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Conserved domains on  [gi|787738413|ref|WP_045757405|]
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HAMP domain-containing sensor histidine kinase [Xanthomonas albilineans]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

EC:  2.7.13.3
Gene Ontology:  GO:0004673|GO:0007165|GO:0005524|GO:0000160|GO:0016020|GO:0000155
PubMed:  11489844|18076326|10966457|11406410|12372152|8029829

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
113-422 2.16e-57

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 191.66  E-value: 2.16e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 113 RLYLVFMRAQVQRLIFWFGVVPVVLILVAVLLFAWLTWRASRRLLSPVIWLARHVSQWDPRYPVAAELAPENLPAEVQGE 192
Cdd:COG0642    9 VLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 193 SRQLALALHALAQRVTEHVAREHNFTRDASHELRTPLTVIRVATDIAMTDPDlpPRLNRSLQRIQRAGRDMEAVIDAFLI 272
Cdd:COG0642   89 LLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELD--EEQREYLETILRSADRLLRLINDLLD 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 273 LAR--EADVVPQSETFEVADVIEYEIENARELLSGKPVALSVRVLAPV-RLHAPPRVLHVVMSNLLRNACSYTDAG-RIE 348
Cdd:COG0642  167 LSRleAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIKYTPEGgTVT 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 787738413 349 VEVAED----RISIRDTGIGMSDDALQRAFEPFFRAESDRP-QGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCF 422
Cdd:COG0642  247 VSVRREgdrvRISVEDTGPGIPPEDLERIFEPFFRTDPSRRgGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
113-422 2.16e-57

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 191.66  E-value: 2.16e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 113 RLYLVFMRAQVQRLIFWFGVVPVVLILVAVLLFAWLTWRASRRLLSPVIWLARHVSQWDPRYPVAAELAPENLPAEVQGE 192
Cdd:COG0642    9 VLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 193 SRQLALALHALAQRVTEHVAREHNFTRDASHELRTPLTVIRVATDIAMTDPDlpPRLNRSLQRIQRAGRDMEAVIDAFLI 272
Cdd:COG0642   89 LLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELD--EEQREYLETILRSADRLLRLINDLLD 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 273 LAR--EADVVPQSETFEVADVIEYEIENARELLSGKPVALSVRVLAPV-RLHAPPRVLHVVMSNLLRNACSYTDAG-RIE 348
Cdd:COG0642  167 LSRleAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIKYTPEGgTVT 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 787738413 349 VEVAED----RISIRDTGIGMSDDALQRAFEPFFRAESDRP-QGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCF 422
Cdd:COG0642  247 VSVRREgdrvRISVEDTGPGIPPEDLERIFEPFFRTDPSRRgGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
phoR_proteo TIGR02966
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ...
 208-422 6.15e-30

phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]


Pssm-ID: 274368 [Multi-domain]  Cd Length: 333  Bit Score: 118.47  E-value: 6.15e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  208 TEHVAREhnFTRDASHELRTPLTVIR--VATDIAMTDPDlPPRLNRSLQRIQRAGRDMEAVIDAFLILAR-EADVVPQSE 284
Cdd:TIGR02966 110 LEQMRRD--FVANVSHELRTPLTVLRgyLETLADGPDED-PEEWNRALEIMLEQSQRMQSLVEDLLTLSRlESAASPLED 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  285 T-FEVADVIEYEIENARELLSGKPVALSVRVLAPVRLHAPPRVLHVVMSNLLRNACSYT-DAGRIEVEVAED----RISI 358
Cdd:TIGR02966 187 EpVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYTpEGGTITVRWRRDgggaEFSV 266

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 787738413  359 RDTGIGMSDDALQRAFEPFFRAESDRPQ---GTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCF 422
Cdd:TIGR02966 267 TDTGIGIAPEHLPRLTERFYRVDKSRSRdtgGTGLGLAIVKHVLSRHHARLEIESELGKGSTFSFIF 333
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 324-425 1.12e-27

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 105.81  E-value: 1.12e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413   324 PRVLHVVMSNLLRNACSYTDA-GRIEVEVAED----RISIRDTGIGMSDDALQRAFEPFFRAESDRPQ--GTGLGLSIVH 396
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEgGRITVTLERDgdhvEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKigGTGLGLSIVK 82

                           90       100
                   ....*....|....*....|....*....
gi 787738413   397 RLCDRFGWRVGLESAEGGGITATVCFDPA 425
Cdd:smart00387  83 KLVELHGGEISVESEPGGGTTFTITLPLE 111
PRK10337 PRK10337
sensor protein QseC; Provisional
 147-421 1.22e-27

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 113.98  E-value: 1.22e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 147 WLTWRAsrrlLSPVIWLARHVSQWDPRypVAAELAPENLPAEVqgesRQLALALHALAQRVTEHVAREHNFTRDASHELR 226
Cdd:PRK10337 180 VLLGRE----LAPLKKLALALRMRDPD--SETPLNATGVPSEV----RPLVEALNQLFARTHAMMVRERRFTSDAAHELR 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 227 TPLTVIRVATDIAMTDPDLPPRLNRSLQR----IQRAGRdmeaVIDAFLILAR---EADV-----VPQSETFEVADVIEY 294
Cdd:PRK10337 250 SPLAALKVQTEVAQLSDDDPQARKKALLQlhagIDRATR----LVDQLLTLSRldsLDNLqdvaeIPLEDLLQSAVMDIY 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 295 EIENArellSGKPVALSVRVlAPVRLHAPPRVLHVVMSNLLRNACSYTDAG-RIEVEVAEDRISIRDTGIGMSDDALQRA 373
Cdd:PRK10337 326 HTAQQ----AGIDVRLTLNA-HPVIRTGQPLLLSLLVRNLLDNAIRYSPQGsVVDVTLNARNFTVRDNGPGVTPEALARI 400

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 787738413 374 FEPFFRAESDRPQGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVC 421
Cdd:PRK10337 401 GERFYRPPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVS 448
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 324-426 1.61e-25

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 99.75  E-value: 1.61e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  324 PRVLHVVMSNLLRNACSYT-DAGRIEVEVAED---RISIRDTGIGMSDDALQRAFEPFFRAESDRPQGTGLGLSIVHRLC 399
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAaKAGEITVTLSEGgelTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGTGLGLSIVRKLV 82

                          90       100
                  ....*....|....*....|....*..
gi 787738413  400 DRFGWRVGLESAEGGGITATVCFDPAK 426
Cdd:pfam02518  83 ELLGGTITVESEPGGGTTVTLTLPLAQ 109
MtrAB_MtrB NF040691
MtrAB system histidine kinase MtrB;
217-394 7.50e-23

MtrAB system histidine kinase MtrB;


Pssm-ID: 468655 [Multi-domain]  Cd Length: 507  Bit Score: 100.48  E-value: 7.50e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 217 FTRDASHELRTPLTVIRVATD-IAMTDPDLPPRLNRSLQRIQRAGRDMEAVIDAFLILAR-EADVVP-QSETFEVADVIE 293
Cdd:NF040691 274 FVSDVSHELRTPLTTIRMAADvIHDSRDDFDPATARSAELLHTELDRFESLLSDLLEISRfDAGAAElDVEPVDLRPLVR 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 294 YEIENARELLSGKPVALSVRVLA-PVRLHAPPRVLHVVMSNLLRNACSYTDAGRIEVEVAEDR----ISIRDTGIGMSDD 368
Cdd:NF040691 354 RVVDALRQLAERAGVELRVDAPGtPVVAEVDPRRVERVLRNLVVNAIEHGEGKPVVVTVAQDDtavaVTVRDHGVGLKPG 433

                        170       180
                 ....*....|....*....|....*....
gi 787738413 369 ALQRAFEPFFRAESDRPQ---GTGLGLSI 394
Cdd:NF040691 434 EVALVFDRFWRADPARARttgGTGLGLAI 462
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 330-421 1.69e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 91.79  E-value: 1.69e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 330 VMSNLLRNACSYTDAGRIEVEVAED---------RISIRDTGIGMSDDALQRAFEPFFRAESD---RPQGTGLGLSIVHR 397
Cdd:cd16922    4 ILLNLLGNAIKFTEEGEVTLRVSLEeeeedgvqlRFSVEDTGIGIPEEQQARLFEPFSQADSSttrKYGGTGLGLAISKK 83

                         90       100
                 ....*....|....*....|....
gi 787738413 398 LCDRFGWRVGLESAEGGGITATVC 421
Cdd:cd16922   84 LVELMGGDISVESEPGQGSTFTFT 107
BaeS_SmeS NF012163
sensor histidine kinase efflux regulator BaeS;
217-422 1.07e-19

sensor histidine kinase efflux regulator BaeS;


Pssm-ID: 411086 [Multi-domain]  Cd Length: 457  Bit Score: 90.66  E-value: 1.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 217 FTRDASHELRTPLTVIRVATDiAMTDpDLPPRLNRSLQRIQRAGRDMEAVID--AFLILAREADVVPQSETFEVADVIEY 294
Cdd:NF012163 243 FMADISHELRTPLAVLRAELE-AIQD-GIRKFTPESLDSLQAEVGTLTKLVDdlHDLSMSDEGALAYQKASVDLVPLLEV 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 295 EIENARELLSGKPVALSVRVLAPVRLHAPPRVLHVVMSNLLRNACSYTDA-GRIEVEVAED----RISIRDTGIGMSDDA 369
Cdd:NF012163 321 EGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSgGSLHISASQRpkevTLTVADSAPGVSDEQ 400

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 787738413 370 LQRAFEPFFRAESDR---PQGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCF 422
Cdd:NF012163 401 LARLFERFYRVEVSRnraSGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTL 456
HK_WalK NF033092
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ...
 207-417 1.75e-16

cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.


