|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
10-499 |
0e+00 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 1008.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 10 ITLRDVTIIDDAKLRKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSLQMIAALGTFSVPFLIRPLGGLFFGML 89
Cdd:PRK10642 1 ITLRDVTIIDDGKLRKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGML 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 90 GDKYGRQKILAITIVIMSISTFCIGLIPSYATIGIWAPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLD 169
Cdd:PRK10642 81 GDKYGRQKILAITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 170 FGSIAGFVMGAGVVVLISTVVGEDNFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVEKLEQGDREGLQDGPKVS 249
Cdd:PRK10642 161 FGSIAGFVLGAGVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQHVDKLEQGDREGLQDGPKVS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 250 FKEIATKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFII 329
Cdd:PRK10642 241 FKEIATKHWRSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 330 LGSVALFALAIPAFILINSDVLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNISVLIAGLTPTLAAS 409
Cdd:PRK10642 321 LGSVALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAW 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 410 LVESTQNLMMPAYYLMVIAVIGLITGLTMKETANRPLKGATPAASDIQEAKEILREHYDNVEQKIEDIDAEIEELQKKRS 489
Cdd:PRK10642 401 LVESTQNLMMPAYYLMVVAVIGLITGVTMKETANRPLKGATPAASDIQEAKEILVEHYDNIEQKIDDIDQEIAELQAKRT 480
|
490
....*....|
gi 658547747 490 RLVDQHPRIN 499
Cdd:PRK10642 481 RLVQQHPRID 490
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
27-442 |
0e+00 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 587.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 27 ITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSLQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIM 106
Cdd:cd17366 1 VKAAALGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 107 SISTFCIGLIPSYATIGIWAPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLI 186
Cdd:cd17366 81 AASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 187 STVVGEDNFLDWGWRIPFFLALPLGIIGLYLRhaleetpafqqhvekleqgdreglqdgpkvsfkeiatkhwRSLLTCIG 266
Cdd:cd17366 161 TLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLR----------------------------------------RPLLICIG 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 267 LVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSVALFALAIPAFILI 346
Cdd:cd17366 201 LVLVFNVTNYMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLM 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 347 NSDVLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNISVLIAGLTPTLAAS-LVESTQNLMMPAYYLM 425
Cdd:cd17366 281 NSGSIAAIFIGLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASwLVSATGNPLMPAYYLM 360
|
410
....*....|....*..
gi 658547747 426 VIAVIGLITGLTMKETA 442
Cdd:cd17366 361 VAAVVGLVAVLFLTETA 377
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
33-432 |
2.16e-162 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 465.59 E-value: 2.16e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 33 GNAMEWFDFGVYGFVAYALGKVFFPGA-DPSLQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTF 111
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSgDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 112 CIGLIPSYATIGIWAPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISTVVG 191
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 192 EDNFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVEKLEQgdreglqdgPKVSFKEIATKHWRSLLTCIGLVIST 271
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKK---------KRGPIAETLTKHRKPFLLGLGLVIAT 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 272 NVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSVALFALAIPAF-ILINSDV 350
Cdd:TIGR00883 232 TTTFYLITTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLmALLDSGS 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 351 LGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNISVLI-AGLTPTLAASLVESTQNLMMPAYYLMVIAV 429
Cdd:TIGR00883 312 FTLFFFLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIfGGFAPYIAAALVAMTGDWYAIGYYLAALAL 391
|
...
gi 658547747 430 IGL 432
Cdd:TIGR00883 392 IGL 394
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
24-437 |
6.04e-135 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 396.13 E-value: 6.04e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 24 RKAITAASLGNAMEWFDFGVYGFVAyAL--GKVFFPGADPSLQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAI 101
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAA-ALvfNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 102 TIVIMSISTFCIGLIPSYATIGIWAPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAG 181
Cdd:cd17369 80 TLLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 182 VVVLISTVVGEDNFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVEKLEQgdreglqdgPKVSFKEIATKHWRSL 261
Cdd:cd17369 160 VFLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQV---------VRAPLVEVLRRHWRAL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 262 LTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSVALFALAIP 341
Cdd:cd17369 231 LLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFP 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 342 AFILINS-DVLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNI-SVLIAGLTPTLAASLVESTQNLMM 419
Cdd:cd17369 311 FFWLLDTgSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLgAILGGGFAPLIATALVAATGSWWP 390
|
410
....*....|....*...
gi 658547747 420 PAYYLMVIAVIGLITGLT 437
Cdd:cd17369 391 VALYLAALAVISLVAALF 408
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
27-442 |
5.14e-101 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 309.23 E-value: 5.14e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 27 ITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSLQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIM 106
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 107 SISTFCIGLIPSYATIGIWAPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLI 186
Cdd:cd17367 81 AAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 187 STVVGEDNFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVEKLEQgdreglqdgPKVSFKEIAtKHWRSLLTCIG 266
Cdd:cd17367 161 QHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEA---------SAGTLRELR-RHPRELLLVVG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 267 LVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSVALFALAIPAFILI 346
Cdd:cd17367 231 LTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSAL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 347 -NSDVLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNISVLIAGLT-PTLAASLVestQNLMMPAY-- 422
Cdd:cd17367 311 dHTDSPYTAFALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTaPYVALWLK---SIGHEWVFfw 387
|
410 420
....*....|....*....|
gi 658547747 423 YLMVIAVIGLITGLTMKETA 442
Cdd:cd17367 388 YVAGLIAISLVVYLRMPETR 407
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
27-442 |
1.23e-98 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 303.14 E-value: 1.23e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 27 ITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSLQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIM 106
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 107 SISTFCIGLIPSYATIGIWAPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLI 186
Cdd:cd17368 81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 187 STVVGEDNFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVEKLEqgdreglqdgpKVSFKEIATKHWRSLLTCIG 266
Cdd:cd17368 161 SLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPT-----------RRELFALLANNRRIILLGML 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 267 LVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSVALFALAIPAF-IL 345
Cdd:cd17368 230 LVAGSTVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFaWL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 346 INSDVLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNISVLI-AGLTPTLAASLVESTQNLMMPAYYL 424
Cdd:cd17368 310 TAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIfGGFAQFIVTWLIELTGSPLAPAWYL 389
|
410
....*....|....*...
gi 658547747 425 MVIAVIGLITGLTMKETA 442
Cdd:cd17368 390 MGAALLGLLATLMLRETA 407
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
27-436 |
1.59e-85 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 267.55 E-value: 1.59e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 27 ITAASLGNAMEWFDFGVYGFVAYALGKVFfpgaDPSLQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIM 106
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 107 SISTFCIGLIPSyatigiwaPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLI 186
Cdd:cd17316 77 GLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 187 STVVGEdnflDWGWRIPFFLALPLGIIGLYLRhaleetpafqqhvekleqgdreglqdgpkvsfkeiatkhwRSLLTCIG 266
Cdd:cd17316 149 IPLLSG----DWGWRILFLIGALPALLALLLR----------------------------------------RRTLLLIL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 267 LVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSVALFALAIPAFILI 346
Cdd:cd17316 185 LWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 347 NSDVLgLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNISVLIAGLTPTLAASLVESTQNLMMPAYYLMV 426
Cdd:cd17316 265 SGSPT-LLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILAL 343
|
410
....*....|
gi 658547747 427 IAVIGLITGL 436
Cdd:cd17316 344 LAIVALIVAL 353
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
25-453 |
8.01e-83 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 263.34 E-value: 8.01e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 25 KAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSLQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIV 104
Cdd:PRK15075 15 RAILRVTSGNFLEMFDFFLFGFYATAIAKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 105 IMSISTFCIGLIPSYATIGIWAPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVV 184
Cdd:PRK15075 95 IMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLGY 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 185 LISTVVGEDNFLDWGWRIPFF---LALPLgiiGLYLRHALEETPAFQQHVEKLeqgdreglqdgpkvSFKEIAT---KHW 258
Cdd:PRK15075 175 LLNQWLSPAQMAEWGWRIPFLigcLIVPF---IFLIRRSLEETEEFLARKHRP--------------SMREIFRslaANW 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 259 RSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSVALFAL 338
Cdd:PRK15075 238 RIVLAGMLMVAMTTVSFYLITVYTPTFGKTVLHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVLIAFTVLAILT 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 339 AIPAFI-LINSDVLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNISVLI-AGLTPTLAASLVESTQN 416
Cdd:PRK15075 318 AYPALSwLVAAPSFARMLAVELWLSFLYGSYNGAMVVALTEVMPAEVRTAGFSLAYSLATAIfGGFTPAISTWLIHVTGD 397
|
410 420 430
....*....|....*....|....*....|....*..
gi 658547747 417 LMMPAYYLMVIAVIGLITGLTMKETANRPLKGATPAA 453
Cdd:PRK15075 398 KAAPGYWLSFAAVCGLIATLVLYRRRGARLQAAEAAA 434
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
30-447 |
9.22e-79 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 253.35 E-value: 9.22e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 30 ASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSLQMIAALG-----TFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIV 104
Cdd:pfam00083 5 AALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKSVSSLAALSvlsglIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 105 IMSISTFCIGLIPSYatigiWAPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVV 184
Cdd:pfam00083 85 LFVIGAVLQGAAKGK-----WSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 185 LISTVVGEdnfldWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVEKLEQgDREGLQ-----DGPKVSFKEIATKHWR 259
Cdd:pfam00083 160 GLNKTSNS-----DGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEE-AREVLAklrgvPDVDRELDEIKDSLEA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 260 S--------------------LLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDhgvLIIIAIMVGMLFVQPIMGL-L 318
Cdd:pfam00083 234 GqeaekaswkelfstktrrqrLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDS---FLVTIIVGVVNFVFTFIAIfL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 319 SDRFGRRPFIILGSVALFA----LAIPAFILINSD---VLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAA 391
Cdd:pfam00083 311 VDRFGRRPLLLLGAAGMAIcfviLGIVALLGVSKSdwaGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMAL 390
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 658547747 392 AFNISVLIAGLTPTLAASLVESTQNLMMPAYYLMVIAVIGLITGLTMKETANRPLK 447
Cdd:pfam00083 391 ATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLE 446
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
24-441 |
8.46e-78 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 250.42 E-value: 8.46e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 24 RKAITAASLGNAMEWFDFGVYGFVAyAL--GKVFFPGADPSLQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAI 101
Cdd:PRK09952 21 RRAALGSFAGAVVDWYDFLLYGITA-ALvfNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRMLML 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 102 TIVIMSISTFCIGLIPSYATIGIWAPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAG 181
Cdd:PRK09952 100 TVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLSTG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 182 VVVLISTVVGEDNFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVEKLEQGDReglqdgpKVSFKEIATKHWRSL 261
Cdd:PRK09952 180 LVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQAAAKK-------RIPVIEALLRHPGAF 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 262 LTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDhgVLIIIAIMVGML--FVQPIMGLLSDRFGRRPFIILGSVALFALA 339
Cdd:PRK09952 253 LKIIALRLCELLTMYIVTAFALNYSTQNLGLPRE--LFLNIGLLVGGLscLTIPCFAWLADRFGRRRVYITGALIGTLSA 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 340 IPAFILINS-DVLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNI-SVLIAGLTPTLAASLVE-STQN 416
Cdd:PRK09952 331 FPFFMALEAqSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVaSVVGGGFTPFIAAALVTyFGGS 410
|
410 420
....*....|....*....|....*
gi 658547747 417 LMMPAYYLMVIAVIGLITGLTMKET 441
Cdd:PRK09952 411 WHSVAIYLLAGCLISAMTALLMKDN 435
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
26-385 |
4.75e-67 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 221.99 E-value: 4.75e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 26 AITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSLQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVI 105
Cdd:PRK10406 23 AIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLISVCM 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 106 MSISTFCIGLIPSYATIGIWAPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVL 185
Cdd:PRK10406 103 MCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVV 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 186 ISTVVGEDNFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVEKlEQGDREGLQdgpkvsfkeiatKHWRSLLTCI 265
Cdd:PRK10406 183 LQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDETSQQETRALK-EAGSLKGLW------------RNRRAFIMVL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 266 GLVISTNVTYYMLLTYMPSYL--SHNLHYSEDHGvLIIIAIMVGMLfVQPIMGLLSDRFGRR-PFIILGSVALFaLAIPA 342
Cdd:PRK10406 250 GFTAAGSLCFYTFTTYMQKYLvnTAGMHANVASG-IMTAALFVFML-IQPLIGALSDKIGRRtSMLCFGSLAAL-FTVPI 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 658547747 343 FILINSDVLGLIFAGLLMLAVILNCFIGVMASTLPA-MFPTHIR 385
Cdd:PRK10406 327 LSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAeMFPAQVR 370
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
29-433 |
9.76e-42 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 153.23 E-value: 9.76e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 29 AASLGNAMEWFDFGVYGFVAYALGKVFfpGADPSLQMIaalgTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSI 108
Cdd:cd17371 3 AAFLGWALDGFDLLLLGLVLPALIAEF--GLDEAEAGL----LGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 109 STFCIGLIPSYatigiwapILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDfgsiAGFVMGAGVVVLIST 188
Cdd:cd17371 77 FTLLCGFAQNY--------WQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQ----SGWAVGWLLATLLAA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 189 VVGEDNFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVEKLEQGDreglqdgPKVSFKEIATKHWRSL-LTCIGL 267
Cdd:cd17371 145 LLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFA-------DRPSLRELFSPPLLRTtLLASLL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 268 VISTNVTYYMLLTYMPSYLSHNLHYSeDHGVLIIIAIMV-GMLFVQPIMGLLSDRFGRRPFIILGSV--ALFALAIPAFI 344
Cdd:cd17371 218 ATGALGGYYGITTWLPSYLTGERGLS-FEGSAGYLVVTIlGGFLGYLAGGFLADRIGRRNNFALFALgsAISILLYFFLP 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 345 LINSDVLGLIFAGLLMLAVILncfiGVMASTLPAMFPTHIRYSALAAAFNISVLIAGLTPTLAASLVE--STQN---LMM 419
Cdd:cd17371 297 LSPTLILILGFPLGFFASGPF----SGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATsgSLGTaiaVFA 372
|
410
....*....|....
