|
Name |
Accession |
Description |
Interval |
E-value |
| actP |
PRK09395 |
cation/acetate symporter ActP; |
1-549 |
0e+00 |
|
cation/acetate symporter ActP;
Pssm-ID: 236495 Cd Length: 551 Bit Score: 986.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 1 MKRVLTALAATLPFAAHAADAITGEVQRQPTNWQAIVMFLIFVLLTLYITYWASKRVRSRNDYYTAGGNITGFQNGLAIA 80
Cdd:PRK09395 2 MKRLLTALAALLPAAAAAADAISGEVEKQPTNWQAIIMFLIFVVFTLGITYWAAKRTRSASDFYTAGGGITGFQNGLAIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 81 GDFMSAASFLGISALVYTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRTLSACGSLVVVAL 160
Cdd:PRK09395 82 GDYMSAASFLGISALVFTSGYDGLIYSIGFLVGWPIILFLIAERLRNLGKYTFADVASYRLKQGPIRTLSACGSLVVVAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 161 YLIAQMVGAGKLIELLFGLNYHVAVVLVGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFTE 240
Cdd:PRK09395 162 YLIAQMVGAGKLIQLLFGLNYHVAVVLVGVLMMVYVLFGGMLATTWVQIIKAVLLLSGATFMAFMVMKHVGFSFENLFSE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 241 AMAVHPKGEAIMSPGGLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAI 320
Cdd:PRK09395 242 AVAVHPKGLAIMGPGGLVKDPISALSLGLALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAI 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 321 MLVGANPAFKDAAGALIGGNNMAAVHLADAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKG-ASER 399
Cdd:PRK09395 322 VLVGTNPEFKDAAGALIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIKKGkATER 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 400 DELKVSKITVLVLGVVAILLGILFEKQNIAFMVGLAFSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLLTAVILMILG 479
Cdd:PRK09395 402 DELRVSKITTLVLGVVAIILGILFEKQNIAFMVGLAFAIAASANFPVLLLSMYWKGLTTRGAVIGGWLGLISAVVLMILS 481
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 480 PTIWVQILGHASAIFPYEYPALFSIAVAFIGIWFFSATDNSPEGNLEREKFRAQFIRSQTGLGVEQGRAH 549
Cdd:PRK09395 482 PTVWVDILGHEKAIFPYEYPALFSMPLAFVGIWFFSITDNSARAKREREAFRAQFVRSQTGIGASGASAH 551
|
|
| symport_actP |
TIGR02711 |
cation/acetate symporter ActP; Members of this family belong to the Sodium:solute symporter ... |
2-549 |
0e+00 |
|
cation/acetate symporter ActP; Members of this family belong to the Sodium:solute symporter family. Both members of this family and other close homologs tend to be encoded next to a member of pfam04341, a set of uncharacterized membrane proteins. The characterized member from E. coli is encoded near and cotranscribed with the acetyl coenzyme A synthetase (acs) gene. Proximity to an acs gene was used as one criterion for determining the trusted cutoff for this model. Closely related proteins may differ in function and are excluded by the high cutoffs of this model; members of the family of phenylacetic acid transporter PhaJ can score as high as 1011 bits. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 131758 Cd Length: 549 Bit Score: 917.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 2 KRVLTALAATLPFAAHAADAITGEVQRQPTNWQAIVMFLIFVLLTLYITYWASKRVRSRNDYYTAGGNITGFQNGLAIAG 81
Cdd:TIGR02711 1 KRVLLLLLATLPFLAWAADAISGAVERQPLNIQAIIMFLLFVGFTLYITYWASKKTRSRSDYYTAGGNITGFQNGLAIAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 82 DFMSAASFLGISALVYTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRTLSACGSLVVVALY 161
Cdd:TIGR02711 81 DYMSAASFLGISALVYTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQRPIRILSACGSLVVVALY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 162 LIAQMVGAGKLIELLFGLNYHVAVVLVGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFTEA 241
Cdd:TIGR02711 161 LIAQMVGAGKLIELLFGLNYHVAVVLVGILMVMYVLFGGMLATTWVQIIKAVLLLFGATFMAFMVMKSVGFSFNTLFKEA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 242 MAVHPKGEAIMSPGGLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIM 321
Cdd:TIGR02711 241 MAVHPKGVAIMSPGGLVSDPISALSLGLGLMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFMGYFYILTFIIGFGAIL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 322 LVGANPAFKDAAGALIGGNNMAAVHLADAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKG-ASERD 400
Cdd:TIGR02711 321 LVSANPEFKDATGALIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIKKGkATERD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 401 ELKVSKITVLVLGVVAILLGILFEKQNIAFMVGLAFSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLLTAVILMILGP 480
Cdd:TIGR02711 401 ELRVSKITVLILGVIAIGLGILFENQNIAFMVGLAFSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLITAVVLMILGP 480
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 697051813 481 TIWVQILGHASAIFPYEYPALFSIAVAFIGIWFFSATDNSPEGNLEREKFRAQFIRSQTGLGVEQGRAH 549
Cdd:TIGR02711 481 TIWVQILGHEKPIYPYEYPALFSMIVAFIGIWFFSITDNSETGAQERELFRAQFIRSQTGLGASQGRAH 549
|
|
| PRK12488 |
PRK12488 |
cation/acetate symporter; |
2-549 |
0e+00 |
|
cation/acetate symporter;
Pssm-ID: 237114 [Multi-domain] Cd Length: 549 Bit Score: 752.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 2 KRVLTALAATLPFAAHAADAITGEVQRQPTNWQAIVMFLIFVLLTLYITYWASKRVRSRNDYYTAGGNITGFQNGLAIAG 81
Cdd:PRK12488 1 MKLLLPLALLLHSGALLASPALDAGQRQPLNWTAIGMFMVFVLFTLGITRWAARRTRSASDFYTAGGGLTGMQNGLAIAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 82 DFMSAASFLGISALVYTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRTLSACGSLVVVALY 161
Cdd:PRK12488 81 DMISAASFLGISAMMFMNGYDGLLYALGVLAGWPIILFLIAERLRNLGKYTFADVVSYRLAQGPVRLTAAFGTLTVVLMY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 162 LIAQMVGAGKLIELLFGLNYHVAVVLVGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFTEA 241
Cdd:PRK12488 161 LVAQMVGAGKLIELLFGISYLYAVVIVGALMVLYVTFGGMLATTWVQIIKAVLLLSGTSFMAFMVLKHFGFSTEAMFASA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 242 MAVHPKGEAIMSPGGLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIM 321
Cdd:PRK12488 241 VAVHAKGQAILAPGGLLSNPIDAISLGLGMMFGTAGLPHILMRFFTVSDAREARKSVLYATGFIGYFYLLIIVVGFGAIV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 322 LVGANPAFKDAAGALIGGNNMAAVHLADAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKG-ASERD 400
Cdd:PRK12488 321 MVGTEPSYRDAGGKIIGGGNMVAVHLAQAVGGNLFLGFISAVAFATILAVVAGLALSGASAVSHDLYACVIRKGqASEAQ 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 401 ELKVSKITVLVLGVVAILLGILFEKQNIAFMVGLAFSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLLTAVILMILGP 480
Cdd:PRK12488 401 EMRVSKIATLGIGLLAVVLGLMFESQNIAFLSGLVLAIAASVNFPVLFLSMFWKGLTTRGAVAGSYAGLVSAVVLVVLGP 480
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 697051813 481 TIWVQILGHASAIFPYEYPALFSIAVAFIGIWFFSATDNSPEGNLEREKFRAQFIRSQTGLGVEQGRAH 549
Cdd:PRK12488 481 AVWVNVLHNATALFPYSNPALFSMSLAFLSAWVFSVTDRSERAVAERGRYLAQFVRSMTGIGAAGASKH 549
|
|
| ActP |
COG4147 |
Na+(or H+)/acetate symporter ActP [Energy production and conversion]; |
24-547 |
0e+00 |
|
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
Pssm-ID: 443318 Cd Length: 526 Bit Score: 702.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 24 GEVQRQPTNWQAIVMFLIFVLLTLYITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDG 103
Cdd:COG4147 3 ALLEQLGMNLLAIGIFLVFVTFTLYITIWAARRTKSTSDFYVAGRGVTGVQNGLAIAGDYMSAASFLGIAGLIALSGYDG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 104 LIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRTLSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHV 183
Cdd:COG4147 83 LIYSIGWLVGYVLLLLLLAEYLRNFGKFTVPDFLGDRFYSRPARLVAAISTLVVSFFYLIAQMVGAGVLISLLLGVDYEV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 184 AVVLVGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFTEAMAVHPKGEAIMSPGGLVKDPIS 263
Cdd:COG4147 163 AVVIVGVLMIVYVVLGGMKGTTWVQIIKAVLLIFAYTVPAVLVLAQFGFNPLPLLAKAAEVHDLGAAYLEPGGLVKSPLD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 264 ALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPAFKDA--AGALIGGNN 341
Cdd:COG4147 243 FISLGLALMLGTAGLPHILMRFFTVPDAKEARKSVGWALGFIGLFYLTAPALGFGARALVGPLPEWFDTglIGAADGGGN 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 342 MAAVHLADAV-GGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKGASERDELKVSKITVLVLGVVAILLG 420
