|
Name |
Accession |
Description |
Interval |
E-value |
| GlyA |
COG0112 |
Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Glycine/serine ... |
4-421 |
1.38e-180 |
|
Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Glycine/serine hydroxymethyltransferase is part of the Pathway/BioSystem: Serine biosynthesis
Pssm-ID: 439882 Cd Length: 414 Bit Score: 509.96 E-value: 1.38e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 4 SATKASYKKILSDLQEHNKWFENSIPLIASENVPSPAVKEALLSDFGNRYAEGWPGERVYAGCVYIDKVEIECMNLAKKL 83
Cdd:COG0112 3 SSLAEVDPEIAEAIEKELERQEEGIELIASENFVSPAVLEAQGSVLTNKYAEGYPGKRYYGGCEYVDEVEQLAIERAKEL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 84 YKAKFADVRPISGVVANLAVYSAFTNPGDVMIAPSIPAGGHISHGKKehsGTAGlVHGLDIEFYPFDADEMTIDVDKTKA 163
Cdd:COG0112 83 FGAEHANVQPHSGSQANLAVYFALLKPGDTILGMDLAHGGHLTHGSP---VNFS-GKGYNVVSYGVDPETGLIDYDEVRK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 164 KVEELKaanrlPKMAMFGGSLFLFPHPVKELSDFLKGYNIHINYDAAHVAGLIAGGQFQDPLrEGADTMTMSTHKTLFGP 243
Cdd:COG0112 159 LALEHK-----PKLIIAGASAYPRPIDFARFREIADEVGAYLMVDMAHIAGLVAGGLHPSPV-PGADVVTTTTHKTLRGP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 244 QGGLVLGREEHAEPIKKATFPGLTSSHHIHHMAAKAIAFAEALEFG-KQYAKDVIKNAKALADALSDAGFKVLGekrGYT 322
Cdd:COG0112 233 RGGLILCNEELAKKIDSAVFPGLQGGPLMHVIAAKAVAFKEALTPEfKEYAKQVVKNAKALAEALAERGFRVVS---GGT 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 323 KSHQIAVNVLDYSDGGK-VEADLEKANIIVNRQLIPGDIkagRNYFHPGGIRLGVSELTRLGMKSAEMKEIAGYIKNIVI 401
Cdd:COG0112 310 DNHLVLVDLRSKGLTGKeAEKALERAGITVNKNAIPFDP---RSPFVTSGIRIGTPAVTTRGMKEAEMEEIAELIADVLD 386
|
410 420
....*....|....*....|...
gi 851341915 402 EKKDP---KKLAAKVKSFRKDYQ 421
Cdd:COG0112 387 NPEDEavlAEVREEVKELCKRFP 409
|
|
| glyA |
PRK00011 |
serine hydroxymethyltransferase; Reviewed |
17-426 |
1.63e-168 |
|
serine hydroxymethyltransferase; Reviewed
Pssm-ID: 234571 Cd Length: 416 Bit Score: 479.57 E-value: 1.63e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 17 LQEHNKWFENSIPLIASENVPSPAVKEALLSDFGNRYAEGWPGERVYAGCVYIDKVEIECMNLAKKLYKAKFADVRPISG 96
Cdd:PRK00011 17 IEQELKRQEEHIELIASENFVSPAVMEAQGSVLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKELFGAEYANVQPHSG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 97 VVANLAVYSAFTNPGDVMIAPSIPAGGHISHGKKehSGTAGLvhGLDIEFYPFDADEMTIDVDKTKAKVEELKaanrlPK 176
Cdd:PRK00011 97 SQANAAVYFALLKPGDTILGMDLAHGGHLTHGSP--VNFSGK--LYNVVSYGVDEETGLIDYDEVEKLALEHK-----PK 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 177 MAMFGGSLFLFPHPVKELSDFLKGYNIHINYDAAHVAGLIAGGQFQDPLReGADTMTMSTHKTLFGPQGGLVLGR-EEHA 255
Cdd:PRK00011 168 LIIAGASAYSRPIDFKRFREIADEVGAYLMVDMAHIAGLVAAGVHPSPVP-HADVVTTTTHKTLRGPRGGLILTNdEELA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 256 EPIKKATFPGLTSSHHIHHMAAKAIAFAEALEFG-KQYAKDVIKNAKALADALSDAGFKVLGekrGYTKSHQIAVNVLDY 334
Cdd:PRK00011 247 KKINSAVFPGIQGGPLMHVIAAKAVAFKEALEPEfKEYAQQVVKNAKALAEALAERGFRVVS---GGTDNHLVLVDLRSK 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 335 SDGGK-VEADLEKANIIVNRQLIPGDikaGRNYFHPGGIRLGVSELTRLGMKSAEMKEIAGYIKNIVI---EKKDPKKLA 410
Cdd:PRK00011 324 GLTGKeAEAALEEANITVNKNAVPFD---PRSPFVTSGIRIGTPAITTRGFKEAEMKEIAELIADVLDnpdDEAVIEEVK 400
|
410
....*....|....*.
gi 851341915 411 AKVKSFRKDYQKVHYC 426
Cdd:PRK00011 401 EEVKELCKRFPLYKYL 416
|
|
| SHMT |
cd00378 |
Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate ... |
11-416 |
3.53e-146 |
|
Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl group of N5, N10-methylene tetrahydrofolate to glycine resulting in the formation of serine and tetrahydrofolate. Both eukaryotic and prokaryotic SHMT enzymes form tight obligate homodimers; the mammalian enzyme forms a homotetramer comprising four pyridoxal phosphate-bound active sites.