Pssm-ID: 467964 [Multi-domain]  Cd Length: 594  Bit Score: 81.34  E-value: 1.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 207 VTEH--VAREH-NFTRDASHELRTPLTVIR----VATDIAMTDPDLPPRLnrsLQRIQRAGRDMEAVIDAFLILAR--EA 277
Cdd:NF033092 362 VTEQekIEQERrEFVANVSHELRTPLTTMRsyleALADGAWKDPELAPRF---LGVTQNETERMIRLVNDLLQLSRmdSK 438

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 278 DVVPQSETFEVADVIEYEIENARELLSGKPVALSVRVlapvrlhaPPRVLHV---------VMSNLLRNACSYT-DAGRI 347
Cdd:NF033092 439 DYKLNKEWVNFNEFFNYIIDRFEMILKNKNITFKREF--------PKRDLWVeidtdkitqVLDNIISNAIKYSpEGGTI 510

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 787738413 348 EVEVAEDR----ISIRDTGIGMSDDALQRAFEPFFR---AESdRPQ-GTGLGLSIVHRLCDRFGWRVGLESAEGGGIT 417
Cdd:NF033092 511 TFRLLETHnriiISISDQGLGIPKKDLDKIFDRFYRvdkARS-RKMgGTGLGLAIAKEVVEAHGGRIWAESEEGKGTT 587
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 221-420 1.89e-04

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 43.27  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 221 ASHELRTPLTVIR-VATDIAMTDPDLPP-----RLNRS--------LQRIQRAGRDMEAVIDaflilareadvvpqseTF 286
Cdd:NF033792 209 AAHELGTPLATIAlVAKELERELPDDPPlredaELLRSqaercrdiLRRLTSLGEEGDAHLD----------------RL 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 287 EVADVIEYEIENARELlsGKPVALSVrvlAPVRLHAP-----PRVLHvVMSNLLRNACSY-TDAGRIEVEVAEDRIS--I 358
Cdd:NF033792 273 PLSALIEEAAAPHRGF--GKEIEVVV---AGDPGEEPvirrnPEILY-GLGNLIENAVDFaRSTVTVTASWDAESVTitI 346

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 787738413 359 RDTGIGMSDDALQRAFEPFF---RAESDRP--QGTGLGLSIVHRLCDRFGWRVGLE--SAEGGGITATV 420
Cdd:NF033792 347 EDDGPGFPPDVLSRIGEPYVttrRGEERRPggGGLGLGLFIAKTLLERSGATVTFAnrPPPEGGAVVTV 415
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
113-422 2.16e-57

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 191.66  E-value: 2.16e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 113 RLYLVFMRAQVQRLIFWFGVVPVVLILVAVLLFAWLTWRASRRLLSPVIWLARHVSQWDPRYPVAAELAPENLPAEVQGE 192
Cdd:COG0642    9 VLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 193 SRQLALALHALAQRVTEHVAREHNFTRDASHELRTPLTVIRVATDIAMTDPDlpPRLNRSLQRIQRAGRDMEAVIDAFLI 272
Cdd:COG0642   89 LLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELD--EEQREYLETILRSADRLLRLINDLLD 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 273 LAR--EADVVPQSETFEVADVIEYEIENARELLSGKPVALSVRVLAPV-RLHAPPRVLHVVMSNLLRNACSYTDAG-RIE 348
Cdd:COG0642  167 LSRleAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIKYTPEGgTVT 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 787738413 349 VEVAED----RISIRDTGIGMSDDALQRAFEPFFRAESDRP-QGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCF 422
Cdd:COG0642  247 VSVRREgdrvRISVEDTGPGIPPEDLERIFEPFFRTDPSRRgGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
216-422 7.63e-53

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 176.64  E-value: 7.63e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 216 NFTRDASHELRTPLTVIRVATDIAMTDPDL-PPRLNRSLQRIQRAGRDMEAVIDAFLILAR--EADVVPQSETFEVADVI 292
Cdd:COG2205   18 EFLANVSHELRTPLTSILGAAELLLDEEDLsPEERRELLEIIRESAERLLRLIEDLLDLSRleSGKLSLELEPVDLAELL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 293 EYEIENARELLSGKPVALSVRV-LAPVRLHAPPRVLHVVMSNLLRNACSYTDAG-RIEVEVAED----RISIRDTGIGMS 366
Cdd:COG2205   98 EEAVEELRPLAEEKGIRLELDLpPELPLVYADPELLEQVLANLLDNAIKYSPPGgTITISARREgdgvRISVSDNGPGIP 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 787738413 367 DDALQRAFEPFFRAESDR-PQGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCF 422
Cdd:COG2205  178 EEELERIFERFYRGDNSRgEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
103-422 7.23e-51

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 176.28  E-value: 7.23e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 103 IVLVDQTPAGRLYLVFMRAQVQRLIFWFGVVPVVLILVAVLLFAWLTWRASRRLLSPVIWLARHVSQWDPRYPVAAELAP 182
Cdd:COG5002   51 LLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLL 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 183 ENLPAEVQGESRQLALALHALAQRVTEHVAREH---NFTRDASHELRTPLTVIRVATDIAMTDP-DLPPRLNRSLQRIQR 258
Cdd:COG5002  131 LGRLSLRLSALLLGLLLLAAVERDITELERLEQmrrEFVANVSHELRTPLTSIRGYLELLLDGAaDDPEERREYLEIILE 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 259 AGRDMEAVIDAFLILAR--EADVVPQSETFEVADVIEYEIENARELLSGKPVALSVRVLA-PVRLHAPPRVLHVVMSNLL 335
Cdd:COG5002  211 EAERLSRLVNDLLDLSRleSGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEdPLLVLGDPDRLEQVLTNLL 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 336 RNACSYTDAG-RIEVEVAED----RISIRDTGIGMSDDALQRAFEPFFRAESDR---PQGTGLGLSIVHRLCDRFGWRVG 407
Cdd:COG5002  291 DNAIKYTPEGgTITVSLREEddqvRISVRDTGIGIPEEDLPRIFERFYRVDKSRsreTGGTGLGLAIVKHIVEAHGGRIW 370

                        330
                 ....*....|....*
gi 787738413 408 LESAEGGGITATVCF 422
Cdd:COG5002  371 VESEPGKGTTFTITL 385
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 222-422 4.15e-36

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 137.02  E-value: 4.15e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 222 SHELRTPLTVI-----RVATDIAMTDPDLPPRLNRSLQRIQRAGRDMEAVIDAFLILAREADvvPQSETFEVADVIEYEI 296
Cdd:COG5000  209 AHEIKNPLTPIqlsaeRLRRKLADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPE--PQLEPVDLNELLREVL 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 297 ENARELLSGKPVALSVRVLAPV-RLHAPPRVLHVVMSNLLRNAC-SYTDAGRIEVEVAED----RISIRDTGIGMSDDAL 370
Cdd:COG5000  287 ALYEPALKEKDIRLELDLDPDLpEVLADRDQLEQVLINLLKNAIeAIEEGGEIEVSTRREdgrvRIEVSDNGPGIPEEVL 366

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 787738413 371 QRAFEPFFraeSDRPQGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCF 422
Cdd:COG5000  367 ERIFEPFF---TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 217-422 4.36e-32

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 127.21  E-value: 4.36e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 217 FTRDASHELRTPLTVIRVATDIAMTD--PDLPPRLNRSLQRIQRAGRDMEAVIDAFLILAREADVVPQSETFEVADVIEY 294
Cdd:COG4251  285 FAYVASHDLREPLRKISGFSQLLEEDygDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEFEPVDLNELLEE 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 295 EIENARELLSGKPVALSVRVLAPVRlhAPPRVLHVVMSNLLRNACSYTDAG---RIEVEVAED----RISIRDTGIGMSD 367
Cdd:COG4251  365 VLEDLEPRIEERGAEIEVGPLPTVR--GDPTLLRQVFQNLISNAIKYSRPGeppRIEIGAEREggewVFSVRDNGIGIDP 442

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 787738413 368 DALQRAFEPFFRAES-DRPQGTGLGLSIVHRLCDRFGWRVGLESAEGGGitATVCF 422
Cdd:COG4251  443 EYAEKIFEIFQRLHSrDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEG--ATFYF 496
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 223-422 3.43e-31

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 122.60  E-value: 3.43e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 223 HELRTPLTVIRVATDIA---MTDPDLPPRLNRSLQRIQRAGRDMEAVIDAFLILAREADvvPQSETFEVADVIEYEIENA 299
Cdd:COG4191  151 HEINNPLAAILGNAELLrrrLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDE--EEREPVDLNELIDEALELL 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 300 RELLSGKPVALSVRV-LAPVRLHAPPRVLHVVMSNLLRNACsytDA------GRIEVEVAED----RISIRDTGIGMSDD 368
Cdd:COG4191  229 RPRLKARGIEVELDLpPDLPPVLGDPGQLEQVLLNLLINAI---DAmeegegGRITISTRREgdyvVISVRDNGPGIPPE 305

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 787738413 369 ALQRAFEPFFraeSDRP--QGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCF 422
Cdd:COG4191  306 VLERIFEPFF---TTKPvgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
phoR_proteo TIGR02966
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ...
 208-422 6.15e-30

phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]


Pssm-ID: 274368 [Multi-domain]  Cd Length: 333  Bit Score: 118.47  E-value: 6.15e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  208 TEHVAREhnFTRDASHELRTPLTVIR--VATDIAMTDPDlPPRLNRSLQRIQRAGRDMEAVIDAFLILAR-EADVVPQSE 284
Cdd:TIGR02966 110 LEQMRRD--FVANVSHELRTPLTVLRgyLETLADGPDED-PEEWNRALEIMLEQSQRMQSLVEDLLTLSRlESAASPLED 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  285 T-FEVADVIEYEIENARELLSGKPVALSVRVLAPVRLHAPPRVLHVVMSNLLRNACSYT-DAGRIEVEVAED----RISI 358
Cdd:TIGR02966 187 EpVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYTpEGGTITVRWRRDgggaEFSV 266

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 787738413  359 RDTGIGMSDDALQRAFEPFFRAESDRPQ---GTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCF 422
Cdd:TIGR02966 267 TDTGIGIAPEHLPRLTERFYRVDKSRSRdtgGTGLGLAIVKHVLSRHHARLEIESELGKGSTFSFIF 333
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 324-425 1.12e-27

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 105.81  E-value: 1.12e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413   324 PRVLHVVMSNLLRNACSYTDA-GRIEVEVAED----RISIRDTGIGMSDDALQRAFEPFFRAESDRPQ--GTGLGLSIVH 396
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEgGRITVTLERDgdhvEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKigGTGLGLSIVK 82

                           90       100
                   ....*....|....*....|....*....
gi 787738413   397 RLCDRFGWRVGLESAEGGGITATVCFDPA 425
Cdd:smart00387  83 KLVELHGGEISVESEPGGGTTFTITLPLE 111
PRK10337 PRK10337
sensor protein QseC; Provisional
 147-421 1.22e-27

