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Conserved domains on  [gi|937117282|ref|WP_054554661|]
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MULTISPECIES: iron donor protein CyaY [Pseudoalteromonas]

Protein Classification

iron donor protein CyaY( domain architecture ID 10022429)

iron donor protein CyaY is involved in iron-sulfur (Fe-S) cluster assembly and may act as a regulator of Fe-S biogenesis

CATH:  3.30.920.10
Gene Ontology:  GO:0008199|GO:0008198|GO:0016226
SCOP:  4001566
TCDB:  9.B.21

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FeS_CyaY TIGR03421
iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) ...
 2-103 3.66e-51

iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


:

Pssm-ID: 274572  Cd Length: 102  Bit Score: 156.22  E-value: 3.66e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937117282    2 TDHEYHTLADALMLTIEEQIDECDADLDYESASGILEIIFPDRSKIVINKQAPLHQVWVATKFNGHHFELRDDKWIDNRS 81
Cdd:TIGR03421   1 NESEFHQLAEALLDAIEEAIDDGDADIDCERQGGVLTLTFENGSQIIINKQEPLHQIWLAAKSGGFHFDYDGGAWIDTRD 80

                          90       100
                  ....*....|....*....|..
gi 937117282   82 GAEFWQFMCDAATRQAGQTIEW 103
Cdd:TIGR03421  81 GEELWALLARACSEQAGEPVVF 102
 
Name Accession Description Interval E-value
FeS_CyaY TIGR03421
iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) ...
 2-103 3.66e-51

iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274572  Cd Length: 102  Bit Score: 156.22  E-value: 3.66e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937117282    2 TDHEYHTLADALMLTIEEQIDECDADLDYESASGILEIIFPDRSKIVINKQAPLHQVWVATKFNGHHFELRDDKWIDNRS 81
Cdd:TIGR03421   1 NESEFHQLAEALLDAIEEAIDDGDADIDCERQGGVLTLTFENGSQIIINKQEPLHQIWLAAKSGGFHFDYDGGAWIDTRD 80

                          90       100
                  ....*....|....*....|..
gi 937117282   82 GAEFWQFMCDAATRQAGQTIEW 103
Cdd:TIGR03421  81 GEELWALLARACSEQAGEPVVF 102
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 1-105 1.07e-49

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 152.64  E-value: 1.07e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937117282   1 MTDHEYHTLADALMLTIEEQID-ECDADLDYESASGILEIIFPDRSKIVINKQAPLHQVWVATKFNGHHFELRDDKWIDN 79
Cdd:COG1965    1 MTESEFHQLADALLEAIEEALDrDDDADIDCERSGGVLTLEFDNGSKIIINRQEPLRQIWLAAKSGGFHFDYDDGKWIDT 80

                         90       100
                 ....*....|....*....|....*.
gi 937117282  80 RSGAEFWQFMCDAATRQAGQTIEWRS 105
Cdd:COG1965   81 RSGEELFALLSRALSEQAGEPVTLAA 106
cyaY PRK00446
frataxin-like protein; Provisional
 1-104 7.11e-43

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 135.39  E-value: 7.11e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937117282   1 MTDHEYHTLADALMLTIEEQIDEC-DADLDYESASGILEIIFPDRSKIVINKQAPLHQVWVATKFNGHHFELRDDKWIDN 79
Cdd:PRK00446   1 MNDSEFHQLADALWQAIEEQLDDDgDADIDCERNGGVLTLTFENGSKIIINRQEPLHELWLAAKSGGFHFDYKDGEWICD 80

                         90       100
                 ....*....|....*....|....*
gi 937117282  80 RSGAEFWQFMCDAATRQAGQTIEWR 104
Cdd:PRK00446  81 RSGEEFWALLEEAATQQAGEPVSFR 105
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 1-103 2.65e-37

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 121.60  E-value: 2.65e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937117282   1 MTDHEYHTLADALMLTIEEQIDECD--ADLDYESASGILEIIFPDRSKIVINKQAPLHQVWVATKFNGHHFELRDDKWID 78
Cdd:cd00503    1 MNESEFHRLADDLLLKIEDTLEEQDddADIDVETQGGVLTLTFGNGSTIVINRQEPLRQIWLASKVGGYHFDYKNGKWIC 80

                         90       100
                 ....*....|....*....|....*
gi 937117282  79 NRSGAEFWQFMCDAATRQAGQTIEW 103
Cdd:cd00503   81 TRSGEELWELLEEECSAQSGEDVEF 105
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 1-101 6.76e-36

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 118.01  E-value: 6.76e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937117282    1 MTDHEYHTLADALMLTIEEQIDE-----CDADLDYESasGILEIIFPDRSKIVINKQAPLHQVWVATKFNG-HHFELRD- 73
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEElldegSDADVEYSG--GVLTLEFDNGGTYVINKQPPNRQIWLSSPISGpFHFDYDDa 78

                          90       100
                  ....*....|....*....|....*...
gi 937117282   74 DKWIDNRSGAEFWQFMCDAATRQAGQTI 101
Cdd:pfam01491  79 GQWIYTRDGEELFELLSRELSEQLGEPV 106
 