gi 658547747 420 PAYYLMVIAVIGLI 433
Cdd:cd17371 373 AVYYIAGLVLALLL 386
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
24-445 |
2.62e-39 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 146.95 E-value: 2.62e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 24 RKAITAASLGNAMEWFDFGVYGFVAYALGKVFfpGADPSLQMIAalgtFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 103
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEF--GLSAAQLGLL----FAIPVLVGALLRIPLGFLVDRFGPRRVLLIGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 104 VIMSISTFCIGLIPSYatigiwapILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLdfgsIAGFVMGAGVV 183
Cdd:COG2223 78 LLLGIGLLLLALAVSY--------WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLA----AGGGNLGAAVA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 184 VLISTVVgednFLDWGWRIPFFL-ALPLGIIGLYLRHALEETPAFQQHVEKleqgdreglqdGPKVSFKEIAtKHWRSLL 262
Cdd:COG2223 146 AFLAPLL----IAAFGWRNAFLIlGILLLVVAVLAWLFLRDPPAGAAAAAK-----------ASLRDQLEAL-RDPRFWL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 263 TCIGLVISTnVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRP-FIILGSVALFALAIP 341
Cdd:COG2223 210 LSLLYFGTF-GSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRvLLIVFALMALGLLLL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 342 AFILINsdvLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNISVLIAGLTPTLAASLVESTQNLMMPA 421
Cdd:COG2223 289 ALALGS---LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAF 365
|
410 420
....*....|....*....|....
gi 658547747 422 YYLMVIAVIGLITGLTMKETANRP 445
Cdd:COG2223 366 LVFAVLALVALVLTLLLYRRPRRA 389
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
24-402 |
1.29e-37 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 141.26 E-value: 1.29e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 24 RKAITAASLGNAMEWFDFGVYGFVAYALGKVFfpGADPSlqmiAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 103
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADL--GASPA----QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 104 VIMSISTFCIGLIPSYAtigiwapiLLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVV 183
Cdd:COG2814 83 LLFALGSLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 184 VLISTVvgednfldWGWRIPFFLALPLGIIGLYLRHALeetpafqqhVEKLEQGDREGLQDGPKVSFKeiatkhWRSLLT 263
Cdd:COG2814 155 GLLADL--------FGWRWVFLVNAVLALLALLLLLRL---------LPESRPAARARLRGSLRELLR------RPRLLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 264 CIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGsvaLFALAIPAF 343
Cdd:COG2814 212 LLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG---LLLLALGLL 288
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 658547747 344 ILINSDVLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNISVLIAGL 402
Cdd:COG2814 289 LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
24-444 |
1.77e-37 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 141.16 E-value: 1.77e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 24 RKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGAdpslqmiAALGT-FSVPFLIRPLGGLFFGMLGDKYGRQKILAIT 102
Cdd:COG2271 9 WRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSA-------AQLGLlASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 103 IVIMSISTFCIGLIPSYAtigiwapiLLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGV 182
Cdd:COG2271 82 LLLWGLATLLFGFATSFW--------QLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 183 VVLISTVvgednfldWGWRIPFFLALPLGIIGLYLRhaleetpafqqhvekleqgdreglqdgpkvsfkeiatkhwrsLL 262
Cdd:COG2271 154 LGWLLAA--------FGWRAAFLILGLPGLLLALLR------------------------------------------FW 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 263 TCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGsVALFALAIPA 342
Cdd:COG2271 184 LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLA-IGLLLAALAL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 343 FILINSDVLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNISVLIAGLTPTLAASLVESTqNLMMPAY 422
Cdd:COG2271 263 LLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFL 341
|
410 420
....*....|....*....|..
gi 658547747 423 YLMVIAVIGLITGLTMKETANR 444
Cdd:COG2271 342 LLAALALLAALLALLLLRETRK 363
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
24-330 |
2.50e-32 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 125.31 E-value: 2.50e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 24 RKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGAdPSLQMIAALGtfsvpFLIRPLGGLFFGMLGDKYGRQKILAITI 103
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASS-AQLGWIVSAY-----LLGRAIGLLLFGRLGDRYGRKRVLLIGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 104 VIMSISTFCIGLIPSyatigiwaPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVV 183
Cdd:COG0477 87 LLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 184 VLISTVvgednfldWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVEKLEQGDREGLQDGPKVSFKEIATkhWRSLLT 263
Cdd:COG0477 159 GLLVAA--------LGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLL--LLLLLA 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658547747 264 CIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIIL 330
Cdd:COG0477 229 LLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
72-433 |
5.06e-26 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 109.20 E-value: 5.06e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 72 FSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLICKMAQGFSVGGEYTGASIF 151
Cdd:cd17325 37 VAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW--------QLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 152 VAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISTVvgednfldWGWRIPFFLALPLGIIGLYLRHA-LEETPAFQQH 230
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA--------LGYRAPFLVCAALALLALVLALLlLPEPRPPPNK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 231 VEKLEQGDREGLqdgpkvsfkeIATKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLF 310
Cdd:cd17325 181 RAVSAARLRSGL----------RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 311 VQPIMGLLSDRFGRRPFIILGSVaLFALAIPAFILINSDVLgliFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALA 390
Cdd:cd17325 251 SQPPAGKLSDRIGRKPLILIGLL-LSAVALLLLPLATSFWL---LLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAM 326
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 658547747 391 AAFNISVLIAGLTPTLAASLVESTQNLMMPAYYLMVIAVIGLI 433
Cdd:cd17325 327 GLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAV 369
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
24-414 |
5.10e-25 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 107.86 E-value: 5.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 24 RKAITAASLGNAMEWFDFGVYGFVAYALGKVFfpgadpSLQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 103
Cdd:PRK03893 19 WKAFSAAWLGYLLDGFDFVLITLVLTEVQGEF------GLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 104 VIMSISTFCIGLIPSYATigiwapilLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLdfgsIAGFVMGAGVV 183
Cdd:PRK03893 93 VLFSVGTLACGFAPGYWT--------LFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFL----ISGFSIGAVVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 184 VLISTVVGEdnflDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVEK----------LEQGDR-------------- 239
Cdd:PRK03893 161 AQVYSLVVP----VWGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGkapvrtmvdiLYRGEHriinilltlaaaaa 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 240 ------EGLQDGPKV------------SF-KEIATKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLI 300
Cdd:PRK03893 237 lwfcfaGNLQNAAIVavlgllcaaifiSFmVQSSGKRWPTGVMLMVVVLFAFLYSWPIQALLPTYLKTDLGYDPHTVANV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 301 IIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSVALFALAIPAFILINSDVLGLifAGLLMLAVILNCFI-GVMASTLPAM 379
Cdd:PRK03893 317 LFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLISQLLIIPVFAIGGANVWVL--GLLLFFQQMLGQGIsGLLPKLIGGY 394
|
410 420 430
....*....|....*....|....*....|....*
gi 658547747 380 FPTHIRYSALAAAFNISVLIAGLTPTLAASLVEST 414
Cdd:PRK03893 395 FDTEQRAAGLGFTYNVGALGGALAPILGALIAQRL 429
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
17-411 |
6.40e-25 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 106.29 E-value: 6.40e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 17 IIDDAKLR----KAITAASLGNAMEWFDFGVYGFVAYALGKVFfpGADP-SLQMIAALGTFSVPFlirplGGLFFGMLGD 91
Cdd:TIGR00895 5 NIRKQPLSryqwRAIILSFLIMLMDGYDLAAMGFAAPAISAEW--GLDPvQLGFLFSAGLIGMAF-----GALFFGPLAD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 92 KYGRQKILAITIVIMSISTFCIGLIPSYatigiwapILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLdfg 171
Cdd:TIGR00895 78 RIGRRRVLLWSILLFSVFTLLCALATNV--------TQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLM--- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 172 sIAGFVMGAGVVVLISTVVGEdnflDWGWRIPFFLA--LPLgIIGLYLRHALEETPAFQqhVEKLEQGDREGL------- 242
Cdd:TIGR00895 147 -FCGYPIGAAVGGFLAGWLIP----VFGWRSLFYVGgiAPL-LLLLLLMRFLPESIDFL--VSKRPETVRRIVnaiapqm 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 243 --------------QDGPKVSFKEI-ATKHWRSLLTCIGLVISTNVTYYMLLTYMPsYLSHNLHYSEDHGVLIIIAIMVG 307
Cdd:TIGR00895 219 qaeaqsalpeqkstQGTKRSVFKALfQGKTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFG 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 308 MLFVQPIMGLLSDRFGRRPfiilgsVALFALAIPAFILINSDVLGlIFAGLLMLAVILNCF----IGVMASTLPAMFPTH 383
Cdd:TIGR00895 298 GVIGSIIFGWLADRLGPRV------TALLLLLGAVFAVLVGSTLF-SPTLLLLLGAIAGFFvnggQSGLYALMALFYPTA 370
|
410 420
....*....|....*....|....*...
gi 658547747 384 IRYSALAAAFNISVLIAGLTPTLAASLV 411
Cdd:TIGR00895 371 IRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
72-404 |
1.72e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 104.42 E-value: 1.72e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 72 FSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLICKMAQGFSVGGEYTGASIF 151
Cdd:pfam07690 38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW--------LLLVLRVLQGLGAGALFPAALAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 152 VAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISTVvgednfldWGWRIPFFLALPLGIIGLYLRHALEETPafqqhv 231
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL--------FGWRAAFLILAILSLLAAVLLLLPRPPP------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 232 EKLEQGDREGLQDGPKVSFKEIATKHWRSLLTCIglvISTNVTYYMLLTYMPSYLSHnLHYSEDHGVLIIIAIMVGMLFV 311
Cdd:pfam07690 176 ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL---LLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 312 QPIMGLLSDRFGRRPFIILGSVALFALAIPAFILINSDVLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAA 391
Cdd:pfam07690 252 RLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGL 331
|
330
....*....|...
gi 658547747 392 AFNISVLIAGLTP 404
Cdd:pfam07690 332 YNTAGSLGGALGP 344
|
|
| Osmo_CC |
pfam08946 |
Osmosensory transporter coiled coil; The osmosensory transporter coiled coil is a C-terminal ... |
454-498 |
3.98e-24 |
|
Osmosensory transporter coiled coil; The osmosensory transporter coiled coil is a C-terminal domain found in various bacterial osmoprotective transporters, such as ProP, Proline/betaine transporter, Proline permease 2 and the citrate proton symporters. It adopts an antiparallel coiled-coil structure, and is essential for osmosensory and osmoprotectant transporter function.
Pssm-ID: 430338 Cd Length: 45 Bit Score: 94.75 E-value: 3.98e-24
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 658547747 454 SDIQEAKEILREHYDNVEQKIEDIDAEIEELQKKRSRLVDQHPRI 498
Cdd:pfam08946 1 SDRQEAKELLQEHYDNIEQKIEDIDEEIAALEEKRQRLVDQHPHI 45
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
24-438 |
1.99e-20 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 93.45 E-value: 1.99e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 24 RKAITAASLGNAMEWFDFGVYGFVAYALGkvffpgADPSLQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 103
Cdd:PRK12307 17 KNALFSAWLGYVFDGFDFMLIFYIMYLIK------ADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 104 VIMSISTFCIGLIPSYatigiwapILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLdfgsIAGFVMGAGVV 183
Cdd:PRK12307 91 VAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFL----VSGFGIGNIIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 184 VLISTVVGEdnflDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVEKLEQGDREGLQDGPKVSFKEIATKHWRSLLT 263
Cdd:PRK12307 159 AYFMPSFAE----AYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSLSMKGLFNRAQFPLTL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 264 CIGLVI-STNVTYYMLLTYMPSYLSHNlhySEDHGVL--IIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSVALFALAI 340
Cdd:PRK12307 235 CVFIVLfSIFGANWPIFGLLPTYLAGE---GFDTGVVsnLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIF 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 341 PAFILI--NSDVLGLIFAGLLMLAVILNcfiGVMASTLPAMFPTHIRYSALAAAFNISVlIAGLTPTLAASLVESTQNLM 418
Cdd:PRK12307 312 PLFRIPqdNYLLLGACLFGLMATNVGVG---GLVPKFLYDYFPLEVRGLGTGLIYNLAA-TSGTFNSMAATWLGITMGLG 387
|
410 420
....*....|....*....|..
gi 658547747 419 MPAYYLMVI--AVIGLITGLTM 438
Cdd:PRK12307 388 AALTFIVAFwtATILLIIGLSI 409
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-433 |
9.06e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 87.87 E-value: 9.06e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 30 ASLGNAMEWFDFGVYGFVAYALGKVFfpGADPSLQMIAalgtFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSIS 109
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSF--GLSASQLGLL----FALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 110 TFCIGLIPSYatigiwapILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISTv 189
Cdd:cd06174 75 ALLFAFAPSF--------WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 190 vgednFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQhvekleqgdREGLQDGPKVSFKEIATKHWRSLLTCIGLVI 269
Cdd:cd06174 146 -----SLGFGWRAVFLIAAALALLAAILLLLVVPDPPESA---------RAKNEEASSKSVLKLLKRVLKNPGLWLLLLA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 270 S--TNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSVALFALAIpaFILIN 347
Cdd:cd06174 212 IflVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGL--ALLLL 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 348 SDVLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNISVLIAGLTPTLAASLVESTQNLMMPAYYLMVI 427
Cdd:cd06174 290 APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVL 369
|
....*.