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 113.98  E-value: 1.22e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 147 WLTWRAsrrlLSPVIWLARHVSQWDPRypVAAELAPENLPAEVqgesRQLALALHALAQRVTEHVAREHNFTRDASHELR 226
Cdd:PRK10337 180 VLLGRE----LAPLKKLALALRMRDPD--SETPLNATGVPSEV----RPLVEALNQLFARTHAMMVRERRFTSDAAHELR 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 227 TPLTVIRVATDIAMTDPDLPPRLNRSLQR----IQRAGRdmeaVIDAFLILAR---EADV-----VPQSETFEVADVIEY 294
Cdd:PRK10337 250 SPLAALKVQTEVAQLSDDDPQARKKALLQlhagIDRATR----LVDQLLTLSRldsLDNLqdvaeIPLEDLLQSAVMDIY 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 295 EIENArellSGKPVALSVRVlAPVRLHAPPRVLHVVMSNLLRNACSYTDAG-RIEVEVAEDRISIRDTGIGMSDDALQRA 373
Cdd:PRK10337 326 HTAQQ----AGIDVRLTLNA-HPVIRTGQPLLLSLLVRNLLDNAIRYSPQGsVVDVTLNARNFTVRDNGPGVTPEALARI 400

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 787738413 374 FEPFFRAESDRPQGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVC 421
Cdd:PRK10337 401 GERFYRPPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVS 448
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 324-426 1.61e-25

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 99.75  E-value: 1.61e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  324 PRVLHVVMSNLLRNACSYT-DAGRIEVEVAED---RISIRDTGIGMSDDALQRAFEPFFRAESDRPQGTGLGLSIVHRLC 399
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAaKAGEITVTLSEGgelTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGTGLGLSIVRKLV 82

                          90       100
                  ....*....|....*....|....*..
gi 787738413  400 DRFGWRVGLESAEGGGITATVCFDPAK 426
Cdd:pfam02518  83 ELLGGTITVESEPGGGTTVTLTLPLAQ 109
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 146-413 3.28e-23

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 101.31  E-value: 3.28e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  146 AWLTWRASRRLLSPVIWLARHVSQWDPRyPVAAELAPENLPAEVqgesRQLALALHALAQRVTEHVAREHNFTRDASHEL 225
Cdd:TIGR01386 178 ALLGWWITRLGLEPLRRLSAVAARISPE-SLDQRLDPSRAPAEL----RELAQSFNAMLGRLEDAFQRLSQFSADLAHEL 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  226 RTPLTVIRVATDIAM----TDPDLPPRLNRSLQRIQRagrdMEAVIDAFLILAR--EADVVPQSETFEVADvieyEIENA 299
Cdd:TIGR01386 253 RTPLTNLLGQTQVALsqprTGEEYREVLESNLEELER----LSRMVSDMLFLARadNGQLALERVRLDLAA----ELAKV 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  300 RELLSgkPVA----LSVRVLAPVRLHAPPRVLHVVMSNLLRNACSYT-DAGRIEVEVAED----RISIRDTGIGMSDDAL 370
Cdd:TIGR01386 325 AEYFE--PLAeergVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTpDGGTITVRIERRsdevRVSVSNPGPGIPPEHL 402

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 787738413  371 QRAFEPFFRAESDR---PQGTGLGLSIVHRLCDRFGWRVGLESAEG 413
Cdd:TIGR01386 403 SRLFDRFYRVDPARsnsGEGTGLGLAIVRSIMEAHGGRASAESPDG 448
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
223-422 6.45e-23

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 99.15  E-value: 6.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 223 HELRTPLTVIRVATDIAMTDPDlPPRLNRSLQRIQRAGRDMEAVIDAFLILAREADvvPQSETFEVADVIEyeieNAREL 302
Cdd:COG3852  144 HEIRNPLTGIRGAAQLLERELP-DDELREYTQLIIEEADRLNNLVDRLLSFSRPRP--PEREPVNLHEVLE----RVLEL 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 303 LS---GKPVALSVRV---LAPVRLHaPPRVLHVVMsNLLRNAC-SYTDAGRIEVEVAED--------------RISIRDT 361
Cdd:COG3852  217 LRaeaPKNIRIVRDYdpsLPEVLGD-PDQLIQVLL-NLVRNAAeAMPEGGTITIRTRVErqvtlgglrprlyvRIEVIDN 294

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 787738413 362 GIGMSDDALQRAFEPFFraeSDRPQGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCF 422
Cdd:COG3852  295 GPGIPEEILDRIFEPFF---TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
MtrAB_MtrB NF040691
MtrAB system histidine kinase MtrB;
217-394 7.50e-23

MtrAB system histidine kinase MtrB;


Pssm-ID: 468655 [Multi-domain]  Cd Length: 507  Bit Score: 100.48  E-value: 7.50e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 217 FTRDASHELRTPLTVIRVATD-IAMTDPDLPPRLNRSLQRIQRAGRDMEAVIDAFLILAR-EADVVP-QSETFEVADVIE 293
Cdd:NF040691 274 FVSDVSHELRTPLTTIRMAADvIHDSRDDFDPATARSAELLHTELDRFESLLSDLLEISRfDAGAAElDVEPVDLRPLVR 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 294 YEIENARELLSGKPVALSVRVLA-PVRLHAPPRVLHVVMSNLLRNACSYTDAGRIEVEVAEDR----ISIRDTGIGMSDD 368
Cdd:NF040691 354 RVVDALRQLAERAGVELRVDAPGtPVVAEVDPRRVERVLRNLVVNAIEHGEGKPVVVTVAQDDtavaVTVRDHGVGLKPG 433

                        170       180
                 ....*....|....*....|....*....
gi 787738413 369 ALQRAFEPFFRAESDRPQ---GTGLGLSI 394
Cdd:NF040691 434 EVALVFDRFWRADPARARttgGTGLGLAI 462
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 330-421 1.69e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 91.79  E-value: 1.69e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 330 VMSNLLRNACSYTDAGRIEVEVAED---------RISIRDTGIGMSDDALQRAFEPFFRAESD---RPQGTGLGLSIVHR 397
Cdd:cd16922    4 ILLNLLGNAIKFTEEGEVTLRVSLEeeeedgvqlRFSVEDTGIGIPEEQQARLFEPFSQADSSttrKYGGTGLGLAISKK 83

                         90       100
                 ....*....|....*....|....
gi 787738413 398 LCDRFGWRVGLESAEGGGITATVC 421
Cdd:cd16922   84 LVELMGGDISVESEPGQGSTFTFT 107
KinB COG5806
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
 222-426 1.12e-20

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 93.39  E-value: 1.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 222 SHELRTPLTVIRVATDIAMTDPDLPPRLNR----SLQRIQRAgrdmEAVIDAFLILAReadvvPQSETFEVADVIEyEIE 297
Cdd:COG5806  209 AHEVRNPLTVVRGFIQLLQEPELSDEKRKQyiriALEELDRA----EAIITDYLTFAK-----PQPEKLEKIDVSE-ELE 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 298 NARELLS----GKPVALSVRVLAPVRLHAPPRVLHVVMSNLLRNAC-SYTDAGRIEVEVAEDR----ISIRDTGIGMSDD 368
Cdd:COG5806  279 HVIDVLSpyanMNNVEIQTELEPGLYIEGDRQKLQQCLINIIKNGIeAMPNGGTLTIDVSIDKnkviISIKDTGVGMTKE 358

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 787738413 369 ALQRAFEPFFraeSDRPQGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCFdPAK 426
Cdd:COG5806  359 QLERLGEPYF---STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITL-PLA 412
BaeS_SmeS NF012163
sensor histidine kinase efflux regulator BaeS;
217-422 1.07e-19

sensor histidine kinase efflux regulator BaeS;


Pssm-ID: 411086 [Multi-domain]  Cd Length: 457  Bit Score: 90.66  E-value: 1.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 217 FTRDASHELRTPLTVIRVATDiAMTDpDLPPRLNRSLQRIQRAGRDMEAVID--AFLILAREADVVPQSETFEVADVIEY 294
Cdd:NF012163 243 FMADISHELRTPLAVLRAELE-AIQD-GIRKFTPESLDSLQAEVGTLTKLVDdlHDLSMSDEGALAYQKASVDLVPLLEV 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 295 EIENARELLSGKPVALSVRVLAPVRLHAPPRVLHVVMSNLLRNACSYTDA-GRIEVEVAED----RISIRDTGIGMSDDA 369
Cdd:NF012163 321 EGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSgGSLHISASQRpkevTLTVADSAPGVSDEQ 400

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 787738413 370 LQRAFEPFFRAESDR---PQGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCF 422
Cdd:NF012163 401 LARLFERFYRVEVSRnraSGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTL 456
envZ PRK09467
osmolarity sensor protein; Provisional
 222-422 1.15e-19

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 90.35  E-value: 1.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 222 SHELRTPLTVIRVATDIaMTDPD--LPPRLNRSLQriqragrDMEAVIDAFLILAREAdvvpQSETFEVADV-------- 291
Cdd:PRK09467 237 SHDLRTPLTRIRLATEM-MSEEDgyLAESINKDIE-------ECNAIIEQFIDYLRTG----QEMPMEMADLnallgevi 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 292 -----IEYEIENArelLSGKPVALSVRVLAPVRlhapprvlhvVMSNLLRNACSYTdAGRIEVEVAEDR----ISIRDTG 362
Cdd:PRK09467 305 aaesgYEREIETA---LQPGPIEVPMNPIAIKR----------ALANLVVNAARYG-NGWIKVSSGTEGkrawFQVEDDG 370

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 787738413 363 IGMSDDALQRAFEPFFRAESDR-PQGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCF 422
Cdd:PRK09467 371 PGIPPEQLKHLFQPFTRGDSARgSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWL 431
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 223-422 2.05e-19

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 89.90  E-value: 2.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 223 HELRTPLTVIRVATDIAMTDPDlPPRLNRSLQRIQRAGRDMEAVIDAFLILAR-EADVVPQ-SETFEVADVIEyEIENAR 300
Cdd:PRK11100 265 HELKSPLAAIRGAAELLQEDPP-PEDRARFTGNILTQSARLQQLIDRLLELARlEQRQELEvLEPVALAALLE-ELVEAR 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 301 EL-LSGKPVALSVRVlAPVRLHAPPRVLHVVMSNLLRNACSYTDAG---RIEVEVAED--RISIRDTGIGMSDDALQRAF 374
Cdd:PRK11100 343 EAqAAAKGITLRLRP-DDARVLGDPFLLRQALGNLLDNAIDFSPEGgtiTLSAEVDGEqvALSVEDQGPGIPDYALPRIF 421