Pssm-ID: 99733 Cd Length: 402 Bit Score: 422.00 E-value: 3.53e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 11 KKILSDLQEHNKWFENSIPLIASENVPSPAVKEALLSDFGNRYAEGWPGERVYAGCVYIDKVEIECMNLAKKLYKAKFAD 90
Cdd:cd00378 5 PEIAEIIKKENERQRETLELIASENFTSPAVMEAMGSDLTNKYAEGYPGKRYYGGCEYVDEIEDLAIERAKKLFGAEYAN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 91 VRPISGVVANLAVYSAFTNPGDVMIAPSIPAGGHISHGKKehsGTAGLVHGLDIEF-YPFDADEMTIDVDKTKAKVEELK 169
Cdd:cd00378 85 VQPHSGSQANLAVYFALLEPGDTIMGLDLSHGGHLTHGSF---TKVSASGKLFESVpYGVDPETGLIDYDALEKMALEFK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 170 aanrlPKMAMFGGSLFLFPHPVKELSDFLKGYNIHINYDAAHVAGLIAGGQFQDPLReGADTMTMSTHKTLFGPQGGLVL 249
Cdd:cd00378 162 -----PKLIVAGASAYPRPIDFKRFREIADEVGAYLLVDMAHVAGLVAGGVFPNPLP-GADVVTTTTHKTLRGPRGGLIL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 250 GR-EEHAEPIKKATFPGLTSSHHIHHMAAKAIAFAEALE-FGKQYAKDVIKNAKALADALSDAGFKVLGEKRGytkSHQI 327
Cdd:cd00378 236 TRkGELAKKINSAVFPGLQGGPHLHVIAAKAVALKEALEpEFKAYAKQVVENAKALAEALKERGFKVVSGGTD---NHLV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 328 AVNVLDYS-DGGKVEADLEKANIIVNRQLIPGDIKAGrnyFHPGGIRLGVSELTRLGMKSAEMKEIAGYIKNIVIEKKD- 405
Cdd:cd00378 313 LVDLRPKGiTGKAAEDALEEAGITVNKNTLPWDPSSP---FVPSGIRIGTPAMTTRGMGEEEMEEIADFIARALKDAEDv 389
|
410
....*....|...
gi 851341915 406 --PKKLAAKVKSF 416
Cdd:cd00378 390 avAEEVRKEVAEL 402
|
|
| SHMT |
pfam00464 |
Serine hydroxymethyltransferase; |
25-396 |
1.14e-83 |
|
Serine hydroxymethyltransferase;
Pssm-ID: 395372 Cd Length: 399 Bit Score: 262.38 E-value: 1.14e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 25 ENSIPLIASENVPSPAVKEALLSDFGNRYAEGWPGERVYAGCVYIDKVEIECMNLAKKLYKAK----FADVRPISGVVAN 100
Cdd:pfam00464 20 REGIELIASENFTSRAVMEALGSVLTNKYSEGYPGKRYYGGCEHVDEIETLCQDRALEAFGLDpakwGVNVQPLSGSPAN 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 101 LAVYSAFTNPGDVMIAPSIPAGGHISHGKKEHSGTAGLVhGLDIEFYPFDADEMT--IDVDKTKAKVEELKaanrlPKMA 178
Cdd:pfam00464 100 LAVYTALLEPGDRIMGLDLPHGGHLTHGYPVNSKKISAS-SKFFESMPYGVDPETgyIDYDQLEKNAKLFR-----PKLI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 179 MFGGS----LFLFPHpVKELSDFLKGYnihINYDAAHVAGLIAGGQFQDPLrEGADTMTMSTHKTLFGPQGGLVLGR--- 251
Cdd:pfam00464 174 VAGTSaysrLIDYAR-FREIADEVGAY---LMVDMAHISGLVAAGVIPSPF-PYADVVTTTTHKTLRGPRGGMIFYRkgv 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 252 -----------EEHAEPIKKATFPGLTSSHHIHHMAAKAIAFAEAL--EFgKQYAKDVIKNAKALADALSDAGFKVLGek 318
Cdd:pfam00464 249 ksvdktgkeilYELEKKINSAVFPGLQGGPHNHVIAAKAVALKQALtpEF-KEYQQQVVKNAKALAEALTERGYKLVS-- 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 851341915 319 rGYTKSHQIAVNVLDYS-DGGKVEADLEKANIIVNRQLIPGDIKAgrnyFHPGGIRLGVSELTRLGMKSAEMKEIAGYI 396
Cdd:pfam00464 326 -GGTDNHLVLVDLRPKGlDGARAEKVLEAANITANKNTIPGDKSA----FVPSGLRLGTPALTSRGFGEADFEKVAGFI 399
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| GlyA |
COG0112 |
Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Glycine/serine ... |
4-421 |
1.38e-180 |
|
Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Glycine/serine hydroxymethyltransferase is part of the Pathway/BioSystem: Serine biosynthesis
Pssm-ID: 439882 Cd Length: 414 Bit Score: 509.96 E-value: 1.38e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 4 SATKASYKKILSDLQEHNKWFENSIPLIASENVPSPAVKEALLSDFGNRYAEGWPGERVYAGCVYIDKVEIECMNLAKKL 83
