|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
1-420 |
0e+00 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 655.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 1 MSFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTfyaehrGAKRAVRAL 80
Cdd:COG0513 2 MSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDP------SRPRAPQAL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 81 ILTPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEAD 160
Cdd:COG0513 76 ILAPTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDEAD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 161 RMLDMGFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALIEVARRNTTAESVAQKIHPVDRDRKRELLTHL 240
Cdd:COG0513 156 RMLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRDKLELLRRL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 241 IREHNWFQVLVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARGIDIDQLPHVVN 320
Cdd:COG0513 236 LRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVIN 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 321 FDLPNVPEDYVHRIGRTGRAGATGEAVSLVCVDEKQLLRDIERLIKREIPQEVIAGFEPDPNAKPEPIQQRRGQQQPRGG 400
Cdd:COG0513 316 YDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLIGQKIEEEELPGFEPVEEKRLERLKPKIKEKLKGKK 395
|
410 420
....*....|....*....|
gi 736058015 401 GGGGNRQPRAGGSGQPAAKR 420
Cdd:COG0513 396 AGRGGRPGPKGERKARRGKR 415
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
1-439 |
0e+00 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 638.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 1 MSFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTFYAEHRGaKRAVRAL 80
Cdd:PRK10590 1 MSFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKG-RRPVRAL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 81 ILTPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEAD 160
Cdd:PRK10590 80 ILTPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 161 RMLDMGFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALIEVARRNTTAESVAQKIHPVDRDRKRELLTHL 240
Cdd:PRK10590 160 RMLDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDKKRKRELLSQM 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 241 IREHNWFQVLVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARGIDIDQLPHVVN 320
Cdd:PRK10590 240 IGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 321 FDLPNVPEDYVHRIGRTGRAGATGEAVSLVCVDEKQLLRDIERLIKREIPQEVIAGFEPDPNAKPEPIqqrrgQQQPRGG 400
Cdd:PRK10590 320 YELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKLLRDIEKLLKKEIPRIAIPGYEPDPSIKAEPI-----QNGRQQR 394
|
410 420 430
....*....|....*....|....*....|....*....
gi 736058015 401 GGGGNRQPRAGGSGQPAAKRDGHAQPKAAQQKAAKPRTQ 439
Cdd:PRK10590 395 GGGGRGQGGGRGQQQGQPRRGEGGAKSASAKPAEKPSRR 433
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
1-387 |
3.29e-126 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 374.91 E-value: 3.29e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 1 MSFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHtfyaehrgAKR-AVRA 79
Cdd:PRK11776 4 TAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLD--------VKRfRVQA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 80 LILTPTRELAAQVEESVRAYSKYL-KLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDE 158
Cdd:PRK11776 76 LVLCPTRELADQVAKEIRRLARFIpNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 159 ADRMLDMGFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALIEVARRnTTAESVAQKIHPVDRDRKRELLT 238
Cdd:PRK11776 156 ADRMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVEST-HDLPAIEQRFYEVSPDERLPALQ 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 239 HLIREHNWFQVLVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARGIDIDQLPHV 318
Cdd:PRK11776 235 RLLLHHQPESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAV 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 736058015 319 VNFDLPNVPEDYVHRIGRTGRAGATGEAVSLVCVDEKQLLRDIERLIKREIPQEVIAGFEPDPNAKPEP 387
Cdd:PRK11776 315 INYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQRANAIEDYLGRKLNWEPLPSLSPLSGVPLLP 383
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
1-386 |
2.34e-121 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 361.57 E-value: 2.34e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 1 MSFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTFYAEHRGAKRAvraL 80
Cdd:PRK11192 1 TTFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFPRRKSGPPRI---L 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 81 ILTPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEAD 160
Cdd:PRK11192 78 ILTPTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCRAVETLILDEAD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 161 RMLDMGFIHDIKRVLAKLPPQRQNLLFSATF-SDEIKALADSLLDSPALIEVARRNTTAESVAQKIHPVD-RDRKRELLT 238
Cdd:PRK11192 158 RMLDMGFAQDIETIAAETRWRKQTLLFSATLeGDAVQDFAERLLNDPVEVEAEPSRRERKKIHQWYYRADdLEHKTALLC 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 239 HLIREHNWFQVLVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARGIDIDQLPHV 318
Cdd:PRK11192 238 HLLKQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVSHV 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 736058015 319 VNFDLPNVPEDYVHRIGRTGRAGATGEAVSLVCVDEKQLLRDIERLIKREIPQEVIAGFEPDPNAKPE 386
Cdd:PRK11192 318 INFDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDHLLLGKIERYIEEPLKARVIDELRPKTKAPSE 385
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
3-387 |
6.34e-109 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 331.49 E-value: 6.34e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 3 FESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPIL-QRLHTFYAEHRgAKRAVRALI 81
Cdd:PRK01297 89 FHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIInQLLQTPPPKER-YMGEPRALI 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 82 LTPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALK-RGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEAD 160
Cdd:PRK01297 168 IAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEAD 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 161 RMLDMGFIHDIKRVLAKLPP--QRQNLLFSATFSDEIKALADSLLDSPALIEVARRNTTAESVAQKIHPVDRDRKRELLT 238
Cdd:PRK01297 248 RMLDMGFIPQVRQIIRQTPRkeERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAVAGSDKYKLLY 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 239 HLIREHNWFQVLVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARGIDIDQLPHV 318
Cdd:PRK01297 328 NLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHV 407
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 736058015 319 VNFDLPNVPEDYVHRIGRTGRAGATGEAVSLVCVDEKQLLRDIERLIKREIPQEViagfEPDPNAKPEP 387
Cdd:PRK01297 408 INFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQLPEIEELLGRKISCEM----PPAELLKPVP 472
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
2-373 |
6.26e-104 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 320.57 E-value: 6.26e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 2 SFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQrlhtfyaeHRGAKRAVR--- 78
Cdd:PTZ00110 131 SFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIV--------HINAQPLLRygd 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 79 ---ALILTPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILV 155
Cdd:PTZ00110 203 gpiVLVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVTNLRRVTYLV 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 156 LDEADRMLDMGFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLL-DSPALIEVARRN-TTAESVAQKIHPVDRDRK 233
Cdd:PTZ00110 283 LDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCkEEPVHVNVGSLDlTACHNIKQEVFVVEEHEK 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 234 R----ELLTHLIREHNwfQVLVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARG 309
Cdd:PTZ00110 363 RgklkMLLQRIMRDGD--KILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRG 440
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 736058015 310 IDIDQLPHVVNFDLPNVPEDYVHRIGRTGRAGATGEAVSLVCVDEKQLLRDIERLIkREIPQEV 373
Cdd:PTZ00110 441 LDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTPDKYRLARDLVKVL-REAKQPV 503
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
1-371 |
1.05e-102 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 320.26 E-value: 1.05e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 1 MSFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILqrlHTFYAEhrgaKRAVRAL 80
Cdd:PRK11634 6 TTFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLL---HNLDPE----LKAPQIL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 81 ILTPTRELAAQVEESVRAYSKYLKLRSTV-MFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEA 159
Cdd:PRK11634 79 VLAPTRELAVQVAEAMTDFSKHMRGVNVVaLYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 160 DRMLDMGFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALIEVARRNTTAESVAQKIHPVDRDRKRELLTH 239
Cdd:PRK11634 159 DEMLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVWGMRKNEALVR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 240 LIREHNWFQVLVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARGIDIDQLPHVV 319
Cdd:PRK11634 239 FLEAEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVV 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 736058015 320 NFDLPNVPEDYVHRIGRTGRAGATGEAVSLVCVDEKQLLRDIERLIKREIPQ 371
Cdd:PRK11634 319 NYDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNIERTMKLTIPE 370
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
12-210 |
2.05e-102 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 304.36 E-value: 2.05e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 12 LVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHtfyAEHRGAKRAVRALILTPTRELAAQ 91
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLL---PEPKKKGRGPQALVLAPTRELAMQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 92 VEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRMLDMGFIHDI 171
Cdd:cd00268 78 IAEVARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEEDV 157
|
170 180 190
....*....|....*....|....*....|....*....
gi 736058015 172 KRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALIE 210
Cdd:cd00268 158 EKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRIE 196
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
3-370 |
3.41e-95 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 294.19 E-value: 3.41e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 3 FESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTFYAEHRGAKRAVRALIL 82
Cdd:PRK04837 10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSHPAPEDRKVNQPRALIM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 83 TPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRM 162
Cdd:PRK04837 90 APTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRM 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 163 LDMGFIHDIKRVLAKLPP--QRQNLLFSATFSDEIKALADSLLDSPALIEVARRNTTAESVAQKI-HPVDRDRKRELLTh 239
Cdd:PRK04837 170 FDLGFIKDIRWLFRRMPPanQRLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEELfYPSNEEKMRLLQT- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 240 LIREHNWFQVLVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARGIDIDQLPHVV 319
Cdd:PRK04837 249 LIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTHVF 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 736058015 320 NFDLPNVPEDYVHRIGRTGRAGATGEAVSLVCVDEKQLLRDIERLIKREIP 370
Cdd:PRK04837 329 NYDLPDDCEDYVHRIGRTGRAGASGHSISLACEEYALNLPAIETYIGHSIP 379
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
1-480 |
8.59e-89 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 282.22 E-value: 8.59e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 1 MSFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTFYAEHRGAKRAVRAL 80
Cdd:PRK04537 9 LTFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALADRKPEDPRAL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 81 ILTPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQ-KTIDLSDLDILVLDEA 159
Cdd:PRK04537 89 ILAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQhKVVSLHACEICVLDEA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 160 DRMLDMGFIHDIKRVLAKLPPQ--RQNLLFSATFSDEIKALADSLLDSPALIEVARRNTTAESVAQKIHPVDRDRKRELL 237
Cdd:PRK04537 169 DRMFDLGFIKDIRFLLRRMPERgtRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFPADEEKQTLL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 238 THLIREHNWFQVLVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARGIDIDQLPH 317
Cdd:PRK04537 249 LGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKY 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 318 VVNFDLPNVPEDYVHRIGRTGRAGATGEAVSLVCVDEKQLLRDIERLIKREIPQEVIAGFEPDPNAKPEPIQQRRGQQQP 397
Cdd:PRK04537 329 VYNYDLPFDAEDYVHRIGRTARLGEEGDAISFACERYAMSLPDIEAYIEQKIPVEPVTAELLTPLPRPPRVPVEGEEADD 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 398 RGGGGGGNRQPRA-------------------GGSGQPAAKRDGHAQPKAAQQKA---AKPRTQGGAGAGGNGGGRPAGG 455
Cdd:PRK04537 409 EAGDSVGTIFREAreqraaeeqrrgggrsgpgGGSRSGSVGGGGRRDGAGADGKPrprRKPRVEGEADAAAAGAETPVVA 488
|
490 500
....*....|....*....|....*...