Cdd:COG4147 323 MAVLALAEIAgGGNWLLGLVAAGAFATILAVVAGLLLAIASAISHDLYANVIKGKATEKEELRVARIAAVVIGVVAILLG 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 421 ILFEKQNIAFMVGLAFSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLLTAVILMILGPTIWVqiLGHASAIFPYEYPA 500
Cdd:COG4147 403 INAPPQNVAFLVALAFALAASANFPVLLLSIFWKRFNTRGAVAGMLVGLISALVLIVLSPFVWV--LGVDAALFPLENPG 480
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 697051813 501 LFSIAVAFIGIWFFSATDNSPEGNlEREKFRAQFIRSQTGLGVEQGR 547
Cdd:COG4147 481 LVSMPLGFLVAIVVSLLTPEPPAE-DQELVEEQEVRSPTGIGAAKAS 526
|
|
| SLC5sbd_u4 |
cd11480 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
36-515 |
0e+00 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271374 Cd Length: 488 Bit Score: 572.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 36 IVMFLIFVLLTLYITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLGFLVGWP 115
Cdd:cd11480 1 IGLFFVFVTITLYITIWAARRTRSTSDFYVAGRGVPPVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLAYAIGWTGGYV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 116 IILFLIAERLRNLGRYTFADVASYRLKQGPIRTLSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHVAVVLVGVLMVMY 195
Cdd:cd11480 81 LLLLLVAEPLRNFGKYTVPDFLGARLGSRPVRLVAAVSTLVISFFYLVAQMVGAGLLLSLLLGIPYEVGVVVVGALMIVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 196 VLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGF-----SFNNLFTEAMAVHPKGEAIMSPGGLVKDPISALSLGLG 270
Cdd:cd11480 161 VVLGGMRATTWVQIIQYVLLLGAFLVPAILVLARFGGnplgaGPGLLGLAAAAASGAGEAYLAPGLLLTDPLDVISLTLA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 271 LMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPAFKDAAGALIGGNNMAAVHLADA 350
Cdd:cd11480 241 LMLGTAGLPHVLMRFYTVPDARAARKSVVWALGFIGLFYLLAPALGFGARALVGPDVIGAPIAGELDGGGDMAVLLLPEI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 351 VG-GNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKGASERDELKVSKITVLVLGVVAILLGILFEKQNIA 429
Cdd:cd11480 321 AGlGDLLLALVAAGAFAAILATVAGLLLAAASALAHDLYAGVIRPGASERREVRVARIAAVVVGVIAILLALLFPPQNVA 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 430 FMVGLAFSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLLTAVILMILGPTIWVQILGHASAIFPYEYPALFSIAVAFI 509
Cdd:cd11480 401 FLVALAFAIAASAFFPVLVLGIFWRRFTTRGAIAGMLVGLLVSLVLIVLSPAVSGAPPGHDFAGFPLTNPGLVSVPLGFL 480
|
....*.
gi 697051813 510 GIWFFS 515
Cdd:cd11480 481 VAIVVS 486
|
|
| SSF |
pfam00474 |
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ... |
63-468 |
2.83e-133 |
|
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.
Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 393.63 E-value: 2.83e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 63 YYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLK 142
Cdd:pfam00474 1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRFG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 143 QGPI-RTLSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHVAVVLVGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASF 221
Cdd:pfam00474 81 GKRIlVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 222 MAFMVMKHVGfSFNNLFTEAMAVHPKGEAIMSPGGL--VKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVF 299
Cdd:pfam00474 161 LMIIVFHEVG-GYSSAVEKYMTADPNGVDLYTPDGLhiLRDPLTGLSLWPGLVLGTTGLPHILQRCLAAKDAKCIRCGVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 300 YATGFMGYFYILTFIIGFGAIMLVGANPafkDAAGALIGGNNMAAVHLADAVGGNLFLGFISAVAFATILAVVAGLTLAG 379
Cdd:pfam00474 240 ILTPMFIIVMPGMISRGLFAIALAGANP---RACGTVVGCSNIAYPTLAVKLGPPGLAGIMLAVMLAAIMSTLTSQLLSS 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 380 ASAVSHDLYANVIRKG-ASERDELKVSKITVLVLGVVAILLGILFEKQNIAFMVGLAFSIAASCNFPIILLSMYWSKLTT 458
Cdd:pfam00474 317 SSAFTHDLYKNIRRKAsATEKELVGRSRIIVLVVISLAILLAVQPAQMGIAFLVQLAFAGLGSAFLPVILLAIFWKRVNE 396
|
410
....*....|
gi 697051813 459 RGAMIGGWLG 468
Cdd:pfam00474 397 QGALWGMIIG 406
|
|
| PutP |
COG0591 |
Na+/proline symporter [Amino acid transport and metabolism]; |
32-528 |
1.04e-69 |
|
Na+/proline symporter [Amino acid transport and metabolism];
Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 231.63 E-value: 1.04e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 32 NWQAIVMFLIFVLLTLYITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLGFL 111
Cdd:COG0591 2 STLDLIIIILYLLLLLGIGLYASRRTKSLEDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSALWYALGYA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 112 VGWPIILFLIAERLRNLGRYTFADVASYRLKQGpIRTLSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHVAVVLVGVL 191
Cdd:COG0591 82 LGALLLALFFAPRLRRLGALTIPEFLEKRFGRG-LRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLGILIGALI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 192 MVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGfSFNNLFTeamAVHPKGEAIMSPGGLVKDPISALSLGLGL 271
Cdd:COG0591 161 VLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALG-GFGELFA---ALPAPGLLSLFPGLGFTGWLAFLGLFLAI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 272 MFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPAFKdaagaliggNNMAAVHLADAV 351
Cdd:COG0591 237 GLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARALFPDLPLAD---------PDLALPLLILEL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 352 GGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKGASERDELKVSKITVLVLGVVAILLGILFeKQNIAFM 431
Cdd:COG0591 308 LPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVGLLALLLALLF-PSSILDL 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 432 VGLAFSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLLTAVILMilgptiwvqILGHASAIFPYEYPALFSIAVAFIGI 511
Cdd:COG0591 387 VLLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWK---------LLGGPLGPFGWLYPILPGLLVSLLVF 457
|
490
....*....|....*..
gi 697051813 512 WFFSATDNSPEGNLERE 528
Cdd:COG0591 458 VVVSLLTKPPSEEVLEE 474
|
|
| Na_symport_lg |
TIGR03648 |
probable sodium:solute symporter, VC_2705 subfamily; This family belongs to a larger family of ... |
40-478 |
2.97e-66 |
|
probable sodium:solute symporter, VC_2705 subfamily; This family belongs to a larger family of transporters of the sodium:solute symporter superfamily, TC 2.A.21. Members of this strictly bacterial protein subfamily are found almost invariably immediately downstream from a member of family TIGR03647. Occasionally, the two genes are fused.
Pssm-ID: 274698 Cd Length: 552 Bit Score: 224.44 E-value: 2.97e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 40 LIFVLLT--LYIT--YWAskRVRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLGFLVGWP 115
Cdd:TIGR03648 2 YLFVGATfaLYIGigIWS--RAGSTSEFYVAGRGVPPVANGMATAADWMSAASFISMAGLIAFLGYDGLAYLMGWTGGYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 116 IILFLIAERLRNLGRYTFADVASYRLKQGPIRTLSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHVAVVLVGVLMVMY 195
Cdd:TIGR03648 80 LLALLLAPYLRKFGKYTVPDFIGDRYYSNTARLVAVICAIFISFTYVAGQMRGVGVVFSRFLEVDFETGVFIGMAIVFFY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 196 VLFGGMLATTWVQIIKAVLLLF----GASFMAFMVMKHV--GFSFNNLFTEAMAVHPKGE--------AIMSPGGlVKDP 261
Cdd:TIGR03648 160 AVLGGMKGVTWTQVAQYIVLIVaylvPAIFISLKLTGNPvpQLGYGSALSGVYLLDKLDElevdlgfaEYTEPFG-SKSR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 262 ISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFY-------------ILTFIIG------------ 316
Cdd:TIGR03648 239 INVFALTLALMVGTAGLPHVIVRFYTVPKVRDARWSAGWALFFIALLYttapavaafarynLITTVNGtpyaelpgwvan 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 317 ---FGAIMLVGANP----AFKDAAGALIGGNNMAAVhLADAVGGNL---FLGFISAVAFATILAVVAGLTLAGASAVSHD 386
Cdd:TIGR03648 319 wekTGLLKFEDKNGdgilQYSGDAGNELTIDRDIIV-LATPEIAGLpywVIGLVAAGGLAAALSTAAGLLLVISSAISHD 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 387 LYANVIRKGASERDELKVSKITVLVLGVVAILLGILfEKQNIAFMVGLAFSIAASCNFPIILLSMYWSKLTTRGAMIGGW 466
Cdd:TIGR03648 398 LYYRIINPNASEKQRLLVARIALVVAAVIAGYFGLN-PPGFIAQVVAFAFGLAAASFFPALVLGIFWKRMNREGAIAGML 476
|
490
....*....|..