Cdd:COG0112 3 SSLAEVDPEIAEAIEKELERQEEGIELIASENFVSPAVLEAQGSVLTNKYAEGYPGKRYYGGCEYVDEVEQLAIERAKEL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 84 YKAKFADVRPISGVVANLAVYSAFTNPGDVMIAPSIPAGGHISHGKKehsGTAGlVHGLDIEFYPFDADEMTIDVDKTKA 163
Cdd:COG0112 83 FGAEHANVQPHSGSQANLAVYFALLKPGDTILGMDLAHGGHLTHGSP---VNFS-GKGYNVVSYGVDPETGLIDYDEVRK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 164 KVEELKaanrlPKMAMFGGSLFLFPHPVKELSDFLKGYNIHINYDAAHVAGLIAGGQFQDPLrEGADTMTMSTHKTLFGP 243
Cdd:COG0112 159 LALEHK-----PKLIIAGASAYPRPIDFARFREIADEVGAYLMVDMAHIAGLVAGGLHPSPV-PGADVVTTTTHKTLRGP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 244 QGGLVLGREEHAEPIKKATFPGLTSSHHIHHMAAKAIAFAEALEFG-KQYAKDVIKNAKALADALSDAGFKVLGekrGYT 322
Cdd:COG0112 233 RGGLILCNEELAKKIDSAVFPGLQGGPLMHVIAAKAVAFKEALTPEfKEYAKQVVKNAKALAEALAERGFRVVS---GGT 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 323 KSHQIAVNVLDYSDGGK-VEADLEKANIIVNRQLIPGDIkagRNYFHPGGIRLGVSELTRLGMKSAEMKEIAGYIKNIVI 401
Cdd:COG0112 310 DNHLVLVDLRSKGLTGKeAEKALERAGITVNKNAIPFDP---RSPFVTSGIRIGTPAVTTRGMKEAEMEEIAELIADVLD 386
|
410 420
....*....|....*....|...
gi 851341915 402 EKKDP---KKLAAKVKSFRKDYQ 421
Cdd:COG0112 387 NPEDEavlAEVREEVKELCKRFP 409
|
|
| glyA |
PRK00011 |
serine hydroxymethyltransferase; Reviewed |
17-426 |
1.63e-168 |
|
serine hydroxymethyltransferase; Reviewed
Pssm-ID: 234571 Cd Length: 416 Bit Score: 479.57 E-value: 1.63e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 17 LQEHNKWFENSIPLIASENVPSPAVKEALLSDFGNRYAEGWPGERVYAGCVYIDKVEIECMNLAKKLYKAKFADVRPISG 96
Cdd:PRK00011 17 IEQELKRQEEHIELIASENFVSPAVMEAQGSVLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKELFGAEYANVQPHSG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 97 VVANLAVYSAFTNPGDVMIAPSIPAGGHISHGKKehSGTAGLvhGLDIEFYPFDADEMTIDVDKTKAKVEELKaanrlPK 176
Cdd:PRK00011 97 SQANAAVYFALLKPGDTILGMDLAHGGHLTHGSP--VNFSGK--LYNVVSYGVDEETGLIDYDEVEKLALEHK-----PK 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 177 MAMFGGSLFLFPHPVKELSDFLKGYNIHINYDAAHVAGLIAGGQFQDPLReGADTMTMSTHKTLFGPQGGLVLGR-EEHA 255
Cdd:PRK00011 168 LIIAGASAYSRPIDFKRFREIADEVGAYLMVDMAHIAGLVAAGVHPSPVP-HADVVTTTTHKTLRGPRGGLILTNdEELA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 256 EPIKKATFPGLTSSHHIHHMAAKAIAFAEALEFG-KQYAKDVIKNAKALADALSDAGFKVLGekrGYTKSHQIAVNVLDY 334
Cdd:PRK00011 247 KKINSAVFPGIQGGPLMHVIAAKAVAFKEALEPEfKEYAQQVVKNAKALAEALAERGFRVVS---GGTDNHLVLVDLRSK 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 335 SDGGK-VEADLEKANIIVNRQLIPGDikaGRNYFHPGGIRLGVSELTRLGMKSAEMKEIAGYIKNIVI---EKKDPKKLA 410
Cdd:PRK00011 324 GLTGKeAEAALEEANITVNKNAVPFD---PRSPFVTSGIRIGTPAITTRGFKEAEMKEIAELIADVLDnpdDEAVIEEVK 400
|
410
....*....|....*.
gi 851341915 411 AKVKSFRKDYQKVHYC 426
Cdd:PRK00011 401 EEVKELCKRFPLYKYL 416
|
|
| SHMT |
cd00378 |
Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate ... |
11-416 |
3.53e-146 |
|
Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl group of N5, N10-methylene tetrahydrofolate to glycine resulting in the formation of serine and tetrahydrofolate. Both eukaryotic and prokaryotic SHMT enzymes form tight obligate homodimers; the mammalian enzyme forms a homotetramer comprising four pyridoxal phosphate-bound active sites.