gi 736058015 456 GNGARPANGNAA---HANRNRSSRSGQR 480
Cdd:PRK04537 489 AAAAQAPGVVAAdgeRAPRKRRRRRNGR 516
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
2-373 |
1.05e-84 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 266.31 E-value: 1.05e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 2 SFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTFYaehrgakRAVRALI 81
Cdd:PTZ00424 29 SFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDL-------NACQALI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 82 LTPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADR 161
Cdd:PTZ00424 102 LAPTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 162 MLDMGFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALIEVARRNTTAESVAQKIHPVDRDR-KRELLTHL 240
Cdd:PTZ00424 182 MLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKEEwKFDTLCDL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 241 IREHNWFQVLVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARGIDIDQLPHVVN 320
Cdd:PTZ00424 262 YETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVIN 341
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 736058015 321 FDLPNVPEDYVHRIGRTGRAGATGEAVSLVCVDEKQLLRDIERLIK---REIPQEV 373
Cdd:PTZ00424 342 YDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIERHYNtqiEEMPMEV 397
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
1-374 |
6.05e-84 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 268.19 E-value: 6.05e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 1 MSFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTFYAEHRGAKRAVRAL 80
Cdd:PLN00206 121 LSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCTIRSGHPSEQRNPLAM 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 81 ILTPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEAD 160
Cdd:PLN00206 201 VLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSKHDIELDNVSVLVLDEVD 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 161 RMLDMGFIHDIKRVLAKLpPQRQNLLFSATFSDEIKALADSLLDSPALIEVARRNTTAESVAQKIHPVDRDRKRELLTHL 240
Cdd:PLN00206 281 CMLERGFRDQVMQIFQAL-SQPQVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKKQKLFDI 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 241 IREHNWFQ--VLVFTRTKHGANRLAEQLTK-DGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARGIDIDQLPH 317
Cdd:PLN00206 360 LKSKQHFKppAVVFVSSRLGADLLANAITVvTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQ 439
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 318 VVNFDLPNVPEDYVHRIGRTGRAGATGEAVSLVCVDEKQLLRDIERLIKRE---IPQEVI 374
Cdd:PLN00206 440 VIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDRNLFPELVALLKSSgaaIPRELA 499
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
2-204 |
6.13e-78 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 242.78 E-value: 6.13e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 2 SFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHT-FYAEHRGAKRAV--R 78
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEdGPPSVGRGRRKAypS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 79 ALILTPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDE 158
Cdd:cd17967 81 ALILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKFLVLDE 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 736058015 159 ADRMLDMGFIHDIKRVLAK--LPP--QRQNLLFSATFSDEIKALADSLLD 204
Cdd:cd17967 161 ADRMLDMGFEPQIRKIVEHpdMPPkgERQTLMFSATFPREIQRLAADFLK 210
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
12-206 |
4.36e-74 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 231.76 E-value: 4.36e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 12 LVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLhtfyaEHRGAKRAV-RALILTPTRELAA 90
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERL-----LYRPKKKAAtRVLVLVPTRELAM 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 91 QVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQ-KTIDLSDLDILVLDEADRMLDMGFIH 169
Cdd:cd17947 76 QCFSVLQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNsPSFDLDSIEILVLDEADRMLEEGFAD 155
|
170 180 190
....*....|....*....|....*....|....*..
gi 736058015 170 DIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSP 206
Cdd:cd17947 156 ELKEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKP 192
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
3-210 |
2.64e-70 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 222.48 E-value: 2.64e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 3 FESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLhtfyaehRGAKRAVRALIL 82
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRL-------SEDPYGIFALVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 83 TPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQ---QKTIDLSDLDILVLDEA 159
Cdd:cd17955 74 TPTRELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRssdDTTKVLSRVKFLVLDEA 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 736058015 160 DRMLDMGFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALIE 210
Cdd:cd17955 154 DRLLTGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPFFWE 204
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
1-203 |
5.47e-69 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 220.99 E-value: 5.47e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 1 MSFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRL--HTFYAEHRGAKRAVR 78
Cdd:cd18052 43 LTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMmkEGLTASSFSEVQEPQ 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 79 ALILTPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDE 158
Cdd:cd18052 123 ALIVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGKISLSKLKYLILDE 202
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 736058015 159 ADRMLDMGFIHDIKRVLAKL--PP--QRQNLLFSATFSDEIKALADSLL 203
Cdd:cd18052 203 ADRMLDMGFGPEIRKLVSEPgmPSkeDRQTLMFSATFPEEIQRLAAEFL 251
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
2-210 |
9.40e-68 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 215.64 E-value: 9.40e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 2 SFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTfyaehrgAKRAVRALI 81
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLE-------NPQRFFALV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 82 LTPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQ-KTIDLSDLDILVLDEAD 160
Cdd:cd17954 74 LAPTRELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENtKGFSLKSLKFLVMDEAD 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 736058015 161 RMLDMGFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALIE 210
Cdd:cd17954 154 RLLNMDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKIE 203
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
2-209 |
3.05e-66 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 211.78 E-value: 3.05e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 2 SFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTfyaehRGAKRAVRALI 81
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKA-----HSPTVGARALI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 82 LTPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADR 161
Cdd:cd17959 77 LSPTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADR 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 736058015 162 MLDMGFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALI 209
Cdd:cd17959 157 LFEMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
3-206 |
7.96e-65 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 208.33 E-value: 7.96e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 3 FESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQrlhtfyaehrgakrAVRALIL 82
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQ--------------IVVALIL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 83 TPTRELAAQVEESVRAYSKYL---KLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEA 159
Cdd:cd17938 67 EPSRELAEQTYNCIENFKKYLdnpKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEA 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 736058015 160 DRMLDMGFIHDIKRVLAKLP-----PQR-QNLLFSATF-SDEIKALADSLLDSP 206
Cdd:cd17938 147 DRLLSQGNLETINRIYNRIPkitsdGKRlQVIVCSATLhSFEVKKLADKIMHFP 200
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
3-209 |
4.24e-64 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 205.99 E-value: 4.24e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 3 FESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTfyaehrgAKRAVRALIL 82
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDP-------KKDVIQALIL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 83 TPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRM 162
Cdd:cd17940 74 VPTRELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKL 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 736058015 163 LDMGFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALI 209
Cdd:cd17940 154 LSQDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEI 200
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
12-209 |
1.70e-61 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 199.13 E-value: 1.70e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 12 LVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILqrLHTFYAEHRGAKRAVRALILTPTRELAAQ 91
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAI--VHINAQPPLERGDGPIVLVLAPTRELAQQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 92 VEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRMLDMGFIHDI 171
Cdd:cd17966 79 IQQEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEPQI 158
|
170 180 190
....*....|....*....|....*....|....*...
gi 736058015 172 KRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALI 209
Cdd:cd17966 159 RKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQV 196
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
25-198 |
1.97e-60 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 195.15 E-value: 1.97e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 25 TPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLhtfyaehRGAKRAVRALILTPTRELAAQVEESVRAYSKYLK 104
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEAL-------DKLDNGPQALVLAPTRELAEQIYEELKKLGKGLG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 105 LRSTVMFGGVSINPQIDALKrGVDIVVATPGRLLDHMQQKTIdLSDLDILVLDEADRMLDMGFIHDIKRVLAKLPPQRQN 184
Cdd:pfam00270 74 LKVASLLGGDSRKEQLEKLK-GPDILVGTPGRLLDLLQERKL-LKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQI 151
|
170
....*....|....
