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Conserved domains on  [gi|1242621644|ref|WP_095764131|]
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MULTISPECIES: RHS repeat-associated core domain-containing protein, partial [Enterobacteriaceae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RHS_core super family cl49306
RHS element core protein;
1-119 3.15e-77

RHS element core protein;


The actual alignment was detected with superfamily member NF041261:

Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 254.16  E-value: 3.15e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242621644    1 DRLESEILADRVSEESRRWLASCGL-----------------------------PLALISTEGATAWCAEYDEWGNLLNE 51
Cdd:NF041261  1114 DRLEEEIRADRVSEESRAWLAQCGLtveqmarqvepeytparklhlyhcdhrglPLALISEEGNTAWQGEYDEWGNLLNE 1193

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1242621644   52 ENPHQLQQLIRLPGQQYDEESGLYYNRHRYYDPLQGRYITQDPIGLKGGWNFYQYPLNPISNIDPLGL 119
Cdd:NF041261  1194 ENPHHLQQPYRLPGQQYDEESGLYYNRNRYYDPLQGRYITQDPIGLKGGWNLYQYPLNPIRFIDPLGL 1261
 
Name Accession Description Interval E-value
RHS_core NF041261
RHS element core protein;
1-119 3.15e-77

RHS element core protein;


Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 254.16  E-value: 3.15e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242621644    1 DRLESEILADRVSEESRRWLASCGL-----------------------------PLALISTEGATAWCAEYDEWGNLLNE 51
Cdd:NF041261  1114 DRLEEEIRADRVSEESRAWLAQCGLtveqmarqvepeytparklhlyhcdhrglPLALISEEGNTAWQGEYDEWGNLLNE 1193

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1242621644   52 ENPHQLQQLIRLPGQQYDEESGLYYNRHRYYDPLQGRYITQDPIGLKGGWNFYQYPLNPISNIDPLGL 119
Cdd:NF041261  1194 ENPHHLQQPYRLPGQQYDEESGLYYNRNRYYDPLQGRYITQDPIGLKGGWNLYQYPLNPIRFIDPLGL 1261
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
 24-193 6.52e-37

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 138.74  E-value: 6.52e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242621644   24 GLPLALISTEGATAWCAEYDEWGNLLNEENPHQLQQLiRLPGQQYDEESGLYYNRHRYYDPLQGRYITQDPIGLKGGWNF 103
Cdd:COG3209    930 GSVRALTDASGQVVWRYDYDPFGNLLAETSGAAANPL-RFTGQEYDAETGLYYNGARYYDPALGRFLSPDPIGLAGGLNL 1008

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242621644  104 YQYPL-NPISNIDPLGLETL--KCIKPLHSMGGTGERSGPDIWGNPFYHQYLCVPDGKGDYTCGGQDQRGESKGDGLWGP 180
Cdd:COG3209   1009 YAYVGnNPVNYVDPLGLAALlgTTGLGGGAGVGAGAAGGGAAAAGGSAGAGAAGGGAGGAGAGGAGGGAGAGAGAAAGAA 1088

                          170
                   ....*....|...
gi 1242621644  181 GKASNDTKEAAGR 193
Cdd:COG3209   1089 GGAGGGAGASGAG 1101
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
 42-119 9.49e-34

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 117.22  E-value: 9.49e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1242621644  42 YDEWGNLLNEENPhqLQQLIRLPGQQYDEESGLYYNRHRYYDPLQGRYITQDPIGLKGGWNFYQY-PLNPISNIDPLGL 119
Cdd:TIGR03696   1 YDPYGEVLSESGA--APNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPDPIGLGGGLNLYAYvGNNPVNWVDPLGL 77
RHS pfam03527
RHS protein;
24-52 1.63e-06

RHS protein;


Pssm-ID: 427349 [Multi-domain]  Cd Length: 38  Bit Score: 43.83  E-value: 1.63e-06
                          10        20
                  ....*....|....*....|....*....
gi 1242621644  24 GLPLALISTEGATAWCAEYDEWGNLLNEE 52
Cdd:pfam03527  10 GTPEELTDEAGEIVWSAEYDAWGNVTEER 38
OCRE cd16074
OCRE domain; The OCRE (OCtamer REpeat) domain contains 5 repeats of an 8-residue motif, which ...
 65-94 7.78e-03

OCRE domain; The OCRE (OCtamer REpeat) domain contains 5 repeats of an 8-residue motif, which were shown to form beta-strands. Based on the architectures of proteins containing OCRE domains, a role in RNA metabolism and/or signalling has been proposed.