gi 658547747 428 AVIGLI 433
Cdd:cd06174 370 LLLAAI 375
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
64-438 |
1.01e-17 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 84.54 E-value: 1.01e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 64 QMIAALGTFSVPFLIrplGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLICKMAQGFSVGG 143
Cdd:cd17319 39 QYGLIASAFFLGYAL---FQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTS--------LYVLRFLLGVAEAG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 144 EYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISTVvgednfldWGWRIPFFLalpLGIIGLYLRHALee 223
Cdd:cd17319 108 FFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLL--------FGWRWAFII---EGLLGLLLAVLW-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 224 tpafqqhvekleqgdreglqdgpkvsfkeiatkhWRSLLTCIGLVIS---TNVTYYMLLTYMPSYLSHNLHYSEDHGVLI 300
Cdd:cd17319 175 ----------------------------------WFYLRQVWGLALGyfgINYALYGLLTWLPTYLKQARGFSLKQVGLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 301 IIAIMVGMLFVQPIMGLLSDRF--GRRPFIILGSVALFALAIPAFILINSDVLGLIFagLLMLAVILNCFIGVMASTLPA 378
Cdd:cd17319 221 AAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVIL--LSLAGFGIGAASPVFWSLPAD 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 379 MFPTHIRYSALAAAFNISVLIAGLTPTLAASLVESTQNLMMPAYYLMVIAVIGLITGLTM 438
Cdd:cd17319 299 LLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
81-436 |
1.65e-17 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 84.14 E-value: 1.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLICKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 161 RGF-MGSWldfgsIAGFVMGAGVVVLISTVVGEDnfldWGWRIPFFLALPLGIIG-LYLRHALEETPAFQqhvekleqgd 238
Cdd:cd17324 121 RGRaIGLV-----FSGLTLGLVLGRPLGGLLGQL----LGWRAAFLAIAVLALLAaLLLWRLLPSLPPKK---------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 239 reglqDGPKVSFKEIAtKHWRS--LLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMG 316
Cdd:cd17324 182 -----PGSLGLLSSLL-LLLRNprLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 317 LLSDRFGRRPFIILGSVALFALaipafilinsdVLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHI-----RYSALAA 391
Cdd:cd17324 256 RLADRGGRRALLIALLLLAAAL-----------LLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVlrlapEARGLAS 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 658547747 392 AFNISVL-IAGLTPTLAASLVESTQNLMMPAYYLMVIAVIGLITGL 436
Cdd:cd17324 325 SLYLAAYnLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
72-438 |
3.14e-16 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 80.30 E-value: 3.14e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 72 FSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLICKMAQGFSVGGEYTGASIF 151
Cdd:COG2807 59 TTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVA--------LLLAGTALIGAGIAVGNVLLPGL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 152 VAEYSPDRkRGFMGSWLDFGSIAGFVMGAGVVVLISTVvgednfldWGWRIPF-FLALPLGIIGLYLRHALEETPAFQQH 230
Cdd:COG2807 131 IKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAA--------LGWRGALaVWALLALLALLLWLPLLRRRPAAAAA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 231 VekleqgdreglqdGPKVSFKEIatkhWRS----LLTCIGLVIStnVTYYMLLTYMPSYLsHNLHYSEDHGVLIIIAIMV 306
Cdd:COG2807 202 A-------------PAAASLRSL----WRSplawLLTLFFGLQS--LLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 307 GMLFVQPIMGLLSDRFGRRPFIILGSVALFALAIPAFILINSdvlGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRY 386
Cdd:COG2807 262 AGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPG---SLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEA 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 658547747 387 SAL-AAAFNISVLIAGLTPTLAASLVESTQNLMMPAYYLMVIAVIGLITGLTM 438
Cdd:COG2807 339 AALsGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
77-430 |
1.08e-15 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 79.18 E-value: 1.08e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 77 LIRPLGGLFFGMLGDKYGRQK-ILAITIVIMSISTFCIGLIPSYATIG--IWAPILLLICKMAqgfsvggeYTGASI--- 150
Cdd:COG2211 61 ITDPLIGALSDRTRTRWGRRRpWILIGAIPLALSFVLLFTAPDLSPTGklIYALVTYLLLGLA--------YTLVNIpys 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 151 -FVAEYSPDRK-RGFMGSWLDFGSIAGFVMGAGVVVLISTVVGEDNFldWGWRIPFFLALPLGIIGLYL-RHALEETPAF 227
Cdd:COG2211 133 aLGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAA--LGYRLTALIFAVLGLLAFLLtFFGTKERPVP 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 228 QQhvekleqgdreglqdgPKVSFKEI--ATKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIM 305
Cdd:COG2211 211 EE----------------EKVSLKESlkALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYF 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 306 VGMLFVQPIMGLLSDRFGRRPFIILGSvALFALAIPAFILINSDVLGLIFAgllmLAVILNCFIGVMASTLPAMFP---- 381
Cdd:COG2211 275 LAALLGAPLWPRLAKRFGKKKAFIIGL-LLAALGLLLLFFLGPGNLWLLLV----LAALAGIGLGAILVLPWAMLAdvvd 349
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 658547747 382 -----THIRYSALAAAFN-----ISVLIAGLTPTLAASLVESTQNLMMPAYYLMVIAVI 430
Cdd:COG2211 350 ydewkTGRRREGLYFGIFtfaikLGQALAGALAGLLLALFGYVAGAAQSPSALTGIRLL 408
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
85-379 |
4.98e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 76.44 E-value: 4.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 85 FFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFM 164
Cdd:cd17478 50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW--------LLLLLVALAGIGSAAFHPEGARLASQAAGGRRGLAM 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 165 GSWLDFGSIaGFVMGAGVVVLIstvvgednFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVEKleqgdreglqd 244
Cdd:cd17478 122 SIFSVGGNL-GFALGPLIAAAL--------VALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAA----------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 245 gPKVSFKEIATKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLhYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGR 324
Cdd:cd17478 182 -AKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG-YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGR 259
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 658547747 325 RPFIILGsvalFALAIPAFILinsdvlgLIFAGLLMLAVILNCFIGVMASTLPAM 379
Cdd:cd17478 260 RRVIIAS----LLLAAPFLLL-------FLLTPGIWSYILLVLAGFLLFASFPVT 303
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
30-447 |
5.37e-15 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 76.99 E-value: 5.37e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 30 ASLGNAMEWFDFGVY-GFVAYALGKVFFPGADPSLQMIAALGTFSVPFLIRPL-GGLFFGMLGDKYGRQKILAITIVIms 107
Cdd:TIGR00879 33 AAIGGLMFGYDTGVIgGALALPAFEFKFTSANSDSYSSSLWGLVVSIFLVGGFiGALFAGWLSDRFGRKKSLLIIALL-- 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 108 istFCIGLIPSYATIGIWAPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGS----WLDFGSIAGFVMGAGVV 183
Cdd:TIGR00879 111 ---FVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSlyqlAITFGILVAYGFGSGKV 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 184 VLISTVvgednfldwGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVEKLEQG-------------DREGLQDGPKVSF 250
Cdd:TIGR00879 188 SLNNTL---------GWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEArkslarlrgtsgeDKELLDELELIDI 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 251 KEIATKH-----WRSLLTC-----------IGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIM-VGMLFVQP 313
Cdd:TIGR00879 259 KRSIEKRsvqpsWGSLFSStrrirrrlflgVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGaVNFAFTFV 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 314 IMGLlSDRFGRRPFIILG----SVALFALAIPAFILINSDVL---GLIFAGLLMLAVILNCFIGVMASTLPA-MFPTHIR 385
Cdd:TIGR00879 339 AIFL-VDRFGRRPLLLIGaagmAICLFVLGILGASFVTGSSKssgNVAIVFILLFIAFFAMGWGPVPWVIVSeIFPLSLR 417
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 386 YSALAAAFN----ISVLIAGLTPTLAASlvestqnlMMPAYYLMVIAVIGLITGLTMK----ETANRPLK 447
Cdd:TIGR00879 418 PKGISIAVAanwlANFIVGFLFPTMLES--------IGVGGVFIFFGGLNVLGLIFVYfflpETKGRTLE 479
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
84-421 |
5.76e-15 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 76.44 E-value: 5.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 84 LFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSyatigiwaPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKR-- 161
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIGAAAIMPASLALIAATFPGERRgr 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 162 --GFMGSWLDFGSIAGFVMGAGVVVListvvgednfldWGWRIPFFLALPLGIIGLYLrhaleeTPAFqqhvekleqgdr 239
Cdd:cd17321 121 alGLWGAVVGIGAALGPLLGGLLLEL------------FGWRWIFLINVPIGLVALLL------ARTF------------ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 240 eglqdgpkvsfkeiatkhwrsLLTCIGLVIsTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLS 319
Cdd:cd17321 171 ---------------------SGAVLAAFL-LGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 320 DRFGRRPFIILGSVALFALAIPAFILINSDVLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSA---------LA 390
Cdd:cd17321 229 DRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAAsgilntarqLG 308
|
330 340 350
....*....|....*....|....*....|.
gi 658547747 391 AAFNISVLIAGLTPTLAASLVESTQNLMMPA 421
Cdd:cd17321 309 GALGVALLGALLTAGLSANLGDSGVAALLSA 339
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
81-392 |
1.89e-14 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 74.91 E-value: 1.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATIGIWAPILllickmaqGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIG--------GLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 161 RGFMGSWLDFGSIAGFVMGAGVVVLISTVVGEDNFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFqqhvekleqgdre 240
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRW------------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 241 glqdgpkvsfkeIATKHWRSLLTCIGL-----VISTNVTYYmlltYMPSYLShNLHYSEDHGVLIIIAIMVGMLFVQPIM 315
Cdd:cd17359 190 ------------LVSKGKPILIIGIGLaifqqFVGINVIFY----YGPEIFQ-NAGFSENAALLQTIGIGVVNVIFTIIA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 316 GLLSDRFGRRPFIILGS----VALFALAIPAFILINSDVLGlifaglLMLAVILNCFIGVMAST--------LPAMFPTH 383
Cdd:cd17359 253 ILLVDKVGRKPLLLIGSigmaISLLLIGTAFYFAPGSQASG------IVALVLILLFVAFFAMSwgpvtwvlLSEIFPNR 326
|
....*....
gi 658547747 384 IRYSALAAA 392
Cdd:cd17359 327 IRGLAMGIA 335
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
25-233 |
2.79e-14 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 75.15 E-value: 2.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 25 KAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSLQMIAALGTFSVpFLIRPLGGLFFGMLGDKYGRQKILAITIV 104
Cdd:TIGR00887 16 RAIVIAGVGFFTDSYDLFCISLVTKMLGYVYYHGKGPLPSSVSAAVNGSA-SIGTLAGQLFFGWLADKLGRKRVYGMELI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 105 IMSISTFCIGLIPSYATIGIWApiLLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRG-FMGSWLDFgsiAGF-VMGAGV 182
Cdd:TIGR00887 95 IMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGaMMAAVFAM---QGFgILAGAI 169
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658547747 183 VVLISTVVGEDNF----------------LDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVEK 233
Cdd:TIGR00887 170 VALIVLAGFKHSLeaaadeasctgscvpaVDYMWRILIGFGAVPALLALYFRLTIPETPRYTADVAK 236
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
81-446 |
4.60e-14 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 74.28 E-value: 4.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigiwapILLLICKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY--------TVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 161 RGFMGSWLDFGSIAGFVMGAGVVVLIStvvgednflDWGWrIPFFLALPLGIIGLY------------LRHALEETPAFQ 228
Cdd:TIGR00898 214 RAIVGTLIQVFFSLGLVLLPLVAYFIP---------DWRW-LQLAVSLPTFLFFLLswfvpesprwliSQGRIEEALKIL 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 229 QHVEKLE-----------QGDREGLQDGPKVSFKEIATKHW--RSLLTCIGLVISTNVTYYMLLTYMPsylshNLHYSed 295
Cdd:TIGR00898 284 QRIAKINgkklpaevlslSLEKDLSSSKKQYSFLDLFRTPNlrKTTLCLMMLWFTTAFSYYGLVLDLG-----NLGGN-- 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 296 hgVLIIIAIMVGMLFVQPIMGLLS-DRFGRRPfIILGSVALFALAIPAFILINSD----VLGLIFAGLLMLAVILNCfIG 370
Cdd:TIGR00898 357 --IYLDLFISGLVELPAKLITLLLiDRLGRRY-TMAASLLLAGVALLLLLFVPVDlyflRTALAVLGKFGITSAFQM-VY 432
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 658547747 371 VMASTLpamFPTHIRYSALAAAFNISVLIAGLTPTLAASlveSTQNLMMPAYYLMVIAVIGLITGLTMKETANRPL 446
Cdd:TIGR00898 433 LYTAEL---YPTVVRNLGVGVCSTMARVGSIISPFLVYL---GEKWLFLPLVLFGGLALLAGILTLFLPETKGVPL 502
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
39-358 |
1.10e-13 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 72.70 E-value: 1.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 39 FDFGVYGFVAYALGKVFF--PGADPS-----LQMIAALGTFsvpflirpLGGLFFGMLGDKYGRQKILAITIVIMSISTF 111
Cdd:cd17364 13 YDLFSISLVTKILGRLYYggKGSLPSgvsglVNAAALVGTI--------IGQLFFGFLGDRFGRKRVYGVELIIMIIGTI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 112 CIGLIPSYATIGIWApiLLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFM----GSWLDFGSIAGfvmgaGVVVLIS 187
Cdd:cd17364 85 LSALSPGSTPLGVMG--WLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALiaavFAMQGFGILAG-----AIVTLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 188 TVVGEDNF-------LDWGWRIPFFLALPLGIIGLYLRhaleetpafqqhvekleqgdreglqdgpkvsfkeiatkhwRS 260
Cdd:cd17364 158 SAIFEHPLpagtyhhADLVWRIVLGLGAIPALSVLYFR----------------------------------------KH 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 261 LLTCIGLVISTNVTYYMLLTYMPSYLSH-------NLHYSE-DHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILG- 331
Cdd:cd17364 198 LLGTAGTWFLLDIAFYGQNLFQSTIISAigfsktmNAYQELfNIAVGQLIIALAGTVPGYWFTVFLIDRIGRKKIQMMGf 277
|
330 340 350
....*....|....*....|....*....|
gi 658547747 332 ---SVALFALAIPAFILINSDVLGLIFAGL 358
Cdd:cd17364 278 fgmTIFLLILAGPYDHWKISTIGFFVLYGL 307
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
50-359 |
1.80e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 71.84 E-value: 1.80e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 50 ALGKVFFPGADPSLQMIaalgtFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigiwapIL 129
Cdd:cd17473 24 AIAQHFVPNSELLVPLL-----LTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSL--------YA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 130 LLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMgswldFGSIAGFV-MGAGVVVLISTVVGEdnfldWGWRIPFFL-A 207
Cdd:cd17473 91 LLASRALLGIGVAGIMTLATALIGDYFEGEERAKM-----LGLQSAAMsLGGVVFLLLGGALAE-----IGWRAPFLVyL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 208 LPLGIIGLYLRhALEETPAFQQHVekleqgdreglqdgPKVSFKEIATKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLS 287
Cdd:cd17473 161 LALPVLILVLL-FLPEPARKSKSA--------------ASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQ 225
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 658547747 288 HNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRpFIILGSVALFALAIpAFILINSDVLGLIFAGLL 359
Cdd:cd17473 226 ERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKR-RLLAIGFALMALGF-LLLALASGLWVVLLGAIL 295
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
62-434 |
1.96e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 71.47 E-value: 1.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 62 SLQMIAALgtfsvpfLIRPLGGLffgmLGDKYGRQKILAITIVIMSISTFCIGLIPSyatigiwaPILLLICKMAQGFSV 141
Cdd:cd17489 38 GLFTLAAL-------LARPFAGR----LLDRFGRKRLLLIGLLIFALATLLYLLATS--------VALLLVLRLIHGIGW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 142 GGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISTVvgednfldWGWRIPFFLALPLGIIGLYLrhal 221
Cdd:cd17489 99 GAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQH--------LGFAVLFIVAAVLALLALLL---- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 222 eetpAFQQHVEKLEQGDREGLQDGPKVSFKEIatkhwRSLLTCIGLVISTnVTYYMLLTYMPSYLSHNLHyseDHGVLII 301
Cdd:cd17489 167 ----VFLVKDPPPVAAEEAEAGTRAFRRLVEK-----KVLPPALILFLAS-IAYGAISTFLPLYAAERGI---SNAGLFF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 302 IAIMVGMLFVQPIMGLLSDRFGRRPFIILGSVaLFALAIPAFILINSDVLGLIFAGLLMLAvilncfIGVMASTLPAMF- 380
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLL-LLALGLLLLSFAGSPWMLLLAAVLYGLG------FGLLFPALQALAv 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 658547747 381 ---PTHIRYSALaAAFNISVLIA-GLTPTLAASLVESTQNLMMPAYYLMVIAVIGLIT 434
Cdd:cd17489 307 dlvPPHRRGAAN-GTFFIFFDLGiGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
84-433 |
4.79e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 70.68 E-value: 4.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 84 LFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLICKMAQGFSVGGEYTGASIFVAEYSPDRKR-- 161
Cdd:cd17474 52 PVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFAL--------LLAGRALQGIGAAGLGPLALTLIGDLFEGGERak 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 162 --GFMGSWLDFGSIAGFVMGAGVVvlistvvgednflDWGWRIPFFLALPLGIIGLYLRHALEETPAfqqhvekleqgdR 239
Cdd:cd17474 124 amGLYEAALGLGIAVGPLLGGLLA-------------AISWRYPFFLLAALIPVAFLAILFLLPEPK------------E 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 240 EGLQDGPKVSFKEIATKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLS 319
Cdd:cd17474 179 KAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 320 DRFGRRPFIILGSVALFALAIPAFILINSdvLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALaAAFNISVLI 399
Cdd:cd17474 259 KKRFGARRILVIGLLLYALSLLLLGFVPS--LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTAS-SLYNFVRFL 335
|
330 340 350
....*....|....*....|....*....|....