gi 736058015 185 LLFSATFSDEIKAL 198
Cdd:pfam00270 152 LLLSATLPRNLEDL 165
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
221-350 |
4.51e-60 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 193.11 E-value: 4.51e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 221 VAQKIHPVD-RDRKRELLTHLIREHNWFQVLVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRALAEFKNSTLQV 299
Cdd:cd18787 1 IKQLYVVVEeEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 736058015 300 LVATDIAARGIDIDQLPHVVNFDLPNVPEDYVHRIGRTGRAGATGEAVSLV 350
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
6-211 |
8.04e-60 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 195.67 E-value: 8.04e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 6 LGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQrlhtfyaeHRGAKRAVR------A 79
Cdd:cd17953 17 CGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFR--------HIKDQRPVKpgegpiG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 80 LILTPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHM---QQKTIDLSDLDILVL 156
Cdd:cd17953 89 LIMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILtanNGRVTNLRRVTYVVL 168
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 736058015 157 DEADRMLDMGFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPalIEV 211
Cdd:cd17953 169 DEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKP--IEI 221
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
2-213 |
1.46e-59 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 196.03 E-value: 1.46e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 2 SFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHT------FYAEHRGAKR 75
Cdd:cd18051 22 TFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEqgpgesLPSESGYYGR 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 76 AVR---ALILTPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLD 152
Cdd:cd18051 102 RKQyplALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLERGKIGLDYCK 181
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736058015 153 ILVLDEADRMLDMGFIHDIKRVLAK--LPP--QRQNLLFSATFSDEIKALADSLLDSPALIEVAR 213
Cdd:cd18051 182 YLVLDEADRMLDMGFEPQIRRIVEQdtMPPtgERQTLMFSATFPKEIQMLARDFLDNYIFLAVGR 246
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
12-205 |
2.73e-58 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 191.26 E-value: 2.73e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 12 LVKAVNELGYTSPTPIQQQAIPAVLGGG-DLLAGAQTGTGKTAGFTLPILQRLHTFYAehRGAKRAVRALILTPTRELAA 90
Cdd:cd17964 5 LLKALTRMGFETMTPVQQKTLKPILSTGdDVLARAKTGTGKTLAFLLPAIQSLLNTKP--AGRRSGVSALIISPTRELAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 91 QVEESVRAYSKYL-KLRSTVMFGGVSINPQIDALKR-GVDIVVATPGRLLDHMQQ--KTIDLSDLDILVLDEADRMLDMG 166
Cdd:cd17964 83 QIAAEAKKLLQGLrKLRVQSAVGGTSRRAELNRLRRgRPDILVATPGRLIDHLENpgVAKAFTDLDYLVLDEADRLLDMG 162
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 736058015 167 FIHDIKRVLAKLPP----QRQNLLFSATFSDEIKALADSLLDS 205
Cdd:cd17964 163 FRPDLEQILRHLPEknadPRQTLLFSATVPDEVQQIARLTLKK 205
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
12-209 |
9.73e-58 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 189.55 E-value: 9.73e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 12 LVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILqrLHTFYAEHRGAKRAVRALILTPTRELAAQ 91
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPML--VHIMDQRELEKGEGPIAVIVAPTRELAQQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 92 VEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRMLDMGFIHDI 171
Cdd:cd17952 79 IYLEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQV 158
|
170 180 190
....*....|....*....|....*....|....*...
gi 736058015 172 KRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALI 209
Cdd:cd17952 159 RSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
12-209 |
1.03e-57 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 190.22 E-value: 1.03e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 12 LVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLH-----TFYAEHRGAkravRALILTPTR 86
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISrlpplDEETKDDGP----YALILAPTR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 87 ELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRMLDMG 166
Cdd:cd17945 77 ELAQQIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMG 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 736058015 167 FIHDIKRVLAKLPPQ--------------------RQNLLFSATFSDEIKALADSLLDSPALI 209
Cdd:cd17945 157 FEPQVTKILDAMPVSnkkpdteeaeklaasgkhryRQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
12-199 |
8.37e-57 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 187.40 E-value: 8.37e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 12 LVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLhtFYAEHRGAKRAVRALILTPTRELAAQ 91
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEIL--LKRKANLKKGQVGALIISPTRELATQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 92 VEESVRAYSKY--LKLRSTVMFGGVSINPQIDALKR-GVDIVVATPGRLLD--HMQQKTIDLSDLDILVLDEADRMLDMG 166
Cdd:cd17960 79 IYEVLQSFLEHhlPKLKCQLLIGGTNVEEDVKKFKRnGPNILVGTPGRLEEllSRKADKVKVKSLEVLVLDEADRLLDLG 158
|
170 180 190
....*....|....*....|....*....|...
gi 736058015 167 FIHDIKRVLAKLPPQRQNLLFSATFSDEIKALA 199
Cdd:cd17960 159 FEADLNRILSKLPKQRRTGLFSATQTDAVEELI 191
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
12-211 |
4.84e-56 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 185.10 E-value: 4.84e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 12 LVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLhtfyAEHRgAKRAVRALILTPTRELAAQ 91
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKL----GKPR-KKKGLRALILAPTRELASQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 92 VEESVRAYSKYLKLRSTVMFGG-VSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRMLDMGFIHD 170
Cdd:cd17957 76 IYRELLKLSKGTGLRIVLLSKSlEAKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFREQ 155
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 736058015 171 IKRVLAKLP-PQRQNLLFSATFSDEIKALADSLLDSPALIEV 211
Cdd:cd17957 156 TDEILAACTnPNLQRSLFSATIPSEVEELARSVMKDPIRIIV 197
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
14-211 |
9.60e-56 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 184.42 E-value: 9.60e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 14 KAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLhtfYAEHRGAKRAVRALILTPTRELAAQVE 93
Cdd:cd17941 3 KGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKL---YRERWTPEDGLGALIISPTRELAMQIF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 94 ESVRAYSKYLKLRSTVMFGGVSINPQIDALKRgVDIVVATPGRLLDHMQQK-TIDLSDLDILVLDEADRMLDMGFIHDIK 172
Cdd:cd17941 80 EVLRKVGKYHSFSAGLIIGGKDVKEEKERINR-MNILVCTPGRLLQHMDETpGFDTSNLQMLVLDEADRILDMGFKETLD 158
|
170 180 190
....*....|....*....|....*....|....*....
gi 736058015 173 RVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALIEV 211
Cdd:cd17941 159 AIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISV 197
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
12-209 |
3.06e-53 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 177.66 E-value: 3.06e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 12 LVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILqrLHTFY-AEHRGAKRAVRALILTPTRELAA 90
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGF--IHLDLqPIPREQRNGPGVLVLTPTRELAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 91 QVEESVRAYSkYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRMLDMGFIHD 170
Cdd:cd17958 79 QIEAECSKYS-YKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEPQ 157
|
170 180 190
....*....|....*....|....*....|....*....
gi 736058015 171 IKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALI 209
Cdd:cd17958 158 IRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
16-211 |
4.20e-53 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 177.68 E-value: 4.20e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 16 VNELGYTSPTPIQQQAIPAVL-GGGDLLAGAQTGTGKTAGFTLPILQRLHtfyaehrgAKRAVRALILTPTRELAAQVEE 94
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLsGLRDVILAAPTGSGKTLAALLPALEALK--------RGKGGRVLVLVPTRELAEQWAE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 95 SVRAYSKYLKLRSTVMFGGVSINPQIDALKRGV-DIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRMLDMGFIHDIKR 173
Cdd:smart00487 73 ELKKLGPSLGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEK 152
|
170 180 190
....*....|....*....|....*....|....*...
gi 736058015 174 VLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALIEV 211
Cdd:smart00487 153 LLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDV 190
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
12-207 |
6.74e-53 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 177.01 E-value: 6.74e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 12 LVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTFYAEhRGAKRAVRALILTPTRELAAQ 91
Cdd:cd17961 5 LLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAE-SGEEQGTRALILVPTRELAQQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 92 VEESVRAYSKYL--KLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTI-DLSDLDILVLDEADRMLDMGFI 168
Cdd:cd17961 84 VSKVLEQLTAYCrkDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLlLLSTLKYLVIDEADLVLSYGYE 163
|
170 180 190
....*....|....*....|....*....|....*....
gi 736058015 169 HDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPA 207
Cdd:cd17961 164 EDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPA 202
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
20-209 |
5.04e-52 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 174.66 E-value: 5.04e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 20 GYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTFyaehrgaKRAVRALILTPTRELAAQVEESVRAY 99
Cdd:cd17962 9 GYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTE-------HRNPSALILTPTRELAVQIEDQAKEL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 100 SK-YLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRMLDMGFIHDIKRVLAKL 178
Cdd:cd17962 82 MKgLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQQVLDILENI 161
|
170 180 190
....*....|....*....|....*....|.
gi 736058015 179 PPQRQNLLFSATFSDEIKALADSLLDSPALI 209
Cdd:cd17962 162 SHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
6-209 |
1.83e-51 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 173.28 E-value: 1.83e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 6 LGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTfyaehrgAKRAVRALILTPT 85
Cdd:cd17939 2 MGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDT-------TVRETQALVLAPT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 86 RELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRMLDM 165
Cdd:cd17939 75 RELAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSR 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 736058015 166 GFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALI 209
Cdd:cd17939 155 GFKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRI 198
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
12-209 |
5.95e-51 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 172.39 E-value: 5.95e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 12 LVKAVNE-LGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTFYAEHrgaKR--AVRALILTPTREL 88
Cdd:cd17949 1 LVSHLKSkMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRV---DRsdGTLALVLVPTREL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 89 AAQVEESVRaysKYLK----LRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQ-KTIDLSDLDILVLDEADRML 163
Cdd:cd17949 78 ALQIYEVLE---KLLKpfhwIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNtQSFDVSNLRWLVLDEADRLL 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 736058015 164 DMGFIHDIKRVLAKL-------------PPQRQNLLFSATFSDEIKALADSLLDSPALI 209
Cdd:cd17949 155 DMGFEKDITKILELLddkrskaggekskPSRRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
1-203 |
6.29e-50 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 170.58 E-value: 6.29e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 1 MSFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLP-ILQRLHTFYAEHRGAKRAvra 79
Cdd:cd18049 24 LNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPaIVHINHQPFLERGDGPIC--- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 80 LILTPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEA 159
Cdd:cd18049 101 LVLAPTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEA 180
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 736058015 160 DRMLDMGFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLL 203
Cdd:cd18049 181 DRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFL 224
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
12-192 |
8.47e-50 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 170.11 E-value: 8.47e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 12 LVKAVNELGYTSPTPIQQQAIP-AVLGGGDLLAGAQTGTGKTAGFTLPILQRL--HTFYAEHRGAKRAVRALILTPTREL 88
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPaAIRDGKDVIGAAETGSGKTLAFGIPILERLlsQKSSNGVGGKQKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 89 AAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQK---TIDLSDLDILVLDEADRMLDM 165
Cdd:cd17946 81 AVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGnehLANLKSLRFLVLDEADRMLEK 160
|
170 180 190
....*....|....*....|....*....|....
