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Conserved domains on  [gi|740314785|ref|WP_038152099|]
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MULTISPECIES: GNAT family N-acetyltransferase [Vibrio]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10008168)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl coenzyme A to a substrate

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  9175471|10940244|15581578
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3981 COG3981
Predicted acetyltransferase [General function prediction only];
1-171 8.91e-68

Predicted acetyltransferase [General function prediction only];


:

Pssm-ID: 443180  Cd Length: 170  Bit Score: 203.99  E-value: 8.91e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740314785   1 MKLVAPHPCYESAFHIFYQDFvHHDPENSAYYEPSQHAFAQYVQRLNDEAQGIGLPTGYVPCNHFWLVDDAHQILGAIRV 80
Cdd:COG3981    2 MELVRPTLEDEESYLEYLAEF-LKEHIDGSGYLVSFEDFEAWLERLLDEEKGEELPEGWVPATTYWLVDEDGRIVGAINL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740314785  81 RHHIeNDFLRVECGHIGYDVAPSQRRQGVGSHMLSLALRQAHALGIERALLVADSDNWASRGVIENNGGVFESLVWGKVF 160
Cdd:COG3981   81 RHEL-NEFLLRVGGHIGYGVRPSERGKGYATEMLRLALEEARELGLDRVLITCDKDNIASRKVIEANGGVLEDEVVDEED 159

                        170
                 ....*....|.
gi 740314785 161 ECELARYWIET 171
Cdd:COG3981  160 GRPVRRYWIDL 170
 
Name Accession Description Interval E-value
COG3981 COG3981
Predicted acetyltransferase [General function prediction only];
1-171 8.91e-68

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443180  Cd Length: 170  Bit Score: 203.99  E-value: 8.91e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740314785   1 MKLVAPHPCYESAFHIFYQDFvHHDPENSAYYEPSQHAFAQYVQRLNDEAQGIGLPTGYVPCNHFWLVDDAHQILGAIRV 80
Cdd:COG3981    2 MELVRPTLEDEESYLEYLAEF-LKEHIDGSGYLVSFEDFEAWLERLLDEEKGEELPEGWVPATTYWLVDEDGRIVGAINL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740314785  81 RHHIeNDFLRVECGHIGYDVAPSQRRQGVGSHMLSLALRQAHALGIERALLVADSDNWASRGVIENNGGVFESLVWGKVF 160
Cdd:COG3981   81 RHEL-NEFLLRVGGHIGYGVRPSERGKGYATEMLRLALEEARELGLDRVLITCDKDNIASRKVIEANGGVLEDEVVDEED 159

                        170
                 ....*....|.
gi 740314785 161 ECELARYWIET 171
Cdd:COG3981  160 GRPVRRYWIDL 170
Acetyltransf_3 pfam13302
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 25-148 1.13e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 379112 [Multi-domain]  Cd Length: 139  Bit Score: 53.89  E-value: 1.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740314785   25 DPENSAYYEPSQHAFAQYVQRLNDEAQGIGLPTGYVpcnhfWLVDDAHQ-ILGAIRVRHHIENDflrvECGHIGYDVAPS 103
Cdd:pfam13302  21 DPEVMRYGVPWPLTLEEAREWLARIWAADEAERGYG-----WAIELKDTgFIGSIGLYDIDGEP----ERAELGYWLGPD 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 740314785  104 QRRQGVGSHMLSLALRQA-HALGIERALLVADSDNWASRGVIENNG 148
Cdd:pfam13302  92 YWGKGYATEAVRALLEYAfEELGLPRLVARIDPENTASRRVLEKLG 137
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 65-131 3.32e-07

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 45.34  E-value: 3.32e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 740314785  65 FWLVDDAHQILGAIRVRHHiENDFLRVECGHIGydVAPSQRRQGVGSHMLSLALRQAHALGIERALL 131
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPD-GSGGDTAYIGDLA--VLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
 
Name Accession Description Interval E-value
COG3981 COG3981
Predicted acetyltransferase [General function prediction only];
1-171 8.91e-68

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443180  Cd Length: 170  Bit Score: 203.99  E-value: 8.91e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740314785   1 MKLVAPHPCYESAFHIFYQDFvHHDPENSAYYEPSQHAFAQYVQRLNDEAQGIGLPTGYVPCNHFWLVDDAHQILGAIRV 80
Cdd:COG3981    2 MELVRPTLEDEESYLEYLAEF-LKEHIDGSGYLVSFEDFEAWLERLLDEEKGEELPEGWVPATTYWLVDEDGRIVGAINL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740314785  81 RHHIeNDFLRVECGHIGYDVAPSQRRQGVGSHMLSLALRQAHALGIERALLVADSDNWASRGVIENNGGVFESLVWGKVF 160
Cdd:COG3981   81 RHEL-NEFLLRVGGHIGYGVRPSERGKGYATEMLRLALEEARELGLDRVLITCDKDNIASRKVIEANGGVLEDEVVDEED 159

                        170
                 ....*....|.
gi 740314785 161 ECELARYWIET 171
Cdd:COG3981  160 GRPVRRYWIDL 170
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 23-152 9.76e-12