gi 697051813 467 LGLLTAVILMIL 478
Cdd:TIGR03648 477 TGLGFTFSYIVY 488
|
|
| SLC5sbd_PutP |
cd11475 |
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ... |
36-515 |
5.10e-63 |
|
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271369 Cd Length: 464 Bit Score: 213.52 E-value: 5.10e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 36 IVMFLIFVLLTLYITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLGFLVGWP 115
Cdd:cd11475 1 LITFIVYLLLMLGIGIYSYRKTKTLEDYFLGGRSLGPWVTALSAGASDMSGWLLLGLPGAAYASGLSAIWIAIGLILGAY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 116 IILFLIAERLRNL----GRYTFADVASYRLKQ--GPIRTLSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHVAVVLVG 189
Cdd:cd11475 81 LNWLFVAKRLRRYteknDSITLPDYLENRFRDksKLLRILSALIILIFFTIYAAAQLVAGGKLFESLFGIDYSTGLLIGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 190 VLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGfSFNNLFTEAMAVHPkGEAIMSPGGLVKDPISALSLGL 269
Cdd:cd11475 161 VVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAALG-GLSGLVAALAAIDP-GLLSPFGGDLGAGGLLAIISLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 270 GLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGanpafkdaaGALIGGNNMAAVHLAD 349
Cdd:cd11475 239 AWGLGYFGQPHILVRFMAIRSPKEIKKARRIAMVWMILFLLGAVLVGLLGRALFP---------DGLLGDPETVFPVLAQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 350 AVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKGASERDELKVSKITVLVLGVVAILLGiLFEKQNIA 429
Cdd:cd11475 310 ELFPPWLAGILLAAILAAIMSTADSQLLVCSSALTEDLYKAFLRKEASDKELVWVSRLAVLVIALIALLIA-LNPPSSVF 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 430 FMVGLAFSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLLTAVilmilgptIWVQILGHASAIfpyeYPALFSIAVAFI 509
Cdd:cd11475 389 SLVSFAWAGLGAAFGPLLLLSLYWKRTTRQGALAGMIAGAVTVV--------VWKLLGLGIFGL----YEIVPGFLASLL 456
|
....*.
gi 697051813 510 GIWFFS 515
Cdd:cd11475 457 AIVVVS 462
|
|
| SLC5sbd |
cd10322 |
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
36-515 |
1.66e-62 |
|
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.
Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 212.03 E-value: 1.66e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 36 IVMFLIFVLLTLYITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLGFLVGWP 115
Cdd:cd10322 3 LIIVVVYLALLLGIGLYASKKVKSSEDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYILGAALGAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 116 IILFLIAERLRNLGRYTFADVASYRLKQGPIRTLSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHVAVVLVGVLMVMY 195
Cdd:cd10322 83 LLALFLAPRLRRLGKTTIPETILERYYSKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVIIAAVIVILY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 196 VLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFTEAMAVHPKGEAIMSPGGlvkdPISALSLGLGLMFGT 275
Cdd:cd10322 163 TVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGGGGFSALAAALPALLLALGPGGGLG----WSTILSLILLTGLGV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 276 AGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGAnpafkdaagalIGGNNMAAVHLADAVGGNL 355
Cdd:cd10322 239 LALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPD-----------LENPDLALPTLINSLLPPG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 356 FLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKGASERDELKVSKITVLVLGVVAILLGILFekQNIAFMVGLA 435
Cdd:cd10322 308 LAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKASDKKLLRVSRIAVVVVGVLALLLALLP--PSILLLLSLA 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 436 FSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLLTAVILMILGPTIWVQIlghasaifpyeYPALFSIAVAFIGIWFFS 515
Cdd:cd10322 386 AGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLPLASPLGI-----------DPIIPALLVSLIVFVVVS 454
|
|
| sss |
TIGR00813 |
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
66-464 |
4.80e-48 |
|
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 172.10 E-value: 4.80e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 66 AGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGP 145
Cdd:TIGR00813 1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGKRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 146 IRTLSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHVAVVLVGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFM 225
Cdd:TIGR00813 81 LRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPVF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 226 VMKHVGFsFNNLFTEAMAVHPkgeAIMSPGGLVKDPISALSLGLGLMFGTAGLPH----------ILMRFFTVSDAREAR 295
Cdd:TIGR00813 161 AFSEVGG-LGTFVEKASQAAP---TNPSPDDLYDFFRDPSTSDLPWGAGVFGLPHvalwywtnqvIVQRCLAAKSAKHAK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 296 KSVFYATGFMGYFYILTFIIGFGAIMLVGAnpAFKDAAGALIGGNNMAAVHLADAVGGNLFLGFISAVAFATILAVVAGL 375
Cdd:TIGR00813 237 KGCLISGVLKLLPMFGAVLPGLIARALYTD--IDPALAGAVNQNSDQAYPLLVQELMPPGLAGLFLAAILAAVMSTLSSQ 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 376 TLAGASAVSHDLYANVIRKGASERDEL-KVSKITVLVLGVVAILLgILFEKQNIAFMVGLAFSIAASCNFPIILLSMYWS 454
Cdd:TIGR00813 315 LNSASTVFTMDLYKKIIRPNASGEKKIvMRGRIAVLVAAVIAGFV-AAAQGGQVLQYVQEAFGGLGAPFLPVFLLGIFWK 393
|
410
....*....|
gi 697051813 455 KLTTRGAMIG 464
Cdd:TIGR00813 394 RMNAKGALAG 403
|
|
| SLC5sbd_u1 |
cd11477 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
36-509 |
1.35e-28 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271371 Cd Length: 493 Bit Score: 118.84 E-value: 1.35e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 36 IVMFLIFVLLTLYITYWASKR-VRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLGFLVGW 114
Cdd:cd11477 3 WLVIALYFLLMLGIGLWFSKRaSKSTSDFFLGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAGNWIWWLWAVAG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 115 PIILFLIAERLRNLGRYTFADVASYRLKQGPIRTLS----ACGSLVVVALYLIAQMVGAGKLIELLFGLNYHVAVVLVGV 190
Cdd:cd11477 83 LIGAFVFARRWRRLRVLTDGEFPEERYGGRYGAPLRqfyaVYFALLSNVDILAWVFLAAIKVSAVFGPWDPWLTILILGL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 191 LMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFS---FNNLFTEAMAVHPKGEAIMSPGGLVkdpISALSL 267
Cdd:cd11477 163 ITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLALNAVGGPgglFAQLPEGHLDLFGSGLGASGFYITF---FFILFF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 268 GLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGanpafkdAAGALIGGNNMAAVHL 347
Cdd:cd11477 240 GWYPLSYSGGGWYLAQRYLSAKSEKAAKAAAWLFAALYLVRPWPWMLPALAALVLYP-------DLDDPEADFELAYPMM 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 348 ADAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKGASERDELKVSKITVLVLGVVAILLGilFEKQN 427
Cdd:cd11477 313 IKEYLPAGLLGLVLAGLLAATMSTVSTHLNWGAAYLVNDIYKRFIKPNASEKHLLKVGRLATVLFGLLSIVVA--LASDS 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 428 IAFMVGLAFSIAASCNFPIIlLSMYWSKLTTRGAMIGGWLGLLTAVILMILGPTIWVQILGHASAIFPYEYPALFSIAVA 507
Cdd:cd11477 391 IGGAFWIVLALGAGLGGPLI-LPWLWWRFNAWTEIWAMIASIIVGLVVSVLLKVFGLPEDFLFSFLVPVLLSLVVWLAVT 469
|
..
gi 697051813 508 FI 509
Cdd:cd11477 470 LL 471
|
|
| PRK15419 |
PRK15419 |
sodium/proline symporter PutP; |
36-527 |
5.86e-28 |
|
sodium/proline symporter PutP;
Pssm-ID: 185317 Cd Length: 502 Bit Score: 117.42 E-value: 5.86e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 36 IVMFLIFVLLTLYITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLGFLVGWP 115
Cdd:PRK15419 8 LVTFCVYIFGMILIGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGISESWIAIGLTLGAW 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 116 IILFLIAERLR-----NLGRYTFADVASYRLKQGP--IRTLSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHVAVVLV 188
Cdd:PRK15419 88 INWKLVAGRLRvhteyNNNALTLPDYFTGRFEDKSriLRIISALVILLFFTIYCASGIVAGARLFESTFGMSYETALWAG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 189 GVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFsfnnlFTEAMAVhPKGEAIMSPGGLVKDPISALSLG 268
Cdd:PRK15419 168 AAATILYTFIGGFLAVSWTDTVQASLMIFALILTPVIVIISVGG-----FGDSLEV-IKQKSIENVDMLKGLNFVAIISL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 269 LGLMFGTAGLPHILMRFFtvsdAREARKSVFYATGFMGYFYILTF----IIGFGAIMLVGANPAFkdaAGALIGGNNMAA 344
Cdd:PRK15419 242 MGWGLGYFGQPHILARFM----AADSHHSIVHARRISMTWMILCLagavAVGFFGIAYFNEHPAV---AGAVNQNAERVF 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 345 VHLADAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKGASERDELKVSKITVLVLGVVAILLGILFE 424
Cdd:PRK15419 315 IELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKHASQKELVWVGRVMVLVVALVAIALAANPE 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 425 KQNIAfMVGLAFSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLLTAVilmilgptIWVQilghasaifpYEYPALFSI 504
Cdd:PRK15419 395 NRVLG-LVSYAWAGFGAAFGPVVLFSVMWSRMTRNGALAGMIIGALTVI--------VWKQ----------FGWLGLYEI 455
|
490 500
....*....|....*....|....*..
