88  E-value: 3.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  26 AIAARDAGYEIHIIShFVDGKVLNKFKTFGFKCHNVPLDAQSFNALTFFRAFFASRKLIKEINPDLLHCITIKPCLIGGL 105
Cdd:cd03811   22 ANALDKRGYDVTLVL-LRDEGDLDKQLNGDVKLIRLLIRVLKLIKLGLLKAILKLKRILKRAKPDVVISFLGFATYIVAK 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 106 LSRTNNRPVIV---SFVGLGRVFSGDTGLLKLLRNitimaYKYIASNKRSIfmfehdkdRKKLAGFVGIDYQQTIV---- 178
Cdd:cd03811  101 LAAARSKVIAWihsSLSKLYYLKKKLLLKLKLYKK-----ADKIVCVSKGI--------KEDLIRLGPSPPEKIEViynp 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 179 IDGAGINPEIYKYSLEQERDVPVVLFASRMLWSKGLGDLIEAKKILEARNIHFTLNVAGilvENDKDAISLAVIQQWHKE 258
Cdd:cd03811  168 IDIDRIRALAKEPILNEPEDGPVILAVGRLDPQKGHDLLIEAFAKLRKKYPDVKLVILG---DGPLREELEKLAKELGLA 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 259 GLINWLGHSSNVCDLIEESNIVALPSIYsEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGIIVKSNSPQELADKLE 338
Cdd:cd03811  245 ERVIFLGFQSNPYPYLKKADLFVLSSRY-EGFPNVLLEAMALGTPVVSTDCPGPREILDDGENGLLVPDGDAAALAGILA 323


                 ....*.
gi 640683276 339 FLLANP 344
Cdd:cd03811  324 ALLQKK 329
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 90-367 1.52e-19

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 89.70  E-value: 1.52e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  90 DLLHCI-TIKPCLIGGLLSRTNNRPVIVSFVG---------LGRVFSGDTGLLKLL----RNITIMAYKYIAsnkRSIFM 155
Cdd:cd03813  175 DLYHSVsTGYAGLLGALARHRRGIPFLLTEHGiytrerkieILQSTWIMGYIKKLWirffERLGKLAYQQAD---KIISL 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 156 FEHDKDRKKLagfVGIDYQQTIVIDGaGINPEIYKYSLEQ--ERDVPVVLFASRMLWSKGLGDLIEAKKILEARNIHFTL 233
Cdd:cd03813  252 YEGNRRRQIR---LGADPDKTRVIPN-GIDIQRFAPAREErpEKEPPVVGLVGRVVPIKDVKTFIRAFKLVRRAMPDAEG 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 234 NVAGILVEN-DKDAISLAVIQQWHKEGLINWLGHSsNVCDLIEESNIVALPSIySEGVPRILLEASSVGRACIAYDVGGC 312
Cdd:cd03813  328 WLIGPEDEDpEYAQECKRLVASLGLENKVKFLGFQ-NIKEYYPKLGLLVLTSI-SEGQPLVILEAMASGVPVVATDVGSC 405

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 640683276 313 DSLIINNDN-----GIIVKSNSPQELADKLEFLLANPKARVEMGIKGRQRVQDKFS-SGMI 367
Cdd:cd03813  406 RELIYGADDalgqaGLVVPPADPEALAEALIKLLRDPELRQAFGEAGRKRVEKYYTlEGMI 466
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 9-363 9.13e-17