Pssm-ID: 99733 Cd Length: 402 Bit Score: 422.00 E-value: 3.53e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 11 KKILSDLQEHNKWFENSIPLIASENVPSPAVKEALLSDFGNRYAEGWPGERVYAGCVYIDKVEIECMNLAKKLYKAKFAD 90
Cdd:cd00378 5 PEIAEIIKKENERQRETLELIASENFTSPAVMEAMGSDLTNKYAEGYPGKRYYGGCEYVDEIEDLAIERAKKLFGAEYAN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 91 VRPISGVVANLAVYSAFTNPGDVMIAPSIPAGGHISHGKKehsGTAGLVHGLDIEF-YPFDADEMTIDVDKTKAKVEELK 169
Cdd:cd00378 85 VQPHSGSQANLAVYFALLEPGDTIMGLDLSHGGHLTHGSF---TKVSASGKLFESVpYGVDPETGLIDYDALEKMALEFK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 170 aanrlPKMAMFGGSLFLFPHPVKELSDFLKGYNIHINYDAAHVAGLIAGGQFQDPLReGADTMTMSTHKTLFGPQGGLVL 249
Cdd:cd00378 162 -----PKLIVAGASAYPRPIDFKRFREIADEVGAYLLVDMAHVAGLVAGGVFPNPLP-GADVVTTTTHKTLRGPRGGLIL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 250 GR-EEHAEPIKKATFPGLTSSHHIHHMAAKAIAFAEALE-FGKQYAKDVIKNAKALADALSDAGFKVLGEKRGytkSHQI 327
Cdd:cd00378 236 TRkGELAKKINSAVFPGLQGGPHLHVIAAKAVALKEALEpEFKAYAKQVVENAKALAEALKERGFKVVSGGTD---NHLV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 328 AVNVLDYS-DGGKVEADLEKANIIVNRQLIPGDIKAGrnyFHPGGIRLGVSELTRLGMKSAEMKEIAGYIKNIVIEKKD- 405
Cdd:cd00378 313 LVDLRPKGiTGKAAEDALEEAGITVNKNTLPWDPSSP---FVPSGIRIGTPAMTTRGMGEEEMEEIADFIARALKDAEDv 389
|
410
....*....|...
gi 851341915 406 --PKKLAAKVKSF 416
Cdd:cd00378 390 avAEEVRKEVAEL 402
|
|
| SHMT |
pfam00464 |
Serine hydroxymethyltransferase; |
25-396 |
1.14e-83 |
|
Serine hydroxymethyltransferase;
Pssm-ID: 395372 Cd Length: 399 Bit Score: 262.38 E-value: 1.14e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 25 ENSIPLIASENVPSPAVKEALLSDFGNRYAEGWPGERVYAGCVYIDKVEIECMNLAKKLYKAK----FADVRPISGVVAN 100
Cdd:pfam00464 20 REGIELIASENFTSRAVMEALGSVLTNKYSEGYPGKRYYGGCEHVDEIETLCQDRALEAFGLDpakwGVNVQPLSGSPAN 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 101 LAVYSAFTNPGDVMIAPSIPAGGHISHGKKEHSGTAGLVhGLDIEFYPFDADEMT--IDVDKTKAKVEELKaanrlPKMA 178
Cdd:pfam00464 100 LAVYTALLEPGDRIMGLDLPHGGHLTHGYPVNSKKISAS-SKFFESMPYGVDPETgyIDYDQLEKNAKLFR-----PKLI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 179 MFGGS----LFLFPHpVKELSDFLKGYnihINYDAAHVAGLIAGGQFQDPLrEGADTMTMSTHKTLFGPQGGLVLGR--- 251
Cdd:pfam00464 174 VAGTSaysrLIDYAR-FREIADEVGAY---LMVDMAHISGLVAAGVIPSPF-PYADVVTTTTHKTLRGPRGGMIFYRkgv 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 252 -----------EEHAEPIKKATFPGLTSSHHIHHMAAKAIAFAEAL--EFgKQYAKDVIKNAKALADALSDAGFKVLGek 318
Cdd:pfam00464 249 ksvdktgkeilYELEKKINSAVFPGLQGGPHNHVIAAKAVALKQALtpEF-KEYQQQVVKNAKALAEALTERGYKLVS-- 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 851341915 319 rGYTKSHQIAVNVLDYS-DGGKVEADLEKANIIVNRQLIPGDIKAgrnyFHPGGIRLGVSELTRLGMKSAEMKEIAGYI 396
Cdd:pfam00464 326 -GGTDNHLVLVDLRPKGlDGARAEKVLEAANITANKNTIPGDKSA----FVPSGLRLGTPALTSRGFGEADFEKVAGFI 399
|
|
| PRK13034 |
PRK13034 |
serine hydroxymethyltransferase; Reviewed |
25-416 |
1.67e-80 |
|
serine hydroxymethyltransferase; Reviewed