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 787738413 375 EPFF---RAESDRpQGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCF 422
Cdd:PRK11100 422 ERFYslpRPANGR-KSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTL 471
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 315-420 3.21e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 82.84  E-value: 3.21e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 315 LAPVRLHAPPRVLHVVMSNLLRNACSYTDAG-RIEVEVAEDR---ISIRDTGIGMSDDALQRAFEPFFRAESDRPQGTGL 390
Cdd:cd16940    2 AADIQVQGDALLLFLLLRNLVDNAVRYSPQGsRVEIKLSADDgavIRVEDNGPGIDEEELEALFERFYRSDGQNYGGSGL 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 787738413 391 GLSIVHRLCDRFGWRVGLESAEGGGITATV 420
Cdd:cd16940   82 GLSIVKRIVELHGGQIFLGNAQGGGLEAWV 111
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
223-420 8.02e-19

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 88.87  E-value: 8.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 223 HELRTPLTVIRVATDIAMTDPDLPPRlNRSLQRIQRAGRDMEAVIDAFLILAREADVVPQS--------------ETFEV 288
Cdd:PRK11360 399 HEIRNPLTAIRGYVQIWRQQTSDPPS-QEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQPvslnalveevlqlfQTAGV 477

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 289 ADVIEYEIENARELlsgkPVALsvrvlapvrlhAPPRVLHVVMSNLLRNACSYTDAG---RIEVEVAEDR---ISIRDTG 362
Cdd:PRK11360 478 QARVDFETELDNEL----PPIW-----------ADPELLKQVLLNILINAVQAISARgkiRIRTWQYSDGqvaVSIEDNG 542

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 787738413 363 IGMSDDALQRAFEPFFraeSDRPQGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATV 420
Cdd:PRK11360 543 CGIDPELLKKIFDPFF---TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTL 597
TMAO_torS TIGR02956
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ...
 222-426 1.21e-17

TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]


Pssm-ID: 274362 [Multi-domain]  Cd Length: 968  Bit Score: 85.60  E-value: 1.21e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  222 SHELRTPLTVIrVATDIAMTDPDLPPRLNRSLQRIQRAGRDMEAVIDAFLILAR-EADVVPQSET-FEVADVIE--YEIE 297
Cdd:TIGR02956 472 SHEIRTPLNGI-LGTLELLGDTGLTSQQQQYLQVINRSGESLLDILNDILDYSKiEAGHLSISPRpFDLNALLDdvHHLM 550

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  298 NARELLSGKPVALSVRVLAPVRLHAPPRVLHVVMSNLLRNACSYTDAG--RIEVEVAEDR---ISIRDTGIGMSDDALQR 372
Cdd:TIGR02956 551 VSRAQLKGIQLRLNIPEQLPNWWQGDGPRIRQVLINLVGNAIKFTDRGsvVLRVSLNDDSsllFEVEDTGCGIAEEEQAT 630

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 787738413  373 AFEPFFRAESDRPQ-GTGLGLSIVHRLCDRFGWRVGLESAEGGGIT--ATVCFDPAK 426
Cdd:TIGR02956 631 LFDAFTQADGRRRSgGTGLGLAISQRLVEAMDGELGVESELGVGSCfwFTLPLTRGK 687
HK_WalK NF033092
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ...
 207-417 1.75e-16

cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.


Pssm-ID: 467964 [Multi-domain]  Cd Length: 594  Bit Score: 81.34  E-value: 1.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 207 VTEH--VAREH-NFTRDASHELRTPLTVIR----VATDIAMTDPDLPPRLnrsLQRIQRAGRDMEAVIDAFLILAR--EA 277
Cdd:NF033092 362 VTEQekIEQERrEFVANVSHELRTPLTTMRsyleALADGAWKDPELAPRF---LGVTQNETERMIRLVNDLLQLSRmdSK 438

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 278 DVVPQSETFEVADVIEYEIENARELLSGKPVALSVRVlapvrlhaPPRVLHV---------VMSNLLRNACSYT-DAGRI 347
Cdd:NF033092 439 DYKLNKEWVNFNEFFNYIIDRFEMILKNKNITFKREF--------PKRDLWVeidtdkitqVLDNIISNAIKYSpEGGTI 510

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 787738413 348 EVEVAEDR----ISIRDTGIGMSDDALQRAFEPFFR---AESdRPQ-GTGLGLSIVHRLCDRFGWRVGLESAEGGGIT 417
Cdd:NF033092 511 TFRLLETHnriiISISDQGLGIPKKDLDKIFDRFYRvdkARS-RKMgGTGLGLAIAKEVVEAHGGRIWAESEEGKGTT 587
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
217-420 1.96e-16

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 80.83  E-value: 1.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 217 FTRDASHELRTPLTVIRVATDiAMTD----PDlPPRLNrSLQriqragrdMEAVIDAFLI-------LAREADVVPQSET 285
Cdd:PRK10549 243 FMADISHELRTPLAVLRGELE-AIQDgvrkFT-PESVA-SLQ--------AEVGTLTKLVddlhqlsLSDEGALAYRKTP 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 286 FEVADVIEYEIENARELLSGKPVALSVRVLAPVRLHAPPRVLHVVMSNLLRNACSYTDAG---RIEVEVAEDR--ISIRD 360
Cdd:PRK10549 312 VDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGgslHISAEQRDKTlrLTFAD 391

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 787738413 361 TGIGMSDDALQRAFEPFFRAESDRPQ---GTGLGLSIVHRLCDRFGWRVGLESAEGGGITATV 420
Cdd:PRK10549 392 SAPGVSDEQLQKLFERFYRTEGSRNRasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITV 454
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
216-417 2.42e-16

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 80.44  E-value: 2.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 216 NFTRDASHELRTPLTVIRVATDIaMTDPDLPPRLN-RSLQRIQRAGRDMEAVIDAFLILAR-EAdvVPQSETFEVADV-- 291
Cdd:PRK11006 206 NFFANVSHELRTPLTVLQGYLEM-MQDQPLEGALReKALHTMREQTQRMEGLVKQLLTLSKiEA--APTIDLNEKVDVpm 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 292 ----IEYEIENarelLSGKPVALSVRVLAPVRLHAPPRVLHVVMSNLLRNACSYTDAG-RIEVE----VAEDRISIRDTG 362
Cdd:PRK11006 283 mlrvLEREAQT----LSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGtHITVRwqrvPQGAEFSVEDNG 358

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 787738413 363 IGMSDDALQRAFEPFFR---AESDRPQGTGLGLSIVHRLCDRFGWRVGLESAEGGGIT 417
Cdd:PRK11006 359 PGIAPEHIPRLTERFYRvdkARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTR 416
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-422 6.48e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 73.13  E-value: 6.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 327 LHVVMSNLLRNACSYT---DAGRIEV---EVAED-RISIRDTGIGMSDDALQRAFEPFFRAESDRP-QGTGLGLSIVHRL 398
Cdd:cd16921    1 LGQVLTNLLGNAIKFRrprRPPRIEVgaeDVGEEwTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEyEGTGVGLAIVRKI 80

                         90       100
                 ....*....|....*....|....
gi 787738413 399 CDRFGWRVGLESAEGGGitATVCF 422
Cdd:cd16921   81 IERHGGRIWLESEPGEG--TTFYF 102
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
222-398 3.99e-15

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 77.71  E-value: 3.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 222 SHELRTPLTVIRVATDIAMTDpDLPPRLNRSLQRIQRAGRDMEAVIDAFL----ILAREADVVPQSetFEVADVIEYEIE 297
Cdd:PRK10841 455 SHELRTPLYGIIGNLDLLQTK-ELPKGVDRLVTAMNNSSSLLLKIISDILdfskIESEQLKIEPRE--FSPREVINHITA 531

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 298 NARELLSGKPVAL------SVrvlaPVRLHAPPRVLHVVMSNLLRNACSYTDAGRIEVEVAEDR----ISIRDTGIGMSD 367
Cdd:PRK10841 532 NYLPLVVKKRLGLycfiepDV----PVALNGDPMRLQQVISNLLSNAIKFTDTGCIVLHVRVDGdylsFRVRDTGVGIPA 607

                        170       180       190
                 ....*....|....*....|....*....|....
gi 787738413 368 DALQRAFEPFFRAESD---RPQGTGLGLSIVHRL 398
Cdd:PRK10841 608 KEVVRLFDPFFQVGTGvqrNFQGTGLGLAICEKL 641
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-422 4.16e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 70.78  E-value: 4.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 327 LHVVMSNLLRNACSYTD-AGRIEVEVAED----RISIRDTGIGMSDDALQRAFEPFFRAESDRPQG--TGLGLSIVHRLC 399
Cdd:cd16948    6 LSFIIGQIVSNALKYSKqGGKIEIYSETNeqgvVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQesTGMGLYLVKKLC 85

                         90       100
                 ....*....|....*....|...
gi 787738413 400 DRFGWRVGLESAEGGGITATVCF 422
Cdd:cd16948   86 DKLGHKIDVESEVGEGTTFTITF 108
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 324-422 6.01e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 70.57  E-value: 6.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 324 PRVLHVVMSNLLRNACSYTDAG-RIEVEVAED----RISIRDTGIGMSDDALQRAFEPFFRAESDRPQ---GTGLGLSIV 395
Cdd:cd16946    2 RDRLQQLFVNLLENSLRYTDTGgKLRIRAAQTpqevRLDVEDSAPGVSDDQLARLFERFYRVESSRNRasgGSGLGLAIC 81

                         90       100
                 ....*....|....*....|....*..
gi 787738413 396 HRLCDRFGWRVGLESAEGGGITATVCF 422
Cdd:cd16946   82 HNIALAHGGTISAEHSPLGGLRLVLTL 108
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 222-415 7.29e-15

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 76.87  E-value: 7.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 222 SHELRTPLTVIrVATDIAMTDPDLPPRLNRSLQRIQRAGRDMEAVIDAFL----ILAREADVVPQSETFEVADVIEYEIE 297
Cdd:PRK11466 452 SHEIRTPLYGI-LGTAQLLADNPALNAQRDDLRAITDSGESLLTILNDILdysaIEAGGKNVSVSDEPFEPRPLLESTLQ 530

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 298 NARELLSGKPVALSVRV--LAPVRLHAPPRVLHVVMSNLLRNACSYTDAGRIEVEVAEDR----ISIRDTGIGMSDDALQ 371
Cdd:PRK11466 531 LMSGRVKGRPIRLATDIadDLPTALMGDPRRIRQVITNLLSNALRFTDEGSIVLRSRTDGeqwlVEVEDSGCGIDPAKLA 610