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 80.85  E-value: 9.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276   9 CYFINSDWYFDLHWIDRAIAARDAGYEIHIISHF---------------VDGKVLNKFKTFGFKCHNvpLDAQSFNALTF 73
Cdd:cd03794    7 QYYPPPKGAAAARVYELAKELVRRGHEVTVLTPSpnyplgrifagatetKDGIRVIRVKLGPIKKNG--LIRRLLNYLSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  74 FRAFFASRkLIKEINPDLLHCITIKP--CLIGGLLSRTNNRPVIV--------SFVGLGRVFSGdtGLLKLLRNItimaY 143
Cdd:cd03794   85 ALAALLKL-LVREERPDVIIAYSPPItlGLAALLLKKLRGAPFILdvrdlwpeSLIALGVLKKG--SLLKLLKKL----E 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 144 KYIASN-KRSIFMfehDKDRKKLAGFVGIDYQQTIVI------DGAGINPEIYKYSLEQERDVPVVLFASRMLWSKGLGD 216
Cdd:cd03794  158 RKLYRLaDAIIVL---SPGLKEYLLRKGVPKEKIIVIpnwadlEEFKPPPKDELRKKLGLDDKFVVVYAGNIGKAQGLET 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 217 LIEAKKILEAR-NIHFTLNVAGILVENDKDAISLAVIQQWHKEGLINW--LGHSSNVCDLieesNIVALPS--IYSEGVP 291
Cdd:cd03794  235 LLEAAERLKRRpDIRFLFVGDGDEKERLKELAKARGLDNVTFLGRVPKeeVPELLSAADV----GLVPLKDnpANRGSSP 310

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 640683276 292 RILLEASSVGRACIAYDVGGCDSLIINNDNGIIVKSNSPQELADKLEFLLANPKARVEMGIKGRQRVQDKFS 363
Cdd:cd03794  311 SKLFEYMAAGKPILASDDGGSDLAVEINGCGLVVEPGDPEALADAILELLDDPELRRAMGENGRELAEEKFS 382
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 182-378 1.78e-16

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 80.07  E-value: 1.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 182 AGINPEIYKYSLEQERDVPVVLFASRML--WSKGLGDLIEA-KKILEARNIhfTLNVAGILVENDKDAislaviqqwhkE 258
Cdd:cd03825  176 APVDKAKARKRLGIPQDKKVILFGAESVtkPRKGFDELIEAlKLLATKDDL--LLVVFGKNDPQIVIL-----------P 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 259 GLINWLGHSSNVCDLIEESN---IVALPSiYSEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGIIVKSNSPQELAD 335
Cdd:cd03825  243 FDIISLGYIDDDEQLVDIYSaadLFVHPS-LADNLPNTLLEAMACGTPVVAFDTGGSPEIVQHGVTGYLVPPGDVQALAE 321

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 640683276 336 KLEFLLANPKARVEMGIKGRQRVQDKFSSGMIISKTLKTYHDV 378
Cdd:cd03825  322 AIEWLLANPKERESLGERARALAENHFDQRVQAQRYLELYKDL 364
Glyco_trans_4_2 pfam13477
Glycosyl transferase 4-like;
7-122 4.22e-14

Glycosyl transferase 4-like;


Pssm-ID: 433241 [Multi-domain]  Cd Length: 139  Bit Score: 68.89  E-value: 4.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276    7 KLCYFINSDWYFDLHWIDraiAARDAGYEIHIISHfvdgKVLNKFKTFGFKCHNVPLDAQSFNALTFFRAFfASRKLIKE 86
Cdd:pfam13477   1 KILLLANADSIHTLRWAD---ALADRGYDVHVISS----KGPAKDELIAEGIHVHRLKVPRKGPLGYLKAF-RLKKLIKK 72

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 640683276   87 INPDLLHCITIKPC-LIGGLLSRTNNR-PVIVSFVGLG 122
Cdd:pfam13477  73 IKPDVVHVHYAKPYgLLAGLAARLSGFpPVVLSAWGLD 110
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 183-362 1.42e-13

