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Conserved domains on  [gi|835683245|ref|WP_047613903|]
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MULTISPECIES: hypothetical protein [Rhizobium]

Protein Classification

calponin homology domain-containing protein( domain architecture ID 289)

calponin homology (CH) domain-containing protein may bind actin filament (F-actin) or serve a regulatory function

CATH:  1.10.418.10
Gene Ontology:  GO:0008017
PubMed:  12186940|11911887

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CH_SF super family cl00030
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
80-114 1.55e-03

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


The actual alignment was detected with superfamily member cd21191:

Pssm-ID: 469584  Cd Length: 114  Bit Score: 36.40  E-value: 1.55e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 835683245  80 RVVSVEKGLGFQKDRNVAKISIDAASVEDGSVIAV 114
Cdd:cd21191   65 RLNNIAKALKFLEDSNVKLVSIDAAEIADGNPSLV 99
 
Name Accession Description Interval E-value
CH_CLMN_rpt1 cd21191
first calponin homology (CH) domain found in calmin and similar proteins; Calmin, also called ...
80-114 1.55e-03

first calponin homology (CH) domain found in calmin and similar proteins; Calmin, also called calponin-like transmembrane domain protein, is a protein with calponin homology (CH) and transmembrane domains expressed in maturing spermatogenic cells. It may be involved in the development and/or maintenance of neuronal functions. Calmin contains two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409040  Cd Length: 114  Bit Score: 36.40  E-value: 1.55e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 835683245  80 RVVSVEKGLGFQKDRNVAKISIDAASVEDGSVIAV 114
Cdd:cd21191   65 RLNNIAKALKFLEDSNVKLVSIDAAEIADGNPSLV 99
 
Name Accession Description Interval E-value
CH_CLMN_rpt1 cd21191
first calponin homology (CH) domain found in calmin and similar proteins; Calmin, also called ...
80-114 1.55e-03

first calponin homology (CH) domain found in calmin and similar proteins; Calmin, also called calponin-like transmembrane domain protein, is a protein with calponin homology (CH) and transmembrane domains expressed in maturing spermatogenic cells. It may be involved in the development and/or maintenance of neuronal functions. Calmin contains two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409040  Cd Length: 114  Bit Score: 36.40  E-value: 1.55e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 835683245  80 RVVSVEKGLGFQKDRNVAKISIDAASVEDGSVIAV 114
Cdd:cd21191   65 RLNNIAKALKFLEDSNVKLVSIDAAEIADGNPSLV 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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