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Conserved domains on  [gi|814585410|ref|WP_046384619|]
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MULTISPECIES: type II toxin-antitoxin system MqsA family antitoxin [Pseudomonas]

Protein Classification

type II toxin-antitoxin system MqsA family antitoxin( domain architecture ID 11498933)

type II toxin-antitoxin system MqsA family antitoxin similar to Escherichia coli MqsA, the antitoxin component of the MqsR/MqsA TA system that is involved in the regulation of motility by quorum sensing signal autoinducer-2 (AI-2); binds to the MqsR mRNA interferase toxin and neutralizes its endoribonuclease activity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CxxCG_CxxCG_HTH TIGR03830
putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of ...
 6-136 9.91e-36

putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of predicted regulatory proteins with a conserved zinc finger/HTH architecture. The amino-terminal region contains a novel domain, featuring two CXXC motifs and occuring in a number of small bacterial proteins as well as in the present family. The carboxyl-terminal region consists of a helix-turn-helix domain, modeled by pfam01381. The predicted function is DNA binding and transcriptional regulation.


:

Pssm-ID: 274805 [Multi-domain]  Cd Length: 127  Bit Score: 120.43  E-value: 9.91e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 814585410    6 CVSCGTHDAMQHFegRNFTINTRGMIRDIpDIAGWECQACHEVEFDSDtdSAERYSDASDKLLMDARTII-AAEMKRIRR 84
Cdd:TIGR03830   1 CPICGKGELVREV--KDEPFTYKGESITI-GVPGWYCPACGEELFDPE--DSKRNSAALADFYRKVDGLLtGPEIRRIRK 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 814585410   85 KLHLTQKDAVRLLtGRGHNAFSRYERAEIFPPAPLLTLMRLLDKHPHLLAEI 136
Cdd:TIGR03830  76 KLGLSQREAAELL-GGGVNAFSRYERGEVRPSKALDKLLRLLDKHPELLEEL 126
 
Name Accession Description Interval E-value
CxxCG_CxxCG_HTH TIGR03830
putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of ...
 6-136 9.91e-36

putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of predicted regulatory proteins with a conserved zinc finger/HTH architecture. The amino-terminal region contains a novel domain, featuring two CXXC motifs and occuring in a number of small bacterial proteins as well as in the present family. The carboxyl-terminal region consists of a helix-turn-helix domain, modeled by pfam01381. The predicted function is DNA binding and transcriptional regulation.


Pssm-ID: 274805 [Multi-domain]  Cd Length: 127  Bit Score: 120.43  E-value: 9.91e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 814585410    6 CVSCGTHDAMQHFegRNFTINTRGMIRDIpDIAGWECQACHEVEFDSDtdSAERYSDASDKLLMDARTII-AAEMKRIRR 84
Cdd:TIGR03830   1 CPICGKGELVREV--KDEPFTYKGESITI-GVPGWYCPACGEELFDPE--DSKRNSAALADFYRKVDGLLtGPEIRRIRK 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 814585410   85 KLHLTQKDAVRLLtGRGHNAFSRYERAEIFPPAPLLTLMRLLDKHPHLLAEI 136
Cdd:TIGR03830  76 KLGLSQREAAELL-GGGVNAFSRYERGEVRPSKALDKLLRLLDKHPELLEEL 126
MqsA_antitoxin pfam15731
Antitoxin component of bacterial toxin-antitoxin system, MqsA; MqsA_antitoxin is a family of ...
 1-136 3.73e-26

Antitoxin component of bacterial toxin-antitoxin system, MqsA; MqsA_antitoxin is a family of prokaryotic proteins that act as antidotes to the mRNA interferase MqsR. It has a zinc-binding at the very N-terminus indicating its DNA-binding capacity. MqsR is the gene most highly upregulated in E. Colo MqsR_toxin is a family of bacterial toxins that act as an mRNA interferase. MqsR is the gene most highly upregulated in E. coli persister cells and it plays an essential role in biofilm regulation and cell signalling. It forms part of a bacterial toxin-antitoxin TA system, and as expected for a TA system, the expression of the MqsR toxin leads to growth arrest, while co-expression with its antitoxin, MqsA, rescues the growth arrest phenotype. In addition, MqsR associates with MqsA to form a tight, non-toxic complex and both MqsA alone and the MqsR:MqsA2:MqsR complex bind and regulate the mqsR promoter. The structure of MqsR shows that is is a member of the RelE/YoeB family of bacterial RNases that are structurally and functionally characterized bacterial toxins.