Pssm-ID: 293880  Cd Length: 54  Bit Score: 33.80  E-value: 7.78e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1242621644  65 GQQYDEESGLYYNRHR--YYDPLQGRYITQDP 94
Cdd:cd16074    15 GYYYDPSTGLYYDPNTgyYYDPTSGTYYIWDD 46
 
Name Accession Description Interval E-value
RHS_core NF041261
RHS element core protein;
1-119 3.15e-77

RHS element core protein;


Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 254.16  E-value: 3.15e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242621644    1 DRLESEILADRVSEESRRWLASCGL-----------------------------PLALISTEGATAWCAEYDEWGNLLNE 51
Cdd:NF041261  1114 DRLEEEIRADRVSEESRAWLAQCGLtveqmarqvepeytparklhlyhcdhrglPLALISEEGNTAWQGEYDEWGNLLNE 1193

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1242621644   52 ENPHQLQQLIRLPGQQYDEESGLYYNRHRYYDPLQGRYITQDPIGLKGGWNFYQYPLNPISNIDPLGL 119
Cdd:NF041261  1194 ENPHHLQQPYRLPGQQYDEESGLYYNRNRYYDPLQGRYITQDPIGLKGGWNLYQYPLNPIRFIDPLGL 1261
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
 24-193 6.52e-37

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 138.74  E-value: 6.52e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242621644   24 GLPLALISTEGATAWCAEYDEWGNLLNEENPHQLQQLiRLPGQQYDEESGLYYNRHRYYDPLQGRYITQDPIGLKGGWNF 103
Cdd:COG3209    930 GSVRALTDASGQVVWRYDYDPFGNLLAETSGAAANPL-RFTGQEYDAETGLYYNGARYYDPALGRFLSPDPIGLAGGLNL 1008

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242621644  104 YQYPL-NPISNIDPLGLETL--KCIKPLHSMGGTGERSGPDIWGNPFYHQYLCVPDGKGDYTCGGQDQRGESKGDGLWGP 180
Cdd:COG3209   1009 YAYVGnNPVNYVDPLGLAALlgTTGLGGGAGVGAGAAGGGAAAAGGSAGAGAAGGGAGGAGAGGAGGGAGAGAGAAAGAA 1088

                          170
                   ....*....|...
gi 1242621644  181 GKASNDTKEAAGR 193
Cdd:COG3209   1089 GGAGGGAGASGAG 1101
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
 42-119 9.49e-34

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 117.22  E-value: 9.49e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1242621644  42 YDEWGNLLNEENPhqLQQLIRLPGQQYDEESGLYYNRHRYYDPLQGRYITQDPIGLKGGWNFYQY-PLNPISNIDPLGL 119
Cdd:TIGR03696   1 YDPYGEVLSESGA--APNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPDPIGLGGGLNLYAYvGNNPVNWVDPLGL 77
RHS pfam03527
RHS protein;
24-52 1.63e-06

RHS protein;


Pssm-ID: 427349 [Multi-domain]  Cd Length: 38  Bit Score: 43.83  E-value: 1.63e-06
                          10        20
                  ....*....|....*....|....*....
gi 1242621644  24 GLPLALISTEGATAWCAEYDEWGNLLNEE 52
Cdd:pfam03527  10 GTPEELTDEAGEIVWSAEYDAWGNVTEER 38
OCRE cd16074
OCRE domain; The OCRE (OCtamer REpeat) domain contains 5 repeats of an 8-residue motif, which ...
 65-94 7.78e-03

OCRE domain; The OCRE (OCtamer REpeat) domain contains 5 repeats of an 8-residue motif, which were shown to form beta-strands. Based on the architectures of proteins containing OCRE domains, a role in RNA metabolism and/or signalling has been proposed.


Pssm-ID: 293880  Cd Length: 54  Bit Score: 33.80  E-value: 7.78e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1242621644  65 GQQYDEESGLYYNRHR--YYDPLQGRYITQDP 94
Cdd:cd16074    15 GYYYDPSTGLYYDPNTgyYYDPTSGTYYIWDD 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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