Name Accession Description Interval E-value
FeS_CyaY TIGR03421
iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) ...
 2-103 3.66e-51

iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274572  Cd Length: 102  Bit Score: 156.22  E-value: 3.66e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937117282    2 TDHEYHTLADALMLTIEEQIDECDADLDYESASGILEIIFPDRSKIVINKQAPLHQVWVATKFNGHHFELRDDKWIDNRS 81
Cdd:TIGR03421   1 NESEFHQLAEALLDAIEEAIDDGDADIDCERQGGVLTLTFENGSQIIINKQEPLHQIWLAAKSGGFHFDYDGGAWIDTRD 80

                          90       100
                  ....*....|....*....|..
gi 937117282   82 GAEFWQFMCDAATRQAGQTIEW 103
Cdd:TIGR03421  81 GEELWALLARACSEQAGEPVVF 102
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 1-105 1.07e-49

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 152.64  E-value: 1.07e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937117282   1 MTDHEYHTLADALMLTIEEQID-ECDADLDYESASGILEIIFPDRSKIVINKQAPLHQVWVATKFNGHHFELRDDKWIDN 79
Cdd:COG1965    1 MTESEFHQLADALLEAIEEALDrDDDADIDCERSGGVLTLEFDNGSKIIINRQEPLRQIWLAAKSGGFHFDYDDGKWIDT 80

                         90       100
                 ....*....|....*....|....*.
gi 937117282  80 RSGAEFWQFMCDAATRQAGQTIEWRS 105
Cdd:COG1965   81 RSGEELFALLSRALSEQAGEPVTLAA 106
cyaY PRK00446
frataxin-like protein; Provisional
 1-104 7.11e-43

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 135.39  E-value: 7.11e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937117282   1 MTDHEYHTLADALMLTIEEQIDEC-DADLDYESASGILEIIFPDRSKIVINKQAPLHQVWVATKFNGHHFELRDDKWIDN 79
Cdd:PRK00446   1 MNDSEFHQLADALWQAIEEQLDDDgDADIDCERNGGVLTLTFENGSKIIINRQEPLHELWLAAKSGGFHFDYKDGEWICD 80

                         90       100
                 ....*....|....*....|....*
gi 937117282  80 RSGAEFWQFMCDAATRQAGQTIEWR 104
Cdd:PRK00446  81 RSGEEFWALLEEAATQQAGEPVSFR 105
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 1-103 2.65e-37

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 121.60  E-value: 2.65e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937117282   1 MTDHEYHTLADALMLTIEEQIDECD--ADLDYESASGILEIIFPDRSKIVINKQAPLHQVWVATKFNGHHFELRDDKWID 78
Cdd:cd00503    1 MNESEFHRLADDLLLKIEDTLEEQDddADIDVETQGGVLTLTFGNGSTIVINRQEPLRQIWLASKVGGYHFDYKNGKWIC 80

                         90       100
                 ....*....|....*....|....*
gi 937117282  79 NRSGAEFWQFMCDAATRQAGQTIEW 103
Cdd:cd00503   81 TRSGEELWELLEEECSAQSGEDVEF 105
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 1-101 6.76e-36

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 118.01  E-value: 6.76e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937117282    1 MTDHEYHTLADALMLTIEEQIDE-----CDADLDYESasGILEIIFPDRSKIVINKQAPLHQVWVATKFNG-HHFELRD- 73
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEElldegSDADVEYSG--GVLTLEFDNGGTYVINKQPPNRQIWLSSPISGpFHFDYDDa 78

                          90       100
                  ....*....|....*....|....*...
gi 937117282   74 DKWIDNRSGAEFWQFMCDAATRQAGQTI 101
Cdd:pfam01491  79 GQWIYTRDGEELFELLSRELSEQLGEPV 106
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 5-83 2.30e-13

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


Pssm-ID: 132463  Cd Length: 97  Bit Score: 60.33  E-value: 2.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937117282    5 EYHTLADALMLTIEEQIDE-------CDADLDYesASGILEIIFPDRSKIVINKQAPLHQVWVATKFNG-HHFELRDDKW 76
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEElgesrpdLDFDVEY--SSGVLTLELPSVGTYVINKQPPNKQIWLSSPVSGpKRYDYVNGEW 78


                  ....*..
gi 937117282   77 IDNRSGA 83
Cdd:TIGR03422  79 IYLRDGS 85
cyaY PRK01379
iron donor protein CyaY;
1-91 1.12e-05

iron donor protein CyaY;


Pssm-ID: 134546  Cd Length: 103  Bit Score: 40.69  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937117282   1 MTDHEYHTLADALMLTIEEQIDECD--ADLDYESASGILEIIfPDRSKIVINKQAPLHQVWVATKFNG-HHFELRDDKWi 77
Cdd:PRK01379   1 MNNSEFSKIAETTIAYIADKIEEQDkeASIDVDLQGDILNLD-TDKGIYVINKQSAAKEIWLSSPVSGpYHFFYEQGKW- 78

                         90
                 ....*....|....
gi 937117282  78 DNRSGAEFWQFMCD 91
Cdd:PRK01379  79 KNRAGLELMAILTE 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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