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Conserved domains on  [gi|737222144|ref|WP_035206809|]
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MULTISPECIES: lipopolysaccharide kinase InaA family protein [Agrobacterium]

Protein Classification

serine/threonine-protein kinase( domain architecture ID 10007648)

serine/threonine-protein kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bud32 COG3642
tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and ...
 88-247 2.89e-17

tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and biogenesis]; tRNA A-37 threonylcarbamoyl transferase component Bud32 is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 442859 [Multi-domain]  Cd Length: 159  Bit Score: 76.92  E-value: 2.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222144  88 MQRELETLQQFQQRGFPVPPLIY--SSRTAVVLGDV-GPTLMERMDALKASDpiehdALLVKSAEALGELHAAGLCHGRP 164
Cdd:COG3642    3 TRREARLLRELREAGVPVPKVLDvdPDDADLVMEYIeGETLADLLEEGELPP-----ELLRELGRLLARLHRAGIVHGDL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222144 165 HVRDFFLKDGRIGFMDFEERPQDvMPLEtAQARDIWLLFLQVATRAND-APKTRDAAFSRWLENAPPRALEELTRLTRIL 243
Cdd:COG3642   78 TTSNILVDDGGVYLIDFGLARYS-DPLE-DKAVDLAVLKRSLESTHPDpAEELWEAFLEGYREVGPAEEVLRRLREIELR 155


                 ....
gi 737222144 244 GRFL 247
Cdd:COG3642  156 GRYL 159
 
Name Accession Description Interval E-value
Bud32 COG3642
tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and ...
 88-247 2.89e-17

tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and biogenesis]; tRNA A-37 threonylcarbamoyl transferase component Bud32 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442859 [Multi-domain]  Cd Length: 159  Bit Score: 76.92  E-value: 2.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222144  88 MQRELETLQQFQQRGFPVPPLIY--SSRTAVVLGDV-GPTLMERMDALKASDpiehdALLVKSAEALGELHAAGLCHGRP 164
Cdd:COG3642    3 TRREARLLRELREAGVPVPKVLDvdPDDADLVMEYIeGETLADLLEEGELPP-----ELLRELGRLLARLHRAGIVHGDL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222144 165 HVRDFFLKDGRIGFMDFEERPQDvMPLEtAQARDIWLLFLQVATRAND-APKTRDAAFSRWLENAPPRALEELTRLTRIL 243
Cdd:COG3642   78 TTSNILVDDGGVYLIDFGLARYS-DPLE-DKAVDLAVLKRSLESTHPDpAEELWEAFLEGYREVGPAEEVLRRLREIELR 155


                 ....
gi 737222144 244 GRFL 247
Cdd:COG3642  156 GRYL 159
Kdo pfam06293
Lipopolysaccharide kinase (Kdo/WaaP) family; These lipopolysaccharide kinases are related to ...
 90-182 1.13e-04

Lipopolysaccharide kinase (Kdo/WaaP) family; These lipopolysaccharide kinases are related to protein kinases pfam00069. This family includes waaP (rfaP) gene product is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that WaaP is necessary for resistance to hydrophobic and polycationic antimicrobials in E. coli and that it is required for virulence in invasive strains of S. enterica.


Pssm-ID: 428872  Cd Length: 206  Bit Score: 42.38  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222144   90 RELETLQQFQQRGFPVPPLIYSSRTAVVLGDVGPTLMERMD--------ALKASDPIE--HDALLVKSAEALGELHAAGL 159
Cdd:pfam06293  59 REFRLIRRLREAGLPVPKPVAAGEVKVGGGYRADLLTERLEgaqsladwLADWAVPSGelRRAIWEAVGRLIRQMHRAGV 138

                          90       100
                  ....*....|....*....|....*...
gi 737222144  160 CHGRPHVRDFFLKDG-----RIGFMDFE 182
Cdd:pfam06293 139 QHGDLYAHHILLQQEgdegfEAWLIDLD 166
PRK09605 PRK09605
bifunctional N(6)-L-threonylcarbamoyladenine synthase/serine/threonine protein kinase;
101-181 1.17e-04

bifunctional N(6)-L-threonylcarbamoyladenine synthase/serine/threonine protein kinase;