Pssm-ID: 237280 Cd Length: 416 Bit Score: 254.50 E-value: 1.67e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 25 ENSIPLIASENVPSPAVKEALLSDFGNRYAEGWPGERVYAGCVYIDKVEIECMNLAKKLYKAKFADVRPISGVVANLAVY 104
Cdd:PRK13034 28 QDHLELIASENFTSPAVMEAQGSVLTNKYAEGYPGKRYYGGCEFVDEVEALAIERAKQLFGCDYANVQPHSGSQANGAVY 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 105 SAFTNPGDVMIAPSIPAGGHISHGKKEhSGTAGLVHGLdieFYPFDADEMTIDVDktkaKVEELKAANRlPKMAMFGGSL 184
Cdd:PRK13034 108 LALLKPGDTILGMSLSHGGHLTHGAKV-SLSGKWYNAV---QYGVDRLTGLIDYD----EVEELAKEHK-PKLIIAGFSA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 185 FlfphpVKELsDFLKGYNI------HINYDAAHVAGLIAGGQFQDPLrEGADTMTMSTHKTLFGPQGGLVLGR-EEHAEP 257
Cdd:PRK13034 179 Y-----PREL-DFARFREIadevgaLLMVDMAHIAGLVAAGEHPNPF-PHAHVVTTTTHKTLRGPRGGMILTNdEEIAKK 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 258 IKKATFPGLTSSHHIHHMAAKAIAFAEALEFG-KQYAKDVIKNAKALADALSDAGFKVLGekrGYTKSHQIAVNVLDYSD 336
Cdd:PRK13034 252 INSAVFPGLQGGPLMHVIAAKAVAFGEALQPEfKTYAKQVIANAQALAEVLKERGYDLVS---GGTDNHLLLVDLRPKGL 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 337 GGK-VEADLEKANIIVNRQLIPGDIkagRNYFHPGGIRLGVSELTRLGMKSAEMKEIAGYI-------KNIVIEKKDPKK 408
Cdd:PRK13034 329 SGKdAEQALERAGITVNKNTVPGDT---ESPFVTSGIRIGTPAGTTRGFGEAEFREIANWIldvlddlGNAALEQRVRKE 405
|
....*...
gi 851341915 409 LAAKVKSF 416
Cdd:PRK13034 406 VKALCSRF 413
|
|
| PTZ00094 |
PTZ00094 |
serine hydroxymethyltransferase; Provisional |
26-418 |
3.67e-73 |
|
serine hydroxymethyltransferase; Provisional
Pssm-ID: 240264 Cd Length: 452 Bit Score: 236.80 E-value: 3.67e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 26 NSIPLIASENVPSPAVKEALLSDFGNRYAEGWPGERVYAGCVYIDKVEIECMNLAKKLYKAKF----ADVRPISGVVANL 101
Cdd:PTZ00094 35 EGLELIASENFTSRAVLECLGSCFTNKYAEGLPGNRYYGGNEVVDKIENLCQKRALEAFGLDPeewgVNVQPYSGSPANF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 102 AVYSAFTNPGDVMIAPSIPAGGHISHG----KKEHSGTAglvHGLDIEFYPFDADEMtIDVDktkaKVEELKAANRlPKM 177
Cdd:PTZ00094 115 AVYTALLQPHDRIMGLDLPSGGHLTHGfytaKKKVSATS---IYFESLPYQVNEKGL-IDYD----KLEELAKAFR-PKL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 178 AMFGGSLFlfphP-------VKELSDFLKGYnihINYDAAHVAGLIAGGQFQDPLrEGADTMTMSTHKTLFGPQGGLVL- 249
Cdd:PTZ00094 186 IIAGASAY----PrdidykrFREICDSVGAY---LMADIAHTSGLVAAGVLPSPF-PYADVVTTTTHKSLRGPRSGLIFy 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 250 ---GREEHAEPIKKATFPGLTSSHHIHHMAAKAIAFAEAL--EFgKQYAKDVIKNAKALADALSDAGFKVLGekrGYTKS 324
Cdd:PTZ00094 258 rkkVKPDIENKINEAVFPGLQGGPHNHQIAAIAVQLKEVQspEW-KEYAKQVLKNAKALAAALEKRGYDLVT---GGTDN 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 325 HQIAVNVLDYS-DGGKVEADLEKANIIVNRQLIPGDIKAgrnyFHPGGIRLGVSELTRLGMKSAEMKEIAGYIKNIV--- 400
Cdd:PTZ00094 334 HLVLVDLRPFGiTGSKMEKLLDAVNISVNKNTIPGDKSA----LNPSGVRLGTPALTTRGAKEKDFKFVADFLDRAVkla 409
|
410 420
....*....|....*....|
gi 851341915 401 --IEKKDPKKLAAKVKSFRK 418
Cdd:PTZ00094 410 qeIQKQVGKKLVDFKKALEK 429
|
|
| PLN03226 |
PLN03226 |
serine hydroxymethyltransferase; Provisional |
14-418 |
8.74e-63 |