gi 736058015 166 GFIHDIKRVLAKLP-------PQRQNLLFSATFS 192
Cdd:cd17946 161 GHFAELEKILELLNkdragkkRKRQTFVFSATLT 194
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
12-209 |
8.16e-49 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 166.36 E-value: 8.16e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 12 LVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILqrLHTFYAEHRGAKRAVR---ALILTPTREL 88
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLI--MFALEQEKKLPFIKGEgpyGLIVCPSREL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 89 AAQVEESVRAYSKYLK------LRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRM 162
Cdd:cd17951 79 ARQTHEVIEYYCKALQeggypqLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRM 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 736058015 163 LDMGFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALI 209
Cdd:cd17951 159 IDMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
13-209 |
1.21e-48 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 165.61 E-value: 1.21e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 13 VKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTFYAEHRgakRAVRALILTPTRELAAQV 92
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKLKFKPR---NGTGVIIISPTRELALQI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 93 EESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKT-IDLSDLDILVLDEADRMLDMGFIHDI 171
Cdd:cd17942 79 YGVAKELLKYHSQTFGIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKgFLYKNLQCLIIDEADRILEIGFEEEM 158
|
170 180 190
....*....|....*....|....*....|....*....
gi 736058015 172 KRVLAKLPPQRQNLLFSATFSDEIKALAD-SLLDSPALI 209
Cdd:cd17942 159 RQIIKLLPKRRQTMLFSATQTRKVEDLARiSLKKKPLYV 197
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
2-211 |
2.40e-48 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 165.21 E-value: 2.40e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 2 SFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTFYAEhrgakraVRALI 81
Cdd:cd17950 3 GFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQ-------VSVLV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 82 LTPTRELAAQVEESVRAYSKYLK-LRSTVMFGGVSINPQIDALKRGV-DIVVATPGRLLDHMQQKTIDLSDLDILVLDEA 159
Cdd:cd17950 76 ICHTRELAFQISNEYERFSKYMPnVKTAVFFGGVPIKKDIEVLKNKCpHIVVGTPGRILALVREKKLKLSHVKHFVLDEC 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 736058015 160 DRM---LDMGfiHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALIEV 211
Cdd:cd17950 156 DKMleqLDMR--RDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
21-212 |
2.03e-46 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 162.49 E-value: 2.03e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 21 YTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRL-HTFYAEhRGAKRAvrALILTPTRELAAQVEESVRAY 99
Cdd:cd18050 82 FKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHInHQPYLE-RGDGPI--CLVLAPTRELAQQVQQVADDY 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 100 SKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRMLDMGFIHDIKRVLAKLP 179
Cdd:cd18050 159 GKSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIR 238
|
170 180 190
....*....|....*....|....*....|...
gi 736058015 180 PQRQNLLFSATFSDEIKALADSLLDSPALIEVA 212
Cdd:cd18050 239 PDRQTLMWSATWPKEVRQLAEDFLRDYVQINIG 271
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
3-209 |
1.59e-45 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 157.63 E-value: 1.59e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 3 FESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTfyaehrgAKRAVRALIL 82
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDI-------QVRETQALIL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 83 TPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRM 162
Cdd:cd18045 74 SPTRELAVQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEM 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 736058015 163 LDMGF---IHDIKRVlakLPPQRQNLLFSATFSDEIKALADSLLDSPALI 209
Cdd:cd18045 154 LNKGFkeqIYDVYRY---LPPATQVVLVSATLPQDILEMTNKFMTDPIRI 200
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
3-209 |
2.08e-45 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 157.22 E-value: 2.08e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 3 FESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTfyaehrgAKRAVRALIL 82
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDT-------SLKATQALVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 83 TPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRM 162
Cdd:cd18046 74 APTRELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEM 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 736058015 163 LDMGFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALI 209
Cdd:cd18046 154 LSRGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRI 200
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
8-202 |
6.06e-43 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 150.42 E-value: 6.06e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 8 LAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGD--LLAGAQTGTGKTAGFTLPILQRLHTfyaehrgAKRAVRALILTPT 85
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDPPenLIAQSQSGTGKTAAFVLAMLSRVDP-------TLKSPQALCLAPT 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 86 RELAAQVEESVRAYSKYLKLRSTVMFGGVSINPqidalKRGVD--IVVATPGRLLDHMQQKTIDLSDLDILVLDEADRML 163
Cdd:cd17963 74 RELARQIGEVVEKMGKFTGVKVALAVPGNDVPR-----GKKITaqIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVML 148
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 736058015 164 DM-GFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSL 202
Cdd:cd17963 149 DTqGHGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKI 188
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
13-190 |
9.07e-43 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 150.38 E-value: 9.07e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 13 VKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTfYAEHRGAKRAVRALILTPTRELAAQV 92
Cdd:cd17944 2 IKLLQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQE-DQQPRKRGRAPKVLVLAPTRELANQV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 93 EESVRAYSKylKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRMLDMGF---IH 169
Cdd:cd17944 81 TKDFKDITR--KLSVACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFaeqVE 158
|
170 180
....*....|....*....|...
gi 736058015 170 DIKRVLAKLPPQR--QNLLFSAT 190
Cdd:cd17944 159 EILSVSYKKDSEDnpQTLLFSAT 181
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
12-210 |
3.29e-40 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 143.17 E-value: 3.29e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 12 LVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLhtfyaehRGAKRAVRALILTPTRELAAQ 91
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESL-------DLERRHPQVLILAPTREIAVQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 92 VEESVRAYSKYLK-LRSTVMFGGVSINPQIDALKRgVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRMLDMGFIHD 170
Cdd:cd17943 74 IHDVFKKIGKKLEgLKCEVFIGGTPVKEDKKKLKG-CHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQKD 152
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 736058015 171 IKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALIE 210
Cdd:cd17943 153 VNWIFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPVLVR 192
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
12-209 |
1.05e-37 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 137.76 E-value: 1.05e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 12 LVKAVNELGYTSPTPIQQQAIPAVLGG---------GDLLAGAQTGTGKTAGFTLPILQRLHTfyaehRGAKRaVRALIL 82
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIVQALSK-----RVVPR-LRALIV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 83 TPTRELAAQVEESVRAYSKYLKLRsTVMFGG-VSINPQIDALKRG--------VDIVVATPGRLLDHMQQKT-IDLSDLD 152
Cdd:cd17956 75 VPTKELVQQVYKVFESLCKGTGLK-VVSLSGqKSFKKEQKLLLVDtsgrylsrVDILVATPGRLVDHLNSTPgFTLKHLR 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736058015 153 ILVLDEADRMLDMGF-------IHDIKR-------------VLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALI 209
Cdd:cd17956 154 FLVIDEADRLLNQSFqdwletvMKALGRptapdlgsfgdanLLERSVRPLQKLLFSATLTRDPEKLSSLKLHRPRLF 230
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
12-191 |
6.57e-34 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 127.48 E-value: 6.57e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 12 LVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTFYAEHRGAKRAVRALILTPTRELAAQ 91
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEGPFNAPRGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 92 VEESVRAYSKYLKLRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRMLDMGFIHDI 171
Cdd:cd17948 81 IGSVAQSLTEGLGLKVKVITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDSFNEKL 160
|
170 180 190
....*....|....*....|....*....|...
gi 736058015 172 KRVLAKLP-------------PQRQNLLFSATF 191
Cdd:cd17948 161 SHFLRRFPlasrrsentdgldPGTQLVLVSATM 193
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
233-341 |
2.75e-33 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 121.55 E-value: 2.75e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 233 KRELLTHLIREHNWFQVLVFTRTKhgaNRLAEQ--LTKDGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARGI 310
Cdd:pfam00271 2 KLEALLELLKKERGGKVLIFSQTK---KTLEAEllLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 736058015 311 DIDQLPHVVNFDLPNVPEDYVHRIGRTGRAG 341
Cdd:pfam00271 79 DLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
2-217 |
2.89e-31 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 120.13 E-value: 2.89e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 2 SFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGG--GDLLAGAQTGTGKTAGFTLPILQRLHtfyaehrGAKRAVRA 79
Cdd:cd18048 19 SFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVD-------ALKLYPQC 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 80 LILTPTRELAAQVEESVRAYSKY-------LKLRSTVMFGGVSINPQIdalkrgvdiVVATPGRLLDH-MQQKTIDLSDL 151
Cdd:cd18048 92 LCLSPTFELALQTGKVVEEMGKFcvgiqviYAIRGNRPGKGTDIEAQI---------VIGTPGTVLDWcFKLRLIDVTNI 162
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736058015 152 DILVLDEADRMLDM-GFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALIEVARRNTT 217
Cdd:cd18048 163 SVFVLDEADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNIIKLKKEELT 229
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
261-341 |
6.45e-27 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 103.45 E-value: 6.45e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 261 RLAEQLTKDGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARGIDIDQLPHVVNFDLPNVPEDYVHRIGRTGRA 340
Cdd:smart00490 2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRA 81
|
.