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 71.33  E-value: 1.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 183 GINPEIYKYSLEQERDvPVVLFASRMLWSKGLGDLIEAKKILEARNIHFTLNVAGilvendkDAISLAVIQQWHKEG--- 259
Cdd:cd05844  174 GIDPAKFAPRDPAERA-PTILFVGRLVEKKGCDVLIEAFRRLAARHPTARLVIAG-------DGPLRPALQALAAALgrv 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 260 -LINWLGHsSNVCDLIEESNIVALPSIY-----SEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGIIVKSNSPQEL 333
Cdd:cd05844  246 rFLGALPH-AEVQDWMRRAEIFCLPSVTaasgdSEGLGIVLLEAAACGVPVVSSRHGGIPEAILDGETGFLVPEGDVDAL 324

                        170       180
                 ....*....|....*....|....*....
gi 640683276 334 ADKLEFLLANPKARVEMGIKGRQRVQDKF 362
Cdd:cd05844  325 ADALQALLADRALADRMGGAARAFVCEQF 353
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 200-364 5.80e-13

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 69.23  E-value: 5.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 200 PVVLFASRMLWSKGLGDLIEAKKILearNIHFTLNVAGILVENDKDAISLAVIQQwhkeglINWLGHSSNV--CDLIEES 277
Cdd:cd03795  192 KIFLFIGRLVYYKGLDYLIEAAQYL---NYPIVIGGEGPLKPDLEAQIELNLLDN------VKFLGRVDDEekVIYLHLC 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 278 NIVALPSIY-SEGVPRILLEASSVGRACIAYDVGGCDSLIINN-DNGIIVKSNSPQELADKLEFLLANPKARVEMGIKGR 355
Cdd:cd03795  263 DVFVFPSVLrSEAFGIVLLEAMMCGKPVISTNIGTGVPYVNNNgETGLVVPPKDPDALAEAIDKLLSDEELRESYGENAK 342


                 ....*....
gi 640683276 356 QRVQDKFSS 364
Cdd:cd03795  343 KRFEELFTA 351
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 203-325 1.29e-12

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 66.66  E-value: 1.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 203 LFASRMLWSKGLGDLIEAKKILEARNIHFTLNVAGILVENDKDAISLAVIQQWHKEGLINWLGHSSNVCDLIEESNIVAL 282
Cdd:cd01635  114 VSVGRLVPEKGIDLLLEALALLKARLPDLVLVLVGGGGEREEEEALAAALGLLERVVIIGGLVDDEVLELLLAAADVFVL 193

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 640683276 283 PSiYSEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGIIV 325
Cdd:cd01635  194 PS-RSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLLV 235
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 177-362 1.32e-12

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 68.25  E-value: 1.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 177 IVIDGAGINPEIYKYSLEQE-RDVPV-VLFASRMLWSKGLGDLIEAKKILEAR--NIHFTLNVAGILVENDKDAIslavi 252
Cdd:cd03799  150 IIVHRSGIDCNKFRFKPRYLpLDGKIrILTVGRLTEKKGLEYAIEAVAKLAQKypNIEYQIIGDGDLKEQLQQLI----- 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 253 QQWHKEGLINWLG--HSSNVCDLIEESNIVALPSIYS-----EGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGIIV 325
Cdd:cd03799  225 QELNIGDCVKLLGwkPQEEIIEILDEADIFIAPSVTAadgdqDGPPNTLKEAMAMGLPVISTEHGGIPELVEDGVSGFLV 304

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 640683276 326 KSNSPQELADKLEFLLANPKARVEMGIKGRQRVQDKF 362
Cdd:cd03799  305 PERDAEAIAEKLTYLIEHPAIWPEMGKAGRARVEEEY 341
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 193-363 1.29e-11

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 65.34  E-value: 1.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 193 LEQERDVPVVLFASRMLWSKGLGDLIEA-KKILEARNIHFTLNVAGILVEN-DKDAISLAVIQQWHK-EGLINWLGH--S 267
Cdd:cd03800  214 LLLPPDKPVVLALGRLDPRKGIDTLVRAfAQLPELRELANLVLVGGPSDDPlSMDREELAELAEELGlIDRVRFPGRvsR 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 268 SNVCDLIEESNIVALPSiYSEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGIIVKSNSPQELADKLEFLLANPKAR 347
Cdd:cd03800  294 DDLPELYRAADVFVVPS-LYEPFGLTAIEAMACGTPVVATAVGGLQDIVRDGRTGLLVDPHDPEALAAALRRLLDDPALW 372