gi 658547747 400 AGLTPTLAASLVESTQNLMMPAYYLMVIAVIGLI 433
Cdd:cd17474 336 GQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
63-382 |
1.17e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 69.50 E-value: 1.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 63 LQMIAALGTFsvpflirpLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigiwapILLLICKMAQGFSVG 142
Cdd:COG0738 48 LLFAFFLGYL--------LASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY--------PLLLLALFLLGLGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 143 GEYTGASIFVAEYSPDRKRGFMgSWLD-FGSIAGFVMGAGVVVLIStvvgedNFLDWGWRIPFFL--ALPLGIIGLYLRH 219
Cdd:COG0738 112 LLDVAANPYVAALGPETAASRL-NLLHaFFSLGALLGPLLGGLLIL------LGLSLSWHLPYLIlaVLLLLLALLFLRS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 220 ALEETPAfqqhvekleqgdREGLQDGPKVSFKEIAtKHWRSLLTCIGLVISTnVTYYMLLTYMPSYLSHNLHYSEDHGVL 299
Cdd:COG0738 185 KLPEIEE------------EEEEAAGSAASLKSLL-KNPRLLLGGLAIFLYV-GAEGAIGDWLPLYLKDVLGLSEATAAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 300 IIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSVALFALaipafilinsdVLGLIFAGLLMLAVILNCFIGVMAStlpAM 379
Cdd:COG0738 251 GLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG-----------LLLALLAPGPWLALIGLALVGLGLS---LM 316
|
...
gi 658547747 380 FPT 382
Cdd:COG0738 317 FPT 319
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
34-438 |
4.26e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 67.23 E-value: 4.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 34 NAMEWFDFGVYGFVAYALGKVFfpGADPslqmiAALGT-FSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFC 112
Cdd:cd17365 8 IVLDGFDLAVMGFVAPALAQDW--GLSP-----AQLGPvGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 113 IGLIPSYATIGIWapilllicKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLdfgsIAGFVMGAGVVVLISTVVGE 192
Cdd:cd17365 81 TAFAQSVLQLALL--------RFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLM----FCGYPLGAALGGFLAAALIP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 193 dnflDWGWRIPFFL-ALPLGIIGLYLRHALeetpafqqhvekleqgdreglqdgpkvsfkeiatkhWRSLLTCIGLVIst 271
Cdd:cd17365 149 ----AFGWRSVFLLgGVPPLILLPLLRGTL------------------------------------LLWVTFFMGLLL-- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 272 nvtYYMLLTYMPSYLSHNlHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSV--ALFALAIPAFilinSD 349
Cdd:cd17365 187 ---VYLLNSWLPKLMVEA-GYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFAlgAVSLALLGVS----PA 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 350 VLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNISVLIAGLTPTLAASLVESTQNLMMPAYYLMVIAV 429
Cdd:cd17365 259 SLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAA 338
|
....*....
gi 658547747 430 IGLITGLTM 438
Cdd:cd17365 339 LGALAVLLL 347
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
81-446 |
6.92e-11 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 63.91 E-value: 6.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLICKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 161 RGFMGSWLDFGSIAGFVMGAGVVVLISTVVgednfldWGWRIPFFLALPLGII---GLYLrhaLEETPAFQQHVEkleqg 237
Cdd:cd17362 126 RGLLVSLKELFIVLGILLGYVSGYAFADVV-------GGWRYMYGLAAPPALLlgiGMWF---LPPSPRWQGNYR----- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 238 dreglqdgpkvsfkeiatkhwRSLLTCIGLVISTNVT-YYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMG 316
Cdd:cd17362 191 ---------------------KPLIIGLGLVLFQQITgQPSVLYYAATIFKSAGFSAASDATLVSVGLGVFKLLMTIVAV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 317 LLSDRFGRRPFIILGS----VALFALAIpAFILINSDVLGLIFAGLLMLAVILNCF-IG------VMASTLpamFPTHIR 385
Cdd:cd17362 250 LLVDKLGRRPLLLGGVsgmvVSLFLLAA-YNLFVQMGPAGLAWLSLVALLLYVGAYqISfgpiswLMVSEI---FPLRVR 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 658547747 386 YSALAAAfNISVLIAGLTPTLAASLVESTqnLMMPAYYLM--VIAVIGLI-TGLTMKETANRPL 446
Cdd:cd17362 326 GRAIALA-VLVNFGSNALVSLAFLPLQEL--IGLPGTFLGfgVIGVLALLfIYFTVPETKGLSL 386
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
81-436 |
7.15e-11 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 63.37 E-value: 7.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLICKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17317 40 IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 161 RGFMGSWLDFGSIAGFVMGAGVVVLIStvvgednflDWGWrIPFFLALPlGIIGLYLrhaleetpafqqhvekleqgdre 240
Cdd:cd17317 112 RSFVGILFGLFWALGYMLLALLAYLIR---------DWRW-LQLAISLP-GLLFLLL----------------------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 241 gLQDGPKVSFkeiatkhwrsLLTCIGLVIStnVTYYMLLTYMPSyLSHNLH----YSedhGVLIIIAIMVGMLFVqpimg 316
Cdd:cd17317 158 -LWWLPRRTI----------IVGLIWFVTS--LVYYGLSLNSSN-LGGNLYlnffLS---GLVEIPAYFLALLLL----- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 317 llsDRFGRRPF----IILGSVALFALaipAFILINSDVLGLIFAGLLMLAV-ILNCFIGVMASTLpamFPTHIRYSALAA 391
Cdd:cd17317 216 ---DRLGRRWTlsgsLLLAGLACLVT---ALLPDDENTLALTLALVGKFAIsAAFSVIYLYTAEL---YPTVVRNTGVGL 286
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 658547747 392 AFNISVLIAGLTPTLaASLVESTQNLMMpayylMVIAVIGLITGL 436
Cdd:cd17317 287 CSTVARVGAILAPFI-VLLGKIGPLLPL-----IIFGVLALLGGL 325
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
81-438 |
1.17e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 62.96 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSyatigiwaPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17477 46 LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS--------PWVWFLLRFVMGIGLAGLFVVSESWLNALATNEN 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 161 RGFMGSWLDFGSIAGFVMGAGVVVLISTVvgednfldwGWRIPF----FLALPLGIIGLYLRHALEETPAfqqhvekleq 236
Cdd:cd17477 118 RGRVLGLYSTVLGLGFALGPLLLALVGTA---------GALPFLiaavLLLLALVPLLLTRRAAPEIEEA---------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 237 gdreglqdgPKVSFKEIATKHWRSLLTCI--GLVISTnvtyymLLTYMPSYLSHnLHYSEDHGVLIIIAIMVGMLFVQPI 314
Cdd:cd17477 179 ---------ESISLRRLLRIAPLALLGAFvaGFLEGA------FYSLLPLYGLR-LGLSVAQAALLLAAFVLGGLLLQWP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 315 MGLLSDRFGRRPFIILGSVALFALAIPAFILINSDVLglifagLLMLAVILNCFIGVM---ASTLPAMFPTHIRYSALAA 391
Cdd:cd17477 243 LGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLA------LLVLLFLWGGAAGPLytlALALAGDRLPGDELVAANA 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 658547747 392 AFNISVLIAGLTPTLAASLVestQNLMMPAYYLMVIAVIGLITGLTM 438
Cdd:cd17477 317 ALLLLYGLGSVIGPLLAGAL---MDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
29-393 |
1.93e-10 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 62.21 E-value: 1.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 29 AASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSLQ--MIAALGTFSVpflirpLGGLFFGMLGDKYGRQKILAITIVIM 106
Cdd:cd17315 1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQglVVSSLLLGAA------IGSLFGGPLADRFGRRKSLLIAAVLY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 107 SISTFCIGLIPSYATigiwapilLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGS----WLDFGSIAGFVMGAGV 182
Cdd:cd17315 75 VIGALLSALAPNVWV--------LIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTlnqlMITFGILLAYLLGLAL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 183 VVLIStvvgednfldWGWRIPFFLALPLGIIGLYLRHALEETPAfqqhvekleqgdreglqdgpkvsfkeiatkhwrsLL 262
Cdd:cd17315 147 SLSPP----------GWWRLMFALAAVPALLQLLLMFFLPESRA----------------------------------LL 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 263 TCIGLVIST-----NVTYYmlltYMPSYLShNLHySEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILG----SV 333
Cdd:cd17315 183 VGVGLQLLQqltgiNAVMY----YAPTIFK-SAG-GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGfagmAA 256
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 658547747 334 ALFALAIPAFILINSDVLGLI-FAGLLMLAVILNCFIGVMASTL-PAMFPTHIRYSALAAAF 393
Cdd:cd17315 257 SLLLLAIAFLLPALAKAAGWLaLLGILLYIAAFAMGAGPVPWLLlSEIFPLRIRGKGMAIAT 318
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
258-412 |
3.85e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 61.53 E-value: 3.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 258 WRSLLTCIGLVISTNVTYYMLLTYMPsYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPfIILGSVALFA 337
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRR-VLLLGLLLFA 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 658547747 338 LAIPAFILINSdvLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIR---YSALAAAFNISVLIAgltPTLAASLVE 412
Cdd:COG2814 87 LGSLLCALAPS--LWLLLAARFLQGLGAGALFPAALALIADLVPPERRgraLGLLGAGLGLGPALG---PLLGGLLAD 159
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
71-436 |
4.58e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 61.44 E-value: 4.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 71 TFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLICKMAQGFSVGGEYTGASI 150
Cdd:cd17320 39 TLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--------LLIARFLQGLGAAAGSVVARA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 151 FVAEYSPDRKRgfmgswldfGSIAGFVMGA-GVVVLISTVVGEDNFLDWGWRIPF-FLALPLGIIGLYLRHALEETpafq 228
Cdd:cd17320 111 IVRDLYSGAEL---------AKIFSLLMMIlAIAPALAPLLGGLLLLFFGWRAIFvFLALLGLLLLLLVLLFLPET---- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 229 QHVEKLEQGDREGLQDGPKVsfkeIATKHWRSLLTCIGLVISTNVTYymlLTYMPSYLSHNLHYSEDHGVLIIIAIMVGM 308
Cdd:cd17320 178 LPEEKRKPLLSSLLRAYKRV----LKNRRFLGYALALGLSFAGLFAY---LAAAPFIYIEQLGLSPAQFGLLFALNAIAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 309 LFVQPIMGLLSDRFGRRPFIILGSVALF--ALAIPAFILINSDVLgLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRY 386
Cdd:cd17320 251 ILGSLLNGRLVRRFGPRRLLRLGLLLLLaaALVLLLAALLGGLSL-WPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAG 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 658547747 387 SALAAAFNISVLIAGLTPTLAASLVESTQNLMMPAYYLMVIAVIGLITGL 436
Cdd:cd17320 330 TASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
73-436 |
4.64e-10 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 61.44 E-value: 4.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 73 SVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigiwapILLLICKMAQGFSVGGEYTGASIFV 152
Cdd:cd17358 48 SLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDV--------WMLYLGRFLAGFGGGAASVVVPVYI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 153 AEYSPDRKRGFMGS----WLDFGSIAGFVMGagvvvlistvvgedNFLDWGWrIPFFLALPLGI--IGLY---------- 216
Cdd:cd17358 120 AEIAPKNVRGALGSlnqlLVNIGILLGYVLG--------------SFLPWRT-LALIGAIPPVVflILLFfipesprwla 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 217 -------LRHAL-----------EETPAFQQHVEKLEqgdreglQDGPKVSFKEIATKHW-RSLLTCIGLVI------ST 271
Cdd:cd17358 185 kkgreeeAEKSLqflrgkdadisKEAAEIQEELAELE-------KEAKESSFSDLFQRKYlKPLVIGLGLMLfqqlsgIN 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 272 NVTYYMlltympSYLSHNLH--YSEDHGVLIIIAIMVGMLFvqpIMGLLSDRFGRRPFIILGSV--ALFALAIPAFILIN 347
Cdd:cd17358 258 AVIFYA------SSIFDEAGsgLDPNTATIIIGVVQVVGTL---VATLLVDRLGRRPLLLVSAIgmGIGLLALGLYFYLQ 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 348 SDVLGL----IFAGLLMLAVILNCFIGVMAstLPA-----MFPTHIRYSALAaafnisvlIAGLTPTLAASLVESTQNLM 418
Cdd:cd17358 329 EHGALLssvsWLPLVGLVIYIISFSIGLGP--LPWvimseIFPAKIKGLAGS--------LVTLVNWLFAFIVTKTFPFL 398
|
410 420
....*....|....*....|..
gi 658547747 419 M----PAYYLMVIAVIGLITGL 436
Cdd:cd17358 399 TlawgASGTFWIFAGICGLALV 420
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
58-390 |
1.43e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 59.94 E-value: 1.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 58 GADPSLQMIAALgTFSVPFLIrplGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLICKMAQ 137
Cdd:cd17328 30 LIDDSLAGLLQT-VFIISYMV---LSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFW--------QLLLFRALV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 138 GFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDF----GSIAGFVMGAgvvvLISTVVGednfldwGWRIPFFLALPLGII 213
Cdd:cd17328 98 GIGEASYSPIAPTIIADLFPKEKRTRALGVFYFaiplGSGLGYVVGG----LVAQATG-------GWRWAFRVTGVLGVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 214 -GLYLRHALEETPAFQQHVEKLEQGDREGLQDGPKVSFkeiatKHWRSLLTCIGLVISTNVTyYMLLTYMPSYL---SHN 289
Cdd:cd17328 167 lAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALA-----KNPSFILSTLGFTAVSFVT-GALAFWAPTFFlraFGV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 290 LHYSEDHGVLI--IIAIMVGMLFVqPIMGLLSDRFGRRP---FIILGSVALFALAIPAFILINSDVLGLIFA-GLLMLAV 363
Cdd:cd17328 241 GDLSSADVGLIfgAITCIAGVLGV-LLGGILADRLRRKTpraDPLVCAVGLLAAAPFLFLALVLALSNLLLAwVLLFLGE 319
|
330 340
....*....|....*....|....*....