gi 736058015 341 G 341
Cdd:smart00490 82 G 82
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
3-196 |
1.34e-25 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 105.15 E-value: 1.34e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 3 FESLGLAePLVKAV----------NELGYTSPTPIQQQAIPAVLGGGD-----------------LLAgAQTGTGKTAGF 55
Cdd:cd17965 1 FDQLKLL-PSVREAiikeilkgsnKTDEEIKPSPIQTLAIKKLLKTLMrkvtkqtsneepklevfLLA-AETGSGKTLAY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 56 TLPILQRL-----------HTFYAEHRGAKRaVRALILTPTRELAAQVEESVRAYSKYLKLRSTVMFG--GVSINPQIDA 122
Cdd:cd17965 79 LAPLLDYLkrqeqepfeeaEEEYESAKDTGR-PRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSgfGPSYQRLQLA 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 736058015 123 LKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADRMLDMGFIHDIKRVLAKLPPQRQNLLFSATFSDEIK 196
Cdd:cd17965 158 FKGRIDILVTTPGKLASLAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIPKEFD 231
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
2-210 |
5.10e-25 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 102.11 E-value: 5.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 2 SFESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGG--GDLLAGAQTGTGKTAGFTLPILQRLHTfyaehrgAKRAVRA 79
Cdd:cd18047 2 SFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEP-------ANKYPQC 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 80 LILTPTRELAAQVEESVRAYSKY-------LKLRSTVMFGGVSINPQidalkrgvdIVVATPGRLLDH-MQQKTIDLSDL 151
Cdd:cd18047 75 LCLSPTYELALQTGKVIEQMGKFypelklaYAVRGNKLERGQKISEQ---------IVIGTPGTVLDWcSKLKFIDPKKI 145
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 152 DILVLDEADRML-DMGFIHDIKRVLAKLPPQRQNLLFSATFSDEIKALADSLLDSPALIE 210
Cdd:cd18047 146 KVFVLDEADVMIaTQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIK 205
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
26-387 |
1.66e-21 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 97.40 E-value: 1.66e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 26 PIQQQAIPAVL-----GGGDLLAGAQTGTGKT--AGFtlpILQRLHtfyaehrgakRAVRALILTPTRELAAQveesvrA 98
Cdd:COG1061 83 PYQQEALEALLaalerGGGRGLVVAPTGTGKTvlALA---LAAELL----------RGKRVLVLVPRRELLEQ------W 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 99 YSKYLKLRSTVMFGGvsinpqiDALKRGVDIVVATPGRLLDHMQQKTIDlSDLDILVLDEADRMLDMGFihdiKRVLAKL 178
Cdd:COG1061 144 AEELRRFLGDPLAGG-------GKKDSDAPITVATYQSLARRAHLDELG-DRFGLVIIDEAHHAGAPSY----RRILEAF 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 179 PPQRQnLLFSAT--FSDEI-----------------KALADSLLDSPALIEV--------ARRNTTAESVAQKIHPVDRd 231
Cdd:COG1061 212 PAAYR-LGLTATpfRSDGReillflfdgivyeyslkEAIEDGYLAPPEYYGIrvdltderAEYDALSERLREALAADAE- 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 232 RKRELLTHLIREH-NWFQVLVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARGI 310
Cdd:COG1061 290 RKDKILRELLREHpDDRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGV 369
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 311 DIDQLPHVVNFDLPNVPEDYVHRIGRTGRAGATGEAVS---LVCVDEKQLLRDIERLIKREIPQEVIAGFEPDPNAKPEP 387
Cdd:COG1061 370 DVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGKEDALvydFVGNDVPVLEELAKDLRDLAGYRVEFLDEEESEELALLI 449
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
1-373 |
4.72e-18 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 86.87 E-value: 4.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 1 MSFESLGLAEpLVKAVNELGYTSPTPIQQQAIPA-VLGGGDLLAGAQTGTGKTAGFTLPILQRLhtfyaehrgaKRAVRA 79
Cdd:COG1204 1 MKVAELPLEK-VIEFLKERGIEELYPPQAEALEAgLLEGKNLVVSAPTASGKTLIAELAILKAL----------LNGGKA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 80 LILTPTRELAAQVEESVRAYSKYLKLRSTVMFGGVSINpqiDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEA 159
Cdd:COG1204 70 LYIVPLRALASEKYREFKRDFEELGIKVGVSTGDYDSD---DEWLGRYDILVATPEKLDSLLRNGPSWLRDVDLVVVDEA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 160 DrmldmgFIHDIKR------VLAKL---PPQRQNLLFSATFSDeIKALADsLLDSPaLIEVARRnttaeSVAQKI----- 225
Cdd:COG1204 147 H------LIDDESRgptlevLLARLrrlNPEAQIVALSATIGN-AEEIAE-WLDAE-LVKSDWR-----PVPLNEgvlyd 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 226 --------HPVDRDRKRELLTHLIREHnwFQVLVFTRTKHGANRLAEQLTK--------------DGISAMAI------- 276
Cdd:COG1204 213 gvlrfddgSRRSKDPTLALALDLLEEG--GQVLVFVSSRRDAESLAKKLADelkrrltpeereelEELAEELLevseeth 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 277 ----------------HGNKSQSARTRALAEFKNSTLQVLVATDIAARGIDidqLP--HVV--------NFDLPnvPEDY 330
Cdd:COG1204 291 tnekladclekgvafhHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVN---LParRVIirdtkrggMVPIP--VLEF 365
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 736058015 331 VHRIGRTGRAGA--TGEAVsLVCVDEKQLLRDIERLIKREiPQEV 373
Cdd:COG1204 366 KQMAGRAGRPGYdpYGEAI-LVAKSSDEADELFERYILGE-PEPI 408
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
38-190 |
1.08e-17 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 79.75 E-value: 1.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 38 GGDLLAGAQTGTGKTAGFTLPILQRLhtfyaehrgAKRAVRALILTPTRELAAQVEESVRAYSKyLKLRSTVMFGGVSIN 117
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLL---------LKKGKKVLVLVPTKALALQTAERLRELFG-PGIRVAVLVGGSSAE 70
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736058015 118 PQIDALKRGVDIVVATPGRLLDHMQQ-KTIDLSDLDILVLDEADRMLDMGFIHDIK--RVLAKLPPQRQNLLFSAT 190
Cdd:cd00046 71 EREKNKLGDADIIIATPDMLLNLLLReDRLFLKDLKLIIVDEAHALLIDSRGALILdlAVRKAGLKNAQVILLSAT 146
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
7-347 |
1.17e-17 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 86.04 E-value: 1.17e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 7 GLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLhtfyAEHRGAkravRALILTPTR 86
Cdd:COG1205 40 WLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEAL----LEDPGA----TALYLYPTK 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 87 ELAAQVEESVRAYSKYL--KLRSTVMFGGVSINPQIDALKRGvDIVVATP-----GRLLDHMQQKTIdLSDLDILVLDEA 159
Cdd:COG1205 112 ALARDQLRRLRELAEALglGVRVATYDGDTPPEERRWIREHP-DIVLTNPdmlhyGLLPHHTRWARF-FRNLRYVVIDEA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 160 ---------------DRMldmgfihdiKRVLAKLPPQRQNLLFSAT-----------FSDEIKALADS----------LL 203
Cdd:COG1205 190 htyrgvfgshvanvlRRL---------RRICRHYGSDPQFILASATignpaehaerlTGRPVTVVDEDgsprgertfvLW 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 204 DSPALIEVARRNTTAESvaqkihpvdrdrkRELLTHLIREHnwFQVLVFTRTKHGANRLAEQL---TKDGISAMAIHGNK 280
Cdd:COG1205 261 NPPLVDDGIRRSALAEA-------------ARLLADLVREG--LRTLVFTRSRRGAELLARYArraLREPDLADRVAAYR 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 281 SQ-SARTRALAE--FKNSTLQVLVATDIAARGIDIDQLPHVVNFDLPNVPEDYVHRIGRTGRAGATGEAV 347
Cdd:COG1205 326 AGyLPEERREIErgLRSGELLGVVSTNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDSLVV 395
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
20-372 |
6.15e-16 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 80.18 E-value: 6.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 20 GYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTfyaehrgakravrALILTPtreLAA----QVEE- 94
Cdd:COG0514 14 GYDSFRPGQEEIIEAVLAGRDALVVMPTGGGKSLCYQLPALLLPGL-------------TLVVSP---LIAlmkdQVDAl 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 95 ---SVRAYSkylkLRStvmfggvSINPQ-----IDALKRG-VDIVVATPGRLldhMQQKTID-LSDLDI--LVLDEADRM 162
Cdd:COG0514 78 raaGIRAAF----LNS-------SLSAEerrevLRALRAGeLKLLYVAPERL---LNPRFLElLRRLKIslFAIDEAHCI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 163 LDMGfiHD-------IKRVLAKLP-PQRqnLLFSATFSDEIKA-LADSL-LDSPALIE--VARRNTTAEsvaqkIHPVDR 230
Cdd:COG0514 144 SQWG--HDfrpdyrrLGELRERLPnVPV--LALTATATPRVRAdIAEQLgLEDPRVFVgsFDRPNLRLE-----VVPKPP 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 231 DRKRELLTHLIREHNWFQVLVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATdIA-ARG 309
Cdd:COG0514 215 DDKLAQLLDFLKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT-IAfGMG 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 736058015 310 IDIDQLPHVVNFDLPNVPEDYVHRIGRTGRAGATGEAVSLVCVDEKQLLRdieRLIKREIPQE 372
Cdd:COG0514 294 IDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPEDVAIQR---FFIEQSPPDE 353
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
25-193 |
9.89e-13 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 66.52 E-value: 9.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 25 TPIQQQAIPAVLGGGD-LLAGAQTGTGKTAGFTLPILQRLhtfyAEHRGakravRALILTPTRELAAQVEESVRAYSKYL 103
Cdd:cd17921 3 NPIQREALRALYLSGDsVLVSAPTSSGKTLIAELAILRAL----ATSGG-----KAVYIAPTRALVNQKEADLRERFGPL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 104 KLRSTVMFGGVSINPQIDALKrgvDIVVATPGR---LLDHMQQKTIDlsDLDILVLDEADrmldmgFIHDIKR------V 174
Cdd:cd17921 74 GKNVGLLTGDPSVNKLLLAEA---DILVATPEKldlLLRNGGERLIQ--DVRLVVVDEAH------LIGDGERgvvlelL 142
|
170 180
....*....|....*....|..