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 787738413 372 RAFEPFFRAeSDRPQGTGLGLSIVHRLCDRFGWRVGLESAEGGG 415
Cdd:PRK11466 611 EIFQPFVQV-SGKRGGTGLGLTISSRLAQAMGGELSATSTPEVG 653
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 330-423 7.42e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 70.17  E-value: 7.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 330 VMSNLLRNACSYtdaGRIEVEVAED------RISIRDTGIGMSDDALQRAFEPFFRAESDR-PQGTGLGLSIVHRLCDRF 402
Cdd:cd16950    4 VLSNLVDNALRY---GGGWVEVSSDgegnrtRIQVLDNGPGIAPEEVDELFQPFYRGDNARgTSGTGLGLAIVQRISDAH 80

                         90       100
                 ....*....|....*....|.
gi 787738413 403 GWRVGLESAEGGGITATVCFD 423
Cdd:cd16950   81 GGSLTLANRAGGGLCARIELP 101
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
205-422 7.81e-15

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 75.39  E-value: 7.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 205 QRVTEHVAREHNFTRDASHELRTPLTVIRVATDI--AMTDPDLPPRlnrsLQRIQRagrdMEAVIDAFLILAReadvVPQ 282
Cdd:PRK10755 128 SRLTSTLDQERLFTADVAHELRTPLAGIRLHLELleKQHHIDVAPL----IARLDQ----MMHTVEQLLQLAR----AGQ 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 283 S------ETFE-VADVIEYEIENARELLSGKPVALSVR-VLAPVRLHAPPRVLHVVMSNLLRNACSYTDAG-RIEVEVAE 353
Cdd:PRK10755 196 SfssghyQTVKlLEDVILPSQDELSEMLEQRQQTLLLPeSAADITVQGDATLLRLLLRNLVENAHRYSPEGsTITIKLSQ 275

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 787738413 354 D----RISIRDTGIGMSDDALQRAFEPFFRAESdRPQGTGLGLSIVHRLCDRFGWRVGLES-AEGGGITATVCF 422
Cdd:PRK10755 276 EdggaVLAVEDEGPGIDESKCGELSKAFVRMDS-RYGGIGLGLSIVSRITQLHHGQFFLQNrQERSGTRAWVWL 348
PRK15347 PRK15347
two component system sensor kinase;
206-423 1.42e-14

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 75.83  E-value: 1.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 206 RVTEHVArehnftrDASHELRTPLTVIRVATDIAMTDPdLPPRLNRSLQRIQRAGRDMEAVIDAFLILAR-EAD---VVP 281
Cdd:PRK15347 397 RKSEHLT-------TISHEIRTPLNGVLGALELLQNTP-LTAEQMDLADTARQCTLSLLAIINNLLDFSRiESGqmtLSL 468

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 282 QS-ETFEVADVIEYEIEN-AREllsgKPVALSVRVLA--PVRLHAPPRVLHVVMSNLLRNACSYTDAGRI--EVEVAEDR 355
Cdd:PRK15347 469 EEtALLPLLDQAMLTIQGpAQS----KSLTLRTFVGAhvPLYLHLDSLRLRQILVNLLGNAVKFTETGGIrlRVKRHEQQ 544

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 356 --ISIRDTGIGMSDDALQRAFEPFFRAEsDRPQGTGLGLSIVHRLCDRFGWRVGLESAEGGGitATVCFD 423
Cdd:PRK15347 545 lcFTVEDTGCGIDIQQQQQIFTPFYQAD-THSQGTGLGLTIASSLAKMMGGELTLFSTPGVG--SCFSLV 611
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 222-423 1.87e-14

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 75.01  E-value: 1.87e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 222 SHELRTPLTVIRVATDI--AMTDPDLPPRLNRSLQRIQRagrdMEAVIDAFLILAReadvvPQSETFEVADVIEYeIENA 299
Cdd:COG5809  278 AHEIRNPLTSLKGFIQLlkDTIDEEQKTYLDIMLSELDR----IESIISEFLVLAK-----PQAIKYEPKDLNTL-IEEV 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 300 RELLSgkPVALSVRVlaPVRLHAPPRVLHVVMS---------NLLRNAC-SYTDAGRIEVEVAED-----RISIRDTGIG 364
Cdd:COG5809  348 IPLLQ--PQALLKNV--QIELELEDDIPDILGDenqlkqvfiNLLKNAIeAMPEGGNITIETKAEdddkvVISVTDEGCG 423

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 787738413 365 MSDDALQRAFEPFFraeSDRPQGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCFD 423
Cdd:COG5809  424 IPEERLKKLGEPFY---TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 323-420 1.89e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 68.99  E-value: 1.89e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 323 PPRVLHVVMsNLLRNACSYTDA-GRIEVEVAED----RISIRDTGIGMSDDALQRAFEPFFraeSDRP--QGTGLGLSIV 395
Cdd:cd16943    1 PSQLNQVLL-NLLVNAAQAMEGrGRITIRTWAHvdqvLIEVEDTGSGIDPEILGRIFDPFF---TTKPvgEGTGLGLSLS 76

                         90       100
                 ....*....|....*....|....*
gi 787738413 396 HRLCDRFGWRVGLESAEGGGITATV 420
Cdd:cd16943   77 YRIIQKHGGTIRVASVPGGGTRFTI 101
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
220-395 3.37e-14

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 74.20  E-value: 3.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 220 DASHELRTPLTVIRVATDIAMTdpdlppRLNRS--LQRIQRAGRDMEAVIDAFLILAR-------EADVVPQSETFEvaD 290
Cdd:PRK09470 249 DISHELRTPLTRLQLATALLRR------RQGESkeLERIETEAQRLDSMINDLLVLSRnqqknhlERETFKANSLWS--E 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 291 VIE---YEIENarellSGKPVALSVrVLAPVRLHAPPRVLHVVMSNLLRNACSYTDAgRIEVEVAEDR----ISIRDTGI 363
Cdd:PRK09470 321 VLEdakFEAEQ-----MGKSLTVSA-PPGPWPINGNPNALASALENIVRNALRYSHT-KIEVAFSVDKdgltITVDDDGP 393

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 787738413 364 GMSDDALQRAFEPFFRAESDRPQ---GTGLGLSIV 395
Cdd:PRK09470 394 GVPEEEREQIFRPFYRVDEARDResgGTGLGLAIV 428
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
222-415 2.82e-13

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 71.63  E-value: 2.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 222 SHELRTPLTVIRVATDIAMTDPDLPPRLNRSLQRIQRAGRDMEAVIDAFLILAREADVVpqSETFEVADVIEyeieNARE 301
Cdd:PRK13837 458 AHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQILAFGRKGERN--TKPFDLSELVT----EIAP 531

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 302 LLS---GKPVALSVRVLA-PVRLHAPPRVLHVVMSNLLRNAC-SYTDAGRIEVEVAED-------------------RIS 357
Cdd:PRK13837 532 LLRvslPPGVELDFDQDQePAVVEGNPAELQQVLMNLCSNAAqAMDGAGRVDISLSRAklrapkvlshgvlppgryvLLR 611

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 787738413 358 IRDTGIGMSDDALQRAFEPFFraeSDRPQGTGLGLSIVHRLCDRFGWRVGLESAEGGG 415
Cdd:PRK13837 612 VSDTGAGIDEAVLPHIFEPFF---TTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRG 666
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 327-422 3.30e-13

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 65.86  E-value: 3.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 327 LHVVMSNLLRNAcsyTDA----GRIEVEVAEDR-------------------ISIRDTGIGMSDDALQRAFEPFFraeSD 383
Cdd:cd16919    1 LELAILNLAVNA---RDAmpegGRLTIETSNQRvdadyalnyrdlipgnyvcLEVSDTGSGMPAEVLRRAFEPFF---TT 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 787738413 384 RP--QGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCF 422
Cdd:cd16919   75 KEvgKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
PRK10604 PRK10604
sensor protein RstB; Provisional
 222-422 4.68e-13

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 70.40  E-value: 4.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 222 SHELRTPLtvIRVATDIAMTD---PDLPPRLNRSLQRIqragrdmEAVIDAFLILAR--EADVVPQSETFEVADVIEYEI 296
Cdd:PRK10604 220 AHELRTPL--VRLRYRLEMSDnlsAAESQALNRDIGQL-------EALIEELLTYARldRPQNELHLSEPDLPAWLSTHL 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 297 ENARELLSGKPVALSVRVLAPVrLHAPPRVLHVVMSNLLRNACSYTDaGRIEVEVAED----RISIRDTGIGMSDDALQR 372
Cdd:PRK10604 291 ADIQAVTPEKTVRLDTPHQGDY-GALDMRLMERVLDNLLNNALRYAH-SRVRVSLLLDgnqaCLIVEDDGPGIPPEERER 368

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 787738413 373 AFEPFFRAESDRPQGTG---LGLSIVHRLCDRFGWRVGLESAEGGGitATVCF 422
Cdd:PRK10604 369 VFEPFVRLDPSRDRATGgcgLGLAIVHSIALAMGGSVNCDESELGG--ARFSF 419
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 330-423 5.44e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 64.79  E-value: 5.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 330 VMSNLLRNAcsyTDAG--------RIEVEVAEDR--ISIRDTGIGMSDDALQRAFEPFFraeSDRP--QGTGLGLSIVHR 397
Cdd:cd16976    4 VLMNLLQNA---LDAMgkvenpriRIAARRLGGRlvLVVRDNGPGIAEEHLSRVFDPFF---TTKPvgKGTGLGLSISYG 77

                         90       100
                 ....*....|....*....|....*.
gi 787738413 398 LCDRFGWRVGLESAEGGGitATVCFD 423
Cdd:cd16976   78 IVEEHGGRLSVANEEGAG--ARFTFD 101
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
178-410 6.02e-13

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 70.19  E-value: 6.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 178 AELAPENLPAEVQgesrQLALALHALAQRVTEHVAREHNFTRDASHELRTPLTVIRVATDIAM----TDPDLPPRLNRSL 253
Cdd:PRK09835 230 VRLDPQTVPIELE----QLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALsqsrSQKELEDVLYSNL 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 254 QRIQRagrdMEAVIDAFLILArEAD---VVPQSETFEVADVIEYEIENARELLSGKPVALSVrVLAPVRLHAPPRVLHVV 330
Cdd:PRK09835 306 EELTR----MAKMVSDMLFLA-QADnnqLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRF-VGDPCQVAGDPLMLRRA 379

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 331 MSNLLRNACSYTDAG-RIEVEVAED----RISIRDTGIGMSDDALQRAFEPFFRAESDRP---QGTGLGLSIVHRLCDRF 402
Cdd:PRK09835 380 ISNLLSNALRYTPAGeAITVRCQEVdhqvQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQrkgEGSGIGLAIVKSIVVAH 459