gi 697051813 505 AVAFI----GIWFFSATDNSPEGNLER 527
Cdd:PRK15419 456 IPGFIfgsiGIVVFSLLGKAPSAAMQK 482
|
|
| SLC5sbd_CHT |
cd11474 |
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
36-496 |
3.25e-27 |
|
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 114.54 E-value: 3.25e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 36 IVMFLIFVLLTLYITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLI-----YSLG- 109
Cdd:cd11474 1 LIGVILYYLLILGIGLWASRRVKSSEDFLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLGGVAqdpfgYALCl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 110 FLVGwpiilFLIAERLRNLGRYTFADVasYRLKQGpiRTLSACGSLVVVALYLI---AQMVGAGKLIELLFGLNYHVAVV 186
Cdd:cd11474 81 ILGG-----LFFAKPMRRMGLLTLGDF--FRQRYG--RRVEVLLSIPAVLSYLGwvaAQLVALGLVLSVILGLPVETGIL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 187 LVGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFsfnnlFTEAMAVHPKGEAIMSPGGLVKDPISALS 266
Cdd:cd11474 152 ISAAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGG-----VDIASAAAAGKLRFFPWLGTKSDWLIWID 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 267 LGLGLMFGtaGLPHILM--RFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPAFKDAAGALIGGNNMAA 344
Cdd:cd11474 227 AWLTLGLG--SIPQQDVfqRVLSAKSEKTAQRLSLLAGVGYLLFAIPPLLIGLAAASIDPSLTQYGLEEDAQLILPLLLQ 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 345 VHLADAVGGnLFLGFISAVafatILAVVAGLTLAGASAVSHDLYANVIRKGASERDELKVSKITVLVLGVVAILlgILFE 424
Cdd:cd11474 305 YLTPLWVQV-LFLGALLSA----VMSTADSALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVVFGAIATL--MALT 377
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 697051813 425 KQNIAFMVGLAFSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLLTAVILMILGPTI----WVQILGHASAIFPY 496
Cdd:cd11474 378 VESIYGLVELASDLVLVGLFVPLLAGLYWKRANTYGALAAIIVGLVLRLLGGELLLGLpadiPPQLQGFPFSTLAM 453
|
|
| SLC5sbd_PanF |
cd10327 |
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ... |
36-483 |
4.56e-22 |
|
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212037 Cd Length: 472 Bit Score: 99.20 E-value: 4.56e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 36 IVMFLIFVLLTLYITYWASKRVRSRN-----DYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYdgliyslgf 110
Cdd:cd10327 2 LLPIIIYLVILLGIGFYARRSKKRRSgdfleEYFIGGRSMGGFVLAMTLVATYTSASSFIGGPGAAYKIGL--------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 111 lvGWP-----------IILFLIAERLRNLGRYTFA----DVASYRLKQGPIRTLSACGSLVVVALYLIAQMVGAGKLIEL 175
Cdd:cd10327 73 --GWVllamiqvptgfLTLGVLGKKFAIIARKINAvtiiDYLRARYNSKALVVLSSLALIVFFIAAMVAQFIGGARLLEA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 176 LFGLNYHVAVVLVGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGfSFNNLFTEAMAVHPKgeAIMSPG 255
Cdd:cd10327 151 VTGLSYVTGLLIFGLTVILYTTIGGFRAVALTDAIQGIVMIIGTVLLLVGVLAAGG-GMEAIMATLAEIDPN--LLTPFG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 256 GLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVgANPAFKDAAGA 335
Cdd:cd10327 228 PGFLSPPYILSFWVLVGFGVIGLPQTAVRCMGYKDSKSMHRAMIIGTVVVGFLMLGMHLAGVLGRAVL-PDLEVPDKVIP 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 336 LIGGNNMAAvHLAdavggnlflGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKGASErDELKVSKITVLVLGVV 415
Cdd:cd10327 307 TLALKVLPP-WLA---------GLFLAGPLAAIMSTVDSQLILASSAIVKDLYLNYKNKEKKT-SEKKVKRISLIITIIL 375
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 416 AILLGILFEK--QNIAFMVGLAFSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLLTAVILMILGPTIW 483
Cdd:cd10327 376 GLLVFLLAINppDLIVWLNLFAFGGLEAAFFWPLVLGLYWKRANATGALASMVVGLVSYILITYLKIKIL 445
|
|
| SLC5sbd_u3 |
cd11479 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
36-478 |
1.31e-18 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271373 Cd Length: 454 Bit Score: 88.43 E-value: 1.31e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 36 IVMFLIFVLLTLYITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDG--LIYSLGflVG 113
Cdd:cd11479 3 YGVIALYFAAMIAIGWWGMRRAKTSEDYLVAGRRLGPGLYLGTMAAVVLGGASTIGGVGLGYQYGISGmwLVVAIG--LG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 114 WPIILFLIAERLRNLGRYTFADVASYRLKQGPiRTLSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHVAVVLVGVLMV 193
Cdd:cd11479 81 ILALSLLLAKRIARLKVYTVSEVLELRYGPSA-RVISALVMLAYTLMVAVTSTIAIGTVFSVLFGLPRTLSILVGGGIVV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 194 MYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFTEAMAVHpkgeaiMSPGGLVKDPISA--LSLGLGL 271
Cdd:cd11479 160 LYSVLGGMWSITLTDIIQFVIKTIGIFLLLLPLALSKAGGLSGLQEKLPASY------FDLTSIGWDTIVTyfLLYFFGI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 272 MFGTaglpHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVganPAFKDAAGALiggnnmaaVHLADAV 351
Cdd:cd11479 234 LIGQ----DIWQRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAVLL---PDLANPQNAF--------ATMAQEV 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 352 GGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKGASERDELKVSKITVLVLGVVAILLGILFekQNIAFM 431
Cdd:cd11479 299 LPVGLRGLVLAAALAAMMSTASGALLASSTVLTNDVLPRLRRKNESERSEVRLSRLFTLLLGVVVIVIAVLV--NDVVAA 376
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 697051813 432 VGLAFSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLLTAVILMIL 478
Cdd:cd11479 377 LTIAYAILVGGLLVPILGGLFWKRATGAGALASMVAGSVVVLAGMAV 423
|
|
| SLC5sbd_DUR3 |
cd11476 |
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ... |
36-474 |
1.34e-18 |
|
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271370 Cd Length: 493 Bit Score: 88.80 E-value: 1.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 36 IVMFLIFVLLTLYITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLI-YSLGFLVgw 114
Cdd:cd11476 8 GALFALLMVFITRLLKRYRGKNQSSEEFMTAGRSVGTGLTAAAIVSSWTWAATLLQSATVAYQYGVSGPFwYASGATL-- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 115 PIILF-LIAERLRNL--GRYTFADVASYRLKQGPIRTLSACgSLVVVALYLIAQMVGAGKLIELLFGLNYHVAVVLVGVL 191
Cdd:cd11476 86 QILLFaPLAIRIKRLapNAHTLLEIVRARYGTAAHLVFLVF-ALFTNVIVLAMLLLGGSAVVNALTGMPIVAASFLIPLG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 192 MVMYVLFGGMLAT---TWVQIIKAVLLLFGASFMAFMVMKHVGFS-FNNLFTEAMAVHPkgeaIMSPGGLVKDP--ISAL 265
Cdd:cd11476 165 VLLYTLFGGLRATfltDYIHTVIILIILLVFAFAVYTSSDIGSPSkVYDLLQEAAPDLP----VEGNQGSYLTFksKAGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 266 SLGLGLMFGTAGL----PHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLvGANPAFKDaagaliGGNN 341
Cdd:cd11476 241 IFGIINIVGNFGTvfldQGYWQRAIAARPSAAVKGYFLGGLAWFAIPFLLATTLGLAALAL-GLNPTFEE------VSAG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 342 MAAVHLADAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKGASERDELKVSKITVLVLGVVAILLGI 421
Cdd:cd11476 314 LVLPYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTYDIYRTYINPNATGKQLLRVSRIAVIGFGLFMGGLAV 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 697051813 422 LFEKQ--NIAFMVGLAFSIAASCNFPIIlLSMYWSKLTTRGAMIGGWLGLLTAVI 474
Cdd:cd11476 394 GLNYIgiSLGWLLLFMGILIGSAVFPVA-LGLYWRRQTGTAAVVSPIAGLVAGLA 447
|
|
| SLC5sbd_u2 |
cd11478 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
33-509 |
2.11e-16 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271372 Cd Length: 496 Bit Score: 81.95 E-value: 2.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 33 WQAIVMFLIFVLLtlyITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSG-------YDGLI 105
Cdd:cd11478 3 YLIVAVYFVFVLG---IGFYLKRKVKTSEDFFLSGRSLPAWITGLAFISANLGALEIVGMSANGAQYGiatvhfyWIGAI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 106 YSLGFLvGWPIILFLIAERLRNLGRYtfadvasYRLKQG-PIRTLSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHVA 184
Cdd:cd11478 80 PAMVFL-GIVMMPFYYGSKVRSVPEY-------LKLRFNkSTRLLNAVSFAVMTILMSGINLYALALVLNVLLGWPLWLS 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 185 VVLVGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGfSFNNLFTEAMAVHPKGEAIMSPGGLVKDPISA 264
Cdd:cd11478 152 IILSAAIVLAYTTLGGLTSAIYNEVLQFFLIVAGLIPLVIIGLIKVG-GWDGLSEKIDANGPPGWNGLSWGPQGSQSTNP 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 265 LSLGLGLMFGtagLPHIL------------MRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPAFKDA 332
Cdd:cd11478 231 MGVNLGLVFG---LGFVLsfgywttnflevQRAMAAKDLSAARRTPLIAAFPKMFIPFLVILPGLIALVLVPELGASGGL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 333 AGaliggnNMAAVHLADAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKGASERDELKVSKITVLVL 412
Cdd:cd11478 308 DY------NQALPYLMAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIYQTYIVKDAPDKHYLKVGRIATVVG 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 413 GVVAILLG-ILFEKQNIAFMVGLAFSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLLTAVILMILGPTIWVQILGHAS 491
Cdd:cd11478 382 VLISIGTAyIASSFNNIMDYLQLLFSFFNAPLFATFLLGMFWKRATPWGGFWGLLAGTASAIVLYGLYELGLIVYHSDMA 461
|
490
....*....|....*...