gi 736058015 175 LAKLP---PQRQNLLFSATFSD 193
Cdd:cd17921 143 LSRLLrinKNARFVGLSATLPN 164
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
234-350 |
4.10e-11 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 65.52 E-value: 4.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 234 RELLTHLIREHNWFQVLVFTRTKHGANRLAEQLTKDGISAM------AIHGNK--SQSARTRALAEFKNSTLQVLVATDI 305
Cdd:COG1111 341 REILKEQLGTNPDSRIIVFTQYRDTAEMIVEFLSEPGIKAGrfvgqaSKEGDKglTQKEQIEILERFRAGEFNVLVATSV 420
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 736058015 306 AARGIDIDQLPHVVNFDlpNVPED--YVHRIGRTGRAGAtGEAVSLV 350
Cdd:COG1111 421 AEEGLDIPEVDLVIFYE--PVPSEirSIQRKGRTGRKRE-GRVVVLI 464
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
20-363 |
8.62e-11 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 64.35 E-value: 8.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 20 GYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRlhtfyaehRGAKRAVRALIltptRELAAQVEEsVRAY 99
Cdd:PRK11057 22 GYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALVL--------DGLTLVVSPLI----SLMKDQVDQ-LLAN 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 100 SKYLK-LRSTVmfggvSINPQIDALKR----GVDIVVATPGRL-----LDHMQQktidlSDLDILVLDEADRMLDMGfiH 169
Cdd:PRK11057 89 GVAAAcLNSTQ-----TREQQLEVMAGcrtgQIKLLYIAPERLmmdnfLEHLAH-----WNPALLAVDEAHCISQWG--H 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 170 DIK---RVLAKLPPQRQNLLFSA--------TFSDEIKALAdslLDSPaLIEVAR--RNTTAESVAQKIHPVDRdrkrel 236
Cdd:PRK11057 157 DFRpeyAALGQLRQRFPTLPFMAltataddtTRQDIVRLLG---LNDP-LIQISSfdRPNIRYTLVEKFKPLDQ------ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 237 LTHLIREHNWFQVLVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARGIDIDQLP 316
Cdd:PRK11057 227 LMRYVQEQRGKSGIIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVR 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 736058015 317 HVVNFDLPNVPEDYVHRIGRTGRAGATGEAVSLV----------CVDEKQL--LRDIER 363
Cdd:PRK11057 307 FVVHFDIPRNIESYYQETGRAGRDGLPAEAMLFYdpadmawlrrCLEEKPAgqQQDIER 365
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
228-335 |
1.98e-10 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 58.64 E-value: 1.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 228 VDRDRKRELLTHLIREHNWFQ--VLVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRALAEFKN--STLQVLVAT 303
Cdd:cd18793 7 EVVSGKLEALLELLEELREPGekVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEdpDIRVFLLST 86
|
90 100 110
....*....|....*....|....*....|....*...
gi 736058015 304 DIAARGIDIDQLPHVVNFDL---PNVPE---DYVHRIG 335
Cdd:cd18793 87 KAGGVGLNLTAANRVILYDPwwnPAVEEqaiDRAHRIG 124
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
250-341 |
2.92e-10 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 57.99 E-value: 2.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 250 LVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARGIDIDQLPHVVNFDLPNVPED 329
Cdd:cd18794 34 IIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMES 113
|
90
....*....|..
gi 736058015 330 YVHRIGRTGRAG 341
Cdd:cd18794 114 YYQESGRAGRDG 125
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
21-312 |
5.86e-10 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 61.66 E-value: 5.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 21 YTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKT-AGFtLPILQRLHTfYAEHRGAKRAVRALILTPTRELAAQVEESVRAY 99
Cdd:COG1201 22 FGAPTPPQREAWPAIAAGESTLLIAPTGSGKTlAAF-LPALDELAR-RPRPGELPDGLRVLYISPLKALANDIERNLRAP 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 100 SKYLKLRSTVMFGGVSI------NPQID---ALKRGVDIVVATP-----------GRLLdhmqqktidLSDLDILVLDEa 159
Cdd:COG1201 100 LEEIGEAAGLPLPEIRVgvrtgdTPASErqrQRRRPPHILITTPeslallltspdAREL---------LRGVRTVIVDE- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 160 drmldmgfIHDI---KR------------VLAKLPPQRQNLlfSATFSDeIKALADSLL-----DSPALIEV-------- 211
Cdd:COG1201 170 --------IHALagsKRgvhlalslerlrALAPRPLQRIGL--SATVGP-LEEVARFLVgyedpRPVTIVDAgagkkpdl 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 212 ---------ARRNTTAESVAQKIHPvdrdrkreLLTHLIREHNwfQVLVFTRTKHGANRLAEQLTK---DGISAMAI-HG 278
Cdd:COG1201 239 evlvpvedlIERFPWAGHLWPHLYP--------RVLDLIEAHR--TTLVFTNTRSQAERLFQRLNElnpEDALPIAAhHG 308
|
330 340 350
....*....|....*....|....*....|....*..
gi 736058015 279 NKSQSARTRALAEFKNSTLQVLVAT---DIaarGIDI 312
Cdd:COG1201 309 SLSREQRLEVEEALKAGELRAVVATsslEL---GIDI 342
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
47-159 |
1.50e-09 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 57.66 E-value: 1.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 47 TGTGKTAGFTLPILQRLHTFYAEHRGAKRAVralILTPTRELAAQVEESVRAYSKylkLRSTVMFGGVSINPQIDALK-- 124
Cdd:cd18034 25 TGSGKTLIAVMLIKEMGELNRKEKNPKKRAV---FLVPTVPLVAQQAEAIRSHTD---LKVGEYSGEMGVDKWTKERWke 98
|
90 100 110
....*....|....*....|....*....|....*..
gi 736058015 125 --RGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEA 159
Cdd:cd18034 99 elEKYDVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
223-339 |
4.26e-09 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 55.05 E-value: 4.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 223 QKIHPvdrdrKRELLTHLIREHnwFQ---------VLVFTRTKHGANRLAEQLTK--DGISAMAI--HGNK------SQS 283
Cdd:cd18801 5 EKIHP-----KLEKLEEIVKEH--FKkkqegsdtrVIIFSEFRDSAEEIVNFLSKirPGIRATRFigQASGksskgmSQK 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 736058015 284 ARTRALAEFKNSTLQVLVATDIAARGIDIDQLPHVVNFDLPNVPEDYVHRIGRTGR 339
Cdd:cd18801 78 EQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR 133
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
246-344 |
7.32e-09 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 52.32 E-value: 7.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 246 WFQVLVFTRTKHGANRLAEQLtkdgisamaihgnksqsartralaefknstlQVLVATDIAARGIDIDQLPHVVNFDLPN 325
Cdd:cd18785 3 VVKIIVFTNSIEHAEEIASSL-------------------------------EILVATNVLGEGIDVPSLDTVIFFDPPS 51
|
90
....*....|....*....
gi 736058015 326 VPEDYVHRIGRTGRAGATG 344
Cdd:cd18785 52 SAASYIQRVGRAGRGGKDE 70
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
230-337 |
1.73e-08 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 56.77 E-value: 1.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 230 RDRKRELLTHLIREHNW--FQVLVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRALAEFKN--STLQVLVATDI 305
Cdd:COG0553 531 RSAKLEALLELLEELLAegEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEgpEAPVFLISLKA 610
|
90 100 110
....*....|....*....|....*....|....*...
gi 736058015 306 AARGIDIDQLPHVVNFDL---PNVPE---DYVHRIGRT 337
Cdd:COG0553 611 GGEGLNLTAADHVIHYDLwwnPAVEEqaiDRAHRIGQT 648
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
28-159 |
6.44e-08 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 52.59 E-value: 6.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 28 QQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLhtfyAEHRGAkravRALILTPTRELAAQVEESVRAYSKYLKLRS 107
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEAL----LRDPGS----RALYLYPTKALAQDQLRSLRELLEQLGLGI 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 736058015 108 TVMF--GGVSINPQIDALKRGVDIVVATPGRL----LDHMQQKTIDLSDLDILVLDEA 159
Cdd:cd17923 77 RVATydGDTPREERRAIIRNPPRILLTNPDMLhyalLPHHDRWARFLRNLRYVVLDEA 134
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
196-386 |
1.09e-07 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 54.49 E-value: 1.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 196 KAlADSLLDSPALIEVARRNTTAESVaqkiHPvDRDRKRELLTHLIREHNWFQVLVFTRTKHGANRLAEQLTKDGISAMA 275
Cdd:PRK13766 321 KA-SKRLVEDPRFRKAVRKAKELDIE----HP-KLEKLREIVKEQLGKNPDSRIIVFTQYRDTAEKIVDLLEKEGIKAVR 394
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 276 IHG--NK------SQSARTRALAEFKNSTLQVLVATDIAARGIDIdqlPHV--VNFDLPnVPED--YVHRIGRTGRaGAT 343
Cdd:PRK13766 395 FVGqaSKdgdkgmSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDI---PSVdlVIFYEP-VPSEirSIQRKGRTGR-QEE 469
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 736058015 344 GEAVSLVCVD-------------EKQLLRDIERLIKREIPQEVIAGFEPDPNAKPE 386
Cdd:PRK13766 470 GRVVVLIAKGtrdeayywssrrkEKKMKEELKNLKGILNKKLQELDEEQKGEEEEK 525
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
217-312 |
1.61e-07 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 50.71 E-value: 1.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 217 TAESVAQKIHpVDRDRKRELLTHLIREH-NWFQVLVFTRTKHGANRLAEQLTKDgisamAIHGNKSQSARTRALAEFKNS 295
Cdd:cd18789 20 GAHRKRRLLA-AMNPNKLRALEELLKRHeQGDKIIVFTDNVEALYRYAKRLLKP-----FITGETPQSEREEILQNFREG 93
|
90
....*....|....*..