gi 658547747 364 ILNCFIG--VMASTLPAMFPTHiRYSALA 390
Cdd:cd17328 320 FLLSLNWapVFAILLYVVIPTR-RSTASA 347
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
41-373 |
1.50e-09 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 59.95 E-value: 1.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 41 FGVY-GFVAYALGKVFFPGADPSLQMI-----AALGTFSVPFLIR-PLGGLFFGMLGDKYGRQKILAITIVIMSISTFCI 113
Cdd:cd17345 6 LGIFiGYAGYYLVRNNFSLAQPYLIEQyglskTEIGLIGSALSIAyGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 114 GLIPSY-ATIGIWApILLLICKMAQGFSVGGEYtgasIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISTVVGE 192
Cdd:cd17345 86 GFVPSAtSSVGLMF-ILLFLNGWFQGMGWPPSG----RTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 193 DNFLdWGWRIPFFLALPLGIIGLYLRHALEET---PAFQQHVEKlEQGDREGLQDGPKVSFKEIATKH-------Wrsll 262
Cdd:cd17345 161 GWWR-GAFIFPAIIAIIVAVIVLFLGKDTPESeglPPIEEYKGD-YPEEADGEEEEQELSAWEIFVKYvlknkllW---- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 263 tcigLVISTNVTYYML----LTYMPSYLSHNLHYSEDHGVLII----IAIMVGMLfvqpIMGLLSDRF--GRRPFIILGS 332
Cdd:cd17345 235 ----YIAIANVFVYLVrygiLDWAPTYLSEVKGFSKAQAMWAFslfeWAAIPGTL----LAGWLSDKLfkGRRAPTGIIF 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 658547747 333 VALFALAIPAFILINS---DVLGLIFAGLLMLAVILncFIGVMA 373
Cdd:cd17345 307 MILVIVALIVYWLAPNvlvDLIALIALGFLIYGPVM--LIGLQA 348
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
67-432 |
1.74e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.55 E-value: 1.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 67 AALGTFSVPFLirpLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATIGIWAPILLLICKMAQG-FSVGGEY 145
Cdd:cd06173 38 LVLAAFFLPFL---LFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASaFFGPARQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 146 TGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISTVVGednFLdwgwrIPFFLALPLGIIGLYLRHALEETP 225
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA---FA-----INALSFLLSALLLLFIRRPPPAAP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 226 AfqQHVEKLEQGDREGLQDgpkvsfkeiaTKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIM 305
Cdd:cd06173 187 G--ESSSLLLRDLREGLRY----------LRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 306 VGMLFVQPIMGLLSDRFGRRPFIILGsVALFALAIPAFILINSDVLGLIFAGLLMLAVIlnCFIGVMASTLPAMFPTHIR 385
Cdd:cd06173 255 VGALLGALLLGRLSKRRRRGRLLLIG-ALLLGLALLVLGLSPSLWLLLAALFLLGLAGG--LFNVPLNTLLQLRVPDELR 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 658547747 386 YSALAAAFNISVLIAGLTPTLAASLVESTqnLMMPAYYLMVIAVIGL 432
Cdd:cd06173 332 GRVFSVYNALNSGAMPLGALLAGLLADAL--GLSAVFLLAGALLLLA 376
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
82-431 |
2.36e-09 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 59.21 E-value: 2.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 82 GGLFFGMLGDKYGRQKILaitivIMSISTFciGLIpSYATIGIWAPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKR 161
Cdd:PRK11551 66 GALLGGRLADRIGRKRIL-----IVSVALF--GLF-SLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 162 GFMGSWLdfgsIAGFVMGAGVVVLISTVVGEDNfldwGWRIPFFL--ALPLGIIGLYLRHaLEETPAFQQhvekleqgdr 239
Cdd:PRK11551 138 GTAVSLM----YCGVPFGGALASVIGVLAAGDA----AWRHIFYVggVGPLLLVPLLMRW-LPESRAFAQ---------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 240 EGLQDGPKVSFKEIATKHWRSLLTcIGLVIS---TNVTYYMLLTYMPSYLSHNlHYSEDHGVLIIIAIMVGMLFVQPIMG 316
Cdd:PRK11551 199 AAGAGKQRAPVLRALFGEGRATAT-LLLWISyffTLIVLYFLLNWLPSLLVGQ-GLSRSQAGLVQIAFNIGGALGSLLIG 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 317 LLSDRFGRRPFIIL---GSVA-LFALAI-PAFILInsdVLGLIFAGLLMLAVILncfigVMASTLPAMFPTHIRYSALAA 391
Cdd:PRK11551 277 ALMDRLRPRRVVLLiyaGILAsLAALAAaPSFAGM---LLAGFAAGLFVVGGQS-----VLYALAPLFYPTQVRGTGVGA 348
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 658547747 392 AFNISVLIAGLTPTLAASLV---ESTQNLMMPAYYLMVIAVIG 431
Cdd:PRK11551 349 AVAVGRLGSMAGPLLAGQLLalgRSTVGVIGASIPVILVAALA 391
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
87-376 |
2.54e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 59.13 E-value: 2.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 87 GMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGS 166
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 167 WLDFGSIAGFVMG---AGVVVlistvvgeDNFldwGWRIPFFLALPLGIIGLYLrhaleetpafqqhvekleqgdreglq 243
Cdd:cd17503 124 LVGLVILLAPAIGptlGGWLT--------DNL---SWRWIFYINLPIGILALLL-------------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 244 dGPKVSFKEIATKHWRSLLTCIGLVistNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFG 323
Cdd:cd17503 167 -APLLDLRLFKDRNFTLGLLLSFLL---GLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFG 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 658547747 324 RRPFIILGSVAL-FALAIPAFILINSDVLGLIFAGLLMLAVILNCFIGVMASTL 376
Cdd:cd17503 243 PRLLLLAGLLLLaLGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLAL 296
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
72-433 |
6.02e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 58.05 E-value: 6.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 72 FSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtiGIWAPILLLIckmaqGFSVGGEYTGASIF 151
Cdd:cd17355 44 FTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLW--QLYLLWGLLG-----GGGAGTLAAVAFAT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 152 VAEYSPDRKRGF-MGSWLDFGSIAGFVMGAGVVVLISTvvgednfldWGWRIPF----FLALPLGIIGLYLRHALEETPA 226
Cdd:cd17355 117 VAAWWFERRRGLaLGILTAGGGLGSLVFLPLGAALIEA---------FGWRTALlvlaLLALLVLVPVLLLLRRRPADLA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 227 FQQHVEKLEQGDREGLQDgpkvsfkeiATKHWRSLLTCIGLVIsTNVTYYMLLTYMPSYLSHnLHYSEDHGVLIIIAIMV 306
Cdd:cd17355 188 LRAYDDASPASPGSTLKE---------ALRSASFWLLALAFFL-CGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 307 GMLFVQPIMGLLSDRFGRRPfIILGSVALFALAIPAFILINSDVLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTH--I 384
Cdd:cd17355 257 FNIVGRLLSGWLGDRYSPRR-LLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSygT 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 658547747 385 RYSALAAAFNISvliAGLTPTLAASLVESTQNLMMPAYYLMVIAVIGLI 433
Cdd:cd17355 336 LFGLVFAPHQLG---SALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
274-456 |
1.05e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 57.04 E-value: 1.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 274 TYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGsvaLFALAIPAFILINSDVLGL 353
Cdd:pfam07690 11 GRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIG---LLLFALGLLLLLFASSLWL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 354 IFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNISVLIAGLTPTLAASLVESTQnlmmPAYYLMVIAVIGLI 433
Cdd:pfam07690 88 LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG----WRAAFLILAILSLL 163
|
170 180
....*....|....*....|...
gi 658547747 434 TGLTMKETANRPLKGATPAASDI 456
Cdd:pfam07690 164 AAVLLLLPRPPPESKRPKPAEEA 186
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
255-464 |
4.47e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 55.27 E-value: 4.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 255 TKHWRsLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDH-GVLIIIAIMVGMLFvQPIMGLLSDRFGRRpfiILGSV 333
Cdd:COG2223 1 SGRWR-VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQlGLLFAIPVLVGALL-RIPLGFLVDRFGPR---RVLLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 334 ALFALAIPAFIL-INSDVLGLIFAGLLMLAVILNCFIGVMAsTLPAMFPTHIRYSAL---AAAFNISVLIAGLtptLAAS 409
Cdd:COG2223 76 GLLLLGIGLLLLaLAVSYWLLLLLGLLLGIGGGGSFAVGIA-LVSKWFPPDRRGLALglaAGGGNLGAAVAAF---LAPL 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 658547747 410 LVESTQNLMMPAYYLMVIAVIGLITGLTMKETanrPLKGATPAASDIQEAKEILR 464
Cdd:COG2223 152 LIAAFGWRNAFLILGILLLVVAVLAWLFLRDP---PAGAAAAAKASLRDQLEALR 203
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
84-382 |
6.12e-08 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 54.49 E-value: 6.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 84 LFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLICKMAQGFSVGGEYTGASIFVAEYSPDRKR-- 161
Cdd:cd17502 48 PIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTM--------LIVGRAIQGIGGGGLMSLAFIIIADLVPPRERgk 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 162 --GFMGSWLDFGSIAGFVMGAGVVVLIStvvgednfldwgWRIPFFLALPLGIIGLYLrhaleetpafqqhvekleqgdr 239
Cdd:cd17502 120 yqGYIGAVFGIASVAGPLIGGAFTDHLS------------WRWCFYINLPIGGLALAL---------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 240 eglqdgpkvsfkeiatkhWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLS 319
Cdd:cd17502 166 ------------------LRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALI 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 658547747 320 DRFGRRPFIILGSVALFALAIPAFILINSDVLGLIFAGLLMLA------VILNCFIGVMASTLPAMFPT 382
Cdd:cd17502 228 SKTGRYKPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLglglgiGFQQPLVAVQNAVPPADVGV 296
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
73-432 |
1.26e-07 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 53.69 E-value: 1.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 73 SVPFLIRPLGGLFFGMLGDKYGRQKILAITIVImsisTFCIGLIPSYATIGIWapilLLICKMAQGFSVGGEYTGASIFv 152
Cdd:cd17372 41 SVVFAGMMIGSYLWGIVSDKYGRRKGLIISALW----TFYAGFLSAFAPNYMW----LIILRCLVGLGLGGGPQLASWY- 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 153 AEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISTVVGednfldWGWRIpFFLALPLGIIGLYLRHALEETPAFQqhve 232
Cdd:cd17372 112 LEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLG------WRWLL-AFSSVPSSLLLVFYRWTPKTTLLLW---- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 233 kleqgdreglqdgpkVSFKEIATKHWRSLLTCIGLVISTNVTYYMLLT-YMPSYLSHNLHYSEDHGVLIIIAIMVGMLFV 311
Cdd:cd17372 181 ---------------VIWFGNAFAYYGVVLLTTELNNSHNVCGSKSDSdSGESPTEKQCRNSNDVDYRDVFIATFAEFPG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 312 QPIMGLLSDRFGRRP--FIILGSVALFALaiPAFILINSDVL-GLIFAGllmLAVILNCFIGVMASTlPAMFPTHIRYSA 388
Cdd:cd17372 246 LLISAAMIDRLGRKAsmASMLFTCCIFLL--LLLICQSPFILtVLLFGG---RACISAAFTVVYIYT-PEVYPTAVRALG 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 658547747 389 LAAAFNISVLIAGLTPTLAASLVESTQNLMMpAYYLMVIAVIGL 432
Cdd:cd17372 320 VGTGSSVGRIGAILCPFIAQVLVHGSQTIAL-LLFSVVCLVSAI 362
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
81-433 |
2.09e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 53.01 E-value: 2.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATIGiwaPILLLIckmaqGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17475 46 VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLL---VLLFLV-----GAGYGSVQPGGGRAIMRWFPPRE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 161 RGF-MGswldfgsI--AGFVMGAGVVVLISTVVgednFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVEKLEQG 237
Cdd:cd17475 118 RGLaMG-------IrqTGVPLGGALAAALLPPL----ALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESAST 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 238 DREGLqdgpKVSFKEIATkhWRSLLTCIGLVISTnvtyYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGL 317
Cdd:cd17475 187 LLRSL----KEVLRNRDV--WLIAIAGALLVAPQ----FALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 318 LSDRF--GRRPFIILGSVALFALAIPAFILINSDV-LGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFN 394
Cdd:cd17475 257 VSDRVfgGRRRPVLVITAAIAAAALLVLSLLSPGTpLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANT 336
|
330 340 350
....*....|....*....|....*....|....*....
gi 658547747 395 ISVLIAGLTPTLAASLVESTQNLMMPAYYLMVIAVIGLI 433
Cdd:cd17475 337 INFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAAL 375
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
62-444 |
2.80e-07 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 52.65 E-value: 2.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 62 SLQMIAALGTFSVPFLIrplGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLipSYAtigIWAPILLLICKMAQGFSV 141
Cdd:cd17357 48 DLLWSLIVSIFFIGGAI---GSFISAFLANRFGRKNGLLISNALLVVSSLLMFL--SKS---AKSPELLIFGRFLVGIAC 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 142 GGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAgVVVLISTVVGEDNfldwgWRIPFFLALPLGIIGLYLRHAL 221
Cdd:cd17357 120 GLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQ-VFGLPSVLGTETL-----WPYLLFFPGIPALLQLAALPFF 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 222 EETPAF-------------------------QQHVEKLEQGDREGLQDGpKVSFKEIATKHWRSLLTCIGLVISTNvtyy 276
Cdd:cd17357 194 PESPKFlliskgdeeeaekslkflrgieddvDQELEEIKKESEQMGDQK-QVSLMQLLRDPSLRLPLLLVLVVSAS---- 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 277 MLLTYMPSYLSHNLHYSEDHGVLIIIAIMV--GMLFVQPIMGLLS----DRFGRRPFIILG----SVALFALAIPAFILI 346
Cdd:cd17357 269 QQFSGINAIFFYSTFIFENAGFSPQLAEWAnlGIGIVNVLSTIVGpfliEKVGRRPLLLISlsvcAVALLLMSVFLFLSE 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 347 NSDVLGLIFAGLLMLAVIlnCF---IGVMASTLPA-MFPTHIRYSALAAAFNISVLIAGLTPTLAASLVEStqnlmMPAY 422
Cdd:cd17357 349 QNSWMSYGCIVAIFLFIF--FFaigLGPIPWFIGAeLFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSI-----GGGF 421
|
410 420
....*....|....*....|....*.