Pssm-ID: 236586 [Multi-domain]  Cd Length: 535  Bit Score: 43.34  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222144 101 RGFPVP-PLIYssrtavvlgDVGPT----LMERMDALKASDPIEHDALLVKS-AEALGELHAAGLCHGRPHVRDFFLKDG 174
Cdd:PRK09605 394 RRAGVPtPVIY---------DVDPEektiVMEYIGGKDLKDVLEGNPELVRKvGEIVAKLHKAGIVHGDLTTSNFIVRDD 464


                 ....*..
gi 737222144 175 RIGFMDF 181
Cdd:PRK09605 465 RLYLIDF 471
arch_bud32 TIGR03724
Kae1-associated kinase Bud32; Members of this protein family are the Bud32 protein associated ...
 126-181 1.10e-03

Kae1-associated kinase Bud32; Members of this protein family are the Bud32 protein associated with Kae1 (kinase-associated endopeptidase 1) in the Archaea. In many Archaeal genomes, Kae1 and Bud32 are fused. The complex is homologous to the Kae1 and Bud32 subunits of the eukaryotic KEOPS complex, an apparently ancient protein kinase-containing molecular machine. [Unknown function, General]


Pssm-ID: 274749 [Multi-domain]  Cd Length: 199  Bit Score: 39.12  E-value: 1.10e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 737222144  126 MERMDALKASDPIE--HDALLVKSAEALGELHAAGLCHGRPHVRDFFLKDGRIGFMDF 181
Cdd:TIGR03724  76 MEYIEGKPLKDVIEenGDELAREIGRLVGKLHKAGIVHGDLTTSNIIVRDDKVYLIDF 133
 
Name Accession Description Interval E-value
Bud32 COG3642
tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and ...
 88-247 2.89e-17

tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and biogenesis]; tRNA A-37 threonylcarbamoyl transferase component Bud32 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442859 [Multi-domain]  Cd Length: 159  Bit Score: 76.92  E-value: 2.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222144  88 MQRELETLQQFQQRGFPVPPLIY--SSRTAVVLGDV-GPTLMERMDALKASDpiehdALLVKSAEALGELHAAGLCHGRP 164
Cdd:COG3642    3 TRREARLLRELREAGVPVPKVLDvdPDDADLVMEYIeGETLADLLEEGELPP-----ELLRELGRLLARLHRAGIVHGDL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222144 165 HVRDFFLKDGRIGFMDFEERPQDvMPLEtAQARDIWLLFLQVATRAND-APKTRDAAFSRWLENAPPRALEELTRLTRIL 243
Cdd:COG3642   78 TTSNILVDDGGVYLIDFGLARYS-DPLE-DKAVDLAVLKRSLESTHPDpAEELWEAFLEGYREVGPAEEVLRRLREIELR 155


                 ....
gi 737222144 244 GRFL 247
Cdd:COG3642  156 GRYL 159
Kdo pfam06293
Lipopolysaccharide kinase (Kdo/WaaP) family; These lipopolysaccharide kinases are related to ...
 90-182 1.13e-04

Lipopolysaccharide kinase (Kdo/WaaP) family; These lipopolysaccharide kinases are related to protein kinases pfam00069. This family includes waaP (rfaP) gene product is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that WaaP is necessary for resistance to hydrophobic and polycationic antimicrobials in E. coli and that it is required for virulence in invasive strains of S. enterica.


Pssm-ID: 428872  Cd Length: 206  Bit Score: 42.38  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222144   90 RELETLQQFQQRGFPVPPLIYSSRTAVVLGDVGPTLMERMD--------ALKASDPIE--HDALLVKSAEALGELHAAGL 159
Cdd:pfam06293  59 REFRLIRRLREAGLPVPKPVAAGEVKVGGGYRADLLTERLEgaqsladwLADWAVPSGelRRAIWEAVGRLIRQMHRAGV 138

                          90       100
                  ....*....|....*....|....*...
gi 737222144  160 CHGRPHVRDFFLKDG-----RIGFMDFE 182
Cdd:pfam06293 139 QHGDLYAHHILLQQEgdegfEAWLIDLD 166
PRK09605 PRK09605
bifunctional N(6)-L-threonylcarbamoyladenine synthase/serine/threonine protein kinase;
101-181 1.17e-04

bifunctional N(6)-L-threonylcarbamoyladenine synthase/serine/threonine protein kinase;