                        170
                 ....*....|....*.
gi 640683276 348 VEMGIKGRQRVQDKFS 363
Cdd:cd03800  373 QRLSRAGLERARAHYT 388
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 22-363 5.25e-10

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 60.46  E-value: 5.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  22 WIDRAIAARDAGYEIHIIS-----HFVDGKVLNKFKTFGFKCHNVPLDAQSFNALTFfrAFFASRKLIKEI-NPDLLHCI 95
Cdd:cd03821   20 VLRLAAALAALGHEVTIVStgdgyESLVVEENGRYIPPQDGFASIPLLRQGAGRTDF--SPGLPNWLRRNLrEYDVVHIH 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  96 TI--KPCLIGGLLSRTNNRPVIVSfvGLGRVFSGDTGLLKLLRNITIMAYKYIASNKRSIFMFEHDKDRKKLAGFVgidY 173
Cdd:cd03821   98 GVwtYTSLAACKLARRRGIPYVVS--PHGMLDPWALQQKHWKKRIALHLIERRNLNNAALVHFTSEQEADELRRFG---L 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 174 QQTIVIDGAGINPEIYKYSLEQER------DVPVVLFASRMLWSKGLGDLIEA-KKILEARNiHFTLNVAGilvendKDA 246
Cdd:cd03821  173 EPPIAVIPNGVDIPEFDPGLRDRRkhngleDRRIILFLGRIHPKKGLDLLIRAaRKLAEQGR-DWHLVIAG------PDD 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 247 ISLAVIQQWHKEGLIN----WLGHSSNVcDLIE---ESNIVALPSiYSEGVPRILLEASSVGR-ACIAYDVGGCDslIIN 318
Cdd:cd03821  246 GAYPAFLQLQSSLGLGdrvtFTGPLYGE-AKWAlyaSADLFVLPS-YSENFGNVVAEALACGLpVVITDKCGLSE--LVE 321

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 640683276 319 NDNGIIVKSNsPQELADKL-EFL--LANPKARVEMGIKGRQRVQdKFS 363
Cdd:cd03821  322 AGCGVVVDPN-VSSLAEALaEALrdPADRKRLGEMARRARQVEE-NFS 367
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 188-362 6.29e-10

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 60.03  E-value: 6.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 188 IYKYSLEQERDVPVVLFASRMLWSKGLGDLIEAKKILEARNIHFTLNVAGILVENDKDAislAVI-------QQWHKEGL 260
Cdd:cd03792  186 YLEKPFVIDPERPYILQVARFDPSKDPLGVIDAYKLFKRRAEEPQLVICGHGAVDDPEG---SVVyeevmeyAGDDHDIH 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 261 INWLGHSSNVCDLIEESNIVALPSIYSEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGIIVksNSPQELADKLEFL 340
Cdd:cd03792  263 VLRLPPSDQEINALQRAATVVLQLSTREGFGLTVSEALWKGKPVIATPAGGIPLQVIDGETGFLV--NSVEGAAVRILRL 340

                        170       180
                 ....*....|....*....|..
gi 640683276 341 LANPKARVEMGIKGRQRVQDKF 362
Cdd:cd03792  341 LTDPELRRKMGLAAREHVRDNF 362
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 81-358 1.02e-09