gi 736058015 296 TLQVLVATDIAARGIDI 312
Cdd:cd18789 94 EYNTLVVSKVGDEGIDL 110
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
27-161 |
2.19e-07 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 50.98 E-value: 2.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 27 IQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLhtfyaehrgAKRAVRALILTPTRELAAQVEESVRAYSKyLKLR 106
Cdd:cd18035 5 LYQVLIAAVALNGNTLIVLPTGLGKTIIAILVAADRL---------TKKGGKVLILAPSRPLVEQHAENLKRVLN-IPDK 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 736058015 107 STVMFGGVSINPQIDALKRGvDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADR 161
Cdd:cd18035 75 ITSLTGEVKPEERAERWDAS-KIIVATPQVIENDLLAGRITLDDVSLLIFDEAHH 128
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
230-343 |
4.56e-07 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 49.13 E-value: 4.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 230 RDRKRELLTHLIREH----NWFQVLVFTRTKHGANRLAE-----QLTKDGISA--MAIHGNKSQSAR--------TRALA 290
Cdd:cd18802 5 VIPKLQKLIEILREYfpktPDFRGIIFVERRATAVVLSRllkehPSTLAFIRCgfLIGRGNSSQRKRslmtqrkqKETLD 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 736058015 291 EFKNSTLQVLVATDIAARGIDIDQLPHVVNFDLPNVPEDYVHRIGRTGRAGAT 343
Cdd:cd18802 85 KFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGRARAPNSK 137
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
47-161 |
1.44e-06 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 51.03 E-value: 1.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 47 TGTGKTAGFTLPILQRLHTfyaehRGAKravrALILTPTRELAAQVEESvraYSKYLKLRST--VMFGGvSINP--QIDA 122
Cdd:PRK13766 38 TGLGKTAIALLVIAERLHK-----KGGK----VLILAPTKPLVEQHAEF---FRKFLNIPEEkiVVFTG-EVSPekRAEL 104
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 736058015 123 LKRGvDIVVATP---------GRlldhmqqktIDLSDLDILVLDEADR 161
Cdd:PRK13766 105 WEKA-KVIVATPqviendliaGR---------ISLEDVSLLIFDEAHR 142
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
4-358 |
1.73e-06 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 50.65 E-value: 1.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 4 ESLGLAEPLVKAVNELGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKT-AGFtLPILQRLhTFYAEHRGAKRAVRALIL 82
Cdd:PRK13767 13 EILDLLRPYVREWFKEKFGTFTPPQRYAIPLIHEGKNVLISSPTGSGKTlAAF-LAIIDEL-FRLGREGELEDKVYCLYV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 83 TPTRELAAQV----EESVRAYSKYLK--------LRSTVMFGGVSINPQIDALKRGVDIVVATP---GRLLD--HMQQKt 145
Cdd:PRK13767 91 SPLRALNNDIhrnlEEPLTEIREIAKergeelpeIRVAIRTGDTSSYEKQKMLKKPPHILITTPeslAILLNspKFREK- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 146 idLSDLDILVLDEadrmldmgfIHDI---KR------------VLAKLPPQRQNLlfSATFS--DEI-KALA---DSLLD 204
Cdd:PRK13767 170 --LRTVKWVIVDE---------IHSLaenKRgvhlslslerleELAGGEFVRIGL--SATIEplEEVaKFLVgyeDDGEP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 205 SPALIEVARR----------------NTTAESVAQKIHpvdrdrkrELLTHLIREHNwfQVLVFTRTKHGANRLAEQLTK 268
Cdd:PRK13767 237 RDCEIVDARFvkpfdikvispvddliHTPAEEISEALY--------ETLHELIKEHR--TTLIFTNTRSGAERVLYNLRK 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 269 --------DGIsaMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARGIDIdqlPHVvnfdlpnvpeDYVHRIG----- 335
Cdd:PRK13767 307 rfpeeydeDNI--GAHHSSLSREVRLEVEEKLKRGELKVVVSSTSLELGIDI---GYI----------DLVVLLGspksv 371
|
410 420 430
....*....|....*....|....*....|.
gi 736058015 336 -----RTGRAGATGEAVS---LVCVDEKQLL 358
Cdd:PRK13767 372 srllqRIGRAGHRLGEVSkgrIIVVDRDDLV 402
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
1-311 |
2.18e-06 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 50.27 E-value: 2.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 1 MSFESLGLAEPLVKAVNELGyTSPTPIQQQAIPA-VLGGGDLLAGAQTGTGKtagftlpilqrlhTFYAEHRGAKRAVRA 79
Cdd:COG1202 188 VPVDDLDLPPELKDLLEGRG-EELLPVQSLAVENgLLEGKDQLVVSATATGK-------------TLIGELAGIKNALEG 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 80 ----LILTPTRELAAQVEESVRA-YSKYLKLRSTVmfgGVS-INPQIDALKRGVDIVVAT-PGrlLDHMQQKTIDLSDLD 152
Cdd:COG1202 254 kgkmLFLVPLVALANQKYEDFKDrYGDGLDVSIRV---GASrIRDDGTRFDPNADIIVGTyEG--IDHALRTGRDLGDIG 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 153 ILVLDEAdRMLDM---GFIHD--IKRvLAKLPPQRQNLLFSATFSDEiKALADSLldSPALIEVARRnttaesvaqkihP 227
Cdd:COG1202 329 TVVIDEV-HMLEDperGHRLDglIAR-LKYYCPGAQWIYLSATVGNP-EELAKKL--GAKLVEYEER------------P 391
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 228 VDRDR---------KRELLTHLIREHnwF----------QVLVFTRTKHGANRLAEQLtkdGISAMAIHGNKSQSARTRA 288
Cdd:COG1202 392 VPLERhltfadgreKIRIINKLVKRE--FdtksskgyrgQTIIFTNSRRRCHEIARAL---GYKAAPYHAGLDYGERKKV 466
|
330 340
....*....|....*....|...
gi 736058015 289 LAEFKNSTLQVLVATDIAARGID 311
Cdd:COG1202 467 ERRFADQELAAVVTTAALAAGVD 489
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
239-339 |
7.56e-06 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 45.72 E-value: 7.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 239 HLIREHNwfQVLVFTRTKHGANRLAEQL------TKDGISAMAIHGNKSQSARTRALAEFKNSTLQVLVATDIAARGIDI 312
Cdd:cd18796 33 FLLERHK--STLVFTNTRSQAERLAQRLrelcpdRVPPDFIALHHGSLSRELREEVEAALKRGDLKVVVATSSLELGIDI 110
|
90 100
....*....|....*....|....*..
gi 736058015 313 DQLPHVVNFDLPNVPEDYVHRIGRTGR 339
Cdd:cd18796 111 GDVDLVIQIGSPKSVARLLQRLGRSGH 137
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
23-191 |
5.00e-05 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 43.81 E-value: 5.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 23 SPTPIQQQAIPAVLGGGD------LLAGAqTGTGKTagFT-LPILQRLHTFYaehrgakRAVRALILTPTRELAAQvees 95
Cdd:pfam04851 3 ELRPYQIEAIENLLESIKngqkrgLIVMA-TGSGKT--LTaAKLIARLFKKG-------PIKKVLFLVPRKDLLEQ---- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 96 vrAYSKYLKLRSTVMFGGVSINPQ-IDALKRGVDIVVATPGRLLDHMQQKTIDLSDL--DILVLDEADRMLDMGFihdiK 172
Cdd:pfam04851 69 --ALEEFKKFLPNYVEIGEIISGDkKDESVDDNKIVVTTIQSLYKALELASLELLPDffDVIIIDEAHRSGASSY----R 142
|
170
....*....|....*....
gi 736058015 173 RVLAKLPPQRQnLLFSATF 191
Cdd:pfam04851 143 NILEYFKPAFL-LGLTATP 160
|
|
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
26-214 |
6.86e-05 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 45.32 E-value: 6.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 26 PIQQQAIPAVLGGGDLLAGAQTGTGKTagftlpilqrLHTFYAEHRGAKRAVRALILTPTRELAAQveesvraysKYLKL 105
Cdd:COG4581 28 PFQEEAILALEAGRSVLVAAPTGSGKT----------LVAEFAIFLALARGRRSFYTAPIKALSNQ---------KFFDL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 106 RStvMFGG---------VSINPqiDAlkrgvDIVVATPGRLLDHMQQKTIDLSDLDILVLDEADrmldmgFIHDIKR--- 173
Cdd:COG4581 89 VE--RFGAenvglltgdASVNP--DA-----PIVVMTTEILRNMLYREGADLEDVGVVVMDEFH------YLADPDRgwv 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 736058015 174 ---VLAKLPPQRQNLLFSATFSD--EIKALADSLLDSPALIEVARR 214
Cdd:COG4581 154 weePIIHLPARVQLVLLSATVGNaeEFAEWLTRVRGETAVVVSEER 199
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
28-341 |
1.31e-04 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 44.49 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 28 QQQAIPAVLGGGDLLAGAQTGTGKTagftlpilqrLHTFYAEHRGAKRAVRALILTPTRELAAQveesvrAYSKYLKLRS 107
Cdd:PRK01172 27 QRMAIEQLRKGENVIVSVPTAAGKT----------LIAYSAIYETFLAGLKSIYIVPLRSLAME------KYEELSRLRS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 108 TVMFGGVSI---NPQIDALKRgVDIVVATPGRLLDHMQQKTIDLSDLDILVLDE------ADRMLDMGFIHDIKRVLAkl 178
Cdd:PRK01172 91 LGMRVKISIgdyDDPPDFIKR-YDVVILTSEKADSLIHHDPYIINDVGLIVADEihiigdEDRGPTLETVLSSARYVN-- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 179 pPQRQNLLFSATFSDeIKALADSLldSPALIEVARRNTTAES--VAQKIHPVDRDRKREL-LTHLIRE--HNWFQVLVFT 253
Cdd:PRK01172 168 -PDARILALSATVSN-ANELAQWL--NASLIKSNFRPVPLKLgiLYRKRLILDGYERSQVdINSLIKEtvNDGGQVLVFV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 254 RTKHGANRLAEQLTK-------------------DGISAMAIHG------NKSQSARTRALAEFKNSTLQVLVATDIAAR 308
Cdd:PRK01172 244 SSRKNAEDYAEMLIQhfpefndfkvssennnvydDSLNEMLPHGvafhhaGLSNEQRRFIEEMFRNRYIKVIVATPTLAA 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 736058015 309 GIDidqLPH--VVNFDLPNVPEDYV---------HRIGRTGRAG 341