gi 697051813 492 AIFpyeYPALFSIAVAFI 509
Cdd:cd11478 462 PNF---YGAWWAFVVCFV 476
|
|
| SLC5sbd_NIS-like_u2 |
cd11494 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
32-493 |
7.71e-13 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271385 [Multi-domain] Cd Length: 473 Bit Score: 70.71 E-value: 7.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 32 NWQAIVMFLIFVLLtlyITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLGFL 111
Cdd:cd11494 2 DWIVLVGYLLGILV---YGVYKGRGQKNQEDYFLGGRSMPWWPIGLSIMATQASAITFLSAPGQAYSDGMRFVQYYFGLP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 112 VGWPIILFLIAERLRNLGRYTFADVASYRLKQGpIRTLSAcgslvvvALYLIAQMVGAGKLI-------ELLFGLNYHVA 184
Cdd:cd11494 79 LAMIFLCITFVPVFYKLKVYTAYEYLERRFGLK-TRLLTS-------ILFLISRGLATGVTIyapaiilSTILGWSLWLT 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 185 VVLVGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFTEAMAvHPKGEAI-MSPGGLVKDPIS 263
Cdd:cd11494 151 ILLIGGITIIYTVLGGIKAVIWTDVIQMVIIWAGLFIAFGLLLKLLPVGFVDALLVAGK-SGRLNALdFSFDLSDTYTFW 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 264 ALSLGLGLM----FGTAGLphILMRFFTVSDAREARKSVF---YATGFMGYFYILtfiIGFGAIMLVGANPAFKDAAGAL 336
Cdd:cd11494 230 SGLIGGFFLylsyFGTDQS--QVQRYLTAKSIKEARKSLLlngFLKFPMQFFILL---IGVLVFVFYQFNPFPVSFNPAE 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 337 IGGNNMAAVHLaDAVGGNL---FLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKGASERDELKVSKITVLVLG 413
Cdd:cd11494 305 DETKDTNYIFL-RFVLNYLppgVIGLLIAAIFAAAMSSIDSALNSLATVTVIDIYRRFFKKDASDEHYLKVSRLLTVFWG 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 414 VVAI---LLGILFEkqNIAFMVGLAFSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLLtAVILMILGPTI---WVQIL 487
Cdd:cd11494 384 LLAIvfaLFAGLAG--SLIEAVNKLGSLFYGPILGVFLLAFFTKKANGKGVFAGAILGVI-VVIVLWLFPDVswlWWNVI 460
|
....*.
gi 697051813 488 GHASAI 493
Cdd:cd11494 461 GCVVVI 466
|
|
| SLC5sbd_NIS-like_u3 |
cd11495 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
37-483 |
1.45e-12 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271386 [Multi-domain] Cd Length: 473 Bit Score: 69.88 E-value: 1.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 37 VMFLIFVLLTLYITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLGFLVGWPI 116
Cdd:cd11495 7 LVLVIYLLAMLGIGLYFSKKQKSTDDYFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKAYATDWNYFVGSLSIIIAAPL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 117 ILFLIAERLRNLGRYTfadvASYRLKQ--GPIRTLSACGSLVV-------VALYLIAQMvgagklIELLFGLNYHVAVVL 187
Cdd:cd11495 87 AAYFFVPFFRRLNVTS----AYEYLEKrfGPWARVYGSLLFILfqlgrmgIVLYLPALA------LSAVTGINPYIIIIL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 188 VGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFTEAMAVHPkgeaiMSPGGLVKDpISALSL 267
Cdd:cd11495 157 MGVLCIIYTVLGGIEAVIWTDVIQGVVLLGGALLCLIILLFSIPGGFGEVFDIAIANGK-----FSLGDFSFS-LTESTI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 268 GLGLMFGTA-------GLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPAFKDAAGAliggn 340
Cdd:cd11495 231 WVIFIGGIFnnlqsytSDQDVVQRYLTTKSIKEAKKSLWTNALLALPVALLFFGIGTALYVFYQQHPELLPAGIN----- 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 341 nmaavhladavGGNLFLGFIsavafATILAV-VAGLTLAG----------------ASAVSHDLYaNVIRKGASERDELK 403
Cdd:cd11495 306 -----------GDAVFPYFI-----VTQLPVgVAGLIIAAifaaamstissslnsvATCITTDFY-KRLSPDPSDKQYLK 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 404 VSKITVLVLGVVAILLGILFEKQNIAFMVGLAFSIAASCNFPII---LLSMYWSKLTTRGAMIGGWLGLLTAVILMILGP 480
Cdd:cd11495 369 VARLITLLVGLLGTLVALYLANAGVKSLLDAFNTLTGLFGGGLAglfLLGIFTKRANAKGALVGIIVSIIVIFWISLLYT 448
|
...