Pssm-ID: 292359 [Multi-domain]  Cd Length: 131  Bit Score: 96.29  E-value: 3.73e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 814585410    1 MKtqqCVSCGtHDAMQHfEGRNFTINTRGMIRDIPDIAGWECQACHEVEFDSDtdSAERYSDASDKLL--MDARTIIAAE 78
Cdd:pfam15731   1 MK---CPVCG-GAELVR-DTRDVPYTYKGEKTTIAAVTGDFCPACGEGVLDPE--EGDRYSALALAFNrqVNAVLIDPAF 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 814585410   79 MKRIRRKLHLTQKDAVRLLtGRGHNAFSRYERAEIFPPAPLLTLMRLLDKHPHLLAEI 136
Cdd:pfam15731  74 IARVRKKLGLDQREAAEIF-GGGVNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEI 130
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
69-133 1.02e-12

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 59.56  E-value: 1.02e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 814585410  69 MDARTIIAAEMKRIRRKLHLTQKDAVRLLtGRGHNAFSRYERAEIFPPAPLLTLMRLLDKHPHLL 133
Cdd:COG2944    1 MTKKPLTPEEIRALRERLGLSQAEFAALL-GVSVSTVRRWEQGRRKPSGAALKLLRLLEKHPELL 64
 
Name Accession Description Interval E-value
CxxCG_CxxCG_HTH TIGR03830
putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of ...
 6-136 9.91e-36

putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of predicted regulatory proteins with a conserved zinc finger/HTH architecture. The amino-terminal region contains a novel domain, featuring two CXXC motifs and occuring in a number of small bacterial proteins as well as in the present family. The carboxyl-terminal region consists of a helix-turn-helix domain, modeled by pfam01381. The predicted function is DNA binding and transcriptional regulation.


Pssm-ID: 274805 [Multi-domain]  Cd Length: 127  Bit Score: 120.43  E-value: 9.91e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 814585410    6 CVSCGTHDAMQHFegRNFTINTRGMIRDIpDIAGWECQACHEVEFDSDtdSAERYSDASDKLLMDARTII-AAEMKRIRR 84
Cdd:TIGR03830   1 CPICGKGELVREV--KDEPFTYKGESITI-GVPGWYCPACGEELFDPE--DSKRNSAALADFYRKVDGLLtGPEIRRIRK 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 814585410   85 KLHLTQKDAVRLLtGRGHNAFSRYERAEIFPPAPLLTLMRLLDKHPHLLAEI 136
Cdd:TIGR03830  76 KLGLSQREAAELL-GGGVNAFSRYERGEVRPSKALDKLLRLLDKHPELLEEL 126
MqsA_antitoxin pfam15731
Antitoxin component of bacterial toxin-antitoxin system, MqsA; MqsA_antitoxin is a family of ...
 1-136 3.73e-26

Antitoxin component of bacterial toxin-antitoxin system, MqsA; MqsA_antitoxin is a family of prokaryotic proteins that act as antidotes to the mRNA interferase MqsR. It has a zinc-binding at the very N-terminus indicating its DNA-binding capacity. MqsR is the gene most highly upregulated in E. Colo MqsR_toxin is a family of bacterial toxins that act as an mRNA interferase. MqsR is the gene most highly upregulated in E. coli persister cells and it plays an essential role in biofilm regulation and cell signalling. It forms part of a bacterial toxin-antitoxin TA system, and as expected for a TA system, the expression of the MqsR toxin leads to growth arrest, while co-expression with its antitoxin, MqsA, rescues the growth arrest phenotype. In addition, MqsR associates with MqsA to form a tight, non-toxic complex and both MqsA alone and the MqsR:MqsA2:MqsR complex bind and regulate the mqsR promoter. The structure of MqsR shows that is is a member of the RelE/YoeB family of bacterial RNases that are structurally and functionally characterized bacterial toxins.


Pssm-ID: 292359 [Multi-domain]  Cd Length: 131  Bit Score: 96.29  E-value: 3.73e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 814585410    1 MKtqqCVSCGtHDAMQHfEGRNFTINTRGMIRDIPDIAGWECQACHEVEFDSDtdSAERYSDASDKLL--MDARTIIAAE 78
Cdd:pfam15731   1 MK---CPVCG-GAELVR-DTRDVPYTYKGEKTTIAAVTGDFCPACGEGVLDPE--EGDRYSALALAFNrqVNAVLIDPAF 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 814585410   79 MKRIRRKLHLTQKDAVRLLtGRGHNAFSRYERAEIFPPAPLLTLMRLLDKHPHLLAEI 136
Cdd:pfam15731  74 IARVRKKLGLDQREAAEIF-GGGVNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEI 130
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
69-133 1.02e-12

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 59.56  E-value: 1.02e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 814585410  69 MDARTIIAAEMKRIRRKLHLTQKDAVRLLtGRGHNAFSRYERAEIFPPAPLLTLMRLLDKHPHLL 133
Cdd:COG2944    1 MTKKPLTPEEIRALRERLGLSQAEFAALL-GVSVSTVRRWEQGRRKPSGAALKLLRLLEKHPELL 64
YgiT_finger TIGR03831
YgiT-type zinc finger domain; This domain model describes a small domain with two copies of a ...
 6-53 1.45e-05

YgiT-type zinc finger domain; This domain model describes a small domain with two copies of a putative zinc-binding motif CXXC (usually CXXCG). Most member proteins consist largely of this domain or else carry an additional C-terminal helix-turn-helix domain, resembling that of the phage protein Cro and modeled by pfam01381.


Pssm-ID: 274806  Cd Length: 46  Bit Score: 40.40  E-value: 1.45e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 814585410    6 CVSCGtHDAMQHFEgRNFTINTRGMIRDIPDIAGWECQACHEVEFDSD 53
Cdd:TIGR03831   1 CPICG-GEELEGKT-TTETFEYGGELIVIENVPALVCPQCGEEYLDAE 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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