                 ....*...
gi 787738413 403 GWRVGLES 410
Cdd:PRK09835 460 KGTVAVTS 467
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
222-420 1.64e-12

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 68.66  E-value: 1.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 222 SHELRTPLTVIR-VATDIAMTDP------DLPPRLNRSLQRIQRagrdmeaVIDAFLILAREADVVPQSetFEVADVIEY 294
Cdd:PRK10364 245 AHEIRNPLSSIKgLAKYFAERAPaggeahQLAQVMAKEADRLNR-------VVSELLELVKPTHLALQA--VDLNDLINH 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 295 EIENARELLSGKPVALSVRVLAPV-RLHAPPRVLHVVMSNLLRNACSYTD-AGRIEVEVAED----RISIRDTGIGMSDD 368
Cdd:PRK10364 316 SLQLVSQDANSREIQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQAIGqHGVISVTASESgagvKISVTDSGKGIAAD 395

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 787738413 369 ALQRAFEPFFraeSDRPQGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATV 420
Cdd:PRK10364 396 QLEAIFTPYF---TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTL 444
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 330-422 3.67e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 63.42  E-value: 3.67e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 330 VMSNLLRNACSYTDaGRIEVEVAED----RISIRDTGIGMSDDALQRAFEPFFRAESDRPqGTGLGLSIVHRLCDRFGWR 405
Cdd:cd16954   41 LLGNLLDNACKWCL-EFVEVTARQTdgglHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP-GQGLGLAIAKEIVEQYGGE 118

                         90
                 ....*....|....*..
gi 787738413 406 VGLESAEGGGITATVCF 422
Cdd:cd16954  119 LSLSDSPLGGARFEVVF 135
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 325-415 3.71e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 62.55  E-value: 3.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 325 RVLHVVMSNLLRNACSYTDA-------GRIEVEV-AEDRIS--IRDTGIGMSDDALQRAFEPFFraeSDRPQGTGLGLSI 394
Cdd:cd16944    3 TQISQVLTNILKNAAEAIEGrpsdvgeVRIRVEAdQDGRIVliVCDNGKGFPREMRHRATEPYV---TTRPKGTGLGLAI 79

                         90       100
                 ....*....|....*....|.
gi 787738413 395 VHRLCDRFGWRVGLESAEGGG 415
Cdd:cd16944   80 VKKIMEEHGGRISLSNREAGG 100
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 217-275 6.77e-12

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 60.30  E-value: 6.77e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 787738413 217 FTRDASHELRTPLTVIRVATDIAMTDPDLPPRLNRSLQRIQRAGRDMEAVIDAFLILAR 275
Cdd:cd00082    7 FLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 216-275 8.88e-12

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 60.30  E-value: 8.88e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  216 NFTRDASHELRTPLTVIRVATDIaMTDPDLPPRLNRSLQRIQRAGRDMEAVIDAFLILAR 275
Cdd:pfam00512   4 EFLANLSHELRTPLTAIRGYLEL-LRDEKLDEEQREYLETILRSAERLLRLINDLLDLSR 62
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 253-422 9.99e-12

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 66.03  E-value: 9.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 253 LQRIQRAGRDMEAVIDAFLIlareadvvpQSETFEVADVIEYEIENARELlsGkpVALSVRVLAPVR-LHAPPRVLHVVM 331
Cdd:COG3290  220 LEYIDEISEELQELIDSLLS---------RIGNPVLAALLLGKAARARER--G--IDLTIDIDSDLPdLPLSDTDLVTIL 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 332 SNLLRNA---CSYTDAG--RIEVEVAED----RISIRDTGIGMSDDALQRAFEPFFraESDRPQGTGLGLSIVHRLCDRF 402
Cdd:COG3290  287 GNLLDNAieaVEKLPEEerRVELSIRDDgdelVIEVEDSGPGIPEELLEKIFERGF--STKLGEGRGLGLALVKQIVEKY 364

                        170       180
                 ....*....|....*....|
gi 787738413 403 GWRVGLESAEGGGITATVCF 422
Cdd:COG3290  365 GGTIEVESEEGEGTVFTVRL 384
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 222-417 1.19e-11

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 66.80  E-value: 1.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 222 SHELRTPLTVIrvatdIAMTDPDLPPRLNRS----LQRIQRAGRDMEAVIDAFLILAR-EAD-VVPQSETFEVADVIEyE 295
Cdd:PRK11107 301 SHELRTPLNGV-----IGFTRQTLKTPLTPTqrdyLQTIERSANNLLAIINDILDFSKlEAGkLVLENIPFSLRETLD-E 374

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 296 IENareLLSG----KPVALSVRVLAPVrlhaPPRV------LHVVMSNLLRNACSYTDAG----RIEVEVAED-----RI 356
Cdd:PRK11107 375 VVT---LLAHsaheKGLELTLNIDPDV----PDNVigdplrLQQIITNLVGNAIKFTESGnidiLVELRALSNtkvqlEV 447

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 787738413 357 SIRDTGIGMSDDALQRAFEPFFRAE---SDRPQGTGLGLSIVHRLCDRFGWRVGLESAEGGGIT 417
Cdd:PRK11107 448 QIRDTGIGISERQQSQLFQAFRQADasiSRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGST 511
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 330-422 1.30e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 60.87  E-value: 1.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 330 VMSNLLRNACSYTDAGR-------IEVEVAEDR---ISIRDTGIGMSDDALQRAFEPFFraeSDRPQGTGLGLSIVHRLC 399
Cdd:cd16920    4 VLINLVRNGIEAMSEGGcerreltIRTSPADDRavtISVKDTGPGIAEEVAGQLFDPFY---TTKSEGLGMGLSICRSII 80

                         90       100
                 ....*....|....*....|...
gi 787738413 400 DRFGWRVGLESAEGGGitATVCF 422
Cdd:cd16920   81 EAHGGRLSVESPAGGG--ATFQF 101
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-416 1.33e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 60.80  E-value: 1.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 327 LHVVMSNLLRNACSYTDaGRIEVEVAEDR----ISIRDTGIGMSDDALQRAFEPFFRAESDRPQ---GTGLGLSIVHRLC 399
Cdd:cd16949    1 LARALENVLRNALRYSP-SKILLDISQDGdqwtITITDDGPGVPEDQLEQIFLPFYRVDSARDResgGTGLGLAIAERAI 79

                         90
                 ....*....|....*..
gi 787738413 400 DRFGWRVGLESAEGGGI 416
Cdd:cd16949   80 EQHGGKIKASNRKPGGL 96
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-426 1.36e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 61.06  E-value: 1.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 327 LHVVMSNLLRNACSYT-DAGRIEVEVAED----RISIRDTGIGMSDDALQRAFEPFFRAESDRPQ---GTGLGLSIVHRL 398
Cdd:cd16952    1 LRSAFSNLVSNAVKYTpPSDTITVRWSQEesgaRLSVEDTGPGIPPEHIPRLTERFYRVDIERCRntgGTGLGLAIVKHV 80

                         90       100
                 ....*....|....*....|....*...
gi 787738413 399 CDRFGWRVGLESAEGGGITATVCFDPAK 426
Cdd:cd16952   81 MSRHDARLLIASELGKGSRFTCLFPSSR 108
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 223-422 6.32e-11

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 63.98  E-value: 6.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 223 HELRTPLTVIRvaTDIAMtdpdLPPRLNRS-------LQRIQRagrdMEAVIDAFLILAReadvvPQSETFEVADVIEyE 295
Cdd:COG5805  296 HEIRNPLTSIK--GFLQL----LQPGIEDKeeyfdimLSELDR----IESIISEFLALAK-----PQAVNKEKENINE-L 359

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 296 IENARELLSGKP----VALSVRVLAPV-RLHAPPRVLHVVMSNLLRNAC-SYTDAGRIEVEVAED----RISIRDTGIGM 365
Cdd:COG5805  360 IQDVVTLLETEAilhnIQIRLELLDEDpFIYCDENQIKQVFINLIKNAIeAMPNGGTITIHTEEEdnsvIIRVIDEGIGI 439

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 787738413 366 SDDALQRAFEPFFraeSDRPQGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCF 422
Cdd:COG5805  440 PEERLKKLGEPFF---TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITL 493
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-415 1.01e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 58.21  E-value: 1.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 327 LHVVMSNLLRNACSYTDAG-RIEVEVAEDRISIR--DTGIGMSDDALQRAFEPFFRAESDRPQGT---GLGLSIVHRLCD 400
Cdd:cd16939    1 MARALDNLLRNALRYAHRTvRIALLVSGGRLTLIveDDGPGIPAAARERVFEPFVRLDPSRDRATggfGLGLAIVHRVAL 80

                         90
                 ....*....|....*
gi 787738413 401 RFGWRVGLESAEGGG 415
Cdd:cd16939   81 WHGGHVECDDSELGG 95
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 216-275 1.10e-10

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 57.19  E-value: 1.10e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413   216 NFTRDASHELRTPLTVIRVATDIaMTDPDLPPRLNRSLQRIQRAGRDMEAVIDAFLILAR 275
Cdd:smart00388   4 EFLANLSHELRTPLTAIRGYLEL-LLDTELSEEQREYLETILREAERLLRLINDLLDLSR 62
PRK09303 PRK09303
histidine kinase;
223-415 2.11e-10

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 61.89  E-value: 2.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 223 HELRTPLTvirvATDIAM---------TDPDLPPRLNRSLQR-IQRAGRDMEAVIDAFLILAR----EADVVPQSetFEV 288
Cdd:PRK09303 160 HDLRTPLT----AASLALetlelgqidEDTELKPALIEQLQDqARRQLEEIERLITDLLEVGRtrweALRFNPQK--LDL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 289 ADVIEYEIENARELLSGKPVALSVRVlaPVRL---HAPPRVLHVVMSNLLRNACSYT-DAGRIEVeVAEDR------ISI 358
Cdd:PRK09303 234 GSLCQEVILELEKRWLAKSLEIQTDI--PSDLpsvYADQERIRQVLLNLLDNAIKYTpEGGTITL-SMLHRttqkvqVSI 310

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 787738413 359 RDTGIGMSDDALQRAFEPFFRAESDRPQ-GTGLGLSIVHRLCDRFGWRVGLESAEGGG 415
Cdd:PRK09303 311 CDTGPGIPEEEQERIFEDRVRLPRDEGTeGYGIGLSVCRRIVRVHYGQIWVDSEPGQG 368
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-420 3.53e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 57.09  E-value: 3.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 327 LHVVMSNLLRNACSYTDAGR---IEVEVAEDRIS--IRDTGIGMSDDALQRAFEPFFRAESDRPQGT--GLGLSIVHRLC 399
Cdd:cd16975    5 LSRALINIISNACQYAPEGGtvsISIYDEEEYLYfeIWDNGHGFSEQDLKKALELFYRDDTSRRSGGhyGMGLYIAKNLV 84