gi 697051813 481 TIW 483
Cdd:cd11495 449 PIH 451
|
|
| SLC5sbd_NIS-like |
cd10326 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
36-514 |
4.15e-12 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271361 [Multi-domain] Cd Length: 472 Bit Score: 68.36 E-value: 4.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 36 IVMFLIFVLLTLYITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLGFLVGWP 115
Cdd:cd10326 2 WAVVVVYFLILLAISYYTSRRNADNDDFFLGNRQSPWYLVAFSMIGTSLSGVTFVSVPGEVGGSGFTYLQMVLGFLLGYL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 116 IILFL------------IAERL-RNLGRYTFADVASYRLKQgpiRTLSACGSLVVVALYLIAqmvgagkLIELLFGLNYH 182
Cdd:cd10326 82 IIAFVllplyyrlnltsIYEYLeDRFGVSSRKTGAVFFLLS---RILGAGIRLYLVALVLQQ-------FLFDSLGIPFW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 183 VAVVLVGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFTEAmavhpkGEAIMSPGGLVKDPI 262
Cdd:cd10326 152 LTVLITGLLIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTIIIISNSLGLGFGEAISAA------GESGYSRIFNFDDDN 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 263 SALSL------GLGLMFGTAGLPHILM-RFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPAFKDAAGA 335
Cdd:cd10326 226 SRRTFwkqflgGIFITIAMTGLDQDMMqRNLSCKNLKDAQKNMLTFGVILVPVNLLFLLLGVLLYTYAQKNGIALPAKDS 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 336 LIGGNNMAAVHLADAVGGNLFLGFISAvAFATILAVVAGLTlagaSAVSHDLYANVIRKG--ASERDELKVSKITVLVLG 413
Cdd:cd10326 306 DQLFPYFALNGLPPGVSGLFVAGIIAA-AMSSADSALTALT----TSFCVDILNRFKRKSekKSERKYVHIAFSLTFVLG 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 414 VVAILLGIlfekqNIAFMVGLAFSIAASCNFPiiLLSMY----WSKLTTRGAmIGGWLGLLTAVILMILGPtiWVQILGh 489
Cdd:cd10326 381 ILVFGSAS-----NSGSLIDAIFKVAGYTYGP--LLGLFafglFTKRAVKDK-WVPLVGLLAPVLSYLLVS--NSEGFF- 449
|
490 500
....*....|....*....|....*
gi 697051813 490 aSAIFPYEYPALFSIAVaFIGIWFF 514
Cdd:cd10326 450 -GYKFGFELLIINGLLT-FLGLLLS 472
|
|
| SLC5sbd_SGLT1-like |
cd10329 |
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ... |
36-478 |
4.47e-10 |
|
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271363 Cd Length: 538 Bit Score: 62.21 E-value: 4.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 36 IVMFLIFVLLTLYITYWASKRVRSRN-DYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYdgLIYSLGFLVGW 114
Cdd:cd10329 1 IVIIAVYFVAVIAIGLWSSRKKRSTVsGYFLAGRSMGWPVIGASLFASNIGSSHLVGLAGSGAASGI--AVGNYEWNAAF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 115 PIILF--LIAERLRNLGRYTFADVASYRLKQGpIRTLSACGSLVVVALYLIAQMVGAGKL-IELLFGLNYHVAVVLVGVL 191
Cdd:cd10329 79 VLLLLgwVFLPFYIRSGVSTMPEFLEKRFGGR-SRVYLSVLSLILYVFTKISVDLYAGALvIKQLLGWDLYLSIIVLLVI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 192 MVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFsfnnLFTEAMAVHPKGEAimspGGLVKDPISALSLGLGL 271
Cdd:cd10329 158 TAIYTIAGGLKAVIYTDTLQAVILIIGSAILMFLAFNEVGG----GWSAYMAAIPSGTA----FHLFRPPDDPDLPWPGL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 272 MFGTAGL--------PHILMRFFTVSDAREARKSVFYAtgfmGYFYILTFII----GFGAIMLVGANPAFKDAAGALIGG 339
Cdd:cd10329 230 LLGYPILgiwywctdQVIVQRVLAAKNLKHARRGALFA----GYLKLLPLFLmvlpGMIARALFPDLVACVVPCGNGVGC 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 340 NNMAAVHLADAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYAnVIRKGASERDELKVSKITVLVLGVVAILL 419
Cdd:cd10329 306 SDIAYPTLVTELLPVGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIYK-RLRPEASEKELVRVGRIATLVVVVISILW 384
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 697051813 420 --------GILFEK-QNIAFMvgLAFSIAAscnfpIILLSMYWSKLTTRGAMIGGWLGLLTAVILMIL 478
Cdd:cd10329 385 apiiqaqgGSLFNYiQSVLSY--LAPPIAA-----VFLLGIFWKRTNEQGAFWGLIAGLVLGLVRLIL 445
|
|
| PRK10484 |
PRK10484 |
putative transporter; Provisional |
33-509 |
1.69e-08 |
|
putative transporter; Provisional
Pssm-ID: 236699 [Multi-domain] Cd Length: 523 Bit Score: 57.20 E-value: 1.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 33 WQAIVMFLIFVLLTLYITYWASKR--VRSRNDYYTAGGNITGFqnglAIAGDFM----SAASFLGISALVYTSGYDGLIY 106
Cdd:PRK10484 1 MLTILSFLGFTLLVAVISWWKTRKtdTSSSDGYFLAGRSLTGP----VIAGSLLltnlSTEQLVGLNGQAYASGMSVMAW 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 107 SLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRTLSAC---GSLVV---VALYLIAQMVGAGKLIELLFGLN 180
Cdd:PRK10484 77 EVTAAIALIILALIFLPRYLKSGITTIPDFLEERYDKTTRRIVSILfliGYVVSflpIVLYSGALALNSLFHVSELLGIS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 181 YHVAVVLVGVLM----VMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGF-SFNNLFTEAMAVHP-KGEAIMSP 254
Cdd:PRK10484 157 YGAAIWLLVWLIgiigAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLIALGDgSFMQGLEQLTTVHPeKLNSIGGA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 255 GGLVkdPISALSLGLGL--MFGTAGLPHILMRFFTVSDAREARKSVFYAtgfmGYFYILTFII----GFGAIMLVGANPA 328
Cdd:PRK10484 237 TDPV--PFPTLFTGLILvnLFYWCTNQSIVQRALGAKNLAEGQKGALLA----AFFKLLGPLIlvlpGIIAFHLYGDGLP 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 329 FKDaagaliggnnMAAVHLADAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKGASERDELKVSKIT 408
Cdd:PRK10484 311 NAD----------MAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYKPIINPNASEKQLVKVGKKF 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 409 VLVLGVVAILLGILfekqnIAFMVGLAFSIAASCN-------FPIILLSMYWSKLTTRGAMIggwlGLLTAVILMILGpt 481
Cdd:PRK10484 381 GFVLAIISMIVAPL-----IANAPQGLYSYLQQLNgiynvpiLAIIIVGFFTKRVPALAAKV----ALGFGIILYIII-- 449
|
490 500
....*....|....*....|....*...
gi 697051813 482 iwvQILGHASAIFPYEYPALFSIAVAFI 509
Cdd:PRK10484 450 ---NFVLKFDIHFLYVLAILFVINVVVM 474
|
|
| SLC5sbd_SGLT4 |
cd11488 |
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ... |
36-478 |
3.52e-08 |
|
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.
Pssm-ID: 271380 Cd Length: 605 Bit Score: 56.10 E-value: 3.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 36 IVMFLIFVLLTLYITYWASKRVR--SRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGY--DGLIYSLGFL 111
Cdd:cd11488 2 IAVVVVYFVFVLAVGIWSSIRASrgTVGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGTGAAGGLavGGFEWNAAWV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 112 V---GWPIILFLIAErlrnlGRYTFADVASYRLKQGPIRTLSACGSLVVVALYLIAQMVGAGKL-IELLFGLNYHVAVVL 187
Cdd:cd11488 82 LialGWIFVPVYIAA-----GVVTMPEYLKKRFGGQRIRIYMSVLSLILYIFTKISTDIFSGALfIQVSLGWNLYLSTVI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 188 VGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGF----------SFNNLFTEAMAVH-PKGEAIMspgg 256
Cdd:cd11488 157 LLAVTALYTIAGGLTAVIYTDALQTVIMVIGAFVLMFIAFDKVGWypgleqqyekAIPALTVPNTTCHlPRSDAFH---- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 257 LVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDARE-ARKSVFYATG---FMGYFYILT--FIIGFGAImlvgANPAFK 330
Cdd:cd11488 233 IFRDPVTGDIPWPGLIFGLTVLATWVWCTDQVIVQRSlSAKNLSHAKGgsvLGGYLKILPmfFVVMPGMI----SRALFP 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 331 DAA------------GALIGGNNMAAVHLADAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANvIRKGASE 398
Cdd:cd11488 309 DEVgcvdpdecqkicGAKVGCSNIAYPKLVVELMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQR-IRRRASE 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 399 RDELKVSKITVLVLGVVAILLGILFEKQNIAFMVGLAFSIAASCNFPI---ILLSMYWSKLTTRGAMIGGWLGLLTAVIL 475
Cdd:cd11488 388 QELMVVGRVFILLLVVISILWIPIIQTANSGQLFDYIQAVTSYLSPPItavFILAIFWKRVNEPGAFWGLMVGLVVGLVR 467
|
...