|
serine hydroxymethyltransferase; Provisional
Pssm-ID: 215639 Cd Length: 475 Bit Score: 210.22 E-value: 8.74e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 14 LSDLQEHNK---WfeNSIPLIASENVPSPAVKEALLSDFGNRYAEGWPGERVYAGCVYIDKVEIECMNLAKKLYKAKFA- 89
Cdd:PLN03226 22 IADIIEKEKrrqW--KGLELIASENFTSRAVMEALGSCLTNKYSEGLPGARYYGGNEYIDQIETLCQKRALEAFRLDPEk 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 90 ---DVRPISGVVANLAVYSAFTNPGDVMIAPSIPAGGHISHG----KKEHSGTaglvhglDIEF--YPFDADEMT--IDV 158
Cdd:PLN03226 100 wgvNVQPLSGSPANFAVYTALLQPHDRIMGLDLPHGGHLSHGyqtdGKKISAT-------SIYFesMPYRLDESTglIDY 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 159 DktkaKVEElKAANRLPKMAMFGGSLF--LFPHP-VKELSDFLKGYnihINYDAAHVAGLIAGGQFQDPLrEGADTMTMS 235
Cdd:PLN03226 173 D----KLEK-KAMLFRPKLIIAGASAYprDWDYArMRKIADKVGAL---LMCDMAHISGLVAAQEAASPF-EYCDVVTTT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 236 THKTLFGPQGGLVLGREEHAEPIKK--------------ATFPGLTSSHHIHHMAAKAI--AFAEALEFgKQYAKDVIKN 299
Cdd:PLN03226 244 THKSLRGPRGGMIFFRKGPKPPKGQgegavydyedkinfAVFPGLQGGPHNHTIAALAValKQAMTPEF-KAYQKQVKAN 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 300 AKALADALSDAGFKVLGekrGYTKSHQIAVNVLDYS-DGGKVEADLEKANIIVNRQLIPGDIKAgrnyFHPGGIRLGVSE 378
Cdd:PLN03226 323 AAALANRLMSKGYKLVT---GGTDNHLVLWDLRPLGlTGSRVEKVLDLAHITLNKNAVPGDSSA----LVPGGVRIGTPA 395
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 851341915 379 LTRLGMKSAEMKEIAGYIKNIV-----IEKKDPKKLaakvKSFRK 418
Cdd:PLN03226 396 MTSRGLVEKDFEKVAEFLHRAVtialkIQKEHGKKL----KDFKK 436
|
|
| PRK13580 |
PRK13580 |
glycine hydroxymethyltransferase; |
27-399 |
3.22e-55 |
|
glycine hydroxymethyltransferase;
Pssm-ID: 184161 Cd Length: 493 Bit Score: 190.64 E-value: 3.22e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 27 SIPLIASENVPSPAVKEALLSDFGNRYAEGWPGERVYAGCVYIDKVEIECMNLAKKLYKAKFADVRPISGVVANLAVYSA 106
Cdd:PRK13580 51 SLKLIASENYSSLAVQLAMGNLLTDKYAEGTPGHRFYAGCQNVDTVEWEAAEHAKELFGAEHAYVQPHSGADANLVAFWA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 107 ---------------FTNPGD----------------VMIAPSIPAGGHISHGKKEHsgtaglVHGLDIEFYPFDADEMT 155
Cdd:PRK13580 131 ilahkvespaleklgAKTVNDlteedwealraelgnqRLLGMSLDSGGHLTHGFRPN------ISGKMFHQRSYGVDPDT 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 156 --IDVDKTKAKVEELKaanrlPKMAMFGGSlfLFPHPV-----KELSDFLkGYNIHInyDAAHVAGLIAGGQFQ---DPL 225
Cdd:PRK13580 205 glLDYDEIAALAREFK-----PLILVAGYS--AYPRRVnfaklREIADEV-GAVLMV--DMAHFAGLVAGKVFTgdeDPV 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 226 REgADTMTMSTHKTLFGPQGGLVLGREEHAEPIKKATfPGLTSSHHIHHMAAKAIAFAEAL--EFgKQYAKDVIKNAKAL 303
Cdd:PRK13580 275 PH-ADIVTTTTHKTLRGPRGGLVLAKKEYADAVDKGC-PLVLGGPLPHVMAAKAVALAEARtpEF-QKYAQQVVDNARAL 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 304 ADALSDAGFKVLgekRGYTKSHQIAVNVLDYSDGGKV-EADLEKANIIVNRQLIPGDiKAGRNYfhPGGIRLGVSELTRL 382
Cdd:PRK13580 352 AEGFLKRGARLV---TGGTDNHLVLIDVTSFGLTGRQaESALLDAGIVTNRNSIPSD-PNGAWY--TSGIRLGTPALTTL 425
|
410
....*....|....*..