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 59.26  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  81 RKLIKEINPDLLHcitikpcliggllsrTNNrpvivsFVGLGrvfsgdTGLLKLLRNITIMA------YKYIASNKrsiF 154
Cdd:cd03823   89 ARLLEDFRPDVVH---------------THN------LSGLG------ASLLDAARDLGIPVvhtlhdYWLLCPRQ---F 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 155 MFEHDKDR--------KKLAGFVGIDYQQTIVIDGaGINPEIYKysleQERDVP-----VVLFASRMLWSKGLGDLIEAK 221
Cdd:cd03823  139 LFKKGGDAvlapsrftANLHEANGLFSARISVIPN-AVEPDLAP----PPRRRPgterlRFGYIGRLTEEKGIDLLVEAF 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 222 KILEARNIHFTlnVAGILVENDkdaislavIQQWHKEGLINWLG--HSSNVCDLIEESNIVALPSIYSEGVPRILLEASS 299
Cdd:cd03823  214 KRLPREDIELV--IAGHGPLSD--------ERQIEGGRRIAFLGrvPTDDIKDFYEKIDVLVVPSIWPEPFGLVVREAIA 283

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 640683276 300 VGRACIAYDVGGCDSLIINNDNGIIVKSNSPQELADKLEFLLANPKARVEMGIKGRQRV 358
Cdd:cd03823  284 AGLPVIASDLGGIAELIQPGVNGLLFAPGDAEDLAAAMRRLLTDPALLERLRAGAEPPR 342
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 145-370 2.24e-09

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 58.08  E-value: 2.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 145 YIASNKRSIFMFEHDK---------DRKKLAGFVGIDYQQTIVIDGAGINPEIYKYSLEQERDVPVVLFASRMLWSKGLG 215
Cdd:cd04949   97 HSLIKNFYKYVFENLNkydaiivstEQQKQDLSERFNKYPPIFTIPVGYVDQLDTAESNHERKSNKIITISRLAPEKQLD 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 216 DLIEAKKILEARNIHFTLNVAGILVENDKDAislAVIQQWHKEGLINWLGHSSNVCDLIEESNIVALPSIYsEGVPRILL 295
Cdd:cd04949  177 HLIEAVAKAVKKVPEITLDIYGYGEEREKLK---KLIEELHLEDNVFLKGYHSNLDQEYQDAYLSLLTSQM-EGFGLTLM 252

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640683276 296 EASSVGRACIAYDVG-GCDSLIINNDNGIIVKSNSPQELADKLEFLLANPKARVEMGIKGRQrVQDKFSSGMIISK 370
Cdd:cd04949  253 EAIGHGLPVVSYDVKyGPSELIEDGENGYLIEKNNIDALADKIIELLNDPEKLQQFSEESYK-IAEKYSTENVMEK 327
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 25-363 7.04e-09

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 56.99  E-value: 7.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  25 RAIAARDAGYEIHIISHFVDGKVLNKFKTFGFKCHNVPLDAQSFNALTFFRAFFasrkLIKEINPDLLHCitikPCLIGG 104
Cdd:cd03809   25 KALAKNDPDESVLAVPPLPGELLRLLREYPELSLGVIKIKLWRELALLRWLQIL----LPKKDKPDLLHS----PHNTAP 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 105 LLSRtnNRPVIV-----------SFVGLGRVFSGDTGLLKLLRNitimAyKYIASNKRSIfmfehdkdRKKLAGFVGIDY 173
Cdd:cd03809   97 LLLK--GCPQVVtihdliplrypEFFPKRFRLYYRLLLPISLRR----A-DAIITVSEAT--------RDDIIKFYGVPP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 174 QQTIVIdGAGINPEIYKYSLEQER------DVPVVLFASRMLWSKGLGDLIEAKKILEARNIHFTLNVAGILveNDKDAI 247
Cdd:cd03809  162 EKIVVI-PLGVDPSFFPPESAAVLiakyllPEPYFLYVGTLEPRKNHERLLKAFALLKKQGGDLKLVIVGGK--GWEDEE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 248 SLAVIQQWHKEGLINWLGHSSN--VCDLIEESNIVALPSIYsEGVPRILLEASSVGRACIAYDVGgcdSL-IINNDNGII 324
Cdd:cd03809  239 LLDLVKKLGLGGRVRFLGYVSDedLPALYRGARAFVFPSLY-EGFGLPVLEAMACGTPVIASNIS---VLpEVAGDAALY 314