Pssm-ID: 236586 [Multi-domain]  Cd Length: 535  Bit Score: 43.34  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222144 101 RGFPVP-PLIYssrtavvlgDVGPT----LMERMDALKASDPIEHDALLVKS-AEALGELHAAGLCHGRPHVRDFFLKDG 174
Cdd:PRK09605 394 RRAGVPtPVIY---------DVDPEektiVMEYIGGKDLKDVLEGNPELVRKvGEIVAKLHKAGIVHGDLTTSNFIVRDD 464


                 ....*..
gi 737222144 175 RIGFMDF 181
Cdd:PRK09605 465 RLYLIDF 471
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 77-164 3.87e-04

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 41.25  E-value: 3.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222144  77 RPSEPLDGAGLMQRELETLQQFQQR-GFPVPPLIYSSRTAVVLGDVGpTLMERM------DALKASDPIEHDALLVKSAE 149
Cdd:COG3173   49 RPPRGLASAHDVRREARVLRALAPRlGVPVPRPLALGEDGEVIGAPF-YVMEWVegetleDALPDLSPAERRALARALGE 127

                         90       100
                 ....*....|....*....|
gi 737222144 150 ALGELH-----AAGLCHGRP 164
Cdd:COG3173  128 FLAALHavdpaAAGLADGRP 147
arch_bud32 TIGR03724
Kae1-associated kinase Bud32; Members of this protein family are the Bud32 protein associated ...
 126-181 1.10e-03

Kae1-associated kinase Bud32; Members of this protein family are the Bud32 protein associated with Kae1 (kinase-associated endopeptidase 1) in the Archaea. In many Archaeal genomes, Kae1 and Bud32 are fused. The complex is homologous to the Kae1 and Bud32 subunits of the eukaryotic KEOPS complex, an apparently ancient protein kinase-containing molecular machine. [Unknown function, General]


Pssm-ID: 274749 [Multi-domain]  Cd Length: 199  Bit Score: 39.12  E-value: 1.10e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 737222144  126 MERMDALKASDPIE--HDALLVKSAEALGELHAAGLCHGRPHVRDFFLKDGRIGFMDF 181
Cdd:TIGR03724  76 MEYIEGKPLKDVIEenGDELAREIGRLVGKLHKAGIVHGDLTTSNIIVRDDKVYLIDF 133
PRK14879 PRK14879
Kae1-associated kinase Bud32;
90-203 2.09e-03

Kae1-associated kinase Bud32;


Pssm-ID: 237847 [Multi-domain]  Cd Length: 211  Bit Score: 38.73  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222144  90 RELETLQQFQQRGFPVPpliyssrtAVVLGDVGPTL--MERMDALKASDPIEH-DALLVKSAEALGE----LHAAGLCHG 162
Cdd:PRK14879  48 REARIMSRARKAGVNVP--------AVYFVDPENFIivMEYIEGEPLKDLINSnGMEELELSREIGRlvgkLHSAGIIHG 119

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 737222144 163 RPHVRDFFLKDGRIGFMDF--EERPQDVmpleTAQARDIWLLF 203
Cdd:PRK14879 120 DLTTSNMILSGGKIYLIDFglAEFSKDL----EDRAVDLHVLL 158
RIO2 COG0478
RIO-like serine/threonine protein kinase fused to N-terminal HTH domain [Signal transduction ...
 89-162 4.55e-03

RIO-like serine/threonine protein kinase fused to N-terminal HTH domain [Signal transduction mechanisms];


Pssm-ID: 440246 [Multi-domain]  Cd Length: 183  Bit Score: 37.19  E-value: 4.55e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 737222144  89 QRELETLQQFQQRGFPVPPLIYSSRTAVVlgdvgptlMERMDA-----LKASDPiehDALLVKSAEALGELHAAGLCHG 162
Cdd:COG0478   47 EREFRALERLYPAGLPVPRPIAANRHAIV--------MERIEGvelarLKLEDP---EEVLDKILEEIRRAHDAGIVHA 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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