gi 851341915 383 GMKSAEMKEIAGYIKNI 399
Cdd:PRK13580 426 GMGSDEMDEVAELIVKV 442
|
|
| PLN02271 |
PLN02271 |
serine hydroxymethyltransferase |
28-396 |
6.25e-37 |
|
serine hydroxymethyltransferase
Pssm-ID: 215153 Cd Length: 586 Bit Score: 142.25 E-value: 6.25e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 28 IPLIASENVPSPAVKEALLSDFGNRYAEGWPGERVYAGCVYIDKVEIECMNLAKK---LYKAKFA-DVRPISGVVANLAV 103
Cdd:PLN02271 151 IELIASENFVCRAVMEALGSHLTNKYSEGMPGARYYTGNQYIDQIERLCCERALAafgLDSEKWGvNVQPYSCTSANFAV 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 104 YSAFTNPGDVMIAPSIPAGGHISHGKKEHSGTAglVHGLDIEF--YPFDADEMT--IDVDktkaKVEElKAANRLPKMAM 179
Cdd:PLN02271 231 YTGLLLPGDRIMGLDSPSGGHMSHGYYTPGGKK--VSGASIFFesLPYKVNPQTgyIDYD----KLEE-KALDFRPKILI 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 180 FGGSlflfPHPvKELsDFLKGYNIH------INYDAAHVAGLIAGGQFQDPLrEGADTMTMSTHKTLFGPQGGLVLGRE- 252
Cdd:PLN02271 304 CGGS----SYP-REW-DYARFRQIAdkcgavLMCDMAHISGLVAAKECVNPF-DYCDIVTSTTHKSLRGPRGGIIFYRKg 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 253 -------------------EHAEPIKKATFPGLTSSHHIHHMAAKAIAFAEAL--EFgKQYAKDVIKNAKALADALSDAG 311
Cdd:PLN02271 377 pklrkqgmllshgddnshyDFEEKINFAVFPSLQGGPHNNHIAALAIALKQVAtpEY-KAYMQQVKKNAQALASALLRRK 455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 312 FKVLgekRGYTKSHQIAVNVLDYSDGGKV-EADLEKANIIVNRQLIPGDIKAgrnyFHPGGIRLGVSELTRLGMKSAEMK 390
Cdd:PLN02271 456 CRLV---TGGTDNHLLLWDLTTLGLTGKNyEKVCEMCHITLNKTAIFGDNGT----ISPGGVRIGTPAMTSRGCLESDFE 528
|
....*.
gi 851341915 391 EIAGYI 396
Cdd:PLN02271 529 TIADFL 534
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
75-251 |
8.82e-14 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 68.95 E-value: 8.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 75 ECMNLAKKLYKAKFADVRPI-SGVVANLAVYSAFTNPGDVMIapsIPAGGHISHgkkehSGTAGLVHGLDIEFYPFD-AD 152
Cdd:cd01494 4 ELEEKLARLLQPGNDKAVFVpSGTGANEAALLALLGPGDEVI---VDANGHGSR-----YWVAAELAGAKPVPVPVDdAG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 153 EMTIDVdktkAKVEELKAANRlPKMAMF--GGSLFLFPHPVKELSDFLKGYNIHINYDAAHvAGLIAGGQFQDPLREGAD 230
Cdd:cd01494 76 YGGLDV----AILEELKAKPN-VALIVItpNTTSGGVLVPLKEIRKIAKEYGILLLVDAAS-AGGASPAPGVLIPEGGAD 149
|
170 180
....*....|....*....|.
gi 851341915 231 TMTMSTHKTLFGPQGGLVLGR 251
Cdd:cd01494 150 VVTFSLHKNLGGEGGGVVIVK 170
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
37-396 |
5.34e-07 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 51.15 E-value: 5.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 37 PSPAVKEAL--LSDFGNRyaegwpgeRVYAGCVYIDKVEIEcmnLAKKLYKAKFADVRPISGVV-------ANLAVYSAF 107
Cdd:pfam00155 15 TLPAVAKAEkdALAGGTR--------NLYGPTDGHPELREA---LAKFLGRSPVLKLDREAAVVfgsgagaNIEALIFLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 108 TNPGDVMIapsIPAGGHISHGKkehsgtagLVHGLDIEFYPF---DADEMTIDVDKTKAKVEELkaanrlPKMaMFGGSL 184
Cdd:pfam00155 84 ANPGDAIL---VPAPTYASYIR--------IARLAGGEVVRYplyDSNDFHLDFDALEAALKEK------PKV-VLHTSP 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 185 F-----LFPHP-VKELSDFLKGYNIHINYDAAHVAGLIAGGQFQDP---LREGADTMTMSTHKTLFGPQG---GLVLGRE 252
Cdd:pfam00155 146 HnptgtVATLEeLEKLLDLAKEHNILLLVDEAYAGFVFGSPDAVATralLAEGPNLLVVGSFSKAFGLAGwrvGYILGNA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 253 EHAEPIKKATFPGLTSSHHIHHMAAKAIAFAEALEFGKQYAKDVIKNAKALADALSDAGFKVLGEKRGYtkshqIAVNVL 332
Cdd:pfam00155 226 AVISQLRKLARPFYSSTHLQAAAAAALSDPLLVASELEEMRQRIKERRDYLRDGLQAAGLSVLPSQAGF-----FLLTGL 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 851341915 333 D-YSDGGKVEADLEKANIIVnrqlIPGdikagrNYFH-PGGIRLGVSeltrlGMKSAEMKEIAGYI 396