gi 697051813 476 MIL 478
Cdd:cd11488 468 MIM 470
|
|
| SLC5sbd_NIS-like_u1 |
cd11493 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
36-478 |
6.15e-08 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271384 [Multi-domain] Cd Length: 479 Bit Score: 55.30 E-value: 6.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 36 IVMFLIFVLLTLYITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLGFLVGWP 115
Cdd:cd11493 2 LAVIVLYLLGLPLLGLWLSGRQKSTADYFLGGRSMPWWAVCLSVVATETSTLTFLSIPGLAYGGDLTFLQLALGYILGRI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 116 IILFLIAERLRNLGRYTFADVASYRLKQGPIRTLSA---CGSLVV--VALYLIAQMVGAGkLIELLFGLNYHVAVVLVGV 190
Cdd:cd11493 82 IVAFVLLPRYFRGEVVSAYELLGQRFGGGMQKTASVtflVTRLLAdgVRLFAAAIPVSMI-LGADGVALSYIASILIISV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 191 LMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFnnLFTEAMAVHPKGEAIMSPGGLVKDPISALSLGLG 270
Cdd:cd11493 161 VTLLYTYFGGIRAVVWTDVIQLVVYIGGAVAALAYLLGALPADW--LQIAAAAGKFHLFDLSDLILGLTSPYTFWAAIIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 271 LMF---GTAGLPHILM-RFFTVSDAREARKSVFyATGFMGYFYILTFI-IGFGAIMLVGANPAfkdAAGALIGGNNMAAV 345
Cdd:cd11493 239 GALlsmASHGTDQLMVqRLLACRNLRDAQKALI-GSGVVVFPQFALFLlIGLLLYVYYGGASL---AALGLGSPDEVFPY 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 346 HLADAVGGNLfLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKGASERDELKVSKITVLVLGVVAILLGILFEK 425
Cdd:cd11493 315 FIVHELPAGL-RGLLIAGILAAAMSTLSSALNSLASSTVQDLYQPWKRRRLSDEKLLRASRLLTLVWAVVLVGIALLFQY 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 697051813 426 QNIAfMVGLAFSIAA---SCNFPIILLSMYWSKLTTRGAMIGGWLGLLTAVILMIL 478
Cdd:cd11493 394 TDQP-VVELGLSIASftyGGLLGVFLLGLLTRRASQRDAIAAFIVGFLVMLLLIFG 448
|
|
| SLC5sbd_vSGLT |
cd10325 |
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ... |
37-482 |
1.20e-05 |
|
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271360 Cd Length: 523 Bit Score: 48.07 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 37 VMFLIFVLLTLYITYWASK----RVRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISAlvytSGYD-GL-IYSLGF 110
Cdd:cd10325 1 VIFIVYVILIIGLGLWVSRekkgGEKDATDYFLAGKSLPWWAIGASLIAANISAEQFIGMSG----SGFAiGLaIASYEW 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 111 LVGWPIIL---FLIAERLRNlGRYTFADVASYRLkQGPIRTLSACGSLVV-VALYLIAQMVGAGKLIELLFGLNYHVAVV 186
Cdd:cd10325 77 MAAITLIIvakFFLPIFLKN-GIYTMPQFLEERY-DGRVRTIMAVFWLLLyVFVNLTSVLYLGALAIETITGIPLTYSII 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 187 LVGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNL--FTEAMAVHP-KGEAIMSPGGLVKD--- 260
Cdd:cd10325 155 GLALFAAAYSIYGGLKAVAWTDVIQVVFLVLGGLVTTYIALSLLGGGEGVFagFTLLAAEAPeHFHMILDKSNPEDAykd 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 261 --PISALSLGLGLM-FGTAGL-PHILMRFFTVSDAREARKSVFYAtGFMGYFYILTFIIGfGAIMLVGANPAFKDAAGAL 336
Cdd:cd10325 235 lpGIAVLLGGLWVAnLSYWGFnQYIIQRALAAKSLSEAQKGIVFA-AFLKLLIPFIVVIP-GIAAYVLASNLLLPAATGI 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 337 IGGNNMAAVHLADAVGGnlFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKGASERDELKVSKITVlvlgVVA 416
Cdd:cd10325 313 EKPDQAYPWLLRNLPTG--LKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKKYIPKKASEKQLVNVGRLAA----VIA 386
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 697051813 417 ILLGILFEKQNIAFMVGLAF-----SIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLLTAVILMILGPTI 482
Cdd:cd10325 387 LIIAALIAPPLLGLDQAFQYiqeytGFISPGILAIFLLGLFWKRATSAGALVAAILSIVLSALFKFLLPEL 457
|
|
| SLC5sbd_YidK |
cd10328 |
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ... |
39-512 |
3.72e-05 |
|
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271362 Cd Length: 472 Bit Score: 46.38 E-value: 3.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 39 FLIFVLLTLYITYWASKRVR--SRNDYYTAGGNITGFqnglAIAGDFM----SAASFLGISALVYTSGYDGLIYSLGFLV 112
Cdd:cd10328 1 FLLFTALVALISWYKTRGDDlsSSDGYFLAGRSLTGV----VIAGSLLltnlSTEQLVGLNGQAYALGMSVMAWEVTAAI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 113 GWPIILFLIAERLRNLGRYTFADVASYRLKQGpIRTLsacgslvVVALYLIAQMV---------GAGKLIEL-----LFG 178
Cdd:cd10328 77 ALIILALVFLPRYLKGGITTIPEFLEERYDET-TRRI-------VSILFLLGYVVillpivlysGALALNSLfdvseLLG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 179 LNYHVAVVLVGVLM----VMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGF-SFNNLFTEAMAVHP-KGEAIM 252
Cdd:cd10328 149 ISYFQALWLLVWLIgiigAIYAIFGGLKAVAVSDTINGVGLLIGGLLIPILGLIALGDgSFLAGLDTLLTAHPeKLNAIG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 253 SPGGLVkdPISALSLGLGL--MFGTAGLPHILMRFFTVSDAREARKSVFYAtgfmGYFYILTFII----GFGAIMLVGAN 326
Cdd:cd10328 229 GADSPV--PFSTLFTGMLLvnLFYWCTNQAIIQRALAAKNLKEGQKGVLLA----GFFKLLVPLIlvlpGIIAFHLYGDG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 327 PAFKDAA-GALIGgnnmaavhladAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIRKGASERDELKVS 405
Cdd:cd10328 303 LENADMAyPTLVA-----------DVLPKWLSGFFAAVLFGAILSSFNSALNSAATLFSLDIYKPIINKNATDKQLVKVG 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 406 KITVLVLGVVAILLGILFEKQN---IAFMVGLA--FSIAAscnFPIILLSMYWSKLTTRGAMIggwlGLLTAVILMILGp 480
Cdd:cd10328 372 KIFGIVLALISMIIAPFIAYAPeglFNYLQQFNgfFSIPI---LAIVLVGFFTKRVPALAAKI----ALIFGVILYALL- 443
|
490 500 510
....*....|....*....|....*....|..
gi 697051813 481 tiwvQILGHASAIFPYEYPALFSIAVAFIGIW 512
Cdd:cd10328 444 ----QFVFLVPIHFLHVLAILFVICVAIMLII 471
|
|
| SLC5sbd_SGLT1 |
cd11486 |
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ... |
36-477 |
8.08e-05 |
|
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.
Pssm-ID: 271379 Cd Length: 636 Bit Score: 45.31 E-value: 8.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 36 IVMFLIFVLLTLYITYWASKRVR--SRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSG-------YDGLIY 106
Cdd:cd11486 3 ISVIVIYFVVVLAVGVWAMVSTNrgTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGiaiggfeWNALVV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 107 SLgfLVGWPIILFLIAERLRNLGRYTFADVASYRLKQgpirTLSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHVAVV 186
Cdd:cd11486 83 VV--VLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQV----YLSVLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 187 LVGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGfSFNNLFTEAMAVHPK---------GEAIMSPGG- 256
Cdd:cd11486 157 ILLAITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVG-GYDAFMEKYMTAIPSvigtgnstsQEKCYTPRAd 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 257 ---LVKDPISALSLGLGLMFGTAglphILMRFFTVSDAREAR-----KSVFYATG---FMGYFYIL-TFIIGFGAIM--- 321
Cdd:cd11486 236 sfhIFRDPITGDLPWPGLLFGLS----ILTLWYWCTDQVIVQrclsaKNMSHVKAgciLCGYLKLLpMFIMVMPGMIsri 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 322 -----LVGANPAF-KDAAGALIGGNNMAAVHLADAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANViRKG 395
Cdd:cd11486 312 lytdeIACVVPDEcKAVCGTEVGCTNIAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKV-RKK 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 396 ASERDELKVSKITVLVLGVVAILLGILFEKQNIAFMVGLAFSIAASCNFPI---ILLSMYWSKLTTRGAMIGGWLGLLTA 472
Cdd:cd11486 391 ASEKELMIAGRLFMLVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIaavFLLAIFCKRVNEPGAFWGLCVGLLVG 470
|
....*
gi 697051813 473 VILMI 477
Cdd:cd11486 471 LARMI 475
|
|
| SLC5sbd_SGLT5 |
cd11489 |
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ... |
36-478 |
1.08e-03 |
|
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212058 Cd Length: 604 Bit Score: 41.85 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 36 IVMFLIFVLLTLYITYWASKRVrSRND---YYTAGGNITGFQNGLAIAGDFMSAASFLGISAlvytSGYDGLIYSLGF-- 110
Cdd:cd11489 5 IIVIGVYFALNVAVGIWSSCRV-SRNTvsgYFLAGRDMAWWPIGASLFASSEGSGLFIGLAG----TGAAGGIAVAGFew 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 111 -------LVGWPIILFLIAERLRNLGRYTFADVASYRLKQgpirTLSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHV 183
Cdd:cd11489 80 natyallALAWVFVPVYISSGIVTMPEYLQRRFGGERIRM----YLSVLSLLLSVFTKISTDLYSGALFVQVCLGWNLYL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 184 AVVLVGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFTEAMAVH-----------PKGEAIM 252
Cdd:cd11489 156 STVLMLVVTALYTIAGGLAAVIYTDALQTLIMVIGAVILTIKAFNQIGGYSNLEEAYLQAVPskiipnttchlPRADAMH 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 253 spggLVKDPISALSLGLGLMFGTAGLPH--------ILMRFFTVSDAREARKSVFYATgfmgYFYILT--FIIGFGAIML 322
Cdd:cd11489 236 ----LFRDPVTGDLPWTGMTFGLTIMATwywctdqvIVQRSLSARSLSHAKGGSILAS----YLKMLPmgLIIMPGMISR 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 323 VganpAFKD------------AAGALIGGNNMAAVHLADAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYAN 390
Cdd:cd11489 308 A----LFPDdvacvdpeeclrVCGAEVGCSNIAYPKLVMELMPSGLRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWRR 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 391 vIRKGASERDELKVSKITVLVLGVVAILLGILFEKQNIAFMVGLAFSIAASCNFP---IILLSMYWSKLTTRGAMIGGWL 467
Cdd:cd11489 384 -LRPGASERELLLVGRLVTVILVGVSVVWIPILQSSNSGQLYIYIQSVTSYLAPPvtaVFVLAVFWRRANEQGAFWGLMA 462
|
490
....*....|.