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 640683276 325 VKSNSPQELADKLEFLLANPKARVEMGIKGRQRVQdKFS 363
Cdd:cd03809  315 FDPLDPESIADAILRLLEDPSLREELIRKGLERAK-KFS 352
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 183-375 1.26e-08

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 55.91  E-value: 1.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 183 GINPEIYKYSLEQ----------ERDVPVVLFASRMLWSKGLGDLIEAKKILEARNIHFTLNVAGilvENDKDAISLAVI 252
Cdd:cd04951  162 GIDLNKFKKDINVrlkirnklnlKNDEFVILNVGRLTEAKDYPNLLLAISELILSKNDFKLLIAG---DGPLRNELERLI 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 253 QQWHKEGLINWLGHSSNVCDLIEESNIVALPSIYsEGVPRILLEASSVGRACIAYDVGGCDSlIINNDNGIIVKSNsPQE 332
Cdd:cd04951  239 CNLNLVDRVILLGQISNISEYYNAADLFVLSSEW-EGFGLVVAEAMACERPVVATDAGGVAE-VVGDHNYVVPVSD-PQL 315

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 640683276 333 LADKL-EFLLANPKARVEMGIKgRQRVQDKFSSGMIISKTLKTY 375
Cdd:cd04951  316 LAEKIkEIFDMSDEERDILGNK-NEYIAKNFSINTIVNEWERLY 358
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
279-363 2.73e-08

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 51.07  E-value: 2.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  279 IVALPSIYSEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGIIVKSnsPQELADKLEFLLANPKARVEMGIKGRQRV 358
Cdd:pfam13524   1 IVLNPSRRPDSPNMRVFEAAACGAPLLTDRTPGLEELFEPGEEILLYRD--PEELAEKIRYLLEHPEERRAIAAAGRERV 78


                  ....*
gi 640683276  359 QDKFS 363
Cdd:pfam13524  79 LAEHT 83
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 30-358 2.89e-07

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 51.90  E-value: 2.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  30 RDAGYEIHIISHFVDGK-------VLNKFKTFGFKCHNVPLdaqsfnaltFFRAFFASRKLIKEINPDLLHCITikPCLI 102
Cdd:cd03817   28 EKRGHEVYVITPSDPGAedeeevvRYRSFSIPIRKYHRQHI---------PFPFKKAVIDRIKELGPDIIHTHT--PFSL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 103 GGL---LSRTNNRPVIVSFVGLGRVFSGDTGLLKLLRNITIMAYKYIASNKRSIFMFEHDKDRKKLAGFvgiDYQQTIVI 179
Cdd:cd03817   97 GKLglrIARKLKIPIVHTYHTMYEDYLHYIPKGKLLVKAVVRKLVRRFYNHTDAVIAPSEKIKDTLREY---GVKGPIEV 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 180 DGAGINPEIY-KYSLEQER-------DVPVVLFASRMLWSKGLGDLIEA-KKILEARNIHFTLNVAGILVEN-DKDAISL 249
Cdd:cd03817  174 IPNGIDLDKFeKPLNTEERrklglppDEPILLYVGRLAKEKNIDFLLRAfAELKKEPNIKLVIVGDGPEREElKELAREL 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 250 AVIQQWHKEGLINWlghsSNVCDLIEESNIVALPSIySEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGIIVKSNS 329
Cdd:cd03817  254 GLADKVIFTGFVPR----EELPEYYKAADLFVFAST-TETQGLVYLEAMAAGLPVVAAKDPAASELVEDGENGFLFEPND 328

                        330       340
                 ....*....|....*....|....*....
gi 640683276 330 PqELADKLEFLLANPKARVEMGIKGRQRV 358
Cdd:cd03817  329 E-TLAEKLLHLRENLELLRKLSKNAEISA 356
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 287-364 2.55e-06