Cdd:pfam00155 301 DpETAKELAQVLLEEVGVYV----TPG------SSPGvPGWLRITVA-----GGTEEELEELLEAI 351
|
|
| GadA |
COG0076 |
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ... |
152-317 |
2.27e-06 |
|
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis
Pssm-ID: 439846 [Multi-domain] Cd Length: 460 Bit Score: 49.83 E-value: 2.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 152 DEMTIDVDKTKAKVEELKAANRLPkMAMFG--GSlflFPH----PVKELSDFLKGYNIHINYDAAHVAGLIAGGQFQDPL 225
Cdd:COG0076 198 EDGRMDPDALEAAIDEDRAAGLNP-IAVVAtaGT---TNTgaidPLAEIADIAREHGLWLHVDAAYGGFALPSPELRHLL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 226 R--EGADTMTMSTHKTLFGPQG-GLVLGREEHAepikkatfpgLTSSHHIH------HMAAKAIAFAEALEFG------K 290
Cdd:COG0076 274 DgiERADSITVDPHKWLYVPYGcGAVLVRDPEL----------LREAFSFHasylgpADDGVPNLGDYTLELSrrfralK 343
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 851341915 291 QYA--------------KDVIKNAKALADALS-DAGFKVLGE 317
Cdd:COG0076 344 LWAtlralgregyreliERCIDLARYLAEGIAaLPGFELLAP 385
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
148-245 |
2.40e-05 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 46.04 E-value: 2.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 148 PFDADeMTIDVDKTKAKVEELKAANRLPkmAMFGGSLFLFPH----PVKELSDFLKGYNIHINYDAAHVAGLIAggqFQD 223
Cdd:cd06450 123 PVDED-GRMDPEALEAAIDEDKAEGLNP--IMVVATAGTTDTgaidPLEEIADLAEKYDLWLHVDAAYGGFLLP---FPE 196
|
90 100
....*....|....*....|....*..
gi 851341915 224 PLR-----EGADTMTMSTHKTLFGPQG 245
Cdd:cd06450 197 PRHldfgiERVDSISVDPHKYGLVPLG 223
|
|
| SelA |
pfam03841 |
L-seryl-tRNA selenium transferase; |
190-260 |
2.80e-04 |
|
L-seryl-tRNA selenium transferase;
Pssm-ID: 309101 Cd Length: 367 Bit Score: 42.71 E-value: 2.80e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 851341915 190 PVKELSDFLKGYNIHINYDAAHVA-------GLIAGGQFQDPLREGADTMTMSTHKTLFGPQGGLVLGREEHAEPIKK 260
Cdd:pfam03841 158 ELAELVELGHEKGLPVYEDLGSGSlvdlsqyGLPKEPTVQELIAQGVDLVSFSGDKLLGGPQAGIIVGKKELIERIKK 235
|
|
| SelA |
COG1921 |
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis]; |
190-260 |
1.32e-03 |
|
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441524 Cd Length: 399 Bit Score: 40.87 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 190 PVKELSDFLKGYNIHINYDAAhvAG-LIAGGQF--------QDPLREGADTMTMSTHKTLFGPQGGLVLGREEHAEPIKK 260
Cdd:COG1921 176 SLAELAELAHEHGLPVIVDLG--SGsLVDLSKYglpheptvQEYLAAGADLVTFSGDKLLGGPQAGIIVGKKELIERIKK 253
|
|
| Beta_elim_lyase |
pfam01212 |
Beta-eliminating lyase; |
95-325 |
2.16e-03 |
|
Beta-eliminating lyase;
Pssm-ID: 426128 [Multi-domain] Cd Length: 288 Bit Score: 39.89 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 95 SGVVANLAVYSAFTNPGDVMIApsipagGHISHGkkEHSGTAGLVHGLDIEFYPFDADEM-TIDVDKTKAKVEELKAANR 173
Cdd:pfam01212 55 SGTAANQLALMAHCQRGDEVIC------GEPAHI--HFDETGGHAELGGVQPRPLDGDEAgNMDLEDLEAAIREVGADIF 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 174 lPKMAM---------FGGSlflfPHP---VKELSDFLKGYNIHINYDAAHVA-GLIAGGqfqDPLRE---GADTMTMSTH 237
Cdd:pfam01212 127 -PPTGLislenthnsAGGQ----VVSlenLREIAALAREHGIPVHLDGARFAnAAVALG---VIVKEitsYADSVTMCLS 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 851341915 238 KTLFGPQGGLVLGREE-----------HAEPIKKATFP---GLTSshhihhmaakaiafaeaLEFGKQYAKDVIKNAKAL 303
Cdd:pfam01212 199 KGLGAPVGSVLAGSDDfiakairqrkyLGGGLRQAGVLaaaGLRA-----------------LEEGVARLARDHATARRL 261
|
250 260
....*....|....*....|..
gi 851341915 304 ADALSDAGFKVlgEKRGYTKSH 325
Cdd:pfam01212 262 AEGLELLRLAI--PRRVYTNTH 281
|
|
| |