                         90       100
                 ....*....|....*....|.
gi 787738413 400 DRFGWRVGLESAEGGGITATV 420
Cdd:cd16975   85 EKHGGSLIIENSQKGGAEVTV 105
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 324-415 3.95e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 56.70  E-value: 3.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 324 PRVLHVVMSNLLRNACSYTDAG-----RIEVEVAEDRISIRDTGIGMSDDALQRAFEPFF---RAESDRpQGTGLGLSIV 395
Cdd:cd16945    2 PFLLRQAINNLLDNAIDFSPEGglialQLEADTEGIELLVFDEGSGIPDYALNRVFERFYslpRPHSGQ-KSTGLGLAFV 80

                         90       100
                 ....*....|....*....|
gi 787738413 396 HRLCDRFGWRVGLESAEGGG 415
Cdd:cd16945   81 QEVAQLHGGRITLRNRPDGV 100
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 317-410 4.05e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 57.14  E-value: 4.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 317 PVRLHAPPRVLHVVMSNLLRNACSYTDAGR-IEVEVAEDR----ISIRDTGIGMSDDALQRAFEPFFRAESDRP---QGT 388
Cdd:cd16947   11 PIYANANTEALQRILKNLISNAIKYGSDGKfLGMTLREDEkhvyIDIWDKGKGISETEKDHVFERLYTLEDSRNsakQGN 90

                         90       100
                 ....*....|....*....|..
gi 787738413 389 GLGLSIVHRLCDRFGWRVGLES 410
Cdd:cd16947   91 GLGLTITKRLAESMGGSIYVNS 112
PRK10490 PRK10490
sensor protein KdpD; Provisional
 222-422 1.46e-09

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 60.05  E-value: 1.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 222 SHELRTPLTVIRVATDIAMTDPDL-----PPRLNRSLQRIQRAGRdmeaVIDAFLILAReadvvPQSETFEV-------A 289
Cdd:PRK10490 672 SHDLRTPLTVLFGQAEILTLDLASegsphARQASEIRQQVLNTTR----LVNNLLDMAR-----IQSGGFNLrkewltlE 742

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 290 DVIEYEIENARELLSGKPVALSvrvlapvrLHAPPRVLHV-------VMSNLLRNACSYTDAGR---IEVEVAEDRISIR 359
Cdd:PRK10490 743 EVVGSALQMLEPGLSGHPINLS--------LPEPLTLIHVdgplferVLINLLENAVKYAGAQAeigIDAHVEGERLQLD 814

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 787738413 360 --DTGIGMSDDALQRAFEPFFRA--ESDRPqGTGLGLSIVHRLCDRFGWRVGLESAEGGGitatVCF 422
Cdd:PRK10490 815 vwDNGPGIPPGQEQLIFDKFARGnkESAIP-GVGLGLAICRAIVEVHGGTIWAENRPEGG----ACF 876
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 323-420 1.46e-09

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 55.19  E-value: 1.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 323 PPRVLHVVMsNLLRNACSYT-DAGRIEVEVAEDR-----ISIRDTGIGMSDDALQRAFEPFFRAESDRPQ---GTGLGLS 393
Cdd:cd16925    2 AEKYERVVL-NLLSNAFKFTpDGGRIRCILEKFRlnrflLTVSDSGPGIPPNLREEIFERFRQGDGSSTRahgGTGLGLS 80

                         90       100
                 ....*....|....*....|....*..
gi 787738413 394 IVHRLCDRFGWRVGLESAEGGGITATV 420
Cdd:cd16925   81 IVKEFVELHGGTVTVSDAPGGGALFQV 107
PRK13557 PRK13557
histidine kinase; Provisional
 356-425 3.84e-09

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 58.53  E-value: 3.84e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 356 ISIRDTGIGMSDDALQRAFEPFFRAEsDRPQGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCFdPA 425
Cdd:PRK13557 327 IAVTDTGSGMPPEILARVMDPFFTTK-EEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYF-PA 394
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
192-420 6.18e-09

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 58.21  E-value: 6.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  192 ESRQLALALHALAQRVTEHVAREHNFTRDASHELRTPLTVIRVATDIAMTDPDLPPRLNRSLQRIQRAGRDMEAVIDAFL 271
Cdd:PRK09959  690 ETRDLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEIL 769

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  272 ILAR--EADVVPQSETFEVADVIEYEIENARELLSGKPVALSVRVLAP--VRLHAPPRVLHVVMSNLLRNACSYTDAGRI 347
Cdd:PRK09959  770 DVDKieSGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTFPdhYLVKIDPQAFKQVLSNLLSNALKFTTEGAV 849

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  348 EVEVA----ED-----RISIRDTGIGMSDDALQRAFEPFFRAESDRPQ-GTGLGLSIVHRLCDRFGWRVGLESAEGGGIT 417
Cdd:PRK09959  850 KITTSlghiDDnhaviKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQtGSGLGLMICKELIKNMQGDLSLESHPGIGTT 929


                  ...
gi 787738413  418 ATV 420
Cdd:PRK09959  930 FTI 932
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
318-422 2.18e-08

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 55.79  E-value: 2.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 318 VRLHAPPRVLHVVM-----SNLLRNAC-----SYTDAGRIEVEVAED----RISIRDTGIGMSDDALQRAFEPFfraeSD 383
Cdd:COG2972  323 VEIEIDEELLDLLIpklilQPLVENAIehgiePKEGGGTIRISIRKEgdrlVITVEDNGVGMPEEKLEKLLEEL----SS 398

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 787738413 384 RPQGTGLGLSIVH-RLCDRFGWRVGL--ESAEGGGITATVCF 422
Cdd:COG2972  399 KGEGRGIGLRNVReRLKLYYGEEYGLeiESEPGEGTTVTIRI 440
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 330-395 6.77e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 50.08  E-value: 6.77e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 787738413 330 VMSNLLRNACSYT-DAGRIEVEVAED----RISIRDTGIGMSDDALQRAFEPFFRAESDR-PQGTGLGLSIV 395
Cdd:cd16923    4 VFSNLLSNAIKYSpENTRIYITSFLTddvvNIMFKNPSSHPLDFKLEKLFERFYRGDNSRnTEGAGLGLSIA 75
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 355-413 8.13e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 50.09  E-value: 8.13e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 787738413 355 RISIRDTGIGMSDDALQRAFEPFFraeSDRPQGTGLGLSIVHRLCDRFGWRVGLESAEG 413
Cdd:cd16918   45 RVSVIDNGPGIPPDLQDTIFYPMV---SGRENGTGLGLAIAQNIVSQHGGVIECDSQPG 100
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 222-420 1.41e-07

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 53.79  E-value: 1.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 222 SHELRTPLTVIRVATDIAMtDPDLPPRLNRSLQRIQRA----GRDMEAVIDAFLILAREADVVPQSETFEvaDVIEyEIE 297
Cdd:PRK11091 291 SHELRTPLNGIVGLSRILL-DTELTAEQRKYLKTIHVSaitlGNIFNDIIDMDKMERRKLQLDNQPIDFT--DFLA-DLE 366

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 298 NARELLSgKPVALSVrVLAPvRLHAPPRV------LHVVMSNLLRNACSYTDAGRIEVEVAED-----RISIRDTGIGMS 366
Cdd:PRK11091 367 NLSGLQA-EQKGLRF-DLEP-LLPLPHKVitdgtrLRQILWNLISNAVKFTQQGGVTVRVRYEegdmlTFEVEDSGIGIP 443

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 787738413 367 DDALQRAFEPFFRAES---DRPQ-GTGLGLSIVHRLCDRFGWRVGLESAEGGGITATV 420
Cdd:PRK11091 444 EDELDKIFAMYYQVKDshgGKPAtGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTL 501
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 330-422 4.86e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 47.95  E-value: 4.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 330 VMSNLLRNACSYT--DAGRIEVEVAED----RISIRDTGIGMSDDALQRAFEPFFraeSDRP------QGTGLGLSIVHR 397
Cdd:cd16953    4 VLRNLIGNAISFSppDTGRITVSAMPTgkmvTISVEDEGPGIPQEKLESIFDRFY---TERPaneafgQHSGLGLSISRQ 80

                         90       100
                 ....*....|....*....|....*
gi 787738413 398 LCDRFGWRVGLESAEGGGITATVCF 422
Cdd:cd16953   81 IIEAHGGISVAENHNQPGQVIGARF 105
marine_sort_HK TIGR03785
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ...
 216-420 5.59e-07

proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.


Pssm-ID: 163497 [Multi-domain]  Cd Length: 703  Bit Score: 51.67  E-value: 5.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  216 NFTRDASHELRTPLTVIRVATDIAMTDPDlpprlnrSLQRIQRAGRDMEAV--IDAFLILAREADVVPQS------ETFE 287
Cdd:TIGR03785 487 NMSSRLSHELRTPVAVVRSSLENLELQAL-------EQEKQKYLERAREGTerLSMILNNMSEATRLEQAiqsaevEDFD 559

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  288 VADVIEYEIENARELLSGKPVALSVRVlAPVRLHAPPRVLHVVMSNLLRNACSYT-DAGRIEVEVAEDR----ISIRDTG 362
Cdd:TIGR03785 560 LSEVLSGCMQGYQMTYPPQRFELNIPE-TPLVMRGSPELIAQMLDKLVDNAREFSpEDGLIEVGLSQNKshalLTVSNEG 638

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 787738413  363 IGMSDDALQRAFEPFFraeSDRPQGT------GLGLSIVHRLCDRFGWRVGLES-AEGGGITATV 420
Cdd:TIGR03785 639 PPLPEDMGEQLFDSMV---SVRDQGAqdqphlGLGLYIVRLIADFHQGRIQAENrQQNDGVVFRI 700
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
331-414 2.61e-06

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 46.44  E-value: 2.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 331 MSNLLRNACSYTDAGRIEVEVAED----RISIRDTGIGMSDDALQRAFEPffraesdrPQGTGLGLSIVHRLCDRFGWrv 406
Cdd:COG2172   43 VTNAVRHAYGGDPDGPVEVELELDpdglEIEVRDEGPGFDPEDLPDPYST--------LAEGGRGLFLIRRLMDEVEY-- 112