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 49.00  E-value: 2.55e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 640683276 287 SEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGIIVKSN-SPQELADKLEFLLANPKARVEMGIKGRQRVQDKFSS 364
Cdd:cd04946  314 SEGIPVSIMEAISFGIPVIATNVGGTREIVENETNGLLLDKDpTPNEIVSSIMKFYLDGGDYKTMKISARECWEERFNA 392
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 293-361 1.13e-05

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 46.90  E-value: 1.13e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 640683276 293 ILLEASSVGRACIAYDVGGCDSLIINNDNGIIVKSNSPQELADKLEFLLANPKARVEMGIKGRQRVQDK 361
Cdd:cd03814  283 VVLEAMASGLPVVAADAGGPRDIVRPGGTGALVEPGDAAAFAAALRALLEDPELRRRMAARARAEAERY 351
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
 290-363 6.41e-05

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 44.50  E-value: 6.41e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 640683276 290 VPrilLEASSVGRACIAYDVGG-CDSlIINNDNGIIVKSNsPQELADKLEFLLANPKARVEMGIKGRQRVQDKFS 363
Cdd:cd03805  315 VP---LEAMYAGKPVIACNSGGpLET-VVEGVTGFLCEPT-PEAFAEAMLKLANDPDLADRMGAAGRKRVKEKFS 384
PelF NF038011
GT4 family glycosyltransferase PelF; Proteins of this family are components of the ...
 269-349 1.86e-04

GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter.


Pssm-ID: 411604 [Multi-domain]  Cd Length: 489  Bit Score: 43.38  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 269 NVCDLIEESNIVALPSIySEGVPRILLEASSVGRACIAYDVGGCDSLIINNDN--------GIIVKSNSPQELADKLEFL 340
Cdd:NF038011 376 KIDDLLPQVGLMVLSSI-SEALPLVVLEAFAAGVPVVTTDVGSCRQLIEGLDEedralgaaGEVVAIADPQALARAALDL 454

                         90
                 ....*....|....*....
gi 640683276 341 LANPK----------ARVE 349
Cdd:NF038011 455 LRDPQrwqaaqaaglARVE 473
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
26-179 3.45e-04

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 40.98  E-value: 3.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276   26 AIAARDAGYEIHIISHFVDGKVLNKFKTF-GFKCHNVPLDAQSFNALTFFRAFfasRKLIKEINPDLLHCITIKPCLIGG 104
Cdd:pfam13439  11 ARALARRGHEVTVVTPGGPGPLAEEVVRVvRVPRVPLPLPPRLLRSLAFLRRL---RRLLRRERPDVVHAHSPFPLGLAA 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640683276  105 L-LSRTNNRPVIVSFVGLGRVFSGDTGLLKLLRNITIMAYKYIAsNKRSIFMFEHDKDRKKLAGFVGIDYQQTIVI 179
Cdd:pfam13439  88 LaARLRLGIPLVVTYHGLFPDYKRLGARLSPLRRLLRRLERRLL-RRADRVIAVSEAVADELRRLYGVPPEKIRVI 162
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 34-323 4.00e-04

