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Conserved domains on  [gi|1184576488|ref|WP_085141871|]
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carbohydrate-binding domain-containing protein [Mycolicibacterium conceptionense]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CBM60 super family cl25150
Ca-dependent carbohydrate-binding module xylan-binding; CBM60 is a family of xylan-binding ...
88-158 5.06e-05

Ca-dependent carbohydrate-binding module xylan-binding; CBM60 is a family of xylan-binding modules found in conjunction with xylanase enzymes in many bacterial species that attack plant cell walls. Xylan is the major hemicellulose component of most plant cell walls, and is one of the most complex carbohydrates targeted by CBMs. CBM60 modules are evolutionarily related to CBM36 domains as both show circular permutation in the beta-barrel folds. CBM60 targets xylan but is also able to bind cellulose and galactan and thus contribute towards breakdown of the plant cell wall. Recognition of the ligand is conferred primarily through the polar interactions of O2 (oxygen) and O3 of a single sugar with a protein-bound calcium ion.


The actual alignment was detected with superfamily member pfam16841:

Pssm-ID: 465281  Cd Length: 93  Bit Score: 42.27  E-value: 5.06e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1184576488  88 RAKGQRCQGM-PTMVVGIDGTTVGTTTVNATTWTDYATTVNIPAGSHAVTVAYTNDA-RSLLCDRNLLVDKLT 158
Cdd:pfam16841   5 RAAGDAAGGVpPHFRLLVDGKVVGTATVASTSWKDYTFTADLDADAHKVQIQYDNDAyVNDGQDRNLYVDSVT 77
 
Name Accession Description Interval E-value
CBM60 pfam16841
Ca-dependent carbohydrate-binding module xylan-binding; CBM60 is a family of xylan-binding ...
88-158 5.06e-05

Ca-dependent carbohydrate-binding module xylan-binding; CBM60 is a family of xylan-binding modules found in conjunction with xylanase enzymes in many bacterial species that attack plant cell walls. Xylan is the major hemicellulose component of most plant cell walls, and is one of the most complex carbohydrates targeted by CBMs. CBM60 modules are evolutionarily related to CBM36 domains as both show circular permutation in the beta-barrel folds. CBM60 targets xylan but is also able to bind cellulose and galactan and thus contribute towards breakdown of the plant cell wall. Recognition of the ligand is conferred primarily through the polar interactions of O2 (oxygen) and O3 of a single sugar with a protein-bound calcium ion.


Pssm-ID: 465281  Cd Length: 93  Bit Score: 42.27  E-value: 5.06e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1184576488  88 RAKGQRCQGM-PTMVVGIDGTTVGTTTVNATTWTDYATTVNIPAGSHAVTVAYTNDA-RSLLCDRNLLVDKLT 158
Cdd:pfam16841   5 RAAGDAAGGVpPHFRLLVDGKVVGTATVASTSWKDYTFTADLDADAHKVQIQYDNDAyVNDGQDRNLYVDSVT 77
 
Name Accession Description Interval E-value
CBM60 pfam16841
Ca-dependent carbohydrate-binding module xylan-binding; CBM60 is a family of xylan-binding ...
88-158 5.06e-05

Ca-dependent carbohydrate-binding module xylan-binding; CBM60 is a family of xylan-binding modules found in conjunction with xylanase enzymes in many bacterial species that attack plant cell walls. Xylan is the major hemicellulose component of most plant cell walls, and is one of the most complex carbohydrates targeted by CBMs. CBM60 modules are evolutionarily related to CBM36 domains as both show circular permutation in the beta-barrel folds. CBM60 targets xylan but is also able to bind cellulose and galactan and thus contribute towards breakdown of the plant cell wall. Recognition of the ligand is conferred primarily through the polar interactions of O2 (oxygen) and O3 of a single sugar with a protein-bound calcium ion.


Pssm-ID: 465281  Cd Length: 93  Bit Score: 42.27  E-value: 5.06e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1184576488  88 RAKGQRCQGM-PTMVVGIDGTTVGTTTVNATTWTDYATTVNIPAGSHAVTVAYTNDA-RSLLCDRNLLVDKLT 158
Cdd:pfam16841   5 RAAGDAAGGVpPHFRLLVDGKVVGTATVASTSWKDYTFTADLDADAHKVQIQYDNDAyVNDGQDRNLYVDSVT 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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