gi 697051813 468 GLLTAVILMIL 478
Cdd:cd11489 463 GLVVGLTRMVL 473
|
|
| SLC5sbd_SGLT6 |
cd11490 |
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ... |
36-478 |
2.27e-03 |
|
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271381 Cd Length: 602 Bit Score: 40.66 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 36 IVMFLIFVLLTLYITYWASKRvRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLG-----F 110
Cdd:cd11490 5 LVLYFLFVLAVGLWSMWKTKR-STVKGYFLAGKDMTWWPVGASLFASNVGSGHFIGLAGSGAAAGIGVVAYEWNglfmvL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 111 LVGWPIILFLIAERLRNLGRYtfadvasYRLKQGPIRTlsacgSLVVVALYLI--------AQMVGAGKLIELLFGLNYH 182
Cdd:cd11490 84 VLAWLFLPIYIASRVTTMPEY-------LKKRFGGKRI-----QIFLAVLYLFiyiftkisVDMYAGAVFIQQALQWDLY 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 183 VAVVLVGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGfSFNNLFTEAMAVHPKGEAIMSPGGL----- 257
Cdd:cd11490 152 LAVVGLLGITALYTVAGGLAAVIYTDALQTIIMVIGALILMGYSFAEVG-GFEALLEKYFQAIPSIRSPNSTCGIpreda 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 258 ---VKDPISALSLGLGLMFGTAglphILMRFFTVSDA-----REARKSVFYATG---FMGYFYILTFIIGFGAIML---- 322
Cdd:cd11490 231 fhiFRDPVTSDLPWPGVLLGMS----IPSLWYWCTDQvivqrSLAAKNLSHAKGgslLAAYLKVLPLFMMVIPGMIsril 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 323 ----VG-ANPAF-KDAAGALIGGNNMAAVHLADAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANvIRKGA 396
Cdd:cd11490 307 fpdqVAcADPEVcKEICGNPSGCSDIAYPKLVMELLPTGLRGLMMAVMLAALMSSLTSIFNSASTIFTMDLWRH-IRPRA 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 397 SERDELKVSKITVLVLGVVAILLGILFEKQNIAFMVGLAFSIAASCNFP---IILLSMYWSKLTTRGAMIGGWLGLLTAV 473
Cdd:cd11490 386 SEWELMIVGRVFVLVLVVVSILWIPLVQASQGGQLFIYIQSISSYLQPPvavVFIAGCFWKRTNEKGAFWGLMVGLAVGL 465
|
....*
gi 697051813 474 ILMIL 478
Cdd:cd11490 466 TRMVL 470
|
|
| SLC5sbd_NIS |
cd11503 |
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ... |
38-218 |
2.68e-03 |
|
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271393 Cd Length: 535 Bit Score: 40.60 E-value: 2.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 38 MFLIFVLLTLYITYWASKRV---RSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLGFLVGW 114
Cdd:cd11503 5 VFAAMLLVSTGIGLFVGLARggqRSADDFFTGGRGLSAVPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 115 PIILFLIAERLRNLGRYTFADVASYRLKqgpiRTLSACGSLvvvaLYLIAQMVGAGKLI-------ELLFGLNYHVAVVL 187
Cdd:cd11503 85 LMTAVLFMPVFYRLGITSTYQYLEMRFS----RAVRLCGTL----QFIVATMLYTGIVIyapalilNQVTGLDIWASLFS 156
|
170 180 190
....*....|....*....|....*....|.
gi 697051813 188 VGVLMVMYVLFGGMLATTWVQIIKAVLLLFG 218
Cdd:cd11503 157 TGIICTFYTTVGGMKAVIWTDVFQVVVMLSG 187
|
|
| SLC5sbd_SMIT |
cd11491 |
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ... |
36-478 |
3.89e-03 |
|
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271382 Cd Length: 609 Bit Score: 39.85 E-value: 3.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 36 IVMFLIFVLLTLYITYWASKRVrSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLGFLVGWP 115
Cdd:cd11491 5 VALYFILVMCIGIYAMWKSNRS-TVSGYFLAGRSMTWLPVGASLFASNIGSEHFIGLAGSGAAAGFAVGAFEFNALILLQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 116 IILFLIAERLRNLGRYTFADVASYRLKQGPIRTLSACGSLVVVALYLIAQMVGAGKL-IELLFGLNYHVAVVLVGVLMVM 194
Cdd:cd11491 84 LLGWVFIPVYIRSGVYTLPEYLSKRFGGHRIQVYLAALSLILYIFTKISVNLYSGALfIQEALGWNLYVSIILLLGLTAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 195 YVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVG--------------------FSFNNLFTEAMAVHPKGEAIMsp 254
Cdd:cd11491 164 LTVTGGLAAVIYTDTLQAFLMIIGALTLMIISMMEIGgfegvksrymlaspnvtsilLTYNLSNTNSCCVHPKKDAFK-- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 255 ggLVKDPISALSLGLGLMFGTAGLP--------HILMRFFTVSDAREARKSVFYAtGFMGYFYILTFIIG-------FGA 319
Cdd:cd11491 242 --LLRDPTDEDVPWPGFILGQTPASiwywcadqVIVQRVLAAKSLSHAQGATLMA-GFIKLLPLFIIVIPgmisrilFPD 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 320 IMLVGANPAFKDAAGALIGGNNMAAVHLADAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYAnVIRKGASER 399
Cdd:cd11491 319 DIACINPEHCMQVCGSRAGCSNIAYPRLVMKIMPSGLRGLMMAVMIAALMSDLTSIFNSASTLFTLDVYK-LIRKKASSR 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 400 DELKVSKITVLVLGVVAIL-LGILFEKQNIAFMVGLAfSIAASCNFPI---ILLSMYWSKLTTRGAMIGGWLGLLTAVIL 475
Cdd:cd11491 398 ELMIVGRIFVAVMVVISIAwIPVIQEMQGGQLYLYIQ-EVAAYLTPPVaslYLLAIFWKRTTEQGAFYGGMAGFVLGAVR 476
|
...
gi 697051813 476 MIL 478
Cdd:cd11491 477 LIL 479
|
|
| SLC5sbd_NIS-SMVT |
cd11492 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
37-485 |
4.23e-03 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271383 [Multi-domain] Cd Length: 522 Bit Score: 39.78 E-value: 4.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 37 VMFLIFVLLTLYIT----YWA--SKRVRSRNDYYTAGGNITGFQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSLGF 110
Cdd:cd11492 1 VDYVVFVAMLLISAaigiYFGffGGKQKTTEEYLLGGRNMSVFPVALSLIASFISGITLLGTPAEIYYYGTQYWLIVIAY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 111 LVGWPIILFLIAERLRNLGrytfadVAS---Y---RLKQgPIRTLSACGSLVVVALYL-IAQMVGAgklieLLF----GL 179
Cdd:cd11492 81 VLVGPITAYIFLPVFYNLQ------LTSvyeYlelRFNR-RVRLLASFLFILQMLLYLpIVIYAPA-----LALsqvtGI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 180 NYHVAVVLVGVLMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGfSFNNLFTEAMAVHPKGEAIMSPGGLVK 259
Cdd:cd11492 149 NLHIIILVVGIVCIFYTTLGGLKAVVWTDVFQVVVMFGGVLAVIILGTIDVG-GFSEVWEIAEEGGRLEFFNFDPDPTVR 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 260 DPISALSLGLGLMF--GTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFgaIM-------------LVG 324
Cdd:cd11492 228 HTFWSLVIGGTFTWlsLYGVNQTQVQRYLSLPSLKSAKKALWLNIVGLILILSLCCFTGL--VIyakyhdcdpltagLIK 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 325 AN----PAF-KDAAGALIGgnnMAAVhladavggnlflgFISAVAFATILAVVAGLTlAGASAVSHDLYANVIRKGASER 399
Cdd:cd11492 306 KPdqllPYFvMDVLGHLPG---LPGL-------------FVAGIFSAALSTLSSGLN-SLAAVILEDFIKPFFKKKLSER 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697051813 400 DELKVSKITVLVLGVVAILLGILFEKQNIAFMVGLA-FSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLLTAVILMIL 478
Cdd:cd11492 369 QATNIMKLLVVVFGLLCIGLAFLVEKLGGVLQLSLSiFGITGGPLLGIFTLGMFFPWANSKGALVGLLVGLIFMLWIGIG 448
|
....*..
gi 697051813 479 GPTIWVQ 485
Cdd:cd11492 449 GQIAIAP 455
|
|
| |