gi 658547747 423 YLMVIAVIGLITGLTMK----ETANR 444
Cdd:cd17357 422 VFIIFAIPCALFLLYLYrylpETKGR 447
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
81-410 |
2.99e-07 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 52.64 E-value: 2.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 81 LGGLFFGMLGDKYGRQKILAITIVImsistFCIGLIPSYATIGIWApiLLLICKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17356 60 FGALISSFLSDRIGRKKSIQIGCVI-----YIIGAIIQVAAIGKWY--QLIVGRIIAGLGVGFASVLVPVYQSEVAPKHI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 161 RGFMGSWLDFGSIAGFVMGAgvvvlISTVVGEDNFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVekleqgdre 240
Cdd:cd17356 133 RGTLVSLYQLAITIGILVAY-----CINYGTHKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRWLYRT--------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 241 glqdgpkvsFKEIATKHWRSLltciglvisTNVTYYMlltYMPSYLSHNLHYSEDHGVL---IIIAIMVGMLFVQPImgl 317
Cdd:cd17356 199 ---------ILGIMLQLFQQL---------TGINYFF---YYGTTIFQSTGLTGSSPLLtsiILYIVNFVSTIPGLF--- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 318 LSDRFGRRPFIILGSVALFAL-----AIPAFILINSDVLG--LIFAGLLMLAVILnCFIGVMASTL--------PAMFPT 382
Cdd:cd17356 255 FVDKFGRRTCLLIGAAGMSIClfiyaAVGVRYLIPNPQSGtsNKSAGNGMIVFIC-LFIFSFATTWgpiawvyvAEVFPL 333
|
330 340 350
....*....|....*....|....*....|..
gi 658547747 383 HIRY--SALAAAFN--ISVLIAGLTPTLAASL 410
Cdd:cd17356 334 RVRSkgMALATAFNwlWNFLISFFTPFIIGSI 365
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
72-414 |
3.73e-07 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 52.44 E-value: 3.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 72 FSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFcigLIPSYATIGIwapILLLICKMAQGFSVGGEYTGASIF 151
Cdd:TIGR00894 82 LSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISI---VIPWAAGGGI---ALVVFCRVIQGLAQGSVSPATHKI 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 152 VAEYSPDRKRGFMGSwldfGSIAGFVMGAGVVVLISTVVGEdnfLDWGWRIPFFLALPLGIIGLYLRHAL-----EETPA 226
Cdd:TIGR00894 156 IVKWAPPKERSRLLG----MSTSGFQLGTFIFLPISGWLCE---SWGGWPMIFYVFGIVGCAWSLLWFVFpaddpSIHPC 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 227 FQQHVEK-----LEQGDREGLQDGPkvsFKEIATkhWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYS-EDHGVL- 299
Cdd:TIGR00894 229 ISKFEKKyinssLQGQKGSTRQSLP---IKAIPK--SLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSgKENGLLs 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 300 ---IIIAIMVGMLFVQPIMGLLSDRFGRRP-----FIILGSVALFALAIPAFILINSDVLGLIFaglLMLAVILNCFIgv 371
Cdd:TIGR00894 304 slpYLFAWLCSIFAGYLADFLKSSKTLSLTaarkiFNGIGGLGPGIFAYALPYLSAAFYLTIII---LTLANAVSSGP-- 378
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 658547747 372 mastLPAMFPTHIRYSALAAAF-----NISVLIAGLTPTLAASLVEST 414
Cdd:TIGR00894 379 ----LAGVLINSLDLAPRFLGFikgitGLPGFIGGLIASTLAGNILSQ 422
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
274-441 |
5.09e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 51.83 E-value: 5.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 274 TYYMLLTYMPSYLsHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGsVALFALAIPAFILINSdvLGL 353
Cdd:cd17489 11 SFYLLLPVLPLYA-HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIG-LLIFALATLLYLLATS--VAL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 354 IFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNISVLIAGLTPTLAASLVeSTQNLMMPAYYLMVIAVIGLI 433
Cdd:cd17489 87 LLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLY-QHLGFAVLFIVAAVLALLALL 165
|
....*...
gi 658547747 434 TGLTMKET 441
Cdd:cd17489 166 LVFLVKDP 173
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
84-439 |
1.15e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 50.65 E-value: 1.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 84 LFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLICKMAQGFSvGGEYTGASIFVAEYSPDRKRGF 163
Cdd:cd17504 49 PILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPV--------LIAGRALQGIG-GAVFPLAFALVREEFPPERVPV 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 164 MGSWLDfgsiAGFVMGAGVVVLISTVVGEdnflDWGWRIPFFLALPLGIIGLYLrhaleetpafqqhvekleqgdreglq 243
Cdd:cd17504 120 AQGILS----ATFGIGAGIGLPLGGWIVQ----HLGWRWIFWTAAPVAVLLAAL-------------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 244 dGPKVSFKEIATKHWrsLLTCIGLVISTnVTYYMLLTYMPSYLSHNLHYSEDHGV----LIIIAIMVGMLFVQPIMGLLS 319
Cdd:cd17504 166 -VPLIDLRLLRRRNV--LLANITALLAG-FGMFMVFQLLPQLLQLPTPTGFGLGIteagLLLLPGALVMLIAGPLAGRLI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 320 DRFGRRPFIILGSVaLFALAIPAFILINSDVLGLIFAGLLM---LAVILNCFIGVMASTLPAMFP-------THIRYSAL 389
Cdd:cd17504 242 ARVGPRRVLLIGLV-ISAVGLLLLALLHSSLWALVVALLLIgigLGLAFASLPNIVVESVPPDRTgiatgmnTVLRTIGS 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 658547747 390 AAAFNIS-VLIAGLTPTLAASLVESTQNLMMPAYYLMVIAVIGLITGLTMK 439
Cdd:cd17504 321 AIGPAIAgAILTTYTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
71-363 |
1.81e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 49.96 E-value: 1.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 71 TFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSyatigIWApilLLICKMAQGFsVGGEYTGASI 150
Cdd:cd17391 41 AFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTN-----VWQ---LLILRLLQGV-FSGYVPNATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 151 FVAEYSPDRKRGFMGSWLDFGSIAGFVMGAgvvvLISTVVgEDNFldwGWRIPFFLALPL----GIIGLYLRHAleetpa 226
Cdd:cd17391 112 LIASQTPKEKSGWALGTLSTGVVAGTLIGP----LLGGFL-ADLF---GIRNVFFITGGLlflaFLLTLFFVKE------ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 227 fqqhvekleqgDREGLQDGPKVSFKEIatkhWRSlLTCIGLVISTNVTYYMLLT-------YMPSYLSHnLHYSEDHGVL 299
Cdd:cd17391 178 -----------DFKPVEKKKMVSTKEV----WNS-VPNPSLLISLFVTTFIIQLanqsiepILTLYIRQ-LMGDASNLAF 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 658547747 300 I---IIAIM-VGMLFVQPIMGLLSDRFGRRPFIILGSVALFALAIPAFILINSDVLGlIFAGLLMLAV 363
Cdd:cd17391 241 IsglVFSATgVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLG-ILRFLLGLAT 307
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
271-467 |
2.24e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 49.88 E-value: 2.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 271 TNVTYYMLLTYMPSYLSHnLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSVaLFALAIPAFILINSdV 350
Cdd:cd17325 8 DMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLL-LLAVSTLLFAFATS-Y 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 351 LGLIFAglLMLAVILNCFIGVMASTLPA-MFPTHIR---YSALAAAFNISVLIAgltPTLAASLVESTqNLMMPAYYLMV 426
Cdd:cd17325 85 WQLLLA--RFLQGLASAAVWPAAMALIAdIAPPEERgraMGIFSSAIGLGFLIG---PLLGGLLADAL-GYRAPFLVCAA 158
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 658547747 427 IAVIGLITGLTM-KETANRPLKGATPAASDIQEAKEILREHY 467
Cdd:cd17325 159 LALLALVLALLLlPEPRPPPNKRAVSAARLRSGLRLLLRDRR 200
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
250-445 |
4.44e-06 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 48.78 E-value: 4.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 250 FKEIATKHWRSLLTCIGLVIstnvtyYMLLTY------MPSYLS--HNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDR 321
Cdd:PRK15402 1 LSPLARLGRQALLFPLCLVL------FEFATYiandmiQPGMLAvvEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 322 FGRRPfIILGSVALFALAIPAFILINSdvlglI--FAGLLMLAVILNCFIGVMA-STLPAMF--PTHIRYSALAAafNIS 396
Cdd:PRK15402 75 IGRRP-VMLAGVAFFILTCLAILLAQS-----IeqFTLLRFLQGIGLCFIGAVGyAAIQESFeeADAIKITALMA--NVA 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 658547747 397 VLIAGLTPTLAASLVESTQNLMMpayyLMVIAVIGLIT--GL--TMKETANRP 445
Cdd:PRK15402 147 LLAPLLGPLVGAALIHVLPWRGM----FVLFAALAALSffGLwrAMPETAGRV 195
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
257-413 |
7.74e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.94 E-value: 7.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 257 HWRSLLTCIGLVISTNVTYYMLLTYMPsYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGsVALF 336
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAP-PLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG-LLLW 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658547747 337 ALAIPAFILINSdvLGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNISVLIAGLTPTLAASLVES 413
Cdd:COG2271 86 GLATLLFGFATS--FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
298-433 |
8.24e-06 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 48.39 E-value: 8.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 298 VLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSValfaLAIPAFIL------INSDVLGLIFAGLLMLAvilncfIGV 371
Cdd:cd06179 35 TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNL----LGVVGSIVagtaksVNMLIGGQALIGIGAGT------QGL 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 658547747 372 MASTLPAMFPTHIRYSALAAAFNISVLIAGLTPTLAASLVESTQNLMMPAYYLMVI----AVIGLI 433
Cdd:cd06179 105 GAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAGWRWIFYINAIfnalALILLF 170
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
73-168 |
1.09e-05 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 48.05 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 73 SVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLICKMAQGFSVGGEYTGASIFV 152
Cdd:TIGR01299 209 LIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGF--------FLFCRLLSGFGIGGAIPIVFSYF 280
|
90
....*....|....*.
gi 658547747 153 AEYSPDRKRGFMGSWL 168
Cdd:TIGR01299 281 AEFLAQEKRGEHLSWL 296
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
80-406 |
1.97e-05 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 46.92 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 80 PLGGLFFGMLGDKYGRQK-ILAITIVIMSISTFCIGLIP--SYATIGIWAPILLLICKMAQGFSvggeYTGASIFVAEYS 156
Cdd:pfam13347 51 PIVGHIIDRTRTRWGRRRpWLLLSAIILAVSFILLFTPPelGRAPLFIWLLATYILLRIAYTFF----EIPYWSLGPELT 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 157 PDRK-RGFMGSWLDFGSIAG---FVMGAGVVVLISTVVGEDNFLDWGWRIPFFLALPLGIIGLYL--RHALEETPAfqqh 230
Cdd:pfam13347 127 RDYDeRTSLTSYRSFFSVGGgllAAALAFPLVLILGGTGLERKGYRIFALIGAVLMLLGVIITAAgtKERVSMRSK---- 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 231 vEKLEQGDREGLQDGPKVSFKEiatKHWRSLLTCIGLV-ISTNVTYYMLLTYMPSYLSHNLHYSedhgvLIIIAIMVGML 309
Cdd:pfam13347 203 -EDTGQKEAGSLLDMLKEVFRN---RAFLILLASFLLAaLAMGVLNGLLLYYFRYVLGNGFAAS-----AFPLVFTIGAL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 310 FVQPIMGLLSDRFGRRPFIILGSVALFALAIPAFILINSDVLglifaGLLMLAVILNCFIGVMASTLPAMFPTHIRYSAL 389
Cdd:pfam13347 274 LGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTL-----LFLVLYIIIGFGYGSSFFLPWSMLADVVDYGEL 348
|
330
....*....|....*..
gi 658547747 390 AAAFNISVLIAGLTPTL 406
Cdd:pfam13347 349 RTGKRREGTFFAMWSFI 365
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
81-424 |
2.05e-05 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 46.99 E-value: 2.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 81 LGGLFFGMLGDKYGRQKILAITIVIMSIStfciGLIPSY-----ATIGIWAPILLL---ICKMAQGFSVGGEYTGASIFV 152
Cdd:PRK10077 70 IGGALGGYCSNRFGRRDSLKIAAVLFFIS----ALGSAWpefgfTSIGPDNTGYVPefvIYRIIGGIGVGLASMLSPMYI 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 153 AEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISTVvGEDNFL-DWGWRIPFFL-ALPLGIIGLYLrHALEETP---AF 227
Cdd:PRK10077 146 AEIAPAHIRGKLVSFNQFAIIFGQLVVYFVNYFIARS-GDASWLnTDGWRYMFASeAIPALLFLMLL-YFVPETPrylMS 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 228 QQHVEKLE------QGDREG---LQDgPKVSFKEIATKHWR-----SLLTCIGLVIST-------NVTYYmlltYMPSYL 286
Cdd:PRK10077 224 RGKQEQAEgilrkiMGNTLAtqaLQE-IKHSLDHGRKTGGKllmfgVGVIVIGVMLSVfqqfvgiNVVLY----YAPEIF 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 287 ShNLHYSEDHGVL-IIIAIMVGMLF-VQPIMGLlsDRFGRRPFIILGSValfALAIPAFILINSDVLGLIfaGLLMLAVI 364
Cdd:PRK10077 299 K-TLGASTDIALLqTIIVGVINLTFtVLAIMTV--DKFGRKPLQIIGAL---GMAIGMFSLGTAFYTQAP--GIVALLSM 370
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658547747 365 LNCFIGVMASTLPA-------MFPTHIRYSALAaafnisvlIAGLTPTLAASLVESTQNLMMPAYYL 424
Cdd:PRK10077 371 LFYVAAFAMSWGPVcwvllseIFPNAIRGKALA--------IAVAAQWIANYFVSWTFPMMDKNSWL 429
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
271-402 |
2.26e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.45 E-value: 2.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 271 TNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSVaLFALAIPAFILINSdv 350
Cdd:cd17329 11 NRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLL-LRALGFALLGFAHS-- 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 658547747 351 LGLIFAGLLMLAVILNCFIGVMASTLPAMFPTHIR---YSALAAAFNISVLIAGL 402
Cdd:cd17329 88 PWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRtraFSLLYWAINLGVAIGPL 142
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
170-411 |
2.89e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 46.44 E-value: 2.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 170 FGSIAGFVMGAGVVVLISTVVGEDNFLDWGWRIPFFLALplGIIGLYLrhaleetpAFQQHVEKLEQGDREGLQDGPKVS 249
Cdd:cd17332 144 FATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGII--GIILLLI--------CFFGTRERVVPPEEEKSKLPLLKS 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 250 FKEIatKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHySEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFII 329
Cdd:cd17332 214 LKAL--LKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLG-GRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFF 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 330 LGSVaLFALAIPAFILINSDVLGLIFAgllmLAVILNCFIGVMASTLPAMFP---------THIRYSALAAAFN-----I 395
Cdd:cd17332 291 IGLL-LAILGLLLLFFLPPGNLVLILV----LAVLAGIGYGGANLLPWAMLAdvidygelkTGKRREGIFYSVMtffrkL 365
|
250
....*....|....*.