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 60.01  E-value: 9.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740314785  23 HHDPENSAYYEPSQHAFAQYVQRLNDEAQGIGLPTGYvpcnHFWLVDDA-HQILGAIRVrHHIENDFLRVEcghIGYDVA 101
Cdd:COG1670   25 LNDPEVARYLPGPPYSLEEARAWLERLLADWADGGAL----PFAIEDKEdGELIGVVGL-YDIDRANRSAE---IGYWLA 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 740314785 102 PSQRRQGVGSHMLSLALRQA-HALGIERALLVADSDNWASRGVIENNGGVFE 152
Cdd:COG1670   97 PAYWGKGYATEALRALLDYAfEELGLHRVEAEVDPDNTASIRVLEKLGFRLE 148
Acetyltransf_3 pfam13302
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 25-148 1.13e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 379112 [Multi-domain]  Cd Length: 139  Bit Score: 53.89  E-value: 1.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740314785   25 DPENSAYYEPSQHAFAQYVQRLNDEAQGIGLPTGYVpcnhfWLVDDAHQ-ILGAIRVRHHIENDflrvECGHIGYDVAPS 103
Cdd:pfam13302  21 DPEVMRYGVPWPLTLEEAREWLARIWAADEAERGYG-----WAIELKDTgFIGSIGLYDIDGEP----ERAELGYWLGPD 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 740314785  104 QRRQGVGSHMLSLALRQA-HALGIERALLVADSDNWASRGVIENNG 148
Cdd:pfam13302  92 YWGKGYATEAVRALLEYAfEELGLPRLVARIDPENTASRRVLEKLG 137
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
23-148 8.16e-08

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 49.22  E-value: 8.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740314785  23 HHDPENSAYYEPSQHAFAQYVQRLNDEAQgiglptgyvPCNHFWLVDDAHQILGAIRVRHHIENDFLRvecgHIGYD--- 99
Cdd:COG1247   21 EAIAEGTATFETEPPSEEEREAWFAAILA---------PGRPVLVAEEDGEVVGFASLGPFRPRPAYR----GTAEEsiy 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 740314785 100 VAPSQRRQGVGSHMLSLALRQAHALGIERALLVADSDNWASRGVIENNG 148
Cdd:COG1247   88 VDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLG 136
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
64-139 2.06e-07

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 47.77  E-value: 2.06e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 740314785  64 HFWLVDDAHQILGAIRV-RHHIENDFLRVECGHIGydVAPSQRRQGVGSHMLSLALRQAHALGIERALLVADSDNWA 139
Cdd:COG3153   40 LSLVAEDDGEIVGHVALsPVDIDGEGPALLLGPLA--VDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLP 114
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 65-131 3.32e-07

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 45.34  E-value: 3.32e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 740314785  65 FWLVDDAHQILGAIRVRHHiENDFLRVECGHIGydVAPSQRRQGVGSHMLSLALRQAHALGIERALL 131
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPD-GSGGDTAYIGDLA--VLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 59-136 8.31e-07

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 46.14  E-value: 8.31e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 740314785  59 YVPCNHFWLVDDAHQILGAIRVRHHIENDflrVECGHIGydVAPSQRRQGVGSHMLSLALRQAHALGIERALLVADSD 136
Cdd:COG1246   24 EEEIGEFWVAEEDGEIVGCAALHPLDEDL---AELRSLA--VHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSA 96
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 60-148 1.36e-06

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 45.20  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740314785   60 VPCNHFWLVDDAHQILGAIRVrhHIENDFLRveCGHI-GYDVAPSQRRQGVGSHMLSLALRQAHALGIERALLVADSDNW 138
Cdd:pfam00583  30 DASEGFFVAEEDGELVGFASL--SIIDDEPP--VGEIeGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNL 105

                          90
                  ....*....|
gi 740314785  139 ASRGVIENNG 148
Cdd:pfam00583 106 AAIALYEKLG 115
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 64-131 1.15e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 41.67  E-value: 1.15e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 740314785   64 HFWLVDDAHQILGAIRVRHHIENDFLrvecGHIGYDVAPSQRRQGVGSHMLSLALRQAHALGIERALL 131
Cdd:pfam13508   4 RFFVAEDDGKIVGFAALLPLDDEGAL----AELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLEL 67
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 100-148 1.51e-05

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 41.56  E-value: 1.51e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 740314785 100 VAPSQRRQGVGSHMLSLALRQAHALGIERALLVADSDNWASRGVIENNG 148
Cdd:COG0456   21 VDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLG 69
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 63-139 8.45e-05

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 40.33  E-value: 8.45e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 740314785   63 NHFWLVDDAHQILGAIRVRhhiendflrvECGHIG-YDVAPSQRRQGVGSHMLSLALRQAHALGIERALLVADSDNWA 139
Cdd:pfam13673  31 YFFFVAFEGGQIVGVIALR----------DRGHISlLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTVNASPYA 98
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
62-133 1.78e-04

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 39.40  E-value: 1.78e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 740314785  62 CNHFWLVDDaHQILGAIRVRHHIENDflrvecGHIGY-DVAPSQRRQGVGSHMLSLALRQAHALGIERALLVA 133
Cdd:COG2153   34 ARHLLAYDD-GELVATARLLPPGDGE------AKIGRvAVLPEYRGQGLGRALMEAAIEEARERGARRIVLSA 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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