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Conserved domains on  [gi|737122501|ref|WP_035110189|]
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MATE family efflux transporter [Clostridium tetani]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MATE_like super family cl09326
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 2-67 1.38e-10

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


The actual alignment was detected with superfamily member cd13143:

Pssm-ID: 447704 [Multi-domain]  Cd Length: 426  Bit Score: 55.21  E-value: 1.38e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 737122501   2 FSVAMMQLMYLIQQTALYTIISIYGGDEKVVLMRVALRILMFTFIPTCGIGQGLQPIVGMNFGAKD 67
Cdd:cd13143  233 FPSFLMQLSSSVVTIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGN 298
 
Name Accession Description Interval E-value
MATE_MepA_like cd13143
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 2-67 1.38e-10

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.


Pssm-ID: 240548 [Multi-domain]  Cd Length: 426  Bit Score: 55.21  E-value: 1.38e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 737122501   2 FSVAMMQLMYLIQQTALYTIISIYGGDEKVVLMRVALRILMFTFIPTCGIGQGLQPIVGMNFGAKD 67
Cdd:cd13143  233 FPSFLMQLSSSVVTIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGN 298
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
2-67 3.01e-07

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 45.52  E-value: 3.01e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 737122501   2 FSVAMMQLMYLIQQTALYTIISIYGgDEKVVLMRVALRILMFTFIPTCGIGQGLQPIVGMNFGAKD 67
Cdd:COG0534  236 LPAGLQQLAESLGFLVLNALVARLG-TAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGD 300
 
Name Accession Description Interval E-value
MATE_MepA_like cd13143
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 2-67 1.38e-10

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.


Pssm-ID: 240548 [Multi-domain]  Cd Length: 426  Bit Score: 55.21  E-value: 1.38e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 737122501   2 FSVAMMQLMYLIQQTALYTIISIYGGDEKVVLMRVALRILMFTFIPTCGIGQGLQPIVGMNFGAKD 67
Cdd:cd13143  233 FPSFLMQLSSSVVTIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGN 298
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
2-67 3.01e-07

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 45.52  E-value: 3.01e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 737122501   2 FSVAMMQLMYLIQQTALYTIISIYGgDEKVVLMRVALRILMFTFIPTCGIGQGLQPIVGMNFGAKD 67
Cdd:COG0534  236 LPAGLQQLAESLGFLVLNALVARLG-TAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGD 300
MATE_MJ0709_like cd13147
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ...
 20-67 8.22e-05

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240552 [Multi-domain]  Cd Length: 441  Bit Score: 38.68  E-value: 8.22e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 737122501  20 TIISIYGGDEKVVLMRVALRILMFTFIPTCGIGQGLQPIVGMNFGAKD 67
Cdd:cd13147  255 LILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARN 302
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 2-67 2.71e-04

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 37.30  E-value: 2.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 737122501   2 FSVAMMQLMYLIQQTALYTIISIYGGDEKVVLMRVALRILMFTFIPTCGIGQGLQPIVGMNFGAKD 67
Cdd:cd12082  226 LPSAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGN 291
MATE_NorM_like cd13137
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 4-67 2.30e-03

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240542 [Multi-domain]  Cd Length: 432  Bit Score: 34.79  E-value: 2.30e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 737122501   4 VAMMQLMYLIQQTALYTIISIYGgDEKVVLMRVALRILMFTFIPTCGIGQGLQPIVGMNFGAKD 67
Cdd:cd13137  235 AGLEQLLRSLGFLVLLAIVASYG-TAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGD 297
MATE_like_2 cd13149
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 17-66 5.03e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240554 [Multi-domain]  Cd Length: 434  Bit Score: 33.82  E-value: 5.03e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 737122501  17 ALYTIISIYGGDEKVVLMRVALRILMFTFIPTCGIGQGLQPIVGMNFGAK 66
Cdd:cd13149  255 AFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAG 304
MATE_like_4 cd13144
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 2-68 5.49e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240549 [Multi-domain]  Cd Length: 434  Bit Score: 33.74  E-value: 5.49e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 737122501   2 FSVAMMQLMYLIQQTALYTIISIYGGDEKVVLMrVALRILMFTFIPTCGIGQGLQPIVGMNFGAKDS 68
Cdd:cd13144  240 LPSIIMQAISSVMVFGLNKILAGFGPTAVAVFG-IYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNK 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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