gi 658547747 396 SVLIAGLTPTLAASLV 411
Cdd:cd17332 366 GLALAGALVGLILSLA 381
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
87-418 |
3.75e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 46.07 E-value: 3.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 87 GMLGDKYGRQKILAITIVIMSISTFcigLIPSYATIGIWApilLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGS 166
Cdd:cd17318 77 GYLAEKYGAKRVLGYSILITALLTL---LTPLAARGGYGA---LIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTS 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 167 wldfGSIAGFVMGAGVVVLISTVVGEdnflDWGWRIPFFLalpLGIIGL-------YLrhaleeTPAFqqhvekleqgdr 239
Cdd:cd17318 151 ----IAYSGSQFGTVIAMPLSGFLCE----SLGWPSIFYI---FGGLGLlwcllwfFL------VLPV------------ 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 240 eglqdgpkvsfkeiatkhWRSLLTCIGlvisTNVTYYMLLTYMPSYLSHNLHYS-EDHGVLIIIAIMVGMLFVQpIMGLL 318
Cdd:cd17318 202 ------------------WAIVVAHFG----HNWGFYTLLTELPTYMSDVLHFNiKSNGFLSSLPYLAMWICSI-VGGYL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 319 SDR----------FGRRPFIILGSV--ALFALAIPafiLINSDVLGLIFagLLMLAVILN--CFIGVMASTLpAMFPthi 384
Cdd:cd17318 259 ADWlrsrgilsttTVRKLFTSIGFLgpGVFLIALG---YLGSNATLAVV--FLTLSVGLSgaCYSGFLVNHL-DLAP--- 329
|
330 340 350
....*....|....*....|....*....|....*.
gi 658547747 385 RYS-ALAAAFNISVLIAG-LTPTLAASLVESTQNLM 418
Cdd:cd17318 330 NYAgTLMGITNTAATIAGiISPLIVGAIVKNDQTIG 365
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
299-441 |
5.49e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 43.02 E-value: 5.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 299 LIIIAIMVGMLFVQPIMGLLSDRFGRRPfIILGSVALFALAIPAFILINSdvLGLIFAGLLMLAVILNCFIGVMASTLPA 378
Cdd:TIGR00880 2 LLLAGYALGQLIYSPLSGLLTDRFGRKP-VLLVGLFIFVLSTAMFALSSN--ITVLIIARFLQGFGAAFALVAGAALIAD 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658547747 379 MFPTHIRysalAAAFNISVLIAGLTPTLAA---SLVESTQNLMMPAYYLMVIAVIGLITGL-TMKET 441
Cdd:TIGR00880 79 IYPPEER----GVALGLMSAGIALGPLLGPplgGVLAQFLGWRAPFLFLAILALAAFILLAfLLPET 141
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
81-206 |
5.68e-05 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 45.10 E-value: 5.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigIWAPILLLICkmaqGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17446 48 VGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSF----PIYCVFRFLT----GMALSGIVLNSVSLNVEWMPTRV 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 658547747 161 RGFMGSWLDFGSIAGFVMGAGVVVLIStvvgednflDWGW-----RIPFFL 206
Cdd:cd17446 120 RAVVGTLLGYCYTLGQLILAGVAYAIR---------DWRWlqlavSLPFFI 161
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
81-227 |
5.85e-05 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 45.17 E-value: 5.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigiwapILLLICKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17435 51 LASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSY--------TVLIVGRIAIGVSISLSSIATCVYIAEIAPQHR 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658547747 161 RGFMGSWLDFGSIAGFVMGAGVVVLISTVVGednfldwGWRIPFFLALPLGIIGLYLRHALEETPAF 227
Cdd:cd17435 123 RGLLVSLNELMIVIGILLAYISNYAFANVSN-------GWKYMFGLVIPLAALQAIAMYFLPPSPRF 182
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
81-213 |
6.22e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 43.02 E-value: 6.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLICKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:TIGR00880 13 IYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITV--------LIIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 658547747 161 RGFMgswldfgsIAGFVMGAGVVVLISTVVGEDNFLDWGWRIPFFLALPLGII 213
Cdd:TIGR00880 85 RGVA--------LGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALA 129
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
45-362 |
6.66e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 45.26 E-value: 6.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 45 GFVAYALGKVFFPGAdPSLQ------MIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPS 118
Cdd:cd17323 8 TFVVTFGSSIYSPAL-PQIAedfhvsEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 119 YATigiwapilLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRG-FMGSWldfgsIAGFVMGAGVVVLISTVVGEdnflD 197
Cdd:cd17323 87 IAM--------LIILRFLQGFFGSSPLAIGAGTIADLFTPEERGkAMGVY-----SLGPLLGPALGPIIGGFITQ----S 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 198 WGWRIPFFLALPLGIIGLYLRHALeetpafqqhvekleqgdreglqdgpkvsFKEIAtkhwrSLLTCIGLVistNVTYYM 277
Cdd:cd17323 150 LGWRWIFWFLAIISGFCLILIFLF----------------------------LPIVL-----LLGLYVGLV---YAILYL 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 278 LLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSValfalAIPAFILINSDVLGLIF-A 356
Cdd:cd17323 194 FLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKKNGGK-----PEPEARLPPAFIGAFLFpI 268
|
....*.
gi 658547747 357 GLLMLA 362
Cdd:cd17323 269 GLFIFG 274
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
297-383 |
6.92e-05 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 45.03 E-value: 6.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 297 GVLIIIA-IMVGMLFVQPIMGLLSDRFGRRPFIILGSV--ALFALAIPafiLINSDVLGLIFAgllMLAVILNCFIGvmA 373
Cdd:cd17396 36 GVAYVISgIGIGRLLTILFAGVLSDKFGRKPSVLLGMVlyALFFVGIL---FSPNLIIAYVFA---LLAGAANSFLD--T 107
|
90
....*....|...
gi 658547747 374 STLPAM---FPTH 383
Cdd:cd17396 108 GTYPALmeaFPKA 120
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
81-438 |
8.08e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.91 E-value: 8.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATIGIWapilLLICKMAQGFSvggeYTGASIFVAEYSPDRK 160
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIA----LVLTGFGGGLF----EPASEAMIADVTTPEN 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 161 RGFMGSWLDFGSIAGFVMGAgvvvLISTVVGEDNFldwgwrIPFFLALPLGIIGLYLRHALEETPAFQQHVEKLEQGDRE 240
Cdd:cd17329 122 RTRAFSLLYWAINLGVAIGP----LLGGLLLLYSF------RLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILR 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 241 GLQdgpkvsfkeiATKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSE-DHGVLIIIAIMVGMLFvQPIMGLLS 319
Cdd:cd17329 192 GYK----------IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGEsLLGLLLALNALLIVLL-QFPVARLV 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 320 DRFGRRPFIILGSVaLFALAIPAFILINSdvlgliFAGLLMLAVILNCFIGVMASTLPA----MFPTHIR---YSALAAA 392
Cdd:cd17329 261 ERFRLRKILMIGIL-LFAIGFAVLAFANT------LAVLILAMIVLTLGEMLVFPAVQTlvaaLAPPDKRgsyMGFYALA 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 658547747 393 FNISVLIAGltptLAASLVESTQNLMMPayyLMVIAVIGLITGLTM 438
Cdd:cd17329 334 WGLGRAIGP----LVGGLLLDLLGPGLP---WLILAALGLIAAALL 372
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
81-168 |
9.18e-05 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 44.91 E-value: 9.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLICKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17438 49 AGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYG--------AFLFCRLISGFGIGGSLPIVFAYFSEFLAREK 120
|
....*...
gi 658547747 161 RGFMGSWL 168
Cdd:cd17438 121 RGEHLSWL 128
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
73-168 |
9.50e-05 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 44.90 E-value: 9.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 73 SVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLICKMAQGFSVGGEYTGASIFV 152
Cdd:cd17440 41 SIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYG--------LFLFCRLLSGFGIGGAVPTVFSYF 112
|
90
....*....|....*.
gi 658547747 153 AEYSPDRKRGFMGSWL 168
Cdd:cd17440 113 AEVLAREKRGEHLSWL 128
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
71-434 |
1.04e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 44.52 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 71 TFSVPFLIrplGGLFFGMLGDKYGRQKILAITIvimsISTFCIGLIPSYATiGIWapiLLLICKMAQGFSVGgeYTGASI 150
Cdd:cd17331 43 TFSVLQLV---GGPLFGRFGDLFGPRAALVLSF----LSSALSYLLLAFAS-SVP---MLFLSRLPSVFMHA--MQAAQM 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 151 FVAEYSPDRKR----GFMGswLDFGsiAGFVMGAGVVVLISTVVGEdnfldwgwRIPFFLALPLGIIGLYLRHALEETPa 226
Cdd:cd17331 110 VVTDLTDPGERaaalGRLG--LSYG--IGMVVGSFLGGLLTKKFGE--------QAAALVAAVGSLLSIVLVILLIPSN- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 227 fqqhvEKLEQGDREGLQDGPKVSFKEIATKH-------WRSLLTCIGLVISTNVTYYMLltymPSYLSHNLHYSEDHGVL 299
Cdd:cd17331 177 -----TKSKREKEAKESASPPSVFNLKEILRllrlpgvAFLLLVKLLSGLPIGMFQSMF----SLVAMDFFGLTPEENGY 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 300 IIIAIMVGMLFVQPI-MGLLSDRFGRRpFIILGSVALFALAIPAFILINSDVLGLIFAGLLMLA-VILNCfigVMASTLP 377
Cdd:cd17331 248 LMSYAGVLGMVVQGLlVGPLTKRFGER-SLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGgSVLYT---VITSLLT 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 658547747 378 AMFPTHIRYSALAAAFNISVLIAGLTPTLAASLVestQNLMMPAYYLMVIAVIGLIT 434
Cdd:cd17331 324 KAVPPEDTGTALGLSHALFSLVRTVSPTIGGALL---QAYGFPSFGLLGAAINGLLT 377
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
84-371 |
1.78e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 43.83 E-value: 1.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 84 LFFGMLGDKYGRQKILAITIVIMSISTFCIGLI-PSYATigiwapilLLICKMAQGFsVGGEYTGASIFVAEYSPDRKRG 162
Cdd:TIGR00886 55 IILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSV--------LLLIRLFIGI-AGGSFASCMPWISFFFPKKIQG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 163 ----FMGSWLDFG-SIAGFVMGAGVVVLISTvVGEDNFLDWGWRIPFFLALPLGIIGLYLRHALEETPAfqqhvekleqG 237
Cdd:TIGR00886 126 talgLAAGWGNMGgGVAQFVMPPIIGSLIFG-GGQPAHLAWGWAFVIVPAGILLLPALLIFFVGADTPP----------G 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 238 DREGLQDGPKVSFKEIATKHwrslltciglvistnvTYYMLLTYMPSY------------LSHNLHYSEDHGVLIIIAIM 305
Cdd:TIGR00886 195 KPATGKLSFKEALKVFGNRH----------------TWILALLYSVTFgsflgvssifamLFKDQFGLSKVQAGAYASLG 258
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658547747 306 VGM-LFVQPIMGLLSDRFGRRpfiILGSVALFALAIPAFILINSDVLGLIFAGLLMLAVILNCFIGV 371
Cdd:TIGR00886 259 GFLgSLARPAGGAISDRLGGA---RKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALFFFAGA 322
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
23-215 |
2.34e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.36 E-value: 2.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 23 LRKAITAASLGNAMEWFDF-GVYGFVAYALGKVFFPGADPSLQMIAALGTFSVPflirplGGLFFGMLGDKYGRQKILAI 101
Cdd:cd17316 175 LRRRTLLLILLWFFISFGYyGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALV------GALIAGLLSDRIGRKKTLVI 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 102 TIVIMSIstfcigLIPSYATIGIWAPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAG 181
Cdd:cd17316 249 GLILSGI------LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPP 322
|
170 180 190
....*....|....*....|....*....|....
gi 658547747 182 VVVLISTVVGednfldwGWRIPFFLALPLGIIGL 215
Cdd:cd17316 323 LIALLLASTG-------GTGVPALILALLAIVAL 349
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
69-353 |
2.71e-04 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 43.07 E-value: 2.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 69 LGTFSVPFLIRPLGGLFF-GMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatIGIWAPILLLICKMAQGFSvggEYTG 147
Cdd:cd17342 65 LGVLDTIFLFSYAIGLFIsGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEW--LHFYNKYLYCILWVLNGLL---QSTG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 148 ASIFVAeyspdrkrgFMGSWldFGSIA-GFVMG-----AGVVVLISTVVGEdNFLDWGWRIPF-FLALPLGIIGLYLRHA 220
Cdd:cd17342 140 WPCVVA---------IMGNW--FGKSSrGFVLGlwsacASVGNIIGALLAS-SVLDYGYEYAFlVTSSLLFAGAIVVFFG 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 221 LEETPafqqhvekleqgdreglqdgPKVSFKEIAtkhwrslLTCIGLVistNVTYYMLLTYmpsYLSHNLHYSEDHGVLI 300
Cdd:cd17342 208 LLSSP--------------------PGVIPYSLA-------YACLKLV---NYSFFFWLPF---YLSNNFHWKESEADQL 254
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 658547747 301 IIAIMVGMLFVQPIMGLLSDRFGRR-----PFIILGSVALFALA-IPAFILINSDVLGL 353
Cdd:cd17342 255 SIWYDVGGIIGGIVAGYISDRMGSRspvvvVMLLLAIPSLFVYShSPSDKVLNAFVMTI 313
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
45-378 |
4.53e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 42.31 E-value: 4.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 45 GFVAYALGkVFFPGAD-PSLQMIAALGTFSVPFLI------RPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIP 117
Cdd:cd17333 4 SFFSNGLT-DALLGILgPSLEEAFNLNVADVSVIFssqnagYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 118 SYatigiwapILLLICKMAQGFSVGGEYTGASIFVAEYSPdRKRGFMGSWLDFGsiagFVMGAGVVVLISTVVGeDNFLD 197
Cdd:cd17333 83 SI--------YLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGF----FGLGALIGPLIATSLL-TSELS 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 198 WGW--RIPFFLALPLGIIGLYLRhaleetpaFQQHVEKLEQGDREGLQDGPKVSFKEIATKHWRSLLTCIGLVISTNVty 275
Cdd:cd17333 149 WSWayLIIGLIYLLLAILILLTL--------FPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAF-- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 276 ymlLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSVALFALAIpaFILINSDVLGLIF 355
Cdd:cd17333 219 ---SSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLL--ILLLAPTLVVGLV 293
|
330 340
....*....|....*....|....*.