Cdd:PRK01172 324 GVN---LPArlVIVRDITRYGNGGIrylsnmeikQMIGRAGRPG 364
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
23-162 |
1.55e-04 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 42.40 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 23 SPTPIQQQAIPAVLGG------GDLLAGAQTGTGKTAGFTLPIlqrlhtFYAEHRGAkravRALILTPTRELAAQVEESV 96
Cdd:cd17918 15 SLTKDQAQAIKDIEKDlhspepMDRLLSGDVGSGKTLVALGAA------LLAYKNGK----QVAILVPTEILAHQHYEEA 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736058015 97 RAYSKYLKLRSTVMFGGVSINPQIdalkrgvDIVVATPGRLldhmqQKTIDLSDLDILVLDEADRM 162
Cdd:cd17918 85 RKFLPFINVELVTGGTKAQILSGI-------SLLVGTHALL-----HLDVKFKNLDLVIVDEQHRF 138
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
26-195 |
3.20e-04 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 41.55 E-value: 3.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 26 PIQQQAIPA-VLGGGDLLAGAQTGTGKTAGFTLPILQRLhtfyAEHRgakravRALILTPTRELAAQVEESVRAYSKY-L 103
Cdd:cd18028 4 PPQAEAVRAgLLKGENLLISIPTASGKTLIAEMAMVNTL----LEGG------KALYLVPLRALASEKYEEFKKLEEIgL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 104 KLrstvmfgGVSI--NPQIDALKRGVDIVVATPGRLLDHMQQKTIDLSDLDILVLDEadrmldMGFIHDIKR------VL 175
Cdd:cd18028 74 KV-------GISTgdYDEDDEWLGDYDIIVATYEKFDSLLRHSPSWLRDVGVVVVDE------IHLISDEERgptlesIV 140
|
170 180
....*....|....*....|....*
gi 736058015 176 AK---LPPQRQNLLFSATFS--DEI 195
Cdd:cd18028 141 ARlrrLNPNTQIIGLSATIGnpDEL 165
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
40-313 |
3.55e-04 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 42.80 E-value: 3.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 40 DLLAGAQTGTGKTAGFTLPILQRLHTFYAEhrgakravRALILTPTRELA-AQVEESVRAYSKYLKLRSTVMFGGVSINP 118
Cdd:cd09639 1 LLVIEAPTGYGKTEAALLWALHSLKSQKAD--------RVIIALPTRATInAMYRRAKEAFGETGLYHSSILSSRIKEMG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 119 QIDALKR-------GVDIVVATPGRL--LDHMQ----------QKTIDLSDLDILVLDEADRMLD--MGFIhdikrvLAK 177
Cdd:cd09639 73 DSEEFEHlfplyihSNDTLFLDPITVctIDQVLksvfgefghyEFTLASIANSLLIFDEVHFYDEytLALI------LAV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 178 LPPQRQN----LLFSATFSDEIKALADSlldspalIEVARRNTTAESVAQKIHPVdrdRKREL--------LTHLIREHN 245
Cdd:cd09639 147 LEVLKDNdvpiLLMSATLPKFLKEYAEK-------IGYVEENEPLDLKPNERAPF---IKIESdkvgeissLERLLEFIK 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736058015 246 WF-QVLVFTRTKHGANRLAEQLTKDG--ISAMAIHGNKSQSARTRA----LAEFKNSTLQVLVATDIAARGIDID 313
Cdd:cd09639 217 KGgSVAIIVNTVDRAQEFYQQLKEKGpeEEIMLIHSRFTEKDRAKKeaelLLEFKKSEKFVIVATQVIEASLDIS 291
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
250-320 |
7.49e-04 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 39.08 E-value: 7.49e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 736058015 250 LVFTRTKHGANRLAEQLTKDGISAMAIHGNKSQSARTRA---LAEFKNSTLQVLVATDIAARGIDIdqlPHVVN 320
Cdd:cd18799 10 LIFCVSIEHAEFMAEAFNEAGIDAVALNSDYSDRERGDEaliLLFFGELKPPILVTVDLLTTGVDI---PEVDN 80
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
31-161 |
1.13e-03 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 40.11 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 31 AIPAVLGGGDLLAgAQTGTGKTagftlpilqRLHTFYAEHR----GAKRAVRALILTPTRELAAQVEESVRAYSKYLKLR 106
Cdd:cd17927 11 AQPALKGKNTIIC-LPTGSGKT---------FVAVLICEHHlkkfPAGRKGKVVFLANKVPLVEQQKEVFRKHFERPGYK 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 736058015 107 STVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTI-DLSDLDILVLDEADR 161
Cdd:cd17927 81 VTGLSGDTSENVSVEQIVESSDVIIVTPQILVNDLKSGTIvSLSDFSLLVFDECHN 136
|
|
| cas3_core |
TIGR01587 |
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an ... |
40-313 |
1.15e-03 |
|
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.
Pssm-ID: 273707 [Multi-domain] Cd Length: 359 Bit Score: 41.29 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 40 DLLAGAQTGTGKT-AGFTlpilqrlhtfYAEHRGAKR-AVRALILTPTRELAAQVEESVRAY--SKYLKLRSTVMFGGVS 115
Cdd:TIGR01587 1 LLVIEAPTGYGKTeAALL----------WALHSIKSQkADRVIIALPTRATINAMYRRAKELfgSELVGLHHSSSFSRIK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 116 INPQIDALKR-------GVDIVVATPGRL--LDHMQ----------QKTIDLSDLDILVLDEADRMLD--MGFIhdikrv 174
Cdd:TIGR01587 71 EMGDSEEFEHlfplyihSNDKLFLDPITVctIDQVLksvfgefghyEFTLASIANSLLIFDEVHFYDEytLALI------ 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 175 LAKLPPQRQN----LLFSATFSDEIKALADSLL-----DSPALIEVARrnttaeSVAQKIHPVDRDRKREL--LTHLIRE 243
Cdd:TIGR01587 145 LAVLEVLKDNdvpiLLMSATLPKFLKEYAEKIGyvefnEPLDLKEERR------FENHRFILIESDKVGEIssLERLLEF 218
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 736058015 244 HNWF-QVLVFTRTKHGANRLAEQLTKDG--ISAMAIHGNKSQSAR----TRALAEFKNSTLQ-VLVATDIAARGIDID 313
Cdd:TIGR01587 219 IKKGgSIAIIVNTVDRAQEFYQQLKEKApeEEIILYHSRFTEKDRakkeAELLREMKKSNEKfVIVATQVIEASLDIS 296
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
45-163 |
1.92e-03 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 39.23 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 45 AQTGTGKTagfTLPILQRLHTfyaehrgAKRAVRALILTPTRELAAQVEESVRAYSKYL--KLRSTVMFGGVSINPQIDA 122
Cdd:cd17924 39 APTGVGKT---TFGLATSLYL-------ASKGKRSYLIFPTKSLVKQAYERLSKYAEKAgvEVKILVYHSRLKKKEKEEL 108
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 736058015 123 LKR----GVDIVVATPGRLLDHMQQktIDLSDLDILVLDEADRML 163
Cdd:cd17924 109 LEKiekgDFDILVTTNQFLSKNFDL--LSNKKFDFVFVDDVDAVL 151
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
19-190 |
4.83e-03 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 38.39 E-value: 4.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 19 LGYTSPTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILqrlhtFYAEHRGAKravrALILTPTRELAAQVEESVRA 98
Cdd:cd18018 8 FGHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPAL-----LLRRRGPGL----TLVVSPLIALMKDQVDALPR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 99 YSKYLKLRSTVMFGGVSINpqIDALKRG-VDIVVATPGRLLD----HMQQKTIDLSdldILVLDEADRMLDMG--FIHD- 170
Cdd:cd18018 79 AIKAAALNSSLTREERRRI--LEKLRAGeVKILYVSPERLVNesfrELLRQTPPIS---LLVVDEAHCISEWShnFRPDy 153
|
170 180
....*....|....*....|..
gi 736058015 171 --IKRVLAKLPPQRQNLLFSAT 190
Cdd:cd18018 154 lrLCRVLRELLGAPPVLALTAT 175
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
24-158 |
6.72e-03 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 37.84 E-value: 6.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 24 PTPIQQQAIPAVLGGGDLLAGAQTGTGKTAGFTLPILQRLHTFYAEHRGAKRAVraliLTPTRELaaqVEESVRAYSKYL 103
Cdd:cd18036 3 LRNYQLELVLPALRGKNTIICAPTGSGKTRVAVYICRHHLEKRRSAGEKGRVVV----LVNKVPL---VEQQLEKFFKYF 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 736058015 104 K--LRSTVMFGGVSINPQIDALKRGVDIVVATPGRLLDHMQQKTID----LSDLDILVLDE 158
Cdd:cd18036 76 RkgYKVTGLSGDSSHKVSFGQIVKASDVIICTPQILINNLLSGREEervyLSDFSLLIFDE 136
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
47-191 |
6.95e-03 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 36.90 E-value: 6.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 47 TGTGKTA-GFTLPIlqrlhtfyaehrgAKRAVRALILTPTRELAAQVEEsvraysKYLKLRSTVMFGGVSINPQIDalKR 125
Cdd:cd17926 27 TGSGKTLtALALIA-------------YLKELRTLIVVPTDALLDQWKE------RFEDFLGDSSIGLIGGGKKKD--FD 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736058015 126 GVDIVVATPgRLLDHMQQKTIDLSDL-DILVLDEADRMLDMGFIHDIKRVLAKLppqrqNLLFSATF 191
Cdd:cd17926 86 DANVVVATY-QSLSNLAEEEKDLFDQfGLLIVDEAHHLPAKTFSEILKELNAKY-----RLGLTATP 146
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
45-170 |
9.99e-03 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 36.76 E-value: 9.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736058015 45 AQTGTGKTagftlpilQRLHTFYAEhRGAKRAVRALILTPTRELAAQVEESVRayskylklrstvmfgGVSINPQIDALK 124
Cdd:cd17931 8 LHPGAGKT--------TRVLPQIIR-EAIKKRLRTLVLAPTRVVAAEMYEALR---------------GLPIRYRTGAVK 63
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 736058015 125 R---GVDIV-VATPGRLLDHMQQKtIDLSDLDILVLDEA-----DRMLDMGFIHD 170
Cdd:cd17931 64 EehgGNEIVdYMCHGTFTCRLLSP-KRVPNYNLIIMDEAhftdpASIAARGYIHT 117
|
|
| |