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 41.89  E-value: 4.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276  34 YEIHIISHF-VDGKVLNKFKTFGFKCHNVPldAQSFNALTFFRAFFasrKLIKEINPDLLHCITIKPCLIGGLLSRTNNR 112
Cdd:cd03812   30 IEFDFLATSdDKGEYDEELEELGGKIFYIP--PKKKNIIKYFIKLL---KLIKKEKYDIVHVHGSSSNGIILLLAAKAGV 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 113 PVIV-----SFVGLGRVFSGDTGLLKLLrnITIMAYKYIA-SNKRSIFMFehdkdrkklaGFVGIDYQQTIvidGAGINP 186
Cdd:cd03812  105 PVRIahshnTKDSSIKLRKIRKNVLKKL--IERLSTKYLAcSEDAGEWLF----------GEVENGKFKVI---PNGIDI 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 187 EIYKYSLEQERDVPVVLFASRMLWSKGLGDLIEAKkilearNIHFTLNVAGILVENDKDAISLAV---------IQQWHK 257
Cdd:cd03812  170 EKYKFNKEKRRKRRKLLILEDKLVLGHVGRFNEQK------NHSFLIDIFEELKKKNPNVKLVLVgegelkekiKEKVKE 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 640683276 258 EGL---INWLGHSSNVCDLIEESNIVALPSIYsEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGI 323
Cdd:cd03812  244 LGLedkVIFLGFRNDVSEILSAMDVFLFPSLY-EGLPLVAVEAQASGLPCLLSDTITKECDITNNVEFL 311
GT4_mannosyltransferase-like cd03822
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most ...
 212-350 1.18e-03

mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.


Pssm-ID: 340849 [Multi-domain]  Cd Length: 370  Bit Score: 40.45  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 212 KGLGDLIEAKKILEARNIHFTLNVAGILVEN---------DKDAISLAVIQ---QWHKEGLINwlghsSNVCDLIEESNI 279
Cdd:cd03822  200 KGLEILLEALPELKAEFPDVRLVIAGELHPSlaryegeryRKAAIEELGLQdhvDFHNNFLPE-----EEVPRYISAADV 274

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640683276 280 VALPsiY---SEGVPRILLEASSVGRACIAYDVGGCDSLIInNDNGIIVKSNSPQELADKLEFLLANPKARVEM 350
Cdd:cd03822  275 VVLP--YlntEQSSSGTLSYAIACGKPVISTPLRHAEELLA-DGRGVLVPFDDPSAIAEAILRLLEDDERRQAI 345
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 264-378 1.97e-03

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 40.03  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 264 LGHSSNVCDLIEESNIVALPSiYSEGVPRILLEASSVGRACIAYDVGGCDSLIINNDNGIIVKSNSPQELADKLEFLLAN 343
Cdd:cd04962  257 LGKQDDVEELLSIADLFLLPS-EKESFGLAALEAMACGVPVVSSNAGGIPEVVKHGETGFLSDVGDVDAMAKSALSILED 335

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 640683276 344 PKARVEMGIKGRQRVQDKFSSGMIISKTLKTYHDV 378
Cdd:cd04962  336 DELYNRMGRAARKRAAERFDPERIVPQYEAYYRRL 370
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
 294-365 4.60e-03

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 38.88  E-value: 4.60e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 640683276 294 LLEASSVGRACIAYDVGGCDSLIINNDNGIIVKSNSPQELADKLEFLLANPKARVEMGIKGRQRVQDKFSSG 365
Cdd:cd03818  317 LLEAMACGCPVIGSDTAPVREVIRDGRNGLLVDFFDPDALAAAVLELLEDPDRAAALRRAARRTVERSDSLD 388
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
194-337 5.83e-03

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 38.54  E-value: 5.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640683276 194 EQERDVP-VVLFASRMLW--SKGLGDLIEAkkiLEARNIHFTLNVAGilvENDKDAISLAVIQQWHKEGLINWLGHSSN- 269
Cdd:PRK09922 174 PPERDKPaVFLYVGRLKFegQKNVKELFDG---LSQTTGEWQLHIIG---DGSDFEKCKAYSRELGIEQRIIWHGWQSQp 247

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 640683276 270 ---VCDLIEESNIVALPSIYsEGVPRILLEASSVGRACIAYD-VGGCDSLIINNDNGIIVKSNSPQELADKL 337
Cdd:PRK09922 248 wevVQQKIKNVSALLLTSKF-EGFPMTLLEAMSYGIPCISSDcMSGPRDIIKPGLNGELYTPGNIDEFVGKL 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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