gi 658547747 356 AGL---LMLAVILNCFIGVMASTLPA 378
Cdd:cd17333 294 ATAllgLFMAALFPTILSLGISNLPY 319
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
65-214 |
5.03e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 42.26 E-value: 5.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 65 MIAALGTFSVpflirpLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPsyatigiWAPILLLICKMAQGFSVGGE 144
Cdd:cd17355 250 ALALIGLFNI------VGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLP-------FPPLALLLFAALFGLGWGAT 316
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 145 YTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISTVVGednfldwGWRIPFFLALPLGIIG 214
Cdd:cd17355 317 VPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG-------SYTAAWALAVALGLIA 379
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
277-433 |
5.21e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 5.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 277 MLLTYMPSYLSHNLHYSEDHGV--LIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSVA------LFALAIPAFILINS 348
Cdd:cd17330 14 IVFPVLPFYVREFNKLGASGYYvgLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGsavsyvLLGLSRNLWLLFLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 349 DVLGLIFAGLlmLAVILNCFIGVMASTLPAmfpthIRYSALAAAFNISVLIAgltPTLAASLVeSTQNLMMPAYYLMVIA 428
Cdd:cd17330 94 RFLDGLTGGN--VSVAQAYIADITDEEERA-----KAFGIISAAFGLGFILG---PALGGFLS-TPYGYALPFLVAAALA 162
|
....*
gi 658547747 429 VIGLI 433
Cdd:cd17330 163 LLNLV 167
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
81-168 |
5.38e-04 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 42.32 E-value: 5.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLICKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17439 49 VGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGT--------FLFCRLLSGVGIGGSIPIVFSYFSEFLAQEK 120
|
....*...
gi 658547747 161 RGFMGSWL 168
Cdd:cd17439 121 RGEHLSWL 128
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
261-407 |
5.84e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 42.18 E-value: 5.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 261 LLTCIGLVISTNVTYYMLLTYMPSyLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPfIILGSVALFALAI 340
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPA-IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRP-VLLAGLLLFILAS 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658547747 341 PAFILINSdvlgliFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNISVLIAGLTPTLA 407
Cdd:cd17320 79 LLCALASS------IEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALA 139
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
44-180 |
5.93e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.15 E-value: 5.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 44 YGFVAYALGKVFFPGADPSLQMIAALGTFSvpflirpLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSyatig 123
Cdd:cd17370 219 FAFLILRAQELGLSAALIPLLYALFNLVYA-------LAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSS----- 286
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 658547747 124 iwaPILLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGS-----IAGFVMGA 180
Cdd:cd17370 287 ---LWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVgigwlLASLIAGY 345
|
|
| MFS_NIMT_like |
cd17409 |
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of ... |
160-436 |
7.73e-04 |
|
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli 2-nitroimidazole transporter (NIMT), also called YeaN, and similar proteins. NIMT confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. The NIMT-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340967 [Multi-domain] Cd Length: 374 Bit Score: 41.87 E-value: 7.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 160 KRGFMGSWLDFGSIAGFVMGAGVVVLISTVVGEDNFLDWGWR--IPFFLALPLGIIGLYLrhaleetPAFQQHveKLEQG 237
Cdd:cd17409 112 KRDFPARVATLTGAYALTMGVGAALGSALVVPLAQVLAFGWQlaLGAFLVFPLVAALIWL-------PQLRRH--TSPAA 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 238 DREGLQDGPKVsfkeiatkhWRSLLTC-IGLVISTN-VTYYMLLTYMPSYLSHNLHYSED----HGVLiIIAIMVGMLFV 311
Cdd:cd17409 183 DTAKPPHGGSV---------WRSPLAWqVTLFLGLNsFIYYVLVGWLPSILTDAGYSAAQagslHGLL-QLATAVPGLLL 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 312 QPIMGLLSD-RFGRRPFIILGSVALFALAI-PAFILINSDVLGLIFAGLLMLAVIlncFIGVMASTlpamfpthirySAL 389
Cdd:cd17409 253 IPVLARMKDqRLLAVLVSLLGAVGLIGLLLaPSLAILWVILFGFGSGAGFILGLA---FIGLRTSS-----------AHQ 318
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 658547747 390 AAAFN-----ISVLIAGLTPTLAASLVESTQNLMMPAYYLMVIAVIGLITGL 436
Cdd:cd17409 319 AAALSgmaqcVGYLLAATGPMLVGALHDLTGSWSVPLLLCAALALLMAIFGL 370
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
295-357 |
8.99e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 41.47 E-value: 8.99e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658547747 295 DHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILgsvALFALAIPAFILINSDVLGLIFAG 357
Cdd:cd17388 38 THYGVLLALYALMQFIFAPILGALSDRFGRRPVLLL---SLAGAALDYLLMAFAPTLWWLYLG 97
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
265-382 |
1.00e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 41.33 E-value: 1.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 265 IGLVIST--NVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSVALFALAIPA 342
Cdd:cd17337 212 IGGIVRIinTLSQFGFPVFMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWFGGVGCAISTLL 291
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 658547747 343 FILInsdvlGLIFAGLLMLAVILNCFIGVMAST---LPAMFPT 382
Cdd:cd17337 292 FYYV-----PQLFGHNYWAALIAAILFGIGLAGfvpLSALMPS 329
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
261-433 |
1.08e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 41.38 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 261 LLTCIGLVIsTNVTYYMLLTYMPSYLShNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFG-RRPFIILGSVALFALA 339
Cdd:cd17352 186 VLLALGVSF-AMLGFFVPFVYLPSYAK-SLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRiGRLYLYIFTLLILGLS 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 340 IPAFILINSdvlgliFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAFNISVLIAGLT----PTLAASLVESTQ 415
Cdd:cd17352 264 LLAFPLATT------YVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAalvgPPIAGLLRDYTG 337
|
170
....*....|....*...
gi 658547747 416 NLMMPAYYLMVIAVIGLI 433
Cdd:cd17352 338 DYDAAFYFCGACLLLSGV 355
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
59-358 |
1.97e-03 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 40.63 E-value: 1.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 59 ADPSLQMIAALGTF--SVPFLIRPLGGLFFGMLGDKYGRQkilaITIVIMSIStFCIGLIPSYATIGIWapiLLLICKMA 136
Cdd:cd17433 32 ADPALRLDDAAASWfgSVVTLGAAAGGVLGGWIVDRAGRK----LSLMLCSVP-FIAGFTVITAAQNVW---MLYVGRLL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 137 QGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGfVMGAGVVVListvvgednFLDWGWrIPFFLALPLGIIgLY 216
Cdd:cd17433 104 TGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIG-IMGAYLAGL---------VLDWRW-LAVLGSIPPTLM-LL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 217 LRHALEETPAF---QQHVEKLE------QGDREGLQDGP---KVSFKEIATKHWRSLLTCIGLVISTNVTYYMLLTYMPS 284
Cdd:cd17433 172 LMCFMPETPRFlltQHRRQEAMaalrflRGPDQGWEWECigiEQSFHLEEQSFSLALLKQPGIYKPLIIGVSLMAFQQLT 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 285 YLSHNLHYSE---------DHGVLIIIAIMVGMLFVQpIMGLLSDRFGRRPFIILGSVALfALAIPAFILINSDVLGLIF 355
Cdd:cd17433 252 GINAVMFYAEtifeeakfkDSSVASVIVAAIQVLFTA-VAALIMDRAGRKVLLVLSGVVM-VFSTAAFGWLAVGSMGFFI 329
|
...
gi 658547747 356 AGL 358
Cdd:cd17433 330 AGF 332
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
29-398 |
2.37e-03 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 40.31 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 29 AASLGNAMEWFDFGVYGFVAY--ALGKVFFPG----------------ADPSLQmiaaLGTfSVPFLIRPLGGLFFGMLG 90
Cdd:cd17361 1 VAALGGLIFGYDIGISGGVTSmdPFLEKFFPSvyekkkgasennyckyDDQLLQ----LFT-SSLYLAGLVASLLASYVT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 91 DKYGRQkilaITIVIMSIStFCIGLIPSYATIGIWApilLLICKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMgswldf 170
Cdd:cd17361 76 RKWGRK----PSMLIGGVL-FLVGAALNAAAQNIAM---LIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGAL------ 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 171 gsIAGFVMGAGVVVLISTVV--GEDNFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQhvekleqgdreglqdgpkv 248
Cdd:cd17361 142 --NIGFQLAITIGILIANLInyGTSKIKPNGWRLSLGLAAVPALILLLGSLFLPETPNSPQ------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 249 sfkeiatkhwrsLLTCIGLVISTNVT-YYMLLTYMPSYLShNLHYSEDhGVLIIIAIMVGMLFVQPIMG-LLSDRFGRRP 326
Cdd:cd17361 201 ------------LVIAILIPFFQQLTgINVIMFYAPVLFQ-TLGFGSD-ASLISAVITGAVNVVSTLVSiYLVDRFGRRF 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 327 FIILGSVALFA--LAIPAFILINSDVLGLIFAGLLMLAVILNCFI--------GVMASTLPA-MFPTHIRysalAAAFNI 395
Cdd:cd17361 267 LLLEGGVQMLAsqVAIGILLAVKFGDGGELPKAYAIAVVVLICLYvaafawswGPLGWLVPSeIFPLETR----SAGQSL 342
|
...
gi 658547747 396 SVL 398
Cdd:cd17361 343 TVA 345
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
261-403 |
2.40e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 40.23 E-value: 2.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 261 LLTCIGLVISTNVTYYM-LLTYmpsyLSHNLHYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPfIILGSVALFALA 339
Cdd:cd17324 3 ALALAAFAIGTTEYVIQgLLPD----IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRR-LLLVLLLLFILG 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 658547747 340 IPAFILINSdvlgliFAGLLMLAVILNCFIGVMASTLPAMFPTHIRYSALAAAfnISVLIAGLT 403
Cdd:cd17324 78 NLLAALAPS------FALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRA--IGLVFSGLT 133
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
81-168 |
3.52e-03 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 39.78 E-value: 3.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLICKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17363 49 VGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGF--------FLFCRLLSGIGIGGSIPIVFSYFAEFLAREK 120
|
....*...
gi 658547747 161 RGFMGSWL 168
Cdd:cd17363 121 RGEHLSWL 128
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
291-437 |
4.78e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 39.23 E-value: 4.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 291 HYSEDHGVLIIIAIMVGMLFVQPIMGLLSDRFGRRPFIILGSvALFALAIPAFILINSdvLGLIFAGLLMLAVILNCFIG 370
Cdd:cd17333 27 NLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGL-LLISLALALIFATPS--IYLFVVLMFLAGLGAGILDT 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 658547747 371 VMASTLPAMFP--THIRYSALAAAFNISVLIaglTPTLAASLVESTQNLmmpAYYLMVIAVIGLITGLT 437
Cdd:cd17333 104 GANTFVGALFEesSATRLNVLHGFFGLGALI---GPLIATSLLTSELSW---SWAYLIIGLIYLLLAIL 166
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
73-422 |
4.97e-03 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 39.03 E-value: 4.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 73 SVPFLIRPLGGLFFGMLGDKYGRQKILAITIVImsisTFCIGLIPSYATIGIWapilLLICKMAQGFSVGGEYTGASIFv 152
Cdd:cd17441 41 SVVFIGMMLSSSLWGNISDQYGRKTGLKISVLW----TLYYGILSAFAPIYSW----ILVLRGLVGFGIGGVPQSVTLY- 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 153 AEYSPDRKRGFMGSWLDfgsiAGFVMGAGVVVLISTVVGEdnflDWGWRIPFFL-ALPLGIIGLyLRHALEETPAFQQHV 231
Cdd:cd17441 112 AEFLPMKSRAKCILLIE----VFWALGTVFEVLLAVFVMP----TLGWRWLLILsALPLLIFAV-LCFWLPESARYWTTI 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 232 ---------------------EKLEQGDREGLQDGPKVSFKeiatkhwrSLLTCIGLvistNVTYYMLLtympsyLSHNL 290
Cdd:cd17441 183 llwfiwfsnafsyyglvllttELFQAGDVCSGSSGKKVEGK--------CSLECEYL----TTSDYMDL------LWTTL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 291 hySEDHGVLIIIAIMvgmlfvqpimgllsDRFGRRPFIILGSVALFALAIPAFILINSDVLGLIFagLLMLAVILNCFIG 370
Cdd:cd17441 245 --SEFPGLLVTLWII--------------DRFGRKKTMALCFFVFSFCTLLLFSCVGRFSLTVLL--FIARAFISGGFQA 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 658547747 371 VMASTlPAMFPTHIRYSALAAAFNISVLIAGLTPTLAASLVESTQNLMMPAY 422
Cdd:cd17441 307 AYVYT-PEVYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTLSVY 357
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
81-165 |
6.44e-03 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 38.87 E-value: 6.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigiwapILLLICKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17379 48 IGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY--------PWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKY 119
|
....*
gi 658547747 161 RGFMG 165
Cdd:cd17379 120 RRTVG 124
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
305-339 |
6.99e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 38.72 E-value: 6.99e-03
10 20 30
....*....|....*....|....*....|....*
gi 658547747 305 MVGMLFVQPIMGLLSDRFGRRPFIILGsVALFALA 339
Cdd:PRK11043 51 LAGFALGQLLWGPLSDRYGRKPVLLAG-LSLFALG 84
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
84-402 |
8.47e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 38.30 E-value: 8.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 84 LFFGMLGDK-YGRQKILAITIVIMSISTFCIGLIPSYATIGIWAPILLLI--CKMAQGFSVGGEYtgasifvAEYSPDRK 160
Cdd:cd17471 50 QWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLgaAAFPQLFALAREY-------ADRSSGRD 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 161 RGFMGSWLDFGSIAGFVMGAGVVVLISTVVG-EDNFLdwgwripfFLALPLGIIGLYLRHALEETPAFQQHVEKleqgdr 239
Cdd:cd17471 123 ATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGfTGLFL--------LAALLYLVVALLVLFLLPSVKPPAQKATP------ 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 240 eglqdgPKVSFKEIATKHWRSLLTCIGLVISTNVTYymlLTYMPSYLSHNLHYSEDHgvliiIAIMVGM--LFVQPIM-- 315
Cdd:cd17471 189 ------ASSLVKAPVNRRLLLLFAAFTLLFAANSMY---IIAMPLYVTNELGGSESW-----VGLLFGLaaALEIPIMll 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547747 316 -GLLSDRFGRRPFIILGSVALFALaipafilinsdVLGLIFAG---LLMLAVILN-CFIGVMA----STLPAMFPTHIRY 386
Cdd:cd17471 255 aGLLAKRFGKRRLLLAGFLAGVLF-----------YLGLALATslwQLIALQLLNaIFIGITAglgiSYFQDLMPGQPGL 323
|
330
....*....|....*...
gi 658547747 387 SA--LAAAFNISVLIAGL 402
Cdd:cd17471 324 ATtlYSNASRIGSLLGGL 341
|
|
| |