                 ....*...
gi 787738413 407 glESAEGG 414
Cdd:COG2172  113 --ESDPGG 118
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 222-415 2.81e-06

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 49.68  E-value: 2.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 222 SHELRTPLTVIR--VATDIAMTDPDLPPRLNRSLQRIQRAGRDMEAVIDAFLILAREADvvpqsETFEVADVIEYeIENA 299
Cdd:COG4192  441 AHELNQPLNAMSmyLFSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSD-----TPLQPVDLRQV-IEQA 514

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 300 RELLS--GKPVALSVRVLAPVRLHAPPRVLHVVMSNLLRNAC-SYTDAGRIEVEVAED----RISIRDTGIGMSDdaLQR 372
Cdd:COG4192  515 WELVEsrAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALdAVATQPQISVDLLSNaenlRVAISDNGNGWPL--VDK 592

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 787738413 373 AFEPFFraeSDRPQGTGLGLSIVHRLCDRFGWRVGLESA-EGGG 415
Cdd:COG4192  593 LFTPFT---TTKEVGLGLGLSICRSIMQQFGGDLYLASTlERGA 633
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 327-420 4.62e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 44.97  E-value: 4.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 327 LHVVMSNLLRNAcsyTDA--------GRIEVEVAED----RISIRDTGIGMSDDALQRAFEPFF--RAESDRpqgtGLGL 392
Cdd:cd16915    1 LITIVGNLIDNA---LDAlaatgapnKQVEVFLRDEgddlVIEVRDTGPGIAPELRDKVFERGVstKGQGER----GIGL 73

                         90       100
                 ....*....|....*....|....*...
gi 787738413 393 SIVHRLCDRFGWRVGLESAEGGGITATV 420
Cdd:cd16915   74 ALVRQSVERLGGSITVESEPGGGTTFSI 101
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 284-413 1.01e-05

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 47.59  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 284 ETFEVADVIEYEIENARELLSGKPVALSVRVlAPVRLhaPPR-------VLHVVMSNLLRNACSYTDAGRIEVEVAED-- 354
Cdd:COG3920  357 EGVDLRDYLRELLEPLRDSYGGRGIRIELDG-PDVEL--PADaavplglILNELVTNALKHAFLSGEGGRIRVSWRREdg 433

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 787738413 355 --RISIRDTGIGMSDDAlqrafepffraesDRPQGTGLGLSIVHRLCDRFGWRVGLESAEG 413
Cdd:COG3920  434 rlRLTVSDNGVGLPEDV-------------DPPARKGLGLRLIRALVRQLGGTLELDRPEG 481
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 323-408 2.36e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 43.20  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 323 PPRVLHVVMSNLLRNACS-YTDAGRIEVEVAED----RISIRDTGIGMSDDALQrafepffRAESDRPQGTGLGLSIVH- 396
Cdd:cd16924    2 PPFTLQPLVENAIQHGLSpLTDKGVVTISALKEdnhvMIEVEDNGRGIDPKVLN-------ILGKKPKEGNGIGLYNVHq 74

                         90
                 ....*....|..
gi 787738413 397 RLCDRFGWRVGL 408
Cdd:cd16924   75 RLILLFGEDYGI 86
PRK10618 PRK10618
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
 205-415 8.71e-05

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional


Pssm-ID: 236726 [Multi-domain]  Cd Length: 894  Bit Score: 44.92  E-value: 8.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 205 QRVTE--HVAReHNFTRDASHELRTPL-TVIRVATDIAMTDPDLP--PRLNRSLQRIQRAGRDMEaviDAFLILAREA-D 278
Cdd:PRK10618 440 QREYEknQQAR-KAFLQNIGDELKQPLqSLAQLAAQLRQTSDEEQqqPELDQLAEQSDVLVRLVD---NIQLLNMLETqD 515

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 279 VVPQSETFEVADVIEYEIENARELLSGKPVALSVRVLAPVR--LHAPPRVLHVVMSNLLRNACSYTDAGRIEVEV----- 351
Cdd:PRK10618 516 WKPEQELFSLQDLIDEVLPEVLPAIKRKGLQLLIHNHLKAEqlRIGDRDALRKILLLLLNYAITTTAYGKITLEVdqdes 595

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 787738413 352 AEDRISIR--DTGIGMSDDALQRAFEPFF-RAESDR-PQGTGLGLSIVHRLCDRFGWRVGLESAEGGG 415
Cdd:PRK10618 596 SPDRLTIRilDTGAGVSIKELDNLHFPFLnQTQGDRyGKASGLTFFLCNQLCRKLGGHLTIKSREGLG 663
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 221-420 1.89e-04

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 43.27  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 221 ASHELRTPLTVIR-VATDIAMTDPDLPP-----RLNRS--------LQRIQRAGRDMEAVIDaflilareadvvpqseTF 286
Cdd:NF033792 209 AAHELGTPLATIAlVAKELERELPDDPPlredaELLRSqaercrdiLRRLTSLGEEGDAHLD----------------RL 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 287 EVADVIEYEIENARELlsGKPVALSVrvlAPVRLHAP-----PRVLHvVMSNLLRNACSY-TDAGRIEVEVAEDRIS--I 358
Cdd:NF033792 273 PLSALIEEAAAPHRGF--GKEIEVVV---AGDPGEEPvirrnPEILY-GLGNLIENAVDFaRSTVTVTASWDAESVTitI 346

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 787738413 359 RDTGIGMSDDALQRAFEPFF---RAESDRP--QGTGLGLSIVHRLCDRFGWRVGLE--SAEGGGITATV 420
Cdd:NF033792 347 EDDGPGFPPDVLSRIGEPYVttrRGEERRPggGGLGLGLFIAKTLLERSGATVTFAnrPPPEGGAVVTV 415
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 327-405 4.68e-04

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 39.17  E-value: 4.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 327 LHVVMSNLLRNACSYTDA----GRIEVEVAED----RISIRDTGIGMsddALQRAFEPffraESDRPQGtGLGLSIVHRL 398
Cdd:cd16936    1 VELAVSEAVTNAVRHAYRhdgpGPVRLELDLDpdrlRVEVTDSGPGF---DPLRPADP----DAGLREG-GRGLALIRAL 72


                 ....*..
gi 787738413 399 CDRFGWR 405
Cdd:cd16936   73 MDEVGYR 79
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
156-395 6.87e-04

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 41.93  E-value: 6.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 156 LLSPVIWLARHvsqWDPRyPVAA-------------ELAPENLPAEVQGESRQLALALHALAQRVTehvaREHNFTRDAS 222
Cdd:PRK10815 203 LVIPLLWLAAW---WSLR-PIEAlakqvreleegerEQLDPNPPRELTSLVRNLNRLLKNERERYT----KYRTTLTDLT 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 223 HELRTPLTVIRVA---------TDIAMTDPDLPPRLNRSLQRI----QRAgrDMEAvidAFLILAREADVVP---QSETF 286
Cdd:PRK10815 275 HSLKTPLAVLQSTlrslrsgkqMSVEQAEPIMLEQISRISQQIgyylHRA--SMRS---EHNLLSRELHSVApllDNLTS 349

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 287 EVADVIEYeienarellsgKPVALSVRVlapvrlhaPPRVLHV--------VMSNLLRNACSYT-DAGRIEVEVAED--R 355
Cdd:PRK10815 350 ALNKVYQR-----------KGVNITLDI--------SPEITFVgekndfmeVMGNVLDNACKYClEFVEISARQTDEhlH 410

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 787738413 356 ISIRDTGIGMSDDALQRAFEPFFRAESDRPqGTGLGLSIV 395
Cdd:PRK10815 411 IVVEDDGPGIPESKRELIFDRGQRADTLRP-GQGLGLSVA 449
mutL PRK00095
DNA mismatch repair endonuclease MutL;
343-376 7.44e-04

DNA mismatch repair endonuclease MutL;


Pssm-ID: 234630 [Multi-domain]  Cd Length: 617  Bit Score: 41.74  E-value: 7.44e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 787738413 343 DAG--RIEVEVAE---DRISIRDTGIGMSDDALQRAFEP 376
Cdd:PRK00095  36 DAGatRIDIEIEEgglKLIRVRDNGCGISKEDLALALAR 74
MutL COG0323
DNA mismatch repair ATPase MutL [Replication, recombination and repair];
343-376 1.03e-03

DNA mismatch repair ATPase MutL [Replication, recombination and repair];


Pssm-ID: 440092 [Multi-domain]  Cd Length: 515  Bit Score: 41.18  E-value: 1.03e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 787738413 343 DAG--RIEVEVAE---DRISIRDTGIGMSDDALQRAFEP 376
Cdd:COG0323   37 DAGatRIEVEIEEggkSLIRVTDNGCGMSPEDLPLAFER 75
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 343-377 1.13e-03

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 39.73  E-value: 1.13e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 787738413 343 DAG--RIEVEVAE---DRISIRDTGIGMSDDALQRAFEPF 377
Cdd:cd16926   27 DAGatRIDVEIEEgglKLIRVTDNGSGISREDLELAFERH 66
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 327-411 1.81e-03

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 38.47  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413  327 LHVVMSNLLRNacSYT-DAGRIEVEV-----AEDRISIRDTGIGMSDDALQRAFEPFFRAESDRPQGTGLGlsivhrlcd 400
Cdd:pfam13589   1 LEGALAELIDN--SIDaDATNIKIEVnknrgGGTEIVIEDDGHGMSPEELINALRLATSAKEAKRGSTDLG--------- 69

                          90
                  ....*....|.
gi 787738413  401 RFGwrVGLESA 411
Cdd:pfam13589  70 RYG--IGLKLA 78
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
229-422 7.40e-03

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 38.06  E-value: 7.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 229 LTVIRVATD-IAMTDPDLPPRLNRSLQRIQRAGRDMEAVIDAFLILAREadvvPQSETFEVADVIEYEIENARELlSGKP 307
Cdd:COG4585   69 LSAIKLQLEaARRLLDADPEAAREELEEIRELAREALAELRRLVRGLRP----PALDDLGLAAALEELAERLLRA-AGIR 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 787738413 308 VALSVrVLAPVRLhaPPRVLHV---VMSNLLRNACSYTDAGRIEVEVAED----RISIRDTGIGMSDDAlqrafepffra 380
Cdd:COG4585  144 VELDV-DGDPDRL--PPEVELAlyrIVQEALTNALKHAGATRVTVTLEVDdgelTLTVRDDGVGFDPEA----------- 209

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 787738413 381 esdrPQGTGLGLSIVHRLCDRFGWRVGLESAEGGGITATVCF 422
Cdd:COG4585  210 ----APGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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